CN105029514A - Modifier capable of reducing saxitox - Google Patents
Modifier capable of reducing saxitox Download PDFInfo
- Publication number
- CN105029514A CN105029514A CN201510331825.6A CN201510331825A CN105029514A CN 105029514 A CN105029514 A CN 105029514A CN 201510331825 A CN201510331825 A CN 201510331825A CN 105029514 A CN105029514 A CN 105029514A
- Authority
- CN
- China
- Prior art keywords
- parts
- saxitoxin
- modifier
- reducing
- astaxanthin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003607 modifier Substances 0.000 title abstract 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 24
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims abstract description 22
- RPQXVSUAYFXFJA-HGRQIUPRSA-N saxitoxin Chemical compound NC(=O)OC[C@@H]1N=C(N)N2CCC(O)(O)[C@@]22N=C(N)N[C@@H]12 RPQXVSUAYFXFJA-HGRQIUPRSA-N 0.000 claims abstract description 17
- RPQXVSUAYFXFJA-UHFFFAOYSA-N saxitoxin hydrate Natural products NC(=O)OCC1N=C(N)N2CCC(O)(O)C22NC(N)=NC12 RPQXVSUAYFXFJA-UHFFFAOYSA-N 0.000 claims abstract description 17
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 claims abstract description 13
- 235000013793 astaxanthin Nutrition 0.000 claims abstract description 13
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims abstract description 13
- 229940022405 astaxanthin Drugs 0.000 claims abstract description 13
- 239000001168 astaxanthin Substances 0.000 claims abstract description 13
- 229920000858 Cyclodextrin Polymers 0.000 claims abstract description 11
- 239000001116 FEMA 4028 Substances 0.000 claims abstract description 11
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims abstract description 11
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims abstract description 11
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims abstract description 11
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims abstract description 11
- 229960004853 betadex Drugs 0.000 claims abstract description 11
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims abstract description 11
- 235000005875 quercetin Nutrition 0.000 claims abstract description 11
- 229960001285 quercetin Drugs 0.000 claims abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000003795 chemical substances by application Substances 0.000 claims description 19
- JDLKFOPOAOFWQN-VIFPVBQESA-N Allicin Natural products C=CCS[S@](=O)CC=C JDLKFOPOAOFWQN-VIFPVBQESA-N 0.000 claims description 11
- JDLKFOPOAOFWQN-UHFFFAOYSA-N allicin Chemical compound C=CCSS(=O)CC=C JDLKFOPOAOFWQN-UHFFFAOYSA-N 0.000 claims description 11
- 235000010081 allicin Nutrition 0.000 claims description 11
- 235000013305 food Nutrition 0.000 abstract description 8
- 239000000796 flavoring agent Substances 0.000 abstract description 2
- 235000019634 flavors Nutrition 0.000 abstract description 2
- 241000195493 Cryptophyta Species 0.000 description 10
- 239000003053 toxin Substances 0.000 description 5
- 231100000765 toxin Toxicity 0.000 description 5
- 231100000614 poison Toxicity 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 241000199914 Dinophyceae Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 230000007096 poisonous effect Effects 0.000 description 3
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 2
- 241000200031 Alexandrium Species 0.000 description 2
- 241000206572 Rhodophyta Species 0.000 description 2
- 239000004383 Steviol glycoside Substances 0.000 description 2
- 235000019688 fish Nutrition 0.000 description 2
- 239000013505 freshwater Substances 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 210000003127 knee Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229930182488 steviol glycoside Natural products 0.000 description 2
- 235000019411 steviol glycoside Nutrition 0.000 description 2
- 150000008144 steviol glycosides Chemical class 0.000 description 2
- 235000019202 steviosides Nutrition 0.000 description 2
- 241000200030 Alexandrium catenella Species 0.000 description 1
- 241001531229 Alexandrium minutum Species 0.000 description 1
- 241000282836 Camelus dromedarius Species 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000237536 Mytilus edulis Species 0.000 description 1
- 241000237509 Patinopecten sp. Species 0.000 description 1
- 241001238245 Saxidomus Species 0.000 description 1
- 241000269821 Scombridae Species 0.000 description 1
- 108010052164 Sodium Channels Proteins 0.000 description 1
- 102000018674 Sodium Channels Human genes 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 239000003181 biological factor Substances 0.000 description 1
- 238000010170 biological method Methods 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 229940075397 calomel Drugs 0.000 description 1
- 230000007541 cellular toxicity Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- ZOMNIUBKTOKEHS-UHFFFAOYSA-L dimercury dichloride Chemical compound Cl[Hg][Hg]Cl ZOMNIUBKTOKEHS-UHFFFAOYSA-L 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 235000020640 mackerel Nutrition 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 235000020638 mussel Nutrition 0.000 description 1
- PPEKGEBBBBNZKS-HGRQIUPRSA-N neosaxitoxin Chemical compound N=C1N(O)[C@@H](COC(=O)N)[C@@H]2NC(=N)N[C@@]22C(O)(O)CCN21 PPEKGEBBBBNZKS-HGRQIUPRSA-N 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 244000062645 predators Species 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000020637 scallop Nutrition 0.000 description 1
- 239000013535 sea water Substances 0.000 description 1
- 235000015170 shellfish Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention provides a modifier capable of reducing saxitoxin. The modifier capable of reducing saxitoxin is characterized by comprising the following components in parts by weight: 10-100 parts of garlicin, 10-200 parts of astaxanthin, 10-200 parts of beta-cyclodextrin, 10-200 parts of quercetin, 500-1000 parts of ethanol and 500-1000 parts of water. The modifier is capable of filling up the blank in the industry; the modifier which utilizes garlicin and astaxanthin as main components is capable of reducing the saxitoxin in food by no less than 50%, and does not cause substitutability influence on original flavor of the food; furthermore, the modifier adopts natural components and conforms to the food safety requirement.
Description
Technical field
The present invention relates to a kind of modifying agent reducing saxitoxin.
Background technology
Saxitoxin, (Saxitoxin, STX) is a kind of derivative of tetrahydrochysene purine, is the solid white, hygroscopicity is very strong, water-soluble, is slightly soluble in methyl alcohol and ethanol.STX and natural derivative have very high fatal rate, and it suppresses neural conduction by affecting sodium-ion channel.STX is 110 μ g to adult's calomel poisoning amount, and lethal dose is 540-1000 μ g, STX and neoSTX toxicity is the highest, and LD50 is 9 μ g/kg(mouse, ip).In view of the high harmfulness of STX and the popularity of distribution, countries in the world are all classified as the essential items for inspection of Safety of Aquatic Products inspection.
Detection method mainly comprises bioassay method and instrument detection method etc., and to the detection of STX, biological method reliability is strong, uses extensively; Chemical apparatuses method is accurate, highly sensitive, but the acquisition of standard items is more difficult; Although and other such as cell toxicity test and receptor analysis methods etc. are accurate, selectivity is high, self still awaits further Improvement and perfection.
STX derives from some poisonous marine algae at first, mainly dinoflagellate belongs to some algae of (dinoflagellattattegenus), comprises chain knee ditch algae (Gonyaulaxcatenella), tower camel former knee ditch algae (Protogonyaulaxtamarensis), Alexandrium (Alexandriumcatenella), Alexandrium mimutum Halim (Alexandriumminutum) etc.Some fresh water algae also can produce STX, as Fresh Watcr Blue Algae (Cylindrospermopsisraciborrskii), also produces this toxoid, but not yet finally confirm in some bacterium and red algae.The highest species of fixed product poison are dinoflagellates, are the pathogenic microorganisms of red tide.In addition, on fresh water and seawater river Puffer fish, amphibian animal (spot toad), red algae and the bacterium of separating from dinoflagellate cell.The toxin that these algae produce, accumulates in the aquatic products such as Filter feeding bivalves, fish, shrimp, crab, as mussel, Saxidomus, scallop, mackerel, decorative pattern love clean crab etc. by food chain.The toxin kind that different poisonous algae produces is different with content, and the toxin kind that the poisonous algae of same produces is also different at biological Different growth phases with content, toxin produces situation and is also subject to biological factor (as bacterium) and abiotic factor (as illumination, temperature, nutritive salt etc.) impact simultaneously.And toxin can transmit to more higher leveled predator.By biological concentration aquatic food web, pass to land living beings group, finally arrive the mankind.
A kind of modifying agent reducing saxitoxin content of current shortage exists.
Summary of the invention
The present invention has filled up blank in the industry, utilize the modifying agent that allicin and astaxanthin are key component, saxitoxin more than 50% in food can be reduced, substituting impact can't be caused on food original flavor, modifying agent is natural constituents simultaneously, meets food safety requirements.
Technical scheme of the present invention is:
Reduce a modifying agent for saxitoxin, it is characterized in that it comprises following parts by weight of component:
Allicin 10-100
Astaxanthin 10-200
Beta cyclodextrin 10-200
Quercetin 10-200
Ethanol 500-1000
Water 500-1000.
Inventor finds, shellfish meat gruel after modifying agent immersion treatment or algae dry powder, can reduce saxitoxin more than 50%, and its action principle is not fully aware of at present, may be that certain cross-linking reaction occurs for component in modifying agent and saxitoxin, produce certain complex compound and cause.
Detailed description of the invention
Embodiment 1
Reduce a modifying agent for saxitoxin, comprise following parts by weight of component:
Allicin 10
Astaxanthin 10
Beta cyclodextrin 10
Quercetin 10
Ethanol 500
Water 500.
Embodiment 2
As different from Example 1, this programme modifying agent comprises following parts by weight of component:
Allicin 100
Astaxanthin 200
Beta cyclodextrin 200
Quercetin 200
Ethanol 1000
Water 1000.
Embodiment 3
As different from Example 1, this programme modifying agent comprises following parts by weight of component:
Allicin 30
Astaxanthin 30
Beta cyclodextrin 60
Quercetin 50
Ethanol 1000
Water 1000.
Embodiment 4
As different from Example 1, this programme modifying agent comprises following parts by weight of component:
Allicin 70
Astaxanthin 40
Beta cyclodextrin 200
Quercetin 60
Ethanol 800
Water 800.
Embodiment 5
As different from Example 1, this programme modifying agent comprises following parts by weight of component:
Allicin 50
Astaxanthin 50
Beta cyclodextrin 100
Quercetin 30
Ethanol 1000
Water 1000.
Embodiment 6
As different from Example 1, this programme modifying agent comprises following parts by weight of component:
Allicin 60
Astaxanthin 40
Beta cyclodextrin 200
Quercetin 50
Ethanol 1000
Water 1000.
Embodiment 7
As different from Example 1, this programme modifying agent comprises following parts by weight of component:
Allicin 70
Astaxanthin 30
Beta cyclodextrin 200
Quercetin 50
Ethanol 1000
Water 1000.
Embodiment 8
As different from Example 1, this programme modifying agent comprises following parts by weight of component:
Allicin 70
Astaxanthin 30
Beta cyclodextrin 200
Quercetin 50
Ethanol 1000
Water 1000
Steviol glycoside 20.
Inventor finds, adding of steviol glycoside a small amount of in this programme, improves the performance about 5% of modifying agent.Do not find that other embodiment schemes have identical synergistic effect temporarily.
Inventor analyzes rear discovery by HPLC method to saxitoxin standard items and embodiment sample, and modifying agent of the present invention can reduce saxitoxin more than 50%, and wherein embodiment 8 reduces saxitoxin the best, reaches 70%.
Claims (1)
1. reduce a modifying agent for saxitoxin, it is characterized in that it comprises following parts by weight of component:
Allicin 10-100
Astaxanthin 10-200
Beta cyclodextrin 10-200
Quercetin 10-200
Ethanol 500-1000
Water 500-1000.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510331825.6A CN105029514A (en) | 2015-06-16 | 2015-06-16 | Modifier capable of reducing saxitox |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510331825.6A CN105029514A (en) | 2015-06-16 | 2015-06-16 | Modifier capable of reducing saxitox |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105029514A true CN105029514A (en) | 2015-11-11 |
Family
ID=54436959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510331825.6A Pending CN105029514A (en) | 2015-06-16 | 2015-06-16 | Modifier capable of reducing saxitox |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105029514A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109187795A (en) * | 2018-09-28 | 2019-01-11 | 威海长青海洋科技股份有限公司 | A kind of soak reducing okadaic acid content of toxins |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001029250A1 (en) * | 1999-10-15 | 2001-04-26 | Universidade De Santiago De Compostela | Quantification of paralyzing toxins (psp) by fluorimetry in excitable cells |
| US20020035032A1 (en) * | 1998-09-15 | 2002-03-21 | Olga Koper | Reactive nanoparticles as destructive adsorbents for biological and chemical contamination |
| CN102206270A (en) * | 2011-01-27 | 2011-10-05 | 中国水产科学研究院黄海水产研究所 | Saxitoxin artificial antigen, anti-saxitoxin antibody prepared by the saxitoxin artificial antigen, and their preparation methods and application |
| CN103300262A (en) * | 2013-05-06 | 2013-09-18 | 中国海洋大学 | Method for degrading and converting aflatoxin by utilizing astaxanthin |
-
2015
- 2015-06-16 CN CN201510331825.6A patent/CN105029514A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020035032A1 (en) * | 1998-09-15 | 2002-03-21 | Olga Koper | Reactive nanoparticles as destructive adsorbents for biological and chemical contamination |
| WO2001029250A1 (en) * | 1999-10-15 | 2001-04-26 | Universidade De Santiago De Compostela | Quantification of paralyzing toxins (psp) by fluorimetry in excitable cells |
| CN102206270A (en) * | 2011-01-27 | 2011-10-05 | 中国水产科学研究院黄海水产研究所 | Saxitoxin artificial antigen, anti-saxitoxin antibody prepared by the saxitoxin artificial antigen, and their preparation methods and application |
| CN103300262A (en) * | 2013-05-06 | 2013-09-18 | 中国海洋大学 | Method for degrading and converting aflatoxin by utilizing astaxanthin |
Non-Patent Citations (2)
| Title |
|---|
| 史贤明: "《食品安全与卫生学》", 31 March 2003, 中国农业出版社 * |
| 孙丹等: "石房蛤毒素的研究进展", 《安徽农业科学》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109187795A (en) * | 2018-09-28 | 2019-01-11 | 威海长青海洋科技股份有限公司 | A kind of soak reducing okadaic acid content of toxins |
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|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20151111 |