CN104971438A - Tissue equivalent compensator manufacturing method and tissue equivalent compensator - Google Patents
Tissue equivalent compensator manufacturing method and tissue equivalent compensator Download PDFInfo
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- CN104971438A CN104971438A CN201510443537.XA CN201510443537A CN104971438A CN 104971438 A CN104971438 A CN 104971438A CN 201510443537 A CN201510443537 A CN 201510443537A CN 104971438 A CN104971438 A CN 104971438A
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Abstract
The invention relates to the technical field of a medical apparatus, and discloses a tissue equivalent compensator manufacturing method. The tissue equivalent compensator manufacturing method comprises the following steps: (1) according the wounded part of a patient and a ray irradiation range, modeling the dimension of the shape of the tissue equivalent compensator; and (2) performing 3D printing according to the model, and obtaining the tissue equivalent compensator. The tissue equivalent compensator manufacturing method has advantages of ultra-short manufacturing period, ultra-high yield rate and relatively low cost. The tissue equivalent compensator which is manufactured according to the tissue equivalent compensator manufacturing method improves the dosage amount for the skin and furthermore has advantages of high uniformity, no easy deformation and high fixability. Furthermore the tissue equivalent compensator improves treatment accuracy.
Description
Technical field
The present invention relates to medical instruments field, particularly equivalence organizes the manufacture method of indemnity and equivalence to organize indemnity.
Background technology
Radiotherapy, or the Comprehensive Treatment based on radiotherapy is for preferred therapeutic scheme the most general in oncotherapy in current medical domain.Wherein, the tumor of head and neck of more than 70% all needs radiocurable intervention.
But, because emitting radiation exists dosage buildup effect, when some patients tumor invading skin or distance skin nearer time, will cause skin dose deficiency, thoroughly cannot kill cancerous cell.Such as, when incidence carcinogenesis skin is invaded, and when running into the breast carcinoma needing thoracic wall to irradiate, the problem of skin dose deficiency will have a strong impact on therapeutic effect.
Now, usually the additional one piece of equivalence of skin surface in affected part can organize indemnity, increase skin dose, thus reach our clinical required dose requirements.
Traditional equivalence organizes indemnity usually to adopt face shield labelling or body surface marking, is fixed up and inconvenience.Further, traditional equivalence organizes indemnity usually to select vaseline, paraffin to make.Lack of homogeneity, the skin-friendly of these materials are poor, yielding, fixing difficulty, are difficult to meet treatment requirement.
In addition, because the complex-shaped of indemnity is organized in equivalence, degree is customized very high.Therefore be usually difficult to the moulding technology method manufacture adopting thermoplastic, thermosetting, cast etc. conventional, its manufacturing cycle is long, and yield rate is low, and die sinking is with high costs.
Summary of the invention
A kind of equivalence is the object of the present invention is to provide to organize the manufacture method of indemnity, this manufacture method has the extremely short manufacturing cycle, high yield rate and lower cost, the equivalence utilizing this equivalence to organize the manufacture method of indemnity to produce organizes indemnity not only to contribute to improving skin dose, and uniformity good, not yielding, can fix, contribute to improving the accuracy of radiotherapy.
For solving the problems of the technologies described above, embodiments of the present invention provide the manufacture method that indemnity is organized in a kind of equivalence, comprise the steps:
(1) according to affected part and the roentgenization scope of patient, the geomery of indemnity is organized to carry out modeling to equivalence;
(2) utilize the model built carry out 3D printing, obtain equivalence and organize indemnity.
Embodiments of the present invention additionally provide a kind of equivalence utilizing said method to obtain and organize indemnity.
In terms of existing technologies, embodiments of the present invention are by utilizing microcomputer modelling, and the mode of 3D printout, can construct the product of correspondingly-shaped for the affected part of different patient, therefore achieve the customization of height.Usually, after microcomputer modelling, 3D prints this process of finished product and only needs 1 to 2 hour, and because printing device takes up room little, can directly realize within the hospital printing, also reduce the time because of circulation cost further, therefore, for traditional die sinking moulding technology, embodiments of the present invention highly shortened production life cycle, prevent the delay of the state of an illness.In addition, indemnity is organized in the equivalence that 3D printing device can print countless different model, and indemnity is organized in the equivalence that traditional die sinking moulding technology mould can only produce a shape.Therefore, embodiments of the present invention also considerably reduce production cost for traditional handicraft, decrease the waste of resource.
As preferably, the material that 3D prints can be multiple material.Due to the outstanding advantage of macromolecular material in cost, plasticity, biocompatibility etc., therefore become the preferred material that indemnity is organized in equivalence.Get on very well further, as preferably, this macromolecular material is polylactic acid.The equivalence of selecting polylactic acid to make organizes indemnity except having the advantage of macromolecular material on cost, plasticity and biocompatibility, its material safety is nontoxic, glossiness, the transparency, feel and thermostability are all very outstanding, more crucially, the even density of indemnity is organized in the equivalence of selecting polylactic acid to make, and can be competent at the task that indemnity is organized in equivalence better.Further, the equivalence that polylactic acid is made organizes indemnity to be biodegradable, very environmental protection.
As preferably, following step can also be comprised after step (2):
(3) the outer surface pre-coated thermoplastic film of indemnity is organized in equivalence.
Utilize the thermoplastic film of plastic type to fix indemnity and patients head simultaneously, and equivalence also can be helped better to organize indemnity to be fixed after thermoplastic film sizing, prevent it from moving.
As preferably, in embodiments of the present invention, equivalence organizes indemnity to have inner surface, and inner surface is for pasting the skin of patient.For equivalence organizes indemnity to distinguish surfaces externally and internally in advance, can carry out pre-designed for two surperficial differences.Inner surface prints comparatively smooth, improves the comfort level of patient.
As preferably, the shape of inner surface matches with the surface configuration of illing skin.Get on very well further, as preferably, when equivalence organizes indemnity for parotid gland region, a lateral edges of inner surface forms ear curved surface and angle of mandible curved surface; Wherein, ear curved surface coincide with the shape of the ear base of patient, and angle of mandible curved surface coincide with the shape of the angle of mandible of patient; Ear curved surface is postponed to the edge of angle of mandible curved surface.
Due to ear and angle of mandible shape comparatively complicated, the traditional equivalence being applied to parotid gland region organizes indemnity to be easy to come off.The equivalence of embodiments of the present invention organizes indemnity when in use, indemnity equivalence is organized to be affixed on the corresponding position of patient skin along the curved surface designed, the laminating effect fitted together perfectly can be possessed, thus significantly reduce the probability come off, and then significantly improve the dose accuracy of radiotherapy.
Or equivalence organizes indemnity also to may be used for cheek area, a side end of inner surface forms nose curved surface, and opposite side forms buccal curved surface; Nose curved surface coincide with the profile of the nose of patient, and buccal curved surface coincide with the shape of patient's cheek to malar; Buccal curved surface is postponed to equivalence and is organized the middle part of indemnity, is connected with nose curved surface.
Because cheek position is usually comparatively smooth, the traditional equivalence being applied to cheek area organizes indemnity also for easily to come off.And embodiments of the present invention utilize nose curved surface to play hook effect, equivalence is prevented to organize coming off of indemnity further.
In addition, as preferably, equivalence organizes the side of indemnity also can be bent to form the occlusal crib coordinated with dental articulation incisura, and opposite side then can form lower jaw curved surface, and lower jaw curved surface matches with the shape of the lower jaw of patient.By lower jaw curved surface with the shape of the lower jaw of patient match can significantly improve that this equivalence organizes indemnity paste performance, and improve the comfortableness of patient.
Or equivalence is organized the side of indemnity can give prominence to formation teeth mark and is stung mould, and opposite side then forms buccal curved surface, and buccal curved surface coincide with the cheek shape of patient.For in buccal, upper jaw gingiva or the treatment of lower jaw gingival neoplasms, good fiting effect will be had, and organize for indemnity more firm relative to the equivalence of aclusion.
When being applied to the radiotherapy of oral cancer patient, organizing indemnity to have due to this equivalence needs to be placed in patient oral cavity at least partially, therefore should not carry out the division of surfaces externally and internally with imposing uniformity without examining individual cases.As preferably, be engaged incisura according to patient teeth and carry out coordinating fixing equivalence to organize indemnity, its fixing-stable, not easily movement come off, to treat accuracy higher.
Accompanying drawing explanation
The front schematic view of Fig. 1 to be second embodiment of the invention for the equivalence of parotid gland region organize indemnity;
The application schematic diagram of Fig. 2 to be second embodiment of the invention for the equivalence of parotid gland region organize indemnity;
The front schematic view of Fig. 3 to be second embodiment of the invention for the equivalence of cheek area organize indemnity;
The application schematic diagram of Fig. 4 to be second embodiment of the invention for the equivalence of cheek area organize indemnity;
Fig. 5 is the front schematic view that third embodiment of the invention forms that indemnity is organized in the equivalence of occlusal crib;
Fig. 6 is the side schematic view that third embodiment of the invention forms that indemnity is organized in the equivalence of occlusal crib;
Fig. 7 is the application schematic diagram that third embodiment of the invention forms that indemnity is organized in the equivalence of occlusal crib.
Fig. 8 is the front schematic view that second embodiment of the invention forms that indemnity is organized in equivalence that teeth mark stings mould;
Fig. 9 is the application schematic diagram that second embodiment of the invention forms that indemnity is organized in equivalence that teeth mark stings mould.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearly, below in conjunction with accompanying drawing, the embodiments of the present invention are explained in detail.But, persons of ordinary skill in the art may appreciate that in each embodiment of the present invention, proposing many ins and outs to make reader understand the application better.But, even without these ins and outs with based on the many variations of following embodiment and amendment, each claim of the application technical scheme required for protection also can be realized.
First embodiment of the present invention relates to the manufacture method that indemnity is organized in a kind of equivalence, comprises the steps:
(1) according to affected part and the roentgenization scope of patient, the geomery of indemnity is organized to carry out modeling to equivalence;
(2) utilize the model built carry out 3D printing, obtain equivalence and organize indemnity.
In terms of existing technologies, present embodiment is by utilizing microcomputer modelling, and the mode of 3D printout, can construct the product of correspondingly-shaped for the affected part of different patient, therefore achieves the customization of height.Usually, after microcomputer modelling, 3D prints this process of finished product and only needs 1 to 2 hour, and because printing device takes up room little, can directly realize within the hospital printing, also reduce the time because of circulation cost further, therefore, for traditional die sinking moulding technology, present embodiment highly shortened production life cycle, prevents the delay of the state of an illness.In addition, indemnity is organized in the equivalence that 3D printing device can print countless different model, and indemnity is organized in the equivalence that traditional die sinking moulding technology mould can only produce a shape.Therefore, present embodiment also considerably reduces production cost for traditional handicraft, decreases the waste of resource.
In the present embodiment, the material that 3D prints can be multiple material.Due to the outstanding advantage of macromolecular material in cost, plasticity, biocompatibility etc., therefore become the preferred material that indemnity is organized in equivalence.Get on very well further, in the present embodiment, this macromolecular material is polylactic acid.The equivalence of selecting polylactic acid to make organizes indemnity except having the advantage of macromolecular material on cost, plasticity and biocompatibility, its material safety is nontoxic, glossiness, the transparency, feel and thermostability are all very outstanding, more crucially, the even density of indemnity is organized in the equivalence of selecting polylactic acid to make, CT value and human body soft tissue are very close, can be competent at the task that indemnity is organized in equivalence better.Further, the equivalence that polylactic acid is made organizes indemnity to be biodegradable, very environmental protection.
In the present embodiment, following step can also be comprised after step (2):
(3) the outer surface pre-coated thermoplastic film of indemnity is organized in equivalence.
During use, first can open thermoplastic film, then equivalence be organized indemnity to utilize thermoplastic film to be jointly coated on human body surface.Utilize the thermoplastic film of plastic type to fix indemnity and patients head simultaneously, and equivalence also can be helped better to organize indemnity to be fixed after thermoplastic film sizing, prevent it from moving.
Second embodiment of the present invention relates to a kind of equivalence and organizes indemnity, and this equivalence organizes indemnity to organize the manufacture method manufacture of indemnity to obtain by the equivalence in the first embodiment.In the second embodiment of the present invention, equivalence organizes indemnity to have inner surface, and inner surface is for pasting the skin of patient.
For equivalence organizes indemnity to distinguish surfaces externally and internally in advance, can carry out pre-designed for two surperficial differences.Such as, can be smooth for pasting the inner surface of patient skin, to provide better comfortableness.Outer surface then may be used for pasting thermoplastic film, can be provided with many row's micro-groove groove structures by array, thus make thermoplastic film to organize indemnity to bond with this equivalence better for thermoplastic film.Therefore, furthermore, in the present embodiment, this equivalence is organized indemnity can also comprise outer surface and is covered on the thermoplastic film of outer surface.
In the present embodiment, the shape of inner surface matches with the surface configuration of illing skin.Get on very well further, such as, shown in Figure 1, when equivalence organizes indemnity for parotid gland region, a lateral edges of inner surface forms ear curved surface 1 and angle of mandible curved surface 2; Wherein, ear curved surface 1 coincide with the shape of the ear base of patient, and angle of mandible curved surface 2 coincide with the shape of the angle of mandible of patient; Ear curved surface 1 is postponed to the edge of angle of mandible curved surface 2.
Due to ear and angle of mandible shape comparatively complicated, the traditional equivalence being applied to parotid gland region organizes indemnity to be easy to come off.Shown in Figure 2, the equivalence of present embodiment organizes indemnity when in use, indemnity equivalence is organized to be affixed on the corresponding position of patient skin along the curved surface designed, the laminating effect fitted together perfectly can be possessed, thus significantly reduce the probability come off, and then significantly improve the dose accuracy of radiotherapy.
Again such as, shown in Figure 3, equivalence organizes indemnity also to may be used for cheek area, and a side end of inner surface forms nose curved surface 5, and opposite side forms buccal curved surface 6; Nose curved surface 5 coincide with the profile of the nose of patient, and buccal curved surface 6 coincide with the shape of patient's cheek to malar; Buccal curved surface 6 is postponed to equivalence and is organized the middle part of indemnity, is connected with nose curved surface 5.
Because cheek position is usually comparatively smooth, the traditional equivalence being applied to cheek area organizes indemnity also for easily to come off.Shown in Figure 4, and embodiments of the present invention are when in use, utilize nose curved surface 5 to play hook effect, coordinate the laminating effect of buccal difference, prevent equivalence to organize coming off of indemnity further.
Obviously, in the present embodiment, equivalence organizes indemnity can also make according to the shape of other affected parts, thus adapts to different diseases.
3rd embodiment of the present invention relates to a kind of equivalence and organizes indemnity, and this equivalence organizes indemnity to organize the manufacture method manufacture of indemnity to obtain by the equivalence in the first embodiment.3rd embodiment of the present invention is slightly different from the second embodiment, main difference part is: in the second embodiment of the present invention, equivalence organizes indemnity to have can by the surfaces externally and internally distinguished, and there is a surface to be exclusively used in and paste patient skin, and in the 3rd embodiment of the present invention: shown in Figure 5, equivalence organizes the curving of indemnity to form the occlusal crib 3 coordinated with dental articulation incisura.Shown in Figure 6, equivalence organizes the opposite side of indemnity to form lower jaw curved surface 4, and lower jaw curved surface 4 matches with the shape of the lower jaw of patient.By lower jaw curved surface 4 with the shape of the lower jaw of patient match can significantly improve that this equivalence organizes indemnity paste performance, and improve the comfortableness of patient.Furthermore, in the present embodiment, lower jaw curved surface 4 can also encase lower jaw completely, thus plays a protective role to healthy position to a certain extent.
Shown in Figure 7, the equivalence of present embodiment organizes indemnity when in use, equivalence is organized the occlusal crib 3 of indemnity to insert patient oral cavity internal gearing, utilizes the coated patient's lower jaw of lower jaw curved surface 4, the laminating effect fitted together perfectly can be possessed, thus significantly improve Radiotherapy dosimetry degree of accuracy.
Certainly, in the present embodiment, shown in Figure 8, equivalence organizes the outstanding teeth mark that formed in the side of indemnity to sting mould 8, and opposite side then forms buccal curved surface 6, and buccal curved surface 6 coincide with the cheek shape of patient.Shown in Figure 9, during use, teeth mark is stung mould and is engaged containing in entrance by patient, and buccal curved surface 6 is fitted in cheek position.Thus, in buccal, upper jaw gingiva or the treatment of lower jaw gingival neoplasms, good fiting effect will be had, and organize for indemnity more firm relative to the equivalence of aclusion.
When being applied to the radiotherapy of oral cancer patient, organizing indemnity to have due to this equivalence needs to be placed in patient oral cavity at least partially, therefore should not carry out the division of surfaces externally and internally with imposing uniformity without examining individual cases.In the present embodiment, be engaged incisura according to patient teeth and carry out coordinating fixing equivalence to organize indemnity, its fixing-stable, not easily movement come off, to treat accuracy higher.
In the present embodiment, equivalence organizes indemnity to be coated with thermoplastic film in vain outward, and this thermoplastic film is coated on equivalence and organizes indemnity and patient facial region, forms face shield.Utilize thermoplastic film can play fixation further.
Persons of ordinary skill in the art may appreciate that the respective embodiments described above realize specific embodiments of the invention, and in actual applications, various change can be done to it in the form and details, and without departing from the spirit and scope of the present invention.
Claims (10)
1. a manufacture method for indemnity is organized in equivalence, it is characterized in that: comprise the steps:
(1) according to affected part and the roentgenization scope of patient, the geomery of indemnity is organized to carry out modeling to equivalence;
(2) utilize the model built carry out 3D printing, obtain equivalence and organize indemnity.
2. the manufacture method of indemnity is organized in equivalence according to claim 1, it is characterized in that: after described step (2), also comprise following step:
(3) the outer surface pre-coated thermoplastic film of indemnity is organized in described equivalence.
3. the manufacture method of indemnity is organized in equivalence according to claim 1, it is characterized in that: the material that described 3D prints is macromolecular material.
4. the manufacture method of indemnity is organized in equivalence according to claim 3, it is characterized in that: described macromolecular material is polylactic acid.
5. an indemnity is organized in equivalence, it is characterized in that: described equivalence organizes indemnity to organize the manufacture method manufacture of indemnity to obtain by the equivalence in Claims 1-4 described in any one.
6. indemnity is organized in equivalence according to claim 5, it is characterized in that: described equivalence organizes indemnity to have inner surface, and described inner surface is for pasting the skin of patient.
7. indemnity is organized in equivalence according to claim 6, it is characterized in that: the shape of described inner surface matches with the surface configuration of illing skin.
8. indemnity is organized in equivalence according to claim 7, it is characterized in that: described equivalence organizes indemnity for parotid gland region, and a lateral edges of described inner surface forms ear curved surface and angle of mandible curved surface; Described ear curved surface coincide with the shape of the ear base of patient, and described angle of mandible curved surface coincide with the shape of the angle of mandible of patient; Described ear curved surface is postponed to the edge of described angle of mandible curved surface;
Or described equivalence organizes indemnity for cheek area, a side end of described inner surface forms nose curved surface, and opposite side forms buccal curved surface; Described nose curved surface coincide with the profile of the nose of patient, and described buccal curved surface coincide with the shape of patient's cheek to malar; Described buccal curved surface is postponed to described equivalence and is organized the middle part of indemnity, is connected with described nose curved surface.
9. indemnity is organized in equivalence according to claim 5, it is characterized in that: described equivalence organizes the curving of indemnity to form the occlusal crib coordinated with dental articulation incisura, opposite side forms lower jaw curved surface, and described lower jaw curved surface matches with the shape of the lower jaw of patient.
10. indemnity is organized in equivalence according to claim 9, it is characterized in that: described equivalence organizes the outstanding teeth mark that formed in the side of indemnity to sting mould; Opposite side forms buccal curved surface, and described buccal curved surface coincide with the cheek shape of patient.
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| CN201510443537.XA CN104971438A (en) | 2015-07-24 | 2015-07-24 | Tissue equivalent compensator manufacturing method and tissue equivalent compensator |
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| CN105498099A (en) * | 2015-11-30 | 2016-04-20 | 北京大学第一医院 | Preparation method and system of tissue compensator |
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| USD1029255S1 (en) | 2020-09-01 | 2024-05-28 | Cilag Gmbh International | Stapling cartridge assembly with a compressible adjunct |
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Application publication date: 20151014 |