CN104921735A - Microwave noninvasive blood glucose measurement system - Google Patents
Microwave noninvasive blood glucose measurement system Download PDFInfo
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- CN104921735A CN104921735A CN201510248064.8A CN201510248064A CN104921735A CN 104921735 A CN104921735 A CN 104921735A CN 201510248064 A CN201510248064 A CN 201510248064A CN 104921735 A CN104921735 A CN 104921735A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
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Abstract
The invention relates to a microwave noninvasive blood glucose measurement system, comprising a microwave transceiving unit, a microwave detection unit, a signal processing unit, and an output unit. The microwave transceiving unit comprises a microwave generation module and a microwave receiving module. The microwave generation module generates a microwave signal to blood to be measured, through the microwave detection unit. The microwave detection unit receives the microwave signal and transmits it to the microwave receiving module for receiving; the microwave generation module generates the microwave 1 GHz to 100 GHz. The signal processing unit acquires a dielectric feature value according to the microwave signal received by the microwave receiving module and converts the dielectric feature value into a blood glucose measured value. The output unit outputs the blood glucose measured value.
Description
Technical field
The present invention relates to a kind of blood sugar measuring system, particularly relate to a kind of invasive blood sugar measuring system based on microwave.
Background technology
The method of traditional detection blood glucose is that puncture extraction blood is undertaken by biochemical analysis in body, this have the blood sugar test technology of wound to can be used for hospital clinical diagnosis and family health care health care, but due to needs blood drawing, there is the risk that measuring frequency is limited, easily cause discomfort, even infect in this technology, make troubles to diabetics, therefore, the research carrying out novel noninvasive dynamics monitoring technology very tool is of great significance.Current Noninvasive Blood Glucose Detection Methods mainly contains polarimetry, optoacoustic method, Raman spectroscopy, light scattering coefficient method, infrared spectrometry etc.
Polarimetry utilizes glucose to have stable polarized light property, and predict human blood glucose concentration by the deflection angle measuring transillumination (or reflected light), the shortcoming of the method is that deflection angle is less, measures difficulty large, and simultaneously because be measure human eye, patient not easily receives.The photoacoustic signal that photoacoustic spectroscopy method utilizes near-infrared laser pulse and tissue interaction to produce, the content of certain composition of organization internal is detected by the relation between the amplitude of photoacoustic signal and absorptance, the method is comparatively responsive to the change of organization internal structure, thus higher to the requirement of detector.Laser Raman spectrometry is the principle according to can there is Raman scattering when laser action is in glucose, utilize Raman spectrum analysis to obtain the concentration of glucose, due to absorption and the scattering effect of biological tissue, this signal detection, by other biological macromole serious interference, is still in the starting stage to In vivo study.Light scattering coefficient method is a kind of novel optics Non-invasive detection technology, and it is the scattered reflection light that detection space is differentiated, and calculates tissue simplification scattering coefficient, obtains the situation of change of component content in body by following the trail of the change simplifying scattering coefficient.Infrared spectrometry is also the principle of the concentration by calculating composition to be measured after Infrared Spectrum Technology process, remain at present choose at measuring condition, measuring point is selected, extract the critical problems such as faint semiochemical method in overlapped spectra needs to solve.Prior art also has the research of the non-invasive blood sugar instrument adopting microwave, but due in microwave measurement process, other factors for measurement impact greatly.
Summary of the invention
The technical problem that the present invention solves is: build a kind of microwave invasive blood sugar measuring system, overcomes prior art external factor to the technical problem measuring impact.
Technical scheme of the present invention is: provide a kind of microwave invasive blood sugar measuring system, comprise Microwave transceiver unit, microwave sounding unit, signal processing unit, output unit, described Microwave transceiver unit comprises microwave generation module, microwave receiving module, described microwave sounding unit connects described microwave generation module and described microwave receiving module, described microwave generation module through described microwave sounding unit to blood generation microwave signal to be measured, described microwave sounding unit is sent to described microwave receiving module and receives after receiving microwave signal, described microwave generation module occurrence frequency is 1GHz to 100GHz, the microwave signal that described signal processing unit receives according to described microwave receiving module obtains dielectric property value, dielectric property value is converted to blood sugar measured by described signal processing unit, described output unit exports blood sugar measured.
Further technical scheme of the present invention is: described microwave sounding unit be in microwave transmitting and receiving antenna, coaxial cable, waveguide transmission line any one.
Further technical scheme of the present invention is: described dielectric property value is:
or be:
, wherein:
represent dielectric property value,
angular frequency,
represent reflection coefficient,
represent reflection radian,
for the mould electricity energy storage that disappears in beginning place's coaxial line,
for the initial energy storage of coaxial circuit,
represent the output rating relevant with circuit.
Further technical scheme of the present invention is: described microwave transmitting and receiving antenna comprises microwave generation antenna, and described microwave generation antenna is multi-frequency micro-wave aerial array, the microwave of described multi-frequency micro-wave aerial array generation different frequency.
Further technical scheme of the present invention is: the microwave of each antenna generation different frequency in described multi-frequency micro-wave aerial array.
Further technical scheme of the present invention is: also comprise the duty detecting sensor be arranged on described microwave sounding unit.
Further technical scheme of the present invention is: also comprise correction module, and described correction module corrects according to the information of described duty detecting sensor sensing.
Further technical scheme of the present invention is: the blood glucose of described microwave sounding unit interval multi collect blood different frequency to be measured absorbs information.
Further technical scheme of the present invention is: described microwave transmitting and receiving antenna comprises microwave generation antenna and microwave antenna, described microwave generation antenna is microwave transmitting antenna array, described microwave antenna is microwave antenna array, and the single microwave antenna in the single microwave transmitting antenna in described microwave generation antenna array and described microwave antenna array successively interval is arranged.
Further technical scheme of the present invention is: the method that described signal processing unit adopts Mixture of expert algorithm and Madaline linear neural net to integrate is to process the signal of microwave antenna.
Technique effect of the present invention is: build a kind of microwave invasive blood sugar measuring system, comprise Microwave transceiver unit, microwave sounding unit, signal processing unit, output unit, described Microwave transceiver unit comprises microwave generation module, microwave receiving module, described microwave sounding unit connects described microwave generation module and described microwave receiving module, described microwave generation module through described microwave sounding unit to blood generation microwave signal to be measured, described microwave sounding unit is sent to described microwave receiving module and receives after receiving microwave signal, described microwave generation module occurrence frequency is 1GHz to 100GHz, the microwave signal that described signal processing unit receives according to described microwave receiving module obtains dielectric property value, dielectric property value is converted to blood sugar measured by described signal processing unit, described output unit exports blood sugar measured.Microwave invasive blood sugar measuring system of the present invention, collects microwave echoes information, obtains the dielectric property value of blood to be measured, then obtain corresponding blood glucose value by the dielectric property value of blood to be measured according to echo information.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention.
Fig. 2 is coaxial probe circuit diagram of the present invention.
Fig. 3 is that MOE and MADALINE of the present invention integrates neural net method schematic diagram.
Detailed description of the invention
Below in conjunction with specific embodiment, technical solution of the present invention is further illustrated.
As shown in Figure 1, the specific embodiment of the present invention is: build a kind of microwave invasive blood sugar measuring system, comprise Microwave transceiver unit 1, microwave sounding unit 2, signal processing unit 3, output unit 4, described Microwave transceiver unit 1 comprises microwave generation module 11, microwave receiving module 12, described microwave sounding unit comprises 2 microwave transmitting antenna 21, microwave antenna 22, described microwave transmitting antenna 21 connects described microwave generation module 11, described microwave sounding unit 2 connects described microwave receiving module 12, microwave signal is there is to region to be measured in described microwave generation module 11 through described microwave sounding unit 2, described microwave receiving module 12 is sent to after described microwave sounding unit 2 receives microwave signal, described microwave generation module 11 occurrence frequency is 1GHz to 100GHz, the microwave signal that described signal processing unit 3 receives according to described microwave receiving module 12 obtains dielectric property value, dielectric property value is converted to blood sugar measured by described signal processing unit 3, described output unit 4 exports blood sugar measured.Described microwave sounding unit 2 be in microwave transmitting and receiving antenna, coaxial cable, waveguide transmission line any one.
As shown in Figure 1, specific embodiment of the invention process is: described microwave generation module 11 occurrence frequency is 1GHz to 100GHz, described microwave sounding unit comprises 2 microwave transmitting antenna 21, microwave antenna 22, described microwave generation antenna 21 is microwave antenna array, described microwave antenna array generation microwave, utilizes the microwave of a branch of certain frequency to pass human body parts angiosomes.The blood glucose that described microwave antenna 22 interval gathers tissue different frequency several times absorbs information to respective passage, produces the signal of telecommunication, realizes opto-electronic conversion, complete the sampling of described microwave antenna.The signal of telecommunication that each passage photosensor arrays produces delivers to described signal processing unit 3, in described signal processing unit 3, be sent to that multichannel preamplifier carries out amplifying, filtering, Integral Processing, signal is made to reach amplitude and the signal to noise ratio of detection identification, the transformation of analogue signal to digital signal is realized again by A/D converter, digital signal after conversion delivers to the process that microprocessor carries out array signal, obtains dielectric property value, finally exports blood glucose value.Wave spectrum absorption/reflection characteristic special is separately had based on various material, utilize the wave spectrum absorption/reflection characteristic of blood glucose, just other material informations in its spectral information and blood can be made a distinction, simultaneously, blood glucose solution is in the special frequency channel of microwave, there is certain absorbing window and reflection windows, show in these wavelength band, by the measurement to the reflectance spectrum/absorption spectrum of microwave after blood glucose, can be more responsive to dielectric property according to its absorptance/reflection coefficient, therefore, finally can be passed through algorithm and perform the blood glucose concentration value drawing its correspondence.The art of this patent scheme is in order to overcome the difficult problem existed in microwave noninvasive dynamics monitoring, make the embodiment human blood glucose concentration that faint spectroscopic signal change energy is correct, devise multi-frequency micro-wave blood-sugar detection sensor array, the frequency separation measured is decided to be 1GHz-100GHz, specific frequency is segmented to each sensor in sensor array, again through the information of each sensor of detection model algorithm fusion, the precision and stability of microwave noninvasive dynamics monitoring is made to be improved like this.
Specific implementation process is as follows:
The preferred embodiment of the present invention is: described signal processing unit obtains the dielectric property value of blood to be measured according to the microwave signal that described microwave receiving module receives, and then obtains the blood sugar measured of blood to be measured according to the dielectric property value of blood to be measured.What adopt in the measuring process of non-invasive blood sugar instrument is that coaxial probe is measured, and the equivalent circuit of its dielectric constant measurement principle as shown in Figure 2.
As shown in Figure 2,
for the mould electricity energy storage that disappears in beginning place's coaxial line,
for the initial energy storage of coaxial circuit,
be the beginning place be diffused in stray capacitance in outside measured medium,
represent the output rating relevant with circuit, then the Linear Double capacitor model of upper figure can be expressed as:
By distortion:
Wherein:
represent dielectric property value,
angular frequency,
represent reflection coefficient,
represent reflection radian.
The method that described signal processing unit 3 adopts Mixture of expert algorithm and Madaline linear neural net to integrate is to process the signal of microwave antenna.
Data message between the human normal scope that Madaline Linear Network reception MOE transmits and GG, according to blood sugar test model, accuracy of detection, carry out linear approximation by dielectric property value W, calculate the blood glucose concentration value A of corresponding precision.Namely
Wherein weights W and parameter b obtain for benchmark carries out convergence computing with network minimum error quadratic sum, specifically using the GG of some different blood sugar concentration that obtains as the input of network, the same time is carried out successive iteration by the accurate blood glucose value of blood sample concentration as output accordingly and optimizes weights W, b until convergence can obtain.
As shown in Figure 1, the preferred embodiment of the present invention is: described microwave sounding unit comprises 2 microwave transmitting antenna 21, microwave antenna 22, described microwave generation module 11 occurrence frequency is 1GHz to 100GHz, described microwave generation antenna 21 is multi-frequency micro-wave aerial array, the microwave of described multi-frequency micro-wave aerial array generation different frequency, utilizes the microwave of a branch of certain frequency to pass human body parts angiosomes.The blood glucose that described microwave antenna 22 interval gathers tissue different frequency several times absorbs information to respective passage, produces the signal of telecommunication, realizes opto-electronic conversion, complete the sampling of described microwave antenna.In specific embodiment, the microwave of each antenna generation different frequency in described multi-frequency micro-wave aerial array.The design of microwave transmitting antenna array is according to detection model, and each sensor passage accepts the glucose wave spectrum reflected signal of different frequency scope.In order to reduce the effect of other factors affecting blood sugar test in human body, the multi-frequency micro-wave transmitting antenna array of design, the glucose absorption wave spectrum of different frequency scope is repeatedly detected with the sensor of multiple different frequency, message complementary sense, then through Array Signal Processing, draw blood glucose value more accurate than single-frequency microwave transmitting antenna array, meanwhile, work also can be stablized than single-frequency microwave transmitting antenna array.In measuring process, adopt multi-frequency micro-wave aerial array, the microwave of described multi-frequency micro-wave aerial array generation different frequency, make in microwave noninvasive dynamics monitoring process, reduce the impact of external factor, what obtain under different frequency is blood sugar measured, and the precision and stability of device measuring is improved.
As shown in Figure 1, the preferred embodiment of the present invention is: also comprise the duty detecting sensor 23 be arranged on described microwave sounding unit 2.In order to consider the change of the certainty of measurement that the factors such as the drift of response during microwave sounding cell operation and variations in temperature cause, on the basis adopting constant-current circuit stability microwave wave source, microwave sounding unit is provided with duty detecting sensor 23, the duty drift that temperature, sample variation etc. cause is controlled, duty is calibrated, monitors compensation, work with making sensor stabilization.The time that array is measured at every turn is about 5s, and the interval time of measuring during monitoring can set.Described signal processing unit 3 also comprises correction module 41, and described correction module corrects according to the information of described duty detecting sensor sensing 23.
As shown in Figure 1, the preferred embodiment of the present invention is: described microwave sounding unit 2 interval gathers the microwave echoes signal of region to be measured different frequency, the microwave echoes signal of region to be measured different frequency is gathered by interval, complete the collection repeatedly blood glucose in region to be measured being absorbed to information, the blood glucose value in region to be measured is obtained by obtaining its meansigma methods, more accurate like this.
As shown in Figure 1, the preferred embodiment of the present invention is: described microwave transmitting antenna 21 is microwave transmitting antenna array, described microwave antenna 22 is microwave antenna array, and the single microwave antenna in the single microwave transmitting antenna in described microwave transmitting antenna array and described microwave antenna array successively interval is arranged.Arranged by the interval successively of single microwave transmitting antenna and single microwave antenna, echo-signal can be obtained more easily.
As shown in Figure 1, Figure 3, because blood glucose is relevant with some physical factors of people itself, in order to obtain more accurate blood glucose value, need to correct some factors.In order to extract corresponding blood sugar concentration information from wave spectrum, obtain sufficiently high signal to noise ratio, to pick out faint glucose absorption signal from wave spectrum, certainty of measurement and the non-linear all reasonable method integrated by Mixture of expert algorithm (Mixture of Expert, MOE) and Madaline linear neural net is adopted to process array signal.
Mixture of expert algorithm can the comprehensive blood glucose spectral information of extraction comparison exactly, by Madaline linear neural net linear approximation methods, and the demarcation of process high accuracy blood glucose concentration value and display.Its algorithm is specific as follows:
Setting input parameter is
, four elements
be respectively body parameter,
represent sex, wherein, men's 1 represents, female is 0 expression;
represent human body correction factor;
represent quantity of motion correction factor;
represent the instrumental correction factor.Described microwave sounding unit be in microwave transmitting and receiving antenna, coaxial cable, waveguide transmission line any one.Four built-in elements
initialize according to the various factors of influence in detection model.The interference of the overlap of the wave spectrum of blood glucose in each channel wavelength and other factors except blood glucose can be eliminated, as the difference according to factor correction individualities such as age, height, body weight, can blood glucose information be made as far as possible accurate.
Each correction parameter
m test input parameter
linear sums add constant term
, that is:
The output of blood glucose ripple absorption parameter GG accurately records correction parameter by n sensor
summation, simultaneously each variable has a corresponding dielectric property value
, its relation is as follows:
Dielectric property value
with parameter
relevant, its expression formula is:
, wherein
.
Technique effect of the present invention is: build a kind of microwave invasive blood sugar measuring system, comprise Microwave transceiver unit 1, microwave sounding unit 2, signal processing unit 3, output unit 4, described Microwave transceiver unit 1 comprises microwave generation module 11, microwave receiving module 12, described microwave sounding unit comprises 2 microwave transmitting antenna 21, microwave antenna 22, described microwave transmitting antenna 21 connects described microwave generation module 11, described microwave antenna 22 connects described microwave receiving module 12, microwave signal is there is to region to be measured in described microwave generation module 11 through described microwave transmitting antenna 21, described microwave antenna 21 receives and is received by described microwave receiving module 12 after the microwave signal of area blood to be measured, described microwave generation module 11 occurrence frequency is 1GHz to 100GHz, the microwave signal that described signal processing unit 3 receives according to described microwave receiving module 12 obtains dielectric property value, dielectric property value is converted to blood sugar measured by described signal processing unit 3, described output unit 4 exports blood sugar measured.Microwave invasive blood sugar measuring system of the present invention, collects microwave spectrum information, obtains corresponding blood glucose value according to spectral data.In measuring process, adopt.This method multi-frequency micro-wave aerial array, the microwave of described multi-frequency micro-wave aerial array generation different frequency, makes in microwave noninvasive dynamics monitoring process, reduces the impact of external factor, what obtain under different frequency is blood sugar measured, and the precision and stability of device measuring is improved.
Above content is in conjunction with concrete preferred implementation further description made for the present invention, can not assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, some simple deduction or replace can also be made, all should be considered as belonging to protection scope of the present invention.
Claims (10)
1. a microwave invasive blood sugar measuring system, it is characterized in that, comprise Microwave transceiver unit, microwave sounding unit, signal processing unit, output unit, described Microwave transceiver unit comprises microwave generation module, microwave receiving module, described microwave sounding unit connects described microwave generation module and described microwave receiving module, described microwave generation module through described microwave sounding unit to blood generation microwave signal to be measured, described microwave sounding unit is sent to described microwave receiving module and receives after receiving microwave signal, described microwave generation module occurrence frequency is 1GHz to 100GHz, the microwave signal that described signal processing unit receives according to described microwave receiving module obtains dielectric property value, dielectric property value is converted to blood sugar measured by described signal processing unit, described output unit exports blood sugar measured.
2. microwave invasive blood sugar measuring system according to claim 1, is characterized in that, described microwave sounding unit be in microwave transmitting and receiving antenna, coaxial cable, waveguide transmission line any one.
3. microwave invasive blood sugar measuring system according to claim 1, it is characterized in that, described dielectric property value is:
or be:
, wherein:
represent dielectric property value,
angular frequency,
represent reflection coefficient,
represent reflection radian,
for the mould electricity energy storage that disappears in beginning place's coaxial line,
for the initial energy storage of coaxial circuit,
represent the output rating relevant with circuit.
4. microwave invasive blood sugar measuring system according to claim 2, it is characterized in that, described microwave transmitting and receiving antenna comprises microwave generation antenna, and described microwave generation antenna is multi-frequency micro-wave aerial array, the microwave of described multi-frequency micro-wave aerial array generation different frequency.
5. microwave invasive blood sugar measuring system according to claim 4, is characterized in that, the microwave of each antenna generation different frequency in described multi-frequency micro-wave aerial array.
6. microwave invasive blood sugar measuring system according to claim 1, is characterized in that, also comprise the duty detecting sensor be arranged on described microwave sounding unit.
7. microwave invasive blood sugar measuring system according to claim 6, it is characterized in that, also comprise correction module, described correction module corrects according to the information of described duty detecting sensor sensing.
8. microwave invasive blood sugar measuring system according to claim 1, is characterized in that, the blood glucose of described microwave sounding unit interval multi collect blood different frequency to be measured absorbs information.
9. microwave invasive blood sugar measuring system according to claim 2, it is characterized in that, described microwave transmitting and receiving antenna comprises microwave generation antenna and microwave antenna, described microwave generation antenna is microwave transmitting antenna array, described microwave antenna is microwave antenna array, and the single microwave antenna in the single microwave transmitting antenna in described microwave generation antenna array and described microwave antenna array successively interval is arranged.
10. microwave invasive blood sugar measuring system according to claim 1, is characterized in that, the method that described signal processing unit adopts Mixture of expert algorithm and Madaline linear neural net to integrate processes the signal of microwave antenna.
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