CN104887245A - Energy metabolic conservation method based wearing noninvasive glucometer - Google Patents
Energy metabolic conservation method based wearing noninvasive glucometer Download PDFInfo
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- CN104887245A CN104887245A CN201510247229.XA CN201510247229A CN104887245A CN 104887245 A CN104887245 A CN 104887245A CN 201510247229 A CN201510247229 A CN 201510247229A CN 104887245 A CN104887245 A CN 104887245A
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Abstract
The invention discloses an energy metabolic conservation method based wearing noninvasive glucometer. The glucometer is characterized by comprising an energy metabolic conservation glucose probe and a data acquisition unit and an internet data collection analysis unit which are connected with the energy metabolic conservation glucose probe. The glucose probe acquires data through the data acquisition unit, displays the data through an OLED in real time and sends the acquired data to the internet data collection analysis unit. The data acquisition unit performs operations of data insertion, updating, reading and the like on an internet database, and accordingly, human body glucose monitoring is achieved every time. By means of the glucometer, the detection probe with a plurality of sensors integrated is used for acquiring physiological signals required by energy metabolic conservation method noninvasive glucose detection, wearing design is achieved, the whole can operate stably smoothly, man-machine interaction is good, the glucometer is simple to operate, existing medical resources can be fully shared, and practical values are provided.
Description
Technical field
The invention belongs to medical instruments field, specifically a kind of Wearable Woundless blood sugar measuring method based on human energy metabolism conservation method.
Background technology
In recent years, the onset diabetes rate rate of climb is accelerated, and does not also effect a radical cure the method for diabetes at present, and the consumption mainly by detecting blood sugar concentration adjustment hypoglycemic medicine continually prevents or reduces the generation of complication.The finger blood-taking blood glucose meter of current employing has the danger of infection, and in the long run, this way may cause damaging finger tissue.In addition, the blood glucose meter of finger tip blood sampling is a centrifugal pump measuring device, during measurement, some hyperglycemia or hypoglycemic incidence rate may not be recorded, and therefore obtained Monitoring Data can not represent blood glucose integral status completely, therefore just seem particularly important to the research of noninvasive dynamics monitoring technology.
Blood sugar monitoring methods, from early stage biochemical blood sugar detecting method and Wicresoft's blood sugar detecting method, has now developed into Woundless blood sugar monitoring.Wicresoft's blood sugar test and biochemical blood sugar test are the detection meanss of present stage main flow, and technology also relative maturity, degree of accuracy is also high.Noninvasive dynamics monitoring is the benefit brought is mathematical, is the developing direction of blood glucose meter, can offers convenience to diabetes management, can provide foundation, for diabetics brings welfare to the control of the prevention of diabetes, treatment, blood glucose value.The non-invasive detection methods risen in recent years mainly contains the people such as Japanese Ok Kyung Cho and proposed in 2004 based on metabolic heat conformation method (Metabolic Heat Conformation, MHC) Noninvasive Blood Glucose Detection Methods, measuring accuracy does not but reach requirement.Tsing-Hua University Tang Fei etc. are based on metabolic heat conformation method and collaborative multiple physiological parameter have developed metabolic heat conformation method invasive blood sugar measuring system, and its measured value and true value correlation coefficient reach 0.856.The people such as the old sincerity of Guilin Electronic Science and Technology Univ. propose energy metabolism conservation method noninvasive dynamics monitoring technology, and the method, to the design of sensor and data processing algorithm are optimized, makes system measurement and true value correlation coefficient reach 0.87.The measuring principle of energy metabolism conservation method measures the physiological parameters such as body heat dissipation capacity, hemoglobin concentration, blood flow, blood oxygen saturation, by the final indirect Estimation blood glucose value of respective algorithm.
In manufacturing cost and the market price, have great advantage by the non-invasive blood-sugar detecting instrument of research design, can use various big hospital and basic health institute completely, more can enter family and use, its market is very huge.Then innovatory algorithm could the further accuracy rate improving blood sugar test to study its principle.
Summary of the invention
For the shortcoming of the portable degree deficiency of existing non-invasive blood sugar instrument, the invention provides a kind of Wearable non-invasive blood sugar instrument based on energy metabolism conservation method, this Wearable non-invasive blood sugar instrument in the physiological signal needed for detection probe collecting energy metabolism conservation method noninvasive dynamics monitoring integrally, realizes Wearable design by integrated multi-sensor.
The technical scheme realizing the object of the invention is:
A kind of Wearable non-invasive blood sugar instrument based on energy metabolism conservation method, comprise energy metabolism conservation method blood glucose probe and connected data acquisition equipment and internet data collection analysis equipment, blood glucose probe is by data acquisition equipment image data, and shown in real time by OLED, consider the problems such as some patient's vision, display result divided three kinds of colors to show, hyperglycemia adopts blue display by red display, euglycemia by green display, hypoglycemia.Finally the data collected are sent to internet data collection analysis equipment, then by data acquisition equipment, the operations such as data insertion, renewal, reading are carried out to internet database, thus realize blood sugar for human body monitoring at all times.
The temperature sensor be connected with master control system integral type by master control system in described energy metabolism conservation method probe, humidity sensor, the data gathered comprise ambient temperature, ambient humidity, space radiation temperature, finger surface temperature, finger surface humidity, finger surface radiation temperature, blood oxygen saturation, volume pulsation waveform data (under Infrared irradiation), by temperature sensor, humidity sensor, radiation thermometer (each two) and LED, PD is integrated in little collecting device, temperature sensor, humidity sensor, radiation thermometer will be accomplished to carry out data acquisition to two sides, during one side image data, the environment of another side can not affect this sensor reading.Temperature sensor can be affixed on outer surface, but humidity and radiation sensor will with surface a little distance.The material being affixed on body surface adopts soft material matter, well can be attached to the surface of measured object.Radiation sensor adopts diaphragm type thermal radiation sensor as far as possible.HONGGUANG infrared light wavelength: red-light LED-660nm infrared light LED-940nm.
Advantage of the present invention is: based on a large amount of clinical testing data, to various algorithm contrast verification repeatedly.Experimental result shows, and adopts random forest and BP neutral net two kinds of algorithms to coordinate revised blood sugar test accuracy rate to increase.The results relevance detected with Wicresoft detection method reaches 88.42%, and instrument is efficiently stable.Experimental Verification System meets Expected Results, and entirety can stablize smooth work, man-machine interaction is friendly, simple to operate, existing medical resource can be made fully shared, have practical value.It is theoretical that this research contributes to improving energy metabolism conservation method noninvasive dynamics monitoring, draw the relation of various crowd's metabolic rate, blood oxygen saturation, heart rate, blood flow rate and blood glucose, improve noninvasive dynamics monitoring accuracy rate, and be expected to this technology to be applied to clinical, realize the industrialization of non-invasive blood sugar instrument.
Accompanying drawing explanation
Fig. 1 is the structural representation of Wearable non-invasive blood sugar instrument of the present invention;
Fig. 2 is energy metabolism conservation method sensor integration structure chart;
Fig. 3 is humiture and raddiating circuit figure.
Detailed description of the invention
As shown in Figure 1.Based on the Wearable non-invasive blood sugar instrument of energy metabolism conservation method, comprise energy metabolism conservation method blood glucose probe and connected data acquisition equipment and internet data collection analysis equipment, blood glucose probe passes through data acquisition equipment, the data collected are sent to internet data collection analysis equipment, then by data acquisition equipment, the operations such as data insertion, renewal, reading are carried out to internet database, thus realize blood sugar for human body monitoring at all times.
As shown in Figure 2, master control system and Sensor section are integrated as Sensor section (unitary design) by energy metabolism conservation method probe designs, and in main system, function is integrated in sensor completely.Communication adopts Bluetooth communication, and is furnished with USB charging and communication interface, and USB adopts miniUSB interface, and system comprises two buttons, and one is detected button, forces power-off button for one.Other functions are controlled by bluetooth by embedded platform or smart mobile phone, structural design: each sensor space position inner wants rationally, to ensure that the data of each sensor acquisition are actual response parameters.The sensor measuring finger will be fitted finger, environmental sensor will and circuit board have some intervals, shield between each sensor and interact, and in shell, stay certain air-vent, guarantee measures true environment parameter.Opticator in internal structure, carries out lucifuge process.
Energy metabolism conservation method probe needs the data gathered to comprise ambient temperature, ambient humidity, space radiation temperature, finger surface temperature, finger surface humidity, finger surface radiation temperature, blood oxygen saturation, volume pulsation waveform data (under Infrared irradiation), by temperature sensor, humidity sensor, radiation thermometer (each two) and LED, PD are integrated in little collecting device, temperature sensor, humidity sensor, radiation thermometer will be accomplished to carry out data acquisition to two sides, and during one side image data, the environment of another side can not affect this sensor reading.Temperature sensor can be affixed on outer surface, but humidity and radiation sensor will with surface a little distance.The material being affixed on body surface adopts soft material matter, well can be attached to the surface of measured object.Radiation sensor adopts diaphragm type thermal radiation sensor as far as possible.HONGGUANG infrared light wavelength: red-light LED-660nm infrared light LED-940nm.
The data range collected and precision etc.: temperature (range :-15-45 degree Celsius, precision: 0.1 degree Celsius); Humidity (range: 0%-100%, precision: 0.1 %); Radiation (range: 0-45kW/m2, precision: 0.01 kW/m2.(DEG C)); Pulse wave (data) precision reach 12 and above (need consider because have sample rate, winter, women, finger have shake); Blood oxygen saturation (pulse intensity, pulse frequency, 1%, 70%-100%)
As shown in Figure 3, Temperature Humidity Sensor adopts TH02, and it contains relative humidity and temperature sensor exports with digital signal.The sensor element of the temperature and humidity of this integrated chip, contains analog/digital converter, signal processing circuit, calibration data and an I2C HPI.Adopt low-K dielectric polymer for detecting humidity, realize low-power consumption and detect, feature is low drifting, low sluggishness and long-time stability.Temperature and moisture sensors is factory calibrated and carries calibration data.Which ensure that sensor exchanges completely, without the need to any calibration or software modification.
Bluetooth circuit mainly completes data and is transferred to embedded platform and smart mobile phone from probe, is a kind of short-distance transmission.Photoelectricity drive circuit mainly completes the heart rate of human body, the detection of blood flow rate and blood oxygen saturation etc., drive circuit red-emitting infrared light wavelength: red-light LED-660nm infrared light LED-940nm, through finger by finger opposite side infrared receiver sensor receive, the optical signal now received contains the physiological parameter of finger, through analyzing the optical signal that receives and just can extrapolate the parameters such as the heart rate of finger, blood flow rate and blood oxygen saturation, in the pulse wave of finger, contain many valuable parameters.
Because acquisition abnormity blood glucose can not be issued guardian timely and cause serious consequence sometimes, such as hypoglycemia can cause patient's giddy to be lost consciousness, if guardian can not understand patient's present situation in time may have fatal risk.For making information can inform user timely and effectively, android mobile phone is adopted effectively to address this problem.Namely energy metabolism conservation method probe detects that data show in real time, adopts android mobile phone to carry out remote collection and monitoring to data simultaneously, makes it have portable and can monitor the features such as collection at any time.Major function has bluetooth connection, data acquisition, display and monitoring.
Mobile phone remote acquisition platform adopts Android phone to realize, it is the simplification of embedded monitoring platform, receive the data collected and be also connected to server realization to slave computer sending controling instruction by 3G wireless network, can in real time the data received be presented in android smart phone simultaneously.The Socket that the Socket method of standard can realize between any platform or any process communicates, utilize this characteristic just can realize the communication between linux system and Android system, the Android acquisition platform namely connected by 3G just can be carried out Socket with the standard Socket method that slave computer linux system collection terminal uses respective system to provide and communicate.What adopt is (namely Server is placed in slave computer linux system based on the Client/Server model of Transmission Control Protocol, and Client is placed in acquisition platform Android system, coding makes Client be connected to Server exchange data information).Linux system is built a TCP server, first create a Socket and utilize bind function to write on Socket by information such as IP addresses, then the monitoring event that used listen function to system registry, maximum number of connections is set, next be exactly the linking request waiting for that client is come, chain connects and just carries out exchanges data by send and recv function, has exchanged and must close network.On Android system develop a client, the first step is also will create a Socket and arrange the information such as IP address, is next exactly utilize connect function link server, below step build similar with TCP.
Noninvasive dynamics monitoring APP, refers to the application software based on the mobile terminal operating system such as Android intelligent, panel computer, and can be connected with Non-invasive detection hardware components transmission data.Major design main operation interface also can realize data acquisition, and user registers, and checks the operations such as history.
Data acquisition is connected with slave computer by Bluetooth pairing, APP can call local bluetooth adapter, opens Android client and carries bluetooth, completes the search to bluetooth equipment, by clicking slave computer Bluetooth address, carrying out coupling by standard overall situation unified identifier and connecting.After successful connection, by sending order, making slave computer start collection, analytical data, and completing data upload, and the parameters such as blood glucose, blood flow, blood oxygen, heart rate, systolic pressure, diastolic pressure are shown on UI.
During work,
1: energy metabolism conservation method Woundless blood sugar instrument probe records each physiological parameter of human body;
2: mobile phone A PP holds the data recorded by Bluetooth receptions energy metabolism conservation method Woundless blood sugar instrument probe;
3: mobile phone A PP by the Internet by data upload to data base, combine with large data, analyze blood glucose rule.
Claims (4)
1. the Wearable non-invasive blood sugar instrument based on energy metabolism conservation method, it is characterized in that: comprise energy metabolism conservation method blood glucose probe and connected data acquisition equipment and internet data collection analysis equipment, blood glucose probe is by data acquisition equipment image data, and shown in real time by OLED, finally the data collected are sent to internet data collection analysis equipment, then by data acquisition equipment, data insertion, renewal, reading are carried out to internet database.
2. Wearable non-invasive blood sugar instrument according to claim 1, is characterized in that: display result divides three kinds of colors to show, and hyperglycemia adopts blue display by red display, euglycemia by green display, hypoglycemia.
3. Wearable non-invasive blood sugar instrument according to claim 1, it is characterized in that: the temperature sensor be connected with master control system integral type by master control system in described energy metabolism conservation method probe, humidity sensor is formed, the data gathered comprise ambient temperature, ambient humidity, space radiation temperature, finger surface temperature, finger surface humidity, finger surface radiation temperature, blood oxygen saturation, volume pulsation waveform data, by temperature sensor, humidity sensor, radiation thermometer and LED, PD is integrated in little collecting device, temperature sensor, humidity sensor, radiation thermometer will be accomplished to carry out data acquisition to two sides, during one side image data, the environment of another side can not affect this sensor reading, temperature sensor can be affixed on outer surface, but humidity and radiation sensor will with surface a little distance, the material being affixed on body surface adopts soft material matter, well can be attached to the surface of measured object, HONGGUANG infrared light wavelength: red-light LED-660nm infrared light LED-940nm.
4. Wearable non-invasive blood sugar instrument according to claim 3, is characterized in that: described radiation sensor is diaphragm type thermal radiation sensor.
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| CN105962949A (en) * | 2016-06-14 | 2016-09-28 | 上海理工大学 | Noninvasive blood glucose calculating method based on near-infrared light energy conservation law and signal collecting device |
| CN106361305A (en) * | 2016-09-19 | 2017-02-01 | 爱国者电子科技有限公司 | Glucose metabolic rate measurement method and device |
| WO2018031161A1 (en) * | 2016-08-09 | 2018-02-15 | Verily Life Sciences Llc | Antenna configuration for compact glucose monitor |
| CN108272440A (en) * | 2018-01-24 | 2018-07-13 | 上海联影医疗科技有限公司 | Metabolic rate display methods, device, terminal and Medical Devices |
| CN110772264A (en) * | 2019-12-12 | 2020-02-11 | 桂林电子科技大学 | Quality control calibration device and calibration method based on GM-A type noninvasive glucometer |
| CN116172552A (en) * | 2023-03-03 | 2023-05-30 | 上海睿触科技有限公司 | Noninvasive glucometer and blood glucose detection method |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105962949A (en) * | 2016-06-14 | 2016-09-28 | 上海理工大学 | Noninvasive blood glucose calculating method based on near-infrared light energy conservation law and signal collecting device |
| WO2018031161A1 (en) * | 2016-08-09 | 2018-02-15 | Verily Life Sciences Llc | Antenna configuration for compact glucose monitor |
| US10938094B2 (en) | 2016-08-09 | 2021-03-02 | Verily Life Sciences Llc | Antenna configuration for compact glucose monitor |
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| US11605882B2 (en) | 2016-08-09 | 2023-03-14 | Verily Life Sciences Llc | Antenna configuration for compact glucose monitor |
| CN106361305A (en) * | 2016-09-19 | 2017-02-01 | 爱国者电子科技有限公司 | Glucose metabolic rate measurement method and device |
| CN108272440A (en) * | 2018-01-24 | 2018-07-13 | 上海联影医疗科技有限公司 | Metabolic rate display methods, device, terminal and Medical Devices |
| CN110772264A (en) * | 2019-12-12 | 2020-02-11 | 桂林电子科技大学 | Quality control calibration device and calibration method based on GM-A type noninvasive glucometer |
| CN116172552A (en) * | 2023-03-03 | 2023-05-30 | 上海睿触科技有限公司 | Noninvasive glucometer and blood glucose detection method |
| CN116172552B (en) * | 2023-03-03 | 2024-03-22 | 上海睿触科技有限公司 | Noninvasive glucometer and blood glucose detection method |
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Application publication date: 20150909 |