CN104856693B - Pulse blood holds the monitoring method and device of parameter - Google Patents
Pulse blood holds the monitoring method and device of parameter Download PDFInfo
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- CN104856693B CN104856693B CN201510197760.0A CN201510197760A CN104856693B CN 104856693 B CN104856693 B CN 104856693B CN 201510197760 A CN201510197760 A CN 201510197760A CN 104856693 B CN104856693 B CN 104856693B
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- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
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- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
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- A—HUMAN NECESSITIES
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Abstract
The present invention is suitable for medical monitoring technical field, provides monitoring method and device that pulse blood holds parameter.The method includes：Wherein, at least two-way pulse wave signal is corresponding with the optical signal of at least two-way different wave length respectively for at least two-way pulse wave signal of acquisition human body appointed part；Determine that the pulse blood holds parameter according at least two-way pulse wave signal and pre-set factory group.The present invention is by being analyzed and being calculated at least two-way pulse wave signal, to realize the continuous monitoring for holding parameter to pulse blood；By obtaining at least two-way optical signal transmissive after arteries of the light of at least two-way different wave length by human body appointed part, and then obtain at least two-way pulse wave signal, influence of the substance in addition to hemoglobin for measurement result is thereby eliminated, it is achieved thereby that holding the accurate measurement of parameter for pulse blood.
Description
Technical field
The invention belongs to the monitoring methods and device that medical monitoring technical field more particularly to pulse blood hold parameter.
Background technology
The most important function of blood circulation is the matter transportation in perfect aspect, by nutrient and oxygen transportation in vivo each
In tissue, to participate in the metabolic activity of cell.Endoerythrocytic hemoglobin is the main carriers for transporting oxygen, and blood red
The quantity of albumen determines oxygen transportation ability.The oxygen demand of human body end flap or organ (such as head or finger) compared with
Height if oxygen supply capacity is insufficient so that less than normal level, can cause the metabolism of tissue or organ normal
Carry out, these tissue or organ may therefore major injury or even threat to life.
The Oxygen supplied level of human body is determined by the oxyhemoglobin amount in artery.And mainly pass through in the prior art
Blood oxygen saturation weighs the Oxygen supplied level of human body, this mode for the weighing result of supplying oxygen to body level accuracy compared with
It is low.This is because what blood oxygen saturation represented is ratio that oxyhemoglobin in hemoglobin accounts for total hemoglobin, blood oxygen
The height of saturation degree only represents the opposite height of oxyhemoglobin.That is, human body blood oxygen saturation normally illustrates human body
Respiratory function is normal and oxygen supply is sufficient, but does not represent that human body hemoglobin content is normal, such as some postoperative anemias patient
Blood oxygen saturation is normal but hemoglobin content is relatively low.Therefore, by blood oxygen saturation it is difficult to accurately weigh the oxygen supply water of human body
Flat, in real time, continuously monitoring pulse hemoglobin content is particularly important.
It exists in the prior art and blood red egg is weighed using the AC compounent of single channel pulse signal and the ratio of DC component
The technical solution measured in vain, however, variation and the blood oxygen saturation of the ratio of the AC compounent and DC component of single channel pulse signal
Variation it is corresponding, equally exist for the measurement accuracy of hemoglobin content it is relatively low the problem of.
Invention content
In consideration of it, an embodiment of the present invention provides a kind of continuous monitoring method and device of pulse hemoglobin, to solve
The prior art for the measurement accuracy of hemoglobin content it is relatively low the problem of.
On the one hand, an embodiment of the present invention provides a kind of pulse blood hold parameter monitoring method, including：
At least two-way pulse wave signal of human body appointed part is obtained, wherein, at least two-way pulse wave signal difference
It is corresponding with the optical signal of at least two-way different wave length；
Determine that the pulse blood holds parameter according at least two-way pulse wave signal and pre-set factory group.
Wherein, the pulse blood holds parameter and includes pulse hemoglobin content；
At least two-way pulse wave signal and pre-set factory group determine that the pulse blood holds parameter and includes described in the basis：
The blood red egg of the pulse is determined according to the signal strength of at least two-way pulse wave signal and pre-set factory group
Bai Liang.
Wherein, the pulse blood appearance parameter further includes average pulse hemoglobin content；
At least two-way pulse wave signal and pre-set factory group determine that the pulse blood holds parameter and also wraps described in the basis
It includes：
The average pulse is calculated according to the determining pulse hemoglobin content and the pulse hemoglobin content of storage
Hemoglobin content.
Wherein, the pulse blood appearance parameter further includes average pulse oxyhemoglobin amount；
At least two-way pulse wave signal and pre-set factory group determine that the pulse blood holds parameter and also wraps described in the basis
It includes：
The blood oxygen saturation of at least two-way pulse wave signal is determined respectively；
It is red that the average pulse oxygenated blood is calculated according to the average pulse hemoglobin content and the blood oxygen saturation
Protein content.
Wherein, before at least two-way pulse wave signal for obtaining human body appointed part, the method further includes：
The pre-set factory group is determined by titrating to be fitted.
Second aspect, an embodiment of the present invention provides a kind of pulse blood hold parameter monitoring device, including：
Pulse wave signal acquiring unit, for obtaining at least two-way pulse wave signal of human body appointed part, wherein, it is described
At least two-way pulse wave signal is corresponding with the optical signal of at least two-way different wave length respectively；
Pulse blood holds parameter determination unit, is determined for at least two-way pulse wave signal and pre-set factory group according to
The pulse blood holds parameter.
Wherein, the pulse blood holds parameter and includes pulse hemoglobin content；
The pulse blood holds parameter determination unit and includes：
Pulse hemoglobin content determination subelement, for according to described at least the signal strength of two-way pulse wave signal and
Pre-set factory group determines the pulse hemoglobin content.
Wherein, the pulse blood appearance parameter further includes average pulse hemoglobin content；
The pulse blood holds parameter determination unit and further includes：
Average pulse hemoglobin content determination subelement, for according to the determining pulse hemoglobin content and storage
Pulse hemoglobin content calculate the average pulse hemoglobin content.
Wherein, the pulse blood appearance parameter further includes average pulse oxyhemoglobin amount；
The pulse blood holds parameter determination unit and further includes：
Blood oxygen saturation determination subelement, for determining the blood oxygen saturation of at least two-way pulse wave signal respectively；
Average pulse oxyhemoglobin amount determination subelement, for according to the average pulse hemoglobin content and institute
It states blood oxygen saturation and calculates the average pulse oxyhemoglobin amount.
Wherein, described device further includes：
Pre-set factory group determination unit determines the pre-set factory group for passing through titration fitting.
Existing advantageous effect is the embodiment of the present invention compared with prior art：The embodiment of the present invention is by being positioned over human body
The blood oxygen transducer acquisition at least two-way pulse wave signal of appointed part, is analyzed and is counted at least two-way pulse wave signal
It calculates, to realize the continuous monitoring for holding parameter to pulse blood；Human body appointed part is passed through by the light of at least two-way different wave length
Arteries after obtain at least two-way optical signal transmissive, and then obtain at least two-way pulse wave signal, thereby eliminate except blood
Influence of the substance for measurement result other than Lactoferrin, it is achieved thereby that holding the accurate measurement of parameter for pulse blood.
Description of the drawings
It to describe the technical solutions in the embodiments of the present invention more clearly, below will be to embodiment or description of the prior art
Needed in attached drawing be briefly described, it should be apparent that, the accompanying drawings in the following description be only the present invention some
Embodiment, for those of ordinary skill in the art, without having to pay creative labor, can also be according to these
Attached drawing obtains other attached drawings.
Fig. 1 is the realization flow chart for the monitoring method that pulse blood provided in an embodiment of the present invention holds parameter；
Fig. 2 is to obtain human body described in the monitoring method step S101 of pulse blood appearance parameter provided in an embodiment of the present invention to specify
The specific implementation flow chart of at least two-way pulse wave signal at position；
Fig. 3 is the structure diagram for the monitoring device that pulse blood provided in an embodiment of the present invention holds parameter.
Specific embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to the accompanying drawings and embodiments, it is right
The present invention is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, and
It is not used in the restriction present invention.
Fig. 1 shows that pulse blood provided in an embodiment of the present invention holds the realization flow chart of the monitoring method of parameter, is described in detail such as
Under：
In step S101, at least two-way pulse wave signal of human body appointed part is obtained, wherein, at least two-way arteries and veins
Wave signal of fighting is corresponding with the optical signal of at least two-way different wave length respectively.
Wherein, human body appointed part can be end finger artery, arteria carotis or forehead artery etc., not limit herein
It is fixed.Wherein, pulse wave signal stabilization refers to that the quality of optical signal transmissive (or reflected light signal) is more steady, without larger
Fluctuation.
In step s 102, determine that the pulse blood holds according at least two-way pulse wave signal and pre-set factory group
Parameter.
Pulse blood in the embodiment of the present invention holds parameter and passes through tissue by the optical signal of at least two-way different wave length
The pulse wave signal of medium vessels obtains.Pulse blood holds parameter and mainly reflects the blood volumes such as blood perfusion level, pulse hemoglobin
Correlation properties.Pulse blood holds parameter and includes but not limited to pulse hemoglobin content, the ginsengs such as pulse hemoglobin content and blood oxygen, blood pressure
The parameter of the blood volumes such as several combinations or other reflection blood perfusion level, pulse hemoglobins.
Preferably, the pulse blood holds parameter and includes pulse hemoglobin content；
At least two-way pulse wave signal and pre-set factory group determine that the pulse blood holds parameter and includes described in the basis：
The blood red egg of the pulse is determined according to the signal strength of at least two-way pulse wave signal and pre-set factory group
Bai Liang.
The parameter of traditional measurement blood perfusion degree is PI (Perfusion Index, blood perfusion index), is passed through
The AC compounent of single channel pulse signal and the ratio of DC component are worth to.And blood oxygen saturation is to calculate pulse wave letter all the way respectively
Number AC compounent and DC component ratio r1With the in addition ratio of the AC compounent of pulse wave signal and DC component all the way
r2, then the ratio by the twoIt is obtained by certain operation.When blood oxygen saturation changes, wherein pulse wave all the way
The AC compounent of signal and the ratio of DC component necessarily change, and therefore, PI is become according to the variation of blood oxygen saturation
Change.And the pulse hemoglobin content in the embodiment of the present invention is calculated by the signal strength of at least two-way pulse wave signal
R and corresponding pre-set factory with reference to and obtain, be mutually independent with blood oxygen saturation.Therefore, by of the invention real
Apply the pulse hemoglobin content that example obtains is not influenced by blood oxygen saturation.
It should be noted that pulse blood is determined according at least signal strength of two-way pulse wave signal and pre-set factory group
The mode of Lactoferrin amount is not limited to above-mentioned calculation.
The embodiment of the present invention, which is realized, to be carried out patient by noninvasive method in real time, continuously monitoring, in the arteries and veins of patient
During hemoglobin content suddenly change of fighting, alarm can be provided in time, and medical staff is helped to react in time.
Blood oxygen transducer can be positioned over human body end by the embodiment of the present invention, so as to calculate the blood red egg of the pulse of human body end
Bai Liang.Since when hemoglobin content occurs abnormal in human body, human body end will appear corresponding variation first, therefore, pass through
The supply capacity of substance needed for human body oxygen and other metabolism can be reflected in time by calculating the pulse hemoglobin content of human body end.
The pulse hemoglobin content that the embodiment of the present invention obtains can reflect the hemoglobin level of human body end.Actually should
In, the embodiment of the present invention can be applied to monitor lose blood situation or head in patient's surgical procedure (especially organ transfer operation)
Blood supply situation, with to when carry out blood transfusion play the role of auxiliary direction.The embodiment of the present invention can also be applied to patient's fluid infusion
In management, prevent the patient originally in state of losing blood from tissue being caused to supply hypoxgia because of pulse hemoglobin content decline after fluid infusion.
The embodiment of the present invention is carried out multiple using the signal strength of at least two-way pulse wave signal in combination with pre-set factory
Pulse hemoglobin content is evaluated in the fitting of power, when thus constant in blood constituent and peripheral circulation function does not change, blood
The variation of oxygen saturation will not have an impact the pulse hemoglobin content calculated.
Preferably, the pulse blood appearance parameter further includes average pulse hemoglobin content；
At least two-way pulse wave signal and pre-set factory group determine that the pulse blood holds parameter and also wraps described in the basis
It includes：
The average pulse is calculated according to the determining pulse hemoglobin content and the pulse hemoglobin content of storage
Hemoglobin content.
As one embodiment of the present of invention, after pulse hemoglobin content is calculated, pulse hemoglobin content is stored.
Wherein, pulse hemoglobin content of the pulse hemoglobin content of storage for the first preset time memory storage before this.When first default
When time is longer, available for calculating the average pulse hemoglobin content of long period.When the first preset time is longer, average arteries and veins
Fight hemoglobin content changing sensitivity it is relatively low, be applicable in resuming treatment.When the first preset time is shorter, available for counting
Calculate the average pulse hemoglobin content of short period.When the first preset time is shorter, the variation of average pulse hemoglobin content
Sensitivity is higher, is applicable in operation.
Optionally, the method further includes：Store the pulse hemoglobin content being calculated and the blood red egg of average pulse
Bai Liang, and show the pulse hemoglobin content being calculated and average pulse hemoglobin content.Specifically, can become according to the time
Change pulse hemoglobin content and the average pulse hemoglobin content that display is calculated, the pulse being calculated with real-time display
The variation tendency of hemoglobin content and average pulse hemoglobin content.Optionally, by the blood red egg of the average pulse being calculated
White amount is compared with history value, if the absolute value of the difference of average pulse hemoglobin content and history value is more than first threshold,
It then alarms, medical staff to be prompted to carry out medical treatment in time.
Preferably, the pulse blood appearance parameter further includes average pulse oxyhemoglobin amount；
At least two-way pulse wave signal and pre-set factory group determine that the pulse blood holds parameter and also wraps described in the basis
It includes：
The blood oxygen saturation of at least two-way pulse wave signal is determined respectively；
It is red that the average pulse oxygenated blood is calculated according to the average pulse hemoglobin content and the blood oxygen saturation
Protein content.
Optionally, average pulse oxygenated blood red eggs are calculated according to the average pulse hemoglobin content and blood oxygen saturation
White amount obtains average pulse oxyhemoglobin specifically, the product of calculating average pulse hemoglobin content and blood oxygen saturation
Amount.It should be noted that can also average arteries and veins be obtained with reference to average pulse hemoglobin content and blood oxygen saturation by other send
It fights oxyhemoglobin amount, is not limited thereto.
Since blood oxygen saturation reflection pulse oxyhemoglobin amount accounts for the ratio of total hemoglobin, and the blood red egg of pulse
There are identity relations with total hemoglobin for white amount, therefore, utilize average pulse hemoglobin content and the product of blood oxygen saturation
Average pulse oxyhemoglobin amount is obtained, the interference of uncorrelated phoneme can be eliminated, it is red to obtain accurate average pulse oxygenated blood
Protein content, while operand, speed up processing can be reduced.
The embodiment of the present invention can be applied to monitoring patient and specify by the way that pulse hemoglobin content is combined with blood oxygen saturation
The variation of position pulse oxyhemoglobin amount.For example, the infant head of monitoring asphyxia recovery, and then to recovery quality of suffocating
It judges.For another example numb recovery caused by monitoring patient limb long term hypoxia, and then recovery quality is judged.Arteries and veins
Oxyhemoglobin amount of fighting may further be used to the Status of Anemia of monitoring patient.Assuming that human body appointed part is forehead artery, then by volume
The pulse hemoglobin content of cephalic artery is combined with blood oxygen saturation, can reflect the variation of the oxyhemoglobin of brain tissue.
Hold Fig. 2 shows pulse blood provided in an embodiment of the present invention and obtain human body described in the monitoring method step S101 of parameter
The specific implementation flow chart of at least two-way pulse wave signal of appointed part, with reference to Fig. 2：
At least two-way pulse wave signal for obtaining human body appointed part includes：
In step s 201, the incident optical signal of at least two-way different wave length is sent out by blood oxygen transducer, is received at least
At least two-way optical signal transmissive after arteries of the two-way incident optical signal by the human body appointed part, and by described in extremely
Few two-way optical signal transmissive is converted at least two-way current signal；
In step S202, at least two-way current signal is converted at least two-way voltage signal, to it is described at least
Two-way voltage signal carries out signal amplification, and the amplified at least two-way voltage signal is converted to digital signal, obtains
At least two-way pulse wave signal.
In embodiments of the present invention, by blood oxygen transducer docile or after being sandwiched in human body appointed part, pass through blood oxygen transducer
In luminescent device send out the incident optical signal of at least two-way different wave length, after the arteries by human body appointed part, by
Photoelectric receiving device in blood oxygen transducer receives at least two-way optical signal transmissive (or reflected light signal), and will at least two-way
Optical signal transmissive is converted at least two-way current signal.Wherein, at least the incident light of two-way different wave length can include feux rouges with
Infrared light is not limited thereto.
When arteriopalmus vasodilation, the optical path length of arterial blood increases Δ d, correspondingly, transmitted intensity
It changes.By taking two-way light as an example, it is assumed that two-way light is respectively feux rouges and infrared light, and the wavelength of feux rouges is λ1, the wave of infrared light
A length of λ2, feux rouges is I through the transmitted intensity after the artery of periodic pulses1, after the artery of infrared light periodic pulses
Transmitted intensity be I2, then according to I1、I2The blood oxygen saturation SpO of human body appointed part can be obtained with Δ d2.Blood oxygen saturation
With I1、I2There are mapping relations F, SpO between Δ d2=F (I1,I2,Δd).Δ d represent arterial blood due to heartbeat with
And cardiac cycle diastole, the light path knots modification for shrinking generation, there are fixed ratios for Δ d and arterial vascular diameter.F and two
The absorptivity of the light of road different wave length is related, and for specific oxygen saturation measurement equipment, F is known.
At least two-way voltage signal at least will be converted to by two-way current signal by a series of hardware circuit, at least two
Road voltage signal carries out signal amplification, and amplified at least two-way voltage signal is converted to digital signal, obtains at least two
Contain the digital signal of pulse wave information to get at least two-way pulse wave signal in road.
Optionally, before step S102, the method further includes：Obtain pressure value.Pulse blood hold parameter further include through
Pulse hemoglobin content after blood pressure value calibration.At least two-way pulse wave signal and pre-set factory group determines described in the basis
The pulse blood holds parameter and includes：It is calculated according to the signal strength pre-set factory group of at least two-way pulse wave signal and pressure value
Pulse hemoglobin content after blood pressure value calibration.Since the peripheral blood vessel cycle of human body changes, (such as caliber is shunk or pipe
Wall elasticity weakens etc.) it can reflect in pressure value, and the peripheral blood vessel of human body cycle changes and can also influence the blood red egg of pulse
Bai Liang, therefore obtained by way of fitting of a polynomial using blood pressure as variable in the calculation formula of pulse hemoglobin content
More accurate pulse hemoglobin content, the peripheral blood vessel for eliminating human body recycle the influence for changing and bringing.
Preferably, before step S101, this method further includes：
The pre-set factory group is determined by titrating to be fitted.
In embodiments of the present invention, determine that the pre-set factory group is specially by titrating to be fitted：Keep the blood red egg of pulse
It is white to measure as preset value, continuous L change blood oxygen saturation, L+1 different blood oxygen saturations of acquisition, and acquisition and L+1 respectively
The signal strength of the corresponding L+1 groups of a different blood oxygen saturation at least two-way pulse wave signal, wherein, L is whole more than N
Number；According to preset value, the L+1 different blood oxygen saturations corresponding at least two of different blood oxygen saturations and L+1
The signal strength of road pulse wave signal calculates to obtain L+1 initial coefficients group, each initial in the L+1 initial coefficients group
Coefficient sets include N+1 coefficient；The L+1 initial coefficients group is fitted according to least square method, obtains pre-set factory
Group, the pre-set factory group include N+1 pre-set factory.
In the following, the embodiment of the present invention is illustrated for being equal to 7, N equal to 4 with L.It should be noted that N is bigger,
It is higher for the counting accuracy of pulse hemoglobin content.
In embodiments of the present invention, it is preset value to keep pulse hemoglobin content, and continuous 7 changes blood oxygen saturation obtains
To 8 blood oxygen saturations, and the signal strength of the corresponding 8 groups of at least two-way pulse wave signals of 8 blood oxygen saturations is obtained respectively.
It is strong according to the signal of preset value, 8 blood oxygen saturations and the corresponding 8 groups of at least two-way pulse wave signals of 8 blood oxygen saturations
8 initial coefficients groups are calculated in degree.8 initial coefficients groups are fitted, obtain pre-set factory group.
It should be understood that in embodiments of the present invention, the size of the serial number of above-mentioned each process is not meant to the elder generation of execution sequence
Afterwards, the execution sequence of each process should be determined with its function and internal logic, the implementation process structure without coping with the embodiment of the present invention
Into any restriction.
The embodiment of the present invention acquires at least two-way pulse wave signal by being positioned over the blood oxygen transducer of human body appointed part,
At least two-way pulse wave signal is analyzed and calculated, to realize the continuous monitoring for holding parameter to pulse blood；Pass through at least two
The light of road different wave length obtains at least two-way optical signal transmissive after the arteries by human body appointed part, so obtain to
Few two-way pulse wave signal, thereby eliminates influence of the substance in addition to hemoglobin for measurement result, it is achieved thereby that
Hold the accurate measurement of parameter for pulse blood.
Fig. 3 shows that pulse blood provided in an embodiment of the present invention holds the structure diagram of the monitoring device of parameter, which can
Hold the monitoring method of parameter for the pulse blood described in service chart 1 or Fig. 2.For convenience of description, it illustrates only and the present invention
The relevant part of embodiment.With reference to Fig. 3, described device includes：
Pulse wave signal acquiring unit 31, for obtaining at least two-way pulse wave signal of human body appointed part, wherein, institute
It is corresponding with the optical signal of at least two-way different wave length respectively to state at least two-way pulse wave signal；
Pulse blood holds parameter determination unit 32, true for at least two-way pulse wave signal and pre-set factory group according to
The fixed pulse blood holds parameter.
Preferably, the pulse blood holds parameter and includes pulse hemoglobin content；
The pulse blood holds parameter determination unit 32 and includes：
Pulse hemoglobin content determination subelement 321, for the signal strength of at least two-way pulse wave signal according to
And pre-set factory group determines the pulse hemoglobin content.
Preferably, the pulse blood appearance parameter further includes average pulse hemoglobin content；
The pulse blood holds parameter determination unit 32 and further includes：
Average pulse hemoglobin content determination subelement 322, for according to the determining pulse hemoglobin content and
The pulse hemoglobin content of storage calculates the average pulse hemoglobin content.
Preferably, the pulse blood appearance parameter further includes average pulse oxyhemoglobin amount；
The pulse blood holds parameter determination unit 32 and further includes：
Blood oxygen saturation determination subelement 323, for determining the blood oxygen saturation of at least two-way pulse wave signal respectively
Degree；
Average pulse oxyhemoglobin amount determination subelement 324, for according to the average pulse hemoglobin content with
And the blood oxygen saturation calculates the average pulse oxyhemoglobin amount.
Preferably, described device further includes：
Pre-set factory group determination unit 33 determines the pre-set factory group for passing through titration fitting.
The embodiment of the present invention acquires at least two-way pulse wave signal by being positioned over the blood oxygen transducer of human body appointed part,
At least two-way pulse wave signal is analyzed and calculated, to realize the continuous monitoring for holding parameter to pulse blood；Pass through at least two
The light of road different wave length obtains at least two-way optical signal transmissive after the arteries by human body appointed part, so obtain to
Few two-way pulse wave signal, thereby eliminates influence of the substance in addition to hemoglobin for measurement result, it is achieved thereby that
Hold the accurate measurement of parameter for pulse blood.
Those of ordinary skill in the art may realize that each exemplary lists described with reference to the embodiments described herein
Member and algorithm steps can be realized with the combination of electronic hardware or computer software and electronic hardware.These functions are actually
It is performed with hardware or software mode, specific application and design constraint depending on technical solution.Professional technician
Described function can be realized using distinct methods to each specific application, but this realization is it is not considered that exceed
The scope of the present invention.
It is apparent to those skilled in the art that for convenience and simplicity of description, the device of foregoing description
With the specific work process of unit, the corresponding process in preceding method embodiment can be referred to, details are not described herein.
In several embodiments provided herein, it should be understood that disclosed device and method can pass through it
Its mode is realized.For example, the apparatus embodiments described above are merely exemplary, for example, the division of the unit, only
Only a kind of division of logic function can have other dividing mode in actual implementation, such as multiple units or component can be tied
It closes or is desirably integrated into another system or some features can be ignored or does not perform.Another point, it is shown or discussed
Mutual coupling, direct-coupling or communication connection can be by some interfaces, the INDIRECT COUPLING or communication link of unit
It connects, can be electrical, machinery or other forms.
The unit illustrated as separating component may or may not be physically separate, be shown as unit
The component shown may or may not be physical unit, you can be located at a place or can also be distributed to multiple
In network element.Some or all of unit therein can be selected according to the actual needs to realize the mesh of this embodiment scheme
's.
In addition, each functional unit in each embodiment of the present invention can be integrated in a processing unit, it can also
That each unit is individually physically present, can also two or more units integrate in a unit.
If the function is realized in the form of SFU software functional unit and is independent product sale or in use, can be with
It is stored in a computer read/write memory medium.Based on such understanding, technical scheme of the present invention is substantially in other words
The part contribute to the prior art or the part of the technical solution can be embodied in the form of software product, the meter
Calculation machine software product is stored in a storage medium, is used including some instructions so that a computer equipment (can be
People's computer, server or network equipment etc.) perform all or part of the steps of the method according to each embodiment of the present invention.
And aforementioned storage medium includes：USB flash disk, mobile hard disk, read-only memory (ROM, Read-Only Memory), arbitrary access are deposited
The various media that can store program code such as reservoir (RAM, Random Access Memory), magnetic disc or CD.
The above description is merely a specific embodiment, but protection scope of the present invention is not limited thereto, any
Those familiar with the art in the technical scope disclosed by the present invention, can readily occur in change or replacement, should all contain
Lid is within protection scope of the present invention.Therefore, protection scope of the present invention described should be subject to the protection scope in claims.
Claims (8)
1. a kind of pulse blood holds the monitoring method of parameter, which is characterized in that including：
Obtain human body appointed part at least two-way pulse wave signal, wherein, at least two-way pulse wave signal respectively with extremely
The optical signal of few two-way different wave length corresponds to；
Determine that the pulse blood holds parameter according at least two-way pulse wave signal and pre-set factory group；
The pulse blood holds parameter and includes pulse hemoglobin content, and the calculation formula of the pulse hemoglobin content is：
Q=[f (I1,I2...Im)+λm]·g(Am,n,Rm)
Wherein, Q represents pulse hemoglobin content, and m represents the number using light path, mapping relationship f (I1,...Im) be represented byWherein IkFor the signal strength on kth road, a0,a1,a2,…,aMFor
Constant, λmFor calibration factor, and M >=2,Wherein Rk=rk-1/rk, Am,nWhen representing m roads
Pre-set factory, Am,0,Am,1,Am,2...Am,NForm pre-set factory group, N is integer more than or equal to 1, rkRepresent kth road arteries and veins
It fights the alternating current-direct current ratio of wave signal.
2. the method as described in claim 1, which is characterized in that the pulse blood holds parameter and further includes average pulse hemoglobin
Amount；
At least two-way pulse wave signal and pre-set factory group determine that the pulse blood holds parameter and further includes described in the basis：
It is blood red that the average pulse is calculated according to the determining pulse hemoglobin content and the pulse hemoglobin content of storage
Protein content.
3. method as claimed in claim 2, which is characterized in that it is red that the pulse blood appearance parameter further includes average pulse oxygenated blood
Protein content；
At least two-way pulse wave signal and pre-set factory group determine that the pulse blood holds parameter and further includes described in the basis：
The blood oxygen saturation of at least two-way pulse wave signal is determined respectively；
The average pulse oxyhemoglobin is calculated according to the average pulse hemoglobin content and the blood oxygen saturation
Amount.
4. the method as described in claim 1, which is characterized in that in at least two-way pulse wave for obtaining human body appointed part
Before signal, the method further includes：
The pre-set factory group is determined by titrating to be fitted.
5. a kind of pulse blood holds the monitoring device of parameter, which is characterized in that including：
Pulse wave signal acquiring unit, for obtaining at least two-way pulse wave signal of human body appointed part, wherein, it is described at least
Two-way pulse wave signal is corresponding with the optical signal of at least two-way different wave length respectively；
Pulse blood holds parameter determination unit, described at least two-way pulse wave signal and pre-set factory group determine according to
Pulse blood holds parameter；
The pulse blood holds parameter and includes pulse hemoglobin content；
The pulse blood holds parameter determination unit and includes：
Pulse hemoglobin content determination subelement, for at least signal strength of two-way pulse wave signal and preset according to
Coefficient sets determine the pulse hemoglobin content, and the calculation formula of the pulse hemoglobin content is：
Q=[f (I1,I2...Im)+λm]·g(Am,n,Rm)
Wherein, Q represents pulse hemoglobin content, and m represents the number using light path, mapping relationship f (I1,...Im) be represented byWherein IkFor the signal strength on kth road, a0,a1,a2,…,aMFor
Constant, λmFor calibration factor, and M >=2,Wherein Rk=rk-1/rk, Am,nWhen representing m roads
Pre-set factory, Am,0,Am,1,Am,2...Am,NForm pre-set factory group, N is integer more than or equal to 1, rkRepresent kth road arteries and veins
It fights the alternating current-direct current ratio of wave signal.
6. device as claimed in claim 5, which is characterized in that the pulse blood holds parameter and further includes average pulse hemoglobin
Amount；
The pulse blood holds parameter determination unit and further includes：
Average pulse hemoglobin content determination subelement, for the arteries and veins according to the determining pulse hemoglobin content and storage
Hemoglobin content of fighting calculates the average pulse hemoglobin content.
7. device as claimed in claim 6, which is characterized in that it is red that the pulse blood appearance parameter further includes average pulse oxygenated blood
Protein content；
The pulse blood holds parameter determination unit and further includes：
Blood oxygen saturation determination subelement, for determining the blood oxygen saturation of at least two-way pulse wave signal respectively；
Average pulse oxyhemoglobin amount determination subelement, for according to the average pulse hemoglobin content and the blood
Average pulse oxyhemoglobin amount described in oxygen saturation calculation.
8. device as claimed in claim 5, which is characterized in that described device further includes：
Pre-set factory group determination unit determines the pre-set factory group for passing through titration fitting.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1444906A (en) * | 2002-03-16 | 2003-10-01 | 三星电子株式会社 | Diagnostic method and device using light |
| CN102283642A (en) * | 2011-06-10 | 2011-12-21 | 中国科学院深圳先进技术研究院 | Wearable system capable of continuously measuring multiple physiological parameters based on body sensor network |
| CN103249361A (en) * | 2010-11-18 | 2013-08-14 | 美敦力公司 | Coefficent determination for blood oxygen saturation and total hemoglobin concentration indices |
| CN104146714A (en) * | 2014-08-21 | 2014-11-19 | 天津大学 | Organizer local oxyhemoglobin saturation variation topology imaging device and method |
| CN104173059A (en) * | 2014-09-04 | 2014-12-03 | 电子科技大学 | Optical non-intrusive shock monitor and detection method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1444906A (en) * | 2002-03-16 | 2003-10-01 | 三星电子株式会社 | Diagnostic method and device using light |
| CN103249361A (en) * | 2010-11-18 | 2013-08-14 | 美敦力公司 | Coefficent determination for blood oxygen saturation and total hemoglobin concentration indices |
| CN102283642A (en) * | 2011-06-10 | 2011-12-21 | 中国科学院深圳先进技术研究院 | Wearable system capable of continuously measuring multiple physiological parameters based on body sensor network |
| CN104146714A (en) * | 2014-08-21 | 2014-11-19 | 天津大学 | Organizer local oxyhemoglobin saturation variation topology imaging device and method |
| CN104173059A (en) * | 2014-09-04 | 2014-12-03 | 电子科技大学 | Optical non-intrusive shock monitor and detection method thereof |
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