CN104707263B - Energy transmission system - Google Patents
Energy transmission system Download PDFInfo
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- CN104707263B CN104707263B CN201510013609.7A CN201510013609A CN104707263B CN 104707263 B CN104707263 B CN 104707263B CN 201510013609 A CN201510013609 A CN 201510013609A CN 104707263 B CN104707263 B CN 104707263B
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Abstract
The present invention relates to a kind of energy transmission system, including：Energy transmission applicator, the disposable interface positioned at the applicator distal end, antenna structure and cooling circuit.
Description
The application is divisional application, and the Application No. 200880126637.8 of original application, the applying date is December 12 in 2008
Day, entitled " disposable medical equipment and its system ".
Related application
This application claims entitled " the SYSTEMS AND METHODS FOR CREATING submitted on October 22nd, 2008
AN EFFECT USING MICROWAVE ENERGY TO SPECIFIED TISSUE, SUCH AS SWEAT GLANDS's "
Entire contents, are incorporated herein by reference by the rights and interests that U.S. Provisional Patent Application the 61/196th, 948 herein.
The application is also entitled " the SYSTEMS AND METHODS FOR CREATING submitted on April 21st, 2008
AN EFFECT USING MICROWAVE ENERGY TO SPECIFIED TISSUE " Copending U.S. Patent Application No.
The part continuation application of 12/107, No. 025, the Copending U.S. Patent Application requires the title submitted on April 19th, 2007
For " METHODS AND APPARATUS FOR REDUCING SWEAT PRODUCTION " U.S. Provisional Patent Application
No. 60/912,899, entitled " METHODS, DEVICES AND SYSTEMS the FOR NON- that submit on December 12nd, 2007
INVASIVE DELIVERY OF MICROWAVE THERAPY " U.S. Provisional Patent Application the 61/013,274th and
Entitled " the SYSTEMS AND METHODS FOR CREATING AN EFFECT USING submitted on April 17th, 2008
The rights and interests of MICROWAVE ENERGY IN SPECIFIED TISSUE " U.S. Provisional Patent Application the 61/045,937th.
The full content of all above-mentioned priority applications is specifically incorporated herein as reference herein.
Copending U.S. Patent Application No. 12/107,025 also requires that submitted April 18 for 2008 entitled
" METHODS AND APPARATUS FOR SWEAT PRODUCTION " PCT application the PCT/US08/60935th, 2008
Entitled " METHODS, DEVICES, AND SYSTEMS FOR the NON-INVASIVE DELIVERY that on April 18, in submits
It is entitled that OF MICROWAVE THERAPY " PCT application was submitted April 18 for No. PCT/US08/60929 and 2008
“SYSTEMS AND METHODS FOR CREATING AN EFFECT USING MICROWAVE ENERGY TO
It is entitled that SPECIFIED TISSUE " PCT application was submitted April 18 for No. PCT/US08/60940 and 2008
“SYSTEMS AND METHODS FOR CREATING AN EFFECT USING MICROWAVE ENERGY TO
The priority of SPECIFIED TISSUE " PCT application the PCT/US08/60922nd.All above-mentioned priority applications herein
Full content is specifically incorporated herein as reference.
Technical field
The application is related to the method, apparatus and system of noninvasive microwave transmission treatment.Specifically, the application is related to patient's
Epidermal tissue, dermal tissue and hypodermis non-invasively transmission energy（Such as microwave energy）To realize various therapeutic effects
And/or the method, apparatus and system of aesthetic effect.
Background technology
It is well known that, the therapy based on energy, which can be applied to, to be spread all over the tissue of body to realize a variety of therapeutic effects
And/or aesthetic effect.Still need to improve the validity of these therapies based on energy and with minimum adverse side effect
Or enhanced therapeutic effect is provided in the case of discomfort.
The content of the invention
The invention provides following energy transmission system：
Scheme 1：A kind of energy transmission system, including：Energy transmission applicator；Positioned at the disposable of the applicator distal end
Interface, the disposable interface includes：Tissue cavity positioned at the distal end of the disposable interface, the tissue cavity includes being located at it
The compliant member of distal end, the compliant member is positioned at around the outward flange of tissue cavity to provide between skin and the tissue cavity
Sealing；Positioned at the applicator chamber of the near-end of the disposable interface；Connect the vacuum of the tissue cavity and the applicator chamber
Loop, the vacuum loop is connected to vacuum pressure source；The flexible membrane of tissue biological's barrier is formed, tissue biological's barrier will
The tissue cavity and the applicator chamber separate, and tissue biological's barrier is the dielectric material of microwaves energy；Formed
The film filter of applicator biological barrier, the applicator biological barrier is located between the tissue cavity and the applicator chamber
In vacuum loop, with the vacuum pressure in balanced tissue cavity and applicator chamber；And positioned at the applicator chamber near-end it is true
Empty seal, when applicator is located in the applicator chamber, the vacuum seal is oriented to seal the applicator chamber；
Antenna structure, it includes being configured at least one antenna hole that energy is propagated by the distal end of the applicator, with
And the cooling circuit including coldplate, wherein at least a portion of the cooling circuit is placed in the antenna and the applicator
The distal end between.
Scheme 2：Energy transmission system according to scheme 1, wherein the antenna includes：Multiple antennas；It is configured to
To the distribution member of energy described in the multiple antenna propagation.
Energy transmission system of the scheme 3. according to scheme 2, wherein the distribution member includes microwave switch.
Energy transmission system of the scheme 4. according to scheme 2, wherein the distribution member includes power divider.
Energy transmission system of the scheme 5. according to scheme 1, wherein the energy transmission applicator also includes：
Dispersing element between the hole and the distal end of the applicator.
Energy transmission system of the scheme 6. according to scheme 1, wherein the cooling circuit also includes：
Cooling chamber between the antenna hole and the proximal lateral of the coldplate.
Energy transmission system of the scheme 7. according to scheme 1, wherein the antenna structure includes waveguide assemblies, it is described
Waveguide assemblies include being configured to multiple antenna holes that energy is propagated by the distal end of the applicator.
Energy transmission system of the scheme 8. according to scheme 7, wherein the waveguide assemblies include：
Multiple radiating guides in antenna holder；
It is configured to the distribution member to energy described in the multiple antenna propagation.
Energy transmission system of the scheme 9. according to scheme 8, wherein the distribution member includes microwave switch.
Energy transmission system of the scheme 10. according to scheme 8, wherein the distribution member includes power divider.
Energy transmission system of the scheme 11. according to scheme 7, wherein the energy transmission applicator also includes：
Multiple dispersing elements between the hole and the distal end of the applicator.
Energy transmission system of the scheme 12. according to scheme 7, wherein the cooling circuit also includes being located at the day
Cooling chamber between the proximal lateral of string holes gap and the coldplate.
Energy transmission system of the scheme 13. according to scheme 12, wherein the waveguide assemblies include：
Multiple radiating guides in antenna holder；
It is configured to the distribution member to energy described in the multiple antenna propagation.
Energy transmission system of the scheme 14. according to scheme 13, wherein the cooling circuit is additionally included in the antenna
Cooling channel in support, the cooling channel is connected to the cooling chamber.
Energy transmission system of the scheme 15. according to scheme 7, wherein the coldplate includes：
Proximal end face；
Distal surface；
One or more thermocouple grooves in the distal surface；And
One or more thermocouples in the thermocouple groove.
Energy transmission system of the scheme 16. according to scheme 15, wherein the thermocouple groove is disposed parallel to
The E- fields launched when the energy of the propagation is microwave energy by the waveguide assemblies.
Energy transmission system of the scheme 17. according to scheme 16, wherein the microwave energy is passed with TE10 patterns
Broadcast.
Brief description of the drawings
With reference to accompanying drawing, the present invention is appreciated that from the following detailed description of preferred embodiment, wherein：
Fig. 1 is according to an embodiment of the present including generator, applicator and disposable device
（disposable）System diagram.
Fig. 2 is the stereogram of applicator according to an embodiment of the present and disposable device.
Fig. 3 is the end-view of the distal end of applicator shown in Fig. 2 and disposable device.
Fig. 4 is the exploded perspective view of applicator shown in Fig. 2 and disposable device.
Fig. 5 is the stereogram of disposable device according to an embodiment of the present.
Fig. 6 is the sectional view of the E-E interceptions of the disposable device shown in Fig. 5.
Fig. 7 is the stereogram of antenna holder according to an embodiment of the present.
Fig. 8 is the sectional view of the K-K interceptions of the antenna holder shown in Fig. 7.
Fig. 9 is the stereogram of aerial array according to an embodiment of the present and disposable device.
Figure 10 is the sectional view of the A-A interceptions of the aerial array and disposable device shown in Fig. 9.
Figure 11 is the sectional view of the B-B interceptions of the aerial array and disposable device shown in Fig. 9.
Figure 12 is the stereogram of aerial array according to an embodiment of the present.
Figure 13 is the sectional view of the C-C interceptions of the aerial array shown in Figure 12.
Figure 14 is the sectional view of the D-D interceptions of the aerial array shown in Figure 12.
Figure 15 is the sectional view of the C-C interceptions of the distal portions of the aerial array shown in Figure 12.
Figure 16 shows coldplate and thermocouple according to an embodiment of the present.
Figure 17 is the sectional view of the J-J interceptions of a part for coldplate shown in Figure 16 and thermocouple.
Figure 18 is the sectional view of the J-J interceptions of a part for coldplate shown in Figure 16 and thermocouple.
Figure 19 is the vertical of aerial array according to an embodiment of the present, coolant cavity, separation rib and dispersing element
Body end view.
Figure 20 is the end-view of aerial array shown in Figure 19, coolant cavity, separation rib and dispersing element.
Figure 21 is the stereogram of applicator according to an embodiment of the present and disposable device.
Figure 22 is the end-view of the distal end of applicator shown in Figure 21 and disposable device.
Figure 23 is the exploded perspective view of the applicator shown in Figure 21.
Figure 24 is the sectional view of the applicator shown in Figure 21.
Figure 25 is the view of the distal end of disposable device according to an embodiment of the present.
Figure 26 is the view of the proximal lateral of the disposable device shown in Figure 25.
Figure 27 is the view of the first paragraph of the proximal lateral of the disposable device shown in Figure 26.
Figure 28 is the view of the second segment of the proximal lateral of the disposable device shown in Figure 26.
Figure 29 is the sectional view of the H-H interceptions of the disposable device shown in Figure 25.
Figure 30 is one section of view of the disposable device shown in Figure 29.
Figure 30 A be according to the present invention alternate embodiments figure 29 illustrates disposable device one section of view.
Figure 30 B be according to the present invention alternate embodiments figure 29 illustrates disposable device one section of view.
Figure 31 is the stereogram of antenna holder according to an embodiment of the present.
Figure 32 is the three-dimensional cutaway view of the F-F interceptions of the antenna holder shown in Figure 31.
Figure 33 is the sectional view of the F-F interceptions of the antenna holder shown in Figure 31.
Figure 34 is the three-dimensional cutaway view of one section of the I-I interceptions of the antenna holder shown in Figure 31.
Figure 35 is the stereogram of aerial array according to an embodiment of the present.
Figure 36 is the sectional view of the I-I interceptions of the aerial array shown in Figure 35.
Figure 37 is the view of the first paragraph of the sectional view of the aerial array shown in Figure 36.
Figure 38 is the stereogram of the second segment of the sectional view of the aerial array shown in Figure 36.
Figure 39 is the 3rd section of view of the sectional view of the aerial array shown in Figure 36.
Figure 40 is the end-view without the aerial array shown in Figure 35 of coldplate.
Figure 41 is the stereogram of waveguide assemblies according to an embodiment of the present.
Figure 42 is the side view of the waveguide assemblies shown in Figure 41.
Figure 43 is the sectional view of the G-G interceptions of the waveguide assemblies shown in Figure 41.
Figure 44 is one section of view of the sectional view of the waveguide assemblies shown in Figure 43.
Figure 45 is the side view of the alternate embodiments of waveguide assemblies according to an embodiment of the present.
Figure 46 is the sectional view of the waveguide assemblies shown in Figure 45.
Figure 47 is the schematic diagram of system according to an embodiment of the present.
Figure 48 is the schematic diagram of microwave links according to an embodiment of the present.
Figure 49 is the schematic diagram of controller according to an embodiment of the present.
Figure 50 is the schematic diagram of rear board according to an embodiment of the present.
Figure 51 is the schematic diagram of front panel according to an embodiment of the present.
Figure 52 is the schematic diagram of vacuum source according to an embodiment of the present.
Figure 53 is the schematic diagram of Controller Circuit Used in Microwave Power Amplifier according to an embodiment of the present.
Figure 54-58 is the schematic diagram of patient's location equipment according to an embodiment of the present.
Figure 59 is the schematic diagram for the treatment of model according to an embodiment of the present.
Figure 60 is the simple sectional view of the medical treatment device for engaging tissue according to an embodiment of the present.
Figure 61 shows the tissue contours and simplification figure of medical treatment device according to an embodiment of the present.
Figure 62 shows the tissue contours and simplification figure of medical treatment device according to an embodiment of the present.
Figure 63 shows the tissue contours and simplification figure of medical treatment device according to an embodiment of the present.
Figure 64 shows the tissue contours and simplification figure of medical treatment device according to an embodiment of the present.
Embodiment
It is accurate to although present disclosure is specific and enables those skilled in the art to implement the present invention, but it is public here
The tangible embodiment opened is only used for exemplifying the present invention and the present invention may be implemented as other specific structures.Although having been described above
Preferred embodiment, but in the case of the present invention limited without departing substantially from claim, details can be modified.
Fig. 1 is the diagram of system 2309 according to an embodiment of the present, the system 2309 include generator 2301,
Applicator 2320（Reusable part can also be referred to as）And disposable device 2363.A kind of according to the present invention implements
Example, generator 2301 will be run in 5.775 to 5.825 GHz ISM bandwidth.According to an embodiment of the present, occur
Device 2301 includes circuit to set and control power output；Measurement is positive to alarm with reverse power and setting.According to this hair
A kind of bright embodiment, generator 2301 can have the frequency centered on 5.8 GHz.A kind of according to the present invention implements
Example, generator 2301 can have the power output between 40 to 100 watts when 50 ohm loads are measured.According to the present invention
A kind of embodiment, generator 2301 can have positive/negative 3 watts of power accuracy.According to an embodiment of the present, one
Secondary property device 2363 and applicator 2320 can be formed separable two units.According to an embodiment of the present,
Disposable device 2363 and applicator 2320 can be formed individual unit.According to an embodiment of the present, combination is worked as
When together, disposable device 2363 and applicator 2320 can form medical treatment device 2300.A kind of according to the present invention implements
Example, generator 2301 can be microwave generator.According to an embodiment of the present, can be that disposable device 2363 is organized
Head.According to an embodiment of the present, in system 2309, applicator 2320 can be connected to hair by applicator cable 2334
Raw device 2301.According to an embodiment of the present, in system 2309, applicator cable 2334 can include coolant conduit
2324th, energy cable 2322, cooling agent thermocouple electric wire 2331, coldplate thermocouple electric wire 2330 and duplexer signal
2481.According to an embodiment of the present, in system 2309, coolant conduit 2324 may be connected to coolant source
2310（The coolant source 2310 can be the Nanotherm works with 8 psi pumps that can be for example obtained from ThermoTek, Inc
Industry recycle cooler）.According to an embodiment of the present, in system 2309, energy cable 2322 can be defeated by microwave
Go out connector 2443 and be connected to generator 2301.According to an embodiment of the present, in system 2309, duplexer signal
2481 can be connected to generator 2301 by duplexer connector 2480.According to an embodiment of the present, in system
In 2309, disposable device 2363 can be connected to generator 2301 by vacuum tube 2319, and the vacuum tube 2319 can include example
The generator biological barrier 2317 of hydrophobic filter in this way.According to an embodiment of the present, in system 2309, vacuum tube
2319 can be connected to generator 2301 by vacuum ports connector 2484.According to an embodiment of the present, in system
In 2309, the front panel 2305 of generator 2301 can include power control knob 2454, vacuum control knob 2456, day line selection
Select switch 2462（Display element and selecting switch can be included）, vacuum meter measuring device 2486, antenna temperature display 2458, cooling
Agent temperature indicator 2460, precooling timer 2468（Display element and time setting element can be included）, energy timer
2470（Display element and time setting element can be included）And rear cooling timer 2472（Can include display element and when
Between set element）.According to an embodiment of the present, if power control knob of the measurement signal on front panel 2305
2454 setting request power specifications, then error signal be sent to the controller 2302 of generator 2301.According to the present invention
A kind of embodiment, if the reverse power of measurement is more than the preset limit to the reverse power of measurement, error signal is sent out
It is sent to controller 2302.According to an embodiment of the present, if the reverse power of measurement is more than approximate 25 watts,
Error signal is sent to controller 2302.According to an embodiment of the present, vacuum tube 2319 can include flexible vacuum
Flexible pipe 2329 and generator biological barrier 2317.According to an embodiment of the present, flexible vacuum hose 2329 is suitable to collect
It may spill that the fluid of generator 2301, such as sweat or blood will not be reached from disposable device 2363.According to the present invention
A kind of embodiment, generator biological barrier 2317 can include hydrophobic filter come prevent fluid enter generator 2301 it is true
Empty port connector 2484.According to an embodiment of the present, generator biological barrier 2317 can include hydrophobic filter,
The Millex FH filters being made up of 0.45 micron hydrophobic PTFE that can be for example obtained from Milipore.According to the one of the present invention
Embodiment is planted, generator biological barrier 2317 can be located in flexible hose.According to an embodiment of the present, applicator cable
Generator 2301 can be connected to applicator 2320 by line 2334.According to an embodiment of the present, applicator cable 2334
Coolant conduit 2324, energy cable 2322, duplexer signal 2481, coldplate thermocouple electric wire 2330 and cold can be included
But agent thermocouple electric wire 2331.According to an embodiment of the present, applicator cable 2334 can also include thermocouple arrays
Cable.According to an embodiment of the present, cooling fluid can be transported to by coolant conduit 2324 from coolant source 2310
Applicator 2320.According to an embodiment of the present, microwave switch selection data can be transported to by applicator cable 2334
Applicator 2320 and temperature data is transported to generator 2301 from the thermocouple in applicator 2320.According to the one of the present invention
Embodiment is planted, applicator cable 2334 can include one or more single cables and connector.According to the one of the present invention
Embodiment is planted, generator connector can be designed to and suitable for applicator cable 2334 is connected into generator 2301, wrap
Include the connection for cooling fluid duct, duplexer control, thermocouple and main microwave connector.
Fig. 2 is the stereogram of applicator 2320 according to an embodiment of the present and disposable device 2363.According to
A kind of embodiment of the present invention, applicator 2320 can be latched mechanism 2365 and be attached to disposable device 2363.According to this hair
A kind of bright embodiment, applicator 2320 can include applicator cable 2334.According to an embodiment of the present, disposably
Device 2363 can include vacuum tube 2319, tissue cavity 2338 and tissue boundary surface 2336.A kind of according to the present invention implements
Example, tissue cavity 2338 can be that destination organization can be positioned to the hole of emphasis treatment.According to an embodiment of the present,
Tissue boundary surface 2336 can include tissue biological's barrier 2337, vacuum ports 2342 and vacuum passage 2350.According to this hair
A kind of bright embodiment, vacuum ports 2342 can be located at around the outward flange on tissue boundary surface 2336.According to the present invention's
A kind of embodiment, vacuum ports 2342 can be configured to substantially equidistant each other.According to an embodiment of the present, vacuum end
Mouth 2342 can be averaged setting around interface surface.According to an embodiment of the present, vacuum ports 2342 can be surrounded
Tissue biological's barrier.According to an embodiment of the present, vacuum ports 2342 can be positioned in away from the pre- spacing of cavity wall 2354
From place.According to an embodiment of the present, vacuum ports 2342 can have completely open region and be oriented to be enough
Obtain and keep the tissue in tissue cavity 2338.According to an embodiment of the present, vacuum ports 2342 can surround tissue
Chamber 2338 is evenly distributed to help equally to obtain tissue across tissue cavity 2338.According to an embodiment of the present,
Vacuum ports 2342 can be symmetrical to help symmetrically to obtain tissue around tissue cavity 2338.According to the one of the present invention
Embodiment is planted, can for example there are approximate 28 vacuum ports 2342 in tissue boundary surface 2336.According to one kind of the present invention
Embodiment, vacuum ports 2342 can contact vacuum passage 2350.According to an embodiment of the present, vacuum ports 2342 will
Tissue cavity 2338 is connected to vacuum loop 2341.According to an embodiment of the present, vacuum passage 2350 can be positioned so that
Contacted around tissue biological's barrier 2337 with least one flowing in vacuum ports 2342.A kind of according to the present invention implements
Example, the auxiliary of vacuum passage 2350 holding tissue is in place when applying the vacuum pressure.According to an embodiment of the present, vacuum is led to
Road 2350 aids in producing suction sign on patient skin（This suction sign can be referred to as impression sign）.According to the present invention
A kind of embodiment, doctor or user can use suction sign to recognize the region being treated.According to the present invention's
A kind of embodiment, the laser or other light sources being integrated in disposable device 2363 can be used to be applied to group in applicator
There is provided guiding to indicate area for treatment for user before knitting.According to an embodiment of the present, vacuum loop 2341 can be with
Separate the vacuum pressure applied for example, by vacuum tube 2319 between tissue cavity 2338 and applicator chamber 2346.According to the present invention
A kind of embodiment, when fluid flows into applicator chamber 2346 from tissue cavity 2338 or forbids it to flow, vacuum loop 2341
It may be adapted to the air pressure of balanced tissue biological's barrier both sides.According to an embodiment of the present, tissue boundary surface
Vacuum passage 2350 in 2336 can aid in keeping tissue during treating and prevent tissue from tissue boundary surface 2336
Peel off.According to an embodiment of the present, the vacuum sound in tissue cavity 2338 can provide correct acquisition group for user
The sound instruction knitted.According to an embodiment of the present, as long as user can hear vacuum sound, then organize not by just
Really it is positioned in tissue cavity 2338.
Fig. 3 is the end-view of the distal end of the applicator 2320 and disposable device 2363 shown in Fig. 2.According to the present invention's
A kind of embodiment, disposable device 2363 can include for example can be flexible membrane tissue biological's barrier 2337.According to this hair
A kind of bright embodiment, disposable device 2363 can include for example can be polyethylene film tissue biological's barrier 2337.Root
According to a kind of embodiment of the present invention, applicator 2320 can include for example being to be located at the coldplate behind biological barrier 2337
2340.According to an embodiment of the present, disposable device 2363 can include vacuum ports 2342 and vacuum passage 2350.
According to an embodiment of the present, vacuum ports 2342 can be for example in the distal end of disposable device 2363 can with it is true
The hole of blank pipe 2319 and the direct or indirect connection of vacuum passage 2350, it can be formed by the groove in disposable device 2363.
According to an embodiment of the present, disposable device 2363 can include chamber opening 2339.A kind of according to the present invention implements
Example, chamber opening 2339 can be ellipse.According to an embodiment of the present, chamber opening 2339 can be approximate 35 mm wide
It is × 50 millimeters long.According to an embodiment of the present, tissue cavity 2338 can approximate 7 millimeters deep.
According to an embodiment of the present, tissue biological's barrier 2337 can be positioned so that when disposable device 2363 is attached
Sealing is provided when being connected in applicator 2320.According to an embodiment of the present, tissue biological's barrier 2337 may be adapted to prevent
Any bioresorbable on skin and skin includes the applicator 2320 of coldplate 2340.According to an embodiment of the present,
Tissue biological's barrier 2337 can be positioned so that extends across coldplate when disposable device 2363 is attached to applicator 2320
2340.According to an embodiment of the present, tissue biological's barrier 2337 is designed to minimize the cold of combination at least in part
The conductive heat loss of the sub-assembly of 2340/ tissue biological's barriers of Que Ban 2337.According to an embodiment of the present, tissue biological's barrier
2337 can be the flexible membrane with approximate 0.0005 inch thickness and can be at approximate 0.0001 inch to approximate 0.030 English
Change between very little.According to an embodiment of the present, tissue biological's barrier 2337 can be with impermeable fluid and substantially not permeable
Air permeable.According to an embodiment of the present, tissue biological's barrier 2337 can be can substantially transmissive microwave energy dielectric
Material.According to an embodiment of the present, tissue biological's barrier 2337 can not disturbed through tissue biological's barrier 2337
Microwave field material.According to an embodiment of the present, tissue biological's barrier 2337 can be low-loss material.According to this
A kind of embodiment of invention, tissue biological's barrier 2337 can have dielectric constant between 2 to 15 and preferably 3 to
Dielectric constant between 3.5.According to an embodiment of the present, tissue biological's barrier 2337 can have approximate 0.1
GPa is to the Young's modulus between approximate 5 GPa.According to an embodiment of the present, tissue biological's barrier 2337 can have
Approximate 0.1 to the Young's modulus between approximate 3.1 GPa.According to an embodiment of the present, tissue biological's barrier 2337
There can be the Young's modulus between approximate 0.1 to 1.5 GPa.According to an embodiment of the present, tissue biological's barrier
2337 can be the flexible membrane of such as polyethylene or PET that can form all or part of tissue boundary surface 2336.According to this
A kind of embodiment of invention, tissue biological's barrier 2337 can have approximate 1W/ (mK) to approximate 100 W/ at room temperature
(m·K) （TS）Between high-termal conductivity rigid solid ceramic material.In alternative embodiments, tissue biological's barrier 2337
Can be that there is approximate 1W/ (mK) at room temperature to approximate 100 W/ (mK)（TS）Between high-termal conductivity it is hard solid
Body ceramic material.According to an embodiment of the present, hard tissue biological's barrier 2337 can be eliminated for applicator
In 2320 the need for vacuum loop 2341.According to an embodiment of the present, solid ceramic tissue biological barrier 2337 can be with
Microwave permittivity with selection for 5.8 GHz.According to an embodiment of the present, hard tissue biological's barrier
2337 can be by the dielectric constant with matching or approximate match coldplate 2340（Such as approximate 10 dielectric constant）Dielectric
The material of constant is constituted.According to an embodiment of the present, it is adaptable to which the material of hard tissue biological's barrier can include
The material of dielectric constant with the value between 1 to 80, and if the thickness of tissue biological's barrier 2337 is minimized to foot
The microwave transparent of tissue biological's barrier 2337 is not interfered with the change for ensuring dielectric constant, then is also acceptable.According to
A kind of embodiment of the present invention, tissue biological's barrier 2337 can have the thickness less than approximate 0.001 inch to maximize
Microwave transparent.According to an embodiment of the present, hard tissue biological's barrier 2337 can be by with not increasing cooling
The material of the dielectric constant of additional dielectric discontinuity between plate 2340 and the tissue being bonded in tissue cavity 2338 is constituted.Root
According to a kind of embodiment of the present invention, hard tissue biological's barrier 2337 can be selected to minimize coldplate biological barrier group
The overall effective thickness of component.According to an embodiment of the present, the combination of coldplate 2340 and tissue biological's barrier 2337
Thickness can be selected to minimize the peak value SAR of coldplate 2340 itself reduction.According to an embodiment of the present, it is cold
But the combination thickness of plate 2340 and tissue biological's barrier 2337 can be selected to be less than 0.018 inch to minimize coldplate
The 2340 peak value SAR of itself reduction.According to an embodiment of the present, coldplate 2340 and tissue biological's barrier 2337
Combination thickness can be selected to be less than 0.020 inch so as to the peak value SAR that minimizes coldplate 2340 itself reduction.
Fig. 4 is the exploded perspective view of applicator 2320 shown in Fig. 2 and disposable device 2363.It is real according to one kind of the present invention
Example is applied, applicator 2320 can include coldplate 2340, and the coldplate 2340 can include being attached to coldplate thermocouple electric wire
2330 one or more thermocouples.According to an embodiment of the present, applicator 2320 may include separation rib 2393, day
Line bracket 2374, cooling agent supply pipe 2312, cooling agent recurrent canal 2313, radiating guide 2364 (a-d), the and of duplexer 2357
Applicator cable 2334.According to an embodiment of the present, applicator cable 2334 can include duplexer signal 2481,
Energy cable 2322 and coolant conduit 2324.According to an embodiment of the present, applicator cable 2334 can include cold
But plate thermocouple electric wire 2330 and cooling agent thermocouple electric wire 2331.According to an embodiment of the present, disposable device
2363 can include vacuum tube 2319.According to an embodiment of the present, energy cable 2322（Microwave cable can be referred to as
Line）Microwave energy is sent to applicator 2320 from generator 2301.According to an embodiment of the present, energy cable 2322
The duplexer 2357 transferred microwave energy into applicator 2320（Microwave switch can be referred to as）.According to the one of the present invention
Embodiment is planted, energy cable 2322 can be designed to the output of frequency matched generator 2301 interested and applicator
2320.According to an embodiment of the present, energy cable 2322 can be designed to 5.8 GHz matched generators 2301
Output and applicator 2320.According to an embodiment of the present, energy cable 2322 can have small under 50 ohm loads
In 2dB consume.According to an embodiment of the present, energy cable 2322 can be with six feet consumed less than 2dB
Coaxial cable.According to an embodiment of the present, energy cable 2322 can be flexible cable to maximize applicator cable
The overall flexibility of line 2334.According to an embodiment of the present, the radiating guide 2364 led in aerial array 2355 it is mutual
Even cable 2372 is preferably balanced and is matched so that the output of each radiating guide 2364 is respectively provided with equal-wattage.According to this
A kind of embodiment of invention, the interconnecting cable 2372 of the radiating guide 2364 led in aerial array 2355 is preferably balanced simultaneously
Be matched with will pass through select appropriate length and type of cable with so that the output of each radiating guide 2364 be respectively provided with it is identical
Power is so that it is guaranteed that Differential Output between radiating guide 2364 and applicator 2320.According to an embodiment of the present, lead to
It is the coaxial cable of low-loss to the interconnecting cable 2372 of radiating guide 2364.According to an embodiment of the present, ripple is led to
The interconnecting cable 2372 of lead antenna 2364 has the consume less than 1dB.According to an embodiment of the present, regulation can be passed through
Generator power output or energy transmission time compensate the change of matching.According to an embodiment of the present, antenna holder
2374 can include thermocouple guide hole（It is not shown）, it can be sealed so that permission thermocouple electric wire through disposable device
So as to prevent vacuum leak in vacuum seal between 2363 and applicator 2320.According to an embodiment of the present, day
Line bracket 2374 includes Support Channel 2389, and cooling fluid flows through the Support Channel 2389 as portion cooling agent loop.According to
The present invention a kind of embodiment, alternative antenna can include electromagnetic horn, many dielectric filler radiating guides, slot antenna,
Microstrip antenna, paster antenna and Vivaldi antennas.According to an embodiment of the present, duplexer 2357 may be adapted to connect
Microwave signal and control signal from generator are received, and based on the control signal received come in aerial array 2355
Microwave signal is changed between radiating guide 2364.According to an embodiment of the present, duplexer 2357 can be electromechanical same
Axle microwave relay, for example, can obtain from RealComm Technologies.According to an embodiment of the present, can be with
Via antenna selection switch, for example, opened as the day line options of a part for the antenna selection switch 2462 on generator 2301
Close, come（For example sequentially）Start one or more antennas in applicator 2320.According to an embodiment of the present, day
Wiretap 2357（Distribution member can be referred to as）It may be adapted to the segmentation between radiating guide 2364 and come from energy cable 2322
Power come be simultaneously two or more radiating guides 2364 provide power.According to an embodiment of the present, antenna is opened
Closing 2357 can be adapted for while splitting the power divider of the microwave energy between one or more radiating guides 2364.Root
According to a kind of embodiment of the present invention, energy cable 2322 transfers microwave energy into duplexer 2357.According to the one of the present invention
Embodiment is planted, microwave power is transported to each radiating guide 2364 by feeder cable from duplexer 2357.According to the present invention's
A kind of embodiment, the cable for conveying microwave energy can be flexible low-loss cable.According to an embodiment of the present,
Can have 0 under frequency-of-interest to the consume between 2dB for conveying the cable of microwave energy.According to one kind of the present invention
Embodiment, can have 0 to the consume between 2dB for conveying the cable of microwave energy at approximate 5.8 GHz frequency.Root
According to a kind of embodiment of the present invention, there can be approximate 50 ohm of impedance for conveying the cable of microwave energy.
Fig. 5 is the stereogram of disposable device 2363 according to an embodiment of the present.According to one kind of the present invention
Embodiment, disposable device 2363 can include tissue biological's barrier 2337, applicator vacuum ports 2327 and be also referred to as
The applicator chamber 2346 of reusable chamber.According to an embodiment of the present, applicator chamber 2346 may be adapted to receive bag
Include the distal end of the applicator 2320 of coldplate 2340.According to an embodiment of the present, disposable device 2363 can include
Applicator interface（Interface）2344（Reusable interface can also be referred to as）.According to an embodiment of the present, discharge
Device interface 2344 includes applicator chamber 2346, vacuum seal 2348, present a theatrical performance as the last item on a programme 2325 and latch component 2359.According to the present invention's
A kind of embodiment, applicator chamber 2346 may be adapted to receive the distal end of applicator 2320 and contribute to the distal end of applicator 2320
Engagement between tissue biological's barrier 2337.According to an embodiment of the present, vacuum seal 2348 can be packing ring,
The packing ring can be disposed about the outside of applicator chamber 2346, and may be adapted to engage the distal end of applicator 2320 so as to
Applicator chamber 2346 is sealed when disposable device 2363 is attached to applicator 2320 and vacuum leak is prevented.According to the present invention
A kind of embodiment, when engaged, vacuum seal 2348 can be by compression approximate 20 to approximate 5 percent percent
Between ten, to ensure good vacuum sealing and prevent vacuum leak.According to an embodiment of the present, vacuum seal
2348 can be compressed one section of distance for being enough to ensure that good vacuum sealing and prevent leakage.A kind of according to the present invention implements
Example, presenting a theatrical performance as the last item on a programme 2325 can be disposed about at least a portion of applicator chamber 2346.According to an embodiment of the present, press
Platform 2325 can be set and be positioned to prevent that vacuum seal from being pressed when disposable device 2363 is attached to applicator 2320
Contracting exceedes predetermined point.According to an embodiment of the present, present a theatrical performance as the last item on a programme 2325 can be set and be positioned to work as disposable device
2363 are attached to prevent vacuum seal to be compressed beyond 20 percent during applicator 2320.A kind of according to the present invention implements
Example, presenting a theatrical performance as the last item on a programme 2325 can be set and be positioned to prevent vacuum seal when disposable device 2363 is attached to applicator 2320
It is compressed beyond 50 percent.According to an embodiment of the present, latch component 2359 may be adapted to contribute to disposable
Engagement between device 2363 and applicator 2320.According to an embodiment of the present, the breech lock on disposable device 2363
Element 2359 can be adapted for the latch holder for engaging the breech lock in applicator 2320.
Fig. 6 is the sectional view of the disposable device 2363 along Fig. 5 E-E interceptions.According to an embodiment of the present, one
Secondary property device 2363 includes tissue boundary surface 2336, tissue cavity 2338, tissue biological's barrier 2337, applicator chamber 2346, chamber
Wall 2354 and vacuum ports 2342.According to an embodiment of the present, vacuum ports 2342 can be connected to vacuum loop
2341, the vacuum loop 2341 can be connected to applicator chamber 2346 and by vacuum coupling by applicator vacuum ports 2327
2328 are connected to vacuum pressure source（It is not shown）.According to an embodiment of the present, cavity wall 2354 can be transparent or semi-transparent
It is bright to allow doctor or other users to see in tissue cavity 2338 and to confirm that tissue obtains situation.
According to an embodiment of the present, cavity wall 2354 can form approximate 5 to 20 degree with tissue boundary surface 2336
Between angle.According to an embodiment of the present, cavity wall 2354 can form approximate 20 degree with tissue boundary surface 2336
Angle.According to an embodiment of the present, cavity wall 2354 can be formed by hard makrolon or plastic material.According to this hair
A kind of bright embodiment, cavity wall 2354 can be coated with lubricant（E.g. silicone oil, Teflon, Parylene or other appropriate paintings
Layer material）Thin layer, in order to obtain tissue.According to an embodiment of the present, tissue boundary surface 2336 can be coated
There is lubricant（E.g. silicone oil, Teflon, Parylene or other appropriate coating materials）Thin layer, in order to obtain tissue.Root
According to a kind of embodiment of the present invention, tissue cavity 2338 is applied to（Including wave guide wall 2366 and tissue boundary surface 2336）Example
Face coat such as silicone oil, Teflon, Parylene or other appropriate coating materials helps easily to obtain tissue and obtained
Prevent tissue from moving when taking the tissue.According to an embodiment of the present, wave guide wall 2366 can by short at one end or by
The waveguide of the direct plating of dielectric fill material is constituted.According to an embodiment of the present, the thickness of wave guide wall 2366 can be with
It is at least 5 times of the conductive skin depth for the material for constituting wave guide wall 2366.According to an embodiment of the present, wave guide wall
2366 can be copper-plated dielectric filler 2368.According to an embodiment of the present, the thickness of wave guide wall 2366 can be
There is between approximate 0.0002 inch to 0.040 inch and preferably approximate 0.003 inch of thickness.According to the one of the present invention
Embodiment is planted, wave guide wall 2366 can be formed by solid conduction material.According to an embodiment of the present, wave guide wall 2366 can be with
Formed by waveguide, the waveguide is cut into predetermined length and is equipped with conduction in the side relative with radiating guide hole
Short-circuit part.According to an embodiment of the present, radiating guide 2364 can have approximate 0.62 inch × 0.31 inch of hole
Gap.According to an embodiment of the present, dielectric filler 2368 can have the dielectric constant for being selected to 5.8 GHz.According to
A kind of embodiment of the present invention, the temperature measured at coldplate thermocouple 2395 can indicate that in tissue biological's barrier 2337
Temperature of the lower section adjacent to the skin surface of coldplate thermocouple 2395.According to an embodiment of the present, dielectric filler can
With the dielectric constant with approximate 10.According to an embodiment of the present, dielectric filler 2368 should be low-loss material.
According to an embodiment of the present, the length of dielectric filler 2368 can be approximate between 20 to 80 millimeters, and preferably
Ground is approximately the integral multiple of the half of a waveguide wavelength under frequency-of-interest.According to an embodiment of the present, it is situated between
The length of electric filler 2368 can be approximate between 20 to 80 millimeters, and is approximate preferably for shortwave lead antenna 2364
28.5 millimeters and be approximate 48 millimeters for long radiating guide 2364.According to an embodiment of the present, in longer waveguide day
The dielectric length that the length of dielectric filler 2368 in line 2364 can compare in shortwave lead antenna 2364 is one or more
Waveguide wavelength.According to an embodiment of the present, the length of the dielectric filler 2368 in longer antenna can compare short day
Dielectric filler 2368 in line grows approximate 20 millimeters.
Fig. 7 is the stereogram of antenna holder 2374 according to an embodiment of the present, and antenna holder 2374 also can quilt
Referred to as waveguide keeper.According to an embodiment of the present, antenna holder 2374 includes Support Channel 2389 and antenna cavity
2377。
Fig. 8 is the sectional view of the antenna holder 2374 along Fig. 7 K-K interceptions.According to an embodiment of the present, antenna
Support 2374 includes antenna cavity 2377 and support loop 2385.According to an embodiment of the present, support loop 2385 includes
Support Channel 2389 and coolant cavity 2360.According to an embodiment of the present, support loop 2385 can be used for transmission it is cold
But fluid passes through antenna holder.According to an embodiment of the present, Support Channel 2389 can be connected in parallel, so as to allow cooling
Fluid flows through each Support Channel 2389 and coolant cavity 2360 in support loop 2385 parallel.According to one kind of the present invention
Embodiment, Support Channel 2389 can be connected in series for example, by refrigerant distribution pipe 2314（It is illustrated in Fig. 4）So as to permit
Perhaps cooling fluid sequentially flows through each Support Channel 2389 and coolant cavity 2360 in support loop 2385.
Fig. 9 is the stereogram of aerial array 2355 according to an embodiment of the present and disposable device 2363.Root
According to a kind of embodiment of the present invention, aerial array 2355 can include antenna holder 2374 and waveguide assemblies 2358.According to this hair
A kind of bright embodiment, antenna holder 2374 can include Support Channel 2389.According to an embodiment of the present, waveguide group
Part 2358 can be positioned in the antenna cavity 2377 of antenna holder 2374 to form aerial array 2355.According to the one of the present invention
Embodiment is planted, waveguide assemblies 2358 can include one or more radiating guides 2364.According to an embodiment of the present,
Waveguide assemblies 2358 can include first wave guide antenna 2364a, second waveguide antenna 2364b, the 3rd radiating guide 2364c and the
Four radiating guide 2364d.According to an embodiment of the present, waveguide assemblies 2358 can include multiple tuned cells 2390
（It can be tuning screw）With multiple feeding connectors 2388, feeding connector 2388 can be that customization panel installs SMA connections
Device.According to an embodiment of the present, each radiating guide 2364 can include a tuned cell 2390 and a feeding
Connector 2388.According to an embodiment of the present, microwave energy can be interconnected cable 2372 and be fed to each waveguide day
Line.According to an embodiment of the present, tuned cell 2390 can include through wave guide wall 2366 and enter dielectric filler
Tuning screw in 2368, with the formation electrical contact of wave guide wall 2366.According to an embodiment of the present, tuned cell 2390 can
To be located in the rear wall away from radiating guide 2364（Such as short-circuit component 2373）At approximate 3/4 waveguide wavelength.According to this hair
A kind of bright embodiment, the depth of tuned cell 2390 can be adjusted to radiating guide 2364 being tuned to frequency-of-interest.
According to an embodiment of the present, the depth of tuned cell 2390 can be adjusted to be tuned to have by radiating guide 2364
Approximate 5.8 GHz centre frequency.
Figure 10 is the aerial array 2355 and the sectional view of disposable device 2363 along Fig. 9 A-A interceptions.According to the present invention
A kind of embodiment, waveguide assemblies 2358 are positioned in the antenna cavity 2377 of antenna holder 2374.According to one kind of the present invention
Embodiment, waveguide assemblies 2358 include one or more radiating guides 2364.According to an embodiment of the present, signal can
To be fed to by feeding connector 2388 in radiating guide 2364, feeding connector 2388 can include antenna feed device
2370.According to an embodiment of the present, radiating guide 2364 can include dielectric filler 2368, wave guide wall 2366（Can
To be, for example, waveguide or conductive wall and more specifically can be WR62 waveguides）, tuned cell 2390 and short-circuit component
2373（It can be such as metallic gasket）.According to an embodiment of the present, can be for example, by by dielectric filler 2368
Be press-fitted into the wave guide wall 2366 being made up of waveguide and across waveguide an openend brazing short-circuit component 2373
Manufacture radiating guide 2364.According to an embodiment of the present, disposable device 2363 can include tissue cavity 2338, tissue
Interface surface 2336（It can be such as tissue biological's barrier 2337）, vacuum ports 2342 and cavity wall 2354.According to the present invention's
A kind of embodiment, biological barrier 2337 can be the hydrophobic membrane that can be for example obtained from GE Osmotics.According to one kind of the present invention
Embodiment, coldplate 2340, dispersing element 2378 and separation rib 2393 can be positioned in aerial array 2355 and disposable bioreactor
In antenna cavity 2377 between part 2363.According to an embodiment of the present, dispersing element 2378（Field extension can be referred to as
Device）It can be the extension of such as dielectric filler 2368.According to an embodiment of the present, dispersing element 2378 can be with
It is such as absorber element.According to an embodiment of the present, dispersing element 2378 can be weakened at least in part from waveguide
The absorber element of the microwave energy of the hole radiation of antenna 2364.According to an embodiment of the present, dispersing element 2378 can
To be weaken from the radiation of the hole of radiating guide 2364, increase radiating guide 2364 effective field size at least in part micro-
The absorber element of wave energy.According to an embodiment of the present, dispersing element 2378 can be weakened at least in part from ripple
The absorption of hole radiation, the distribution SAR patterns in the tissue below radiating guide 2364 the microwave energy of lead antenna 2364
Element.According to an embodiment of the present, antenna feed device 2370 can extend into the dielectric filling of radiating guide 2364
The center conductor of feeding connector 2388 in thing 2368.According to an embodiment of the present, antenna feed device 2370 can be with
It is positioned such that microwave signal is delivered in radiating guide 2364 and minimized by antenna feed device from feeding connector 2388
Reaction coupling between 2370 and the rear wall of radiating guide 2364（In frequency-of-interest（Such as 5.8 GHz）Produce impedance matching
Situation）Caused reflection.According to an embodiment of the present, antenna feed device 2370 may be oriented such that microwave is believed
Number it is delivered to from feeding connector in radiating guide and minimizes the reaction coupling between feeder and rear wall（In 5.8 GHz
The match condition of 50 ohm of generation）Caused reflection.According to an embodiment of the present, antenna feed device 2370 can be by
It is positioned to away from rear 2366 approximate two millimeters of wave guide wall.According to an embodiment of the present, antenna feed device 2370 can be determined
Position is into approximate two millimeters away from the joint between short-circuit component 2373 and waveguide.
Figure 11 is the aerial array 2355 and the sectional view of disposable device 2363 along Fig. 9 B-B interceptions.According to the present invention
A kind of embodiment, radiating guide 2364 can be positioned in the antenna cavity 2377 of antenna holder 2374.According to the present invention's
A kind of embodiment, radiating guide 2364 can include dielectric filler 2368, wave guide wall 2366 and short-circuit component 2373.According to this
A kind of embodiment of invention, antenna holder 2374 can include antenna cavity 2377 and Support Channel 2389.According to the one of the present invention
Kind of embodiment, disposable device 2363 can include tissue cavity 2338, can be that the tissue of such as tissue biological's barrier 2337 is handed over
Boundary surface 2336 and cavity wall 2354.According to an embodiment of the present, dispersing element 2378, dispersing element 2378 and separation
Rib 2393 can be positioned in the antenna cavity 2377 between aerial array 2355 and disposable device 2363.
Figure 12 is the stereogram of aerial array 2355 according to an embodiment of the present.It is real according to one kind of the present invention
Apply example, waveguide assemblies 2358 can include it is multiple can be tuning screw tuned cell 2390 and multiple feeding connectors
2388.According to an embodiment of the present, microwave energy can be interconnected cable 2372 and be supplied to each radiating guide.
Figure 13 is the sectional view of the aerial array 2355 along Figure 12 C-C interceptions.According to an embodiment of the present, ripple
Guide assembly 2358 can be positioned in the antenna cavity 2377 of antenna holder 2374.According to an embodiment of the present, waveguide
Antenna 2364 can include dielectric filler 2368, wave guide wall 2366, tuned cell 2390 and can be such as metallic gasket
Short-circuit component 2373.According to an embodiment of the present, separation rib 2393, dispersing element 2378 and coldplate 2340 can be by
It is positioned at the distal end of aerial array 2355.
Figure 14 is the sectional view of the aerial array 2355 along Figure 12 D-D interceptions.According to an embodiment of the present, dissipate
The remote of aerial array 2355 and disposable device 2363 can be positioned in by penetrating element 2378, coldplate 2340 and separation rib 2393
End.
Figure 15 is the sectional view of the distal portions of the aerial array 2355 along Figure 12 C-C interceptions.According to the one of the present invention
Embodiment is planted, waveguide assemblies 2358 include one or more radiating guides 2364 (a-d).A kind of according to the present invention implements
Example, radiating guide 2364 can include dielectric filler 2368, wave guide wall 2366 and tuned cell 2390.According to the one of the present invention
Embodiment is planted, dispersing element 2378 and separation rib 2393 can be positioned in coolant cavity 2360.According to one kind of the present invention
Embodiment, coolant cavity 2360（Heat exchanger channels can also be referred to as）Cooling fluid 2361 can be included.
Figure 16 shows coldplate and thermocouple according to an embodiment of the present.A kind of according to the present invention implements
Example, coldplate thermocouple 2395 can be positioned in coldplate groove 2394.According to an embodiment of the present, coldplate
2340th, coldplate thermocouple 2395 and coldplate groove 2394 can be positioned under tissue biological's barrier 2337.
Figure 17 is the sectional view along the coldplate 2340 of Figure 16 J-J interceptions and a part for coldplate thermocouple 2395.
Figure 18 is the sectional view along the coldplate 2340 of Figure 16 J-J interceptions and a part for coldplate thermocouple 2395.According to this hair
A kind of bright embodiment, coldplate thermocouple 2395 can be flattened to ensure that tissue biological's barrier 2337 is flatted against in coldplate
2340 surface.According to an embodiment of the present, coldplate 2340 can be located at the distal end of applicator 2320.According to this hair
A kind of bright embodiment, coldplate 2340 can be bonded in the distal end of antenna holder 2374.A kind of according to the present invention implements
Example, coldplate 2340 can be positioned so that the stretch tissue biological barrier when disposable device 2363 is connected to applicator 2320
2337.According to an embodiment of the present, coldplate 2340 can be positioned so that when disposable device 2363 is attached to discharge
0.001 inch to 0.020 inch, and preferably 0.010 inch are extended in tissue cavity 2338 during device 2320.According to the present invention
A kind of embodiment, can select with approximate 0.010 inch to 0.014 inch and the preferably cooling of 0.014 inch thickness
Plate 2340.According to an embodiment of the present, increase microwave energy can be chosen to be from by rigidity, high-termal conductivity and dielectric constant
Amount in the material coupled of tissue with selecting coldplate 2340.According to an embodiment of the present, coldplate 2340 can be
Ceramics.According to an embodiment of the present, coldplate 2340 can be 90% to 99% and preferably 96% aluminum oxide.According to this
Invention a kind of embodiment, coldplate 2340 can have at room temperature approximate 1 W/ (mK) to approximate 75 W/ (mK) it
Between and preferably approximate 30 W/ (mK)（TS）Thermal conductivity factor.According to an embodiment of the present, coldplate 2340 can be with
With between 4 to 15 and preferably 10 dielectric constant.According to an embodiment of the present, coldplate 2340 can be minimum
Change with the material for the microwave energy being strapped in the form of surface wave in coldplate 2340.
According to an embodiment of the present, the distal surface of coldplate 2340 can include multiple thermocouple passages, example
Such as coldplate groove 2394.According to an embodiment of the present, coldplate groove 2394 can have at approximate 0.003 inch
Between to 0.007 inch and preferably approximate 0.005 inch of depth.According to an embodiment of the present, coldplate groove
2394 can have approximate 0.014 inch of width.According to an embodiment of the present, coldplate groove 2394 can be determined
Position into cause they under the center of the hole of radiating guide 2364 directly through.According to an embodiment of the present, it is cold
But plate groove 2394 may be oriented such that coldplate thermocouple 2395 is positioned directly at the hole of radiating guide 2364
Under center.According to an embodiment of the present, coldplate groove 2394 may be oriented such that them in dispersing element
Under 2378 center directly through.According to an embodiment of the present, coldplate groove 2394 may be oriented such that
Coldplate thermocouple 2395 is under the center of dispersing element 2378.According to an embodiment of the present, coldplate
Groove 2394 may be oriented such that them across the acquired tissue part with highest SAR.According to one kind of the present invention
Embodiment, coldplate groove 2394 may be oriented such that coldplate thermocouple 2395 is positioned in the institute with highest SAR
Obtain on tissue part.According to an embodiment of the present, coldplate groove 2394 may be oriented such that they hang down
The E- field components of the straight output in radiating guide 2364.According to an embodiment of the present, coldplate groove 2394 can be by
It is located so that E- field component of the electric wire perpendicular to the output of radiating guide 2364 of coldplate thermocouple 2395.According to the present invention
A kind of embodiment, coldplate groove 2394 may be oriented such that coldplate thermocouple 2395 electric wire be located at radiating guide
The E- field components of part under 2364 hole perpendicular to the output of radiating guide 2364.
According to an embodiment of the present, the proximal end face of coldplate 2340 can be positioned so that each scattering member of contact
The distal end of part 2378.According to an embodiment of the present, coldplate 2340, which can be selected to have, minimizes coldplate
The surface of hole in interface or defect between 2340 and the distal end of dispersing element 2378.A kind of according to the present invention implements
Example, the interface between coldplate 2340 and dispersing element 2378 can be designed to minimize the presence of material, the material bag
The disturbance of the interface or the air of focus and cooling fluid may be caused when launching microwave energy from radiating guide 2364 by including.
According to an embodiment of the present, coldplate 2340 can be substantially flat.According to an embodiment of the present, cool down
The flatness of plate 2340 can be less than approximate 0.0002 inch of surface change degree.According to an embodiment of the present, such as
Dielectric-epoxy resin（Such as Eccosorb epoxy resin）Binding agent can be used for by coldplate 2340 be attached to it is each dissipate
Penetrate element 2378.
According to an embodiment of the present, coldplate thermocouple 2395 can provide feedback to indicate coldplate 2340
Distal side near tissue temperature.According to an embodiment of the present, coldplate thermocouple 2395 can provide feedback
To indicate the temperature for the tissue being bonded in tissue cavity 2338.According to an embodiment of the present, coldplate thermocouple
2395 can be positioned in the coldplate groove 2394 of the distal side of coldplate 2340.According to an embodiment of the present,
Coldplate thermocouple 2395 can be by No. 0.39 copper of laser welding and constantan be made it is T-shaped.A kind of according to the present invention implements
Example, coldplate thermocouple 2395 can be printed on the distal side of coldplate 2340.According to an embodiment of the present, it is cold
But plate thermocouple 2395 may be oriented so that in microwave field by coldplate thermocouple 2395（Including coldplate thermocouple electricity
Line）Caused disturbance is minimized.According to an embodiment of the present, coldplate thermocouple 2395 may be oriented to make
Obtain coldplate thermocouple 2395（Including coldplate thermocouple electric wire）Influence to the SAR patterns of applicator 2320 is minimized.
According to an embodiment of the present, coldplate thermocouple 2395 may be oriented so that coldplate thermocouple 2395（Including
Thermocouple electric wire）Influence to the damage generation for the tissue being engaged with tissue cavity 2338 is minimized.According to the present invention's
A kind of embodiment, coldplate thermocouple 2395 may be oriented so that coldplate thermocouple wire perpendicular to radiating guide 2364
The E- fields of transmitting.According to an embodiment of the present, in order in the mechanical integrity of the holding wire of coldplate thermocouple 2395
While minimize the disturbance of microwave field, the wire of coldplate thermocouple 2395 can be selected at approximate No. 30 to approximate No. 40
Between and it is preferably approximate No. 39.According to an embodiment of the present, coldplate thermocouple 2395 can be positioned in
So that thermocouple weld seam is positioned at the hole of radiating guide 2364 on the distal side of coldplate 2340 under each radiating guide 2364
The centre of gap.According to an embodiment of the present, coldplate thermocouple 2395 can be positioned under each waveguide so as to
Thermocouple weld seam is located at the centre of dispersing element 2378.According to an embodiment of the present, coldplate thermocouple 2395 can be with
It is positioned in the groove on the surface of coldplate 2340, so that weld seam or thermocouple electric wire may not extend to coldplate groove
Outside 2394.According to an embodiment of the present, coldplate thermocouple 2395 can be positioned in the surface of coldplate 2340
On coldplate groove 2394 in, so that when disposable bioreactor part 2363 is attached to applicator 2320, weld seam or thermocouple electric wire are equal
Will not pushes against tissue biological barrier 2337 be more than approximate 0.003 inch.According to an embodiment of the present, coldplate thermocouple
2395 can be positioned in the coldplate groove 2394 on the surface of coldplate 2340, to be attached when disposable bioreactor part 2363
When applicator 2320 thermocouple weld seam and thermocouple electric wire will not pushes against tissue biological barrier 2337 so as in tissue biological
Air pocket is produced between the distal side of barrier 2337 and coldplate 2340.According to an embodiment of the present, coldplate thermocouple
2395 weld seams can be flattened so that it is guaranteed that they are fitted in coldplate groove 2394.According to an embodiment of the present,
The weld seam of coldplate thermocouple 2395 can be flattened approximate with least one so as to produce by approximate 0.008 inch cross-section
The weld seam of 0.004 inch cross-section, so as to ensure the weld seam of coldplate thermocouple 2395 may not extend to coldplate groove 2395 it
Outside.According to an embodiment of the present, the quantity of coldplate thermocouple 2395 may be approximately equal to ripple in aerial array 2355
The quantity of lead antenna 2364.According to an embodiment of the present, the quantity of coldplate thermocouple 2395 can be four, antenna
Each radiating guide 2364a-2364d one coldplate thermocouple of correspondence in array 2355.A kind of according to the present invention implements
Example, coldplate thermocouple 2395 is used for providing feedback to indicate the tissue being bonded in tissue cavity 2338 to generator 2301
Temperature.According to an embodiment of the present, coldplate thermocouple 2395 is used for providing feedback to indicate to generator 2301
Positioned at the temperature of the tissue of each lower section of radiating guide 2364.
Figure 19 is aerial array 2355, coolant cavity 2360, the and of separation rib 2393 according to an embodiment of the present
The perspective end view of dispersing element 2378.According to an embodiment of the present, waveguide assemblies 2358 can include multiple tunings
Element 2390 and multiple feeding connectors 2388.According to an embodiment of the present, Support Channel 2389 can be connected to
Coolant cavity 2360.
Figure 20 is aerial array 2355, coolant cavity 2360, the and of separation rib 2393 according to an embodiment of the present
The end-view of dispersing element 2378.According to an embodiment of the present, waveguide assemblies 2358 can include one or more
Radiating guide 2364a, 2364b, 2364c and 2364d.According to an embodiment of the present, waveguide assemblies 2358 can include
Multiple feeding connectors 2388.According to an embodiment of the present, radiating guide 2364 can include dielectric filler 2368
With wave guide wall 2366.According to an embodiment of the present, Support Channel 2389 can be connected to coolant cavity 2360.According to
A kind of embodiment of the present invention, coolant channel 2360a can be located at below radiating guide 2364a.According to one kind of the present invention
Embodiment, coolant channel 2360b can be located at below radiating guide 2364b.According to an embodiment of the present, cooling agent
Passage 2360c can be located at below radiating guide 2364c.According to an embodiment of the present, coolant channel 2360d can be with
Below radiating guide 2364d.According to an embodiment of the present, dispersing element 2378a can be positioned in cooling agent
In chamber 2360a.According to an embodiment of the present, dispersing element 2378b can be positioned in coolant cavity 2360b.Root
According to a kind of embodiment of the present invention, dispersing element 2378c can be positioned in coolant cavity 2360c.According to the one of the present invention
Embodiment is planted, dispersing element 2378d can be positioned in coolant cavity 2360d.According to an embodiment of the present, support
Passage 2389 may be adapted to supply cooling fluid to coolant cavity 2360.According to an embodiment of the present, separation rib 2393
Coolant cavity 2360a-2360d either side can be positioned in.
Figure 21 is the stereogram of applicator 2320 according to an embodiment of the present and disposable device 2363.According to
A kind of embodiment of the present invention, applicator 2320 can be latched mechanism 2365 and be attached to disposable device 2363.According to this hair
A kind of bright embodiment, applicator 2320 can include applicator cable 2334.According to an embodiment of the present, disposably
Device 2363 can include vacuum tube 2319, tissue cavity 2338, alignment feature 2352 and tissue boundary surface 2336.According to this hair
A kind of bright embodiment, alignment feature 2352 can be located in the appropriate placement that contributes to applicator 2320 during treating
At distance.According to an embodiment of the present, alignment feature 2352 can be positioned so that separately approximate 30.7 millimeters.According to this
A kind of embodiment of invention, alignment feature 2352, which can further be positioned and can be designed to auxiliary doctor, is applying energy
Prelocalization applicator 2320.According to an embodiment of the present, the alignment feature 2352 on disposable device 2363 is auxiliary
Help user to be properly positioned applicator before treatment and applicator is moved during surgical procedure to next area for treatment.
According to an embodiment of the present, when being used together with the mark or boundary mark in area for treatment, on disposable device 2363
Alignment feature 2352 help to create continuous damage.
Figure 22 is the end-view of the distal end of applicator 2320 shown in Figure 21 and disposable device 2363.According to the present invention's
A kind of embodiment, disposable device 2363 can include tissue biological's barrier 2337.According to an embodiment of the present, discharge
Device 2320 can include coldplate 2340 that can be for example behind tissue biological's barrier 2337.It is real according to one kind of the present invention
Example is applied, tissue biological's barrier 2337 can form the part on tissue boundary surface 2336.According to an embodiment of the present,
Disposable device 2363 can include vacuum ports 2342 and vacuum passage 2350.According to an embodiment of the present, vacuum
Port 2342 can for example be directly or indirectly connected to the disposable device of vacuum tube 2319 and vacuum passage 2350
Hole in 2363 distal ends, it can be formed by the groove in disposable device 2363.According to an embodiment of the present, breech lock
Mechanism 2365 can be used to contribute to disposable device 2363 is connected into applicator 2320.
Figure 23 is the exploded perspective view of applicator 2320 shown in Figure 21 and disposable device 2363.According to the one of the present invention
Embodiment is planted, applicator 2320 can include coldplate 2340, separation rib 2393, antenna holder 2374, the and of waveguide assemblies 2358
Duplexer 2357.According to an embodiment of the present, waveguide assemblies 2358 can include antenna 2364 (a-d).According to this
Invention a kind of embodiment, disposable device 2363 can include vacuum tube 2319, alignment feature 2352, latch component 2359,
Top vacuum cover 2345 and vacuum seal 2348.According to an embodiment of the present, top vacuum cover 2345 is covered and close
Seal at least a portion of main vacuum passage 2335（Figure 27）.
Figure 24 is the sectional view of applicator 2320 shown in Figure 21 and disposable device 2363.It is real according to one kind of the present invention
Example is applied, applicator 2320 can include aerial array 2355, duplexer 2357 and applicator cable 2334.According to the present invention's
A kind of embodiment, applicator cable 2334 can include coldplate thermocouple electric wire 2330, cooling agent thermocouple electric wire 2331, cold
But agent supply pipe 2312, cooling agent recurrent canal 2313, duplexer signal 2481, energy cable 2322.According to the one of the present invention
Embodiment is planted, coldplate thermocouple electric wire 2330 can include one or more thermocouple electric wires, and the thermocouple electric wire can
It is attached to one or more thermocouples with the output relative positioning of aerial array 2355.A kind of according to the present invention implements
Example, cooling agent thermocouple electric wire 2331 can include being attached to one of one or more cooling paths thermocouple 2326 or more
Multiple thermocouple electric wires, cooling path thermocouple 2326 can be positioned so that in measurement such as cooling agent recurrent canal 2313
Coolant fluid.According to an embodiment of the present, one or more cooling paths thermocouple 2326 can be positioned so that
Measurement cooling fluid 2361 flows through the temperature after coolant cavity 2360.According to an embodiment of the present, it is one or more
Individual cooling path thermocouple 2326 can be located in cooling agent recurrent canal 2313.According to an embodiment of the present, road is cooled down
Footpath thermocouple 2326 is used for after providing feedback to generator 2301 to indicate that cooling fluid 2361 flows through coolant cavity 2360
Temperature.According to an embodiment of the present, disposable device 2363 can include latch component 2359.
Figure 25 is the view of the distal end of disposable device 2363 according to an embodiment of the present.According to the present invention's
A kind of embodiment, disposable device 2363 can include tissue boundary surface 2336, tissue cavity 2338 and alignment feature 2352.Root
According to a kind of embodiment of the present invention, tissue boundary surface 2336 can form the rear wall of tissue cavity 2338.According to the one of the present invention
Embodiment is planted, tissue boundary surface 2336 can include tissue biological's barrier 2337, vacuum passage 2350 and vacuum ports 2342.
According to an embodiment of the present, disposable device 2363 includes alignment feature 2352 and vacuum tube 2319.
Figure 26 is the view of the proximal lateral of the disposable device 2363 shown in Figure 25.A kind of according to the present invention implements
Example, disposable device 2363 includes applicator chamber 2346.According to an embodiment of the present, can include can be with for applicator chamber
The applicator chamber 2346 formed at least in part by tissue biological's barrier 2337.According to an embodiment of the present, disposably
Device 2363 includes alignment feature 2352 and vacuum tube 2319.According to an embodiment of the present, disposable device 2363 can
With including top vacuum cover 2345.
Figure 27 is the view of the first paragraph of the proximal lateral of the disposable device 2363 shown in Figure 26, wherein eliminating top
Vacuum cover 2345.According to an embodiment of the present, disposable device 2363 can include applicator chamber 2346（It can include
Tissue biological's barrier 2337）, side vacuum cover 2347 and vacuum seal 2348.According to an embodiment of the present, side vacuum
Lid 2347 covers and seals at least a portion of main vacuum passage 2335.According to an embodiment of the present, disposable device
2363 can include applicator biological barrier 2332（It can be the polyethylene film that can be for example obtained from Fisher Scientific）
（TS）, vacuum passage 2333 and vacuum barrier 2343.According to an embodiment of the present, vacuum passage 2333 can be by vacuum
Vacuum ports 2342 and be connected to applicator biological barrier 2332 that connector 2328 is connected in tissue cavity 2338.According to this
A kind of embodiment of invention, the formation of vacuum passage 2333 reaches the directapath on tissue boundary surface 2336 and reaches applicator life
The indirect or roundabout of thing barrier 2332.According to an embodiment of the present, vacuum passage 2333 may be adapted to constraint from
Tissue cavity 2338 flows to the fluid motion of applicator biological barrier 2332.According to an embodiment of the present, vacuum coupling
2328 can be positioned in the side relative with applicator biological barrier 2332 of disposable device 2363, to work as applying vacuum
When advanced for air and produce long circuitous path.According to an embodiment of the present, from vacuum coupling 2328 to applicator
The indirect path of biological barrier 2332 be designed such that be more difficult to fluid is biological from tissue cavity 2338 towards applicator
Barrier 2332 is drawn, particularly when there is back pressure in vacuum passage 2333, such as by opening disposable device 2363 and hair
The vacuum solenoid 2315 between vavuum pump/driver 2307 in raw device, or tissue boundary table is pulled away from by tissue
Cause the back pressure in the interior vacuum produced of tissue cavity 2338 during face 2336.According to an embodiment of the present, vavuum pump
2450 and vacuum solenoid 2315 can be used for supporting tissue obtain applicator 2320.According to an embodiment of the present,
Main vacuum passage 2335 can extend to vacuum passage 2333 and applicator biological barrier 2332 from vacuum coupling 2328.According to
Main vacuum passage 2335 can be connected in tissue boundary surface 2336 by a kind of embodiment of the present invention, vacuum passage 2333
Vacuum ports 2342.According to an embodiment of the present, vacuum barrier 2343 can be positioned in vacuum passage 2333 and apply
Put in the main vacuum passage 2335 between device biological barrier 2332.According to an embodiment of the present, vacuum barrier 2343 can
It is suitable for helping to keep tissue to obtain the phase by providing the pressure drop between vacuum passage 2333 and applicator biological barrier 2332
Between air pressure in applicator chamber 2346 and tissue cavity 2338 it is of substantially equal.According to an embodiment of the present, vacuum is kept off
Plate 2343 can be positioned so that and be adapted to assist in during skin is obtained in balanced applicator chamber 2346 and tissue cavity 2338 more
Pressure between large quantity of air.According to an embodiment of the present, vacuum barrier 2343 may be adapted to be tied to up to applicator
The amount of the return pressure of biological barrier 2332.According to an embodiment of the present, vacuum barrier 2343 may be adapted to constrain and work as
When applying return pressure（For example after appropriate shut-off vacuum or skin is pushed out tissue cavity 2338 or leaves tissue boundary surface
When 2336）Reach the amount of the biofluid of applicator biological barrier 2332.According to an embodiment of the present, vacuum barrier
2343 can be positioned so that and suitable for producing pressure drop with so that the major part of any return pressure is released through vacuum passage
2333 enter tissue cavity 2338.According to an embodiment of the present, vacuum barrier 2343 may be adapted in vacuum loop 2341
Circuitous path in provide mechanical obstacles, the side of vacuum barrier 2343 when flowing through main vacuum passage 2335 which increase air
Pressure.According to an embodiment of the present, baffle plate may be adapted to provide mechanical obstacles is passed through main vacuum passage with increasing air
The length of circuitous path when 2335.According to an embodiment of the present, applicator biological barrier 2332 can be positioned in very
Between empty path 2333 and applicator chamber 2346.According to an embodiment of the present, applicator biological barrier 2332 can be
It may be adapted to the film through air but the biofluid of substantially impervious mistake such as blood and sweat.According to an embodiment of the present, apply
It can be hydrophobic membrane filter to put device biological barrier 2332.According to an embodiment of the present, applicator biological barrier 2332
It can be made up of polyethylene film nylon or other suitable materials.According to an embodiment of the present, applicator biological barrier
2332 can include hole, the size in the hole be enough to make enough air by with balanced vacuum without passing through biofluid.
According to an embodiment of the present, applicator biological barrier 2332 can include the hole with approximate 0.45 micron-scale.Root
According to a kind of embodiment of the present invention, when vacuum is switched on and before pressure is by equilibrium, applicator biological barrier 2332 can be with
Cause minimum pressure drop between vacuum passage 2333 and applicator chamber 2346.
Figure 28 is the view of the second segment of the proximal lateral of the disposable device 2363 shown in Figure 26, wherein it is true to eliminate top
Empty lid 2345.According to an embodiment of the present, disposable device 2363 can include applicator chamber 2346（Group can be included
Knit biological barrier 2337）With vacuum seal 2348.According to an embodiment of the present, disposable device 2363 can include
Vacuum passage 2333 and vacuum coupling 2328.According to an embodiment of the present, vacuum coupling 2328 can be by vacuum
Path 2333 is connected to vacuum tube 2319.
Figure 29 is the sectional view of the disposable device 2363 along Figure 25 H-H interceptions.According to an embodiment of the present,
Disposable device 2363 includes applicator chamber 2346 and tissue cavity 2338.According to an embodiment of the present, applicator chamber
2346 and tissue cavity 2338 can be separated at least in part by tissue biological's barrier 2337.According to an embodiment of the present,
Tissue cavity 2338 can include tissue boundary surface 2336 and cavity wall 2354.According to an embodiment of the present, tissue boundary
Surface 2336 can be formed by tissue biological's barrier 2337 at least in part.According to an embodiment of the present, disposable bioreactor
Part 2363 can include vacuum loop 2341.According to an embodiment of the present, vacuum loop 2341 can include vacuum tube
2319th, vacuum coupling 2328, vacuum barrier 2343, vacuum passage 2333 and applicator biological barrier 2332.According to the present invention
A kind of embodiment, tissue cavity 2338 by vacuum passage 2333 can be connected to vacuum tube 2319 by vacuum loop 2341.Root
According to a kind of embodiment of the present invention, vacuum loop 2341 can be connected applicator chamber 2346 by applicator biological barrier 2332
To vacuum tube 2319.According to an embodiment of the present, disposable device 2363 can include top vacuum cover 2345 and side
Vacuum cover 2347.According to an embodiment of the present, top vacuum cover 2345 and side vacuum cover 2347 can seal vacuum and return
Road 2341.
Figure 30 is one section of view of the disposable device 2363 shown in Figure 29.According to an embodiment of the present, one
Secondary property device 2363 includes applicator chamber 2346 and tissue cavity 2338.According to an embodiment of the present, applicator chamber 2346
It can be separated at least in part by tissue biological's barrier 2337 with tissue cavity 2338.According to an embodiment of the present, organize
Chamber 2338 can include tissue boundary surface 2336 and cavity wall 2354.According to an embodiment of the present, tissue boundary surface
2336 can be formed by tissue biological's barrier 2337 at least in part.According to an embodiment of the present, disposable device
2363 can include vacuum loop 2341.According to an embodiment of the present, vacuum loop 2341 can include vacuum barrier
2343rd, vacuum passage 2333 and applicator biological barrier 2332.According to an embodiment of the present, vacuum loop 2341 can be with
Tissue cavity 2338 is connected to by vacuum passage 2333.According to an embodiment of the present, vacuum loop 2341 can be by applying
Put device biological barrier 2332 and applicator chamber 2346 is connected to vacuum loop 2341.According to an embodiment of the present, once
Property device 2363 can include top vacuum cover 2345 and side vacuum cover 2347.
Figure 30 A be according to the alternate embodiments of the present invention figure 29 illustrates one section of disposable device 2363 regard
Figure.Figure 30 B be according to the present invention alternate embodiments figure 29 illustrates disposable device 2363 one section of view.Root
According to a kind of embodiment of the present invention, cavity wall 2354 can include compliant member（compliant member）2375.According to this hair
A kind of bright embodiment, compliant member 2375 can be formed by flexible material, the flexible material be, for example, rubber,（With softness
Plastics or rubber seal coating）Coating urethane foam, silicones, polyurethane or heat-sealing open celled foam.According to this hair
A kind of bright embodiment, compliant member 2375 can be positioned in around the outward flange of tissue cavity 2338 to contribute to acquisition group
Knit.According to an embodiment of the present, compliant member 2375 can be positioned so that around the outward flange of chamber opening 2339 to have
Help obtain tissue.According to an embodiment of the present, compliant member 2375 can aid in the uneven tissue of engagement, for example
Tissue in armpit.According to an embodiment of the present, compliant member 2375 can aid in the uneven tissue of engagement, example
Tissue such as in the exterior lateral area of armpit.According to an embodiment of the present, compliant member 2375 can be in skin and group
Knit between chamber 2338, particularly there is provided improved sealing characteristics at skin injustice.According to an embodiment of the present, it is soft
Soft ridge terrace 2375 can accelerate to obtain tissue in tissue cavity 2338, particularly at skin injustice.It is real according to one kind of the present invention
Example is applied, compliant member 2375 can have in approximate 0.15 English in the top of chamber opening 2339 when compliant member 2375 is uncompressed
Height between very little to approximate 0.40 inch.According to an embodiment of the present, it is soft when compliant member 2375 is uncompressed
Soft ridge terrace 2375 can have approximate 0.25 inch of height in the top of chamber opening 2339.
Figure 31 is the stereogram of antenna holder 2374 according to an embodiment of the present.It is real according to one kind of the present invention
Example is applied, antenna holder 2374 can include antenna cavity 2377 and support loop 2385.According to an embodiment of the present, support
Loop 2385 may be adapted to so that cooling fluid cycles through antenna holder 2374.According to an embodiment of the present, support
Loop 2385 can include at least one support storage tank 2387.According to an embodiment of the present, support loop 2385 can be with
Include an inlet and an outlet support storage tank 2387.
Figure 32 is the three-dimensional cutaway view of the antenna holder 2374 along the F-F interceptions in Figure 31.It is real according to one kind of the present invention
Example is applied, antenna holder 2374 can include antenna cavity 2377 and support loop 2385.According to an embodiment of the present, support
Loop 2385 may be adapted to so that cooling fluid cycles through the antenna holder 2374 as part cooling fluid path 2381.Root
According to a kind of embodiment of the present invention, cooling fluid path 2381 can be a part for cooling circuit 2376.According to the present invention's
A kind of embodiment, support loop 2385 can include an inlet and an outlet support storage tank 2387 and Support Channel 2389.According to this hair
The element in a kind of bright embodiment, support loop 2385 and cooling fluid path 2381 can be designed to contribute to fluid steady
Flow through support loop 2385 and cooling fluid path 2381.According to an embodiment of the present, support loop 2385 and cooling
The element of fluid path 2381 into fillet and can be leveled sliding to contribute to fluid steadily to flow through support loop 2385 and cooling
Fluid path 2381.
Figure 33 is the sectional view of the antenna holder 2374 along Figure 31 F-F interceptions.According to an embodiment of the present,
Support loop 2385 may be adapted to so that cooling fluid cycles through the antenna holder as part cooling fluid path 2381
2374.According to an embodiment of the present, cooling fluid path 2381 can include support loop 2385 and coolant cavity
2360.According to an embodiment of the present, can be by the way that coldplate 2340 to be fixed on to the distal end of antenna holder 2374 come shape
Into coolant cavity 2360.According to an embodiment of the present, can be for example, by coldplate 2340 be bonded into antenna holder
2374 and coldplate 2340 is fixed on antenna holder 2374.According to an embodiment of the present, cooling fluid path 2381
It can be a part for cooling circuit 2376.According to an embodiment of the present, support loop 2385 can include support storage
Groove 2387 and Support Channel 2389.According to an embodiment of the present, support loop 2385 and cooling fluid path 2381
Element can be designed to contribute to fluid steadily to flow through support loop 2385 and cooling fluid path 2381.According to the present invention's
The element in a kind of embodiment, support loop 2385 and cooling fluid path 2381 into fillet and can be leveled sliding to contribute to stream
Body steadily flows through support loop 2385 and cooling fluid path 2381.
Figure 34 is one section of three-dimensional cutaway view of the antenna holder 2374 along Figure 31 I-I interceptions.According to the one of the present invention
Embodiment is planted, antenna holder 2374 can include support loop 2385.According to an embodiment of the present, support loop 2385
Support storage tank 2387 and Support Channel 2389 can be included.
Figure 35 is the stereogram of aerial array 2355 according to an embodiment of the present.It is real according to one kind of the present invention
Example is applied, antenna holder 2374 can include sump inlet 2384 and antenna cavity 2377.According to an embodiment of the present, waveguide
Component 2358 can include one or more isolation elements 2391 being located between radiating guide 2364（May, for example, be can be from
The ECCOSORB MF-190 microwave absorbing materials that Emerson ＆ Cuming Microwave Products are obtained）.According to this
A kind of embodiment of invention, microwave energy can be provided to each radiating guide by feeding connector 2388.According to this hair
A kind of bright embodiment, waveguide assemblies 2358 can be kept together by waveguide assemblies framework 2353.According to one kind of the present invention
Embodiment, waveguide assemblies framework 2353 can include feeding bracket 2351 and component bolt 2349.It is real according to one kind of the present invention
Example is applied, aerial array 2355 can include antenna holder and at least one radiating guide 2364.A kind of according to the present invention implements
Example, aerial array 2355 can include one or more isolation elements 2391.According to an embodiment of the present, antenna array
Row 2355 can include four radiating guides 2364.According to an embodiment of the present, in aerial array 2355 waveguide day
The height of line 2364 can be staggeredly with contribute to it is sensible feeding connector 2388.
Figure 36 is the sectional view of the aerial array 2355 along Figure 35 L-L interceptions.According to an embodiment of the present, ripple
Guide assembly 2358 includes one or more radiating guides 2364, one or more feeding brackets 2351 and one or more
Isolation element 2391.According to an embodiment of the present, waveguide assemblies 2358 include radiating guide 2364a, 2364b, 2364c
And 2364d.According to an embodiment of the present, radiating guide 2364 can include dielectric filler 2368, wave guide wall 2366
With tuned cell 2390.According to an embodiment of the present, can be by using the appropriate coating material such as copper, gold, silver
Plating dielectric filler 2368 manufactures radiating guide 2364.According to an embodiment of the present, plating or electricity can be passed through
Plate dielectric fill material, such as dielectric filler 2368, to form wave guide wall 2366.According to an embodiment of the present, may be used
By direct plating or plating dielectric fill material, all faces in addition to hole is radiated are covered, to form wave guide wall 2366.
According to an embodiment of the present, copper can be preferred coating material.According to an embodiment of the present, dispersing element
2378 can also be individual component.According to an embodiment of the present, dispersing element 2378 can also be for example by poly- carbonic acid
Ester or the individual component of aluminum oxide formation.According to an embodiment of the present, dispersing element 2378 can also be located at cooling
Individual component in agent chamber 2360.According to an embodiment of the present, dispersing element 2378 can also be located at coolant cavity
2360 interior and individual components placed in the middle in the hole of radiating guide 2363.
Figure 37 is the view of the first paragraph of the sectional view of the aerial array 2355 shown in Figure 36.It is real according to one kind of the present invention
Example is applied, waveguide assemblies 2358 can include one or more radiating guides 2364 (a-d) and one or more isolation elements
2391.According to an embodiment of the present, isolation element 2391 can be positioned in radiating guide 2364 and waveguide assemblies
Between 2358 either side.According to an embodiment of the present, coolant cavity 2360（Heat exchanger channels can also be referred to as）Can
It is suitable for receiving cooling fluid（It is not shown）.
Figure 38 is the stereogram of the second segment of the sectional view of aerial array 2335 shown in Figure 36.It is real according to one kind of the present invention
Example is applied, waveguide assemblies 2358 can include one or more radiating guides 2364 (b-d) and one or more isolation elements
2391.According to an embodiment of the present, radiating guide 2364 can include dielectric filler 2368 and wave guide wall 2366.Root
According to a kind of embodiment of the present invention, coolant cavity 2360（Heat exchanger channels can also be referred to as）It may be adapted to receive cooling fluid
（It is not shown）.
Figure 39 is the 3rd section of view of the sectional view of the aerial array 2355 shown in Figure 36.It is real according to one kind of the present invention
Apply example, coolant cavity 2360（Heat exchanger channels can also be referred to as）It may be adapted to receive cooling fluid（It is not shown）.According to this hair
A kind of bright embodiment, separation rib 2393 can be supported by rib keeper 2396.According to an embodiment of the present, member is scattered
The power loss that part 2378 can be designed, position and be sized to propagate in tissue cavity 2388 produced by the tissue of engagement is close
Spend pattern or SAR patterns.According to an embodiment of the present, dispersing element 2378 can be by identical with dielectric filler 2368
Material formed.According to an embodiment of the present, dispersing element 2378 can be with the low of approximate 10 dielectric constant
Dielectric material is lost.According to an embodiment of the present, dispersing element 2378 can have to be approximately equal to filler material
The lower loss material of the dielectric constant of 2368 dielectric constant.According to an embodiment of the present, dispersing element 2378
Preferably there is the dielectric constant different from the dielectric constant of cooling fluid.According to an embodiment of the present, dispersing element
2378 is preferably low-loss, the energy that will not weaken or dissipate from the hole transmitting of radiating guide 2364 so as to it.According to
A kind of embodiment of the present invention, the loss that dispersing element 2378 has can be in frequency-of-interest（Such as 5.8 GHz）It is less than
Approximate 1.According to an embodiment of the present, for the dispersing element 2378 with low-loss cooling fluid, it can be excellent
Selection of land has the dispersing element of higher consume so as to extremely efficient size（EFS）, the effective field size can be defined as mesh
Mark the ratio between the radiation hole of the 50 percent SAR profiles and antenna in tissue cross-sections.According to one kind of the present invention
Embodiment, dispersing element 2378 can be formed by aluminum oxide or Eccostock materials.According to an embodiment of the present, dissipate
The laminar flow for contributing to cooling agent to surround dispersing element 2378 can be shaped as by penetrating element 2378.A kind of according to the present invention implements
Example, dispersing element 2378 can be shaped as the generation for minimizing the bubble flowed through in the cooling agent of cooling chamber 2360.According to this
A kind of embodiment of invention, dispersing element 2378 can be formed and be positioned to cooling and the microwave property of optimization system.According to
The present invention a kind of embodiment, dispersing element 2378 can be formed and be positioned to minimize dispersing element 2378 covered it is cold
But the area of plate.According to an embodiment of the present, dispersing element 2378 can be formed and be positioned to maximize in tissue
The target depth in tissue that chamber 2338 is engaged is in the cross-sectional area of the peak value SAR in target area.
According to an embodiment of the present, dispersing element 2378 can be located at the center of the hole of radiating guide 2364.
According to an embodiment of the present, dispersing element 2378 can be rectangle, with the size with the hole of radiating guide 2364
Proportional size.According to an embodiment of the present, dispersing element 2378 can be ellipse.According to one kind of the present invention
Embodiment, dispersing element 2378 can be track type, and the track type elongate sides parallel to the hole of radiating guide 2364
Longest edge.According to an embodiment of the present, dispersing element 2378 can have at approximate 1 millimeter to approximate between 7 millimeters
Length.According to an embodiment of the present, dispersing element 2378 can have approximately with the hole of radiating guide 2364
Long side equally long length.According to an embodiment of the present, dispersing element 2378 can have it is approximate at 1 millimeter to approximate
Width between 4 millimeters.According to an embodiment of the present, dispersing element 2378 can have approximately with radiating guide 2364
Hole short side equally long width.According to an embodiment of the present, dispersing element 2378 can have approximate half milli
The height of rice.According to an embodiment of the present, dispersing element 2378 can have the depth for being approximately equal to coolant cavity 2360
The height of degree.According to an embodiment of the present, dispersing element 2378 can have the face with the hole of radiating guide 2364
The proportional area of product.
According to an embodiment of the present, dispersing element 2378 can be positioned in the dielectric filling of radiating guide 2364
Between the proximal lateral of thing 2368 and coldplate 2340.According to an embodiment of the present, dispersing element 2378 can be positioned
Into both proximal end faces of contact dielectric filler 2368 and coldplate 2340.According to an embodiment of the present, member is scattered
Part 2378 can be positioned so that air gap to minimize or eliminate the joint between dispersing element 2378 and coldplate 2340 or
The mode of other discontinuities is against coldplate 2340.According to an embodiment of the present, dispersing element 2378 can be such as
Coldplate is attached to using dielectric-epoxy resin.According to an embodiment of the present, dispersing element 2378 can be positioned
It will not be assembled again into the field for causing radiating guide 2364 to produce when propagating through coldplate 2340.According to one kind of the present invention
Embodiment, dispersing element 2378 can be positioned in the center of coolant cavity 2360, and every side of dispersing element 2378 has
Equal flow path.According to an embodiment of the present, dispersing element 2378 may be oriented so that dispersing element
2378 longest dimension is alignd along cooling fluid by the path of coolant cavity 2360.According to an embodiment of the present, dissipate
The center in maximum E- field intensities region of the transmitting of radiating guide 2364 can be positioned in by penetrating element 2378.
Figure 40 is aerial array 2355, coolant cavity 2360, the and of separation rib 2393 according to an embodiment of the present
The end-view of dispersing element 2378.According to an embodiment of the present, coolant channel 2360c can be located at radiating guide
2364c lower section.
According to an embodiment of the present, cooling circuit 2376 can include cooling fluid 2361, coolant conduit
2324th, cooling fluid path 2381, cooling agent supply pipe 2312, cooling agent recurrent canal 2313 and refrigerant distribution pipe 2314.Root
According to a kind of embodiment of the present invention, cooling fluid path 2381 can include support loop 2385, coldplate 2340 and cooling agent
Chamber 2360.According to an embodiment of the present, cooling fluid path 2381 can include support loop 2385, coldplate
2340th, coolant cavity 2360 and refrigerant distribution pipe 2314.According to an embodiment of the present, the quilt of refrigerant distribution pipe 2314
For providing the continuous flowing by support loop 2385 and coolant cavity 2360.According to an embodiment of the present, cool down
Fluid 2361 can include water, deionized water or other appropriate fluid.According to an embodiment of the present, cooling fluid 2361
Applicator 2320 is cycled through from the coolant source 2310 outside applicator 2320 and returns to coolant source 2310.According to the present invention
A kind of embodiment, cooling fluid 2361 can enter cooling fluid path 2381 and by cold by cooling agent supply pipe 2312
But agent recurrent canal 2313 leaves cooling fluid path 2381.According to an embodiment of the present, cooling agent recurrent canal 2313 can
Including thermocouple, such as path thermocouple 2326 is cooled down, to measure the temperature for the cooling fluid 2361 for leaving cooling circuit 2376
Degree.According to an embodiment of the present, water-stop binding agent can be used to keep the element in cooling fluid path 2381
In place.According to an embodiment of the present, the binding agent with low water absorbable can be used by cooling fluid path 2381
Element be held in place.According to an embodiment of the present, can use epoxy resin,（Obtained from TraCon）Tri-
Element in cooling fluid path 2381 is held in place by Bond FDA-16 or UV curable adhesive.According to the one of the present invention
Embodiment is planted, curved surface and rounded edges can be used to reduce or eliminate turbulent flow in whole coolant fluid path 2381.
According to an embodiment of the present, curved surface and rounded edges can be used to subtract in whole coolant fluid path 2381
Less or eliminate bubble.According to an embodiment of the present, hydrophilic coating can be used for selected in cooling fluid path 2381
To reduce or eliminate turbulent flow on surface.According to an embodiment of the present, hydrophilic coating can be used for cooling fluid path
To reduce or eliminate bubble on selected surface in 2381.According to an embodiment of the present, support loop 2385 includes cold
But the path that the transmission of fluid 2361 passes through antenna holder 2374.According to an embodiment of the present, support loop 2385 can be with
It is configured to serial loop or parallel circuits.According to an embodiment of the present, support loop 2385 all or part of
Water wetted material can be coated with to contribute to the gentle flowing of cooling agent and minimize the generation of bubble, particularly in cooling agent
In chamber 2360.According to an embodiment of the present, for example coolant cavity 2360 is flowed through parallel in cooling fluid 2361
In the case of, support loop 2385 can include support storage tank 2387, including feed tray storage tank 2387 and return support storage tank
2387.According to an embodiment of the present, support storage tank 2387 may be used as fluid appearance reservoir（fluidic
capacitor）, so that the flowing of the cooling fluid 2361 between cooling agent supply pipe 2312 and coolant cavity 2360 is put down
It is slow.According to an embodiment of the present, support storage tank 2387 can keep enough cooling fluid amounts to ensure across all
The pressure of coolant cavity 2360 is substantially impartial.According to an embodiment of the present, support storage tank 2387 can keep enough
Cooling fluid amount is to ensure that the flow rate across all coolant cavities 2360 is substantially impartial.According to an embodiment of the present, prop up
The volume of frame storage tank 2387 can be selected to the balanced pressure across Support Channel 2389.A kind of according to the present invention implements
Example, the volume of support storage tank 2387 can be selected to the balanced flow rate across Support Channel 2389.According to one kind of the present invention
Embodiment, it is balanced across Support Channel 2389 that return support storage tank 2387 can be designed to have equidistant Support Channel 2389
Pressure.According to an embodiment of the present, wherein cooling fluid 2361 traverses through each cooling chamber 2360, passes through branch
The flowing in frame loop 2385, each Support Channel 2389 is directly connected to cooling chamber 2360 and in the opposite side of cooling chamber 2360
With return Support Channel 2389.According to an embodiment of the present, entrance and return Support Channel are by cooling agent distribution pipe
2314 connections.According to an embodiment of the present, wherein cooling fluid 2361 flows through each cooling chamber 2360 parallel, and support leads to
Support storage tank 2387 is extended to coolant cavity 2360 by road 2389 parallel.According to an embodiment of the present, Support Channel
2389 size, shape and position is selected to ensure that by the flow rate of each coolant cavity be equal.According to the present invention
A kind of embodiment, for all Support Channels 2389, the size and dimension of Support Channel 2389 can be identical.Root
According to a kind of embodiment of the present invention, the input of Support Channel 2389 can be with spaced at equal intervals across the bottom of support storage tank 2387.Root
According to a kind of embodiment of the present invention, size, shape and the position of Support Channel 2389 can be selected to minimize coolant cavity
Turbulent flow and bubble in 2360.According to an embodiment of the present, from support storage tank 2387 to the input of Support Channel 2389.
According to an embodiment of the present, Support Channel 2389 is in support storage tank 2387 and between the input of coolant cavity 2360
One section of cross section can be formed as wineglass or nozzle shape and lead to the input of coolant cavity 2360 being flared cooling agent
The width of chamber 2360.According to an embodiment of the present, the relative cross-sectional of Support Channel 2389 can be formed as having and put down
Smooth wall.According to an embodiment of the present, can be with rounding to the transition of coolant cavity 2360 from Support Channel 2389.Root
According to a kind of embodiment of the present invention, coolant cavity 2360 can include separation rib 2393.According to an embodiment of the present, flow
Cooling fluid through coolant cavity 2360 can have in 200 ml/mins between 450 ml/mins and preferably
The flow rate of 430 ml/mins（TS）.According to an embodiment of the present, coolant cavity 2360 can be designed to ensure that stream
Flow rate through each coolant cavity 2360 is essentially identical.According to an embodiment of the present, coolant cavity 2360 is flowed through
Cooling fluid can have between 8 degrees Celsius to 22 degrees Celsius and preferably approximate 15 degrees Celsius of temperature.According to the present invention
A kind of embodiment, coolant cavity 2360 can be positioned between the hole of radiating guide 2364 and coldplate 2340.According to
A kind of embodiment of the present invention, dispersing element 2378 is extended at least a portion of coolant cavity 2360.According to this hair
A kind of bright embodiment, dispersing element 2378 may extend through coolant cavity 2360.According to an embodiment of the present, it is cold
But the element of agent chamber 2360 can be leveled the sliding Laminar Flow to promote the fluid by coolant cavity 2360.According to the present invention
A kind of embodiment, the element of coolant cavity 2360 can be leveled the sliding generation to reduce bubble in coolant cavity 2360.Root
According to a kind of embodiment of the present invention, the dispersing element extended in coolant cavity 2360 can be promoted laminar flow and be prevented with rounded angle
Only in coolant cavity 2360 bubble generation.According to an embodiment of the present, the right-angle side or point in coolant cavity 2360
Angle can cause have undesirable flow behavior when cooling fluid moves across coolant cavity 2360, including produce bubble.Root
According to a kind of embodiment of the present invention, separation rib 2393 can be used to separate each coolant cavity 2360.According to the present invention's
A kind of embodiment, separation rib 2393 can be configured to ensure that each coolant cavity 2360 is respectively provided with essentially identical cross section.
According to an embodiment of the present, separation rib 2393 can have square cross section and be approximate 0.030 inch × 0.030
The size of inch.According to an embodiment of the present, greater or lesser separation rib 2393 is utilized to ensure that each cold
But the cross-sectional area of agent chamber 2360 is equal.According to an embodiment of the present, separation rib 2393 can be positioned so that
So that they do not contact the arbitrary portion of coldplate or radiating guide 2364.According to an embodiment of the present, separation rib
2393 may be oriented such that they contribute to the balanced cooling across coldplate 2340.A kind of according to the present invention implements
Example, separation rib 2393 can be sized to cause them to have the separation being equal to or less than between the hole of radiating guide 2364
The width of distance.According to an embodiment of the present, separation rib 2393 can be dimensioned and be located so that their not positions
In the hole of radiating guide 2364.According to an embodiment of the present, separation rib 2393 can be dimensioned and be positioned to make
They minimize when pass through coolant cavity 2360 when microwave field disturbance.According to an embodiment of the present, separation rib
2393 can be dimensioned and be located so that they minimize when pass through coolant cavity 2360 when microwave field interruption.According to this
A kind of embodiment of invention, can be by the rib keeper 2396 that is placed on separation rib 2393 at the either end of coolant cavity 2360
Interior next tab-delimited rib 2393.According to an embodiment of the present, separation rib 2393 may be oriented such that they do not connect
Touch dispersing element 2378.According to an embodiment of the present, separation rib 2393 can be positioned in away from the near of coldplate 2340
At the suitable distance of end surfaces one and preferably at the distance of approximate 0.010 inch of the proximal end face away from coldplate 2340.Root
According to a kind of embodiment of the present invention, separation rib 2393 can be made up of the material of interruption or the disturbance of minimum microwave field.According to
A kind of embodiment of the present invention, separation rib 2393 can be by that will not decay（Decline）Or the material of decrease cooling fluid is made.Root
According to a kind of embodiment of the present invention, separation rib 2393 can be made up of makrolon material.According to an embodiment of the present,
Separation rib 2393 can be made up of the material of the isolation between increase radiating guide.According to an embodiment of the present, separation rib
2393 can be made up of the material of the SAR patterns in improvement tissue.According to an embodiment of the present, separation rib 2393 can be with
It is made up of Eccosorb.According to an embodiment of the present, separation rib 2393 can be made and be applied by Eccosorb
To prevent the decay cooling fluid of separation rib 2393.
Figure 41 is the stereogram of waveguide assemblies 2358 according to an embodiment of the present.It is real according to one kind of the present invention
Example is applied, waveguide assemblies 2358 can include being located at radiating guide 2364a to one or more isolation elements between 2364d
2391.According to an embodiment of the present, waveguide assemblies 2358 can include multiple tuned cells 2390 and multiple feedings connect
Connect device 2388.According to an embodiment of the present, microwave energy can be supplied to each ripple by feeding connector 2388
Lead antenna.According to an embodiment of the present, waveguide assemblies 2358 can be kept together by waveguide assemblies framework 2353.Root
According to a kind of embodiment of the present invention, waveguide assemblies framework 2353 can include feeding bracket 2351 and component bolt 2349.
Figure 42 is the side view of the waveguide assemblies shown in Figure 41.According to an embodiment of the present, dispersing element 2378
At the output for being positioned in radiating guide 2364.According to an embodiment of the present, the output of radiating guide 2364 can also
It is referred to as the hole of antenna 2364.According to an embodiment of the present, dispersing element 2378a can be positioned in radiating guide
At 2364a output.According to an embodiment of the present, dispersing element 2378b can be positioned in radiating guide 2364b's
At output.According to an embodiment of the present, dispersing element 2378c can be positioned at radiating guide 2364c output.
According to an embodiment of the present, dispersing element 2378d is to be positioned at radiating guide 2364d output.
Figure 43 is the sectional view of the G-G interceptions of waveguide assemblies 2358 shown in Figure 41 and dispersing element 2378.According to this
A kind of embodiment of invention, waveguide assemblies 2358 include one or more radiating guides 2364, one or more feeding supports
Frame 2351 and one or more isolation elements 2391.According to an embodiment of the present, waveguide assemblies 2358 include waveguide
Antenna 2364.According to an embodiment of the present, radiating guide 2364 can include dielectric filler 2368, wave guide wall 2366
With tuned cell 2390.According to an embodiment of the present, can be by using appropriate coating material plating dielectric filler
2369 manufacture radiating guide 2364.According to an embodiment of the present, feeding pad 2397 can be used to work as wave guide wall
2366 to feed the matched waveguide antenna 2364 of connector 2388 when being plated on dielectric filler 2368, so that it is guaranteed that center
Appropriate contact between insulator 2398 and dielectric filler 2368.
Figure 44 is one section of view of the sectional view of the waveguide assemblies 2358 shown in Figure 43.A kind of according to the present invention implements
Example, waveguide assemblies 2358 include one or more radiating guides 2364, it is one or more feeding bracket 2351 and one or
More isolation elements 2391.According to an embodiment of the present, waveguide assemblies 2358 include radiating guide 2364.According to this
A kind of embodiment of invention, radiating guide 2364 can include dielectric filler 2368, wave guide wall 2366 and tuned cell 2390.
According to an embodiment of the present, feeding pad 2397 can be used for when wave guide wall 2366 is plated on dielectric filler
Cause to feed the matched waveguide antenna 2364 of connector 2388 when on 2368, so that it is guaranteed that central insulator 2398 and dielectric filler
Appropriate contact between 2368.
According to an embodiment of the present, isolation element 2391 can be designed between isolation radiating guide 2364
Interact and balance inner waveguide antenna（Such as radiating guide 2364a and 2364d）With external wave lead antenna（Such as radiating guide
2364b and 2364c）The loading condition run into.According to an embodiment of the present, isolation element 2391 can absorb not by
A part for the microwave energy being coupled in the tissue that tissue cavity 2338 is engaged.According to an embodiment of the present, isolate
Element 2391 can absorb the fringing field existed at the metal edge of the hole of radiating guide 2364.According to one kind of the present invention
Embodiment, isolation element 2391 can be designed and be positioned to ensure that each radiating guide 2364 in each of radiating guide 2364
Side is respectively provided with identical load characteristic.
According to an embodiment of the present, such as embodiment illustrated in fig. 13, when the outer conductive wall quilt of radiating guide 2364
It is machined to ensure the conductive material between the dielectric filler 2368 of adjacent waveguide antenna 2364（Such as wave guide wall 2366）
Width when can be for all 2364 all sames of radiating guide in aerial array 2355, then can save for isolation element
2391 demand.According to an embodiment of the present, external wave lead antenna 2364a and 2364d wave guide wall 2366 can be by machine
It is dimensioned such that such wave guide wall 2366 is thick as the distance between adjacent waveguide antenna 2364 in aerial array 2355.Root
According to a kind of embodiment of the present invention, radiating guide 2364 can be subtly configured so that wave guide wall on all sides
2366 thickness is equal, so as to save the demand for isolation element 2391.
According to an embodiment of the present, isolation element 2391 can be positioned between antennas and in aerial array
The outside of external wave lead antenna 2364a and 2364d in 2355 are so as to isolate radiating guide 2364.A kind of according to the present invention implements
Example, isolation element 2391 can be positioned so that provides symmetrical microwave for all radiating guides 2364 in aerial array 2355
Loading condition.According to an embodiment of the present, isolation element 2391 can be made up of the material of absorption microwave energy.According to
A kind of embodiment of the present invention, isolation element 2391 can be made up of Eccosorb.According to an embodiment of the present, rise and decline
Cooling fluid can be terminated to by subtracting the isolation element 2391 of effect.
According to an embodiment of the present, isolation element 2391 can be designed and be positioned to minimize adjacent waveguide day
Interacting and balancing the load that adjacent waveguide antenna 2364 is run between line 2364.If radiating guide too close to
Together, then the SAR patterns that they are produced can be asymmetric or without equal intensities.If radiating guide 2364 too far away from,
Then damage will be discontinuous.According to an embodiment of the present, the sky between the dielectric filler 2368 in aerial array 2355
Between can by the thickness of the wave guide wall 2366 of radiating guide 2364 and one or more isolation between microwave antenna member
The thickness of part is constituted.According to an embodiment of the present, the space between the dielectric filler 2368 in aerial array 2355
Can be between approximate 0.012 inch to 0.080 inch and preferably approximate 0.030 inch.According to the one of the present invention
Embodiment is planted, aerial array 2355 can have the wave guide wall 2366 with approximate 0.003 inch of thickness of coating, isolation element 2391
There can be approximate 0.024 inch of thickness.According to an embodiment of the present, wherein frequency-of-interest is approximately 5.8
GHz, isolation element 2391 can have between approximate 25 to approximate 40 and preferably approximate 27 dielectric constant.According to this hair
A kind of bright embodiment, wherein frequency-of-interest are approximately 5.8 GHz, and isolation element 2391 can have approximate 0.02 near
Like between 0.07 and preferably approximate 0.04 loss angle tangent（tanδ）.According to an embodiment of the present, wherein feeling emerging
Interesting frequency is approximately 5.8 GHz, and isolation element 2391 can have in approximate 1.5+j3.4 to approximate 7+j5.6 and preferably near
Like 2.7+j3.4 complex permeability.
Figure 45 is the side view of the alternate embodiments of waveguide assemblies according to an embodiment of the present.Figure 46 is figure
The sectional view of waveguide assemblies shown in 45.According to an embodiment of the present, microwave choke 2386 can also be used as every
From element 2391.According to an embodiment of the present, the short metallic gasket between radiating guide 2364 can be used（Setting
At away from waveguide hole back fixation distance）Microwave choke is formed with the metal rim on outside microwave antenna 2364
2386.According to an embodiment of the present, microwave choke 2386 can be used in waveguide assemblies 2358 to realize ripple
Isolation and SAR uniformity between the inner waveguide antenna 2364 of guide assembly 2358.According to an embodiment of the present, in radiating guide
In space between 2364, there are specific thicknesses by using be set in hole specified distance away from radiating guide 2364
Metallic gasket separates radiating guide 2364 so as to producing microwave choke 2386.According to an embodiment of the present, exist
The outside of external wave lead antenna 2364, using by being set in away from being constituted at hole same distance and with the metallic gasket of identical size
Flange and extend to the metallic plate of waveguide surface to realize microwave choke 2386 from pad.A kind of according to the present invention implements
Example, microwave choke 2386 produces for the fringing field that the long edge position of the radiating surface of the hole of radiating guide 2364 is present and propagates road
Footpath.According to an embodiment of the present, microwave choke structure allows this margin signal in waveguide assemblies 2358
It is coupled in a symmetrical in microwave choke 2386 for interior microwave antenna and outer microwave antenna 2364.Therefore, microwave is gripped
Stream circle 2386 can strengthen the isolation in waveguide assemblies 2358 by reducing the interaction between adjacent waveguide antenna 2364,
And strengthen the SAR patterns between radiating guide 2364 by introducing symmetrical loading condition at the hole of radiating guide 2364
Uniformity.
Figure 47 is the schematic diagram of system 2309 according to an embodiment of the present.A kind of according to the present invention implements
Example, system 2309 can include isolating transformer 2316, coolant source 2310, generator 2301 and applicator 2320.According to this
A kind of embodiment of invention, isolating transformer 2316 may be connected to AC power supplies 2318.According to an embodiment of the present,
Isolating transformer 2316 can provide power to generator 2301 and coolant source 2310.According to an embodiment of the present,
Generator 2301 can include D/C power 2303, controller 2302, microwave links 2403（It may, for example, be a series of microwave components）
And vacuum source 2308.According to an embodiment of the present, controller 2302 can manage all system levels inputs and
Control, for example：Power and timing setting from front panel 2305；Input from starting button 2464；From stop button
2466 input；Hardware error from microwave circuit（Reverse power error, amplifier failures）；Temperature from applicator and
Alignment error；And transmit measurement data to interface 2420 to record reverse power, forward power and tissue temperature in discrete instants
Degree and coolant temperature.According to an embodiment of the present, controller 2302 can also control duplexer 2357, vavuum pump
2450 and vacuum solenoid 2315.According to an embodiment of the present, vacuum source 2308 can include vavuum pump/driver
2307 and vacuum solenoid 2315.According to an embodiment of the present, D/C power 2303 can be to microwave links 2403 and control
Device 2302 provides power.According to an embodiment of the present, controller 2302 may insure microwave links 2403 by standardized operation.
According to an embodiment of the present, microwave links 2403 may be connected to controller 2302.A kind of according to the present invention implements
Example, controller 2302 can be connected to vavuum pump/driver 2307 by vacuum power signal 2323, and control letter by solenoid
Numbers 2321 are connected to vacuum solenoid 2315.According to an embodiment of the present, D/C power 2303 can be for example can be from
The PM650-12C type Switching Power Supplies for medical 650 watt of+12 volt that Tumbler Technologies are obtained.According to the one of the present invention
Embodiment is planted, vavuum pump 2450 can be the 15988 model rotating vanes that can be for example obtained from Clark Flow Solutions
Pump.According to an embodiment of the present, vacuum solenoid 2315 can be for example can be from Peter Paul Electronics
The normally closed LW53KK8DGBG12/DC types magnetic valve of threeway for being discharged into atmospheric environment that Co is obtained.A kind of according to the present invention implements
Example, applicator 2320 can be connected to generator 2301 by applicator cable 2334.According to an embodiment of the present, discharge
Device cable 2334 can include coolant conduit 2324, energy cable 2322, cooling agent thermocouple electric wire 2331, coldplate thermoelectricity
Even electric wire 2330 and duplexer signal 2481.According to an embodiment of the present, coolant conduit 2324 can be connected
To coolant source 2310.According to an embodiment of the present, coolant conduit 2324 can include cooling agent supply pipe 2312
With cooling agent recurrent canal 2313.According to an embodiment of the present, cooling agent can be supplied by cooling agent supply pipe 2312
To applicator 2320.According to an embodiment of the present, cooling agent returns to coolant source by cooling agent recurrent canal 2313
2310.According to an embodiment of the present, energy cable 2322 can be connected to generator by microwave out connector 2443
2301.According to an embodiment of the present, energy cable 2322 can be by microwave out connector 2443 by applicator
Duplexer 2357 in 2320 is connected to the microwave links 2403 in generator 2301.According to an embodiment of the present, it is cold
But agent thermocouple electric wire 2331 and antenna thermocouple electric wire 2330 can be connected to generator 2301 by temperature connector 2482.Root
According to a kind of embodiment of the present invention, cooling agent thermocouple electric wire 2331 can be by temperature connector 2482 by applicator 2320
Cooling path thermocouple 2326 be connected to controller 2302 in generator 2301.According to an embodiment of the present, it is cold
But plate thermocouple electric wire 2330 can be connected the coldplate thermocouple 2395 in applicator 2320 by temperature connector 2482
To the controller 2302 in generator 2301.According to an embodiment of the present, duplexer signal 2481 can be by antenna
Switching connector 2480 is connected to generator 2301.According to an embodiment of the present, duplexer signal 2481 can lead to
Cross the controller that the duplexer 2357 in applicator 2320 is connected in generator 2301 by duplexer connector 2480
2302.According to an embodiment of the present, disposable device 2363 can be connected to generator 2301 by vacuum tube 2319, its
In the vacuum tube 2319 can include generator biological barrier 2317.According to an embodiment of the present, in system 2309,
Vacuum tube 2319 can be connected to generator 2301 by vacuum ports connector 2484.According to an embodiment of the present, very
Disposable device 2363 can be connected to vacuum solenoid 2315 by blank pipe 2319 by vacuum ports connector 2484.According to this
A kind of embodiment of invention, coolant source 2310 is by cooling fluid 2361（It is not shown）It is fed to applicator 2320.According to this hair
A kind of bright embodiment, coolant source 2310 can be the NanoTherm coolers that can be obtained from ThemoTek, Inc.According to
A kind of embodiment of the present invention, the cooling fluid 2361 from coolant source 2310 has approximate between 5 to 40 degrees Celsius
Temperature range and preferably approximate 15 degrees Celsius of temperature.According to an embodiment of the present, coolant source 2310 can be with
Flow rate between approximate 200 to 1000 ml/min and preferably approximate 500 mm/min.According to the present invention's
A kind of embodiment, coolant source 2310 can be configured to refrigeration cooling fluid 2361 and by the cooling fluid 2361 freezed
Pumping passes through applicator 2320 and coolant cavity 2360 to protect the skin being bonded in tissue cavity 2338 consolidating from heat injury
State cooler.According to an embodiment of the present, coolant source 2310 can be configured to refrigeration cooling fluid 2361 simultaneously
The cooling fluid 2361 freezed is pumped by applicator 2320 and coolant cavity 2360 and is bonded on tissue cavity 2338 to protect
Solid-state cooler of the first layer of interior skin from heat injury.
Figure 48 is the schematic diagram of microwave links 2403 according to an embodiment of the present.A kind of according to the present invention implements
Example, oscillator 2304 may be connected to isolator 2401a, and isolator 2401a may be connected to switch 2402（Can be
Such as single pole single throw SPST reflectivity pin type diode switches）, the switch 2402 may be connected to attenuator 2408a（Can be with
It is such as fixed attenuator）, attenuator 2408a may be connected to bandpass filter 2404, and the bandpass filter 2404 can
To be connected to amplifier 2306, the amplifier 2306 may be connected to isolator 2401b, and isolator 2401b can be by
It is connected to directional coupler 2406.According to an embodiment of the present, oscillator 2304 can have approximate 5.8 GHz's defeated
Go out frequency.According to an embodiment of the present, oscillator 2304 provides 5.8 stable GHz low-power level signals.According to this hair
A kind of bright embodiment, isolator 2401a can be used to protect oscillator 2304 from the reflection work(from amplifier 2306
Rate signal.According to an embodiment of the present, filter circuit includes bandpass filter 2404, and the bandpass filter 2404 has
Centre frequency at frequency-of-interest.According to an embodiment of the present, filter circuit includes bandpass filter 2404, should
Bandpass filter 2404 has the centre frequency at approximate 5.8 GHz.According to an embodiment of the present, filter circuit bag
The bandpass filter 2404 included can be the waveguide cavity filter for the frequency band input for eliminating ingoing power amplifier.According to the present invention
A kind of embodiment, the bandpass filter 2404 that filter circuit includes can have approximate 25MHz three dB bandwidth.According to this hair
A kind of bright embodiment, amplifier 2306 can be adapted for the amplifier of the amplified signal at frequency-of-interest.According to the present invention
A kind of embodiment, amplifier 2306 can be adapted for the amplifier of the amplified signal at 5.8 GHz.According to one kind of the present invention
Embodiment, amplifier 2306 can be the S51500-05 amplifiers that can be obtained from Locus Microwave.According to the present invention's
A kind of embodiment, amplifier 2306 can include internal bias circuit, match circuit and suitable for maintain stability and feel it is emerging
The control circuit of appropriate matching and power output is provided under interesting frequency.According to an embodiment of the present, amplifier 2306 can
It is suitable for input signal amplifying 54dB.According to an embodiment of the present, isolator 2401b can be used for guard amplifier
2306 from reflected power signal.According to an embodiment of the present, energy cable 2322 can be carried from directional coupler
2406 leave the microwave energy of microwave links 2403.According to an embodiment of the present, directional coupler 2406 can be further
It is connected to the attenuator 2408b that may connect to power detector 2409b.According to an embodiment of the present, power detection
Device 2409b output can be forward power signal 2415.According to an embodiment of the present, directional coupler 2406 can be with
It is further connected to the attenuator 2408c that may connect to power detector 2409a.According to an embodiment of the present, one
Measurement forward direction and reverse power can be used for power detector 2409b and 2409a.According to an embodiment of the present,
Attenuator 2409a output can be reverse power signal 2417.According to an embodiment of the present, microwave links 2403 can be with
It is connected to microwave control signal 2413.According to an embodiment of the present, microwave control signal 2413 can include PWM controls
Signal 2405 processed, fault-signal 2407, purified signal 2411, forward power signal 2415 and reverse power signal 2417.According to
A kind of embodiment of the present invention, pwm control signal 2405 may be connected to switch 2402.A kind of according to the present invention implements
Example, fault-signal 2407 can be produced by amplifier 2306.According to an embodiment of the present, purified signal 2411 can be by
It is connected to amplifier 2306.According to an embodiment of the present, power detector 2409 can be for example with the pole of screw alley two
Pipe detector.
According to an embodiment of the present, by comparing the forward power signal measured at directional coupler 2406
2415 and from the request power of power control knob 2454 come cause power controller work.A kind of according to the present invention implements
Example, power can be sampled by directional coupler 2406 from the output of amplifier 2306, and wherein directional coupler 2406 is connected to
Power detector 2409b.According to an embodiment of the present, directional coupler 2406 can be used for sending positive and reflection work(
Rate is come for detector 2409a and 2409b（It can be for example coaxial tunnel diode detector）Power is provided.According to the present invention's
A kind of embodiment, can by the change-over circuit in controller 2302 come readout power detector 2409a and 2409b output simultaneously
It is fed back to the switch 2402 of the input of control amplifier 2306.According to an embodiment of the present, switch 2402 is accounted for
Empty factor can control the power output level from microwave links 2403, wherein switch 2402 in connect percent times with
The percentage of the peak power output produced from microwave links 2403 is proportional.According to an embodiment of the present, accounted for when with 40%
During empty factor driving switch 2402, the microwave links with 100 watts of maximum outputs can provide 40 watts of outputs from microwave links 2403.Root
According to a kind of embodiment of the present invention, switch 2402 can work at the modulating frequency when the output of pin type diodes is linear.
According to an embodiment of the present, switch 2402 can work at approximate 7.2 kHz modulating frequency.
Figure 49 is the schematic diagram of controller 2302 according to an embodiment of the present.A kind of according to the present invention implements
Example, modulate circuit 2410a may be connected to analog-digital converter 2412a, and analog-digital converter 2412a may be connected to forward direction
Power look-up table 2414, the forward power look-up table 2414 may be connected to multiplexer and UART（Universal Asynchronous Receive
Device/transmitter）State machine 2418, the state machine 2418 may be connected to interface 2420（Can be for example segregate RS232
Interface）.According to an embodiment of the present, forward power look-up table 2414 can also be connected to comparator 2424（Can be with
It is such as digital comparator）, the comparator 2424 may be connected to pulse width modulation state machine 2422, the state machine 2422
It may be connected to logic 2438.According to an embodiment of the present, including the duty factor circuit of logic 2438 can be by
For providing pulse width modulation（PWM）Control signal 2405 is to control the power output level by energy cable 2322.
According to an embodiment of the present, modulate circuit 2410b may be connected to analog-digital converter 2412b, the analog-digital converter
2412b may be connected to reverse power look-up table 2416, and the reverse power look-up table 2416 may be connected to multiplexing
Device and UART state machines 2418 and fault logic 2434.According to an embodiment of the present, reverse power look-up table 2416
The voltage from power detector 2409a is nursed one's health with modulate circuit 2410b, to produce the pattern measurement of reverse power.According to
A kind of embodiment of the present invention, reverse power look-up table 2416 and modulate circuit 2410b are that circuit downstream outputs signals to note
The reverse power of measurement is recorded, or makes safety decision-making.According to an embodiment of the present, modulate circuit 2410c can connect
Be connected to analog-digital converter 2412c, analog-digital converter 2412c may be coupled to multiplexer and UART state machines 2418 and
Fault logic 2434.According to an embodiment of the present, modulate circuit 2410d may be connected to analog-digital converter 2412d,
Analog-digital converter 2412d may be connected to multiplexer and UART state machines 2418 and fault logic 2434.According to
A kind of embodiment of the present invention, multiplexer 2426 may be connected to day a line options state machine master controller 2442, the master
Controller 2442 may be connected to time status machine 2440, and the time status machine 2440 may be connected to logic 2438.Root
Select state machine master controller 2442 to control to use multi-path antenna array there is provided circuit antenna according to a kind of embodiment of the present invention
Antenna conversion in 2355 applicator 2320.According to an embodiment of the present, multiplexer 2426 can be connected
To modulate circuit 2410d.According to an embodiment of the present, day line options state machine master controller 2442 may be connected to
Logic 2438.According to an embodiment of the present, analog-digital converter 2412e may be connected to comparator 2424 and multichannel is multiple
With device and UART state machines 2418 and fault logic 2434.
According to an embodiment of the present, microwave links 2403 are connected to switch 2402 by microwave control signal 2413.Root
According to a kind of embodiment of the present invention, forward power signal 2415 can be modulate circuit 2410a input.According to the one of the present invention
Embodiment is planted, reverse power signal 2417 can be modulate circuit 2410a input.According to an embodiment of the present, it is cold
But agent temperature signal 2431 can be modulate circuit 2410c input.According to an embodiment of the present, antenna thermocouple electricity
Cable 2433 can be the input of multiplexer 2426.According to an embodiment of the present, riding partitioned signal 2437 can be
The input of timer state machine 2440.According to an embodiment of the present, power control signal 2453 can be analog-to-digital conversion
Device 2412e input.According to an embodiment of the present, the coolant temperature signal 2461 filtered can be modulate circuit
2410c output.According to an embodiment of the present, the antenna temperature signal 2459 filtered can be modulate circuit
2410d output.According to an embodiment of the present, antenna selection signals 2463 can be a day line options state machine main control
The input and output of device 2442.According to an embodiment of the present, stop signal 2467 can be timer state machine 2440
Input and output.According to an embodiment of the present, start signal 2465 can be the input of timer state machine 2440
And output.According to an embodiment of the present, it is rear cold（post-cool）Timer-signals 2473 can be timer state machine
2440 input and output.According to an embodiment of the present, energy timer-signals 2471 can be timer state machine
2440 input and output.According to an embodiment of the present, pre-coo time signal 2469 can be timer state machine
2440 input and output.According to an embodiment of the present, buzzerphone 2479 can be the output of logic 2438.According to
A kind of embodiment of the present invention, ready signal 2477 can be the output of logic 2438.According to an embodiment of the present, spiral shell
Spool control signal 2321 can be the output of logic 2438.According to an embodiment of the present, duplexer signal 2481
Can be the output of logic 2438.According to an embodiment of the present, pwm control signal 2405 can be the defeated of logic 2438
Go out.According to an embodiment of the present, purified signal 2411 can be the output of logic 2438.It is real according to one kind of the present invention
Example is applied, duplexer signal 2490 can be the input of fault logic 2434.According to an embodiment of the present, fault-signal
2475 can be the output of fault logic 2434.According to an embodiment of the present, fault-signal 2475 can be logic
2438 and the input of timer state machine 2440.According to an embodiment of the present, serial signal 2445 may be connected to
Interface 2420.
According to an embodiment of the present, controller 2302 and microwave links 2403 can include pulse width modulation
（PWM）Servo control mechanism is to provide feedback to control the power output of amplifier 2306.According to an embodiment of the present, arteries and veins
Rushing width modulated servo control mechanism can be with controlling switch 2402（Can be pin type diode switches）, attenuator 2408b and 2408c,
Change-over circuit in power detector 2409a and 2409b and controller 2302.According to an embodiment of the present, can be with
Power output is controlled by the duty factor for controlling the signal of amplifier 2306 to input.According to an embodiment of the present,
The input power of amplifier 2306 can be maintained during transmission cycle to ensure the stability in amplifier 2306 and linear.
According to an embodiment of the present, controller 2302 produces pwm control signal 2405 to control to switch 2402
System leaves the power of microwave links 2403.According to an embodiment of the present, by being revolved from the Power Control on front panel 2305
Button 2454 obtains power control signal 2453（It can be such as input reference voltage）To cause controller 2302 to work.According to this
A kind of embodiment of invention, when user is by pressing starting button 2464 come initialization power, power control signal 2453
It is used to produce request forward power by controller 2302.According to an embodiment of the present, after a short period of time, duty factor electricity
Road will be operated according to the feedback measured from forward power detector 2409b.According to an embodiment of the present, reality will be performed
Border measures the comparison of forward power signal 2415 and request forward power.According to an embodiment of the present, controller 2302
Minor adjustment will be made to pwm control signal 2405 forward power for leaving microwave links 2403 is maintained at into the positive work(of request
In the specification of rate setting.According to an embodiment of the present, pwm control signal 2405 can be in approximate 7.0 KHz and approximate
Between 7.5 KHz and preferably approximate 7.2 KHz.According to an embodiment of the present, pwm control signal 2405 can be near
Like absolutely.
According to an embodiment of the present, forward power look-up table 2414 and modulate circuit 2410a（Filtering can be included
And amplifying circuit）The voltage from power detector 2409b is nursed one's health to produce the pattern measurement of forward power.According to the present invention
A kind of embodiment, it is tested that forward power look-up table 2414 and modulate circuit 2410a are that circuit downstream outputs signals to record
The forward power of amount, or make control and safety decision-making.According to an embodiment of the present, forward power look-up table 2414
The output voltage signal for representing measured forward power is produced with modulate circuit 2410a.According to an embodiment of the present,
Forward power look-up table 2414 can be calibrated so that the characteristic of compensation each power detector 2409b and amplifier 2306.Root
According to a kind of embodiment of the present invention, reverse power look-up table 2416 can specifically be calibrated to compensate single power detector
2409a and amplifier 2306 characteristic.
Figure 50 is the schematic diagram of rear board 2311 according to an embodiment of the present.A kind of according to the present invention implements
Example, rear board 2311 includes foot-operated switch connector 2436 and serial interface connector 2444.A kind of according to the present invention implements
Example, foot-operated switch connector 2436 may be connected to foot-operated partitioned signal 2437.According to an embodiment of the present, serial interface
Mouth connector 2444 may be connected to serial signal 2445.
Figure 51 is the schematic diagram of front panel 2305 according to an embodiment of the present.A kind of according to the present invention implements
Example, front panel 2305 can include power control knob 2454, vacuum control knob 2456, temperature connector 2482, antenna and open
Close connector 2480, vacuum meter measuring device 2486, vacuum ports connector 2484, antenna selection switch 2462, temperature indicator
2457th, starting button 2464, stop button 2466, microwave out connector 2443, precooling timer 2468, energy timer
2470th, rear cold timer 2472, fault detector 2474, ready indicator 2476 and buzzer 2478.According to the one of the present invention
Embodiment is planted, temperature connector 2482 can include coolant temperature connector 2430 and one or more antenna temperatures are connected
Device 2429.According to an embodiment of the present, antenna temperature connector 2429 can include antenna temperature connector 2429a extremely
Antenna temperature connector 2429d.According to an embodiment of the present, temperature indicator 2457 can be shown including antenna temperature
Device 2458 and coolant temperature display 2460.
According to an embodiment of the present, user interface can be generator front panel 2305, and it includes user's input
Control piece（Such as power control knob 2454, vacuum control knob 2456, starting button 2464, stop button 2466, day line selection
Select switch 2462, precooling timer 2468, energy timer 2470, rear cold timer 2472）, user feedback features（Such as vacuum
Meter 2486, antenna selection switch 2462, temperature indicator 2457, precooling timer 2468, energy timer 2470 and after
Cold timer 2472）And connector（Such as temperature connector 2482, vacuum ports connector 2484, duplexer connector
2480 and microwave out connector 2443）.According to an embodiment of the present, during energy is transmitted, for each selected
Radiating guide 2364 measures tissue temperature, and the tissue temperature is shown in front panel 2305 by antenna temperature display 2458
On.According to an embodiment of the present, during energy is transmitted, coolant temperature is continuously measured and by cooling agent temperature
Display 2460 is shown on front panel 2305.According to an embodiment of the present, can be by engaging appropriate day line selection
Select button（For example it is associated with the energy select button of antenna selection switch 2462）, so as to be the microwave energy from front panel 2305
Amount transmission selection radiating guide 2364.According to an embodiment of the present, it can be transmitted during the predetermined power timing period
Energy selectes radiating guide 2364 to each.
According to an embodiment of the present, can to provide user anti-for such as user interface of generator front panel 2305
Feedback.According to an embodiment of the present, user feedback can be waveguide battle array including the use of such as antenna temperature display 2458
Each radiating guide display cooling plate temperature in row（It can indicate that skin temperature）.According to an embodiment of the present,
User feedback can show the applicator at the output in cooling fluid path including the use of such as coolant temperature display 2460
Interior cooling fluid temperature.According to an embodiment of the present, user feedback can be including the use of such as vacuum meter measuring device
2486 indicate the vacuum pressure at vacuum output.According to an embodiment of the present, user feedback can include ready indicate
Device, such as ready indicator 2476, to indicate when that system is ready for using.According to an embodiment of the present, user
Feedback can include fault detector, such as fault detector 2474, to indicate when to break down.According to one kind of the present invention
Embodiment, what the report before initialization treatment cycle of antenna temperature display 2458 started positioned at first connects waveguide day
Temperature at the coldplate thermocouple 2395 of the lower section of line 2364.According to an embodiment of the present, in coldplate thermocouple
The temperature measured at 2395 can indicate that the skin positioned at the lower section of tissue biological's barrier 2337 of neighbouring coldplate thermocouple 2395
The temperature on skin surface.According to an embodiment of the present, at coldplate thermocouple 2395 measure temperature can with it is neighbouring
The temperature proportional of the skin surface of the lower section of tissue biological's barrier 2337 of coldplate thermocouple 2395.According to one kind of the present invention
Embodiment, once treatment cycle, then antenna temperature display 2458 is with regard to reporting under each radiating guide 2364 upon start up
The temperature of the tissue of side, and once complete treatment cycle, then antenna temperature display 2458 continues to show the ripple finally started
The tissue temperature of the lower section of lead antenna 2364.
According to an embodiment of the present, power control signal 2453 can be the output of power control knob 2454.
According to an embodiment of the present, vacuum control input signal 2455 can be the output of vacuum control knob 2456.According to
A kind of embodiment of the present invention, cooling agent thermocouple electric wire 2331 can be the input of coolant temperature connector 2430.According to
A kind of embodiment of the present invention, coolant temperature signal 2431 can be the output of coolant temperature connector 2430.According to this
A kind of embodiment of invention, coldplate thermocouple electric wire 2330 can be the input of antenna temperature connector 2429.According to this hair
A kind of bright embodiment, antenna thermocouple cable 2433 can be the output of antenna temperature connector 2429.According to the present invention's
A kind of embodiment, duplexer signal 2481 can be the input of duplexer connector 2480.It is real according to one kind of the present invention
Example is applied, duplexer signal 2490 can be the output of duplexer connector 2480.According to an embodiment of the present, day
Line options signal 2463 can be the input and output of antenna selection switch 2462.According to an embodiment of the present, filtered
The antenna temperature signal 2459 of ripple can be the input of antenna temperature display 2458.According to an embodiment of the present, quilt
The coolant temperature signal 2461 of filtering can be the input of coolant temperature display 2460.A kind of according to the present invention implements
Example, start signal 2465 can be the input and output of starting button 2464.According to an embodiment of the present, stop signal
2467 can be off the input and output of button 2466.According to an embodiment of the present, energy cable 2322 can be
The input of microwave out connector 2443.According to an embodiment of the present, pre-coo time signal 2469 can be precooling meter
When device 2468 input and output.According to an embodiment of the present, when energy timer-signals 2471 can be energy meter
The input of device 2470.According to an embodiment of the present, rear cold timer-signals 2473 can be rear cold timer 2472
Input and output.According to an embodiment of the present, fault-signal 2475 can be the input of fault-signal 2474.According to this
A kind of embodiment of invention, ready signal 2477 can be the input of ready indicator 2476.A kind of according to the present invention implements
Example, buzzerphone 2479 can be the input of buzzer 2478.
Figure 52 is the schematic diagram of vacuum source 2308 according to an embodiment of the present.A kind of according to the present invention implements
Example, vacuum source 2308 can include vacuum solenoid 2315 and vavuum pump/driver 2307.A kind of according to the present invention implements
Example, vavuum pump/driver 2307 can include variable voltage driver 2452 and vavuum pump 2450.It is real according to one kind of the present invention
Apply example, vacuum control input signal 2455 can be the input of variable voltage driver 2452, and solenoid control signal
2321 can be the input of vacuum solenoid 2315.According to an embodiment of the present, solenoid control signal 2321 can be with
It is the input of vacuum solenoid 2315.According to an embodiment of the present, vavuum pump/driver 2307 can be connected by pipe 2427
It is connected to vacuum solenoid 2315.
Figure 53 is the schematic diagram of Controller Circuit Used in Microwave Power Amplifier 2419 according to an embodiment of the present.According to the one of the present invention
Embodiment is planted, Controller Circuit Used in Microwave Power Amplifier can be adapted for the pulse width modulation of the energy output at control 2322（PWM）Control electricity
Road.According to an embodiment of the present, Controller Circuit Used in Microwave Power Amplifier 2419 can include oscillator 2304, isolator 2401a, switch
2402nd, attenuator 2408a, bandpass filter 2404, amplifier 2306, isolator 2401b and directional coupler 2406.According to this
A kind of embodiment of invention, purified signal 2411 can be the input of amplifier 2306.According to an embodiment of the present, it is micro-
Ripple control circuit 2419 can have output energy cable 2322, and the output energy cable 2322, which can be carried, is delivered to applicator
2320 microwave energy.According to an embodiment of the present, Controller Circuit Used in Microwave Power Amplifier 2419 can include attenuator 2408b and
2408c, power detector 2409a and 2409b.According to an embodiment of the present, power detector 2409a output can be with
It is reverse power signal 2417.According to an embodiment of the present, power detector 2409b output can be forward power
Signal 2415.According to an embodiment of the present, reverse power signal 2417 can be reverse power look-up table and conditioning electricity
The input on road 2423.According to an embodiment of the present, reverse power look-up table and modulate circuit 2423 can be exported inversely
Power error signal 2428.According to an embodiment of the present, reverse power look-up table and modulate circuit 2423 can be exported
Reverse power reading 2435.According to an embodiment of the present, forward power signal 2415 can be forward power look-up table
With the input of modulate circuit 2421.According to an embodiment of the present, energy transmission ON/OFF signal 2439 can be positive work(
The input of rate look-up table and modulate circuit 2421.According to an embodiment of the present, power control signal 2453 can be just
To the input of power look-up table and modulate circuit 2421.According to an embodiment of the present, forward power look-up table and conditioning
Circuit 2421 can have the input of reverse power look-up table and modulate circuit 2423.According to an embodiment of the present, just
Positive output power error 2441 can be exported to power look-up table and modulate circuit 2421.A kind of according to the present invention implements
Example, forward power look-up table and modulate circuit 2421 can export positive output power error 2441.According to one kind of the present invention
Embodiment, forward power look-up table and modulate circuit 2421 can export forward power signal 2446.According to one kind of the present invention
Embodiment, forward power look-up table and modulate circuit 2421 can export forward power signal to duty factor circuit 2425
2446.According to an embodiment of the present, power control signal 2453 and start signal 2465 can be duty factor circuits
2425 input.According to an embodiment of the present, two modules, using forward power look-up table and modulate circuit 2421 with
And positive and reverse power reading is converted into available control signal and failure letter by reverse power look-up table and modulate circuit 2423
Number.According to an embodiment of the present, look-up table is included in reverse power look-up table and modulate circuit 2423 to produce
The raw output voltage signal for representing tested reverse power.According to an embodiment of the present, reverse power look-up table and conditioning
Each look-up table in circuit 2423 is calibrated to diode and amplifier in circuit.
Figure 54-58 is the schematic diagram of patient's location equipment 2492 according to an embodiment of the present.According to the present invention
A kind of embodiment, patient's location equipment 2492 include arm support member 2493.According to an embodiment of the present, patient positions
Equipment 2492 includes center support 2494.According to an embodiment of the present, patient's location equipment 2492 includes substrate
2495.According to an embodiment of the present, patient's location equipment 2492 includes head rest 2496.A kind of according to the present invention implements
Example, patient's location equipment 2492 can be used for correctly positioning patient.According to an embodiment of the present, according to the present invention's
The angle that a kind of arm support member 2493 of embodiment can be formed with center support 2494 between approximate 15 degree to approximate 35 degree
（A）.According to an embodiment of the present, arm support member 2493 according to an embodiment of the present can be with central supported
Part 2494 forms approximate 25 degree of angle.According to an embodiment of the present, according to an embodiment of the present patient determines
Position equipment 2492 can have approximate 22 centimetres of size between arm support member 2493（B）.A kind of according to the present invention implements
Example, patient's location equipment 2492 can also include disposable cover（It is not shown）, it can be replaced for each patient.
Figure 59 is the schematic diagram for the treatment of model 2483 according to an embodiment of the present.It is real according to one kind of the present invention
Example is applied, treatment model 2483 can be flexible and transparent substrate.According to an embodiment of the present, appropriate treatment model 2483
The multiple openings for being arranged to predetermined pattern can be included.According to an embodiment of the present, each opening or every group of opening can
Be used to recognize particular treatment element.According to an embodiment of the present, opening or opening group（Such as device position point
2487）The area for indicating the area for treatment that will place applicator 2320 can be used for.A kind of according to the present invention implements
Example, opening or opening group（For example applicator places mark 2489）It can be used to indicate and will place applicator alignment feature
2352 skin.According to an embodiment of the present, opening or opening group（Such as anesthesia injection mark 2485）Can by with
In sign will injecting narcotic skin.According to an embodiment of the present, fiber crops are injected under the center of antenna hole
Liquor-saturated dose can increase the predictability of result and reduce the amount of fluid every time needed for treatment.A kind of according to the present invention implements
Example, the mark on model can also be used to indicate that out according to the applicator position on armpit can use in array how many days
Line.According to an embodiment of the present, the hole in model（Such as boundary mark alignment identification 2491）Alignment can also be used to control
Treat model 2493 and the boundary mark with patient（For example tatoo, temporary tatt, skin are superfluous, skin folding line, hair pattern, fashionable mark
Know or birthmark）.
Figure 60 is the simple sectional view of the medical treatment device 2300 for engaging tissue according to an embodiment of the present.
In the embodiment of the present invention shown in Figure 60, skin 1307 is bonded in tissue cavity 2338.In the embodiment of the present invention shown in Figure 60
In, corium 1305 and hypodermis 1303 are engaged with tissue cavity 2338.In the embodiment of the present invention shown in Figure 60, skin surface
1306 are engaged with tissue cavity 2338 so that skin surface 1306 contacts at least a portion of cavity wall 2354, and thermally contacts
At least a portion of coldplate 2340.In the embodiment of the present invention shown in Figure 60, skin surface 1306 is engaged with tissue cavity
In 2338 so that skin surface 1306 contacts at least a portion of organizational interface 2336.As shown in figure 60, vacuum pressure can be by
For lifting corium 1305 and hypodermis 1303, so that corium 1305 and hypodermis 1303 be separated from muscle 1301.As shown in figure 60,
Vacuum pressure can be used for lifting corium 1305 and hypodermis 1303, so that by corium 1305 and hypodermis 1303 from 1301 points of muscle
From for example to protect muscle 1301 by limiting or eliminating the electromagnetic energy of arrival muscle 1301.
Figure 61-64 shows the tissue contours and simplification figure of medical treatment device 2300 according to an embodiment of the invention.According to
A kind of embodiment of the present invention, waveguide assemblies 2358 can include radiating guide 2364.According to an embodiment of the present, it is all
Electromagnetic energy such as microwave energy can be radiated in corium 1305 by tissue first 2362, and the tissue first 2362 may, for example, be
Integral type or attached disposable device 2363.According to an embodiment of the present, medical treatment device 2300 can include cooling
Agent chamber 360 and coldplate 2340.Can be such as peak value SAR, peak energy in the embodiment of the present invention shown in Figure 61-64
Consuming the peak value of density or peak temperature can produce in the first tissue region 1309.It is real in the present invention shown in Figure 61-64
Apply in example, can be that the amplitude of the reduction of the temperature of SAR, the power dissipation density of reduction or the reduction of such as reduction is produced the
In two tissue regions 1311, and the amplitude further reduced is in the 3rd tissue regions 1313 and the 4th tissue regions 1315.Such as
Shown in Figure 61-64, corium 1305 is located away from hypodermis 1303 by interface 1308.As shown in Figure 61, Figure 63 and Figure 64, interface 1308 can
To be idealized as substantially straight line, to simplify description, but as shown in Figure 64, in actual tissue, interface 1308 can
To be non-linear, discontinuous, coarse interface, it can also be included across many institutional frameworks with interruption organizational interface 1308
With institutional framework group.As shown in Figure 61-64, hypodermis 1303 is located on musculature 1301.A kind of according to the present invention implements
Example, electromagnetic radiation can be launched with the frequency between such as 5-6.5 GHz.According to an embodiment of the present, electromagnetism spoke
Penetrating can be launched with for example approximate 5.8 GHz frequency.According to an embodiment of the present, field extension device 2379（Can be with
E.g. dispersing element 2378）It can be located in coolant cavity 2360.In an embodiment of the present invention, for example implement shown in Figure 64
In example, field extension device 2379 can be used for such as extension and flatten the first tissue region 1309.It is real in the present invention shown in Figure 64
Apply in example, field extension device 2379 can be used for such as extension and flatten the damage of formation in the first tissue region 1309.According to this
A kind of embodiment of invention, produces damage, and for example producing the damage shown in Figure 61-64 can be used to treat patient skin.Root
According to a kind of embodiment of the present invention, damage is produced, for example producing the damage shown in Figure 61-64 can be used to injuring or destroying knot
Sweat gland in structure, such as patient skin.
According to an embodiment of the present, disposable device 2363 includes a large amount of beneficial aspects.According to the one of the present invention
Embodiment is planted, vacuum pressure can be evenly distributed to the either side of tissue biological's barrier 2337.A kind of according to the present invention implements
Example, when realizing balanced, vacuum pressure may be uniformly distributed in tissue cavity 2338 and applicator chamber 2346.According to the one of the present invention
Embodiment is planted, ensure that tissue biological's barrier 2337 will fit using extensible tissue biological's barrier 2337 and Vacuum Balance
The distal end of applicator 2320 is so as to prevent from forming bubble between the distal end of tissue biological's barrier 2337 and applicator 2320.According to
A kind of embodiment of the present invention, tissue biological's barrier is ensure that using extensible tissue biological's barrier 2337 and Vacuum Balance
The distal side of 2337 laminating coldplates 2340 is so as to prevent between the distal side of tissue biological's barrier 2337 and coldplate 2340
Form bubble.According to an embodiment of the present, Vacuum Balance ensure that tissue biological's barrier 2337 is sealed in applicator
2320 distal end and the surface for being sealed in the skin being bonded in tissue cavity 2338, so that reduce or eliminating to cause
The air pocket of undesirable disturbance in microwave field.According to an embodiment of the present, Vacuum Balance ensure that tissue biological's barrier
2337 are sealed in the distal side of coldplate 2340 and are sealed in the surface for the skin being bonded in tissue cavity 2338, so that
The air pocket of undesirable disturbance in microwave field may be caused by reduce or eliminating.
According to an embodiment of the present, stretch tissue biological's barrier 2337 and ensure that it is flatted against in applicator 2320
Distal end.According to an embodiment of the present, tissue biological's barrier 2337 is stretched so as to which the distal end with applicator 2320 is formed
Substantially wrinkle-free interface.According to an embodiment of the present, stretch tissue biological's barrier 2337 and cause tissue biological's barrier
Interference engagement is produced between 2337 and the distal end of applicator 2320.According to an embodiment of the present so that applicator 2320
Distal end extend in tissue cavity 2338 so that tissue biological's barrier 2337 stretches and ensure that the He of tissue biological's barrier 2337
Interference engagement between the distal end of applicator 2320.According to an embodiment of the present, applicator 2320 can be recessed to and apply
Put device intracavitary and be up to approximate 0.020 inch.According to an embodiment of the present, the distal end of applicator 2320 extends to group
Knit in chamber 2338 0-0.030 inches and preferably approximate 0.010 inch so that tissue biological's barrier 2337 stretch and
Interference engagement is produced between the distal end of applicator 2320 and tissue biological's barrier 2337.According to an embodiment of the present, do
The combination for relating to the vacuum coordinated and in applicator chamber 2346 allows to otherwise in extensible tissue biological's barrier 2337
Air pocket, folding line and the fold of interior generation are minimized.
According to an embodiment of the present, biofluid can be isolated from generator by generator biological barrier 2317
2301.According to an embodiment of the present, biofluid can be isolated from applicator 2320 by applicator biological barrier 2332.
According to an embodiment of the present, biofluid can be isolated from applicator 2320 by tissue biological's barrier 2337.According to this
A kind of embodiment of invention, applicator biological barrier 2332 provides the isolation between tissue cavity 2338 and applicator 2320, from
And allow air to pass through but prevent biofluid or other fluids（Such as KY Jelly）Reach applicator 2320.According to the present invention
A kind of embodiment, the circuitous path in vacuum barrier 2343 and vacuum loop 2341 contributes to biofluid or other fluids
It is isolated from applicator biological barrier 2332.According to an embodiment of the present, applicator biological barrier 2332, vacuum loop
Circuitous path, vacuum barrier 2343 in 2341 and the combination before vacuum passage 2333 is placed in into vacuum barrier 2343 are prevented
Back pressure（The issuable back pressure for example when by make it that vacuum tube is divulged information to terminate to vacuumize with atmospheric pressure）Drive life
Logistics body or other fluids enter applicator chamber 2346.According to an embodiment of the present, applicator biological barrier 2332 can
Can be obtained from Harrington Plastics with approximate 0.1 micron to 1.0 microns and preferably approximate 0.45 micron
Aperture hydrophobic filter.
According to an embodiment of the present, applicator 2320 includes a large amount of beneficial aspects.It is real according to one kind of the present invention
Apply example, aerial array 2355 helps to produce big damage or damage field in the case where the single of applicator 2320 is placed.According to this hair
A kind of bright embodiment, aerial array 2355 helps to create the damage of up to approximate 30 millimeters × approximate eight millimeters of cross sections
Wound.According to an embodiment of the present, rapid translating microwave between the radiating guide 2364 in aerial array 2355 is passed through
Energy can aid in generation continuous damage.According to an embodiment of the present, by the way that microwave energy is applied into antenna array
Selected radiating guide 2364 in row 2355 can aid in the discontinuous damage of generation.According to an embodiment of the present, lead to
The selected radiating guide 2364 that microwave energy is applied in aerial array 2355 is crossed to can aid on tissue boundary surface
Damage is produced under 2336 part.According to an embodiment of the present, aerial array 2355 can be used for selectivity
Ground produces damage at the position that user needs.
According to an embodiment of the present, generator 2301 includes a large amount of beneficial aspects.It is real according to one kind of the present invention
Example is applied, when detecting fault condition, such as when following condition, generator 2301 will not start or be treated interrupting：Energy electricity
Cable 2322 is not connected, and one or more coldplate thermocouples 2395 or cooling path thermocouple 2326 are not connected；One
The temperature measured at individual or more coldplate thermocouple 2395 is beyond predetermined limit, such as 45 degrees Celsius；In cooling path
The temperature measured at thermocouple 2326（It can indicate that the temperature of coolant cavity 2360）It is Celsius beyond predetermined limit, such as 45
Degree；There is failure in amplifier 2306；Reflection power exceeds predetermined limit, such as 19.5 watts.A kind of according to the present invention implements
Example, when detect there is fault condition in PWM servo circuits when, such as when following condition, generator 2301 will not start or
Interrupt treatment：The power output of microwave links 2403 is not kept in predetermined window；Set not in 400 ms of instruction
The power output of microwave links 2403；The power output of microwave links 2403 is not kept in preset range, for example, ask power
± 13 watts in；The reflection power and the ratio of forward power measured at directional coupler 2406 exceeds predetermined limit.Root
According to a kind of embodiment of the present invention, when detecting for example following fault condition, generator 2301, which will not start or interrupt, controls
Treat：What the temperature measured at one or more coldplate thermocouples 2395 or cooling path thermocouple 2325 increased or reduced
Speed exceeds predetermined limit；The temperature measured at one or more coldplate thermocouples 2395 or cooling path thermocouple 2325
The speed increase of degree reduces beyond predetermined limit.According to an embodiment of the present, generator 2301 can be transmitted in 40-
Power output in the range of 100 watts.According to an embodiment of the present, generator 2301 can be come with 5 watts of increment
Increase or decrease power output.According to an embodiment of the present, generator 2301 can be kept ± 3 in output power range
The precision of watt.According to an embodiment of the present, generator 2301 can keep 5.8 GHz ± approximate 25 KHz's defeated
Go out frequency.According to an embodiment of the present, cooler 2310 can be by the temperature control of cooling fluid 2361 approximate -5
In the range of to approximate 600 and approximate ± 2.50 degrees centigrade precision.
According to an embodiment of the present, the present invention includes patient's position fixing process.According to one kind of the process of the present invention
Embodiment, can use such as patient's location equipment 2492 that patient is positioned at into supine position.According to the one of the process of the present invention
Embodiment is planted, armpit can be exposed by positioning the arm of patient（For example by the arm that lifts patient and by the hand of patient
It is placed on its lower head）To position patient.According to a kind of embodiment of the process of the present invention, user can recognize or produce trouble
Boundary mark on person's armpit.According to a kind of embodiment of the process of the present invention, such boundary mark can be such as birthmark, spot, scar
Or other personal features.According to the present invention process a kind of embodiment, can by using such as pen, permanent marking device,
Tatoo or the prepared Chinese ink of small sterilization marks to produce such boundary mark.
According to an embodiment of the present, the present invention includes treatment road sign.A kind of according to the process of the present invention implements
Example, once patient is positioned and recognizes or generate appropriate boundary mark, then boundary mark can be used to treat road sign.According to
A kind of embodiment of the present invention, can use the model of such as treatment model 2483 to produce treatment road sign.According to the present invention's
A kind of embodiment of process, treatment model 2483 can be used for the position for recognizing the various road sign elements of therapeutic scheme.According to
A kind of embodiment of the process of the present invention, treatment model 2483 can be used to mark the road sign element in area for treatment, treatment
Region is, for example, the armpit of the various elements with area for treatment.According to a kind of embodiment of the process of the present invention, such member
Part can include for example one or more fix positions 2485 and one or more device position points 2487.Root
According to a kind of embodiment of the process of the present invention, such element can include for example one or more fix positions
2485 and one or more applicators place mark 2489.According to a kind of embodiment of the process of the present invention, such element
For example one or more fix positions 2485 and one or more boundary mark alignment marks 2491 can be included（Can be with
It is alignment mark of for example tatooing）.According to a kind of embodiment of the process of the present invention, outlet mark member can be marked on patient skin
Treatment model 2483 is positioned before the position of part using the boundary mark for identifying or producing in area for treatment.According to the mistake of the present invention
A kind of embodiment of journey, recognizes that the mark of road sign element can be used to guide therapeutic scheme by doctor.
According to a kind of embodiment of the process of the present invention, in some cases, a period, example are there may be between treatment
Such as several weeks, to be enough to need before continual cure area for treatment to provide additional anesthetic.According to one kind of the process of the present invention
Embodiment, when time-event or period be enough to remove or disappear apply previously produced when being used to recognize the mark of road sign element, can
It can be necessary that for example, by so that treatment model 2483 is aligned in the boundary mark for being previously identified or producing and uses treatment model
2483 mark skin to set up these marks again again.According to a kind of embodiment of the process of the present invention, the photograph of area for treatment
Piece can be used to aid in producing or aliging treatment model 2483 so as to subsequent treatment.
According to a kind of embodiment of the process of the present invention, once having treated whole area for treatment, then example can be passed through
The region for needing to modify is treated as needed the dresser in the region modified using only treatment.
According to an embodiment of the present, the present invention includes anaesthesia process.A kind of according to the process of the present invention implements
Example, therapeutic scheme can include at least a portion in anesthesia procedures region.According to a kind of embodiment of the process of the present invention, when controlling
When treatment scheme includes the anesthesia region to be treated, the fix position 2485 on treatment model 2483 can be used for
The position of anesthetic will be injected by recognizing and marking in area for treatment.According to the present invention process a kind of embodiment, suitably
Anesthetic can include lidocaine or with adrenergic lidocaine.According to a kind of embodiment of the process of the present invention,
Anesthetic can be injected into hypodermic layer.According to a kind of embodiment of the process of the present invention, appropriate lidocaine concentrations can
To include 2%, 3%, 4% or 5% lidocaine solution.According to a kind of embodiment of the process of the present invention, appropriate adrenaline
Concentration can include 1 to 100000 solution.According to a kind of embodiment of the process of the present invention, appropriate injection system can be wrapped
Include ring block or penetration mode.According to a kind of embodiment of the process of the present invention, in one kind is treated, with 1:100,000 kidneys
The anesthetic being made up of 2% lidocaine of upper parathyrine concentration can be with skin surface every square centimeter approximate 0.4 in area for treatment
cc（Every three square centimeter of 1.2 cc）Cmax be injected into area for treatment.A kind of according to the process of the present invention implements
Example, for the applicator with the aerial array 2355 including four radiating guides 2364, the appropriate amount of anesthetic can be with
It is the every injection sites of approximate 0.3 cc.According to a kind of embodiment of the process of the present invention, fix position can be located at ripple
Under the center of the hole of lead antenna 2364.According to a kind of embodiment of the process of the present invention, each armpit can be used approximately
10 cc anesthetic.According to a kind of embodiment of the process of the present invention, each armpit can use approximate 20 cc anesthetic.
According to a kind of embodiment of the process of the present invention, the Cmin of anesthetic can be that approximate 0.2 cc is every square centimeter or near
Like 0.15 cc per injection site.According to the present invention process a kind of embodiment, in order to minimize injection Fluid Volume and thus
Minimize the change that dielectric property is organized caused by anesthetic, it might therefore be necessary to utilize specific anesthesia agent concentration, such as band
There is 4% lidocaine of 1 to 100,000 Adrenaline Concentration, the total amount of the anesthetic fluid used can be reduced example by it
Such as half.According to a kind of embodiment of the process of the present invention, use additional anesthetic agent can be so that energy is more evenly distributed in
Destination organization, and the selectivity of energy can be reduced by reducing the energy density in given tissue regions.
According to an embodiment of the present, the present invention includes the process for being properly positioned applicator 2320.According to the present invention
Process a kind of embodiment, therapeutic scheme can also include positioning therapeutic equipment, such as by the disposable device of applicator 2320
2363 are positioned on the area to be treated in area for treatment, and such as tissue cavity 2338 is obtained using such as vacuum acquisition methods
Interior tissue, treats acquired tissue, and pass through for example, by being exposed to the microwave energy from applicator 2320
For example remove vacuum pressure to discharge acquired tissue from tissue cavity 2338.According to a kind of embodiment of the process of the present invention, control
The new treatment region in area for treatment can be then moved to by treating equipment, and repetitive process as needed is until having treated
The area to be treated or its restriction subset.According to an embodiment of the present, when therapeutic equipment is moved to separately from a position
During one position, road sign treatment mark can be used to therapeutic equipment being aligned in not treating on tissue.According to the one of the present invention
Embodiment is planted, road sign treatment mark can also be employed to ensure that the tissue treated with predefined procedure in area for treatment.
According to an embodiment of the present, the present invention includes the process for being used to produce the damage in patient skin.According to
A kind of embodiment of the process of the present invention, for obtaining the tissue effect needed when applying energy, is properly positioned applicator
2320 be probably important.According to a kind of embodiment of the process of the present invention, when applicator 2320 and the quilt of disposable device 2363
When being placed in against skin surface, tissue can be obtained by pulling tissue into tissue cavity 2338.According to the process of the present invention
A kind of embodiment, can realize that tissue is obtained for example, by producing vacuum in the tissue cavity 2338.According to the mistake of the present invention
A kind of embodiment of journey, once being organized in tissue cavity 2338, then microwave energy can be from the distal end radiation of therapeutic equipment to group
In knitting.According to a kind of embodiment of the process of the present invention, at least a portion of the microwave energy of radiation can be with permeate through epidermis and true
Skin, and at least a portion of the microwave energy may reflect off critical interfaces in skin, for example corium-subcutaneous interface or
Interface between corium and gland shape region.According to a kind of embodiment of the process of the present invention, obtained when microwave energy is radiated
In the tissue taken and when being reflected off critical interfaces, standing wave can be produced, this can cause the intradermal in neighbouring critical interfaces
Produce peak value SAR regions.According to a kind of embodiment of the process of the present invention, the tissue in peak value SAR regions will be not dielectrically heated,
So as to which the tissue that destroys or damages in peak value SAR regions and generation for example by conduction or can radiate and be transmitted to surrounding tissue
（Including the tissue below critical interfaces）Heat.According to a kind of embodiment of the process of the present invention, its heat meeting propagated
Destruction damages structure, including for example positioned at the sweat gland or hair follicle propagated in heat path.According to one kind of the process of the present invention
Embodiment, is traveled to produced by directly dielectric heating can increase propagation heat caused by injury tissue by microwave energy
Injury., can be for example, by the temperature at the surface of the acquired tissue of control according to a kind of embodiment of the process of the present invention
To be reduced or eliminated the tissue injury in the epidermis and dermis caused by for example propagating heat.According to the mistake of the present invention
A kind of embodiment of journey, can be for example, by causing cooling fluid 2361 to flow through the applicator in the near surface of acquired tissue
2320 distal end controls the temperature of acquired tissue.According to the present invention process a kind of embodiment, can for example, by
Apply cooling skin surface before microwave energy, cool down skin surface or after microwave energy has been applied when application microwave energy
Temperature at surface of the cooling skin surface to control acquired tissue.
According to a kind of embodiment of the process of the present invention, in many skin types（Include the skin of people, pig and mammal
Skin）This process is effective during the preferable tissue effect of middle generation.According to a kind of embodiment of the process of the present invention, when treatment is removed
Mammal outside people or when treating various disease, illness or area for treatment, can by using remodeling treatment model
Change the process to produce treatment road sign.
According to an embodiment of the present, process of the present invention including the use of the system according to the present invention.According to this hair
A kind of embodiment of bright process, using the system treatment in, various power, the time and chilling temperature setting and algorithm with
And its dependent variable, such as biological barrier construction, acceptable clinical effectiveness can be used to.According to the process of the present invention
A kind of embodiment, unacceptable clinical effectiveness may include serious skin damage.A kind of according to the process of the present invention implements
Example, for treatment patient（Such as human or animal）Epidermis or upper corium should not cause clinically relevant long-term injury.According to
A kind of embodiment of the process of the present invention, serious skin damage can include the serious burn and foaming of skin.According to this hair
A kind of embodiment of bright process, unacceptable clinical effectiveness can include the loss of physical integrity（Infection can be caused
Ulcer or the open sore part）Or the visible scar of epidermis.According to a kind of embodiment of the process of the present invention, unacceptable clinic
As a result the aesthetics change of skin can be included, it can include：The undesirable outward appearance or texture of therapentic part change, and this is
The direct result of applied microwave energy, includes the undesirable permanent aesthetic variation and dermatoglyph of therapentic part color
Undesirable obvious permanent aesthetic variation.According to the present invention process a kind of embodiment, it is occurring during treatment or
The aesthetic variation for needing time solution afterwards may not be undesirable aesthetics change.A kind of according to the process of the present invention implements
Example, what the injury when being treated using the system to fat was desirable to, but it is not up to the degree being harmful to treatment patient.Root
According to a kind of embodiment of the process of the present invention, unacceptable clinical effectiveness can include the injury to big blood vessel and muscle.
According to a kind of embodiment of the process of the present invention, after using the system treatment, when with controlling tissue samples phase
Than when, the apocrine gland under corium/corium of therapentic part in border region（When it is present）What should be showed is abnormal.According to this
A kind of embodiment of the process of invention, using the system treatment after, when with control tissue samples compared with when, therapentic part it is true
Exocrine gland under skin/corium in border region（When it is present）What should be showed is abnormal.According to the one of the process of the present invention
Embodiment is planted, after using the system treatment, gland structure should be changed in structure.According to the one of the process of the present invention
Embodiment is planted, after using the system treatment, the injury for hair follicle is probably desired result, because this contributes to permanently
Ground goes hair removal.
According to a kind of embodiment of the process of the present invention, above the tissue to be treated by the way that applicator 2320 is placed in come
Start treatment.According to a kind of embodiment of the process of the present invention, start pumping by clicking on starting button 2464 to continue to control
Treat.According to a kind of embodiment of the process of the present invention, by obtaining the tissue in chamber 2338 come continual cure.According to the present invention's
A kind of embodiment of process, is bonded in tissue cavity 2338 by causing cooling fluid 2361 by applicator 2320 so as to cool down
Tissue, carry out continual cure.According to a kind of embodiment of the process of the present invention, by continuing to control with scheduled time transimission power
Treat.According to a kind of embodiment of the process of the present invention, by through radiating guide 2364（Include radiating guide in one embodiment
2364a, 2364b, 2364c and 2364d）Circulation microwave energy carrys out continual cure.According to a kind of embodiment of the process of the present invention,
Cooled down by continuation in the cold period after making a reservation for after stopping power transmission one and be bonded on the tissue in tissue cavity to continue to control
Treat.According to a kind of embodiment of the process of the present invention, by discharging the vacuum pressure in tissue cavity 2338 after the cold process after end
Power carrys out continual cure.According to a kind of embodiment of the process of the present invention, by treatment site removal applicator 2320 and once
Property device 2363 carrys out continual cure.According to a kind of embodiment of the process of the present invention, treatment is needed there is additional treatment position
During process, continue to control by step in mobile applicator 2320 to next position and repetition previous steps or more step
Treat.According to a kind of embodiment of the process of the present invention, continual cure is until having treated all plan positions.
According to an embodiment of the present, the present invention includes program elements.A kind of according to the process of the present invention implements
Example, the key element of process can including the use of anesthetic, the energy applied, the cooling applied and the vacuum pressure of administration.
According to the present invention process a kind of embodiment, including for example using anesthetic, apply energy, apply cooling and administration
The program elements of vacuum pressure can be based on patient characteristic（Such as skin thickness）Changed.
According to an embodiment of the present, the present invention includes the mistake for the area for treatment application energy being used for into patient
Journey.According to a kind of embodiment of the process of the present invention, put on tissue energy can according to the power being radiated in tissue and
Depending on the time quantum that power is opened.According to a kind of embodiment of the process of the present invention, being radiated ceiling capacity in tissue can be with
It is the amount of damage energy necessary to without injuring its hetero-organization needed for producing.According to a kind of embodiment of the process of the present invention,
The least energy being radiated in tissue can be the amount of energy necessary to damage needed for producing.According to the one of the process of the present invention
Plant embodiment, tissue effect（Including unwanted tissue effect）It can become with the energy of per unit area.According to the present invention
Process a kind of embodiment, the energy spread apart is more, then tissue effect is smaller.A kind of according to the process of the present invention implements
Example, the ceiling capacity for being transferred to skin can be the energy for causing not extending to intraepidermal damage.According to the process of the present invention
A kind of embodiment, it can be the energy of damage for causing to extend in corium top half to be transferred to the ceiling capacity of skin.
According to a kind of embodiment of the process of the present invention, the ceiling capacity for being transferred to skin can be cause to extend to three on corium/
The energy of damage in two parts.According to a kind of embodiment of the process of the present invention, the power being radiated in tissue can be with defeated
Power and the applicator loss gone out at generator（Including the loss in applicator cable）And become.According to the one of the process of the present invention
Kind of embodiment, applicator loss can be for example approximate 50 percent, the power launched so as to generator 2301 it is only approximate
50/1sts are actually coupled in skin（In preferable or loss-free applicator, the power base in tissue is radiated
This is equal to the power that generator is exported）.According to an embodiment of the present, in the applicator 2320 according to the present invention, damage
Depending on consumption is according to many factors, the factor is, for example, the composition of cooling fluid 2361, the thickness of coolant cavity 2360, coldplate 2340
Composition and the thickness of coldplate 2340.In the system 2309 according to an embodiment of the present invention, the wherein loss of applicator 2320
Approximate 50 percent, then the period that the microwave power that generator radiates 80 watts will be needed to continue 2.5 to 3.5 seconds, so that
Couple the approximate 100 joules intradermals to the tissue of holding in applicator distal end.According to an embodiment of the present, it is desirable that
In the embodiment of the present invention treated with following condition, i.e., when microwave energy with the frequency radiation of approximate 5.8 gigahertz by discharging
Device 2320 and when cooling fluid 2361 is cooled to approximate 15 degree celsius temperature and cycles through coolant cavity 2360, will it is contemplated that
Preferable damage is produced in the armpit of human patientses.According to a kind of embodiment of the process of the present invention, expect such treatment to hinder
Evil or at least sweat gland for damaging human patientses（Such as apocrine gland or exocrine gland）Without the skin outside significantly injury treatment region
Skin.According to an embodiment of the present, using the applicator 2320 with four aerial arrays 2355 and with approximate 20
During the rear cold period of second, 1 × 3 cm area can be treated in approximate 35 seconds.
According to an embodiment of the present, in applicator cable（Can by such as 6 feet long energy cables 2322,
Duplexer 2357 and interconnection cable 2372 are constituted）In the interior system 2309 being lost with 2dB, it is desirable to reach radiating guide
The signal from generator 2301 reduces approximate 37% before 2364.According to an embodiment of the present, in following system 2309
In, i.e., because being input to tissue cavity from radiating guide 2364 caused by such as absorption of cooling fluid 2361 and spurious emissions
The loss of 2338 tissues engaged is 2dB, and the signal of the input now from radiating guide 2364 is in radiating guide 2364
Reduce approximate 37% between input and skin surface.According to an embodiment of the present, applied with 2dB cable losses and 2dB
Device is put into the system 2309 of the loss of tissue, signal power is exported in generator 2301 and is reduced between tissue load approximately
60%.According to an embodiment of the present, in system 2309, the generator 2301 of 80 watts of output will cause approximate 32 watts
Special microwave power is coupled in tissue, and the generator 2301 for exporting 60 watts will cause approximate 24 watts of microwave power
It is coupled in tissue, and exports 55 watts of generator and the microwave power for causing approximate 22 watts is coupled to tissue
It is interior., can be by changing the element in microwave circuit, such as cable cloth in the system 2309 according to an embodiment of the present invention
If, to adjust the power for reaching tissue.
According to an embodiment of the present, the present invention includes application vacuum to obtain the mistake of the tissue in tissue cavity 2338
Journey.According to an embodiment of the present, the vacuum for putting on disposable device 2363 should be sufficient so that skin engagement is being applied
Put in the tissue cavity 2338 of device, to organize to flat against in tissue boundary surface 2336 without injuring tissue.According to the present invention's
A kind of embodiment, for approximate 1 cubic inch（TS）The tissue cavity 2338 of volume and with approximate 3.8 area in square inches
Tissue boundary surface 2336 for, appropriate vacuum pressure can be between approximate 20 to 27 and preferably approximate
20 inches of mercury（Measured at the output of vavuum pump）.According to an embodiment of the present, in order to ensure in energy application
Tissue is obtained before to applicator completely, can be obtained before energy application in a vacuum and vacuum is applied in the period.According to this
A kind of embodiment of invention, the appropriate vacuum acquisition period can be such as two to three seconds.According to an embodiment of the present,
Can be by there is no vacuum sound to notify successfully to obtain come signal in the far-end of applicator 2320.According to one kind of the present invention
Embodiment, can indicate that successful vacuum is obtained by sound or visual signal from generator 2301.According to the present invention
A kind of embodiment, vacuum obtain can further be used on skin produce suction sign, this will be helpful to user's identification
The region being treated.
According to an embodiment of the present, stop in applicator 2320 to after organizing transmission energy, vacuum pressure can
Tissue is maintained at a scheduled time slot in tissue cavity 2338 to be maintained.According to an embodiment of the present, the period
Can cool down the period after for example treating, tissue is held against coldplate in the period and cooling fluid is continued to loop through and applied
Put device.According to an embodiment of the present, the appropriate rear cold period can be between approximate zero to 60 second and preferably
Approximate 20 seconds.According to an embodiment of the present, by be transferred to tissue energy amount to provide appropriate rear cold when
Section.According to an embodiment of the present, when applicator is in the rear cold stage, generator can also produce sound or vision letter
Number, so that applicator is not removed too early.
According to an embodiment of the present, present invention resides in use to transmit anesthesia before micro-wave therapeutic equipment on patient
The process of agent.According to an embodiment of the present, transmission anesthetic can be influenceed on being transferred to determining for tissue how many energy
It is fixed, because anesthetic can absorb some emittance, prevent it from reaching area for treatment.According to an embodiment of the present, though
Such as syringe injection can be so used to transmit anesthetic, but the alternative of transmission anesthetic can include microneedle array
Or iontophoresis device.According to an embodiment of the present, anesthetic can also be injected into oil layer or to hinder
Every treatment region（The armpit of such as human patientses）The mode that interior all nerves are perceived is injected.
According to an embodiment of the present, the present invention includes the method for measurement skin thickness.According to one kind of the present invention
Embodiment, the energy for the tissue effect that the skin thickness in area for treatment can also influence be transmitted to be required
Amount.According to an embodiment of the present, thicker skin may require that more energy correctly to be treated.According to the present invention
A kind of embodiment, a kind of mode for measuring specific region inner skin thickness is to apply microwave energy by skin surface and supervise
The temperature surveyed at skin surface.According to an embodiment of the present, specifically, the increased slope of temperature can indicate that release
Skin thickness below device.According to an embodiment of the present, for example, the short pulse of microwave energy can before treatment tissue
To be used to indicate skin thickness in the skin temperature of the pulse by observed responses, and if skin temperature response is relative
Slowly, then skin temperature response can be used for the energy for changing transmission for example, by the amount of the treatment energy of increase transmission
Amount.
According to an embodiment of the present, the present invention includes treatment model.Implemented performing according to a kind of of the present invention
During example, user can use such as treatment model 2483 to produce road sign.According to an embodiment of the present, example
Such as when treating armpit, user can use the treatment model 2483 for being designed to arm-pit areas.According to the one of the present invention
Kind of embodiment, such model can be selected to be adapted to the armpit of patient, the approx. dimension of armpit, and can be from model
Selected in class library, such as by using the length and width or the hair area alternatively standard of armpit of armpit.According to this hair
A kind of bright embodiment, the appropriate model for armpit can be oval or pyriform.
According to an embodiment of the present, except selecting suitably to treat model 2483 using armpit size and dimension
Outside, the feature of armpit or any area for treatment can be used to selecting appropriate applicator 2320 or for for specific applicator or
Radiating guide 2364 in aerial array selects appropriate starting algorithm.
According to an embodiment of the present, present invention resides in contribute to acquisition group on patient skin using lubricant
The method knitted.According to an embodiment of the present, process, which can be included on skin, uses lubricant（Such as K-Y jellies）
To aid in obtaining.According to an embodiment of the present, process can be drawn into tissue cavity including the use of lubricating to reduce skin
Friction when in 2338.According to an embodiment of the present, process can be balanced around tissue cavity including the use of lubrication
2338 structural power.According to an embodiment of the present, process can aid in ensuring inciting somebody to action including the use of lubricant
The mode that destination organization is properly positioned in tissue cavity 2338 obtains destination organization.According to an embodiment of the present, process
Size and the duration of suction sign can be reduced including the use of lubricant.According to an embodiment of the present, process
Between surface and tissue boundary surface 2336 that skin in tissue cavity 2338 can be reduced including the use of lubricant
The size of air pocket.
According to an embodiment of the present, the present invention includes the treatment to largely characterizing.It is real according to one kind of the present invention
Example is applied, the method for reducing sweat is described.According to an embodiment of the present, describe and reduce what sweat in patient's body was produced
Method.According to an embodiment of the present, the method for describing treatment armpit hidrosis.According to an embodiment of the present,
The method for describing treatment hidrosis.According to an embodiment of the present, the method for describing hair removal.According to the present invention's
A kind of embodiment, describes the method for preventing hair from regrowing.According to an embodiment of the present, treatment underarm odor is described
Method.According to an embodiment of the present, the method that nerve is removed to tissue is described.A kind of according to the present invention implements
Example, the method for describing treatment portwine stain.According to an embodiment of the present, the angiomatous method for the treatment of is described.
According to an embodiment of the present, the psoriasic method for the treatment of is described.According to an embodiment of the present, describe and subtract
The method of hypohidrosis liquid.According to an embodiment of the present, the method for reducing sweat is described.A kind of according to the present invention implements
Example, electromagnetic energy be used to treat acne.According to an embodiment of the present, the method for describing treatment sebaceous glands.According to
A kind of embodiment of the present invention, the method for describing eliminating bacteria.According to an embodiment of the present, elimination propionic acid is described
The method of bacterium.According to an embodiment of the present, the method for describing treatment inflammation.
According to an embodiment of the present, electromagnetic energy can be used to reduce sweat.It is real according to one kind of the present invention
Example is applied, the sweat that electromagnetic energy can be used to reduce in patient's body is produced.According to an embodiment of the present, electromagnetic energy
It can be used to treat armpit hidrosis.According to an embodiment of the present, electromagnetic energy can be used to treat hidrosis.According to
A kind of embodiment of the present invention, electromagnetic energy can be used to remove hair.According to an embodiment of the present, electromagnetic energy
It can be used to prevent hair regeneration.According to an embodiment of the present, electromagnetic energy can be used to treat underarm odor.According to
A kind of embodiment of the present invention, electromagnetic energy can be used for cutting tissue nerve.According to an embodiment of the present, it is electric
Magnetic energy can be used to treat portwine stain.According to an embodiment of the present, electromagnetic energy can be used for treatment
Hemangioma.According to an embodiment of the present, electromagnetic energy can be used to treat psoriasis.It is real according to one kind of the present invention
Example is applied, electromagnetic energy can be used to reduce sweat.In an embodiment of the present invention, electromagnetic energy can be used to treat Cuo
Sore.In an embodiment of the present invention, electromagnetic energy can be used to treat sebaceous glands.In an embodiment of the present invention, electromagnetic energy
Amount can be used for eliminating bacteria.In an embodiment of the present invention, electromagnetic energy can be used to eliminate bacterium acidi propionici.In the present invention
Embodiment in, electromagnetic energy can be used for from hair follicle clear up scaling fat.In an embodiment of the present invention, electromagnetic energy can be with
It is used for the hair follicle that cleaning is blocked.In an embodiment of the present invention, electromagnetic energy can be used to eliminate blackhead.In this hair
In bright embodiment, electromagnetic energy can be used to clear up blackhead.In an embodiment of the present invention, electromagnetic energy can be used for
Clear up miliaria.In an embodiment of the present invention, electromagnetic energy can be used to reduce inflammation.In an embodiment of the present invention,
Electromagnetic energy can be used for burn fat.In an embodiment of the present invention, electromagnetic energy can be used to reduce cellulite.
According to an embodiment of the present, the disposable medical equipment of description includes：Positioned at Disposable artifact distal end
Tissue cavity；Positioned at the applicator chamber of Disposable artifact near-end；Separate tissue cavity and applicator interface（Interface）Tissue biological's screen
Barrier；And the vacuum loop of connection tissue cavity and applicator chamber.According to an embodiment of the present, tissue cavity can include：
Tissue boundary surface, tissue boundary surface includes：Around the vacuum passage of tissue biological's barrier；With vacuum passage and vacuum loop
The vacuum ports being in fluid communication；And around the cavity wall of tissue cavity.According to an embodiment of the present, cavity wall also includes softness
Component.According to an embodiment of the present, compliant member has the height between approximate 0.15 inch to approximate 0.25 inch
Degree.According to an embodiment of the present, compliant member has approximate 0.25 inch of height.A kind of according to the present invention implements
Example, cavity wall also includes at least one of lubricant for being coated with cavity wall.According to an embodiment of the present, lubricant is selected from
By silicone oil, Teflon, Parylene or the group for being easy to other the appropriate coating materials for obtaining tissue to constitute.According to one kind of the present invention
Embodiment, applicator chamber includes：Applicator interface surface, wherein applicator interface surface surround tissue biological's barrier；Around applying
Put the applicator interface wall of device interface surface；And the vacuum seal in the proximal end of applicator chamber, vacuum seal determined
Position hermetically seals applicator chamber into when applicator is located at applicator intracavitary.According to an embodiment of the present, applicator
The depth that chamber has is enough to receive and engages applicator so as to the distal contact tissue biological barrier of applicator, so as in applicator
Distal end and tissue biological's barrier between produce interference engagement.According to an embodiment of the present, the depth that applicator chamber has
Degree is enough to ensure that the applicator positioned at applicator intracavitary makes biological barrier move in tissue cavity approximate 0.001 inch to approximate
Between 0.030 inch.According to an embodiment of the present, the depth that applicator chamber has is enough to ensure that positioned at applicator intracavitary
Applicator biological barrier is moved in tissue cavity approximate 0.010 inch.According to an embodiment of the present, applicator chamber
The depth having is enough to receive and engages applicator so as to the distal contact tissue biological barrier of applicator, so that when assembling is located at
When in tissue cavity interference engagement is produced between the distal end of applicator and tissue biological's barrier.A kind of according to the present invention implements
Example, tissue biological's barrier is flexible.According to an embodiment of the present, tissue biological's barrier is film.According to the present invention's
A kind of embodiment, tissue biological's barrier has the thickness between 0.0001 inch to approximate 0.030 inch.According to the present invention's
A kind of embodiment, tissue biological's barrier has approximate 0.0005 inch of thickness.According to an embodiment of the present, vacuum is returned
Road includes：Main vacuum passage, main vacuum passage is in fluid communication with applicator chamber；It is in fluid communication with main vacuum passage and tissue cavity
Vacuum ports.According to an embodiment of the present, vacuum loop also includes：Connect with the vacuum that main vacuum passage is in fluid communication
Connect device；Applicator biological barrier between main vacuum passage and applicator chamber.According to an embodiment of the present, discharge
Device biological barrier is located at the first side of disposable medical equipment, and vacuum coupling is located at the second of disposable medical equipment
Side.According to an embodiment of the present, main vacuum passage is included in circuitous between vacuum coupling and applicator biological barrier
Loop footpath.According to an embodiment of the present, main vacuum passage also includes being located at the vacuum gear near applicator biological barrier
Plate.According to an embodiment of the present, the main vacuum passage between vacuum ports contact vacuum coupling and vacuum barrier.
According to an embodiment of the present, the present invention includes the method for the vacuum pressure in balance medical treatment device, wherein
Medical treatment device includes applicator and disposable device, and the disposable device includes the tissue separated by flexible tissue biological barrier
Chamber and applicator chamber, methods described comprise the following steps：Applicator is placed on into applicator intracavitary to discharge so that applicator is sealed
Device chamber opening；Tissue is placed near tissue cavity to organize seal tissue chamber opening at least in part；From tissue cavity's suction
Air；And aspirate air from applicator chamber.According to an embodiment of the present, the vacuum pressure in balance medical treatment device
Method, this method also comprises the following steps：Applicator is placed on distal end and tissue biological of the applicator intracavitary so as to applicator
Barrier formation interference engagement.According to an embodiment of the present, the method for the vacuum pressure in balance medical treatment device also includes
Following steps：Applicator is placed on applicator intracavitary so as to the distal end of applicator tissue biological's barrier is stretched to tissue cavity
It is interior.According to an embodiment of the present, the method for the vacuum pressure in balance medical treatment device also comprises the following steps：By tissue
Biological barrier is stretched in tissue cavity the distance between approximate 0.001 inch to approximate 0.030 inch.According to one kind of the present invention
The method of vacuum pressure in embodiment, balance medical treatment device also comprises the following steps：Tissue biological's barrier is stretched to tissue
The distance that approximate 0.010 inch of intracavitary.According to an embodiment of the present, the side of the vacuum pressure in balance medical treatment device
Method, wherein the step of the step of aspirating air from applicator chamber includes aspirating air by biological barrier.
According to an embodiment of the present, the area of the skin histology using medical treatment device below the first area of corium
The method that damage is produced in domain, wherein the medical treatment device includes applicator and disposable device, the applicator includes cooling
Plate, the disposable device includes tissue cavity and the applicator chamber separated by flexible tissue biological barrier, and methods described includes as follows
Step：Applicator is placed on applicator intracavitary so that applicator seals applicator chamber opening；Skin histology is placed on tissue
Chamber is nearby to organize seal tissue chamber opening at least in part；Air is aspirated from tissue cavity；From applicator chamber aspirate air with
Just applicator intracavitary is pulled tissue into；Propagate electromagnetic energy and pass through coldplate and tissue biological's barrier.According to one kind of the present invention
The method of vacuum pressure in embodiment, balance medical treatment device, this method also comprises the following steps：Applicator is placed on release
Distal end and tissue biological barrier formation interference engagement of the device intracavitary so as to applicator.According to an embodiment of the present, balance
The method of vacuum pressure in medical treatment device, this method also comprises the following steps：By applicator be placed on applicator intracavitary so as to
Tissue biological's barrier is stretched in tissue cavity by the distal end of applicator.According to an embodiment of the present, medical treatment device is balanced
The method of interior vacuum pressure also comprises the following steps：Tissue biological's barrier is stretched in tissue cavity approximate 0.001 inch extremely
The distance between approximate 0.030 inch.According to an embodiment of the present, the method for the vacuum pressure in balance medical treatment device
Also comprise the following steps：Tissue biological's barrier is stretched to approximate 0.010 inch in tissue cavity of distance.According to the one of the present invention
The method for planting the vacuum pressure in embodiment, balance medical treatment device also comprises the following steps：Applicator is placed on applicator chamber
Interior distal end and tissue biological's barrier formation interference engagement so as to applicator.According to an embodiment of the present, medical treatment is balanced
The method of vacuum pressure in device, wherein the step of aspirating air from applicator chamber including passing through biological barrier aspirates air
Step.
According to an embodiment of the present, energy transmission applicator is described, it includes：In applicator distal end once
Property interface, the disposable interface include disposable engaging mechanism；Antenna structure, it includes being configured to the distal end by applicator
Propagate at least one antenna hole of energy；And at least a portion of the cooling circuit including coldplate, wherein cooling circuit
It is placed between antenna and the distal end of applicator.According to an embodiment of the present, the antenna includes：Multiple antennas；If
It is set to the distribution member to multiple antenna propagation energy.According to an embodiment of the present, distribution member includes microwave switch.
According to an embodiment of the present, distribution member includes power divider.According to an embodiment of the present, energy transmission
Applicator also includes the dispersing element being located between hole and applicator distal end.According to an embodiment of the present, cool back
Road also includes the cooling chamber being located between antenna hole and the proximal lateral of coldplate.According to an embodiment of the present, cool down
At least a portion in loop is located between antenna and the distal end of applicator.According to an embodiment of the present, waveguide assemblies bag
Include：Multiple radiating guides in antenna holder；It is arranged to the distribution member to multiple antenna propagation energy.According to the present invention
A kind of embodiment, distribution member include microwave switch.According to an embodiment of the present, distribution member includes power distribution
Device.According to an embodiment of the present, energy transmission applicator is also included positioned at multiple between hole and applicator distal end
Dispersing element.According to an embodiment of the present, cooling circuit also include positioned at the proximal lateral of antenna hole and coldplate it
Between cooling chamber.According to an embodiment of the present, waveguide assemblies include：Multiple radiating guides in antenna holder；
It is arranged to the distribution member to multiple antenna propagation energy.According to an embodiment of the present, cooling circuit is additionally included in day
Cooling channel in line bracket, cooling channel is connected to cooling chamber.According to an embodiment of the present, waveguide assemblies include：
Multiple radiating guides；And multiple isolation elements between antenna.According to an embodiment of the present, waveguide assemblies are also
The second isolation member including the first isolation element at the first end of waveguide assemblies and at the second end of waveguide assemblies
Part.According to an embodiment of the present, isolation element includes the pad of microwave absorbing material.A kind of according to the present invention implements
Example, isolation element includes microwave choke.According to an embodiment of the present, radiating guide includes：Internal dielectric piece；Except
The shell of all gussets outside hole around internal dielectric piece.According to an embodiment of the present, coldplate includes：Near-end table
Face；Distal surface；One or more thermocouple grooves in distal surface；And one in thermocouple groove or
More thermocouples.According to an embodiment of the present, thermocouple groove is disposed parallel to when the energy propagated is micro-
The E- fields launched during wave energy by waveguide assemblies.According to an embodiment of the present, microwave energy is transmitted with TE10 patterns.
According to an embodiment of the present, the method using energy transmission applicator cools tissue, the energy are described
Propagating applicator includes antenna hole and coldplate, and the coldplate has proximal end face and distal surface and is placed in energy biography
The distal end of applicator is broadcast, and antenna hole is adjacent to coldplate and is placed in energy transmission applicator, and this method includes as follows
Step：So that tissue is bonded in the energy transmission applicator near coldplate；Apply energy to tissue, the energy passes through cooling
Plate；And cooling fluid is passed through between antenna hole and the proximal end face of coldplate.
According to an embodiment of the present, the method to tissue distribution electromagnetic energy is described, this method includes as follows
Step：From antenna hole emittance；Emittance flows through the cooling below hole by cooling fluid, wherein cooling fluid
Chamber；Emittance passes through the dispersing element being located in cooling chamber；Emittance passes through the coldplate positioned at hole opposite；Radiation energy
Tissue biological's barrier that amount passes through coldplate distal side.
According to an embodiment of the present, the method to aerial array supplying energy is described, this method includes as follows
Step：Electromagnetic energy is supplied to the switch in applicator, the wherein switch is connected to one or more radiating guides；
By switching to first wave guide antenna provision electromagnetic energy in scheduled time slot；By switching to second waveguide day in scheduled time slot
Line supplies electromagnetic energy without repositioning applicator.According to an embodiment of the present, to aerial array supplying energy
Method, wherein the first and second radiating guides are adjacent to each other.According to an embodiment of the present, describe and supplied to aerial array
The method that should be able to be measured, this method comprises the following steps：Electromagnetic energy, wherein power are supplied to the applicator including power divider
Distributor is connected to one or more radiating guides；Power divider is continuously attached to one or more ripple
At least two in lead antenna；Do not reposition applicator；The energy supply to individual antenna is kept in scheduled time slot.
According to an embodiment of the present, the microwave links control electricity used in medical treatment device microwave generator is described
Road, the control circuit includes：It is coupled to the directional coupler of the output of microwave links；It is coupled to the power detection of directional coupler
Device, the power detector includes forward power detector and reverse power detector, and power detector includes attenuator and detection
Device diode；The forward power look-up table of forward power detector is coupled to, the forward lookup table includes detecting with forward power
The associated data of the feature of device；The reverse power look-up table of reverse power detector is coupled to, the reverse power look-up table bag
Include the data associated with the feature of reverse power detector；The duty factor circuit of forward power look-up table is coupled to, wherein
The duty factor circuit is coupled to the switch in microwave links, and the switch is suitable to the input signal of the amplifier in control microwave links
Duty factor.
According to an embodiment of the present, the defeated of microwave links of the control in medical treatment device microwave generator is described
Go out the method for power, this method comprises the following steps：Detect the forward power signal at the output of microwave links；Forward power is believed
Number it is fed in forward power look-up table, the forward power look-up table includes the correlation of the electrical feature based on forward power detector
Data；According to relevant data modifications forward power signal；Amended forward power signal is fed to duty factor circuit, its
In the duty factor circuit be suitable to control microwave links in amplifier input signal duty factor.
According to an embodiment of the present, patient support apparatus is described, it includes：Center support；It is pre- with first
The first and second arm support members that angle is connected to core are determined, wherein first predetermined angle is at approximate 15 degree to approximate three
Between 15 degree.According to an embodiment of the present, the first predetermined angle is approximate 25 degree.
According to an embodiment of the present, treatment model is described, it includes：Flexible and transparent substrate, the flexible and transparent
Substrate includes：It is printed on one or more area for treatment profiles in substrate；It is printed on multiple equidistant anesthetic in substrate
Injection site；It is printed on multiple models positioning sign in substrate；The multiple applicators being printed in substrate place sign.
According to an embodiment of the present, the method for describing hidrosis in treatment patient's body, it includes：Patient is placed
On patient support apparatus；The boundary mark that model is aligned on patient's armpit will be treated；Anesthetic note is marked on patient's armpit
Penetrate position；Applicator position point is marked on patient's armpit；So that applicator is aligned in applicator position point；To patient
Armpit applies cooling；Energy is applied to patient's armpit；Energy conversion is set to pass through multiple antennas in applicator；Remove applicator simultaneously
And applicator is moved to the second therapentic part using alignment mark.
It is described above to be looked at as only being the description to the principle of the invention.In addition, because those skilled in the art can be easy
A large amount of variations and modifications are recognized on ground, it is not desired that limiting the invention to shown and described precision architecture and operation.Though
Preferred embodiment so has been described, but can change thin in the case of without departing substantially from the present invention defined by the claims
Section.
Claims (17)
1. a kind of energy transmission system, including：
Energy transmission applicator（2320）；
Disposable interface positioned at the applicator distal end, the disposable interface includes：
Positioned at the disposable interface（2363）Distal end tissue cavity（2338）, the tissue cavity（2338）Including remote positioned at its
The compliant member at end（2375）, the compliant member（2375）It is positioned at tissue cavity（2338）Outward flange around to provide skin
With the tissue cavity（2338）Between sealing；
Positioned at the disposable interface（2363）Near-end applicator chamber（2346）；
Connect the tissue cavity（2338）With the applicator chamber（2346）Vacuum loop（2341）, the vacuum loop
（2341）It is connected to vacuum pressure source；
Form tissue biological's barrier（2337）Flexible membrane, tissue biological's barrier（2337）By the tissue cavity（2338）With
The applicator chamber（2346）Separate, tissue biological's barrier（2337）It is the dielectric material of microwaves energy；
Form applicator biological barrier（2332）Film filter, the applicator biological barrier（2332）Positioned at the tissue cavity
（2338）With the applicator chamber（2346）Between vacuum loop（2341）In, with balanced tissue cavity（2338）With applicator chamber
（2346）In vacuum pressure；And
Positioned at the applicator chamber（2346）Near-end vacuum seal（2348）, work as applicator（2320）Discharged positioned at described
Device chamber（2346）When middle, the vacuum seal（2348）It is oriented to seal the applicator chamber（2346）,
Antenna structure（2364）, it includes being configured at least one day that energy is propagated by the distal end of the applicator
String holes gap, and
Including coldplate（2340）Cooling circuit（2376）, wherein at least a portion of the cooling circuit is placed in the day
Between line and the distal end of the applicator.
2. energy transmission system according to claim 1, wherein the antenna includes：
Multiple antennas；
It is configured to the distribution member to energy described in the multiple antenna propagation（2357）.
3. energy transmission system according to claim 2, wherein the distribution member includes microwave switch（2357）.
4. energy transmission system according to claim 2, wherein the distribution member includes power divider（2357）.
5. energy transmission system according to claim 1, wherein the energy transmission applicator also includes：
Dispersing element between the hole and the distal end of the applicator（2378）.
6. energy transmission system according to claim 1, wherein the cooling circuit also includes:
Cooling chamber between the antenna hole and the proximal lateral of the coldplate（2360）.
7. energy transmission system according to claim 1, wherein the antenna structure includes waveguide assemblies（2358）, it is described
Waveguide assemblies include being configured to multiple antenna holes that energy is propagated by the distal end of the applicator.
8. energy transmission system according to claim 7, wherein the waveguide assemblies include：
Positioned at antenna holder（2374）Interior multiple radiating guides（2364）；
It is configured to the distribution member to energy described in the multiple antenna propagation.
9. energy transmission system according to claim 8, wherein the distribution member includes microwave switch.
10. energy transmission system according to claim 8, wherein the distribution member includes power divider.
11. energy transmission system according to claim 7, wherein the energy transmission applicator also includes：
Multiple dispersing elements between the hole and the distal end of the applicator.
12. energy transmission system according to claim 7, wherein the cooling circuit also includes being located at the antenna hole
Cooling chamber between the proximal lateral of the coldplate.
13. energy transmission system according to claim 12, wherein the waveguide assemblies include：
Multiple radiating guides in antenna holder；
It is configured to the distribution member to energy described in the multiple antenna propagation.
14. energy transmission system according to claim 13, wherein the cooling circuit is additionally included in the antenna holder
Interior cooling channel, the cooling channel is connected to the cooling chamber.
15. energy transmission system according to claim 7, wherein the coldplate includes：
Proximal end face；
Distal surface；
One or more thermocouple grooves in the distal surface；And
One or more thermocouples in the thermocouple groove.
16. energy transmission system according to claim 15, wherein the thermocouple groove is disposed parallel to work as institute
The E- fields launched when the energy for stating propagation is microwave energy by the waveguide assemblies.
17. energy transmission system according to claim 16, wherein the microwave energy is with TE10Pattern is transmitted.
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1327407P | 2007-12-12 | 2007-12-12 | |
| US61/013274 | 2007-12-12 | ||
| US4593708P | 2008-04-17 | 2008-04-17 | |
| US61/045937 | 2008-04-17 | ||
| USPCT/US08/60935 | 2008-04-18 | ||
| USPCT/US08/60929 | 2008-04-18 | ||
| PCT/US2008/060922 WO2009075903A1 (en) | 2007-04-19 | 2008-04-18 | Systems and methods for creating an effect using microwave energy to specified tissue |
| PCT/US2008/060935 WO2008131302A2 (en) | 2007-04-19 | 2008-04-18 | Methods and apparatus for reducing sweat production |
| PCT/US2008/060929 WO2009075904A1 (en) | 2007-04-19 | 2008-04-18 | Methods, devices, and systems for non-invasive delivery of microwave therapy |
| USPCT/US08/60922 | 2008-04-18 | ||
| PCT/US2008/060940 WO2008131306A1 (en) | 2007-04-19 | 2008-04-18 | Systems and methods for creating an effect using microwave energy to specified tissue |
| USPCT/US08/60940 | 2008-04-18 | ||
| US12/107,025 US9427285B2 (en) | 2007-04-19 | 2008-04-21 | Systems and methods for creating an effect using microwave energy to specified tissue |
| US12/107025 | 2008-04-21 | ||
| US19694808P | 2008-10-22 | 2008-10-22 | |
| US61/196948 | 2008-10-22 | ||
| CN200880126637.8A CN101970046B (en) | 2007-12-12 | 2008-12-12 | Disposable medical equipment and system thereof |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880126637.8A Division CN101970046B (en) | 2007-12-12 | 2008-12-12 | Disposable medical equipment and system thereof |
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| CN104707263A CN104707263A (en) | 2015-06-17 |
| CN104707263B true CN104707263B (en) | 2017-09-12 |
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| EP3347091B1 (en) * | 2015-09-09 | 2020-06-17 | CPG Technologies, LLC. | Power internal medical devices with guided surface waves |
| CN106821493B (en) * | 2017-03-24 | 2024-02-27 | 深圳半岛医疗集团股份有限公司 | Microneedle therapy head and microneedle therapy apparatus |
| US20210068795A1 (en) * | 2017-08-31 | 2021-03-11 | Smith & Nephew, Inc. | Computer-controlled remote power module |
| CN109793568B (en) * | 2019-01-30 | 2020-12-01 | 苏州信迈医疗器械有限公司 | Multi-electrode ablation device |
| CN112244993B (en) * | 2020-10-31 | 2022-03-15 | 杭州诺生医疗科技有限公司 | Radio frequency ablation instrument |
Citations (2)
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| CN1688363A (en) * | 2002-10-10 | 2005-10-26 | 麦科罗苏立思有限公司 | Microwave applicator |
| CN1781462A (en) * | 2004-11-23 | 2006-06-07 | 里泰克有限公司 | Tissue resurfacing |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4197860A (en) * | 1977-11-21 | 1980-04-15 | Rca Corporation | Hyperthermia applicator |
| JPS62149347U (en) * | 1986-03-13 | 1987-09-21 | ||
| BR9305925A (en) * | 1992-02-20 | 1997-08-26 | Humanteknik Ab | Device for vacuum affixing an object to a surface electrode unit and absorber for a vacuum electrode assembly |
| EP0597463A3 (en) * | 1992-11-13 | 1996-11-06 | Dornier Med Systems Inc | Thermotherapiesonde. |
| US6104959A (en) * | 1997-07-31 | 2000-08-15 | Microwave Medical Corp. | Method and apparatus for treating subcutaneous histological features |
| US20030181890A1 (en) * | 2002-03-22 | 2003-09-25 | Schulze Dale R. | Medical device that removably attaches to a bodily organ |
| JP2008501444A (en) * | 2004-06-07 | 2008-01-24 | エドワーズ ライフサイエンシーズ コーポレイション | Method and device for directional resection of tissue |
| JP2006289098A (en) * | 2005-04-12 | 2006-10-26 | Inolase 2002 Ltd | Apparatus for vacuum-assisted light-based treatment of skin |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1688363A (en) * | 2002-10-10 | 2005-10-26 | 麦科罗苏立思有限公司 | Microwave applicator |
| CN1781462A (en) * | 2004-11-23 | 2006-06-07 | 里泰克有限公司 | Tissue resurfacing |
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| JP2018140185A (en) | 2018-09-13 |
| CN104707263A (en) | 2015-06-17 |
| SG186642A1 (en) | 2013-01-30 |
| JP6320470B2 (en) | 2018-05-09 |
| JP2014184317A (en) | 2014-10-02 |
| JP2016185400A (en) | 2016-10-27 |
| JP5978245B2 (en) | 2016-08-24 |
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