CN104690961A - Biological 3D printing apparatus - Google Patents
Biological 3D printing apparatus Download PDFInfo
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- CN104690961A CN104690961A CN201310658657.2A CN201310658657A CN104690961A CN 104690961 A CN104690961 A CN 104690961A CN 201310658657 A CN201310658657 A CN 201310658657A CN 104690961 A CN104690961 A CN 104690961A
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Abstract
The present invention relates to a biological 3D printing apparatus, which comprises a printing platform, a three-axis motion mechanism, a wire extruding mechanism, spraying heads and a thermal insulation mechanism, wherein the three-axis motion mechanism and the printing platform are respectively arranged on the chassis of the printing apparatus, the wire extruding mechanism and the three-axis motion mechanism are connected, the spraying head is arranged on the wire extruding mechanism, is downward and points to the printing platform, and the thermal insulation mechanism is arranged on the printing platform. According to the present invention, the spraying head is easy to disassemble and assemble, and different spraying heads can be selectively arranged according to different printing materials; the printing platform has the thermal insulation function and further has functions of heating and cooling so as to meet the printing requirements of the high-temperature material and the low-temperature material; and the biological material or living cells can be assembled in a positioning manner, artificial implantation stents, tissues and organs, medical auxiliary tools and other biomedical products can be manufactured, the use is flexible, and the use range is wide.
Description
Technical field
The present invention relates to a kind of printing device, particularly relate to a kind of biological 3D printing equipment.
Background technology
3D printing technique is one by the rapid shaping technique of any complicated shape three dimensional physical of quick manufacture entity of digital model Direct driver, the manufacture thought that its general principle all adopts " Layered manufacturing, successively superpose ".It can computer, laser, the modern means such as precision drive and numerical control, CAD and computer-aided manufacturing are integrated in one, according to the threedimensional model constructed on computers, directly outturn sample can be produced within very short time, mechanical processing machine that need not be traditional and mould, have the plurality of advantages such as cost is low, the cycle is short, amendment is simple, dimensionally stable.But current 3D printer, by the restriction of structure and material, generally all can only print metal or alloy material, substantially be used in field of machining and machinebuilding technology, cannot realize the printing of biomaterial, there is limitation in the scope of application.
Summary of the invention
The present invention mainly solves original 3D printer generally all can only print metal or alloy material, and be substantially used in field of machining and machinebuilding technology, cannot realize the printing of biomaterial, the scope of application exists circumscribed technical problem; There is provided a kind of biological 3D printing equipment, it can print biomaterial, and printing according to difference needs replaceable different shower nozzle, and use flexibly, the scope of application is extensive.
Above-mentioned technical problem of the present invention is mainly solved by following technical proposals: the present invention includes print platform, three-axis moving mechanism, wire squeeze mechanism, shower nozzle and heat preservation mechanism, three-axis moving mechanism and print platform are arranged on the chassis of printing equipment respectively, wire squeeze mechanism is connected with three-axis moving mechanism, described shower nozzle is arranged in described wire squeeze mechanism, and shower nozzle points to described print platform down, heat preservation mechanism is located on described print platform.Three-axis moving mechanism can drive shower nozzle to do the movement of X to, Y-direction and Z-direction three directions, biomaterial can be sprayed onto smoothly print platform in shower nozzle thus complete print out task on request by the biomaterial in extruding jet by wire squeeze mechanism.Heat preservation mechanism plays insulation effect to print platform and the biomaterial printed on print platform, and can heat according to the needs of printed biomaterial and also can freeze, minimum temperature can reach 0 DEG C.The printable multiple biomaterial of the present invention, as: hydroxyapatite, titanium , tricalcium phosphate carbon etc. are for the material of bore regenerating, polycaprolactone, PLA, poly lactic coglycolic acid etc. are for the material of medicine controlled releasing, agar, poly glucosamine, alginate, gelatin, ossein, cellulose etc. are for the material of soft tissue biological structure and Organ printing, and polyurethane, silicone etc. are for the material of conceptual model.The present invention can orientation assemble biomaterial or living cells, the biomedical products such as manufacture of intraocular implant frame, histoorgan and medical auxiliary tool, and use flexibly, the scope of application is extensive.
As preferably, the piston that described wire squeeze mechanism is comprised installing rack, is located at the pushing block by Electric Machine Control on installing rack and is connected by connecting rod with pushing block, described shower nozzle is arranged on the bottom of installing rack, and described piston is located in described shower nozzle.Motor forward or reverse, drive pushing block to rise or decline, pushing block drives piston to rise by connecting rod or declines, when piston declines, extrude the biomaterial installed additional in the showerhead, make biomaterial flow out from shower nozzle and be sprayed onto on print platform along with the movement of shower nozzle, thus the 3D completing biomaterial print.
As preferably, described shower nozzle is high temp. jetting nozzle or low temperature shower nozzle.Shower nozzle is arranged in wire squeeze mechanism removably, as adopted interface arrangment or being fixedly connected with by screw.Can choice for use high temp. jetting nozzle or low temperature shower nozzle according to different biomaterials, then keep shower nozzle to maintain design temperature by temperature control system.High temp. jetting nozzle can adopt heating rod to heat, and low temperature shower nozzle can adopt and realize refrigeration at its peripheral runner being connected with cooling fluid that arranges.High temp. jetting nozzle print temperature is at 60 ~ 260 DEG C, and low temperature shower nozzle print temperature is at 0 ~ 60 DEG C.Meet the needs of different biomaterial, use flexibly, the scope of application is extensive.
As preferably, described heat preservation mechanism comprises heat exchange coil, and the surrounding of described print platform is provided with coaming plate, and left side, right side and the coaming plate of rear side and the back side of print platform are equipped with heat exchange coil, have hot fluid or cooling fluid in heat exchange coil, heat exchange coil is connected with heat exchanger.When printing high-temperature material, be hot fluid in heat exchange coil, print platform is heated; When printing cryogenic material, be cooling fluid in heat exchange coil, print platform is freezed.Certainly, also by infrared ray, laser or microwave etc., print platform is heated.
As preferably, the coaming plate on front side of described print platform is block transparent panel.By transparent panel, print path and the lamination process of biomaterial can be seen clearly.
As preferably, described three-axis moving mechanism comprises Y-direction motion, X to motion and Z-direction motion, Y-direction motion is located at left side and the right side on the chassis of printing equipment, Y-direction motion is provided with a vertically disposed platform, X is located at table top to motion, X is provided with a back-up block on motion, and described Z-direction motion is located on described back-up block, and described wire squeeze mechanism is arranged on Z-direction motion.Y-direction motion, X can adopt guide rail leading screw to realize to motion and Z-direction motion.Vertically disposed platform moves as Y-direction, and gripper shoe makes X to movement, and wire squeeze mechanism moves as Z-direction, thus drives shower nozzle to complete three-axis moving.Structure is simple, and reliability is high.
The invention has the beneficial effects as follows: shower nozzle easy accessibility, can select different shower nozzles is installed according to different printed material, print platform has heat insulation function, both can heat and also can freeze, meet the printing requirement of high-temperature material and cryogenic material, can orientation assemble biomaterial or living cells, the biomedical products such as manufacture of intraocular implant frame, histoorgan and medical auxiliary tool, use flexibly, the scope of application is extensive.
Accompanying drawing explanation
Fig. 1 is a kind of perspective view of the present invention.
Fig. 2 is a kind of perspective view of print platform and coaming plate in the present invention.
Fig. 3 is the main TV structure schematic diagram of the one of coaming plate in the present invention.
Fig. 4 is the main TV structure schematic diagram of one of wire squeeze mechanism in the present invention.
1. print platforms in figure, 2. wire squeeze mechanism, 3. shower nozzle, 4. installing rack, 5. motor, 6. pushing block, 7. connecting rod, 8. heat exchange coil, 9. transparent panel, 10.Y direction guiding rail, 11.X direction guiding rail, 12.Z direction guiding rail, 13. chassis, 14. platforms, 15. back-up blocks, 16. coaming plates.
Detailed description of the invention
Below by embodiment, and by reference to the accompanying drawings, technical scheme of the present invention is described in further detail.
Embodiment: the biological 3D printing equipment of one of the present embodiment, as shown in Figure 1, comprises print platform 1, three-axis moving mechanism, wire squeeze mechanism 2, shower nozzle 3 and heat preservation mechanism.Three-axis moving mechanism and print platform 1 are arranged on the chassis 13 of printing equipment respectively, three-axis moving mechanism comprises Y-direction motion 10, X to motion 11 and Z-direction motion 12, Y-direction motion is arranged on left side and the right side on the chassis 13 of printing equipment, Y-direction motion 10 is provided with a vertically disposed platform 14, X is arranged on platform 14 top to motion 11, X is provided with a back-up block 15 on motion 11, Z-direction motion 12 is arranged on back-up block 15, and wire squeeze mechanism 2 is arranged on Z-direction motion 12.As shown in Figure 4, the piston that wire squeeze mechanism 2 is comprised installing rack 4, is installed on the pushing block 6 by motor 5 control on installing rack 4 and is connected by connecting rod 7 with pushing block 6, installing rack 4 is arranged on Z-direction motion 12, shower nozzle 3 is arranged on the bottom of installing rack 4, piston is arranged in shower nozzle 3, and shower nozzle 3 points to print platform 1 down.Shower nozzle 3 adopts Demountable, can choice for use high temp. jetting nozzle or low temperature shower nozzle according to the needs of printed material, and high temp. jetting nozzle heats by heating rod, and low temperature shower nozzle realizes refrigeration by the peripheral runner being connected with cooling fluid that arranges.High temp. jetting nozzle print temperature is at 60 ~ 260 DEG C, low temperature shower nozzle print temperature is at 0 ~ 60 DEG C, heat preservation mechanism is arranged on print platform 1, as Fig. 2, shown in Fig. 3, heat preservation mechanism comprises heat exchange coil 8, the surrounding of print platform 1 respectively has one block of coaming plate 16, the coaming plate of front side is block transparent panel 9, left side, right side and the coaming plate of rear side and the back side of print platform are all provided with heat exchange coil 8, in heat exchange coil 8, stream has heat-exchange carrier, when needing heating, it is hot fluid in heat exchange coil, when needing refrigeration, it is cooling fluid in heat exchange coil, the import of heat exchange coil 8, outlet is connected with heat exchanger respectively.
When printing low-temperature biological material, adopt low temperature shower nozzle, in the coaming plate of low temperature shower nozzle and print platform, pass to the cooling fluid of uniform temperature, thus ensure print temperature; When printing high-temperature biological material, adopt high temp. jetting nozzle, high temp. jetting nozzle heats separately, passes to the hot fluid of uniform temperature in the coaming plate of print platform, thus ensures print temperature.
The biomaterial kind that the present invention can print is many, as: hydroxyapatite, titanium , tricalcium phosphate carbon etc. are for the material of bore regenerating, polycaprolactone, PLA, poly lactic coglycolic acid etc. are for the material of medicine controlled releasing, agar, poly glucosamine, alginate, gelatin, ossein, cellulose etc. are for the material of soft tissue biological structure and Organ printing, and polyurethane, silicone etc. are for the material of conceptual model.The present invention has fast, accurately, personalized and be good at the characteristic manufacturing complicated shape, can for the specific anatomic construction of patient, physiological function and Treatment need, based on electronic 3-D model, the method discrete by software hierarchy and numerical control is shaping, at shower nozzle inner position assembling biomaterial or living cells, the biomedical products such as Artificial Intervention support, histoorgan and medical auxiliary tool are produced by printing, thus for developing the technology possibility that breakthrough medical treatments provides new.The present invention is easy to operate, and use flexibly, the scope of application is wide, and low to cellular damage rate, printing precision is high.
Claims (6)
1. a biological 3D printing equipment, it is characterized in that comprising print platform (1), three-axis moving mechanism, wire squeeze mechanism (2), shower nozzle (3) and heat preservation mechanism, three-axis moving mechanism and print platform (1) are arranged on the chassis (13) of printing equipment respectively, wire squeeze mechanism (2) is connected with three-axis moving mechanism, described shower nozzle (3) is arranged in described wire squeeze mechanism (2), and shower nozzle (3) points to described print platform (1) down, heat preservation mechanism is located on described print platform (1).
2. the biological 3D printing equipment of one according to claim 1, it is characterized in that described wire squeeze mechanism (2) is comprised installing rack (4), is located at the pushing block (6) controlled by motor (5) on installing rack (4) and the piston be connected by connecting rod (7) with pushing block (6), described shower nozzle (3) is arranged on the bottom of installing rack (4), and described piston is located in described shower nozzle (3).
3. the biological 3D printing equipment of one according to claim 1, is characterized in that described shower nozzle (3) is for high temp. jetting nozzle or low temperature shower nozzle.
4. the biological 3D printing equipment of the one according to claim 1 or 2 or 3, it is characterized in that described heat preservation mechanism comprises heat exchange coil (8), the surrounding of described print platform (1) is provided with coaming plate (16), left side, right side and the coaming plate of rear side and the back side of print platform are equipped with described heat exchange coil (8), heat exchange coil has hot fluid or cooling fluid in (8), and heat exchange coil (8) is connected with heat exchanger.
5. the biological 3D printing equipment of one according to claim 4, is characterized in that the coaming plate of described print platform (1) front side is block transparent panel (9).
6. the biological 3D printing equipment of the one according to claim 1 or 2 or 3, it is characterized in that described three-axis moving mechanism comprises Y-direction motion (10), X is to motion (11) and Z-direction motion (12), Y-direction motion (10) is located at left side and the right side on the chassis (13) of printing equipment, Y-direction motion (10) is provided with a vertically disposed platform (14), X is located at platform (14) top to motion (11), X is provided with a back-up block (15) on motion (11), described Z-direction motion (12) is located on described back-up block (15), described wire squeeze mechanism (2) is arranged on Z-direction motion (12).
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| CN201310658657.2A CN104690961A (en) | 2013-12-06 | 2013-12-06 | Biological 3D printing apparatus |
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| CN201310658657.2A CN104690961A (en) | 2013-12-06 | 2013-12-06 | Biological 3D printing apparatus |
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| CN105751500A (en) * | 2016-02-24 | 2016-07-13 | 浙江大学 | Porous bone scaffold manufacturing device and method |
| CN105750545A (en) * | 2016-03-29 | 2016-07-13 | 上海卫星工程研究所 | Method using 3D printing to manufacture heat exchanger |
| TWI577448B (en) * | 2016-01-04 | 2017-04-11 | 國立中央大學 | Manufacturing method of low-temperature rapid manufacturing support structure and manufacturing method of low-temperature rapid manufacturing support structure |
| TWI593547B (en) * | 2015-11-13 | 2017-08-01 | 財團法人工業技術研究院 | Three dimensional tissue printing device, three dimensional tissue printing method and artifical skin |
| TWI597184B (en) * | 2016-09-26 | 2017-09-01 | 東台精機股份有限公司 | Heating and refrigerating device |
| CN107696478A (en) * | 2017-11-18 | 2018-02-16 | 北京工业大学 | A kind of high speed 3D printer comprising cooling system |
| CN109843554A (en) * | 2016-08-12 | 2019-06-04 | Elc 管理有限责任公司 | For the device by the building file printing three-dimensional cosmetic preparation comprising cosmetic formulations |
| CN110549618A (en) * | 2019-08-22 | 2019-12-10 | 浙江大学 | Biological 3D printing system |
| CN110742294A (en) * | 2019-10-22 | 2020-02-04 | 江南大学 | Microwave-assisted three-dimensional printing device and accurate and efficient printing method for plant gel system |
| CN111543665A (en) * | 2020-05-09 | 2020-08-18 | 江南大学 | Microwave-induced 4D printer and application thereof |
| CN111685365A (en) * | 2019-03-13 | 2020-09-22 | 秦皇岛烟草机械有限责任公司 | Cigarette 3d printer |
| CN112297176A (en) * | 2020-10-21 | 2021-02-02 | 康硕电气集团有限公司 | Ceramic 3D printer and control method thereof |
| CN112891016A (en) * | 2021-01-18 | 2021-06-04 | 华中科技大学鄂州工业技术研究院 | Biological 3D of controllable temperature low temperature prints shower nozzle device |
| CN114261089A (en) * | 2021-12-24 | 2022-04-01 | 浙江大学滨海产业技术研究院 | Desktop-level biological 3D printer device and method |
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| TWI593547B (en) * | 2015-11-13 | 2017-08-01 | 財團法人工業技術研究院 | Three dimensional tissue printing device, three dimensional tissue printing method and artifical skin |
| TWI577448B (en) * | 2016-01-04 | 2017-04-11 | 國立中央大學 | Manufacturing method of low-temperature rapid manufacturing support structure and manufacturing method of low-temperature rapid manufacturing support structure |
| CN105666868A (en) * | 2016-01-22 | 2016-06-15 | 深圳市创必得科技有限公司 | Automatic removing method for 3D printing model |
| CN105666868B (en) * | 2016-01-22 | 2017-11-03 | 深圳市创必得科技有限公司 | A kind of automatic removing method of 3D printing model |
| CN105751500B (en) * | 2016-02-24 | 2018-12-11 | 浙江大学 | A kind of porous bone scaffold manufacturing device and manufacturing method |
| CN105751500A (en) * | 2016-02-24 | 2016-07-13 | 浙江大学 | Porous bone scaffold manufacturing device and method |
| CN105750545A (en) * | 2016-03-29 | 2016-07-13 | 上海卫星工程研究所 | Method using 3D printing to manufacture heat exchanger |
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| CN109843554B (en) * | 2016-08-12 | 2022-03-01 | Elc 管理有限责任公司 | Apparatus for printing three-dimensional cosmetic product from build material containing cosmetic formulation |
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| CN107696478A (en) * | 2017-11-18 | 2018-02-16 | 北京工业大学 | A kind of high speed 3D printer comprising cooling system |
| CN107696478B (en) * | 2017-11-18 | 2019-11-29 | 北京工业大学 | A kind of high speed 3D printer comprising cooling system |
| CN111685365A (en) * | 2019-03-13 | 2020-09-22 | 秦皇岛烟草机械有限责任公司 | Cigarette 3d printer |
| CN110549618A (en) * | 2019-08-22 | 2019-12-10 | 浙江大学 | Biological 3D printing system |
| CN114274508A (en) * | 2019-08-22 | 2022-04-05 | 浙江大学 | Biological 3D printing system |
| CN110742294A (en) * | 2019-10-22 | 2020-02-04 | 江南大学 | Microwave-assisted three-dimensional printing device and accurate and efficient printing method for plant gel system |
| WO2021077561A1 (en) * | 2019-10-22 | 2021-04-29 | 江南大学 | Microwave-coordinated three-dimensional printing apparatus, and accurate and efficient printing method for plant gel system |
| CN110742294B (en) * | 2019-10-22 | 2021-07-23 | 江南大学 | Microwave-assisted three-dimensional printing device and accurate and efficient printing method for plant gel system |
| AU2019471247B2 (en) * | 2019-10-22 | 2023-02-02 | Jiangnan University | Microwave-coordinated three-dimensional printing apparatus, and accurate and efficient printing method for plant gel system |
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| CN112297176A (en) * | 2020-10-21 | 2021-02-02 | 康硕电气集团有限公司 | Ceramic 3D printer and control method thereof |
| CN112891016A (en) * | 2021-01-18 | 2021-06-04 | 华中科技大学鄂州工业技术研究院 | Biological 3D of controllable temperature low temperature prints shower nozzle device |
| CN114290476A (en) * | 2021-12-23 | 2022-04-08 | 集美大学 | Paste ceramic 3D printing method for curved-surface thin-wall part |
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