CN104623790A - Medical guide wire and conveying system - Google Patents
Medical guide wire and conveying system Download PDFInfo
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- CN104623790A CN104623790A CN201310557153.1A CN201310557153A CN104623790A CN 104623790 A CN104623790 A CN 104623790A CN 201310557153 A CN201310557153 A CN 201310557153A CN 104623790 A CN104623790 A CN 104623790A
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- seal wire
- guiding wire
- medical guiding
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Abstract
The invention provides a medical guide wire and a conveying system. The medical guide wire comprises a reducing central spindle and a protective jacket. The reducing central spindle comprises a linear equal-diameter section, a streamline reducing section and a linear reducing section from the near end to the far end, wherein the diameter of the linear equal-diameter section, the diameter of the streamline reducing section and the diameter of the linear reducing section decrease in sequence. The protective jacket is arranged at least around the streamline reducing section and the linear reducing section of the reducing central spindle. The protective jacket further comprises a developing spring ring and a metal tube of a hollowed-out structure, the metal tube and/or the spring ring are/is coated with a high-molecular polymer coating, and the high-molecular polymer coating is coated with a hydrophilic coating. Compared with existing medical guide wires, the medical guide wire has excellent comprehensive performance.
Description
Technical field
The present invention relates generally to medical apparatus and instruments, particularly for conveying and the conveyer device placing implant (as artificial valve, intravascular stent).Particularly, in first aspect, the present invention relates to the medical guiding wire for conveyer device.In second aspect, the present invention relates to the induction system comprising medical guiding wire.
Background technology
In intervene operation, utilize seal wire to be imported by the related equipment such as catheter in blood vessel and make it to arrive diseased region.
Medical guiding wire is generally divided into delivery guidewire and guiding wire, and this two classes seal wire is structurally similar.Medical guiding wire generally comprises three parts: the softness of far-end is most advanced and sophisticated, the push rod section of interlude and near-end, and softness tip and push rod section couple together by interlude.Medical guiding wire can be having structure: mandrel, turn or hypotube or two or more the combination in them.The material of medical guiding wire can be high molecular polymer or metal.In addition, medical guiding wire also should comprise hydrophilic coating and/or hydrophobic coating.
The structural design that medical guiding wire the is different and performance of medical guiding wire can be caused different to the selection of material, the performance of seal wire as propelling movement property, turn round control property, developability, pliability, penetrance and lubricity etc.And then according to different performances, medical guiding wire has different purposes.
Chinese patent application 200380105092.X discloses a kind of medical guiding wire, it easily imports from the blood vessel introducing port of huckle, upper arm or wrist etc., easily bend at Ink vessel transfusing and be difficult to enter in turnoff by mistake, it is made up of by the metal core wire that resin covers surface, have and bend to round and smooth curvilinear leading section, it is characterized in that, the diameter comprising the seal wire of resin bed is 0.46 ~ 1.02mm, and the direction extended line of this front end and seal wire baseline angulation are 40 ~ 70 degree, and the width dimensions of curve part is more than 2mm, less than 10mm.
International patent application WO2006/058234A2 discloses a kind of medical apparatus and instruments, it has the hypotube of the coating of highly flexible, it is layer that this hypotube is coated with one or more layers, is suitable for applying hydrophilic coating subsequently, makes the flexibility of medical apparatus and instruments equal with the flexibility of hypotube at least haply.
US Patent No. 6004279 discloses a kind of medical guiding wire, and it is in insertosome, to provide the passage entered in body.This medical guiding wire has main proximal part, and it is extension tubing form, extends most of length of medical guiding wire, and distal tubu lar portion, itself and main proximal part form one, and distal tubu lar portion comprises far-end head end and compliant section, and have otch on the tube wall of distal tubu lar portion.
US Patent No. 2011/0160703A1 also discloses a kind of medical guiding wire; it has the flexibility of high security and improvement and rotates followability; this seal wire has the inner ring of the distal side part around mandrel; with the outer ring of the distal side part around inner ring and mandrel; and the front end of the front end of outer ring and inner ring is linked to the tip of mandrel by most advanced and sophisticated plug, thus make the distal side part of seal wire by coiled coil structural defence.In addition, this seal wire has coil connectors, its only by outer ring and inner ring connected to each other.
The design of current medical guiding wire is only optimized for indivedual performance, and does not have or seldom consider the combination property of seal wire.Such as, what the design of hypotube in WO2006/058234A2 improve seal wire turns round control performance, but the coating in hypotube can reduce the pliability of seal wire.Although can improve the pliability of seal wire by improving coating, the pliability of seal wire also can be subject to the restriction of hypotube structure, and the space of raising is little.
The excision design of the far-end spring-like circle of the Nitinol metal tube in US6004279 improves the pliability of seal wire, but but reduces the developability of seal wire.And the near-end of metal tube, without any improvement design, makes the pliability of seal wire also be affected.
Summary of the invention
The object of the invention is the combination property improving medical guiding wire, make medical guiding wire have better pliability, turn round control property, tactile feedback, developability, " navigation " effect.
According to a first aspect of the invention, provide a kind of medical guiding wire, it comprises reducing mandrel and protective sleeve.Described reducing mandrel proximally arrives far-end and comprises isometrical section of linear type, streamlined reducer and the linear type reducer that diameter reduces successively.Described protective sleeve is at least arranged around the streamlined reducer of reducing mandrel and linear type reducer.
Preferably, described protective sleeve also comprises the metal tube of development turn and engraved structure.In addition, preferably, described metal tube and/or described development turn are coated with coating of high molecular polymer.
Streamlined reducer according to the present invention more effectively can improve handling and the tracking performance of seal wire compared with linear type reducer.And the metal tube of hollow out design has good super-elasticity, effectively can resist the kink that seal wire produces in twist operation process, and make seal wire in operation can 1:1 transmitting torque, reduce the loss of energy, improve the handling of seal wire.In addition, the existence containing the coating of high molecular polymer of radiopaque metal can improve the visual performance of seal wire, development turn arranges the visual performance that described coating is more the increase in development turn, seal wire is located in the blood vessel better.Although described coating makes the pliability of seal wire have certain loss, but the metal tube of hollow out design produces less metal coverage rate, effectively improve the pliability of seal wire, thus make seal wire more be adapted to tortuous, tiny blood vessel, improve the operability of seal wire.
According to the present invention, reducing mandrel can be formed by grinding by one or more in the materials such as rustless steel, NiTi class alloy, copper class alloy, aluminum class alloy, or is formed by bonding by the bi-material in above-mentioned material.The diameter of mandrel can regulate according to the tortuous degree of blood vessel, usually the distal diameter of about 0.010 ~ 0.002 inch is reduced to from the proximal diameter of 0.020 ~ 0.010 inch, preferably being reduced to the distal diameter of about 0.005 ~ 0.002 inch from the proximal diameter of 0.020 ~ 0.012 inch, is most preferably be reduced to the distal diameter of 0.002 inch from the proximal diameter of 0.014 inch.The length of isometrical section of the linear type of the near-end of mandrel can be 2200 ~ 2600mm, is preferably 2400 ~ 2550mm, most preferably is 2520mm.The length of the streamlined reducer of mandrel can be 380 ~ 780mm, is preferably 400 ~ 550mm, most preferably is 450mm.The length of the linear type reducer of the far-end of mandrel can be 20 ~ 50mm, is preferably 30mm.
According to the present invention, development turn can be made up of one or more materials radiopaque, as one or more in gold, iridium, tungsten, platinum, tantalum etc., is preferably platinum.
Preferably, described coating of high molecular polymer also applies hydrophilic coating.According to the present invention, described polymer coating is effective as " substrate " and provides " support " for hydrophilic coating, and hydrophilic coating is coated on metal tube and/or development turn fully effectively.Polymer coating applies smoothness and tracking performance that hydrophilic coating can improve seal wire, and the biocompatibility of metal tube and development turn can be improved.
Preferably, the wall thickness of the metal tube of hollow out design is 0.07 ~ 0.08mm, and external diameter is about 0.32mm.
Preferably, metal tube is by Nitinol(Nitinol) make.
Preferably, the engraved structure of metal tube is rhombus, and the short-axis direction of described rhombus is parallel with the axis of metal tube.The engraved structure of rhombus can improve the pliability of seal wire, makes seal wire effectively comply with tortuous blood vessel, avoids blood vessel to be straightened in the propelling movement process of seal wire.Certainly, other shape is also possible.
Preferably, the angle of the acute angle of rhombus is about 10 °.The pliability of seal wire at this moment and safety the best.
Preferably, turn is at least arranged on linear type reducer, and metal tube is then arranged on streamlined reducer, and turn and metal tube are connected with each other, such as, by welding.In this way, development turn is arranged on mandrel far-end, is convenient to locate the position arriving diseased region.Development turn can also be arranged on a part of streamlined reducer.
Preferably, the turn that develops has the design reduced gradually to distal outer diameter by near-end.This design improves the navigation performance of seal wire in endovascular propelling movement process, and this design improves the ability that seal wire passes through chronic disease position, stenotic lesion position simultaneously.
Preferably, in development turn is fixed on reducing mandrel distal tip by nut or be welded in the distal tip of reducing mandrel by turn far-end, described reducing mandrel is then directly connected with nut or solder joint.The sense of touch that nut or solder joint transmit can be fed back to operator by preferably, and preferably the propelling movement power that operator applies effectively can also be delivered to the far-end of seal wire.In addition, preferably, uncoated any coating on the solder joint on described nut or between the distal tip of turn far-end and reducing mandrel, to make the distal tip of seal wire have good tactile feedback.Because tactile feedback performance impact the manipulation ability of operator to seal wire, so the distal tip of seal wire does not apply the tactile feedback performance that any coating can improve seal wire, and then improve the handling of seal wire.
Preferably, the spiral winding length of development turn is 10 ~ 40mm, is preferably 40mm.
Preferably, isometrical section of the linear type of reducing mandrel can be coated with hydrophobic coating.
The present invention improves the pliability of seal wire and turns round control from structural design aspect; Improve the visuality (developability) of seal wire.In addition, the design that the external diameter of the distal tip of seal wire diminishes gradually can reduce the resistance of seal wire in blood vessel or diseased region, improves the navigation function of seal wire; The nut of distal tip or solder joint do not have coating, tactile feedback capability and the handling of seal wire can be strengthened.
According to a second aspect of the invention, a kind of induction system comprising above-mentioned medical guiding wire is provided.
Accompanying drawing explanation
By with reference to the accompanying drawings to the detailed description that the embodiment of the present invention is carried out, feature of the present invention and advantage thereof will be apparent.Obviously, described embodiment is only a part of embodiment of the present invention, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art can obtain other embodiments all not making under creative work prerequisite, and these embodiments all belong to the scope of protection of the invention.In the drawings:
Fig. 1 shows the population structure schematic diagram of the seal wire according to the embodiment of the present invention;
Fig. 2 shows the structural representation of the reducing mandrel of the seal wire of the embodiment of the present invention;
Fig. 3 shows the perspective view of the Nitinol pipe of the rhombus engraved structure of the seal wire of the embodiment of the present invention;
Fig. 4 shows the expansion schematic diagram of the Nitinol pipe of this rhombus engraved structure;
The distal tip that Fig. 5 shows the seal wire of the embodiment of the present invention passes through the situation of diseased region;
Fig. 6 shows the situation of distal tip at vascular bifurcation place of the seal wire of the embodiment of the present invention;
Fig. 7 shows nut or the solder joint of the distal tip of the seal wire of the embodiment of the present invention.
Reference numerals list
1 nut or solder joint; 2 development turns; 3 solders; 4 reducing mandrels; The Nitinol pipe of 5 rhombus engraved structures; 6 coating of high molecular polymer; 7 hydrophilic coatings; 8 hydrophobic coatings; 10 linear type reducers; 20 streamlined reducers; Isometrical section of 30 linear types; The rib of 40 metal tubes; 50 openwork parts; A angle; W width; L length; 100 stenotic lesion positions; 200 blood vessels
Detailed description of the invention
The embodiment of medical guiding wire of the present invention is described with reference to the accompanying drawings.In the following description, for convenience of description, employ " far-end " and " near-end ", its reference be the side of side away from seal wire operating side and Proximity operation end respectively.
Fig. 1 shows the population structure schematic diagram of the seal wire of the embodiment of the present invention.Seal wire comprises reducing mandrel 4 and protective sleeve.Described protective sleeve is arranged around the streamlined reducer 20 of reducing mandrel and linear type reducer 10, and it comprises the Nitinol pipe metal tube 5 of development turn 2 and engraved structure, development turn 2 is arranged on linear type reducer 10 and the streamlined reducer 20 of a part and its far-end is fixed on the end (i.e. the distal tip of reducing mandrel 4) of linear type reducer 10 by nut or solder joint 1, metal tube 5 is arranged on streamlined reducer 20 and one end and is fixed on streamlined reducer 20 by solder 3, and the other end of metal tube 5 is together with development being welded to one another proximally by solder 3 of turn, metal tube 5 and development turn 2 are also coated with coating of high molecular polymer 6.In addition, polymer coating 6 is also coated with outer field hydrophilic coating 7, the linear type of reducing mandrel 4 isometrical section 30 is then coated with hydrophobic coating 8.Fig. 1 also demonstrates development turn and is reduced gradually to distal outer diameter by near-end, and the distal outer diameter of seal wire is reduced gradually.
Fig. 2 shows the detailed construction schematic diagram of the reducing mandrel of the seal wire of the embodiment of the present invention.Reducing mandrel 4 proximally arrives far-end and comprises linear type isometrical section 30, streamlined reducer 20 and linear type reducer 10, and its diameter reduces successively.
Fig. 3-4 shows the detailed construction schematic diagram of the Nitinol metal tube of the seal wire of the embodiment of the present invention, and Fig. 3 shows perspective view, and Fig. 4 shows expanded view.Can see the engraved structure of Nitinol metal tube from the expanded view shown in Fig. 4, the similar rhombus of its openwork part 50, the short-axis direction of rhombus is parallel with the axis of metal tube.This openwork part 50 has angle A and length L and width W.The length of openwork part, width and angle can change, and this affects the surface metal coverage rate of Nitinol metal tube, then has an impact to the pliability of seal wire.In this example, being respectively of a size of under non-deformation: length L is about 23mm, and width W is about 2.3mm, and angle A is about 10 °.When angle A is less than 10 °, the flexility of seal wire reduces; When angle A is greater than 10 °, the security performance of seal wire can be affected.
The engraved structure of Nitinol metal tube of the present invention makes seal wire turn round in control process, and torsion can transmit along the rib 40 of Nitinol metal tube, effectively reduces the loss of energy, moment of torsion 1:1 is effectively delivered to the far-end of seal wire.In addition, at seal wire in endovascular propelling movement process, seal wire can bend with tortuous blood vessel, and now the length L of openwork part 50 and width W can change according to the bending direction of seal wire and amount of curvature, then change the pliability of seal wire.
The distal tip of the seal wire that Fig. 1 demonstrates is designed to the structure that external diameter reduces gradually, and this effectively can improve the navigation function of seal wire at Ink vessel transfusing and diseased region.As shown in Figure 5, the distal tip of seal wire effectively can enter the slype of thrombosis, provides " navigation " to act on for seal wire passes through diseased region 100.If the diameter of the distal tip of seal wire is constant and when being greater than the bore of one end of slype, the distal tip of seal wire is then difficult to the passage entering thrombosis.Like this, propelling movement power can cause the distal tip of seal wire to bend, and seal wire can be caused damaged, thus produce destruction to blood vessel time serious.Difficulty and the risk of operation seal wire is greatly reduced according to the variable diameter design of the distal tip of seal wire of the present invention.In addition, as shown in Figure 6, the distal tip of seal wire is designed to the structure that external diameter reduces gradually, and because having good development effect, so easily and effectively can select at the crotch of blood vessel 200 and enter the blood vessel at diseased region 100 place.
Fig. 7 shows the nut of the distal tip of seal wire or the structural design of solder joint 1.The uncoated any coating in surface of nut or solder joint 1, makes nut or solder joint directly will contact with blood vessel or diseased region, which reduces the impact that the tactile feedback caused because of the existence of coating is little or postpone, improves the safety of operation.In addition, in this example, the distal tip that have employed mandrel is directly connected (Core-to-Tip) and designs with nut or solder joint, the sense of touch that nut or solder joint transmit can be fed back to operator by preferably, and preferably the propelling movement power that operator applies effectively can also be delivered to the far-end of seal wire.
The hollow out design of the rhombus of Nitinol metal tube of the present invention substantially reduces the flexible impact reducing seal wire because of the existence of coating; Development turn containing noble metal and the use of roentgenopaque coating improve the visuality of seal wire; The design that the external diameter of the distal tip of seal wire diminishes gradually improves the navigation function of seal wire; The do not have nut of applying coating or the solder joint of distal tip enhance tactile feedback capability and the handling of seal wire.Therefore, seal wire of the present invention effectively optimizes the combination property of seal wire structural design: flexility, handling, propelling movement performance, navigation performance and tactile feedback performance, visual performance etc.
Induction system of the present invention comprises above-mentioned medical guiding wire.Other parts and the use of induction system are all well known to those skilled in the art, do not describe in detail at this.
By the above-mentioned explanation of the disclosed embodiments, professional and technical personnel in the field can realize or use the present invention.The multiple amendment of these embodiments will be apparent to those skilled in the art.General Principle as defined herein can without departing from the spirit or scope of the present invention, realize in other embodiments.Therefore, the invention is not restricted to these embodiments shown in this article, but contain and meet the widest scope consistent with principle disclosed herein.
Claims (11)
1. a medical guiding wire; it comprises reducing mandrel and protective sleeve; it is characterized in that; described reducing mandrel proximally arrives far-end and comprises isometrical section of linear type, streamlined reducer and the linear type reducer that diameter reduces successively, and described protective sleeve is at least arranged around the streamlined reducer of reducing mandrel and linear type reducer.
2. medical guiding wire according to claim 1, is characterized in that, described protective sleeve also comprises the metal tube of development turn and engraved structure.
3. medical guiding wire according to claim 2, is characterized in that, described metal tube and/or described development turn are coated with coating of high molecular polymer.
4. medical guiding wire according to claim 3, is characterized in that, described coating of high molecular polymer is also coated with hydrophilic coating.
5. medical guiding wire according to claim 2, is characterized in that, the openwork part of metal tube is rhombus, and the short-axis direction of described rhombus is parallel with the axis of metal tube.
6. medical guiding wire according to claim 5, is characterized in that, the angle of the acute angle of described rhombus is 10 °.
7. medical guiding wire according to claim 2, is characterized in that, development turn is at least arranged on linear type reducer, and metal tube is arranged on streamlined reducer, and development turn and metal tube are connected with each other.
8. medical guiding wire according to claim 7, it is characterized in that, in development turn is fixed on reducing mandrel distal tip by nut or be welded in the distal tip of reducing mandrel by the far-end of development turn, described reducing mandrel is then directly connected with nut or solder joint.
9. medical guiding wire according to claim 2, is characterized in that, the external diameter of development turn is reduced to far-end gradually by near-end.
10. medical guiding wire according to claim 1, is characterized in that, isometrical section of the linear type of reducing mandrel is coated with hydrophobic coating.
11. 1 kinds of induction systems, is characterized in that, described induction system comprises the medical guiding wire according to any one of claim 1-10.
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| CN201310557153.1A CN104623790A (en) | 2013-11-11 | 2013-11-11 | Medical guide wire and conveying system |
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| CN201310557153.1A CN104623790A (en) | 2013-11-11 | 2013-11-11 | Medical guide wire and conveying system |
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| CN104623790A true CN104623790A (en) | 2015-05-20 |
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| CN201310557153.1A Pending CN104623790A (en) | 2013-11-11 | 2013-11-11 | Medical guide wire and conveying system |
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Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107041993A (en) * | 2017-05-03 | 2017-08-15 | 北京灵泽医药技术开发有限公司 | A kind of medical guiding wire and medical tubing |
| CN107362437A (en) * | 2017-08-03 | 2017-11-21 | 湖南埃普特医疗器械有限公司 | A kind of predilation seal wire and preparation method thereof |
| CN107456647A (en) * | 2017-08-03 | 2017-12-12 | 湖南埃普特医疗器械有限公司 | A kind of seal wire and preparation method thereof |
| CN108024785A (en) * | 2015-06-15 | 2018-05-11 | 新宁研究院 | Intravascular imaging catheter and its application method |
| CN108926763A (en) * | 2018-07-28 | 2018-12-04 | 上海上医康鸽医用器材有限责任公司 | Microtubular, push component, Embolism for fallopian tube, dredging, contrast apparatus and application method |
| CN109045442A (en) * | 2018-09-06 | 2018-12-21 | 徐隋意 | Preforming seal wire in a kind of cerebral angiography |
| CN109173003A (en) * | 2018-10-10 | 2019-01-11 | 江苏尼科医疗器械有限公司 | Intermediate conductor |
| CN109481005A (en) * | 2018-09-25 | 2019-03-19 | 上海长海医院 | A kind of ganglioside GM_3 micro-wire monopolar coagulation |
| CN109938801A (en) * | 2017-12-21 | 2019-06-28 | 新昕医药科技（上海）有限公司 | A kind of thrombus takes bolt device |
| CN110075412A (en) * | 2019-04-25 | 2019-08-02 | 深圳泓一生物医疗科技有限公司 | A kind of seal wire |
| CN111405923A (en) * | 2018-02-01 | 2020-07-10 | 朝日英达科株式会社 | Guide wire |
| CN111956934A (en) * | 2020-08-31 | 2020-11-20 | 尚华 | Medical guide wire |
| CN112587782A (en) * | 2020-12-07 | 2021-04-02 | 上海璞慧医疗器械有限公司 | Medical guide wire |
| CN113082466A (en) * | 2021-04-08 | 2021-07-09 | 哈尔滨医科大学 | Guide wire |
| US11364363B2 (en) | 2016-12-08 | 2022-06-21 | Abiomed, Inc. | Overmold technique for peel-away introducer design |
| WO2022151971A1 (en) * | 2021-01-13 | 2022-07-21 | 微创神通医疗科技（上海）有限公司 | Conveying guide wire and manufacturing method therefor |
| CN114887199A (en) * | 2017-05-25 | 2022-08-12 | C.R.巴德有限公司 | Guide wire |
| US11793977B2 (en) | 2018-05-16 | 2023-10-24 | Abiomed, Inc. | Peel-away sheath assembly |
| CN117752919A (en) * | 2024-02-20 | 2024-03-26 | 北京深瑞达医疗科技有限公司 | Guide wire |
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| CN108024785B (en) * | 2015-06-15 | 2021-03-09 | 新宁研究院 | Intravascular imaging catheter and method of use |
| CN108024785A (en) * | 2015-06-15 | 2018-05-11 | 新宁研究院 | Intravascular imaging catheter and its application method |
| US11717640B2 (en) | 2016-12-08 | 2023-08-08 | Abiomed, Inc. | Overmold technique for peel-away introducer design |
| US11364363B2 (en) | 2016-12-08 | 2022-06-21 | Abiomed, Inc. | Overmold technique for peel-away introducer design |
| CN107041993A (en) * | 2017-05-03 | 2017-08-15 | 北京灵泽医药技术开发有限公司 | A kind of medical guiding wire and medical tubing |
| CN114887199A (en) * | 2017-05-25 | 2022-08-12 | C.R.巴德有限公司 | Guide wire |
| CN107362437A (en) * | 2017-08-03 | 2017-11-21 | 湖南埃普特医疗器械有限公司 | A kind of predilation seal wire and preparation method thereof |
| CN107456647A (en) * | 2017-08-03 | 2017-12-12 | 湖南埃普特医疗器械有限公司 | A kind of seal wire and preparation method thereof |
| CN109938801A (en) * | 2017-12-21 | 2019-06-28 | 新昕医药科技（上海）有限公司 | A kind of thrombus takes bolt device |
| CN111405923A (en) * | 2018-02-01 | 2020-07-10 | 朝日英达科株式会社 | Guide wire |
| US11793977B2 (en) | 2018-05-16 | 2023-10-24 | Abiomed, Inc. | Peel-away sheath assembly |
| CN108926763A (en) * | 2018-07-28 | 2018-12-04 | 上海上医康鸽医用器材有限责任公司 | Microtubular, push component, Embolism for fallopian tube, dredging, contrast apparatus and application method |
| CN109045442A (en) * | 2018-09-06 | 2018-12-21 | 徐隋意 | Preforming seal wire in a kind of cerebral angiography |
| CN109481005A (en) * | 2018-09-25 | 2019-03-19 | 上海长海医院 | A kind of ganglioside GM_3 micro-wire monopolar coagulation |
| CN109173003A (en) * | 2018-10-10 | 2019-01-11 | 江苏尼科医疗器械有限公司 | Intermediate conductor |
| CN109173003B (en) * | 2018-10-10 | 2024-04-09 | 江苏尼科医疗器械有限公司 | Intermediate catheter |
| CN110075412A (en) * | 2019-04-25 | 2019-08-02 | 深圳泓一生物医疗科技有限公司 | A kind of seal wire |
| WO2022041559A1 (en) * | 2020-08-31 | 2022-03-03 | 尚华 | Medical guidewire |
| CN111956934A (en) * | 2020-08-31 | 2020-11-20 | 尚华 | Medical guide wire |
| CN112587782A (en) * | 2020-12-07 | 2021-04-02 | 上海璞慧医疗器械有限公司 | Medical guide wire |
| WO2022151971A1 (en) * | 2021-01-13 | 2022-07-21 | 微创神通医疗科技（上海）有限公司 | Conveying guide wire and manufacturing method therefor |
| CN113082466A (en) * | 2021-04-08 | 2021-07-09 | 哈尔滨医科大学 | Guide wire |
| CN117752919A (en) * | 2024-02-20 | 2024-03-26 | 北京深瑞达医疗科技有限公司 | Guide wire |
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