CN104548344B - Injection type nerve stimulator with power supplied by radio frequency energy - Google Patents
Injection type nerve stimulator with power supplied by radio frequency energy Download PDFInfo
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- CN104548344B CN104548344B CN201510020720.9A CN201510020720A CN104548344B CN 104548344 B CN104548344 B CN 104548344B CN 201510020720 A CN201510020720 A CN 201510020720A CN 104548344 B CN104548344 B CN 104548344B
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Abstract
The invention discloses an injection type nerve stimulator with power supplied by radio frequency energy. The nerve stimulator is composed of a cylindrical shell provided with a cavity, electrodes connected to through holes in the two ends of the shell in a penetrating mode, a hole formed in a ball head of one electrode, antennae arranged on the inner wall of the shell in a coating mode, a rechargeable battery, a microcontroller, a micro never stimulator module, a data receiving module, a radio frequency energy collection module, a biological and temperature sensor, a pressure sensor and filling, wherein the rechargeable battery, the microcontroller, the micro never stimulator module, the data receiving module, the radio frequency energy collection module, the biological and temperature sensor and the pressure sensor are sequentially arranged in the shell in a spaced mode, sealing is achieved between the electrode and the shell, power is supplied to the functional modules by the radio frequency energy collecting module, the sensors are used for monitoring environment variables and nerve stimulation processes, and the filling is used for space filling and part fixation. The nerve stimulator can be directly injected into target spot nerves or muscular tissue an implanted nerve stimulator can not reach through an injector, and is suitable for low-impulse amplitude stimulation.
Description
Technical field
The invention belongs to biomedical electronics Medical Instruments technical field.It is related to a kind of injection nerve stimulator, more
It is specifically related to the injection nerve stimulator that a kind of radio-frequency (RF) energy is powered.Present invention is mainly applied in biologic medical, to god
Warp or muscle are stimulated.
Background technology
Nerve stimulator is a kind of biologic medical electronic installation.It is used for producing low-frequency electric pulse and carries out function to organism
Property nerve electric stimulation, to reach relieving the pain caused by diseases symptom, recover or adjustment nerve or muscle the effect such as function.Nerve stimulator can
So that by neurologist, nurse or the technical staff through training are calibrated, to meet the concrete needs of individuals patients.Mesh
On front market comparative maturity and most widely used be embedded nerve stimulator.This nerve stimulator must pass through surgical operation
It is implanted in people or the body of other animals, there is following limitation：1) embedded nerve stimulator is implanted to body
Inside need the operation by the long period (as implantation brain depth stimulator needs about 12 hours), patient must stand necessarily
Misery；2) with respect to the specific target nerve needing and stimulating, embedded nerve stimulator relatively large sized is it is impossible to quilt
It is implanted to (as brain) in target nerve or the muscular tissue limited by shape or volume；In order to stimulus signal is conducted to brain portion
Position, needs to introduce longer electrode extension lead on electrode；But electrode extension lead be easy to be moved it is possible to
An electricity irritation is caused in the position of mistake, and this can greatly increase the risk of infection.And appointing in embedded nerve stimulator
The infection what part is induced often is diffused in whole system, in such a case it is necessary to again by surgical operation pair
Battery or whole implantable neural stimulator are changed；3) general embedded nerve stimulator on Vehicles Collected from Market is mainly using non-
Rechargeable battery powered, electric energy can be depleted in 4 to 10 years, now needs replacing battery of performing the operation again, therefore its week life-cycle
Phase is shorter；4) implantation embedded nerve stimulator, after implanting, in the event of uncomfortable, when needing to remove or change, needs
To be performed the operation again, the secondary injury therefore when injected organism tissue being caused is larger.
Content of the invention
The invention aims to solving and overcoming above-mentioned prior art, especially existing for embedded nerve stimulator
Technical problem and defect, provide the injection nerve stimulator that a kind of radio-frequency (RF) energy is powered.The radio-frequency (RF) energy of the present invention is powered
Injection nerve stimulator, there is no the document introduction of correlation at present, does not also search the patent document of correlation.
For achieving the above object, the technical solution used in the present invention is：
The injection nerve stimulator that a kind of radio-frequency (RF) energy is powered, by shell 1, electrode 2, antenna 3, rechargeable battery 4, micro-
Controller and micro- nerve stimulator module 5, data reception module 6, radio-frequency (RF) energy collection module 7, biological and temperature sensor 8,
Pressure transducer 9, eyelet 10 and implant 11 etc. are constituted.
Described shell 1 is in order to protect injection nerve stimulator and the tissue erosion from other side mutually.Described electricity
Pole 2 is the interface between injection nerve stimulator and bio-tissue.Described antenna 3 is used for data transfer.Described chargeable
Battery 4 stores the electric energy collected by described radio-frequency (RF) energy collection module 7.Described microcontroller and micro- nerve stimulator module 5 are used
In the operation producing, manage and control injection nerve stimulator；Wherein micro- nerve stimulator produces polarity, an amplitude, accounts for
The pulse with frequency-adjustable for the empty ratio, provides suitable electricity irritation by described electrode 2 to nerve or muscular tissue；Microcontroller is used
In the operation managing and controlling injection nerve stimulator, for example, start or stop stimulation, monitor neurobehavioral, receive data it is believed that
Breath etc..Described data reception module 6 is used for decoding the stimulus signal information that external signal transmitter is sent, such as polarity, amplitude,
Dutycycle and frequency etc..The electromagnetic energy capturing is converted into electric energy by described radio-frequency (RF) energy module 7.Described biology and temperature sensing
Biosensor and temperature sensor are integrated on one module by device 8；Wherein the former is used for detecting nerve or muscular tissue
Behavior, extracts the signal of telecommunication and biological internal physiology or biochemical parameter etc.；The latter is used for perceiving the temperature of injection nerve stimulator
Degree and the temperature of itself interface and residing tissue between.Described pressure transducer 9 is used for injection nerve thorn after measurement injection
Sharp device pressure change in vivo, early warning risk.Described eyelet 10 is in order to remove injection nerve stimulator in a short time.Described
Implant 11 is used for space filling and part is fixed.
Described shell 1 is the cylinder with cavity, and the cylindrical two ends of shell 1 offer a through hole of coaxial line；Institute
Stating electrode 2 is 2 cylinders, and the cylindrical one end of described electrode 2 wears in the through hole being connected to shell 1, another elongated end end
Head is bulb；Described antenna 3 is 2, is coated in respectively and symmetrically on the inwall of described shell 1, one end of antenna 3 respectively with its
In described electrode 2 be connected, the other end and described microcontroller and micro- nerve stimulator module 5 and radio-frequency (RF) energy collection module
7 are connected, and connect after Capacitance Coupled to data reception module 6；Described rechargeable battery 4, radio-frequency (RF) energy collection module 7,
Microcontroller and micro- nerve stimulator module 5, data reception module 6, biological and temperature sensor 8 and pressure transducer 9 are from a left side
To right successively and in the mutually isolated cavity being placed in described shell 1；Two power connections of described rechargeable battery 4 successively with
The mode of series connection connects to described radio-frequency (RF) energy collection module 7, microcontroller and micro- nerve stimulator module 5, data reception
Block 6, biological and temperature sensor 8 and pressure transducer 9；Described biology and the two paths of signals of temperature sensor 8, and described pressure
One road signal of force transducer 9 is connected to described data reception module 6；Described microcontroller and micro- nerve stimulator module 5
Two paths of signals is also had to connect to described data reception module 6；Described eyelet 10 is in one of described electrode 2 end entity
The through hole of ball center；Described eyelet 10 is the centerline hole and electricity being opened up on the bulb of arbitrary in described 2 electrodes 2
One through hole of pole 2 axis perpendicular.Described implant 11 fills the internal remaining space of described shell 1, and fixes its internal institute
There is part.
Above-mentioned shell 1 is with having any one in the material manufacture of bio-compatibility, such as pottery or glass, preferably ceramic；Its
External diameter is less than the internal diameter of corresponding injection needle.
Above-mentioned electrode 2 is with having the conductor manufacture of bio-compatibility, such as platinum, platinum-iridium alloy, yttrium oxide, titanium nitride, silkworm silk
In any one, preferably platinum；The diameter of above-mentioned electrode 2 is less than the internal diameter of above-mentioned shell 1；Its end bulb with diameter greater than its cylinder
The diameter of body.
Above-mentioned antenna 3 is manufactured by metal micro-strip line.
Above-mentioned rechargeable battery 4 should be using the rechargeable battery with high-energy, such as lithium ion battery etc..
Above-mentioned rechargeable battery 4, microcontroller and micro- nerve stimulator module 5, data reception module 6, radio-frequency (RF) energy
Signal between collection module 7, biology and temperature sensor 8, pressure transducer 9 is connected by metallic bond zygonema.
The diameter of above-mentioned eyelet 9 is less than the diameter of the bulb of described electrode 2.
Above-mentioned implant 11 is any one in epoxy resin or gel, preferred epoxy.
The injection nerve stimulator that a kind of radio-frequency (RF) energy of the present invention is powered compared with prior art has the advantage that
And beneficial effect：
1st, the injection nerve stimulator powered due to a kind of radio-frequency (RF) energy of the present invention small-sized it is possible to logical
Cross syringe to be injected in target nerve or muscular tissue, and small-bore injection needle in can selecting (as 16G and with
Under), to reduce the damage to live body muscle tissue or nerve in injection process；
2nd, because the injection nerve stimulator that a kind of radio-frequency (RF) energy of the present invention is powered can be injected to implantable nerve
In the inaccessiable target nerve of stimulator institute or muscular tissue, therefore do not need electrode extension lead, thus greatly reducing
The risk of infection；
3rd, because the injection nerve stimulator that a kind of radio-frequency (RF) energy of the present invention is powered is powered using radio-frequency (RF) energy, its energy
Amount is wirelessly transferred, and can be stored in rechargeable battery, does not therefore need to change battery, life cycle management is long.
4th, because the injection nerve stimulator that a kind of radio-frequency (RF) energy of the present invention is powered has eyelet, therefore in injection
Initial stage, in the event of uncomfortable, fast can be removed, the secondary injury that when injected organism tissue is caused is little at original mouth.
Brief description
Fig. 1 is the organigram of the present invention；
Fig. 2 is electrode 2, antenna 3 and microcontroller and micro- nerve stimulator module 5, data reception module 6 and radio-frequency (RF) energy
Interface signal connection diagram between collection module 7；
Fig. 3 is rechargeable battery 4 and microcontroller and micro- nerve stimulator module 5, data reception module 6, radio-frequency (RF) energy
Power supply signal connection diagram between collection module 7, biology and temperature sensor 8 and pressure transducer 9；
Fig. 4 is microcontroller and micro- nerve stimulator module 5, data reception module 6, biological and temperature sensor 8 and pressure
Data signal connection diagram between force transducer 9.
In figure：1. shell, 2. electrode, 3. antenna, 4. rechargeable battery, 5. microcontroller and micro- nerve stimulator module,
6. data reception module, 7. radio-frequency (RF) energy collection module, 8. biological and temperature sensor, 9. pressure transducer, 10. eyelet, 11.
Implant.
Specific embodiment
In order to deepen the understanding of the present invention, with reference to embodiment and accompanying drawing, the present invention is described in further detail, should
Embodiment is only used for explaining the present invention, does not constitute the regulation to the scope of the present invention.
The implication of heretofore described " inside and outside " refers to respect to nerve stimulator itself, point to nerve thorn
Direction within sharp device is interior, otherwise is outer, rather than the specific restriction of the nerve stimulator to the present invention.
When the implication of heretofore described " left and right " refers to reader just to accompanying drawing, the left side of reader is a left side,
The right of reader is the right side, rather than the specific restriction of the nerve stimulator to the present invention.
The implication of heretofore described " connection " can be being directly connected between part can also be to pass through between part
Being indirectly connected with of other parts.
As Fig. 1, shown in Fig. 2, Fig. 3 and Fig. 4, the injection nerve stimulator that a kind of radio-frequency (RF) energy is powered, by shell 1, electricity
Pole 2, antenna 3, rechargeable battery 4, microcontroller and micro- nerve stimulator module 5, data reception module 6, radio-frequency (RF) energy are collected
Module 7, the biological and composition such as temperature sensor 8, pressure transducer 9, eyelet 10 and implant 11.Described shell 1 is to have sky
The cylinder in chamber, its external diameter (Φ 1) is 1 millimeter, and internal diameter is 0.9 millimeter, and length (L1) is 4 millimeters, is manufactured by pottery；Described pottery
The cylindrical two ends of ceramic shell 1 offer a through hole of a diameter of 0.42 millimeter of coaxial line, and each one sealing of placement in through hole is used
Ceramic cap.Described electrode 2 is (Φ 22) by 0.4 millimeter of diameter (Φ 21), the cylinder of 0.4 millimeter of length and end diameter
0.6 millimeter of bulb is constituted, all using metal platinum manufacture；The cylindrical end of two described platinum electrodes 2 is respectively fitted over described outer
To constitute anelectrode and negative electrode in the circular hole of shell 1 ceramic cap, and the ceramic metal with aluminium oxide as primary raw material is adopted to seal
Ring seals.Described antenna 3 by two width be 200 microns, thickness be 50 microns of microstrip line manufacture, symmetrically sunk using argent
Amass on the inwall of shell 1, in serpentine；One weld of every described antenna 3 in the cylindrical end of described electrode 2,
The other end connected to described microcontroller and micro- nerve stimulator module 5 (NS_OUT+ and NS_OUT-) by metallic bond zygonema and
Radio-frequency (RF) energy collection module 7 (RF_RX+ and RF_RX-), and (DATA_RX+ and DATA_RX-) connects to number after Capacitance Coupled
According to receiver module 6, as shown in Figure 2.The injection lithium ion that described rechargeable battery 4 is manufactured using Qullion company of the U.S. can
Rechargeable battery, its a diameter of 0.8 millimeter, length is 3 millimeters；Described rechargeable battery 4 is placed in described shell 1 inner cylinder
Left one side of something.Described microcontroller and micro- nerve stimulator module 5, data reception module 6, radio-frequency (RF) energy collection module 7, biology
And the functional module such as temperature sensor 8, pressure transducer 9 is from left to right successively and isolate the right one side of something being placed in spheroid, and all
Using based on 90 nanometers of CMOS technology manufacture, its signal each other passes through metallic bond zygonema and is connected.Described chargeable electricity
Two power connections (BAT+ and BAT-) in pond 4 are connected in series to successively to described radio-frequency (RF) energy collection module 7, micro-control
Device processed and micro- nerve stimulator module 5, data reception module 6, biological and temperature sensor 8 and pressure transducer 9, as Fig. 3 institute
Show.Pass through I between described microcontroller and micro- nerve stimulator module 5 data receiver module 62C bus (SDA and SCL) is led to
Letter；Bio signal (BIO) and temperature signal (TEMP) that described biological and temperature sensor 8 is perceived, and described pressure biography
The pressure signal (PRESSURE) that sensor 9 is perceived all inputs described data reception module 6, as shown in Figure 4.Described eyelet 10 is
The centerline hole being opened up on the bulb of arbitrary in described 2 electrodes 2 and a through hole of electrode 2 axis perpendicular, its
Diameter (Φ 10) is 0.1 millimeter.Described implant 11 adopts epoxy resin, fills the internal remaining space of described shell 1, and solid
Its internal all other part fixed.After loading all parts in described shell 1, the ceramic cap of described shell 1 is enclosed within it
Seal on cylindrical end, and sealed with O shape ceramic seal circle and ceramic seal glue.
Above example, the only present invention preferably specific embodiment.Certainly, the present invention also can have other multiple enforcements
Example, without departing substantially from the present invention spirit and its essence in the case of, any those familiar with the art, when can according to this
Various corresponding equivalent arrangements are made in invention, all should belong to the protection domain of appended claims of the invention.
The diameter of injection nerve stimulator and length all very littles that a kind of radio-frequency (RF) energy of the present invention is powered, can pass through
Syringe and from small-bore injection needle (as 16G and following), by its direct injection to embedded nerve stimulator institute
It is possible to fast remove in inaccessiable target nerve or muscular tissue.The present invention is applicable to relatively low pulse amplitude thorn
Sharp occasion.
Claims (7)
1. the injection nerve stimulator that a kind of radio-frequency (RF) energy is powered, including shell (1), electrode (2), antenna (3), chargeable electricity
Pond (4), microcontroller and micro- nerve stimulator module (5), data reception module (6), radio-frequency (RF) energy collection module (7), biology
And temperature sensor (8) and pressure transducer (9), it is characterized in that:Described shell (1) is the cylinder with cavity, described outer
The cylindrical two ends of shell (1) offer a through hole of coaxial line；Described electrode (2) is 2 cylinders being respectively mounted in through-holes
Body, the cylindrical one end of described electrode (2) wears in the through hole being connected to shell (1), and another elongated end termination is bulb；Described
Antenna (3) is 2, is coated in respectively and symmetrically on the inwall of described shell (1), one end of antenna (3) respectively with one of
Described electrode (2) is connected, the other end and described microcontroller and micro- nerve stimulator module (5) and radio-frequency (RF) energy collection module
(7) it is connected, and connect after Capacitance Coupled to data reception module (6)；Described rechargeable battery (4), radio-frequency (RF) energy collect mould
Block (7), microcontroller and micro- nerve stimulator module (5), data reception module (6), biological and temperature sensor (8) and pressure
Sensor (9) is from left to right successively and in the mutually isolated cavity being placed in described shell (1)；Described rechargeable battery (4)
Two power connections are connected to described radio-frequency (RF) energy collection module (7), micro-control by metallic bond zygonema successively in series
Device processed and micro- nerve stimulator module (5), data reception module (6), biological and temperature sensor (8) and pressure transducer (9)；
Described biology and the two paths of signals of temperature sensor (8) and a road signal of described pressure transducer (9) are connected to described number
According to receiver module (6)；Described microcontroller and micro- nerve stimulator module (5) also have two paths of signals to connect to described data receiver
Module (6)；It is additionally provided with for fixing described rechargeable battery (4), radio-frequency (RF) energy collection module in the cavity of described shell (1)
(7), microcontroller and micro- nerve stimulator module (5), data reception module (6), biological and temperature sensor (8) and pressure pass
The implant (11) of sensor (9)；Centerline hole and electrode (2) are further opened with the bulb of arbitrary in described 2 electrodes (2)
One eyelet (10) of axis perpendicular.
2. the injection nerve stimulator that radio-frequency (RF) energy according to claim 1 is powered, is characterized in that：Described shell (1)
Material be pottery or glass in any one.
3. the injection nerve stimulator that radio-frequency (RF) energy according to claim 1 is powered, is characterized in that：Described electrode (2)
For in platinum, platinum-iridium alloy, yttrium oxide, titanium nitride, silkworm silk any one.
4. the injection nerve stimulator that radio-frequency (RF) energy according to claim 1 is powered, is characterized in that：Described electrode (2)
Cylindrical diameter is less than the internal diameter of described shell (1)；The cylindrical bulb of described electrode (2) is with diameter greater than described electrode (2)
Cylindrical diameter.
5. the injection nerve stimulator that radio-frequency (RF) energy according to claim 1 is powered, is characterized in that：Described antenna
(3) it is metal micro-strip line.
6. the injection nerve stimulator that radio-frequency (RF) energy according to claim 1 is powered, is characterized in that：Described is chargeable
Battery (4) is the lithium ion battery with high-energy.
7. the injection nerve stimulator that radio-frequency (RF) energy according to claim 1 is powered, is characterized in that：Described implant
(11) it is any one in epoxy resin or gel.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510020720.9A CN104548344B (en) | 2015-01-16 | 2015-01-16 | Injection type nerve stimulator with power supplied by radio frequency energy |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510020720.9A CN104548344B (en) | 2015-01-16 | 2015-01-16 | Injection type nerve stimulator with power supplied by radio frequency energy |
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| CN104548344A CN104548344A (en) | 2015-04-29 |
| CN104548344B true CN104548344B (en) | 2017-02-22 |
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| US11038555B2 (en) * | 2018-08-06 | 2021-06-15 | Verily Life Sciences Llc | Systems and methods for enabling NFC communications with a wearable biosensor |
| WO2023097656A1 (en) * | 2021-12-03 | 2023-06-08 | Goertek Inc. | Proximity sensor, method for sensing proximity of wireless device and body part of user, and wireless device |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7054689B1 (en) * | 2000-08-18 | 2006-05-30 | Advanced Bionics Corporation | Fully implantable neurostimulator for autonomic nerve fiber stimulation as a therapy for urinary and bowel dysfunction |
| US20040010207A1 (en) * | 2002-07-15 | 2004-01-15 | Flaherty J. Christopher | Self-contained, automatic transcutaneous physiologic sensing system |
| CN101773701A (en) * | 2010-01-11 | 2010-07-14 | 杭州诺尔康神经电子科技有限公司 | Nerve stimulator |
| WO2014205407A2 (en) * | 2013-06-22 | 2014-12-24 | Micron Devices Llc | Methods and devices for the selective modulation of excitable tissue |
| CN104107507B (en) * | 2014-07-09 | 2016-06-08 | 庞德兴 | Passive Wicresoft underlying nerve based on RFID radio-frequency technique gets involved chip |
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Effective date of registration: 20201224 Address after: Room 206 (CNx), xifuhe digital intelligent innovation community Exhibition Center building, 49 Wengang South Road, Yannan high tech Zone, Yancheng City, Jiangsu Province Patentee after: Yancheng Yannan high tech Zone xifuhe digital intelligent industry development Co.,Ltd. Address before: Room 502-2, building 5, No. 49, Wengang South Road, Yannan high tech Zone, Yancheng City, Jiangsu Province 224000 (CNx) Patentee before: YANCHENG YIDONG TECHNOLOGY SERVICE Co.,Ltd. Effective date of registration: 20201224 Address after: Room 502-2, building 5, No. 49, Wengang South Road, Yannan high tech Zone, Yancheng City, Jiangsu Province 224000 (CNx) Patentee after: YANCHENG YIDONG TECHNOLOGY SERVICE Co.,Ltd. Address before: Meng Xi Road 212003 Zhenjiang city of Jiangsu province Jingkou District No. 2 Patentee before: JIANGSU University OF SCIENCE AND TECHNOLOGY |
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