CN104525149B - Middle molecule adsorbent for epidemic hemorrhagic fever and preparation method thereof - Google Patents
Middle molecule adsorbent for epidemic hemorrhagic fever and preparation method thereof Download PDFInfo
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- CN104525149B CN104525149B CN201410626140.XA CN201410626140A CN104525149B CN 104525149 B CN104525149 B CN 104525149B CN 201410626140 A CN201410626140 A CN 201410626140A CN 104525149 B CN104525149 B CN 104525149B
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- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/40—Aspects relating to the composition of sorbent or filter aid materials
- B01J2220/48—Sorbents characterised by the starting material used for their preparation
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Abstract
The invention discloses a kind of Middle molecule adsorbent for epidemic hemorrhagic fever and preparation method thereof, Middle molecule adsorbent includes the raw material of following weight portion meter: divinylbenzene 40～80 parts, poly hydroxy ethyl acrylate 30～60 parts, politef 40～80 parts, ethyl cellulose 30～60 parts, polystyrene 40～80 parts, magnesium oxide 50～70 parts, calcium oxide 90～120 parts, dalcium biphosphate 20～50 parts.Preparation method: divinylbenzene, poly hydroxy ethyl acrylate, politef, ethyl cellulose, polystyrene, magnesium oxide, calcium oxide, dalcium biphosphate mix homogeneously, reacts 1～2h under the conditions of 130～200 DEG C, 0.6～0.8kPa；Add ethyl cellulose, carry out heat treatment, under the conditions of 220～270 DEG C, 27～30kPa, finally react 3～8h.The present invention is used for treating epidemic hemorrhagic fever, can effectively adsorb Middle molecule, and clearance rate is high.
Description
Technical field
The present invention relates to biological medicine Material Field, particularly relate to a kind of Middle molecule adsorbent for epidemic hemorrhagic fever and system thereof
Preparation Method.
Background technology
Epidemic hemorrhagic fever, also known as hemorrhagic fever with renal syndrome, is the disease of natural focus caused by epidemic haemorrhagic fever virus, stream
Row is wide, and sb.'s sickness becomes critical, and case fatality rate is high, very harmful.Human beings worldwide's viral hemorrhagic fever has 13 kinds, according to this disease kidney
Have harmless, be divided into and have kidney to undermine without kidney damage two big classes.It is mainly hemorrhagic fever with renal syndrome (HFRS) in China.In pathogen
Before unresolved, claim epidemic hemorrhagic fever (EHF) in China, claim KHF (KHF) in Korea, weigh up blood in Russia
Property nephropathy nephritis (HNN).Due to specific serological diagnosis establishment and the solution of pathogen, nineteen eighty-two World Health Organization (WHO)
Unified by its named hemorrhagic fever with renal syndrome.Epidemic hemorrhagic fever is the acute infectious disease that virus causes.Cardinal symptom have heating,
Hemorrhage and kidney damage etc..Source of infection rural area mainly Apodemus agrarius, city are Rattus norvegicuss.Route of transmission determines the most completely,
May be relevant with the gamasid colonized in Mus, it is also possible to by sucking the dust of the pollutions such as saliva through Apodemus agrarius etc., urine excrement
And fall ill.Epidemic season is April to June (small peak) and October to December (peak).Distribute in crowd at ordinary times.Hemorrhage
Fever virus invades blood of human body, after 1～2 week incubation period, heating and poisoning symptom occurs, then causes whole body thin vessels and hair
Thin vascular lesion, blood plasma spills from the blood vessel wall of damage, pachyemia, circulation volume reduce, and produces hypotensive shock. blood vessel
Infringement, can cause each internal organs hemorrhage further.Albuminuria, oliguria and acute renal failure etc. are produced during renal blood vessels infringement,
Then nephridial tissue reparation, renal tubules new life, and renal tubules re-absorption function is not yet recovered, and thus results in polyuria.Above series of
Change relevant with the immunoreation of patient.
Medium molecular substance is one of major toxicity material of accumulation in patient with severe symptoms's blood such as epidemic hemorrhagic fever, is inhaled by Middle molecule
Attached dose of hemoperfusion removes the Middle molecule in blood samples of patients, is to alleviate and the effective ways for the treatment of epidemic hemorrhagic fever.
Summary of the invention
The present invention is directed to the deficiencies in the prior art, it is provided that a kind of Middle molecule adsorbent for epidemic hemorrhagic fever and preparation method thereof,
Effective for the Middle molecule adsorbent of epidemic hemorrhagic fever, clearance rate is high.
In order to solve above-mentioned technical problem, the present invention by the following technical solutions:
For the Middle molecule adsorbent of epidemic hemorrhagic fever, including the raw material of following weight portion meter: divinylbenzene 40～80 parts,
Poly hydroxy ethyl acrylate 30～60 parts, politef 40～80 parts, ethyl cellulose 30～60 parts, polystyrene
40～80 parts, magnesium oxide 50～70 parts, calcium oxide 90～120 parts, dalcium biphosphate 20～50 parts.
As to further improvement of the present invention, for the Middle molecule adsorbent of epidemic hemorrhagic fever, including following weight portion meter
Raw material: divinylbenzene 60 parts, poly hydroxy ethyl acrylate 50 parts, politef 60 parts, ethyl cellulose 40 parts,
Polystyrene 60 parts, magnesium oxide 60 parts, calcium oxide 100 parts, dalcium biphosphate 30 parts.
As to further improvement of the present invention, the particle diameter of magnesium oxide is 80～100 μm.
As to further improvement of the present invention, the particle diameter of calcium oxide is 40～100 μm.
Present invention also offers the preparation method of a kind of Middle molecule adsorbent for epidemic hemorrhagic fever.
The preparation method of a kind of Middle molecule adsorbent for epidemic hemorrhagic fever, comprises the following steps: divinylbenzene, poly-first
Base 2-(Acryloyloxy)ethanol, politef, ethyl cellulose, polystyrene, magnesium oxide, calcium oxide, dalcium biphosphate mix
Uniformly, 1～2h is reacted under the conditions of 130～200 DEG C, 0.6～0.8kPa；Add ethyl cellulose, carry out heat treatment, finally exist
3～8h are reacted under the conditions of 220～270 DEG C, 27～30kPa.
As to further improvement of the present invention, heat treatment temperature is 400～800 DEG C, and the time is 20～40min.
Beneficial effect: the present invention is used for treating epidemic hemorrhagic fever, can effectively adsorb Middle molecule, and clearance rate is high, be 63.4～
67.3%, this is because politef can significantly improve the adsorption effect of Middle molecule adsorbent.And the Middle molecule of the present invention is inhaled
Attached dose is applied to treat epidemic hemorrhagic fever good effect, Middle molecule adsorbent and blood dialysis therapeutic alliance epidemic hemorrhagic fever
Mortality rate substantially reduces.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described.
Embodiment 1
For the Middle molecule adsorbent of epidemic hemorrhagic fever, including the raw material of following weight portion meter: divinylbenzene 60 parts, poly-first
Base 2-(Acryloyloxy)ethanol 50 parts, politef 60 parts, ethyl cellulose 40 parts, polystyrene 60 parts, magnesium oxide 60 parts,
Calcium oxide 100 parts, dalcium biphosphate 30 parts.
The particle diameter of magnesium oxide is 90 μm.
The particle diameter of calcium oxide is 70 μm.
The preparation method of a kind of Middle molecule adsorbent for epidemic hemorrhagic fever, comprises the following steps: divinylbenzene, poly-first
Base 2-(Acryloyloxy)ethanol, politef, ethyl cellulose, polystyrene, magnesium oxide, calcium oxide, dalcium biphosphate mix
Uniformly, 150 DEG C, react 1.5h under the conditions of 0.7kPa；Add ethyl cellulose, carry out heat treatment, finally at 250 DEG C, 28kPa
Under the conditions of react 5h.
Heat treatment temperature is 600 DEG C, and the time is 30min.
Embodiment 2
For the Middle molecule adsorbent of epidemic hemorrhagic fever, including the raw material of following weight portion meter: divinylbenzene 40 parts, poly-first
Base 2-(Acryloyloxy)ethanol 30 parts, politef 40 parts, ethyl cellulose 30 parts, polystyrene 40 parts, magnesium oxide 50 parts,
Calcium oxide 90 parts, dalcium biphosphate 20 parts.
The particle diameter of magnesium oxide is 80 μm.
The particle diameter of calcium oxide is 40 μm.
The preparation method of a kind of Middle molecule adsorbent for epidemic hemorrhagic fever, comprises the following steps: divinylbenzene, poly-first
Base 2-(Acryloyloxy)ethanol, politef, ethyl cellulose, polystyrene, magnesium oxide, calcium oxide, dalcium biphosphate mix
Uniformly, 130 DEG C, react 1h under the conditions of 0.6kPa；Add ethyl cellulose, carry out heat treatment, finally at 220 DEG C, 27kPa
Under the conditions of react 3h.
Heat treatment temperature is 400 DEG C, and the time is 20min.
Embodiment 3
For the Middle molecule adsorbent of epidemic hemorrhagic fever, including the raw material of following weight portion meter: divinylbenzene 80 parts, poly-first
Base 2-(Acryloyloxy)ethanol 60 parts, politef 80 parts, ethyl cellulose 60 parts, polystyrene 80 parts, magnesium oxide 70 parts,
Calcium oxide 120 parts, dalcium biphosphate 50 parts.
The particle diameter of magnesium oxide is 100 μm.
The particle diameter of calcium oxide is 100 μm.
The preparation method of a kind of Middle molecule adsorbent for epidemic hemorrhagic fever, comprises the following steps: divinylbenzene, poly-first
Base 2-(Acryloyloxy)ethanol, politef, ethyl cellulose, polystyrene, magnesium oxide, calcium oxide, dalcium biphosphate mix
Uniformly, 200 DEG C, react 2h under the conditions of 0.8kPa；Add ethyl cellulose, carry out heat treatment, finally at 270 DEG C, 30kPa
Under the conditions of react 8h.
Heat treatment temperature is 800 DEG C, and the time is 40min.
Comparative example 1
Same as in Example 1, difference is: be not added with politef.
Performance test
Measure embodiment and the properties of product of comparative example, the results are shown in Table 1.
Table 1
| Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | |
| Middle molecule adsorption rate % | 67.3 | 63.4 | 66.8 | 43.2 |
The Middle molecule adsorbent of embodiment 1 is used for treating the mortality rate of epidemic hemorrhagic fever.The results are shown in Table 2.
Table 2
Experimental group: the Middle molecule adsorbent of embodiment 1 and blood dialysis therapeutic alliance epidemic hemorrhagic fever, observes mortality rate.
Matched group: blood dialysis treatment epidemic hemorrhagic fever, observes mortality rate.
| Experimental group | 6.8% |
| Matched group | 18.3% |
Conclusion: the present invention is used for treating epidemic hemorrhagic fever, can effectively adsorb Middle molecule, and clearance rate is high, is 63.4～67.3%,
Do not add the clearance rate only 43.2% of the Middle molecule adsorbent of politef, illustrate that politef can significantly improve Middle molecule and inhale
The adsorption effect of attached dose.And the Middle molecule adsorbent of the present invention and the mortality rate of blood dialysis therapeutic alliance epidemic hemorrhagic fever
Substantially reduce, illustrate that this Middle molecule adsorbent is applied to treat epidemic hemorrhagic fever good effect.
Claims (5)
1. for the Middle molecule adsorbent of epidemic hemorrhagic fever, it is characterized in that, including the raw material of following weight portion meter: divinylbenzene 40～80 parts, poly hydroxy ethyl acrylate 30～60 parts, politef 40～80 parts, ethyl cellulose 30～60 parts, polystyrene 40～80 parts, magnesium oxide 50～70 parts, calcium oxide 90～120 parts, dalcium biphosphate 20～50 parts；Its preparation method comprises the following steps: divinylbenzene, poly hydroxy ethyl acrylate, politef, ethyl cellulose, polystyrene, magnesium oxide, calcium oxide, dalcium biphosphate mix homogeneously, reacts 1～2h under the conditions of 130～200 DEG C, 0.6～0.8kPa；Add ethyl cellulose, carry out heat treatment, under the conditions of 220～270 DEG C, 27～30kPa, finally react 3～8h.
Middle molecule adsorbent for epidemic hemorrhagic fever the most according to claim 1, it is characterized in that, including the raw material of following weight portion meter: divinylbenzene 60 parts, poly hydroxy ethyl acrylate 50 parts, politef 60 parts, ethyl cellulose 40 parts, polystyrene 60 parts, magnesium oxide 60 parts, calcium oxide 100 parts, dalcium biphosphate 30 parts.
Middle molecule adsorbent for epidemic hemorrhagic fever the most according to claim 1, it is characterised in that the particle diameter of magnesium oxide is 80～100 μm.
Middle molecule adsorbent for epidemic hemorrhagic fever the most according to claim 1, it is characterised in that the particle diameter of calcium oxide is 40～100 μm.
Middle molecule adsorbent for epidemic hemorrhagic fever the most according to claim 1, it is characterised in that heat treatment temperature is 400～800 DEG C, the time is 20～40min.
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| CN101177265A (en) * | 2007-11-13 | 2008-05-14 | 南京大学 | Mesopore spherical activated carbon and preparation method thereof |
| CN101824117A (en) * | 2010-02-04 | 2010-09-08 | 中南大学 | Chelate resin immobilized with dendrimer and preparation method thereof |
| CN102049242A (en) * | 2011-01-08 | 2011-05-11 | 广州康盛生物科技有限公司 | Anion resin for bilirubin absorption and preparation method thereof |
| CN102221585A (en) * | 2010-04-16 | 2011-10-19 | 中国科学院大连化学物理研究所 | Application method of magnesium oxide microsphere in environmental water sample |
| CN102423687A (en) * | 2011-08-08 | 2012-04-25 | 重庆希尔康血液净化器材研发有限公司 | Preparation method of resin carbon for blood purification |
| CN102725008A (en) * | 2009-08-07 | 2012-10-10 | 汉莫堤克股份有限公司 | Device and method for eliminating biologically harmful substances from bodily fluids |
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Patent Citations (8)
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| WO2004025268A3 (en) * | 2002-09-13 | 2004-11-25 | Univ Carnegie Mellon | Optical biosensors and methods of use thereof |
| CN101058068A (en) * | 2007-05-31 | 2007-10-24 | 浙江工商大学 | Macroporous adsorption resin special used for separating antibiotic and its preparation method |
| CN101177265A (en) * | 2007-11-13 | 2008-05-14 | 南京大学 | Mesopore spherical activated carbon and preparation method thereof |
| CN102725008A (en) * | 2009-08-07 | 2012-10-10 | 汉莫堤克股份有限公司 | Device and method for eliminating biologically harmful substances from bodily fluids |
| CN101824117A (en) * | 2010-02-04 | 2010-09-08 | 中南大学 | Chelate resin immobilized with dendrimer and preparation method thereof |
| CN102221585A (en) * | 2010-04-16 | 2011-10-19 | 中国科学院大连化学物理研究所 | Application method of magnesium oxide microsphere in environmental water sample |
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Inventor after: Qiu Caijun Inventor before: Pan Lingen Inventor before: Qiu Dongcheng Inventor before: Liu Lefeng |
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Effective date of registration: 20160905 Address after: 312400 Zhejiang city of Shaoxing province Shengzhou City Zhijie Lake Yan North Street No. 108 commercial city building 6 room 613 Applicant after: Zhejiang Yicheng industrial product design Co., Ltd. Address before: Wuzhong District town Suzhou city Jiangsu province 215101 gold Jinchang Road No. 360 Applicant before: Suzhou Vivotide Biotechnologies Co., Ltd. |
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Effective date of registration: 20171213 Address after: 225500 south side of Tongyang West Road, Jiangyan Economic Development Zone, Taizhou City, Jiangsu Province Patentee after: Taizhou Qida coating Auxiliaries Co., Ltd. Address before: 312400 Zhejiang city of Shaoxing province Shengzhou City Zhijie Lake Yan North Street No. 108 commercial city building 6 room 613 Patentee before: Zhejiang Yicheng industrial product design Co., Ltd. |