CN104399281A - Liquid flow controller for radial chromatographic column - Google Patents
Liquid flow controller for radial chromatographic column Download PDFInfo
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- CN104399281A CN104399281A CN201410778200.XA CN201410778200A CN104399281A CN 104399281 A CN104399281 A CN 104399281A CN 201410778200 A CN201410778200 A CN 201410778200A CN 104399281 A CN104399281 A CN 104399281A
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- control panel
- liquid flow
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- type guiding
- water conservancy
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Abstract
The invention relates to a liquid flow controller for a radial chromatographic column. The liquid flow controller comprises a control plate, a sleeve plate and a draft tube, wherein one end face of the control plate is regularly provided with a plurality of H-shaped diversion grooves, each H-shaped diversion groove is longitudinally arranged, and four end corners of each H-shaped diversion groove are provided with through holes communicated with the other end face of the control plate; the H-shaped diversion grooves are mutually communicated through a lying transverse H-shaped groove, the sleeve plate is adhered to the end face, on which the H-shaped diversion grooves are arranged, of the control plate, the draft tube is communicated with the H-shaped diversion grooves, and the sleeve plate is integrated with the control plate into a whole body and then is provided with a cylinder structure; due to arrangement of the H-shaped diversion grooves on the control plate, the distance of liquid flow between an inlet and each outlet is completely equal to the section area of passing liquid flow. The liquid flow resistances are completely equal to each other, so that the transmission time, the flow rate and the pressure of a mobile phase are guaranteed to be consistent. The liquid flow controller for the radial chromatographic column can be suitable for liquid flow control of an industrial large-diameter radial chromatographic column, and the defect that the resistance times of a mobile phase on a liquid flow distribution system are seriously difference along with the diameter increasing of the radial chromatographic column is effectively eliminated.
Description
Technical field
The invention belongs to the association area of the liquid flow control technology of radial chromatographic column in pharmaceuticals industry separation and purification system, is a kind ofly be applicable to the flow direction of mobile phase and the fluid control apparatus of assignment of traffic in large diameter cylindrical shape radial chromatography post specifically.
Background technology
Chromatographic column is the vitals of preparing chromatograph in industry, and major function is separation from liquefied mixture, obtains pure material.In actual production; in order to accelerate the disengaging time of material; improve separative efficiency; preparative chromatography device to enter sample size very large; cause the corresponding increasing of the segregational load of preparative chromatography post; the material that often there will be a large amount of strong absorption remains in separating medium, pollutes chromatography column packing, shortens the service life of chromatographic column.In preparative chromatography device, add radial chromatography post, the material that rejected in advance adsorbs by force is a kind of very effective process.
In use, the liquid flow path direction of radial chromatography post and flow can directly have influence on its effect.Such as: it is improper that shortage controls or controls, and mobile phase by medium in whole post, can cause the waste of medium in post, and the price of this medium is not expensive.
The liquid flow control technology that the radial chromatography post applied in the lab adopts injects mobile phase by the polytetrafluoroethylene sleeve of porous to the separating medium in sintering sieve plate sleeve.But comparatively large for diameter, the especially radial chromatography post of industrial production, above way is difficult to the uniform distribution realizing mobile phase.
Summary of the invention
The invention provides a kind of fluid control apparatus of radial chromatography post, it can be applicable to the liquid current control of industrial major diameter radial chromatography post, the residence time of effective elimination mobile phase on liquid flow sharing system has the defect of significant differences with the increase of radial chromatography column diameter, realize the even original allocation entering radial chromatography post interior media mobile phase, and mobile phase high pressure conveying impact can not be subject to.The structural design of this fluid control apparatus is simple, not easily blocks, easily cleaning and Reusability.
The present invention solves the technical scheme that its technical problem takes: a kind of fluid control apparatus of radial chromatography post, comprises control panel, sleeve plate and mozzle;
Regularly spread configuration multiple H type guiding gutter on an end face of described control panel, each H type guiding gutter is longitudinally arranged, and arranges at the quadripolar corners of each H type guiding gutter the other end that through hole is communicated to described control panel;
Form a water conservancy diversion module by every four by adjacent H type guiding gutter, and four H type guiding gutters in each water conservancy diversion module are communicated to respective transverse center position by " work " font groove lain low;
Described control panel end face is established eight water conservancy diversion modules altogether, and every mutually by adjacent four water conservancy diversion module compositions one group, and symmetrical about the longitudinal center's broken line on control panel end face;
Four water conservancy diversion modules often in group are communicated to respective transverse center position by " work " font groove lain low;
Cylinder groove is established in the end face center being provided with H type guiding gutter at control panel, and longitudinally establishes two groups of water conservancy diversion modules described in the connection of yi word pattern groove to two ends centered by described cylinder groove;
At the center of described sleeve plate, central through hole is set;
Described sleeve plate is fitted in described control panel establish on an end face of H type guiding gutter, described central through hole is coaxially corresponding with described cylinder groove, and described mozzle one end is connected in described cylinder groove through described central through hole;
Described sleeve plate and described control panel are longitudinally set to tubular and link are sealed after fitting into one and be connected.
316L material adopted by described sleeve plate, and described control panel adopts polytetrafluoroethylene (PTFE) material.
The invention has the beneficial effects as follows: molding structure of the present invention is tubular, but takes plane form when fabrication design, reduces manufacture difficulty.By the spread configuration of H type guiding gutter on control panel, after liquid stream is entered by cylinder groove, circulation is carried out longitudinally, horizontal equalization shunting, eventually passes through and arranges that uniform fluid outlet (through hole namely on control panel) is injected in separating medium with identical pressure with identical flow.The flow cross-section that liquid stream passes through from each entrance to the Distance geometry that each exports is long-pending completely equal.Liquid flowing resistance is completely equal, ensure that the mobile phase transmission time, flow, pressure identical.So, it can be applicable to the liquid current control of industrial major diameter radial chromatography post, the residence time of effective elimination mobile phase on liquid flow sharing system has the defect of significant differences with the increase of radial chromatography column diameter, realize the even original allocation entering radial chromatography post interior media mobile phase, and mobile phase high pressure conveying impact can not be subject to.In addition its structural design is simple, not easily blocks, easily cleaning and Reusability.
Accompanying drawing explanation
Fig. 1 is the structural representation of the both ends of the surface of control panel in the present invention;
Fig. 2 is the structural representation of single H type guiding gutter on control panel in the present invention;
Fig. 3 is the status architecture schematic diagram in the present invention in control panel and sleeve plate connection procedure;
Fig. 4 is structural representation when control panel and sleeve plate connect as one in the present invention;
In figure: 1 control panel, 11H type guiding gutter, 111 cannelures, 12 cylinder grooves, 13 through holes, 2 sleeve plates, 3 mozzles.
Detailed description of the invention
For ease of understanding technical scheme of the present invention, below in conjunction with accompanying drawing, wherein involved technology contents is described further.
In the description of this invention, it should be noted that, term "left", "right", " on ", D score, " interior ", the orientation of the instruction such as " outward " or position relationship be based on orientation shown in the drawings or position relationship, only the present invention for convenience of description and simplified characterization, instead of indicate or imply that the device of indication or element must have specific orientation, with specific azimuth configuration and operation, therefore can not be interpreted as limitation of the present invention.
In describing the invention, it should be noted that, unless otherwise clearly defined and limited, term " installation ", " being connected ", " connection " should be interpreted broadly, and such as, can be fixedly connected with, also can be removably connect, or connect integratedly; Can be mechanical connection, also can be electrical connection, can be directly to be connected, and also indirectly can be connected by intermediary, can be the connection of two element internals.For the ordinary skill in the art, concrete condition above-mentioned term concrete meaning in the present invention can be understood.
As shown in Figures 1 to 4:
A fluid control apparatus for radial chromatography post, comprises control panel 1, sleeve plate 2 and mozzle 3.
Regularly spread configuration 32 H type guiding gutters 11 on an end face of described control panel 1, each H type guiding gutter 11 longitudinally (upward and downward) is arranged, and namely the cannelure 111 of H type guiding gutter 11 extends along the vertical direction.At the quadripolar corners (two ends of each cannelure 111) of each H type guiding gutter 11, the other end that through hole 13 is communicated to described control panel 1 is set.
Form a water conservancy diversion module by every four by adjacent H type guiding gutter 11, and four H type guiding gutters 11 in each water conservancy diversion module are communicated to respective transverse center position by " work " font groove lain low.
Described control panel 1 end face eight water conservancy diversion modules have been established altogether, and it is every mutually by adjacent four water conservancy diversion module compositions one group, and symmetrical about the longitudinal center's broken line on control panel 1 end face, i.e. four water conservancy diversion module compositions one group of upper end, four water conservancy diversion module compositions one group of lower end.
Be communicated to the transverse center position of each water conservancy diversion module by arranging " work " font groove lain low between four water conservancy diversion modules of upper end.In like manner, the same upper end of mode of communicating between four water conservancy diversion modules of lower end.
Cylinder groove 12 is established in the end face center being provided with H type guiding gutter at control panel 1, and longitudinally establishes the two groups of water conservancy diversion modules being positioned at upper and lower end described in the connection of yi word pattern groove to two ends centered by described cylinder groove 12.
Arrange central through hole at the center of described sleeve plate 2,316L material adopted by described sleeve plate.
Described control panel 1 adopts polytetrafluoroethylene (PTFE) material.
Described sleeve plate 2 is fitted in described control panel 1 establish on an end face of H type guiding gutter 11, the end of Yao Shi edge and grooved upper end all seals laminating, thus makes each H type guiding gutter 11 and each H type guiding gutter communication groove each other form seal groove.Described central through hole is coaxial corresponding with described cylinder groove 12, and described mozzle 3 one end is connected in described cylinder groove 12 through described central through hole.Finally, be longitudinally set to tubular (namely the girth of tubular equals the longitudinal length of sleeve plate 2 or control panel 1) and link is sealed after described sleeve plate 2 and described control panel 1 being fitted into one and be connected.After liquid is entered by this cylindrical body, cylinder groove 12 place entered on described control panel 1 through described mozzle 3 starts once to shunt, as shown in Figure 1, stream two is punished by cylinder groove 12, enter in upper and lower two groups of H type guiding gutters 11, second diffluence is carried out in both sides to the left and right, finally carrying out three shuntings again enters in each independently water conservancy diversion module, each independently H type guiding gutter 11 is entered carrying out twice shunting in an independently water conservancy diversion module, the flow direction in H type guiding gutter 11 as shown in Figure 2, finally flowed out by the through hole 13 on H type guiding gutter 11, be injected in separating medium with identical pressure with identical flow.The flow cross-section that the Distance geometry that liquid stream exports from cylinder groove 12 porch to each through hole 13 passes through is long-pending completely equal.Liquid flowing resistance is also completely equal, ensure that the mobile phase transmission time, flow, pressure identical.So, it can be applicable to the liquid current control of industrial major diameter radial chromatography post, the residence time of effective elimination mobile phase on liquid flow sharing system has the defect of significant differences with the increase of radial chromatography column diameter, realize the even original allocation entering radial chromatography post interior media mobile phase, and mobile phase high pressure conveying impact can not be subject to.In addition its structural design is simple, not easily blocks, easily cleaning and Reusability.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the technology of the present invention principle; can also make some improvement and modification, these improve and modification also should be considered as protection scope of the present invention.
Except the technical characteristic described in description, be the known technology of those skilled in the art.
Claims (2)
1. a fluid control apparatus for radial chromatography post, is characterized in that:
Comprise control panel, sleeve plate and mozzle;
Regularly spread configuration multiple H type guiding gutter on an end face of described control panel, each H type guiding gutter is longitudinally arranged, and arranges at the quadripolar corners of each H type guiding gutter the other end that through hole is communicated to described control panel;
Form a water conservancy diversion module by every four by adjacent H type guiding gutter, and four H type guiding gutters in each water conservancy diversion module are communicated to respective transverse center position by " work " font groove lain low;
Described control panel end face is established eight water conservancy diversion modules altogether, and every mutually by adjacent four water conservancy diversion module compositions one group, and symmetrical about the longitudinal center's broken line on control panel end face;
Four water conservancy diversion modules often in group are communicated to respective transverse center position by " work " font groove lain low;
Cylinder groove is established in the end face center being provided with H type guiding gutter at control panel, and longitudinally establishes two groups of water conservancy diversion modules described in the connection of yi word pattern groove to two ends centered by described cylinder groove;
At the center of described sleeve plate, central through hole is set;
Described sleeve plate is fitted in described control panel establish on an end face of H type guiding gutter, described central through hole is coaxially corresponding with described cylinder groove, and described mozzle one end is connected in described cylinder groove through described central through hole;
Described sleeve plate and described control panel are longitudinally set to tubular and link are sealed after fitting into one and be connected.
2. the fluid control apparatus of radial chromatography post according to claim 1, is characterized in that: 316L material adopted by described sleeve plate, and described control panel adopts polytetrafluoroethylene (PTFE) material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410778200.XA CN104399281A (en) | 2014-12-15 | 2014-12-15 | Liquid flow controller for radial chromatographic column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410778200.XA CN104399281A (en) | 2014-12-15 | 2014-12-15 | Liquid flow controller for radial chromatographic column |
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| Publication Number | Publication Date |
|---|---|
| CN104399281A true CN104399281A (en) | 2015-03-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410778200.XA Pending CN104399281A (en) | 2014-12-15 | 2014-12-15 | Liquid flow controller for radial chromatographic column |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101023346A (en) * | 2004-09-08 | 2007-08-22 | 拜尔技术服务有限责任公司 | Liquid distributor and liquid collector for chromatography columns |
| CN101632878A (en) * | 2009-09-01 | 2010-01-27 | 北京创新通恒科技有限公司 | Distribution method and distribution device of mobile phases of chromatographic columns |
| CN201643783U (en) * | 2009-12-22 | 2010-11-24 | 大连依利特分析仪器有限公司 | Multi-hole grooved distribution disc for making chromatographic column heads |
| CN204428893U (en) * | 2014-12-15 | 2015-07-01 | 聊城万合工业制造有限公司 | The fluid control apparatus of radial chromatography post |
-
2014
- 2014-12-15 CN CN201410778200.XA patent/CN104399281A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101023346A (en) * | 2004-09-08 | 2007-08-22 | 拜尔技术服务有限责任公司 | Liquid distributor and liquid collector for chromatography columns |
| CN101632878A (en) * | 2009-09-01 | 2010-01-27 | 北京创新通恒科技有限公司 | Distribution method and distribution device of mobile phases of chromatographic columns |
| CN201643783U (en) * | 2009-12-22 | 2010-11-24 | 大连依利特分析仪器有限公司 | Multi-hole grooved distribution disc for making chromatographic column heads |
| CN204428893U (en) * | 2014-12-15 | 2015-07-01 | 聊城万合工业制造有限公司 | The fluid control apparatus of radial chromatography post |
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Application publication date: 20150311 |