CN104306513A - Production technology of female external care solution - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/234—Cnidium (snowparsley)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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Abstract
The invention discloses a production technology of a female external care solution. The production technology comprises the following steps: respectively weighing common cnidium fruit, radix sophorae flavescentis, Chinese mosla herb, honeysuckle, Chinese prickly ash, Chinese pulsatilla root and scutellaria baicalensis by a ratio by weight, pulverizing and mixing into a raw material mixture; carrying out enzymatic hydrolysis reaction on the pulverized raw material mixture and cellulose, carrying out ultrasonic heating and digestion after finishing enzymatic hydrolysis reaction, and recovering an extracting solution; carrying primary purification treatment on the extracting solution, then adding water to dilute, and uniformly mixing with a surfactant, a PH regulator and borneol to prepare a care solution semi-finished product; carrying out sterilizing treatment and secondary purification treatment on the care solution semi-finished product. In the invention, enzymatic hydrolysis is first carried out, and then, ultrasonic heating and digestion, primary purification, mixing and proportioning and nitrogen introduction purification treatment are carried out. The whole technical process is simple, active components in the raw materials can be effectively extracted and utilized, the raw material utilizing rate is improved, and the production cost is reduced.
Description
Technical field
The present invention relates to feminine care products field, be specifically related to a kind of production technology of female nursing solution for external use.
Background technology
In recent years; along with the development of personal care articles; the enhancing of consumer's self health consciousness; also more and more higher to the requirement of nursing product self; not only be satisfied with its some the most basic functions; also wish that new utilitarian function served by band; especially the care product of women's specific skin; except there is the effect of basic protection skin; also wish that it can clean, sterilize, deodorization, antiinflammatory, antipruritic, prevent some skin problems from occurring etc., this be also personal nursing development a new trend.
Female nursing solution for external use is Precerving liquid conventional in a kind of daily life, and primary efficacy is to regulate pH value, clean and sterilization, the effect of some Feminine care solution also containing " beauty treatment ".Existing Feminine care solution mainly contains two classes, and one is: the medicinal lotion with disease therapy function, and this kind of lotion often forms by multiple extracts of Chinese herbal medicine is composite, and its Main Function is to treat various gynaecopathia, plays medicinal efficacy; It two is: the Feminine care solution with sterilization and cleaning function, and it mainly will divide is play the surfactant of cleaning action and play the antibacterial of bactericidal action, and its Main Function is clean and sterilizes.
At present, for its mainly simple alcohol extraction of extraction of extracts of Chinese herbal medicine composite class female nursing solution for external use, the method not only makes the extraction ratio of effective ingredient in Chinese herbal medicine low, also cause the unnecessary waste of the lixiviate slag containing mass efficient composition, and it extracts solvent alcohol in the extracting solution that obtains and is difficult to be completely removed, therefore cause the complexity of subsequent operation operation, make whole production cost high.
Summary of the invention
The object of the present invention is to provide a kind of production technology of female nursing solution for external use, it can effectively extract by the effective ingredient in Chinese herbal medicine, and whole production technology is simple simultaneously, and the female nursing solution for external use simultaneously produced has antiinflammatory, antipruritic, clean effect.
For achieving the above object, the present invention operates by the following technical solutions:
A production technology for female nursing solution for external use, specifically comprises the steps:
S1: take Fructus Cnidii by weight 1:1.2 ~ 1.4:1.2 ~ 1.7:0.5 ~ 0.8:1.2 ~ 1.4:1 ~ 1.4:0.2 ~ 0.4 respectively, Radix Sophorae Flavescentis, Herba Moslae, Flos Lonicerae, Pericarpium Zanthoxyli, the Radix Pulsatillae, Radix Scutellariae carry out fragmentation and be mixed into mixed material;
S2: the mixed material after fragmentation and cellulase are carried out enzyme digestion reaction, is undertaken mixing Ultrasonic Heating lixiviate by enzymolysis solution and aqueous solution after enzyme digestion reaction terminates, carries out sedimentation and filtration after Ultrasonic Heating lixiviate to mixed liquor, reclaims extracting solution;
S3 a: purification process is carried out to extracting solution, then thin up carry out mixing with surfactant and PH regulator, Borneolum Syntheticum to be made into PH be 5.0 ~ 5.5 semi-finished product conditioning liquids;
S4: semi-finished product conditioning liquid carried out sterilization treatment, be then placed in an aseptic still, the sterile nitrogen bubble entering 50 ~ 100um from still pucking carries out secondarily purified process, removing mixed liquor blibbing layer.
Further scheme is:
In step S3, extracting solution, water carry out joining getting according to volume ratio 1:8, in the semi-finished product extracting solution of configuration, content of bornyl alcohol is 5.5 ~ 6.0g/L, in semi-finished product extracting solution, the content of surfactant is 75 ~ 85g/L, the density of extracting solution is 1.5 ~ 1.6g/ml, and described surfactant is that dodecyldimethylammonium hydroxide inner salt and cocoamidopropyl dimethylamine amine second lactone are formed by weight 1:1 mixing.
PH regulator in step S3 is that lactic acid and phosphoric acid are formulated.
In step S2, the temperature of enzyme digestion reaction is 48 DEG C, and pH value is 6.5, and enzymolysis time is 80min, and the concentration of enzyme digestion reaction mixed liquor cellulase is 2.5 ~ 2.8ul/L.
In step S3, a purification process utilizes micro-filtration membrane to filter, and micro-filtration membrane used is polyvinylidene fluoride microporous filtering film.
In step S2, Ultrasonic Heating lixiviate adds the aqueous solution of 100 ~ 150ml according to every 10g mixed material powder, and the temperature of Ultrasonic Heating lixiviate is 45 ~ 50 DEG C, time 20 ~ 30min.
By long term test, on the basis realizing the object of the invention, the result of use of the female nursing solution for external use that following prioritization scheme is produced can be improved significantly, and its antiinflammatory, antipruritic curative effect phase can effectively shorten, and this prioritization scheme is specific as follows:
Fructus Cnidii in step S1, Radix Sophorae Flavescentis, Herba Moslae, Flos Lonicerae, Pericarpium Zanthoxyli, the Radix Pulsatillae, Radix Scutellariae take respectively by weight 1:1.2:1.5:0.5:1.2:1:0.2 and carry out fragmentation and be mixed into mixed material;
In step S3, in semi-finished product extracting solution, the content of surfactant is 80g/L, and content of bornyl alcohol is 5.5g/L, and the density of extracting solution is 1.5g/ml.
By first carrying out enzymolysis in the present invention, then Ultrasonic Heating lixiviate, purification, mixing preparation and an inflated with nitrogen purification process is carried out, whole technological process is simple, and the active component in raw material can be made to be efficiently extracted by the rankine steam cycle and to utilize, and improves the utilization rate of raw material and reduces production cost.Meanwhile, by twice purification process, effectively can prevent obtained female nursing solution for external use from occurring deposited phenomenon, improve retention cycle.In addition, select Fructus Cnidii, Radix Sophorae Flavescentis, Herba Moslae, Flos Lonicerae, Pericarpium Zanthoxyli, the Radix Pulsatillae, Radix Scutellariae as raw material in the present invention, Fructus Cnidii, Radix Sophorae Flavescentis, Herba Moslae, Flos Lonicerae, Pericarpium Zanthoxyli, the Radix Pulsatillae, Radix Scutellariae all have antiinflammatory, antipruritic effect, as Herba Moslae, it has the pharmacological actions such as expelling insect and relieving itching, spectrum antibacterial, antiinflammatory, enhancing immunity, and can eliminate abnormal flavour; Radix Sophorae Flavescentis, it has heat clearing and damp drying, parasite killing, diuresis, effect for the treatment of eczema, eczema, skin pruritus; Pericarpium Zanthoxyli, medication is with a long history, and after the Qing Dynasty, its pain relieving insecticidal action is used widely in clinical; There is inhibitory action in various degree to antibacterial, fungus, have and kill infusorian effect significantly; Therefore by the synergism that above-mentioned raw materials combination of components produces, thus make obtained female nursing solution for external use have good sterilization, antiinflammatory, clean, moisten, the effect of nursing; This conditioning liquid has broad-spectrum antibacterial, parasite killing, inflammation-resisting itch-stopping and clean external genital effect, thus reaches the Multifunctional effect for the treatment of both the principal and secondary aspects of a disease, and the side effect such as non-stimulated, irritated.
Detailed description of the invention
Below by way of specific embodiment, the invention will be further described.Wherein in embodiment 1 ~ 3, described surfactant is that dodecyldimethylammonium hydroxide inner salt and cocoamidopropyl dimethylamine amine second lactone are formed by weight 1:1 mixing, and PH regulator is that lactic acid and phosphoric acid are formulated.Wherein each concentration of component of the PH regulator that embodiment 1 ~ 3 is used is inconsistent, and it is final PH according to the Feminine care solution of required configuration and determines.
Embodiment 1
Take Fructus Cnidii respectively by weight 1:1.2:1.5:0.8:1.2:1.3:0.4, Radix Sophorae Flavescentis, Herba Moslae, Flos Lonicerae, Pericarpium Zanthoxyli, the Radix Pulsatillae, Radix Scutellariae carry out fragmentation and be mixed into 100 object mixed materials;
Mixed material after fragmentation and cellulase are carried out enzyme digestion reaction, and the temperature of controlled enzymatic hydrolysis reaction is 48 DEG C, and pH value is 6.5, and enzymolysis time is 80min, and the concentration of enzyme digestion reaction mixed liquor cellulase is 2.8ul/L.Enzymolysis solution and aqueous solution are carried out mixing Ultrasonic Heating lixiviate after enzyme digestion reaction terminates, Ultrasonic Heating lixiviate adds the aqueous solution of 100ml according to every 10g mixed material powder, and the temperature of Ultrasonic Heating lixiviate is 50 DEG C, time 20min.After Ultrasonic Heating lixiviate, centrifugation is carried out to mixed liquor, after centrifugation, carry out filter pressing, carrying out secondary filter after filter pressing, after secondary filter, be condensed into the extracting solution of 1.6g/ml;
Utilize polyvinylidene fluoride microporous filtering film to carry out microfiltration process to extracting solution, reclaim filtrate, then thin up carry out mixing with surfactant and PH regulator, Borneolum Syntheticum to be made into PH be 5.5 semi-finished product conditioning liquids; Wherein extracting solution, water carry out joining getting according to volume ratio 1:8, and in the semi-finished product extracting solution of configuration, content of bornyl alcohol is 5.5g/L, and in semi-finished product extracting solution, the content of surfactant is 85g/L.
Semi-finished product conditioning liquid carried out sterilization treatment, be then placed in an aseptic still, the sterile nitrogen bubble entering 50 ~ 100um from still pucking carries out secondarily purified process, can obtain female nursing solution for external use after removing mixed liquor blibbing layer.
Embodiment 2
Take Fructus Cnidii respectively by weight 1:1.2:1.4:0.8:1.2:1.2:0.2, Radix Sophorae Flavescentis, Herba Moslae, Flos Lonicerae, Pericarpium Zanthoxyli, the Radix Pulsatillae, Radix Scutellariae carry out fragmentation and be mixed into 100 object mixed materials;
Mixed material after fragmentation and cellulase are carried out enzyme digestion reaction, and the temperature of controlled enzymatic hydrolysis reaction is 48 DEG C, and pH value is 6.5, and enzymolysis time is 80min, and the concentration of enzyme digestion reaction mixed liquor cellulase is 2.8ul/L.Enzymolysis solution and aqueous solution are carried out mixing Ultrasonic Heating lixiviate after enzyme digestion reaction terminates, Ultrasonic Heating lixiviate adds the aqueous solution of 150ml according to every 10g mixed material powder, and the temperature of Ultrasonic Heating lixiviate is 45 DEG C, time 30min.After Ultrasonic Heating lixiviate, centrifugation is carried out to mixed liquor, after centrifugation, carry out filter pressing, carrying out secondary filter after filter pressing, after secondary filter, be condensed into the extracting solution of 1.6g/ml;
Utilize polyvinylidene fluoride microporous filtering film to carry out microfiltration process to extracting solution, reclaim filtrate, then thin up carry out mixing with surfactant and PH regulator, Borneolum Syntheticum to be made into PH be 5.0 semi-finished product conditioning liquids; Wherein extracting solution, water carry out joining getting according to volume ratio 1:8, and in the semi-finished product extracting solution of configuration, content of bornyl alcohol is 6.0g/L, and in semi-finished product extracting solution, the content of surfactant is 75g/L.
Semi-finished product conditioning liquid carried out sterilization treatment, be then placed in an aseptic still, the sterile nitrogen bubble entering 50 ~ 100um from still pucking carries out secondarily purified process, can obtain female nursing solution for external use after removing mixed liquor blibbing layer.
Embodiment 3
Take Fructus Cnidii respectively by weight 1:1.3:1.7:0.7:1.3:1.4:0.4, Radix Sophorae Flavescentis, Herba Moslae, Flos Lonicerae, Pericarpium Zanthoxyli, the Radix Pulsatillae, Radix Scutellariae carry out fragmentation and be mixed into 100 object mixed materials;
Mixed material after fragmentation and cellulase are carried out enzyme digestion reaction, and the temperature of controlled enzymatic hydrolysis reaction is 48 DEG C, and pH value is 6.5, and enzymolysis time is 80min, and the concentration of enzyme digestion reaction mixed liquor cellulase is 2.8ul/L.Enzymolysis solution and aqueous solution are carried out mixing Ultrasonic Heating lixiviate after enzyme digestion reaction terminates, Ultrasonic Heating lixiviate adds the aqueous solution of 100ml according to every 10g mixed material powder, and the temperature of Ultrasonic Heating lixiviate is 45 DEG C, time 30min.After Ultrasonic Heating lixiviate, centrifugation is carried out to mixed liquor, after centrifugation, carry out filter pressing, after filter pressing, carry out secondary filter again, after secondary filter, be condensed into the extracting solution of 1.5g/ml;
Utilize polyvinylidene fluoride microporous filtering film to carry out microfiltration process to extracting solution, reclaim filtrate, then thin up carry out mixing with surfactant and PH regulator, Borneolum Syntheticum to be made into PH be 5.5 semi-finished product conditioning liquids; Wherein extracting solution, water carry out joining getting according to volume ratio 1:8, and in the semi-finished product extracting solution of configuration, content of bornyl alcohol is 5.5g/L, and in semi-finished product extracting solution, the content of surfactant is 80g/L.
Semi-finished product conditioning liquid carried out sterilization treatment, be then placed in an aseptic still, the sterile nitrogen bubble entering 50 ~ 100um from still pucking carries out secondarily purified process, can obtain female nursing solution for external use after removing mixed liquor blibbing layer.
Embodiment 4
Stability analysis is carried out to the female nursing solution for external use produced in embodiment 1 ~ 3:
Under the female nursing solution for external use produced in Example 1 ~ 3 is respectively placed in 40 DEG C of environment, take out, without precipitated and separated phenomenon after leaving standstill 24h;
Under the female nursing solution for external use produced in Example 1 ~ 3 is respectively placed in 3 DEG C of environment, take out, without precipitated and separated phenomenon after leaving standstill 24h;
Antiinflammatory analysis is carried out to the female nursing solution for external use produced in embodiment 1 ~ 3:
Operate according to standard GB/T 15797-2002:
Add staphylococcus aureus bacteriostasis rate after 2min respectively in female nursing solution for external use obtained in embodiment 1,2 and reach 70%; Add white in female nursing solution for external use obtained in embodiment 1,2 respectively to read bacterial strain bacteriostasis rate after 2min and reach 80%;
Add staphylococcus aureus bacteriostasis rate after 2min respectively in female nursing solution for external use obtained in embodiment 3 and reach 72%; Add white in female nursing solution for external use obtained in embodiment 3 respectively to read bacterial strain bacteriostasis rate after 2min and reach 85%.
During the use of this Feminine care solution, itself and warm water dilution are cleaned, take 10 ~ 15ml at every turn, before general sleep every night, use it to nurse.
Therefore by the synergism that above-mentioned raw materials combination of components produces, thus make obtained female nursing solution for external use have good sterilization, antiinflammatory, clean, moisten, the effect of nursing; This conditioning liquid has broad-spectrum antibacterial, parasite killing, inflammation-resisting itch-stopping and clean external genital effect, thus reaches the Multifunctional effect for the treatment of both the principal and secondary aspects of a disease, and the side effect such as non-stimulated, irritated.
More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof
.
Claims (7)
1. a production technology for female nursing solution for external use, specifically comprises the steps:
S1: take Fructus Cnidii by weight 1:1.2 ~ 1.4:1.2 ~ 1.7:0.5 ~ 0.8:1.2 ~ 1.4:1 ~ 1.4:0.2 ~ 0.4 respectively, Radix Sophorae Flavescentis, Herba Moslae, Flos Lonicerae, Pericarpium Zanthoxyli, the Radix Pulsatillae, Radix Scutellariae carry out fragmentation and be mixed into mixed material;
S2: the mixed material after fragmentation and cellulase are carried out enzyme digestion reaction, is undertaken mixing Ultrasonic Heating lixiviate by enzymolysis solution and aqueous solution after enzyme digestion reaction terminates, carries out sedimentation and filtration after Ultrasonic Heating lixiviate to mixed liquor, reclaims extracting solution;
S3 a: purification process is carried out to extracting solution, then thin up carry out mixing with surfactant and PH regulator, Borneolum Syntheticum to be made into PH be 5.0 ~ 5.5 semi-finished product conditioning liquids;
S4: semi-finished product conditioning liquid carried out sterilization treatment, be then placed in an aseptic still, the sterile nitrogen bubble entering 50 ~ 100um from still pucking carries out secondarily purified process, removing mixed liquor blibbing layer.
2. the production technology of female nursing solution for external use as claimed in claim 1, it is characterized in that: in step S3, extracting solution, water carry out joining getting according to volume ratio 1:8, in the semi-finished product extracting solution of configuration, content of bornyl alcohol is 5.5 ~ 6.0g/L, in semi-finished product extracting solution, the content of surfactant is 75 ~ 85g/L, the density of extracting solution is 1.5 ~ 1.6g/ml, and described surfactant is that dodecyldimethylammonium hydroxide inner salt and cocoamidopropyl dimethylamine amine second lactone are formed by weight 1:1 mixing.
3. the production technology of female nursing solution for external use as claimed in claim 1, is characterized in that: the PH regulator in step S3 is that lactic acid and phosphoric acid are formulated.
4. the production technology of female nursing solution for external use as claimed in claim 1, it is characterized in that: in step S2, the temperature of enzyme digestion reaction is 48 DEG C, pH value is 6.5, and enzymolysis time is 80min, and the concentration of enzyme digestion reaction mixed liquor cellulase is 2.5 ~ 2.8ul/L.
5. the production technology of female nursing solution for external use as claimed in claim 1, it is characterized in that: in step S3, a purification process utilizes micro-filtration membrane to filter, micro-filtration membrane used is polyvinylidene fluoride microporous filtering film.
6. the production technology of female nursing solution for external use as claimed in claim 1, it is characterized in that: in step S2, Ultrasonic Heating lixiviate adds the aqueous solution of 100 ~ 150ml according to every 10g mixed material powder, the temperature of Ultrasonic Heating lixiviate is 45 ~ 50 DEG C, time 20 ~ 30min.
7. the production technology of female nursing solution for external use as claimed in claim 2, is characterized in that:
Fructus Cnidii in step S1, Radix Sophorae Flavescentis, Herba Moslae, Flos Lonicerae, Pericarpium Zanthoxyli, the Radix Pulsatillae, Radix Scutellariae take respectively by weight 1:1.2:1.5:0.5:1:0.2 and carry out fragmentation and be mixed into mixed material;
In step S3, in semi-finished product extracting solution, the content of surfactant is 80g/L, and content of bornyl alcohol is 5.5g/L, and the density of extracting solution is 1.5g/ml.
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| CN201410601238.XA CN104306513A (en) | 2014-11-01 | 2014-11-01 | Production technology of female external care solution |
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| CN102462768A (en) * | 2010-11-09 | 2012-05-23 | 福建省医学科学研究院 | Female nursing solution for external use |
| CN103450298A (en) * | 2013-09-17 | 2013-12-18 | 南京通泽农业科技有限公司 | Novel method for extracting baicalin from scutellaria baicalensis |
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- 2014-11-01 CN CN201410601238.XA patent/CN104306513A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1608648A (en) * | 2003-10-20 | 2005-04-27 | 上海海天医药科技开发有限公司 | Antiseptic Chinese medicine composition and its prepn process |
| CN102462768A (en) * | 2010-11-09 | 2012-05-23 | 福建省医学科学研究院 | Female nursing solution for external use |
| CN103450298A (en) * | 2013-09-17 | 2013-12-18 | 南京通泽农业科技有限公司 | Novel method for extracting baicalin from scutellaria baicalensis |
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Application publication date: 20150128 |