CN104256648A - Total-nutrient formula food for thyroid cancer - Google Patents

Total-nutrient formula food for thyroid cancer Download PDF

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Publication number
CN104256648A
CN104256648A CN201410575376.5A CN201410575376A CN104256648A CN 104256648 A CN104256648 A CN 104256648A CN 201410575376 A CN201410575376 A CN 201410575376A CN 104256648 A CN104256648 A CN 104256648A
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vitamin
thyroid cancer
food
medicine
prebiotics
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胡安然
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/155—Vitamins A or D
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
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    • A23V2400/125—Casei
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    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
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Abstract

The invention provides total-nutrient formula food, specific total-nutrient formula food or non-total-nutrient formula food for a patient suffering from thyroid cancer. The food is prepared by smashing and mixing various medicinal and edible traditional Chinese medicinal extract essences extracted by a pre-hydrolysis SBE (Subacute Bacterioendocarditis) technology, various microencapsulated probiotics and oligopeptide, prebiotics, ammonia acid, carbohydrate, various vitamins and minerals which are extracted by biological enzymolysis according to the requirements of the Code of Food for Special Medical Purposes on the basis of combining the physical characteristics of the patient suffering from the thyroid cancer; the total-nutrient formula food can be used as a single nutrition resource for meeting the nutrition demand of the patient suffering from the thyroid cancer and can also achieve the effects of soothing liver, regulating qi, clearing away toxicity, dissipating stasis, promoting blood circulation to remove blood stasis, reinforcing qi, nourishing blood, nourishing yin, clearing away heat, eliminating residual toxicity, removing cancer and gortre and enhancing the immunity.

Description

The full nutritional formulas of thyroid cancer
Technical field
The invention belongs to integration of drinking and medicinal herbs class formula and food technology field, specifically the Traditional Chinese Medicine marrow of " Chinese medicine of integration of drinking and medicinal herbs " is theoretical and " multiple probio " combines, and adds the full nutritional formulas of thyroid cancer, specific full nutritional formulas or the non-fully nutritional formulas made for auxiliary material with small peptide, prebiotics, amino acid, carbohydrate, B B-complex, composite mineral matter.
Background technology
Thyroid cancer (thyroid carcinoma) is modal thyroid malignancy, it is the malignant tumour deriving from Thyroid follicular epithelial cell, overwhelming majority thyroid cancer originates from follicular epithelial cells, papillary carcinoma (60%) can be divided into by histological type, follicular adenocarcinoma (20%), but prognosis is better, follicular adenocarcinoma tumor growth is very fast, belong to moderate pernicious, easy menses running moves, undifferentiated carcinoma prognosis is very poor, mean survival time 3 ~ 6 months, comparatively common clinically with papillary carcinoma in thyroid cancer, the cause of disease of thyroid cancer: (1) radioactive damage, with the thyroid gland of roentgen radiation x experimental mouse, animal generation thyroid cancer can be impelled, experiment proof 131 I can make the metabolism of thyroid cell change, nucleus is out of shape, thyroxinic synthesis greatly reduces, visible radioactive ray cause the abnormal division of thyroid cell on the one hand, cause canceration, thyroid gland is made to destroy and autacoid can not be produced on the other hand, the a large amount of secretion of the thyrotropic hormone (TSH) caused thus also can inspire thyroid cell canceration, clinically, the thyroid generation of a lot of statement of facts is relevant with the effect of radioactive ray, especially notably, there is thyroid cancer in the children You Yi once accepting mediastinum or neck radiotherapy baby children's phase because of thymus gland enlargement or lymph adenoids, this is because the cell proliferation of children and adolescent is vigorous, radioactive ray are a kind of additional stimulus, easily inspire the formation of its tumour, the chance that thyroid cancer occurs after adult accepts neck radiotherapy is then rare, (2) iodine deficiency, take the photograph excessive iodine or iodine deficiency all can make thyroid 26S Proteasome Structure and Function change, thyroid cancer incidence as Goiter Endemic district of Switzerland be 2 ‰ comparatively the Non-epidemic areas such as Berlin exceed 20 times, on the contrary, high iodine diet also easily brings out thyroid cancer, the highest country of iodine number is taken the photograph by Iceland and Japan, comparatively other countries are high for the discovery rate of its thyroid cancer, this may stimulate the factor of thyroid hyperplasia relevant with TSH, experiment proves, long-term TSH stimulates can impel thyroid hyperplasia, form tubercle and canceration, (3) other thyroid gland pathologies, there is thyroid adenocarcinoma clinically, chronic thyroiditis, the report of nodular goiter or some TG generation canceration, but the relation of these thyroid gland pathologies and thyroid cancer is still certainly difficult, for thyroid adenoma, the thyroid adenoma overwhelming majority is follicular, only 2 ~ 5% is papilloma, as thyroid cancer is formed by adenoma transformation, then the overwhelming majority should be follicular, and in fact thyroid cancer is more than half for taking head cancer, the incidence of supposition thyroid adenoma canceration is also very little, (4) inherent cause about 5 ~ 10% medullary carcinoma of thyroid gland has obvious family history, and be often associated with pheochromocytoma etc., infer that the generation of this carcinoid may be relevant with chromosomal inheritance factor,
Thyroid cancer adopts the mode of parenteral nutrition (namely inputting nutritional drugs) to carry out nutritional supplementation to cancer patient clinically more, and long-term parenteral nutrition supplements and easily causes enteron aisle Villus atrophy, and accompanying infection, thus increases the weight of the harm to body; " integration of drinking and medicinal herbs " is to one of contribution of mankind's most worthy among Chinese original medical science; The traditional Chinese medical science is always emphasized " medication not as dietotherapy ", dietotherapy become modern pursue recover one's original simplicity, the optimal selection of health diet; Allow people dispel slight illness in the process enjoying cuisines, avoid and have an injection, take medicine, even pain of surgery.
For food of special nutrients, there are corresponding regulation and Application and Development in the developed country such as the U.S., European Union; And the full nutritional formulas of wholefood clear stipulaties: 2.1.1 in China GB29922-2013 " special medicine purposes formula food general rule " national food safety standard: can be used as the special medicine purposes formula food that single source of nutrition meets target group's nutritional need; 2.1.2 specific full nutritional formulas: can be used as the special medicine purposes formula food that single source of nutrition meets target group's nutritional need under specified disease or medical condition.
Traditional Chinese medical science traditional medicine is thought: " spleen (i.e. digestive system) is the foundation of acquired constitution ", and stomach health is healthy basis, and 99% of human nutrition needs by intestinal absorption, and intestinal bowel disease is also the source of ten thousand diseases; But along with the age is larger, in enteron aisle, profitable strain (probio) ratio reduces gradually; As Bifidobacterium Bifidum accounts for 98% infant period, be down to 10% to during the middle age, within 65 years old, only account for 5% later; People is older, and probio is fewer, and function of intestinal canal also declines thereupon gradually, more and more studies display, normal flora human consumption, immunity and disease-resistant etc. in have many irreplaceable effects; The change of gut flora composition and the generation of various diseases, particularly intestines problem develop closely related, and find from existing clinical research: probio can play regulating intestinal canal flora, controls intestinal inflammatory effect, is that one intervenes control method safely and effectively.
Though direct probiotic oral has certain effect, but due to probio one cannot field planting in enteron aisle, and stop, occupy-place is little, easily run off, withdraw rear harmful bacteria and easily recur, associated patient needs long-term taking, and treatment cycle is long, often uses afterwards that recurrence rate is very high, for shortening the treatment cycle of associated patient, recurrence rate after minimizing drug withdrawal, this team is by studying the key technology of probio field planting mechanism in enteron aisle over nearly 3 year, make great efforts " Chinese medicine of the integration of drinking and medicinal herbs " compound seeking to improve probio field planting in enteron aisle, consider several key elements of probio field planting in enteron aisle: the existence of prebiotics can play field planting effect, the reduction of intestinal pH environment and the enteron aisle adhesive capacity etc. of raising probiotic cell, based on above-mentioned key element, suitable food materials screen from tens of kinds " Chinese medicines of integration of drinking and medicinal herbs " in this seminar, Late Cambrian interpolation Chinese yam, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, the extract of the traditional Chinese medicine ingredients of the integration of drinking and medicinal herbs such as Gorgon fruit and jerusalem artichoke and stachyose, yeast, after Glu etc., very strong field planting effect is had to external source probio, prescription for probio in enteral microecological formulation is selected to provide experimental basis.
Favourable is in the market primary raw material in order to eat source property small peptide, add the mushroom of medicine-food two-purpose, dried orange peel, matrimony vine, Chinese yam, Poria cocos, the extract of sealwort etc., B B-complex and mineral matter composition compound prescription, utilize the product that probio is primary raw material in addition, but also do not find the constitutive character in conjunction with thyroid cancer patients, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility is with the Chinese medical extract elite of multiple medicine-food two-purpose, multiple probio, small peptide is primary raw material, with prebiotics, carbohydrate, amino acid, multivitamin, several mineral materials is the full nutritional formulas that auxiliary material is made, specific full nutritional formulas or similar products.
goal of the invention
The object of the invention is on the theoretical treatment method of succession traditional Chinese medical science marrow, the initiative extract by the probio of multiple raising thyroid cancer patients immunity and " Chinese medicine of integration of drinking and medicinal herbs " compound combines, add with small peptide, amino acid, carbohydrate, multivitamin, several mineral materials is auxiliary material, the thyroid cancer patients institute essential nutrients of hypoimmunity can not only be supplemented, improve body nutrition condition, can also and utilize function factor in medicine-food two-purpose Chinese herbal medicine to regulate body function, probio can play regulating intestinal canal flora, toxic and side effect is little, safe and effective, and the full nutritional formulas that the acceptable applicable thyroid cancer patients of people is edible, specific full nutritional formulas or non-fully nutritional formulas.
summary of the invention:
This R&D team is according to the requirement of " special medicine purposes formula food general rule ", the constitutive character of the thyroid cancer patients that binding immunoassay power is low, the advanced physiology of comprehensive nowadays American Harvard University, medicine, the achievement in research such as nutrition and clinical practice, according to " the middle residence that disappears benefit ", marrow theory (the liver of the Traditional Chinese Medicine of " equilibrium is taken good care of ", spleen, kidney three is dirty with being adjusted to main principle), adopt the Chinese medical extract elite of more than 6 kinds medicine-food two-purposes, multiple probio, small peptide is primary raw material, with prebiotics, carbohydrate, amino acid, multivitamin and mineral matter auxiliary material, not only can be used as the nutritional need that single source of nutrition meets thyroid cancer patients, also has dispersing stagnated hepatoqi, detoxicating and resolving a mass, promoting blood circulation and removing blood stasis, nourishing qi and blood, replenishing the vital essence and removing heat, dispel residual poison, cancer is gone to disappear the full nutritional formulas of effect of goitre and develop immunitypty, specific full nutritional formulas or non-fully nutritional formulas (compound prescription be combined into).
1, the main component of the present invention's formula is:
Chinese medical extract is dirty with being adjusted to main principle from the liver,spleen,kidney three theory of traditional Chinese medical science according to the constitutive character of thyroid cancer patients, utilize the function factor in medicine-food two-purpose Chinese herbal medicine to regulate body function to build up resistance, and choose following several large class medicine and carry out compatibility; Wherein: the stem of noble dendrobium, reinforcing stomach reg fluid is nourishing Yin and clearing heat; Radix Codonopsis, has develop immunitypty, hemangiectasis, step-down, improves microcirculation, strengthens the effects such as hematopoiesis function; The Radix Astragali, invigorating qi for strengthening superficies, diuresis holder poison, apocenosis, expelling pus and promoting granulation; The bighead atractylodes rhizome, has strengthening the spleen and replenishing qi, eliminating dampness Li Shui, hidroschesis, antiabortive effect; Rascal, soothing the liver relieving stagnant Qi; Long-pendingization that disappear is stagnant; Bulbus Fritillariae Cirrhosae, has clearing heat and eliminating phlegm, moistens the lung and relieve the cough, effect of mass dissipating and swelling eliminating; Cordyceps militaris, whole body function can be regulated, improve immunocompetence, strengthen the phagocytic function of macrophage, the formation of enhancing antibody, mainly contain and protect the nourishing the liver of lung kidney-nourishing, relieving cough and asthmaly to eliminate the phlegm, moisturizing wrinkle resistant anti-ageing, antimicrobial antiphlogistic, calmness, hemangiectasis, reduce blood pressure, reduce the effects such as blood sugar, antifatigue, resist oxygen lack.Cordycepin in Cordyceps militaris has effect of the growth of antiviral, antibacterial, obvious Tumor suppression, interference human body RNA and DNA synthesis; Aloe, the thick substances polysaccharide in aloe has the effect improving immunity and suppression, destroy paracytic growth, thus reaches anticancer object; Cordate houttuynia, energy is clearing heat and detoxicating, sore, promoting urination and removing dampness, clearing away heat to cure dysentery, stomach strengthening and digestion promoting are treated in detumescence; Radix et Rhizoma Gynurae divaricatae, heat-clearing, relaxing muscles and tendons, hemostasis, the stasis of blood of dispelling; Chrysanthemum, has the merit of dispelling wind, flat liver; Chinese yam, has nourishing strong, aid digestion, holds back abnormal sweating, effect of antidiarrheal; Poria cocos, is used as medicine and has the function of clearing damp and promoting diuresis, beneficial spleen and stomach, antitoxic heart-soothing and sedative; Matrimony vine, the effects such as LBP-X has Promote immunity, anti-ageing, antitumor, scavenging free radicals, antifatigue, radioresistance, protects the liver, reproductive function protection and improvement; Lily, Yin nourishing and lung moistening; Clearing away the heart fire and tranquillizing;
Medicinal and edible Chinese medicine extract of the present invention refers to Cordyceps sinensis (aweto mycelium), the stem of noble dendrobium, lucidum spore powder (broken wall), glossy ganoderma, Radix Codonopsis, the Radix Astragali, pangolin, the bighead atractylodes rhizome, rascal, Bulbus Fritillariae Cirrhosae, Cordyceps militaris, aloe, cordate houttuynia, Radix et Rhizoma Gynurae divaricatae, chrysanthemum, Chinese yam, Poria cocos, matrimony vine, red date, kelp, coix seed, lily, marine alga, reed rhizome, selfheal, black fungus, white fungus, the root of Dahurain angelica, peach kernel, purslane, honeysuckle, cape jasmine, mulberry fruit, sea-buckthorn, pawpaw wherein more than 6 kinds or all, biological enzymolysis or prehydrolysis SBE is adopted to extract and microencapsulation, mixture after spray-dried and cryodesiccated extract.
2, multiple probio: make probio major part can arrive enteron aisle by the strong acid environment of stomach, to promote the propagation of probio, regulate microecological balance in intestines, promote the absorption to trace element, strengthen taste motor function, accelerate the absorption of drug effect, improve the micropopulation of mucous membrane surface or the balance of enzyme, or stimulate body specificity or nonspecific immunity mechanism, improve body colonization resistance or immunity; Xing etc., with Bifidobacterium and Bacillus acidi lactici pretreatment law during ischemia/reperfusion rat, obviously can reduce the level of intestinal endotoxemia and the generation of preventing liver injury; Selective enteron aisle decontamination dye is also the important measures of adjustment intestinal microecology, has research application enteron aisle not absorb rifamycin antibiotic former times bright (rifaximin), by urease-producing in suppression enteron aisle and the growth of producing ammonium bacteria, builds up resistance;
Multiple probio of the present invention all adopts the probio after microencapsulation, except streptococcus thermophilus, wherein Bifidobacterium: refer to that bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis, bifidobacterium longum are wherein a kind of, several or all mix; Lactobacillus refers to: lactobacillus acidophilus powder, Lactobacillus casei, lactobacillus bulgaricus, Lactobacillus delbrueckii, newborn subspecies lactobacillus gasseri, lactobacillus fermenti, Lactobacillus helveticus, Lactobacillus salivarius, Lactobacillus rhamnosus, lactobacillus reuteri, Lactobacillus plantarum, lactobacillus paraceasi, Yue Shi lactobacillus are wherein a kind of, several or all mix.
3, small peptide: be oligopeptide, refer to the small molecule protein utilizing bio-enzyme engineering technology separation and Extraction from animal or vegetable protein, its mean molecule quantity is at below 1000Dalton, soluble in water, to acid, thermally-stabilised, can not need directly to absorb through digestion, bioavailability is high, absorbing and utilizing the amino acid and complete protein that are better than dissociating, can be applicable in Protein intake food, especially for the crowd that abilities of digestive and absorption is low, small peptide is splendid nitrogenous source, except trophic function, small peptide also has a series of physiological active functions: the digestion and absorption function improving small intestine, strengthen immunity of organisms, anti-oxidant, auxiliary adjustment blood sugar, auxiliary adjustment of blood fat, aided blood pressure-lowering, radioresistance, promote mineral absorption, strengthen the action effect of function factor in medicine-food two-purpose Chinese herbal medicine,
Small peptide of the present invention refers to that maize oligopeptide, wheat oligopeptide, marine collagen peptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide are wherein a kind of, several or all mix.
4, prebiotics: with short probio intestinal colonisation, enteron aisle convergence, reduce intestinal pH environment, also do not utilized by most enteron aisle spoilage organisms, but beneficial bacteria in human body can be promoted---the growth and breeding of lactobacillus, Bifidobacterium, thus spoilage organisms can be suppressed to grow, contribute to improving and maintaining enteron aisle normal function; Long-term edible can to delay senility, defaecation, raising immunity, the absorptivity that alleviates burden of liver, improve nutrient, particularly can improve the absorption of body to metal ions such as calcium, iron, zinc; Optionally promote outside the growth and breeding of beneficial bacterium (bifid, lactic acid), also can metabolism be acid product as organic acids such as lactic acid, knot intestinal pH is reduced, suppresses the growth of intestinal harmful bacillus; Water-Electrolyte in small intestine is made to be trapped in enteric cavity, produce and highly ooze effect, enterocinesia is stimulated to cause laxative, thus promote the discharge of intestinal endotoxin and other toxicants, lactulose also can directly endotoxin in deactivation enteron aisle, reduce gut pH, extensively model is applied to the treatment of enhancing thyroid cancer resistance;
Prebiotics of the present invention is 2 classes
A. very strong field planting effect prebiotics is had to external source probio: the extract of Chinese yam, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, jerusalem artichoke, stachyose, yeast wherein several or all mix;
B. common prebiotics: oligoisomaltose, FOS, soyabean oligosaccharides, xylo-oligosaccharide one wherein, several or all mix;
Originally oligoisomaltose, stachyose, FOS, soyabean oligosaccharides, xylo-oligosaccharide one wherein, several or all mix is referred to.
5, carbohydrate: carbohydrate is by carbon, hydrogen and oxygen three kinds of element compositions, it is for human body provides nutrient the most cheap in three of heat energy kinds of main nutrients, when taking in sufficient, energy can be provided in time by rapid oxidation in vivo, the protein of preciousness is avoided to be used to provide energy, carbohydrate is also the glycoprotein of cell membrane, the glycolipid of nerve fiber and the important composition composition of DNA (DNA) conveyed hereditary information, and the glycogen contained in carbohydrate, when it lays in abundance in liver, liver cell has stronger detoxification ability to the toxin that some poisonous chemical substance and various pathogenic microorganisms produce,
Carbohydrate of the present invention refers to Arabinose, fructose, galactolipin, lactose, glucose, maltose, water-soluble dietary fiber, starch, glycogen one wherein, several or all mix.
6. amino acid: be divided into essential amino acid and nonessential amino acid, is the base unit forming protein, gives protein specific molecular morphosis, make it have biochemical activity; Absorb appropriate methionine and contribute to the metabolism of various sulfur-containing compound in human body and the methyl contained by it methylates to Toxic or medicine and plays the effect of removing toxic substances; Leucine can repair muscle, controls blood sugar, and provides energy to bodily tissue, essential amino acid phenylalanine can suppress cancer growth, can reduce again the toxic and side effect of medicine, and lysine can improve absorption and the utilization of food protein, reach balanced nutritious, enhancing development; Arginine contributes to changing the ammonia in blood into urea and excreting out; For hyperammonemia, hepatic dysfunction etc. are all powerful; Histidine reduces gastric acidity, relaxes the pain of gastrointestinal procedures, alleviates gestational period vomiting and scorching hot sense, suppresses nervous by vegetative nerve and alimentary canal that is that cause festers, to anaphylactia, as also powerful in asthma etc.; Tryptophan can prevent pellagra, depression, improving water flood and adjustment mood;
Amino acid of the present invention refers to Glu, methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine one wherein, several or all mix.
7. vitamin and mineral matter:
Vitamin and mineral matter are the nutrients of needed by human, the nutrient of the vitamin added in the present invention to be vitamin and mineral matter be needed by human;
The vitamin added in the present invention is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, Cobastab e, Cobastab u, nicotinic acid, folic acid, pantothenic acid, choline, biotin one wherein, several or all mix;
The mineral matter added in the present invention is calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum one wherein, several or all mix, and mineral matter of the present invention is added to the organic or inorganic compound of this mineral matter;
In the present invention, the addition of vitamin and minerals performs with reference to " special medicine purposes formula food general rule ", now for 1000g finished product, addition is vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, vitamin K1 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, vitamin B6 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g.
8. the present invention is with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology of the industrialization production of formation; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, the effect making product prevent and treat thyroid cancer significantly improves compared with the like product of market.
9. adopt above-mentioned integrated innovation technique various batching to be mixed solid beverage, the granule of making powdery, and be distributed into 10g/ bag, after dissolving with about 150ml warm water (45 degree), directly drink or take in through nasal feeding; Also can add appropriate attached material make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if make beverage, save spray-dried, add auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations all carries out meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require.
The characteristic of this full nutritional formulas of filling a prescription and the following aspects is mainly manifested in the effect of body:
1. the present invention is the requirement according to " special medicine purposes formula food general rule ", in conjunction with the constitutive character of thyroid cancer patients, the achievement in research developments such as the advanced physiology of comprehensive nowadays American Harvard University, medicine, nutrition and clinical practice, vary with each individual, gold compatibility.
2. the present invention is according to the marrow theory (liver,spleen,kidney three is dirty with being adjusted to main principle) of the Traditional Chinese Medicine of " the middle residence that disappears is mended ", " equilibrium is taken good care of ", the Chinese medical extract elite of multiple medicine-food two-purpose, multiple probio, small peptide is adopted to be primary raw material, with prebiotics, carbohydrate, amino acid, multivitamin and mineral matter for auxiliary material, the organic assembling of various batching, various function is merged, and by the synergy between active ingredient, humidification effect.
3. have effective absorbency, utilize formula of the present invention, various component adopts the food of suitable ratio collocation preparation, in isotonic state after a certain amount of water-soluble solution, small intestine can be arrived quickly through stomach, absorb fast, completely, thyroid cancer patients desired nutritional can be supplemented rapidly.
4. in the present invention's formula, adopt the extract of various medicine-food two-purpose Chinese herbal medicine, containing several functions active component, not only increase the concentration of function factor, reduce the absorption of various impurity, contribute to alleviating liver kidney burden, have and strengthen the effect of resistance of human body, also have dispersing stagnated hepatoqi, detoxicating and resolving a mass, promoting blood circulation and removing blood stasis, nourishing qi and blood, replenishing the vital essence and removing heat, dispel residual poison, go cancer to disappear effect of goitre and develop immunitypty.
5. probio contained in the present invention's formula, multiple probio can safeguard enteron aisle normal bacteria colony balance, suppress the growth of pathogen, prevent gastrointestinal disorders etc., synthetic vitamin in enteron aisle, amino acid and raising body are to the absorption of calcium ion, strengthen human immunologic function, prevent antibiotic side effect, improve host to the tolerance of radioactive ray, lactobacillus significantly increases intestinal mucosal immune globulin A (SIgA) content, to body intestinal mucosa local immunity, there is regulating action, regulate stomach, intestines Tiny ecosystem, calcium can be improved, phosphorus, the utilization rate of iron, promote the absorption of iron and vitamin D, produce vitamin K and Cobastab, the absorption of cholesterol can also be reduced.
6. formula food of the present invention with the food source property bioactive short peptide in multiple source for nitrogenous source, because small peptide does not need digestion and Absorbable rod, more be conducive to the utilization of body, can effectively improve thyroid cancer patients negative nitrogen balance, and food source property small peptide can improve the 26S Proteasome Structure and Function of intestinal epithelial cell, improves the absorbability of intestinal mucosa.
7. this prescription have employed this team by over nearly 3 year to the achievement that the key technology of probio field planting mechanism in enteron aisle is studied, improve " Chinese medicine of integration of drinking and medicinal herbs " compound of probio field planting in enteron aisle, the existence combining prebiotics can play the key elements such as field planting effect, the reduction of intestinal pH environment and the enteron aisle adhesive capacity of raising probiotic cell, and therefore the composition of this food formula greatly strengthen the field planting effect to external source probio.
8. prebiotics contained in the present invention's formula; by promoting the growth and breeding of probio in intestines; suppress the growth of spoilage organisms; form one protective barrier at intestinal mucosal surface simultaneously; the damage of enteron aisle spoilage organisms to intestinal mucosa can be resisted; reduce the absorption of intestinal toxic material; intestines peristalsis can also be promoted; accelerate the discharge of residuals in intestines; constipation can be prevented; and by promoting that the growth and breeding of beneficial bacteria of intestinal tract also can strengthen immunity of organisms, the bioactivators such as small peptide, carbohydrate and active polysaccharide have synergy.
9, in the present invention's formula, contained carbohydrate is for human body provides three of heat energy kinds of main nutrients, energy can be provided in time by rapid oxidation in vivo, the protein of preciousness is avoided to be used to provide energy, carbohydrate is also the glycoprotein of cell membrane, the glycolipid of nerve fiber and the important composition composition of DNA (DNA) conveyed hereditary information, and the glycogen contained in carbohydrate, when it lays in abundance in liver, liver cell has stronger detoxification ability to the toxin that some poisonous chemical substance and various pathogenic microorganisms produce.
10, contained in the present invention's formula amino acid, it is the base unit forming protein, give protein specific molecular morphosis, make it have biochemical activity, contribute to the metabolism of various sulfur-containing compound in human body and the methyl contained by it methylates to Toxic or medicine and plays the effect of removing toxic substances, muscle can be repaired, control blood sugar, and provide energy to bodily tissue, also can improve absorption and the utilization of food protein, reach balanced nutritious, enhancing development.
11, formula food of the present invention is containing multivitamin and mineral matter, can supplement rapidly the micronutrient needed for thyroid cancer patients, small peptide by with the chelating of calcium, iron, zinc etc. after, further increase the absorptivity of mineral matter element.
12, not fatty and cholesterol in the present invention's formula, while supplementary protein, micronutrient, can not increase the absorption of fat, cholesterol, avoid the adverse effect of the high protein diet such as meat, egg.
Detailed description of the invention
Below by following examples, the invention will be further described, and it will contribute to understanding the present invention.
Embodiment one
Realizing the full nutritional formulas of the object of the invention thyroid cancer is constitutive character in conjunction with thyroid cancer patients, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility with the Chinese medical extract elite of more than 6 kinds medicine-food two-purposes, multiple probio, small peptide for primary raw material, the food made for auxiliary material with prebiotics, carbohydrate, amino acid, multivitamin, several mineral materials;
Fill a prescription by following raw materials according and consumption thereof: the extract of medicine-food two-purpose: Cordyceps sinensis (aweto mycelium) 10g, stem of noble dendrobium 10g, lucidum spore powder (broken wall) 10g, glossy ganoderma 10g, Radix Codonopsis 10g, Radix Astragali 10g, pangolin 8g, bighead atractylodes rhizome 8g, rascal 8g, Bulbus Fritillariae Cirrhosae 8g, Cordyceps militaris 8g, aloe 8g, cordate houttuynia 8g, Radix et Rhizoma Gynurae divaricatae 8g, chrysanthemum 6g, Chinese yam 6g, Poria cocos 6g, matrimony vine 6g, red date 6g, kelp 4g, coix seed 4g, lily 4g, marine alga 4g, reed rhizome 4g, selfheal 4g, black fungus 4g, white fungus 2g, root of Dahurain angelica 2g, peach kernel 2g, purslane 2g, honeysuckle 2g, cape jasmine 2g, mulberry fruit 2g, sea-buckthorn 2g, pawpaw 2g,
Bifidobacterium 100g, lactobacillus 100g, streptococcus thermophilus 50g, small peptide 200g, prebiotics 100g, several amino acids 100g, carbohydrate 100g, vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, vitamin K1 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, vitamin B6 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g,
First will to be glossy ganoderma during making, Radix Codonopsis, the Radix Astragali, pangolin, the bighead atractylodes rhizome, rascal, Bulbus Fritillariae Cirrhosae, aloe, cordate houttuynia, Radix et Rhizoma Gynurae divaricatae, chrysanthemum, matrimony vine, red date, kelp, lily, marine alga, reed rhizome, selfheal, black fungus, white fungus, the root of Dahurain angelica, purslane, honeysuckle, cape jasmine, mulberry fruit, sea-buckthorn, pawpaw, the membrane of a chicken's gizzard, Chinese yam, Gorgon fruit adds cycloheptaamylose after soaking, after extracting by prehydrolysis SBE technology, spray-dried and preparation flour, add the small peptide that biological enzymolysis extracts again, prebiotics, amino acid, Cordyceps sinensis (aweto mycelium), the stem of noble dendrobium, lucidum spore powder (broken wall) ,carbohydrate, Cordyceps militaris, multivitamin and mineral matter pulverize together and add peach kernel, Poria cocos, coix seed mixing after carry out pasteurization 1 hour, then the Bifidobacterium after microencapsulation, lactobacillus, streptococcus thermophilus mix solid beverage, the granule of making powdery is added, and be distributed into 10g/ bag, after dissolving by about 150ml warm water (45 degree), directly drink or take in through nasal feeding, also can add appropriate attached material make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if make beverage, save spray-dried, add auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations all carries out meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require.
Embodiment two
The full nutritional formulas of above-mentioned thyroid cancer also comprises following component by weight: the extract of medicine-food two-purpose: Cordyceps militaris 12g, aloe 12g, cordate houttuynia 12g, Radix et Rhizoma Gynurae divaricatae 12g, chrysanthemum 12g, Chinese yam 12g, Poria cocos 10g, matrimony vine 10g, red date 10g, kelp 10g, coix seed 10g, lily 8g, marine alga 8g, reed rhizome 8g, selfheal 8g, black fungus 8g, white fungus 8g, root of Dahurain angelica 6g, peach kernel 6g, purslane 6g, honeysuckle 6g, cape jasmine 4g, mulberry fruit 4g, sea-buckthorn 4g, pawpaw 4g, Bifidobacterium 100g, lactobacillus 100g, streptococcus thermophilus 50g, small peptide 200g, prebiotics 100g, several amino acids 100g, carbohydrate 100g, vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, vitamin K1 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, vitamin B6 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g.
Embodiment three
The full nutritional formulas of above-mentioned thyroid cancer also comprises following component by weight: the extract of medicine-food two-purpose: Cordyceps militaris 12g, aloe 12g, cordate houttuynia 12g, Radix et Rhizoma Gynurae divaricatae 12g, chrysanthemum 12g, Chinese yam 12g, Poria cocos 10g, matrimony vine 10g, red date 10g, kelp 10g, coix seed 10g, lily 8g, marine alga 8g, reed rhizome 8g, selfheal 8g, black fungus 8g, white fungus 8g, root of Dahurain angelica 6g, peach kernel 6g, purslane 6g, honeysuckle 6g, cape jasmine 4g, mulberry fruit 4g, sea-buckthorn 4g, pawpaw 4g, Bifidobacterium 100g, lactobacillus 100g, streptococcus thermophilus 50g, small peptide 200g, carbohydrate 150g, prebiotics 100g, several amino acids 100g.
Embodiment four
The full nutritional formulas of above-mentioned thyroid cancer also comprises following component by weight: small peptide 350g, carbohydrate 300g, several amino acids 100g, Bifidobacterium 50g, lactobacillus 50g, streptococcus thermophilus 25g, prebiotics 100g, B B-complex and mineral matter 25g; Energy contained by every 100 g should be not less than 295 kJ (70 kcal).
The present invention with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology that the industrialization of formation is produced; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, the effect making product improve thyroid cancer patients immunity significantly improves compared with the like product of market.

Claims (10)

1. the full nutritional formulas of thyroid cancer, it is characterized in that the constitutive character in conjunction with thyroid cancer patients, marrow according to Traditional Chinese Medicine is theoretical, vary with each individual, gold compatibility with the Chinese medical extract elite of more than 6 kinds medicine-food two-purposes, multiple probio, small peptide for primary raw material, the food made for auxiliary material with prebiotics, carbohydrate, amino acid, multivitamin, several mineral materials;
Fill a prescription by following raw materials according and consumption thereof: the extract of medicine-food two-purpose: Cordyceps sinensis (aweto mycelium) 10g, stem of noble dendrobium 10g, lucidum spore powder (broken wall) 10g, glossy ganoderma 10g, Radix Codonopsis 10g, Radix Astragali 10g, pangolin 8g, bighead atractylodes rhizome 8g, rascal 8g, Bulbus Fritillariae Cirrhosae 8g, Cordyceps militaris 8g, aloe 8g, cordate houttuynia 8g, Radix et Rhizoma Gynurae divaricatae 8g, chrysanthemum 6g, Chinese yam 6g, Poria cocos 6g, matrimony vine 6g, red date 6g, kelp 4g, coix seed 4g, lily 4g, marine alga 4g, reed rhizome 4g, selfheal 4g, black fungus 4g, white fungus 2g, root of Dahurain angelica 2g, peach kernel 2g, purslane 2g, honeysuckle 2g, cape jasmine 2g, mulberry fruit 2g, sea-buckthorn 2g, pawpaw 2g,
Bifidobacterium 100g, lactobacillus 100g, streptococcus thermophilus 50g, small peptide 200g, prebiotics 100g, several amino acids 100g, carbohydrate 100g, vitamin A 0.01g, vitamin D 0.000015g, vitamin E 0.12g, vitamin K 0.0075g, vitamin K1 0.00001g, vitamin C 10.625g, vitaminB10 .016g, vitamin B2 0.016g, vitamin B6 0.015g, Cobastab 0.0023g, Cobastab e, Cobastab u, nicotinic acid 0.2g, folic acid 0.003g, pantothenic acid 0.051g, choline 2.5g, biotin 0.000057g, calcium 6.2g, phosphorus 4.5g, potassium 10g, sodium 16.17g, magnesium 1.7g, chlorine, iron 0.15g, zinc 6.2g, selenium 0.00012g, copper 0.007g, manganese 0.018g, iodine 0.00001g, fluorine 0.00001g, chromium 0.00001g, molybdenum 0.00001g,
Its preparation method is first will to be glossy ganoderma, Radix Codonopsis, the Radix Astragali, pangolin, the bighead atractylodes rhizome, rascal, Bulbus Fritillariae Cirrhosae, aloe, cordate houttuynia, Radix et Rhizoma Gynurae divaricatae, chrysanthemum, matrimony vine, red date, kelp, lily, marine alga, reed rhizome, selfheal, black fungus, white fungus, the root of Dahurain angelica, purslane, honeysuckle, cape jasmine, mulberry fruit, sea-buckthorn, pawpaw, the membrane of a chicken's gizzard, Chinese yam, Gorgon fruit adds cycloheptaamylose after soaking, after extracting by prehydrolysis SBE technology, spray-dried and preparation flour, add the small peptide that biological enzymolysis extracts again, prebiotics, amino acid, Cordyceps sinensis (aweto mycelium), the stem of noble dendrobium, lucidum spore powder (broken wall) ,carbohydrate, Cordyceps militaris, multivitamin and mineral matter pulverize together and add peach kernel, Poria cocos, coix seed mixing after carry out pasteurization 1 hour, then the various batchings that the Bifidobacterium after adding microencapsulation, lactobacillus, streptococcus thermophilus also add appropriate carbohydrate mixing again mix solid beverage, the granule of making powdery, and be distributed into 10g/ bag, after dissolving by about 150ml warm water (45 degree), directly drink or take in through nasal feeding, also can add appropriate attached material make capsule, tablet or add sweetener and black sesame powder make biscuit etc. fast, instant food is convenient to go out to carry edible, if make beverage, save spray-dried, add auxiliary material etc. less, be distributed into 10-65ml/ bottle, early, middle and late 0.5 hour after meal of every day is drink 1 bottle respectively, and all operations all carries out meeting in the clean dried environment that " special medicine purposes formula food Good Manufacture Practice " require.
2. the full nutritional formulas formula of thyroid cancer according to claim 1, it is characterized in that described medicine-food two-purpose Chinese herbal medicine extract is: Cordyceps sinensis (aweto mycelium), the stem of noble dendrobium, lucidum spore powder (broken wall), glossy ganoderma, Radix Codonopsis, the Radix Astragali, pangolin, the bighead atractylodes rhizome, rascal, Bulbus Fritillariae Cirrhosae, Cordyceps militaris, aloe, cordate houttuynia, Radix et Rhizoma Gynurae divaricatae, chrysanthemum, Chinese yam, Poria cocos, matrimony vine, red date, kelp, coix seed, lily, marine alga, reed rhizome, selfheal, black fungus, white fungus, the root of Dahurain angelica, peach kernel, purslane, honeysuckle, cape jasmine, mulberry fruit, sea-buckthorn, pawpaw wherein more than 6 kinds or all mix.
3. the full nutritional formulas formula of thyroid cancer according to claim 1, is characterised in that and can be prepared into powdery, graininess, capsule shape, tablet shape, beverage based food according to described formula mixing.
4. the full nutritional formulas formula of thyroid cancer according to claim 1, also comprises following component by weight: small peptide 350g, carbohydrate 300g, several amino acids 100g, Bifidobacterium 50g, lactobacillus 50g, streptococcus thermophilus 25g, prebiotics 100g, B B-complex and mineral matter 25g.
5. the full nutritional formulas formula of thyroid cancer according to claim 1, is characterized in that described prebiotics is. have that very strong field planting effect prebiotics is Chinese yam to external source probio, heart of a lotus seed benevolence, the membrane of a chicken's gizzard, Gorgon fruit, the extract of jerusalem artichoke, stachyose, yeast and common prebiotics wherein several or all mix.
6. require the full nutritional formulas formula of the thyroid cancer described in 1, it is characterized in that described amino acid is Glu, methionine, isoleucine, tyrosine, phenylalanine, lysine, arginine, histidine, tryptophan, citrulling, ornithine, taurine one wherein, several or all mix.
7. the full nutritional formulas formula of thyroid cancer according to claim 1, is characterized in that described carbohydrate is Arabinose, fructose, galactolipin, lactose, glucose, maltose, water-soluble dietary fiber, starch, glycogen one wherein, several or all mix.
8. the full nutritional formulas formula of thyroid cancer according to claim 1, is characterized in that with microcapsules, biological enzymolysis, prehydrolysis SBE, spraying dry and freeze drying integrated innovation, the key technology of the industrialization production of formation; Microencapsulation resist technology, to efficiently solve in oral process high temperature and strong acid gastric juice to the deactivation of probio; Adopt three layers of buried microcapsules technology of protein, Chinese medical extract again with extract also microencapsulation process through biological enzymolysis or prehydrolysis SBE technology after mixes, to solve the coexistence problems of " multiple probio " and " Chinese medicine of integration of drinking and medicinal herbs " component, there is certain high temperature resistance and strong acid characteristic, be conducive to probio and stop field planting by oral arrival in enteron aisle by gastric juice smoothly, make product prevent and treat thyroid cancer effect and significantly improve compared with the like product of market.
9. the full nutritional formulas formula of thyroid cancer according to claim 1, is characterized in that described vitamin is vitamin A, vitamin D, vitamin E, vitamin K, vitamin K1, vitamin C, vitamin B1, vitamin B2, vitamin B6, vitamin B12, Cobastab e, Cobastab u, nicotinic acid, folic acid, pantothenic acid, choline, biotin one wherein, several or all mix; Described mineral matter is calcium, phosphorus, potassium, sodium, magnesium, chlorine, iron, zinc, selenium, copper, manganese, iodine, fluorine, chromium, molybdenum one wherein, several or all mix.
10. the full nutritional formulas formula of thyroid cancer according to claim 1, is characterized in that described small peptide is marine collagen peptide, maize oligopeptide, wheat oligopeptide, sea bone peptide, Soyprotein peptide, whey protein peptide, ovalbumin peptide is wherein a kind of, several or all mix.
CN201410575376.5A 2014-10-25 2014-10-25 Total-nutrient formula food for thyroid cancer Pending CN104256648A (en)

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CN110800997A (en) * 2019-11-07 2020-02-18 上海复旦奥医医学科技有限公司 Special clinical nutrition formula for thyroid cancer and preparation method thereof
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CN103637181A (en) * 2013-11-01 2014-03-19 胡安然 Special meal for patients with tumor
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Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11279748B2 (en) 2014-11-11 2022-03-22 Clara Foods Co. Recombinant animal-free food compositions and methods of making them
CN105327205A (en) * 2015-12-02 2016-02-17 青岛市中心医院 Traditional Chinese medicine preparation for treating thyroid cancer
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