CN1039609A - The method of the dynamic synthetic water gelatinous material of UV-light - Google Patents
The method of the dynamic synthetic water gelatinous material of UV-light Download PDFInfo
- Publication number
- CN1039609A CN1039609A CN 88105546 CN88105546A CN1039609A CN 1039609 A CN1039609 A CN 1039609A CN 88105546 CN88105546 CN 88105546 CN 88105546 A CN88105546 A CN 88105546A CN 1039609 A CN1039609 A CN 1039609A
- Authority
- CN
- China
- Prior art keywords
- optimal dose
- mould
- irradiation
- photosensitizers
- minutes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Eyeglasses (AREA)
- Materials For Medical Uses (AREA)
Abstract
The method of the dynamic synthetic water gelatinous material of UV-light relates to the manufacturing technology of novel high polymer material.The present invention need not deleterious thermal initiator, only use a small amount of photosensitizers, and the band temperature is descended the mixed dissolution each component, and carries out ultraviolet light irradiation in dynamic mould.Reformed the manufacturing conditions of complicated harshness, shortened the production cycle greatly, reduced production cost,, can be widely used in making various forms of hydrogel products for the making of hydrogel material provides a cost-effective road.
Description
The method of the dynamic synthetic water gelatinous material of UV-light relates to the manufacturing technology of novel high polymer material.
American documentation literature (US-4620954) has reported that a kind of ultraviolet ray causes the technology of copolymerization hydrogel.Promptly with N-vinyl lactam such as N-vinyl pyrrolidone (N-VP) and hydrophobic acrylic acid's ester, as phenyl methyl ethyl propenoate (PHEMA) is monomer, with methacrylic acid alkene lactone is linking agent, with t-J base superoxide (t-BPO) is thermal initiator, with 2.2-dimethoxy-ethylbenzene benzoylformaldoxime (DMPP) or benzoin methyl ether (BZME) is photosensitizers, after mixing under 5 ℃ the temperature, inject mould and use ultraviolet irradiation 50 minutes, then in process furnace under the nitrogen atmosphere 100 ℃ two hours, then will from mould, be moved in the buffer saline hydration 8 days, can get soft contact lense by the irradiation thing.Except above-mentioned severe condition, in whole process, photosensitive dose of optimum dose of ultraviolet ray will be strictly controlled at 0.3%～0.35%(weight percent).It is insufficient that consumption has lacked gained hydrogel rebound resilience, and consumption is many, can form hydrogel like the stiff leather, but also must add thermal initiator 0.4%～0.6%(weight percent) so that further carry out thermopolymerization, otherwise can not get desired hydrogel.Make a general survey of above process, not only condition is quite harsh, the process complexity, and also the amount of employed photosensitizers and thermal initiator is bigger, all can be bonded to the end group of molecular chain in the polymerization process, and certain toxicity is arranged.The gained material also must aquation reach 8 days in buffer salt solution, otherwise material is muddy grained or vaporific, makes production process draw very longly, and the commercialization of making hydrogel material has been subjected to fatal restriction.
The present invention is intended to provide a kind of making method of hydrogel material, has reformed the manufacturing conditions of complicated harshness, has cancelled deleterious thermal initiator, has shortened the production cycle greatly.
The present invention has used Jia Jibingxisuanβ-Qiang Yizhi (HEMA), N-vinyl pyrrolidone (N-VP), esters of acrylic acid, and to have selected Ethylene glycol dimethacrylate for use be linking agent, without thermal initiator, only use a small amount of photosensitizers, mix above-mentioned each component at normal temperatures, after treating that they dissolve each other, add above-mentioned photosensitizers, the dissolving back is in injecting the mould that rotates below 20 ℃ or injecting the mould of dull and stereotyped translation, in nitrogen atmosphere, open ultra-violet lamp, 30～50cm place irradiation 10～50 minutes on the radiation exposed mould of distance, after cooling, get final product transparent fully hydrogel material.
Jia Jibingxisuanβ-Qiang Yizhi used in the present invention (HEMA) 40%～98%, optimal dose 67.5%; N-vinyl pyrrolidone (NVP) 20%～60%, optimal dose 25%; Esters of acrylic acid (RCH
2C
2OOC
nH
2 π+1, n=1～8) and 0～10%, optimal dose 5%; Ethylene glycol dimethacrylate (EGDMA) 1%～3%, optimal dose 2%; Benzoin methyl ether (or ether or butyl ether) 0.03%～0.3%, optimal dose 0.15%.
Regulate above-mentioned formula rate, gained transparent aquagel material property is: tensile strength 5～15KG/cm
2Unit elongation 50～200%, water ratio (in water after the swelling) 38～70%, can make water content 40%, the ultrathin soft contact lense of center thickness 0.03～0.04mm, with water content 55%, the soft contact lense of the ultrathin high-moisture of center thickness 0.03～0.04mm, and the goods of making aspects such as biomedicine.
What Fig. 1 provided is process flow sheet explanation of the present invention:
1, N-VP 2, PHEMA 3, methacrylic acid lactone 4, photosensitizers 5, thermal initiator 6, batching 7, enrich hydration 12 in mould (static state) 8, ultraviolet light irradiation 9, thermopolymerization 10, post-treatment 11, the buffer saline, soft lens finished product.
What Fig. 2 A and Fig. 2 B drew is the synoptic diagram of the dynamic mould of rotary type of the present invention
1, lid, 2, housing 3, inlet suction port 4, transmission seat board 5, buncher 6, air outlet adapter 7, eyeglass mould 8, lasso 9, bearing housing 10, transmission shaft 11, rolling bearing 12, hole back-up ring 13, gear.
Here provide five embodiment of the present invention:
Embodiment 1:HEMA160.6%, Isooctyl methacrylate (EHMA) 38.4%, NVP229.9%, EDGMA41%, Benzoin ethyl ether 50.1%, mixed dissolution 6 evenly after, inject and rotate mould 7, in nitrogen atmosphere, open ultraviolet lamp, 35cm place irradiation is 830 minutes on the distance mixture, after cooling, take out to be placed in 100 ℃ of constant temperature ovens and solidified 2 hours, can make the soft contact lense 10 of high-moisture 70%.
Embodiment 2:HEMA179%, EHMA35%, NVP214.85%, EGDMA41%, Benzoin ethyl ether 50.15% is pressed the technology of example 1 and is made, and can get water content 40%, the ultrathin soft contact lense 10 of center thickness 0.04mm.
Embodiment 3:HEMA165.5%, EHMA38.0%, NVP224.85%, EGDMA41.5%, Benzoin ethyl ether 50.15% is pressed example 1 technology and is made, and can get high-moisture 58%, the ultrathin soft contact lense 10 of center thickness amount 0.04mm.
Embodiment 4:HEMA195%, HEMA32.85%, EGDMA42%, Benzoin ethyl ether 50.15% is pressed example 1 technology and is made, and can get water content 38%, the ultrathin soft contact lense 10 of center thickness 0.04mm.
Embodiment 5:HEMA140%, NVP250%, EHMA38.8%.EGDMA41%, st-yrax 50.2%, mix 6 after, coat on the special gauze on the dull and stereotyped parallel-moving type mould, dull and stereotyped translation mould is with the ultraviolet lamp of speed by opening of 20 centimetres of per minutes, can make permeable, inhale dense blood, gas-pervious hydrogel gauze.
Claims (9)
1, the method for the dynamic synthetic water gelatinous material of UV-light, the manufacturing technology that relates to novel high polymer material, need through preparing burden 6, enrich and rotate mould 7, ultraviolet light irradiation 8, technologies such as post-treatment 9 is characterized in that: Jia Jibingxisuanβ-Qiang Yizhi/and, N-vinyl pyrrole ketone 2, esters of acrylic acid 3, linking agent Ethylene glycol dimethacrylate 4 and photosensitizers 5, at room temperature mixed dissolution 6, evenly dynamic mould 7 is injected in the back, in nitrogen atmosphere, open ultraviolet lamp, the 8 corresponding times of corresponding position irradiation on the distance mixture, carry out post-treatment after cooling and handle 9.
2, method according to claim 1 is characterized in that: Jia Jibingxisuanβ-Qiang Yizhi/(HEMA) 40%～98%, optimal dose 67.5%; N-vinyl pyrrolidone 2(NVP) 20%～60%, optimal dose 25%, esters of acrylic acid 3(RCH
2C
2OOC
nH
2n+1, n=1～8) and 0～10%, optimal dose 5%; Linking agent Ethylene glycol dimethacrylate 4(EGDMA) 1%～3%, optimal dose 2%, benzoin methyl ether 50.03%～0.3%, optimal dose 0.15%.
3, method according to claim 1 is characterized in that: photosensitizers 5 can be used Benzoin ethyl ether 0.03%～0.3%, optimal dose 0.15%.
4, method according to claim 1 is characterized in that: photosensitizers 5 can be used benzoin isobutyl ether 0.03%～0.3%, optimal dose 0.15%.
5, method according to claim 1 is characterized in that: dynamically mould can be centrifugal rotation.
6, method according to claim 1 is characterized in that: dynamically mould can be translation.
7, method according to claim 1 is characterized in that: each component dissolved envrionment temperature is 5 ℃～30 ℃, is suitably for 20 ℃ most.
8, method according to claim 1 is characterized in that: distance is suitably for 35cm most by irradiation thing 30cm～50cm during ultra-violet lamp irradiation 8.
9, method according to claim 1 is characterized in that: 8 times of ultra-violet lamp irradiation are 10 minutes～50 minutes, are suitably for 20 minutes most.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88105546 CN1039609A (en) | 1988-07-15 | 1988-07-15 | The method of the dynamic synthetic water gelatinous material of UV-light |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 88105546 CN1039609A (en) | 1988-07-15 | 1988-07-15 | The method of the dynamic synthetic water gelatinous material of UV-light |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1039609A true CN1039609A (en) | 1990-02-14 |
Family
ID=4833726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 88105546 Pending CN1039609A (en) | 1988-07-15 | 1988-07-15 | The method of the dynamic synthetic water gelatinous material of UV-light |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1039609A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101087860B (en) * | 2004-12-03 | 2010-12-01 | 3M创新有限公司 | Process for making pressure sensitive adhesive hydrogels |
| WO2012129968A1 (en) * | 2011-03-30 | 2012-10-04 | 上海吉岳化工科技有限公司 | Gel pad and method for producing same by ultraviolet light curing |
-
1988
- 1988-07-15 CN CN 88105546 patent/CN1039609A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101087860B (en) * | 2004-12-03 | 2010-12-01 | 3M创新有限公司 | Process for making pressure sensitive adhesive hydrogels |
| WO2012129968A1 (en) * | 2011-03-30 | 2012-10-04 | 上海吉岳化工科技有限公司 | Gel pad and method for producing same by ultraviolet light curing |
| CN102715751A (en) * | 2011-03-30 | 2012-10-10 | 朱雪兵 | Gel pad and UV-curving production method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2035986C (en) | Biologically compatible collagenous reaction product and articles useful as medical implants produced therefrom | |
| US4136250A (en) | Polysiloxane hydrogels | |
| CN101490099B (en) | Actinically crosslinkable copolymers for manufacturing contact lenses | |
| ATE85628T1 (en) | PROCESS FOR MANUFACTURE OF HYDROGEL MOLDINGS, INCLUDING CONTACT LENSES. | |
| CN110078947A (en) | A kind of preparation method of composite gel microsphere, composite gel microsphere and its application | |
| CN101903807A (en) | Method for making contact lenses | |
| CN111533940A (en) | Tannic acid functionalized photo-crosslinked hydrogel stent and preparation method thereof | |
| TW200813518A (en) | Package mold combination | |
| US5260001A (en) | Spincasting process for producing a series of contact lenses having desired shapes | |
| CN111363168A (en) | Mixed gel with anticoagulation effect, preparation method and application thereof | |
| CN106795267A (en) | For the polyurethane of contact lenses | |
| Lai | Influence of solvent composition on the performance of carbodiimide cross-linked gelatin carriers for retinal sheet delivery | |
| Moghaddam et al. | Molecular design of three‐dimensional artificial extracellular matrix: Photosensitive polymers containing cell adhesive peptide | |
| JPS5889271A (en) | Molded product suitable for being used in biomedical use and production thereof | |
| US4153349A (en) | Soft contact lens with thin edge | |
| CN1039609A (en) | The method of the dynamic synthetic water gelatinous material of UV-light | |
| CN101896837B (en) | Method for making silicone hydrogel contact lenses | |
| CN1914028A (en) | Method for producing tinted contact lenses | |
| Sedek et al. | Photocrosslinkable gelatin-treated dentin matrix hydrogel as a novel pulp capping agent for dentin regeneration: I. synthesis, characterizations and grafting optimization | |
| CN1269889A (en) | Process for mfg. of moulding | |
| CN109111555A (en) | A kind of preparation method of high-performance bio compatibility radical photopolymerization visible light initiation system | |
| Zhang et al. | Modification of Silicone Hydrogel Contact Lenses with Vitamin E for the Delivery of Ofloxacin | |
| CN111253590B (en) | Epoxy hydrogel based on amine-epoxy reaction and preparation method and application thereof | |
| CN106236324B (en) | Improve the corneal graft Cascading Methods of tissue engineering artificial corneal diopter | |
| CN114762740B (en) | Adhesive sodium hyaluronate gel for injection and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination |