CN1039571C - Calcium L-threonate for food additives and preparing process and use thereof - Google Patents
Calcium L-threonate for food additives and preparing process and use thereof Download PDFInfo
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- CN1039571C CN1039571C CN96106507A CN96106507A CN1039571C CN 1039571 C CN1039571 C CN 1039571C CN 96106507 A CN96106507 A CN 96106507A CN 96106507 A CN96106507 A CN 96106507A CN 1039571 C CN1039571 C CN 1039571C
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Abstract
The present invention relates to a food additive, a preparation method thereof and the application thereof. The food additive is calcium L-threonate, is capable of obviously improving the taste of food, is easy to absorb by human bodies, rapidly and obviously increases the calcium storage capacity of the human bodies, and achieves the purpose of rapidly supplementing the calcium content of the human bodies. The preparation method has the advantages of reasonable process and easy implement, and the food additive can be used for beverage additives, solid food additives and various seasoning additives.
Description
The present invention relates to a kind of purposes of l threonic acid.
Quickening along with development and national economy and people's lives rhythm, the beverage that makes things convenient for miscellaneous emerges in an endless stream, do not considering whether these beverages meet under the prerequisite of sanitary standard, it is found that, various fruit-flavored beverages, composite beverage and the carbonic acid vapour beverage etc. of market sale now, ubiquity mouthfeel and is sent out puckery, compares the impure topic that is equal to of sweet taste with new fruit drink.On the other hand, people know, calcium is one of most important element in the human body, it participates in all vital movement processes, especially the ionized calcium in the blood plasma is being brought into play prior physiological action, it is necessary to the function of keeping neuromuscular, skeletal system and the permeability of cell membrane and blood capillary, and the condensing of the activation of many enzymes, blood, renal function and keeping of respiratory function all be unable to do without it, and it is also in the release of neurotransmitter and hormone, amino acid whose picked-up with in conjunction with, B simultaneously
12Physiological process such as absorption in also bringing into play important effect.But, according to investigation in recent years, the actual intake of China resident calcium is well below normal person's calcium demand: national average calcium intake only is that 500mg/ is about day, and normal person's calcium demand should be 800～1200mg/ day, both differ very big, so chronically, seriously calcium deficiency will inevitably cause multiple diseases such as osteoporosis.And at present, China still do not have a kind ofly to make absorption of human body and conversion ratio height, to the food additive with calcium supplementing effect of shortcomings such as intestinal has no stimulation.
The purposes that the purpose of this invention is to provide a kind of l threonic acid.
L threonic acid is white particle, and is almost tasteless, can be water-soluble, be insoluble to alcohol, and ether and chloroform, its molecular formula is C
8H
14O
10Ca, chemical structural formula is:
Its preparation method is: add a certain amount of L-ascorbic acid (V in water
C), after the L-ascorbic acid is dissolved fully, slowly add calcium carbonate under stirring, under 10～60 ℃, in above-mentioned system, slowly drip hydrogen peroxide, after in 40～80 ℃, being incubated 1～4 hour, add activated carbon again, filter, filtrate concentrates down at 30～90 ℃, crystallization at room temperature, dry down at 50～100 ℃.
In the preparation method of described l threonic acid, the adding of calcium carbonate is wanted slowly, in order to avoid produce a large amount of carbon dioxides suddenly, is being with in the system liquid to go out outside the container.
Can also comprise in the preparation method of l threonic acid that with adding the filter cake of activated carbon after-filtration with 80 ℃ of hot water wash twice, the merging of washing liquid and filtrate concentrate.
The preparation method technology of l threonic acid is reasonable, simple, and productive rate reaches as high as 90%, and the purity height, is that collection is replenished the calcium and seasoning is the food additive of one.
L threonic acid be the L-ascorbic acid at the intravital metabolite of people, participated in a lot of physiological process, nontoxic, have no side effect, and help human body, and can replenish human calcium's content rapidly ascorbic absorption.
Be to utilize of the experiment of SD rat below to the situation that absorbs and the serum calcium situation of change of l threonic acid.
The SD male rat is used in experiment, conforms after buying and observes 3, is divided into three groups then at random, two experimental grouies (branch high and low dose), a blank group.The weight of animals 203.75 ± 8.76 grams.
Grouping back animal monoculture was at first fed the artificial calcic feedstuff of preparing 3 days in metabolic cage, make it adapt to feedstuff and change.Begin then to change and feed the calcium deficiency feedstuff, to the 4th day on the calcium deficiency feedstuff basis of continuing to feed, press high dose 80mgC
a 2+/ 1 day and low dosage 40mgC
a 2+/ only 1 day, irritate for respectively two experimental group animals to be fed with 3% starch solution of l threonic acid, once a day, the blank group is irritated the starch suspension of stomach 3%.Each treated animal is freely drunk deionized water.
The Nutrition and Metabolism cage can be urinated Mus, excrement separates fully, and regularly collect whole urine, excrement, numbering every day, is used for quantitative assay.
Animal feeding environment: 20 ℃ ± 1 ℃ of room temperature, humidity 55%, Artificial Control light application time 12hr/ days.
The calcium deficiency feed formula is as follows:
% egg albumen powder 24 starch 40 sucrose 23 soybean oils 5 celluloses 4 mixed inorganics 3 mixed vitamins 1
During detection, each animal blood, urine, excrement and feedstuff before and after the experiment are carried out calcium content measure.Blood, urine are directly measured, and the ashing after drying of excrement, feedstuff is measured then.All adopt useful titrimetry and measure, each sample is made three parallel samples, gets average, and the result is as follows:
Table 1 SD rat absorbs situation (%) to l threonic acid
| Dosage | The SD number of rats | Absorbance | Utilization rate | Net utilization |
| 626mg/ day | 10 | 95.30 | 76.83 | 73.22 |
| 313mg/ day | 10 | 89.33 | 89.13 | 79.62 |
Table 2 is compared blood calcium situation of change mg/dl with the blank group
| Dosage | The SD number of rats | The blood calcium value added |
| 626mg/ day | 2.685 | |
| 313mg/ day | 1.480 |
More than two groups of tests, animal calcium net utilization all reaches more than 70%, illustrates that l threonic acid is a kind of calsium supplement with high-absorbility, high usage.
Be the experimental result behind the edible l threonic acid of human body below.
Select 10 of young man volunteers, 22 years old mean age, do not have the absorption of other calcium preparation and high calcium food during being tried.The oral for each person every day l threonic acid of experimenter 1 time, each 1.72 grams, calcic 220mg took 7 days continuously, respectively at before the experiment and after the experiment, left and took 4 hours urine on an empty stomach early morning, urinated calcium and measured.Under the similarity condition, the oral of Citric acid calcium, calcium gluconate and calcium carbonate and detection have been carried out.The mensuration of urine calcium is used the EDTA titrimetry, and the mensuration of urine creatine is used the picric acid colorimetry.
Three index determining results in experiment front and back such as table 3.
Table 3
| 4 hours urine calcium total amounts (mg) | Ca mg/100ml urine | Ca mg/g creatinine | ||||
| Before the experiment | After the experiment | Before the experiment | After the experiment | Before the experiment | Experiment | |
| Meansigma methods standard deviation number confidence factor probability | 27.09 73.03 10.81 22.72 10 10 5.7739 ＜0.01 | 20.64 36.41 4.20 6.68 10 10 6.3200 ＜0.01 | 144.15 266.62 53.67 109.05 10 10 3.1864 ＜0.01 | |||
Above experimental result credit is by statistics analysed processing, and difference all has highly significant between three each data of index experiment front and back, and the P value illustrates that all less than 0.01 l threonic acid can make human calcium's accretion of stock rapidly, reaches the purpose of replenishing human calcium's content rapidly.
Before and after the experiment, several calcium preparation are taken urine calcium amount after 0～4 hour to such as table 2.
Table 4
| The L-threonic acid calcium | Citric acid calcium | Calcium gluconate | Calcium carbonate | |
| 0-4 hour urine calcium amount (mg/dl urine) after taking medicine | 36.41 | 19 | 14 | |
| 0-4 hour urine calcium increment (mg/dl urine) after taking medicine | 15.8 | 9.8 | 6.9 | |
| 0-4 hour urine calcium amount (mg/mg creatinine) after taking medicine | 0.27 | 0.15 | 0.13 | |
| 0-4 hour urine calcium increment (mg/mg creatinine) after taking medicine | 0.123 | 0.081 | 0.045 |
Above experimental result explanation, every result of l threonic acid all is better than Citric acid calcium, calcium gluconate, calcium carbonate, is more suitable for absorption by human body.
Because the optical activity of the l threonic acid as food additive of the present invention causes its biological activity, it is absorbed in vivo easily, can when replenishing the calcium, play the effect that improves food taste.Be that l threonic acid can under the prerequisite of the mouthfeel of improving food, not only increase the nutrition of food as additive of flavourings such as solid food additive, monosodium glutamate such as beverage additive, bread or cookiess, also can play the effect of replenishing the calcium rapidly.
L threonic acid can improve the mouthfeel of all kinds of fruit drinks, composite beverage and carbonic acid vapour beverage as beverage additive, remove astringent taste, promote the fragrant and sweet abnormal smells from the patient of beverage, its main cause is that l threonic acid has the composition (as pigment, tannic acid etc.) of astringent taste to combine with these to have formed tasteless complex.Addition is preferably 0.0.1～1%.
Product below by 10 volunteers that participate in this experiment are repaid contrast, and the characteristic of improving beverage mouthfeel that this beverage additive has is described.
Choose the 125ml almond bevertage, to wherein adding the 50mgL-threonic acid calcium, after 5 minutes, repay with the almond bevertage contrast product that do not add l threonic acid, 10 volunteers think that all mouthfeel obviously improves, and do not have puckery nonirritant, pure fragrant and sweet flavor increase.
Other gets 125ml orange granule juice beverage, to wherein adding the 50mgL-threonic acid calcium, makes the contrast product with blank after 5 minutes and repays, and 10 volunteers think that all mouthfeel obviously improves, and do not have puckery nonirritant, and are pure fragrant and sweet good to eat, approach the pure juice taste.
Get the Shanhai Pass Orange soda (carbonic acid vapour type) of 125ml again, to wherein adding the 50mgL-threonic acid calcium, make the contrast product with blank after 5 minutes and repay, 10 volunteers think that all mouthfeel obviously improves, and are no puckery, pure fragrant and sweet good to eat, near the pure juice mouthfeel.
Choose sprite, Finda each 200mL of carbonic acid vapour beverage of being produced by Coca-Cola again, to wherein adding the 50mgL-threonic acid calcium, make contrast product with blank after 5 minutes and repay, 10 volunteers think that all mouthfeel obviously improves no puckery and sweet taste increase.
L threonic acid can increase the sweet taste of food as solid food additives such as bread, cookiess, increases the nutrition of food, more importantly is to reach the purpose of replenishing the calcium, and addition is preferably 1～5%.
The present invention is described further below in conjunction with embodiment.
Embodiment
In the reactor that agitator and cooling water sandwich are installed.The L-ascorbic acid that adds 25Kg water and 17.6Kg, after the L-ascorbic acid is fully dissolved, stir and slowly add the 20Kg calcium carbonate down, remain at system temperature under 30～40 ℃ the situation, slowly drip the 40Kg hydrogen peroxide, and keep 30～40 ℃ of constant temperature, add activated carbon then, be warmed up to and be concentrated to 1/3 of original volume under 60 ℃, cooling, crystallization, the dry finished product l threonic acid that gets.
The l threonic acid that makes as beverage additive, is added in the orange juice (every bottle contains l threonic acid 1.6g).Child's (7 years old age) by 10 serious calcium deficiency drinks three bottles every day, drinks continuously 15 days, and 10 children declare with one accord, the orange juice that has added additive is drunk than getting well of not adding, and does not have astringent taste, and mouthfeel is fragrant and sweet, and 10 children's calcium deficiency phenomenon is clearly better, and cure rate reaches 90%, and concrete testing result is as follows:
4 effective percentage 40% of responder in 3 days
7 effective percentage 70% of responder in 4 days
10 effective percentage 100% of responder in 10 days
8 cure rates 80% of healing person in 10 days
9 cure rates 90% of healing person in 15 days
With the l threonic acid that makes additive as bread, select child's (8 years old age) of 10 serious calcium deficiency, eat two gems (including l threonic acid 4g) every day, eat 10 days continuously after, testing result is as follows:
Responder's 7 people's effective percentage 70% in 5 days
Responder's 10 people's effective percentage 100% in 10 days
Healing person's 8 people's cure rates 80% in 15 days
Above presentation of results, employing l threonic acid of the present invention can improve the mouthfeel and the grade of food significantly as the additive of varieties of food items, more adapt to absorption by human body, particularly after having eaten the food that contains l threonic acid, can increase the calcium reserves of human body promptly, significantly, reach the purpose of replenishing human calcium's content rapidly.
Claims (4)
1, the purposes of l threonic acid in the preparation calsium supplement.
2, purposes as claimed in claim 1, wherein this calsium supplement is the solid food additive.
3, purposes as claimed in claim 1, wherein this calsium supplement is a beverage additive.
4, purposes as claimed in claim 1, wherein this calsium supplement is an additive of flavourings.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96106507A CN1039571C (en) | 1996-06-13 | 1996-06-13 | Calcium L-threonate for food additives and preparing process and use thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96106507A CN1039571C (en) | 1996-06-13 | 1996-06-13 | Calcium L-threonate for food additives and preparing process and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1143464A CN1143464A (en) | 1997-02-26 |
| CN1039571C true CN1039571C (en) | 1998-08-26 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96106507A Expired - Fee Related CN1039571C (en) | 1996-06-13 | 1996-06-13 | Calcium L-threonate for food additives and preparing process and use thereof |
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1074762C (en) * | 1998-08-18 | 2001-11-14 | 北京巨能亚太生命科学研究中心 | Process for preparing chromium L-threonate, its preparing process and application |
| CN1196480C (en) * | 2001-07-03 | 2005-04-13 | 北京巨能亚太生命科学研究中心 | Application of calcium L-threonate for curing fracture |
| CN1197561C (en) * | 2001-07-03 | 2005-04-20 | 北京巨能亚太生命科学研究中心 | Application of calcium L-threonate in treating cartilage related diseases |
| US8178118B2 (en) | 2007-03-22 | 2012-05-15 | Magceutics, Inc. | Magnesium compositions and uses thereof for cognitive function |
| CN102573496B (en) | 2009-07-01 | 2015-08-26 | 玛格塞蒂克斯公司 | Slow release magnesium composition and uses thereof |
| CN112047836A (en) * | 2020-09-16 | 2020-12-08 | 浙江天瑞化学有限公司 | Preparation method and equipment of calcium L-threonate |
| CN112724032A (en) * | 2020-12-28 | 2021-04-30 | 宁波盈前科技有限公司 | Threonine calcium product and production method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4822816A (en) * | 1987-04-10 | 1989-04-18 | Oxycal Laboratories, Inc. | Compositions and methods for administering vitamin C |
| WO1990012571A1 (en) * | 1989-04-07 | 1990-11-01 | Oxycal Laboratories, Inc. | Compositions and methods for administering vitamin c |
-
1996
- 1996-06-13 CN CN96106507A patent/CN1039571C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4822816A (en) * | 1987-04-10 | 1989-04-18 | Oxycal Laboratories, Inc. | Compositions and methods for administering vitamin C |
| WO1990012571A1 (en) * | 1989-04-07 | 1990-11-01 | Oxycal Laboratories, Inc. | Compositions and methods for administering vitamin c |
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| CN1143464A (en) | 1997-02-26 |
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