CN103907599A - Application of N,N-dimethyl hydrogenated nopyl amide as insect repellant - Google Patents
Application of N,N-dimethyl hydrogenated nopyl amide as insect repellant Download PDFInfo
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Abstract
The invention relates to an application of N,N-dimethyl hydrogenated nopyl amide as an insect repellant, which comprises an application of N,N-dimethyl hydrogenated nopyl amide as ant and cockroach repellants. The biological measurement result displays that N,N-dimethyl hydrogenated nopyl amide with 50mg/g concentration has 72% of repellent rate to monomorium pharaonis, and N,N-dimethyl hydrogenated nopyl amide with 100mg/g concentration has 100% of repellent rate to monomorium pharaonis; in on-site tests, N,N-dimethyl hydrogenated nopyl amide has good effect; and the N,N-dimethyl hydrogenated nopyl amide with 100mg/g concentration has 69% of repellent rate to cockroach.
Description
Technical field
The present invention relates to a kind of N, the application of acid amides as insect repellent foretold in N-dimethyl hydrogenation promise, belongs to field of pest control.
Background technology
The method that current people prevent and treat vector insect mainly contains two kinds: the one, and use of insecticide, the 2nd, use repellant, repellant can be avoided these deficiencies preferably.But the long-term use of insecticide is easily developed immunity to drugs, and toxicity is large, environmental pollution is serious.Repellant application aspect control sanitary insect pest is comparatively general, and concerning often in the wild movable people, use repellant is important preventive means.In the research of repellant, the terpenoid of plant resource has caused people's concern with its hypotoxicity, bland feature.
At the beginning of the fifties, the McCabe of the U.S. has synthesized Metadelphene (DEET, i.e. DEET), and for the control of hematophagus.DEET was once internationally recognized wide spectrum, efficient, safe desirable repellant, and service time is long, range of application is also the widest.But find successively in recent years its some shortcomings, after long-term use or a large amount of use, there will be neurological symptom, skin injury, the cardiovascular problem such as poisoning, and some allergic symptoms in old man and children, are also there are, also to some insect, as the non-constant of effect of important Malaria Vectors light color anopheles.Along with the raising of people's environmental consciousness and the reinforcement to self health concerns consciousness, plant resource terpenoid repellents will be played the part of more key player in pest control.
In recent decades, Chinese scholars has been done a large amount of research work to terpene repellent activity material, has extracted many activated compositions from a large amount of plants.Can be divided into two class materials by preventing and treating function, mosquito be had to the secondary compound of volatile plant and the non-volatile Plant Secondary Materials compound that is considered to inhibitor of repellent action.From chemical composition, mostly be monoterpene, sequiterpene, alkene, ester, alcohol, ketone compounds etc., also there are many other compositions, as alkaloid, flavonoids etc.Wang Zongde etc. have synthesized 32 terpenoids take turpentine oil as raw material, and the repellent activity of these compounds is studied, and have filtered out some and have the compound of better repellent activity.
Terpenoid repellents more and more becomes indispensable important component part in repellant.The repellent effect of many terpenoid repellents is better, and mostly has aromaticity with it, derives from natural terpene, and toxicity is low, excitant is little, to human body and environmentally friendly, and is accepted extensively by people.Therefore, terpenoid repellents more and more causes people's research and development interest.In recent years, directly utilize the example of the plants essential oil that is rich in terpenoid repellents a lot, also had the Successful Practice of artificial synthetic terpenoid repellents.But from current terpenoid repellents overall development, relevant research mainly biases toward the exploitation of preparation, the research report of the synthetic terpenoid new varieties with repellent effect is still few, therefore be, a direction that is worth further investigation and exploitation by the synthesizing hydrogenated nopol of nopinene and derivative thereof.
Summary of the invention
For solving the problems of the technologies described above, the invention provides a kind of terpenoid N, the application of acid amides as insect repellent foretold in N-dimethyl hydrogenation promise.
The said compound of the present invention is N, and acid amides is foretold in N-dimethyl hydrogenation promise, and its basic parameter is as shown in table 1.
Table 1N, the basic parameter of acid amides is foretold in N-dimethyl hydrogenation promise
The present invention, through experiment sieving, finds N, and N-dimethyl hydrogenation promise is foretold acid amides some insect is had to obvious repellent activity, comprising ant and cockroach.Ant is the caste the most common on the earth, quantity is maximum, the dangerous act of ant comprises stinging disturbs human body, spreads disease germs, damages building, contaminated environment etc., after being bitten by it, often cause papule erythema and pruitus, particularly baby's body exudates has attracting action to ant, more subject to invasion and attack, when serious, can cause damage to health.Cockroach is also a kind of medium insect, and it spreads disease, unhealthful.The main chemical control method that relies at present, but a large amount of uses of chemical insecticide have caused, Insecta is drug-fast to be developed rapidly.
The present invention finds N, and the repellent activity that acid amides is foretold in N-dimethyl hydrogenation promise comprises: N, and the application of acid amides as ant repellant foretold in N-dimethyl hydrogenation promise, N, the application of acid amides as cockroach repellant foretold in N-dimethyl hydrogenation promise.
Bioassay results shows, the N of 50mg/g concentration, and N-dimethyl hydrogenation promise fore-telling acid amides has reached 72%, 100mg/g concentration to the scattering ratio of monomorium pharaonis the scattering ratio of monomorium pharaonis has been reached to 100%.In testing at the scene, N, N-dimethyl hydrogenation promise is foretold acid amides and has also been shown good effect.N, it is 69% to the scattering ratio of cockroach that acid amides is foretold in N-dimethyl hydrogenation promise in the time that concentration is 100mg/g.
N; the repellent activity that acid amides is foretold in N-dimethyl hydrogenation promise has great importance for the harm of control ant and cockroach; Code in Hazardous Special Locations that particularly can not use of insecticide to some; utilize repellant both can realize the object of protection, can avoid again the accidental poisoning and the irritated accident that cause because of use of insecticide.
Embodiment
Below in conjunction with embodiment, the specific embodiment of the present invention is described in further detail.Following examples are used for illustrating the present invention, but are not used for limiting the scope of the invention.
Embodiment 1N, the test of acid amides to ant repellent effect foretold in N-dimethyl hydrogenation promise
By N, N-dimethyl hydrogenation promise fore-telling acid amides is diluted to series concentration with absolute ethyl alcohol and does active testing use, and test method adopts buckwheat seed immersion method.
Select that Individual Size equates, 12 of identical buckwheat seeds of shape, in the ethanol solution that wherein 6 immerse tested materials, other 6 immersions are containing in the absolute ethyl alcohol of tested material.
After seed taking-up is dried, be placed on respectively both sides symmetrical in the culture dish that diameter is 9cm, 6 seeds are lined up two row, 3 of every row, the about 0.5cm of line-spacing, the about 0.1cm of distance between buckwheat seed.20 monomorium pharaonis worker ants are put into culture dish central authorities, after 2min, start to observe, record monomorium pharaonis number of times through contrast or tested buckwheat seed in 2min.Test is controlled at 26 ± 1 ℃ in temperature, and carry out in the laboratory of relative moisture 65+5%.
Calculate monomorium pharaonis and be scattering ratio (%) through the difference of contrast buckwheat seed number of times and tested buckwheat seed number of times divided by the value of sum of the two.
The computing formula of scattering ratio is as follows:
R=[(C-T)/(C+T)]×100%
R represents scattering ratio, and C represents that monomorium pharaonis is through contrast buckwheat number of times, and T represents that monomorium pharaonis is through processing buckwheat number of times.
Use respectively the N of variable concentrations, N-dimethyl hydrogenation promise foretell amide reagent by above-mentioned steps to monomorium pharaonis repeated test, calculate scattering ratio (%) data under variable concentrations as shown in table 2.As can be seen from Table 2, N, N-dimethyl hydrogenation promise is foretold acid amides, under variable concentrations, monomorium pharaonis has all been shown to certain scattering ratio, and repellent activity improves with the increase of concentration.
Table 2 variable concentrations N, the repellent activity of acid amides to monomorium pharaonis foretold in N-dimethyl hydrogenation promise
Test shows, N, and N-dimethyl hydrogenation promise is foretold acid amides monomorium pharaonis is had to good repellent activity, can be used as ant repellant.
Embodiment 2N, the repellant test of acid amides as cockroach foretold in N-dimethyl hydrogenation promise
With absolute ethyl alcohol, by N, N-dimethyl hydrogenation promise fore-telling acid amides is configured to the solution of 12.5,25,50,100 (mg/g) variable concentrations.The filter paper that is 9cm by diameter is on average cut into two sheets, wherein half certain density N of filter paper of a slice, and N-dimethyl hydrogenation promise is foretold amide solution and is soaked into, and half filter paper of another sheet in contrast, soaks into absolute ethyl alcohol.
Two and half filter paper are taken out and dried, after 5 minutes, smearing edge respectively with solid glue, and be attached to symmetrically the culture dish inner bottom surface that diameter is 20cm, is the clear area without filter paper between the two, the central authorities of ware lid offer the square hole of a 2cm × 2cm, cover ware lid stand-by.
1 Groton bug is introduced to the clear area of culture dish, after 5min, recorded respectively the time that Groton bug stops on two filter paper, observe 5min (300s).The time that Groton bug rests on clear area is not counted in contrast or processes in the time of staying on filter paper, but counts in total time (300s).Each concentration in triplicate, is asked scattering ratio mean value.Test is controlled at 26 ± 1 ℃ in temperature, and carry out in the laboratory of relative moisture 65 ± 5%.
Groton bug is scattering ratio (%) in contrast filter paper and the difference of processing the time stopping on filter paper divided by the value of always seeing.
Its scattering ratio computing formula is as follows:
Scattering ratio (%)=[(on contrast filter paper on the time of staying-processing filter paper the time of staying)/300] × 100%
The calculated data of scattering ratio is as shown in table 3.
Table 3 variable concentrations N, the repellent activity of acid amides to Groton bug foretold in N-dimethyl hydrogenation promise
Result of the test shows, N, and N-dimethyl hydrogenation promise is foretold acid amides Groton bug is had to good repellent activity, can be used as cockroach repellant.
Application examples 1
The refrigerator bottom of often assembling dining room, kitchen cockroach, investigation 3 times before dispenser, on average finds respectively 9 of cockroaches and 7, sprays the N of 100mg/g, N-dimethyl hydrogenation promise fore-telling acid amides, random observation cockroach quantity.Observe the cockroach number of the 1st, 2,3 days of finding after dispenser and be respectively 0,0,3, repellent effect is obvious.
Application examples 2
In the carton of books in stock, before dispenser, find 12 of cockroaches, spray the N of 100mg/g, N-dimethyl hydrogenation promise is foretold after acid amides, in 5 days, finds no cockroach, and repellent effect is remarkable.
The preferred embodiment of the present invention, it should be pointed out that for those skilled in the art, not departing under the prerequisite of the technology of the present invention principle, can also make some improvement and modification, and these improve and modification also should be considered as protection scope of the present invention.
Claims (2)
1. a N, N-dimethyl hydrogenation promise is foretold acid amides as the application of insect repellent, it is characterized in that: comprise N, N-dimethyl hydrogenation promise is foretold acid amides respectively as the application of ant and cockroach repellant.
2. N according to claim 1, the application of acid amides as insect repellent foretold in N-dimethyl hydrogenation promise, it is characterized in that: N, when N-dimethyl hydrogenation promise fore-telling amide concentration is 100mg/g, is respectively 100% and 69% to the scattering ratio of ant and cockroach.
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Cited By (1)
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CN104920511A (en) * | 2015-05-08 | 2015-09-23 | 吴持跃 | Ant repellent, and preparation method and application thereof |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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US5221535A (en) * | 1989-11-13 | 1993-06-22 | Nova Pharmaceutical Corporation | Sustained release formulations of insect repellent |
JPH0824321A (en) * | 1994-07-13 | 1996-01-30 | Suzuki Sogyo Co Ltd | Deodorant, antimicrobial and pest-repellent foam and its production |
CN103420944A (en) * | 2013-07-26 | 2013-12-04 | 江西农业大学 | Method for synthesizing cis-hydronopyl formamide compounds |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5221535A (en) * | 1989-11-13 | 1993-06-22 | Nova Pharmaceutical Corporation | Sustained release formulations of insect repellent |
JPH0824321A (en) * | 1994-07-13 | 1996-01-30 | Suzuki Sogyo Co Ltd | Deodorant, antimicrobial and pest-repellent foam and its production |
CN103420944A (en) * | 2013-07-26 | 2013-12-04 | 江西农业大学 | Method for synthesizing cis-hydronopyl formamide compounds |
Non-Patent Citations (1)
Title |
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赵玲华: ""氢化诺卜醇及其衍生物的合成与生物活性研究"", 《江西农业大学硕士学位论文》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104920511A (en) * | 2015-05-08 | 2015-09-23 | 吴持跃 | Ant repellent, and preparation method and application thereof |
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