CN103800076B - A kind of structure-optics-nucleic multi-mode imaging system and method - Google Patents
A kind of structure-optics-nucleic multi-mode imaging system and method Download PDFInfo
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Abstract
The invention discloses a kind of structure-optics-nucleic multi-mode imaging system, this system comprises: base for supporting, is fixed on ground, for supporting line slideway, disk and rotation platform; Rotation platform, is provided with CT system and fluoroscopic imaging systems; Disk, is provided with PET system; Support, is installed on line slideway; Object platform to be imaged, is fixed on support; CT system, for gathering the cross sectional anatomy structural images of object to be imaged; Fluoroscopic imaging systems, for gathering the two-dimensional fluoroscopic image of object to be imaged; PET system, for gathering the PET image of object to be imaged; Computer, receives image and processes it, obtaining the 3-D view of object to be imaged.The present invention also proposes a kind of structure-optics-nucleic multi-modality imaging method.The present invention can be used for waiting for that imaging object carries out the same machine fusion three-dimensional optical imaging of structure-optics-nucleic to toy in pre-clinical experiment.
Description
Technical field
The present invention relates to optical molecular imaging technical field, particularly a kind of structure-optics-nucleic multi-mode imaging system and method.
Background technology
In recent years, along with the develop rapidly of optical molecular Imaging Technology, some are applied to the imaging technique of medical science, as CT, ultrasonic, magnetic resonance, radionuclide imaging, positron emission computerized tomography (PET), and the fusion of imaging technology such as PET/CT plays an important role in life sciences and pre-clinical research.CT imaging resolution is high, does not have imaging depth to limit, and can provide anatomical information, but can not carry out good imaging to soft tissue.Fluorescence fault imaging (FMT) utilizes optical molecular probe, physiology and pathology detection are carried out to the target tissue of probe, the fluorescence that autofluorescence fault imaging (BLT) utilizes organism self to send carries out imaging, when Cherenkov's fault imaging (CLT) utilizes radionuclide charged particle movement velocity in its medium of producing in the process decayed to be greater than light movement velocity in the medium, the Cherenkov light produced carries out imaging, but the method for these optical imageries, imaging depth is shallow, and resolution is lower.PET imaging has good specificity, and can provide functional metabolism information, but its sensitivity and resolution lower.How can by multiple modalities imaging device fusion of imaging, the information based on each Modal detection carries out fusion of imaging, thus the deficiency overcoming the information such as physiology, pathology and the structure that single mode provides is the focus of optical molecular iconography research always.
There is a lot of research institution both at home and abroad by a lot of ripe single mode system, as fusion of imaging is carried out in CT, PET, FMT and magnetic resonance (MRI) etc., thus obtain the much information of tested organism.AngeliqueA etc. apply FMT/CT emerging system and detect mice cervical region and lung tumors, and result shows, and the FMT result having merged CT information is more accurate.LiC etc. build a kind of FMT/PET system, provide a kind of system and method for FMT and PET double-mode imaging.In addition, the people such as NahrendorfM utilize business PET/CT and FMT to carry out mice imaging in vivo, and mobile animal storehouse of placing mice, carries out each modality according to this.In this system and imaging mode, because mice needs mobile, posture and the change in location of some mices will certainly be caused, can impact final imaging.At present, the system of two kinds of mode can accomplish same machine imaging, but the optical molecular imaging system of most three kinds of mode or more is that toy is carried out imaging respectively in each modal system, and then is merged by image.The mode of above-mentioned multi-modal fusion imaging, toy is waited for, and the position of imaging object produces change in moving process.Therefore, the image obtained needs to correct through algorithm, has so both added the time of rebuilding image, and the quality of rebuilding image is also difficult to be guaranteed.
Summary of the invention
In order to solve above-mentioned problems of the prior art, the present invention proposes a kind of structure-optics-nucleic multi-mode imaging system and method, the present invention is to be generally used for the CT system in the single modality of toy wait imaging object, fluoroscopic imaging systems and PET imaging system are basic equipment, the multi-modality imaging method of PET imaging is merged for core with a kind of same machine, the structure of object to be imaged is gathered with machine, optics-nuclide chart picture, and the two dimensional image collected is carried out three-dimensional reconstruction through graphics processing card, thus obtain physiology and the pathology three-dimensional fusion image of object to be imaged.
According to an aspect of the present invention, a kind of structure-optics-nucleic multi-mode imaging system is proposed, this system comprises: base for supporting, rotation platform, CT system, fluoroscopic imaging systems, PET system, disk, line slideway, object platform to be imaged, support and computer, wherein:
Described base for supporting is fixed on ground;
Described rotation platform is arranged on one end of described base for supporting perpendicular to ground, the center of its center of rotation and object to be imaged is in same level line, the surface of described rotation platform is provided with evenly distributedly described CT system and fluoroscopic imaging systems, for rotating according to the imaging requirements of CT system and fluoroscopic imaging systems;
Described CT system is connected with described computer by CT dedicated data line, for continuously gathering the cross sectional anatomy structural images of object to be imaged in rotation platform rotary course, and the cross sectional anatomy structural images collected is transferred in described computer carries out processing and preserving;
Described fluoroscopic imaging systems is connected with described computer by USB or serial interface data line, for rotate to fixed angle stopping at rotation platform after, continuously detect the fluorescence signal in object body to be imaged, obtain two-dimensional fluoroscopic image, and the fluoroscopic image collected is transferred in described computer carries out processing and preserving;
Described disk is arranged on the front of described rotation platform perpendicular to ground, and the center of its center of rotation and object to be imaged is in same level line, the surface of described disk is provided with described PET system;
Described PET system is connected with described computer by pet detector dedicated data line, for fix at described disk and pet detector formed closed area time, continuously gather the PET image of object to be imaged, and the PET image obtained is transferred in described computer carry out processing and preserving;
Described line slideway is arranged on the upper surface of described base for supporting, and described line slideway is provided with Communications Control Interface, for connecting described computer, to move according to the control instruction of described computer;
Described support installing is on described line slideway;
Described object platform to be imaged is fixed on described support, for placing object to be imaged;
Described computer, for receiving the image of described CT system, fluoroscopic imaging systems and PET system transmission and preserving it and process, finally obtains the 3-D view of object to be imaged.
According to a further aspect in the invention, propose a kind of structure-optics-nucleic multi-modality imaging method, the method comprises the following steps:
Step 1, computer controls line slideway and moves object platform to be imaged, the center of object to be imaged is moved to the center of pet detector, starts to treat imaging object and carry out PET imaging, obtain PET image data, and described PET image data are transferred in described computer store;
Step 2, computer controls line slideway and moves object platform to be imaged, the center of object to be imaged is moved to the center of rotation platform, fluoroscopic imaging systems is started working, open laser instrument, be irradiated to by laser on object to be imaged, CCD camera continuously gathers the fluorescence signal sent in object body to be imaged, obtain two-dimensional fluoroscopic image, described two-dimensional fluoroscopic image is transferred in described computer and stores;
Step 3, after described fluoroscopic imaging systems has gathered a width two-dimensional fluoroscopic image, rotation platform starts to rotate, CT system starts the cross sectional anatomy structural images of continuous acquisition object to be imaged simultaneously, and the cross sectional anatomy structural image data obtained is transferred in described computer carry out processing and storing, stop after rotation platform half-twist;
Step 4, the image acquisition of fluoroscopic imaging systems and CT system in repeating said steps 2 and step 3, until rotation platform rotating 360 degrees completes the collection of all two-dimensional fluoroscopic image and cross sectional anatomy structural images;
Step 5, described computer processes all two dimensional images obtained, and utilizes the 3-D view of two-dimension image rebuild object to be imaged, and preserves it.
Due in whole imaging process, toy waits for that imaging object is fixed on object platform to be imaged all the time, three kinds of image modes are treated imaging object all angles and are carried out fault imaging, eventually pass graphics processing card and three-dimensional reconstruction is carried out to two dimensional image, the image of multiple modalities can by respective mutual supplement with each other's advantages, overcome the deficiency of single mode, improve picture quality.Therefore, the present invention can be used for the optical molecular imaging merging PET in the experiment of pre-clinical toy wait imaging object with machine.
Accompanying drawing explanation
Fig. 1 is the structural representation of structure-optics-nucleic multi-mode imaging system of the present invention;
Fig. 2 is the flow chart of structure-optics of the present invention-nucleic multi-modality imaging method.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearly understand, below in conjunction with specific embodiment, and with reference to accompanying drawing, the present invention is described in more detail.
Fig. 1 is the structural representation of Optical multi-mode state imaging system of the present invention, as shown in Figure 1, described Optical multi-mode state imaging system comprises: rotation platform 1, CT system, fluoroscopic imaging systems, PET system, disk 7, object platform 9 to be imaged, support 10, line slideway 11, base for supporting 12 and computer, wherein:
Described base for supporting 12 is fixed on ground, it is provided with described line slideway 11, disk 7 and rotation platform 1;
Described rotation platform 1 is arranged on one end of described base for supporting 12 perpendicular to ground, the center of its center of rotation and object to be imaged is in same level line, the surface of described rotation platform 6 is provided with described CT system and fluoroscopic imaging systems evenly distributedly, for rotating according to the imaging requirements of CT system and fluoroscopic imaging systems;
Described disk 7 is arranged on the front of described rotation platform 1 perpendicular to ground, and the center of its center of rotation and object to be imaged is in same level line, and the surface of described disk 7 is provided with described PET system;
Described line slideway 11 is arranged on the upper surface of described base for supporting 12, for support 10 mobile mounted thereto; Described line slideway 11 is provided with Communications Control Interface, for connecting described computer, moves with the control instruction sent according to described computer;
Described support 10 is installed on described line slideway 11;
Described object platform 9 to be imaged is fixed on described support 10, for placing object to be imaged;
Described rotation platform 1 is provided with: CCD camera 2, laser instrument 5, X-ray tube 4, X-ray detector 3, multiple rectilinear translation platform 6, wherein:
Described multiple rectilinear translation platform 6 is installed on rotation platform 1, and orthogonal thereto layout, for carrying CT system and fluoroscopic imaging systems, described rectilinear translation platform 6 is provided with Communications Control Interface, be connected with described computer, to move according to the control instruction of described computer;
Described CT system is connected with described computer by CT dedicated data line, for continuously gathering the cross sectional anatomy structural images of object to be imaged in rotation platform 1 rotary course, and the cross sectional anatomy structural images collected is transferred in described computer carries out processing and preserving;
Described CT system comprises X-ray tube 4 and X-ray detector 3, wherein, X-ray tube 4 and X-ray detector 3 are mounted opposite on described rotation platform 1, the center of the ray mouth of described X-ray tube 4, object center to be imaged and X-ray detector 3 is on same straight line, to ensure CT picture quality;
Described fluoroscopic imaging systems is connected with described computer by USB or serial interface data line, for rotate to fixed angle stopping at rotation platform 1 after, continuously detect the fluorescence signal in object body to be imaged, obtain two-dimensional fluoroscopic image, and the fluoroscopic image collected is transferred in described computer carries out processing and preserving;
Described fluoroscopic imaging systems comprises laser instrument 5 and CCD camera 2, wherein, laser instrument 5 and CCD camera 2 are mounted opposite on rotation platform 1, the visual field of described CCD camera 2 needs to comprise object whole body to be imaged completely, the laser that laser instrument 5 sends is irradiated on object to be imaged, produces fluorescence excitation, the fluorescence signal now in CCD camera 2 continuous detecting object body to be imaged in object body to be imaged, form a width two-dimensional fluoroscopic image, and be transferred in described computer;
Described PET system is connected with described computer by pet detector dedicated data line, for when described disk 7 is fixing and pet detector 8 forms closed area, continuously gather the PET image of object to be imaged, and the PET image obtained is transferred in described computer carry out processing and preserving;
Described PET system comprises multiple pet detector 8, the quantity of described pet detector is even-even, and be no less than four groups, described multiple pet detector 8 can form closed area and the imaging center position of its imaging center position and described rotation platform 1 is on same straight line, described pet detector 8 is installed on described disk 7, gammaphoton is radiated after injection radiosiotope in object body to be imaged, move pet detector 8 by disk 7 and form closed area, pet detector 8 detects by the gammaphoton sent in object body to be imaged, PET image is obtained after opto-electronic conversion, and obtained PET image is transferred in described computer,
Described computer is provided with graphics processing card and can supports figure parallel computation, described graphics processing card and line slideway 11, rectilinear translation platform 6, CT system, fluoroscopic imaging systems is connected with PET system, for continuously gathering the image that each imaging system obtains, and the image collected is processed, such as position registration, image co-registration etc., be 3-D view by two-dimension image rebuild, namely described computer receives described CT system, the image that fluoroscopic imaging systems and PET system send also is preserved it and processes, finally obtain the 3-D view of object to be imaged,
The communication control interface for connecting line slideway 11 and rectilinear translation platform 6 described computer is also equipped with, this interface can be USB interface or serial line interface, these interfaces are connected with rectilinear translation platform 6 with line slideway 11 by USB line or string line, its kinematic parameter can be read from line slideway 11 and rectilinear translation platform 6, such as position and speed parameter, and the parameter of acquisition is returned described computer, described computer sends control instruction according to the parameter obtained, and control line slideway 11 and rectilinear translation platform 6 move.
Fig. 2 is the flow chart of multi-modality imaging method of the present invention, and as shown in Figure 2, described multi-modality imaging method comprises the following steps:
Step 1, computer controls line slideway and moves object platform to be imaged, the center of object to be imaged is moved to the center of pet detector, starts to treat imaging object and carry out PET imaging, obtain PET image data, and described PET image data are transferred in described computer store;
Step 2, computer controls line slideway and moves object platform to be imaged, the center of object to be imaged is moved to the center of rotation platform, fluoroscopic imaging systems is started working, open laser instrument, be irradiated to by laser on object to be imaged, CCD camera continuously gathers the fluorescence signal sent in object body to be imaged, obtain two-dimensional fluoroscopic image, described two-dimensional fluoroscopic image is transferred in described computer and stores;
Step 3, after described fluoroscopic imaging systems has gathered a width two-dimensional fluoroscopic image, rotation platform starts to rotate, CT system starts the cross sectional anatomy structural images of continuous acquisition object to be imaged simultaneously, and the cross sectional anatomy structural image data obtained is transferred in described computer carry out processing and storing, stop after rotation platform half-twist;
Step 4, the image acquisition of fluoroscopic imaging systems and CT system in repeating said steps 2 and step 3, until rotation platform rotating 360 degrees completes the collection of all two-dimensional fluoroscopic image and cross sectional anatomy structural images;
Step 5, described computer processes all two dimensional images obtained, utilize the 3-D view of two-dimension image rebuild object to be imaged, and it is preserved, so far complete multi-modality images collection and reconstruction, terminate, wherein, described process includes but not limited to position registration, the image procossing such as image co-registration.
Wherein, the image acquisition of PET system also can be carried out before the imaging system acquires of other mode after the imaging system acquires of other mode terminates.
Above-described specific embodiment; object of the present invention, technical scheme and beneficial effect are further described; be understood that; the foregoing is only specific embodiments of the invention; be not limited to the present invention; within the spirit and principles in the present invention all, any amendment made, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (9)
1. structure-optics-nucleic multi-mode imaging system, it is characterized in that, this system comprises: base for supporting, rotation platform, CT system, fluoroscopic imaging systems, PET system, disk, line slideway, object platform to be imaged, support and computer, wherein:
Described base for supporting is fixed on ground;
Described rotation platform is arranged on one end of described base for supporting perpendicular to ground, the center of its center of rotation and object to be imaged is in same level line, the surface of described rotation platform is provided with evenly distributedly described CT system and fluoroscopic imaging systems, for rotating according to the imaging requirements of CT system and fluoroscopic imaging systems;
Described CT system is connected with described computer by CT dedicated data line, for continuously gathering the cross sectional anatomy structural images of object to be imaged in rotation platform rotary course, and the cross sectional anatomy structural images collected is transferred in described computer carries out processing and preserving;
Described fluoroscopic imaging systems is connected with described computer by USB or serial interface data line, for rotate to fixed angle stopping at rotation platform after, continuously detect the fluorescence signal in object body to be imaged, obtain two-dimensional fluoroscopic image, and the fluoroscopic image collected is transferred in described computer carries out processing and preserving;
Described disk is arranged on the front of described rotation platform perpendicular to ground, and the center of its center of rotation and object to be imaged is in same level line, the surface of described disk is provided with described PET system;
Described PET system is connected with described computer by pet detector dedicated data line, for fix at described disk and pet detector formed closed area time, continuously gather the PET image of object to be imaged, and the PET image obtained is transferred in described computer carry out processing and preserving, wherein, described PET system comprises multiple pet detector, and described multiple pet detector can form closed area and the imaging center position of its imaging center position and described rotation platform is on same straight line;
Described line slideway is arranged on the upper surface of described base for supporting, and described line slideway is provided with Communications Control Interface, for connecting described computer, to move according to the control instruction of described computer;
Described support installing is on described line slideway;
Described object platform to be imaged is fixed on described support, for placing object to be imaged;
Described computer is provided with graphics processing card and can supports figure parallel computation, described graphics processing card is connected with PET system with line slideway, rectilinear translation platform, CT system, fluoroscopic imaging systems, for receiving the image of described CT system, fluoroscopic imaging systems and PET system transmission and preserving it and process, finally obtain the 3-D view of object to be imaged.
2. system according to claim 1, it is characterized in that, described rotation platform is provided with: CCD camera, laser instrument, X-ray tube, X-ray detector and multiple rectilinear translation platform, wherein, described multiple rectilinear translation platform is installed on rotation platform, and orthogonal thereto layout, for carrying CT system and fluoroscopic imaging systems.
3. system according to claim 2, is characterized in that, described rectilinear translation platform is provided with Communications Control Interface, is connected with described computer, to move according to the control instruction of described computer.
4. system according to claim 2, it is characterized in that, described CT system comprises X-ray tube and X-ray detector, wherein, X-ray tube and X-ray detector are mounted opposite on described rotation platform, and the center of the ray mouth of described X-ray tube, object center to be imaged and X-ray detector is on same straight line.
5. system according to claim 2, it is characterized in that, described fluoroscopic imaging systems comprises laser instrument and CCD camera, wherein, laser instrument and CCD camera are mounted opposite on rotation platform, and the visual field of described CCD camera comprises object whole body to be imaged completely, the laser that laser instrument sends is irradiated on object to be imaged, produce fluorescence excitation in object body to be imaged, the fluorescence signal in CCD camera continuous detecting object body to be imaged, forms a width two-dimensional fluoroscopic image.
6. system according to claim 1, it is characterized in that, described pet detector is installed on described disk, gammaphoton is radiated after injection radiosiotope in object body to be imaged, move pet detector by disk and form closed area, pet detector detects by the gammaphoton sent in object body to be imaged, after opto-electronic conversion, obtain PET image.
7. system according to claim 6, is characterized in that, the quantity of described pet detector is even-even, and is no less than four groups.
8. system according to claim 2, it is characterized in that, described computer is connected with rectilinear translation platform with line slideway by communication control interface, reads its kinematic parameter, described computer sends control instruction according to the kinematic parameter obtained, and control line slideway and rectilinear translation platform move.
9. structure-optics-nucleic multi-modality imaging method, it is characterized in that, the method comprises the following steps:
Step 1, computer controls line slideway and moves object platform to be imaged, the center of object to be imaged is moved to the center of pet detector, start to treat imaging object and carry out PET imaging, obtain PET image data, and described PET image data are transferred in described computer store, wherein, described pet detector is multiple, and described multiple pet detector can form closed area and the imaging center position of its imaging center position and rotation platform is on same straight line;
Step 2, computer controls line slideway and moves object platform to be imaged, the center of object to be imaged is moved to the center of rotation platform, fluoroscopic imaging systems is started working, open laser instrument, be irradiated to by laser on object to be imaged, CCD camera continuously gathers the fluorescence signal sent in object body to be imaged, obtain two-dimensional fluoroscopic image, described two-dimensional fluoroscopic image is transferred in described computer and stores;
Step 3, after described fluoroscopic imaging systems has gathered a width two-dimensional fluoroscopic image, rotation platform starts to rotate, CT system starts the cross sectional anatomy structural images of continuous acquisition object to be imaged simultaneously, and the cross sectional anatomy structural image data obtained is transferred in described computer carry out processing and storing, stop after rotation platform half-twist;
Step 4, the image acquisition of fluoroscopic imaging systems and CT system in repeating said steps 2 and step 3, until rotation platform rotating 360 degrees completes the collection of all two-dimensional fluoroscopic image and cross sectional anatomy structural images;
Step 5, described computer is provided with graphics processing card and can supports figure parallel computation, described graphics processing card is connected with PET system with line slideway, rectilinear translation platform, CT system, fluoroscopic imaging systems, all two dimensional images obtained are processed, utilize the 3-D view of two-dimension image rebuild object to be imaged, and it is preserved.
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| CN102488493A (en) * | 2011-11-15 | 2012-06-13 | 西安电子科技大学 | Small animal living body multi-mode molecule imaging system and imaging method |
| CN102764138A (en) * | 2012-08-02 | 2012-11-07 | 北京大学 | Multi-mode little animal molecular image imaging device and imaging method |
| CN103082997A (en) * | 2013-01-28 | 2013-05-08 | 中国科学院自动化研究所 | System and method of drum-type multimode integration three-dimensional tomography |
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