CN103715192B - A kind of biosensor platform chip and integrated approach - Google Patents
A kind of biosensor platform chip and integrated approach Download PDFInfo
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- CN103715192B CN103715192B CN201310277528.9A CN201310277528A CN103715192B CN 103715192 B CN103715192 B CN 103715192B CN 201310277528 A CN201310277528 A CN 201310277528A CN 103715192 B CN103715192 B CN 103715192B
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Abstract
The present invention relates to a kind of biosensor platform chip and integrated approaches.The large scale integrated circuit CMOS technology of the technology maturation, a biosensor platform chip is made, and then is all kinds of different biosensors, unified an integrated platform and interface are provided, complicated independent special designing is avoided to manufacture, realization simply and effectively integrates.The integrated collected biological sample of biosensor is carried out digitized processing by the present invention, and by wireless data and power supply technique, realizes high-speed sampling, wireless transmission, external storage, the flexible detection and analysis of a large amount of biological datas.The wireless platform chip of this technology is not limited only to integrate single microbiosensor, and combines the encapsulation of bio-compatible, to realize effective implantable product；It could be applicable to external, integrated on a printed circuit jointly with a variety of biosensors, it, can a variety of different biological samples of collection analysis simultaneously to form one " miniature laboratory ".
Description
Technical field
The present invention relates to a kind of biosensor platform chip and integrated approaches.The technology using cheap, technology at
Ripe CMOS technology provides the unified chip platform and connect that one is advantageously integrated for various types of biosensor
Mouthful；And by wireless data and power supply technique, the high speed acquisitions of a large amount of biological datas, wireless transmission, external storage, flexibly are realized
Detection and analysis.
Technical background
Biosensor be with bioactive materials (enzyme, protein, DNA, antibody, antigen, biomembrane etc.) with it is physico
The cross discipline that energy converter organically combines is learned, is to develop a kind of essential advanced detection method of biotechnology and prison
Quick, the micro-analysis method of prosecutor method and material molecule level.Clinic of the biosensor technology in national economy is examined
Disconnected, Industry Control, food and Pharmaceutical Analysis (including bio-pharmaceutical research and development), environmental protection and biotechnology, biological core
It has a wide range of applications in the research such as piece.At this stage, various biosensor products are each in form, size, design
From there is greatly difference, substantially also only rest on to specifically apply and the stage of special designing manufacture, and implantable
Biologic sensor chip is even more very few.In general, biosensor utilizes the acceptor device and sensing of its special manufacture
Device after acquiring biological sample, needs to digitize sample using subsequent signal processing and digital processing circuit, Cai Nengjin
Row effectively reads and analyzes.In the situation done things in his own way at present, each specific application requires to redesign for it
And corresponding signal processing and digital processing circuit are manufactured, to waste a large amount of human and material resources and time.Simultaneously as lacking
The support of weary wireless data and power supply technique, traditional unavoidable electric wire of biosensor product and battery, cause size mistake
It cannot achieve implantation greatly.The micro radio biologic sensor chip of specific application also exists only in the experiment of research institution at present
In room.In order to break through this situation, the present invention creates the concept of biosensor platform chip in due course, and utilization is cheap,
The CMOS technology of technology maturation, a general platform and interface can be provided for integrated different kind organism sensor by having made one
Wireless chip technology.
Summary of the invention
The purpose of the present invention is to provide a kind of biosensor platform chip and integrated approaches, and then are all kinds of different
Biosensor, including electrochemical sensor, visible light sensor, Magnetic Sensor, heat sensor etc., provide one it is unified
Integrated platform and interface avoid complicated independent special designing from manufacturing, and realization simply and effectively integrates.By using extensive collection
At the CMOS chip of circuit design, the present invention carries out integrated biosensor collected biological sample at digitlization
Reason, and by wireless data and power supply technique realizes the high-speed samplings of a large amount of biological datas, wireless transmission, external storage, flexibly
Detection and analysis.The scope of application of the present invention includes but are not limited on wireless platform chip integrate single miniature organism sensing
Device, and the encapsulation of bio-compatible is combined, to realize effective implantable product.This technology could be applicable in vitro, incite somebody to action this
Platform chip and a variety of biosensors are integrated on a printed circuit, to form one " miniature laboratory ", can acquire point
Analyse a variety of different biological samples.This " miniature laboratory " is used in environmental protection aspect, it can be achieved that the comprehensive of various environmental parameters
It closes and tests and analyzes；If being used for family, " family doctor " can be become, realize to various common biological parameters (such as blood pressure, pulse,
Blood glucose, blood routine etc.) facilitate detection and analysis and historical record track and alarm etc..
A kind of biosensor platform chip provided by the invention and the technical solution of integrated approach are: a kind of bio-sensing
Device platform chip, including it is independent multichannel input interface, low noise pre-amplification circuit (Low-Noise-Preamplifier), more
Paths selection circuit (Multiplexer), is patrolled at analog to digital conversion circuit (Analog to Digital Converter, ADC)
Collect control circuit (Digital Controller), storage inside circuit (Memory), wireless receiver circuit
(Wireless Transceiver), wireless power circuit (Wireless Power Recovery).This platform chip will be above-mentioned
Circuit module is integrated on one chip by way of large scale integrated circuit, to be various types of bio-sensing
Device provides a unified biosensor and provides unified a platform and interface.
Preferably, the biosensor platform chip uses complementary metal oxide semiconductor CMOS
The manufacture of (Complementary Metal Oxide Semiconductors) Technology design.CMOS technology is cheap, design
With manufacturing technology maturation, performance is stablized, is quickly grown, therefore is the first choice of large scale integrated chip standardization, micromation,
It is also the first choice of biosensor platform chip of the present invention.
Preferably, the independent input that the independent multichannel input interface possesses high density (i.e. quantity reaches up to a hundred) is logical
Road can be used for acquiring different biological samples, or the sample of acquisition different zones；The numerous sample of collecting quantity is detected simultaneously
Working efficiency can be significantly greatly increased in analysis, and guarantees the reliability of testing result；To reach chip high density, the requirement of small size,
It is an effective means using nanoscale CMOS technology.
Preferably, the multiplexer channel selection circuit is under the control of logic control circuit, only for different applications
The channel used required for selecting；The high density channel that platform chip i.e. of the present invention is possessed can might not all be made
With the channel for having different number is idle in different applications；Chip is by receiving external set to the selection in channel
Standby order and configuration information is configured；This design has great flexibility, so that in a unified platform chip
On can integrate the biosensor of different type, different number, to successfully avoid complicated independent special of different product
Different design.
Preferably, analog-digital conversion circuit as described timing according to provided by the logic control circuit and order are in an orderly manner
The sample of multiple acquisition channels is converted into digital signal；This analog to digital conversion circuit should have larger dynamic input range to meet
The specification demands of different sensors.
Preferably, the sample rate of analog-digital conversion circuit as described has reasonable biggish dynamic select range, can pass through
It is that different sample rates is arranged in different channels that external command, which sends configuration information,；This design can be advantageously applied to work as this platform
The multiple biosensors of integrated chip, and requirement of the different input channels to the sample rate of different biological samples have compared with
The case where big difference.
Preferably, the logic control circuit is responsible for selection and timing control of the multiplexer channel selection circuit to channel；
It is responsible for the setting of analog to digital conversion circuit sample frequency；It is responsible for handling the reading of data and packing from internal storage；It is responsible for
With the communication of wireless receiver circuit；Logic control circuit remove by normal mode it is orderly successively collect used input
Except the sample in channel, the switch control that any duration is carried out to any input channel can also be realized by ordering；This is
The design for arranging the logic control circuit of intelligence provides great flexibility and safety, can be directed to different application and requirement
This platform chip is controlled and is adjusted.
Preferably, the storage inside circuit is temporarily stored the digital signal that each channel is converted to；This
Design can be such that multiplexer channel selection circuit and analog to digital conversion circuit samples with faster rate, but chip can be with lower data
Rate sends data to external equipment.
Preferably, the wireless receiver circuit will be as needed, different transmission frequencies and agreement are used: as
Implantable products can be using medical treatment implantation Communications service frequency range (Medical Implant Communication Service
Band, MICS) or inductive coupling mode (Inductive Coupling) docked with the external equipment of same protocol is taken；Make
For non-built-in mode product, IEEE802.11 agreement or Bluetooth technology and external smart equipment Direct Communication can be taken；This design
Chip a large amount of biological datas collected are wirelessly transmitted to external equipment to be stored, detected, analyzed and alarmed.
Preferably, the wireless power circuit, can use coil coupled modes and carries out wireless power to entire chip,
To use in integrated implantable products, operation implantation battery and electric wire are avoided；Meanwhile also to provide DC power supply straight for this circuit
Connect input interface；As non-built-in mode product in use, battery or DC power supply can be taken directly to power.
Preferably, all the above circuit module is integrated in chip piece by way of large scale integrated circuit
On, a unified platform and interface is provided for various types of biosensor, to form bio-sensing of the present invention
Device platform chip；By highdensity acquisition channel and extremely flexible PLC technology, and carry mature wireless data
With power delivery technology, the present invention is truly realized the simple and effective integrated of the biosensor of different type, quantity, provides
Safe and reliable implanted scheme and flexible and convenient non-built-in mode scheme realize high while a large amount of different biological datas
Fast acquisition, the analysis of wireless transmission, external storage, real-time detection, historical record tracking and alarm；The present invention will be greatly promoted phase
Close the development of field technology.
The present invention provides a kind of integrated working method of biosensor platform chip, comprising the following steps:
A, single or multiple biosensors are integrated in this platform chip, i.e., by the output channel of biosensor and this
The independent multichannel input interface of platform chip is attached；
B, the sensor integrated, by the sensor sensing device contacted with bioactive materials, to acquire biological work
Electrochemical signals, visible light signal, magnetic signal or thermal signal caused by property material etc., and micro- electricity is converted by these signals
Signal；
C, by chip provide low noise pre-amplification circuit come generate with each channel micro- electric signal collected at than
" amplified signal " of example；
D, each paths are selected according to certain timing by the multiplexer channel selection circuit that chip provides in an orderly manner
" amplified signal ", pass it to analog to digital conversion circuit；
E, " amplified signal " is converted into counting by sample rate provided by analog to digital conversion circuit logically control circuit
Word signal is simultaneously stored in internal storage；
F, the logic control circuit and wireless receiver circuit for providing the digital signal in memory by chip
It is sent to external equipment (smart machines such as special external equipment or computer, smart phone, palm PC) progress in an orderly manner
Analysis and display, and store the data storage for arriving external equipment.
Preferably, the quantity of the independent multichannel input interface in step a, should have highdensity requirement (i.e. quantity
Reach up to a hundred)；For different application, only the input interface of respective numbers need to be selected according to the number of the interface used in it, and
Change corresponding interface panel (pad) as needed in the location layout of chip surface metal layer；The quantity of input interface
It may be programmed and (set by external command with specific channel selecting
The input interface of quantity is answered, and changes corresponding interface panel (pad) as needed in chip surface metal layer
Location layout；The quantity of input interface and specific channel selecting may be programmed (being arranged by external command).
Preferably, single biosensor and biosensor platform chip in step a, as implantable products
It is integrated integrated using chip (flip-chip) binding technology is inverted；Independence used in biosensor platform chip at this time
The number of multichannel input interface and its position for being located at chip by institute's integral biosensor output channel (interface)
Number and relative position determine；Complete the encapsulation for taking closed bio-compatible after integrating again, it can by safely and effectively
It implants.
Preferably, multiple biosensors and biosensor platform core in step a, as non-built-in mode product
The integrated of piece is integrated using printed circuit board.Biosensor platform chip can be first packaged to be advantageously integrated at this time；This
When biosensor platform chip used in independent multichannel input interface number by institute's integral biosensor number
And the number of its output channel (interface) determines.
Preferably, should have low noise, low-power consumption, the suppression of high common mode in step c per low noise pre-amplification circuit all the way
System changes the characteristics such as small with flow-route and temperature than (CMRR), high PSRR (PSRR), performance.
Preferably, multiplexer channel selection circuit in step the d logically pre-set sequence of control circuit and frequency
Rate (duration) selects " amplified signal " in channel all the way and inputs to analog to digital conversion circuit；Multiplexer channel selection circuit is in logic
The channel used required for different applications only selects is directed under the control of control circuit；The sequence and frequency of this access selection
(duration) can change setting by receiving order and the configuration information of external equipment by logic control circuit.
Preferably, analog to digital conversion circuit in step e logically the pre-set sample rate of control circuit to selected
" amplified signal " for selecting channel is sampled and is converted to digital signal；The sample rate of usual analog to digital conversion circuit should compare multiple pass
The frequency of road selection circuit selector channel is much higher, so that every paths collect enough sample points；Sample rate can be by patrolling
Control circuit is collected by receiving order and the configuration information of external equipment to change setting.
It, can be with preferably, the sample rate of the analog to digital conversion circuit in step e has reasonable biggish dynamic select range
It is that different sample rates is arranged in different channels under the control of logic control circuit.When the selection of multiplexer channel selection circuit is a certain
When paths, the sample rate of analog to digital conversion circuit will be automatically transitioned to the sample rate being arranged for selected channel；This design can be applied
Yu Dangben platform chip integrates multiple biosensors, and in different input channels to the sample rate of different biological samples
Requirement have the case where bigger difference.
Preferably, the digital signal being converted into step e is temporarily stored by storage inside circuit；This design can
So that multiplexer channel selection circuit and analog to digital conversion circuit are sampled with faster rate, but chip can be sent out with lower data transfer rate
Transmit data to external equipment.
Preferably, wireless receiver circuit will be according to the compatible different transmission frequencies of application and agreement in step f: making
It can be using medical treatment implantation Communications service frequency range (Medical Implant Communication for implantable products
Service Band, MICS) or inductive coupling mode (Inductive Coupling) set with the outside of same protocol is taken
Standby docking；As non-built-in mode product, IEEE802.11 agreement or Bluetooth technology and external smart equipment can be taken directly logical
News.
Preferably, in step f external equipment except have data analyze in real time, show and warning function in addition to, can also lead to
Cross data storage elements to data carry out external storage, to call historical data to be tracked, trend analysis research etc..
The present invention is passed by providing the design of the biosensor platform chip of a unified standard for various miniature organisms
Sensor provides unified a platform and interface, avoids the independent special designing manufacture that biosensor product is complicated, realizes
Simply and effectively integrate.Biosensor platform chip of the invention used bio-compatibility after both having can integrate single sensor
Encapsulation, safely implanted, effectively worked using wireless power and the communication technology；It is being printed after can also being packaged
Multiple sensors are integrated on circuit board, are formed in " miniature laboratory ", and utilize common wireless technical communication.In two ways,
Wireless data can be stored by external smart equipment, analyzed and be called.
Detailed description of the invention
Fig. 1 is the present invention as implantable products and uses schematic diagram.
Fig. 2 is the present invention as non-built-in mode product and uses schematic diagram.
Fig. 3 is the schematic diagram of the specific framework of biosensor platform chip of the present invention.
Specific embodiment
Below by conjunction with attached drawing, the present invention is further described.
Embodiment: the present invention is as shown in Figure 1 as the embodiment that implantable products use.
It is implanted into body portion and 12, inductive coupling is encapsulated by biosensor platform chip 10, biosensor 11, bio-compatible
Coil 13 and antenna 14 form.Wherein biosensor platform chip 10 is to be inverted chip bonding (Flip Chip Bonding)
Mode is connect with biosensor 11.The generated micro- electricity of multichannel after the sensing device contact biological sample of biosensor 11
Signal by biosensor platform chip 10 acquisition amplification after by a series of digitized signal treatment processes 150, in an orderly manner
It generates data packet (referred to as forward data), is sent out by antenna 14 using medical treatment implantation Communications service frequency range 121 after then modulated
It send.(Load can also be modulated using load by inductance-coupled coil 13 in another kind design ventrocephalad data
Modulation technology) is sent.
The basic composition of special external equipment 22 includes data transmit-receive and power drives device 20, data storage controller part
21, data analysis processor part 25, display alarm part 26, inductance-coupled coil 23 and antenna 24.Inductance-coupled coil 23 will
Electric energy 120 passes to inductance-coupled coil 13 on implant by way of inductive coupling, to be entire biosensor
Platform chip 10 is powered.Antenna 24 is communicated using medical treatment implantation Communications service frequency range 121 and implantation body antenna 14, and antenna 24 receives
To data stored in data storage controller part 21 after data transmit-receive and power drives device 20 demodulate.Data analysis
Processing apparatus 25 calls the related data stored in data storage controller part 21 to be calculated, analysis is handled, and correlated results is logical
Display alarm part 26 is crossed to be shown and alarmed.Under another kind design, data communication can also pass through the side of inductive coupling
Formula 120 is completed.Forward data caused by biosensor platform chip can change inductance coupling using load modulation technique
The load of zygonema circle 13 passes to special external equipment 22 by the induction of inductance-coupled coil 23.
It should be noted that using inductance-coupled coil still using antenna either to carry out data communication, data-link
Road is all two-way.Special external equipment can generate different order and configuration information by storage control part 21, and next pair
The biosensor platform chip for being implanted into body portion carries out some operation controls.These orders and configuration information are referred to as reversed number
According to.Reverse data can also equally be set by antenna 24 and 14 using medical treatment implantation Communications service frequency range 121 in another kind
Modulated is counted in power driving signal, by inductance-coupled coil 23 and 13,120 transmitting by the way of inductive coupling.
Embodiment: the present invention is as shown in Figure 2 as the embodiment that non-built-in mode product uses.
Biosensor platform chip 10 after being packaged 50 on printed circuit board 28 with multiple biosensor collection
At forming one has " the miniature laboratory " for examining a variety of biological sample abilities.Number 60,61 to 70,71, number 80,81
Different types of multiple biosensors are indicated to 90,91, and actual quantity is unrelated with number, but is determined by concrete application
It is fixed, the maximum quantity number of independent multichannel input interface and each biology as provided by biosensor platform chip 10
The number of the output channel (interface) of sensor determines.Biosensor platform chip 10 acquires the biological sample in each channel,
Generate data packet (referred to as forward data) in an orderly manner, it is then modulated after by antenna 14 using IEEE802.11 wireless protocols or
Bluetooth technology 122 is sent.Under such use pattern, the power supply of entire printed circuit board is by battery 51 or external dc power
Power supply.
External smart equipment 103 (computer, smart phone, palm PC etc.) can be used by its antenna 102
IEEE802.11 wireless protocols or the antenna of Bluetooth technology and biosensor platform chip 14 communicate, and received data exist
Storage in data storage controller part 100 inside smart machine.Under the control of relative application software (Applications),
Data operation processing apparatus 101 calls the related data stored in data storage controller part 100 to be calculated, analysis is handled,
Show correlated results and alarm.Equally, external smart equipment 103 can produce different order and configuration information, to biology
Sensor platform chip 10 carries out some operation controls.These orders and configuration information are referred to as reverse data.Reverse data is same
Sample is transmitted by antenna 102 and 14 using IEEE802.11 wireless protocols or Bluetooth technology.Therefore data link is two-way.
Embodiment: the specific structure is shown in FIG. 3 for biosensor platform chip 10 of the present invention.
The power supply of chip entire first may come from inductance-coupled coil 13 when using as implantable products and pass through
The mode of inductive coupling receives the wireless power source driving signal of external equipment transmission, and passes through 18 shaping filter of wireless power circuit
For DC voltage.Simultaneously wireless power circuit 18 can also from wireless power source driving signal recovered clock signal, as entire core
The fundamental clock signal of piece supplies logic control circuit 19.As non-built-in mode product in use, chip of the present invention does not need
It is powered, can directly be powered by external dc power or battery 51, at this time the system-based clock of chip using wireless power source
Signal is supplied by external crystal oscillator 56.Micro- electricity caused by the single or multiple biosensors that chip of the present invention integrates
Signal passes through independent multichannel input interface 130 to 141 first.Low noise pre-amplification circuit 30 to 41 is by the micro- of each paths
Electric signal is amplified to " amplified signal " being preferably proportional to.Here number 130 to 141,30 to 41 is used merely as illustrating
Purposes indicates used multiple channels, does not represent the actual quantity in used channel.These " amplified signals " are through excessive
Paths selection circuit 52 successively selects wherein one with frequency (duration) in certain sequence under the control of logic control circuit 19
Road signal is input to analog to digital conversion circuit 53.For different application, multiplexer channel selection circuit 52 is in logic control circuit 19
The channel that lower of control is used required for selecting, the channel being not used is not selected.Analog to digital conversion circuit 53 is pressed
Analog-to-digital conversion is carried out according to " amplified signal " of the sample rate provided by logic control circuit 19 to selected channel, is transformed into
It is stored in internal storage circuit 54 after digital signal.Analog to digital conversion circuit 53 is had the ability for different channels by logic control
Different sample rates is arranged in circuit.Data in storage inside circuit 54 are packaged with certain timing by logic control circuit 19 again
And it reads in forward data transmitting line 16 and is modulated.Forward data can be sent by antenna 14, can also be another
Pass through inductance-coupled coil 13 using load modulation technique 58 under kind design to send.Chip of the present invention may also receive from simultaneously
Order, configuration information or confirmation signal of external equipment etc., referred to as reverse data.Reverse data can be received by antenna 14,
Selection circuit 17 determines forward data transmitting line 16 under the control of logic control circuit 19 according to relevant communications protocol
Circuit 15 is received to the control of antenna 14 with reverse data.Order or configuration information receive circuit 15 by reverse data and demodulate
It afterwards and is transmitted to logic control circuit 19 and carries out some extremely flexible operations and control, for example change multiplexer channel selection circuit
The selection setting in 52 pairs of channels, the setting of selecting sequence and frequency (duration) have the ability to select any choosing with arbitrary duration
Fixed channel；For example change the setting of the sample rate of analog to digital conversion circuit 53, identical or different adopt is arranged to different channels
Sample rate etc..Under another kind design, the reverse data of external equipment is modulated at the transmission of wireless power source driving signal, at this time instead
It can be received to data by inductance-coupled coil 13, send reverse data to after range of decrease processing 57 and receive circuit 15 to solve
It adjusts.
Claims (22)
1. a kind of biosensor platform chip, it is characterised in that: including independent multichannel input interface, the preposition amplification electricity of low noise
Road (Low-Noise-Preamplifier), multiplexer channel selection circuit (Multiplexer), analog to digital conversion circuit (Analog
To Digital Converter, ADC), logic control circuit (Digital Controller), storage inside circuit
(Memory), wireless receiver circuit (Wireless Transceiver), wireless power circuit (Wireless Power
Recovery)；This platform chip by foregoing circuit module by way of large scale integrated circuit integrate on one chip, from
And a unified platform and interface, the output channel of the biosensor are provided for various types of biosensor
It is attached with the independent multichannel input interface of this platform chip, is generated by low noise pre-amplification circuit and adopted with each channel
Micro- electric signal of collection proportional " amplified signal " selects " the amplification letter of each paths by multiplexer channel selection circuit
Number ", analog to digital conversion circuit is passed it to, it will by sample rate provided by analog to digital conversion circuit logically control circuit
" amplified signal " is converted into digital signal and is stored in storage inside circuit, and the digital signal in storage inside circuit is passed through core
The logic control circuit and wireless receiver circuit that piece provides are sent to external equipment in an orderly manner and are analyzed and shown, and
Store the data storage of external equipment.
2. biosensor platform chip according to claim 1, it is characterised in that: partly led using complementary metal oxide
The manufacture of body (Complementary Metal Oxide Semiconductors) Technology design.
3. biosensor platform chip according to claim 1, it is characterised in that: the independent multichannel input interface
Possess the independent input channel that quantity is greater than 100, can be used for acquiring different biological samples, or the sample of acquisition different zones.
4. biosensor platform chip according to claim 1, it is characterised in that: the multiplexer channel selection circuit exists
Under the control of the logic control circuit, the required channel used can be only selected for different applications；That is this platform chip
The high density channel possessed can might not all be used, and will have the channel quilt of different number in different applications
It is idle；Chip to the selection in channel is configured by the order and configuration information of reception external equipment.
5. biosensor platform chip according to claim 1, it is characterised in that: analog-digital conversion circuit as described is according to institute
It states timing provided by logic control circuit and the sample of multiple acquisition channels is converted to digital signal in an orderly manner by order；This mould
Number conversion circuit should have larger dynamic input range to meet the specification demands of different sensors.
6. biosensor platform chip according to claim 1 or 5, it is characterised in that: analog-digital conversion circuit as described
Sample rate has reasonable biggish dynamic select range, and it is that different channels is arranged that configuration information can be sent by external command
Different sample rates.
7. biosensor platform chip according to claim 1, it is characterised in that: the logic control circuit is responsible for more
Selection and timing control of the paths selection circuit to channel；It is responsible for the setting of analog to digital conversion circuit sample frequency；It is responsible for from interior
The reading of data and packing are handled in portion's memory；It is responsible for the communication with wireless receiver circuit；Logic control circuit
It, can also be by sending order to any in addition to the sample of successively collecting used input channel orderly by normal mode
Input channel carries out the switch control of any duration.
8. biosensor platform chip according to claim 1, it is characterised in that: the storage inside circuit will be each
The digital signal that channel is converted to temporarily is stored；This design can make multiplexer channel selection circuit and analog to digital conversion circuit
It is sampled with faster rate, but chip can send data to external equipment with lower data transfer rate.
9. biosensor platform chip according to claim 1, it is characterised in that: the wireless receiver circuit
Will be as needed, use different transmission frequencies and agreement: can be using medical treatment implantation Communications service frequency range as implantable products
(Medical Implant Communication Service Band, MICS) or inductive coupling mode (Inductive
Coupling it) is docked with the external equipment of same protocol is taken；As non-built-in mode product, IEEE 802.11 can be taken to assist
View or Bluetooth technology and external smart equipment Direct Communication.
10. biosensor platform chip according to claim 1, it is characterised in that: the wireless power circuit, it can be with
Wireless power is carried out to entire chip using coil coupled modes, to use in integrated implantable products, operation is avoided to plant
Enter battery and electric wire；Meanwhile this circuit also provides DC power supply and directly inputs interface；As non-built-in mode product in use,
Direct battery or DC power supply can be taken to power.
11. a kind of integrated working method of biosensor platform chip, including 1 to 10 described in any item biosensors
Platform chip, it is characterised in that: the following steps are included:
A, single or multiple biosensors are integrated in this platform chip, i.e., by the output channel of biosensor and this platform
The independent multichannel input interface of chip is attached；
B, the sensor integrated, by the sensor sensing device contacted with bioactive materials, to acquire bioactivity material
Electrochemical signals caused by expecting, visible light signal, magnetic signal or thermal signal etc., and micro- telecommunications is converted by these signals
Number；
C, the low noise pre-amplification circuit provided by chip is proportional to each channel micro- electric signal collected to generate
" amplified signal "；
D, " putting for each paths is selected according to certain timing by the multiplexer channel selection circuit that chip provides in an orderly manner
Big signal ", passes it to analog to digital conversion circuit；
E, " amplified signal " is converted by digital letter by sample rate provided by analog to digital conversion circuit logically control circuit
Number and be stored in internal storage；
F, the logic control circuit and wireless receiver circuit provided the digital signal in memory by chip is orderly
Ground is sent to external equipment and is analyzed and shown, and stores the data storage for arriving external equipment.
12. the integrated working method of biosensor platform chip according to claim 11, it is characterised in that: step
External equipment in f are as follows: the smart machines such as computer or smart phone or palm PC.
13. the integrated working method of biosensor platform chip according to claim 11, it is characterised in that: step
The quantity of independent multichannel input interface in a should have the requirement that quantity is higher than 100；For different application, basis is only needed
The number of interface used in it selects the input interface of respective numbers, and changes corresponding interface panel (pad) as needed
In the location layout of chip surface metal layer；The quantity of input interface and the programmable outside that passes through of specific channel selecting are ordered
Enable setting.
14. the integrated working method of biosensor platform chip described in any one of 1-13 according to claim 1,
Be characterized in that: in step a, single biosensor and the integrated of biosensor platform chip as implantable products are adopted
It is integrated with chip (flip-chip) binding technology is inverted；Independent multichannel used in biosensor platform chip is defeated at this time
The number of incoming interface and its position for being located at chip (are connect by the output channel of concrete application and institute's integral biosensor
Mouthful) number and relative position determine；Complete the encapsulation for taking closed bio-compatible after integrating again, it can had safely
Implant to effect.
15. the integrated working method of biosensor platform chip described in any one of 1-13 according to claim 1,
It is characterized in that: in step a, as multiple biosensors of non-built-in mode product and integrating for biosensor platform chip
It is integrated using printed circuit board；Biosensor platform chip can be first packaged to be advantageously integrated at this time；Biology passes at this time
The number of independent multichannel input interface used in sensor platform chip is by the number of institute's integral biosensor and its is defeated
The number of channel (interface) determines out.
16. the integrated working method of biosensor platform chip according to claim 11, it is characterised in that: step
There is low noise, low-power consumption, high cmrr (CMRR), high PSRR per low noise pre-amplification circuit all the way in c
(PSRR), performance changes the characteristics such as small with flow-route and temperature.
17. the integrated working method of biosensor platform chip according to claim 11, it is characterised in that: step
Logically the pre-set sequence of control circuit and frequency select " putting for channel all the way for multiplexer channel selection circuit in d
Big signal " simultaneously inputs to analog to digital conversion circuit；Multiplexer channel selection circuit is under the control of logic control circuit for different
Using the channel used required for only selecting；The sequence and frequency of this access selection can be outer by receiving by logic control circuit
The order of portion's equipment and configuration information are arranged to change.
18. the integrated working method of biosensor platform chip according to claim 11, it is characterised in that: step
Logically the pre-set sample rate of control circuit carries out " amplified signal " in selected channel to analog to digital conversion circuit in e
It samples and is converted to digital signal；The sample rate of usual analog to digital conversion circuit should be than the frequency of multiplexer channel selection circuit selector channel
Rate is much higher, so that every paths collect enough sample points；Sample rate can be external by receiving by logic control circuit
The order of equipment and configuration information are arranged to change.
19. the integrated working method of biosensor platform chip described in 1 or 18 according to claim 1, it is characterised in that:
The sample rate of analog to digital conversion circuit in step e has reasonable biggish dynamic select range, can be in logic control circuit
Control is lower to be arranged different sample rates for different channels；When multiplexer channel selection circuit selects a certain paths, modulus turns
The sample rate for changing circuit will be automatically transitioned to the sample rate being arranged for selected channel；This design can be applied to when this platform chip collection
There is bigger difference at multiple biosensors, and in requirement of the different input channels to the sample rate of different biological samples
The case where.
20. the integrated working method of biosensor platform chip according to claim 11, it is characterised in that: step
The digital signal being converted into e is temporarily stored by storage inside circuit；This design can make multiplexer channel selection circuit
It is sampled with faster rate with analog to digital conversion circuit, but chip can send data to external equipment with lower data transfer rate.
21. the integrated working method of biosensor platform chip according to claim 11, it is characterised in that: step
Wireless receiver circuit will be according to the compatible different transmission frequencies of application and agreement in f: can use as implantable products
Medical treatment implantation Communications service frequency range (Medical Implant Communication Service Band, MICS) or inductance
Coupled modes (Inductive Coupling) are docked with the external equipment of same protocol is taken；It, can as non-built-in mode product
To take IEEE802.11 agreement or Bluetooth technology and external smart equipment Direct Communication.
22. the integrated working method of biosensor platform chip according to claim 11, it is characterised in that: step
In f external equipment except have data analyze in real time, show and warning function in addition to, can also by data storage elements to data into
Row external storage, to call historical data to be tracked, trend analysis research.
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| WO2016068295A1 (en) * | 2014-10-30 | 2016-05-06 | 富士フイルム株式会社 | Sensor device, sensor system |
| DE102015001998B3 (en) * | 2015-02-20 | 2016-02-04 | Friz Biochem Gesellschaft Für Bioanalytik Mbh | Microfluidic cartridge for the detection of biomolecules |
| US9706269B2 (en) * | 2015-07-24 | 2017-07-11 | Hong Kong Applied Science and Technology Research Institute Company, Limited | Self-powered and battery-assisted CMOS wireless bio-sensing IC platform |
| CN109567796A (en) * | 2018-12-20 | 2019-04-05 | 南京畅享医疗科技有限公司 | A kind of superminiature radio physiological signal collection processing system |
| CN114371638A (en) * | 2020-10-15 | 2022-04-19 | 北京航天耐特科技有限公司 | Integrated circuit for vital sign detection and processing |
| CN115049050B (en) * | 2022-08-11 | 2022-11-22 | 北京冠邦开源智能系统工程技术有限公司 | Artificial intelligence oriented neural unit implementation method and circuit |
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