CN103690660A - Traditional Chinese medicine composition for stopping alopecia and regenerating hair and preparation method thereof - Google Patents
Traditional Chinese medicine composition for stopping alopecia and regenerating hair and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for stopping alopecia and regenerating hair and a preparation method thereof. The traditional Chinese medicine composition for stopping alopecia disclosed by the invention is prepared from the following raw materials in parts by weight: ficus aerial root, willow hair, eclipta, cacumen biotae and fructus psoraleae. The traditional Chinese medicine composition disclosed by the invention has the obvious therapeutic effect to alopecia areata and alopecia seborrhoeica; furthermore, the traditional Chinese medicine composition is simple for preparation, convenient for use, rapid in effect and free from side effects and is capable of removing acomia worry for hair loss people.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to Chinese medicine composition of a kind of hair growth accelerating and preparation method thereof.
Background technology
Alopecia be one of Modern human populations compared with universal phenomenon, perplexing many young and promising personages.Because alopecia one affects personal image, two have affected inter personal contact, and more serious also can affect the psychology of hair loss patient.
The reason of alopecia has: nerve, cryptorrhea, trophism, physical property, chemical, infectivity, symptomatic, congenital, seasonal alopecia etc.The alopecia areata that wherein cryptorrheic seborrheic alopecia and natural immunity cause is comparatively common.
Seborrheic alopecia claimed male pattern alopecia in the past, male pattern alopecia, and male alopecia, diffusivity alopecia, universality alopecia etc., its sick and heredity, androgen, seborrhea are relevant.Symptom is that scalp portion fat secretion is too much, and hair has greasy feeling.Clinical manifestation, for excessive the overflowing of patient's scalp fat, causes the greasy humidity of scalp, adds that dust and scurf mix, and within several days, does not wash hair just very dirty, and gives an offensive smell, especially all the more so when temperature is high; Sometimes also with the scalp inflammation of scratching where it itches, be mainly because scalp is moist, numerous raw infection of antibacterial causes seborrheic dermatitis.
Seborrheic alopecia is called as " post tineatonsurans " or " alopecia of damaging by worms " due to damp and hot invasion and attack skin in the traditional Chinese medical science, make nutritional disorder, space between skin and muscles is not solid, venation block, and the biochemical unfavorable Rhizoma Imperatae that causes of essence and blood does not cause alopecia admittedly, dialectically be: damp-heat in the spleen and stomach (is had a liking for food usually, sweet fertilizer, hair cream is wet, and squama is greasy, hair epidemic disease is itched, alopecia); Blood-deficiency and wind-dry (hair is dry, sparse coming off, and squama stacks, porrigo is itched).
Alopecia areata is a kind of non-cicatricial alopecia of autoimmunity, often betides the crinite position of health, and local skin is normal, no conscious sympton.Etiology unknown.At hair follicle, around have lymphocytic infiltration, and primary disease merges other autoimmune diseasees (as vitiligo, atopic dermatitis) sometimes, therefore think that at present the generation of primary disease may exist autoimmune pathogenesis.Heredodiathesis is also a key factor, may be relevant to HLA II type, and 25% case has family history.In addition, also may be relevant with traumatic nerve injury, psychological problem, infection focus and endocrine disturbance.
Alopecia areata can betide any age, but common with person between twenty and fifty, both sexes sickness rate no significant difference.Skin lesion shows as circle or the non-cicatricial alopecia of oval, at alopecia areata edge Chang Kejian " exclamation mark " sample hair.Hair comes off all or almost all, is called alopecia totalis.The all hairs (comprising chaeta) of whole body all come off, and are called general de-.Be also shown in the row alopecia of crawling.Lesion skin, except without hair, does not exist other abnormal.
The western medicine therapy of seborrheic alopecia is mainly by oral supplementation nutrition at present, or is coated with antiinflammatory outward:
(1) take each 10 milligrams of vitamin B2, every day 3 times; Each 20 milligrams of vitamin B6, every day 3 times; Or each 3 of compound vitamin B, every day 3 times.
(2) oral cystine is each 50 milligrams, every day 3 times;
(3) acute popularity pathological changes person, can take each 10 milligrams of prednisone, every day 3 times, or each 1.5 milligrams of dexamethasone, every day 3 times, is used in conjunction 5-7 days.
The traditional Chinese medical science also has the multiple treatment side that is used for the treatment of alopecia, but curative effect is all not too remarkable, or newborn hair is very soft, easily comes off again.For solving alopecia personage's worry, need to provide a kind of medicine of effective hair growth accelerating.
Summary of the invention
The Chinese medicine composition that the object of this invention is to provide a kind of hair growth accelerating;
Another object of the present invention is to provide a kind of preparation method of Chinese medicine composition of hair growth accelerating.
The object of the invention is to realize by following technical scheme:
The Chinese medicine composition of hair growth accelerating of the present invention is to be prepared from by the raw material that comprises following weight portion: Radix Aerio Fici Microcarpae 50-150 part, willow palpus 50-150 part, Herba Ecliptae 10-60 part, Cacumen Platycladi 10-60 part, Fructus Psoraleae 3-18 part.
The Chinese medicine composition of hair growth accelerating of the present invention, its preferred version is to be prepared from by the raw material that comprises following weight portion: Radix Aerio Fici Microcarpae 80-120 part, willow palpus 80-120 part, Herba Ecliptae 20-50 part, Cacumen Platycladi 20-50 part, Fructus Psoraleae 5-15 part.
The Chinese medicine composition of hair growth accelerating of the present invention, its further preferred version is to be prepared from by the raw material that comprises following weight portion: 100 parts of Radix Aerio Fici Microcarpae, 100 parts of willow palpuses, 30 parts of Herba Ecliptaes, 30 parts of Cacumen Platycladis, 10 parts of Fructus Psoraleaes.
The Chinese crude drug details adopting in the present invention is as follows:
Radix Aerio Fici Microcarpae: be the aerial root of moraceae plants Ficus microcarpa Linn. f.Can adopt the whole year.Cut off aerial root, be bundled into wisp, dry.Another name: hang (the standby > > that wants of the < < SHENGCAO property of medicine) half a day, hang wind root, Ficus microcarpa Linn. f palpus (< < gathers medicinal herbs in the south of the Five Ridges and records > >), Ficus microcarpa Linn. f hangs palpus (< < Guangdong Chinese medicine > >).Nature and flavor: bitterness, flat.Function cures mainly: expelling wind and clearing away heat, promoting blood circulation and detoxication.Control influenza, pertussis, measles without adequate eruption, tonsillitis, eye conjunctivitis, eruptive disease stomachache, rheumatic ostalgia, epistaxis, stranguria with blood, traumatic injury.
Willow palpus: be the root hair of Salicaceous Plants Salix babylonica L..Another name: water willow palpus (< < experiment of TCM research > >), red dragon palpus (< < Revision and Addition Tian Bao book on Chinese herbal medicine > >), divide water father-in-law (< < conventional glossary of Herbs and Drugs > > among the people), Green Dragon palpus (< < Traditional Chinese Medicine in Sichuan will > >).Nature and flavor: hardship, cold.Function cures mainly: diuretic, and treating stranguria, dispel the wind, dehumidifying.Control gonorrhea, nebulousurine, edema, jaundice, rheumatalgia, yellow fluid eczema, toothache, scalds.
Herba Ecliptae: be the herb of feverfew Eclipta prostrata, because while crumpling its stem and leaf, the juice of visible black color flows out, so cry again " tusche is careless ".Flavour of a drug: cold in nature.There is invigorating the liver and kidney, yin nourishing effect.Can hemostasis, growing and blacking hair, liver and kidney tonifying.
Cacumen Platycladi: the browse of Cupressaceae plant (Platycladus orientalis (L.) Franco).Medical material Cacumen Platycladi Duo You branch, little and different in size, be flakey.Color is bronzing.The visible leaf in surface is mutually to life, section yellow-white.Quality is crisp, easily fractureed.Feeble QI is fragrant, a kind of in the blood-cooling hemostatic of bitter and puckery flavor Chinese medicine hemorrhage, the effect that has hemostasis, black beard and hair, cough-relieving to breathe heavily.
Fructus Psoraleae: Arabic Psoralea pulse family (Psoralea bituminosa L.).Acrid in the mouth; Bitter; Warm in nature.Return kidney, pericardium, spleen, stomach, lung meridian.Function cures mainly: reinforcing the kidney and supporting YANG; Helping inspiration to relieve asthma; Warming spleen and stopping diarrha.Main insufficiency of kidney-YANG; Below element deficiency and cold; Chills and pain of the waist and kness; Impotence and seminal emission; Frequent micturition; The enuresis; Failure of the kidney in receiving QI; Dyspnea due to deficiency is more than; Asthenia of both the spleen and kidney; Stool chronic diarrhea; Outward for vitiligo; Speckle is bald; Psoriasis.
Another aspect of the present invention has been to provide the preparation method of active component of the present invention, and active ingredient of Chinese herbs of the present invention is to adopt the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from:
Scheme one: get whole raw medicinal materials, be ground into coarse powder, adding concentration expressed in percentage by volume is the soak with ethanol 20-60 days of 50-80%, ethanol consumption is crude drug gross weight 60-100 times, soak filters, and filtrate recycling ethanol is 40-60% to containing amount of alcohol, standing 20-30 days, filter, obtain described active component.
The scheme optimization of preparing of scheme one is:
Be ground into coarse powder, adding concentration expressed in percentage by volume is 60% soak with ethanol 30 days, and ethanol consumption is 80 times of crude drug gross weights, and soak filters, and filtrate recycling ethanol is to being 40% containing amount of alcohol, standing 30 days, filter, and obtain described active component.
Scheme two: get whole raw medicinal materials, be ground into coarse powder, use 40-80% alcohol reflux 2-3 time, doubly, extraction time is 2-4 hour to the 8-10 that each ethanol consumption is medical material total amount, and merge extractive liquid,, filters, and filtrate is condensed into fluid extract, obtains active component.
Scheme three: whole raw medicinal materials, be ground into coarse powder, extracting in water, water extraction liquid precipitate with ethanol, reclaims ethanol, and extracting solution merges distillate, mixes, and obtains active component.
The traditional Chinese medical science thinks that hair is main relevant to blood and kidney essense, hair is the sign of blood condition, essence of the kidney being reflected on the hair, and kidney qi declines, falling out, send out morning in vain.The source of nutrition of hair is in blood, and its growth power root, in kidney essense, has hair when body essence and blood is full only and just shows pitch-black tough.Otherwise work as deficiency of the liver and kindey, deficiency of qi and blood, essence is not changed blood, not hair care of blood, root of hair is hollow and come off, bleach, and hair jewelry, expensive clothing and other valuables are easily broken, and occur various aging phenomenons.And the inducement of seborrheic alopecia is the imbalance of internal body taste, damp and hot growing thickly just to show outside fat secretion excessive---face bellding light, scalp pomade is large, dandruff is many.
Radix Aerio Fici Microcarpae and willow palpus clearing heat and expelling damp in side of the present invention, fortune strengthening the spleen and stomach, controls fat secretion from source, scalp pomade dandruff is reduced, and scalp is salubrious, and hair follicle cell draws abundant nutrition smooth and easy breathing, thereby stops alopecia; After deliberation, the contained alligator weed lactone of Herba Ecliptae, nor-alligator weed lactone can effectively promote hair cell growth; Herba Ecliptae, Cacumen Platycladi, Fructus Psoraleae nourishing the liver and kidney, invigorating kidney-YANG, spleen reinforcing be empty, improve head blood microcirculation, thus guarantee internal body by abundant nutrient distribution to the crown, and be transported to smoothly hair follicle, hair follicle is nourished, naturally recovery life.We are by the first alopecia-stopping of clearing heat and expelling damp, nourishing the liver and kidney then, and hair growth promoting hair color, in side, each medicine matches suitablely, coordinates mutually, and seborrheic alopecia and alopecia areata are had to good curative effect.
The Chinese medicine composition of a kind of hair growth accelerating provided by the invention has the following advantages:
1, the present invention and positive drug group all cause ectillotic rat to have extremely significant anti-avulsion effect to injection testosterone propionate injection, and the clinical use of prompting the present invention is hair growth effectively.
2, the present invention and Western medicine group to the treatment situation of patient's alopecia have utmost point significant difference (
p< 0.01), clinical treatment effective percentage of the present invention is 91.7%, Western medicine group is 39.4%.Between the present invention 10 years, the patient of clinical treatment grows black coarse wool and sends out and follow up a case by regular visits to 2 years above 97 examples that have without recurrence,, show that the present invention has good hair growth accelerating effect, and be far superior to prior art.
3, therapeutic process of the present invention is not found allergy, the phenomenon such as abnormal, and clinical safety in utilization is high.
The specific embodiment
Below by embodiment, further illustrate the present invention.It should be understood that embodiments of the invention are for the present invention rather than limitation of the present invention are described.The simple modifications that essence according to the present invention is carried out the present invention all belongs to the scope of protection of present invention.Except as otherwise noted.
Embodiment 1
Get Radix Aerio Fici Microcarpae 100g, willow palpus 100g, Herba Ecliptae 30g, Cacumen Platycladi 30g, Fructus Psoraleae 10g.Be ground into coarse powder, adding concentration expressed in percentage by volume is 60% soak with ethanol 30 days, and ethanol consumption is 80 times of crude drug gross weights, and soak filters, and filtrate recycling ethanol is to being 40% containing amount of alcohol, standing 30 days, filter, and obtain described active component.
Embodiment 2
Get Radix Aerio Fici Microcarpae 50g, willow palpus 50g, Herba Ecliptae 10g, Cacumen Platycladi 10g, Fructus Psoraleae 2g.Be ground into coarse powder, adding concentration expressed in percentage by volume is 50% soak with ethanol 60 days, and ethanol consumption is 60 times of crude drug gross weights, and soak filters, and filtrate recycling ethanol is to being 40% containing amount of alcohol, standing 30 days, filter, and obtain described active component.
Embodiment 3
Get Radix Aerio Fici Microcarpae 150g, willow palpus 150g, Herba Ecliptae 60g, Cacumen Platycladi 60g, Fructus Psoraleae 18g.Be ground into coarse powder, adding concentration expressed in percentage by volume is 80% soak with ethanol 20 days, and ethanol consumption is 100 times of crude drug gross weights, and soak filters, and filtrate recycling ethanol is to being 60% containing amount of alcohol, standing 20 days, filter, and obtain described active component.
Embodiment 4
Get Radix Aerio Fici Microcarpae 80g, willow palpus 80g, Herba Ecliptae 20g, Cacumen Platycladi 20g, Fructus Psoraleae 5g.Be ground into coarse powder, with 40% alcohol reflux 2 times, each ethanol consumption is respectively 10 times, 8 times of medical material total amount, and each extraction time is respectively 4 hours, 2 hours, and merge extractive liquid, filters, and filtrate is condensed into fluid extract, obtains active component.
Embodiment 5
Get Radix Aerio Fici Microcarpae 120g, willow palpus 120g, Herba Ecliptae 50g, Cacumen Platycladi 50g, Fructus Psoraleae 15g.Be ground into coarse powder, extracting in water 3 times, three amount of water are equivalent to respectively 12 times, 8 times, 6 times of medical material gross weight, each extraction time is 3 hours, 2 hours, 1 hour, and merge extractive liquid, filters, the clear paste that when filtrate is concentrated into 70 ℃, relative density is 1.10, the ethanol that the percent by volume that adds 3 times of clear paste weight is 95%, stirs evenly, standing 24 hours, filter, filtrate is recycled to ethanol, filters, filtrate is condensed into fluid extract, obtains active component.
Embodiment 6
Get Radix Aerio Fici Microcarpae 80g, willow palpus 80g, Herba Ecliptae 20g, Cacumen Platycladi 20g, Fructus Psoraleae 5g.Be ground into coarse powder, with 80% alcohol reflux 3 times, each ethanol consumption is respectively 10 times, 8 times, 8 times of medical material total amount, each extraction time is respectively 3 hours, 2 hours, 2 hours, and merge extractive liquid, filters, filtrate is condensed into fluid extract, obtains active component.
Embodiment 7
Get Radix Aerio Fici Microcarpae 100g, willow palpus 120g, Herba Ecliptae 30g, Cacumen Platycladi 20g, Fructus Psoraleae 18g, above 5 tastes, clean rear dry, pulverizing, cross 80-100 mesh sieve, obtain powder of the present invention.
alopecia effect experiment
1, experiment material
(1) animal
Wistar rat, male and female half and half, body weight 200 ± 20g, buys from Guangxi Medical University's Experimental Animal Center (production licence number: SCXK osmanthus 2009-0002).
(2) medicine and reagent
Embodiment of the present invention 1-5, normal saline, 3% picric acid solution, testosterone propionate injection, Spironolactone Tablets.
2, experiment grouping
Wistar rat is divided into 8 groups at random: embodiment 1-5 group, blank group, model control group, positive drug group, 10 every group, male and female half and half, totally 80.
3, experimental technique
(1) modeling and administration
Each organizes the hair that rat is all chosen back 9cm * 7cm area, and the picric acid solution stained yellow with 3% is to determine depilation district.
Blank group: every day, gavage gave equal-volume normal saline, and after neck subcutaneous injection equal-volume normal saline, 1 times/day;
Model control group: every day, gavage gave equal-volume normal saline, and after neck subcutaneous injection testosterone propionate injection 5mg/ (kgd), 1 times/day;
Positive drug group: every day, gavage gave spironolactone suspension 9mg/kg, and after neck subcutaneous injection testosterone propionate injection 5mg/ (kgd), 1 times/day;
Embodiment 1-3 group: give respectively embodiment 1-3 medicine every day and be coated with outward, and after neck subcutaneous injection testosterone propionate injection 5mg/ (kgd), 1 times/day.
Embodiment 4-5 group: every day, gavage gave embodiment 4-5 medicine respectively, and after neck subcutaneous injection testosterone propionate injection 5mg/ (kgd), 1 times/day.
(2) index observing
In modeling and administration, after 4 weeks, the upper metabolic cage of rat is raised separately, observe rat dyed hair come off situation record every day, comprise yellow alopecia quantity and the dyeing district's alopecia situation of dying.Dyeing district's alopecia situation is carried out to integral estimation by table 1.
Table 1 rat depilation situation integration standard
4, experimental result
Each pharmaceutical intervention of table 2 on Hair of Rats come off quantity impact (n=10,
± s)
Note: with the comparison of blank group, * P < 0.05, * * P < 0.01; With model control group comparison,
▲ ▲p < 0.01.
Each pharmaceutical intervention of table 3 on the impact of rat depilation district depilation situation (n=10,
± s)
Note: with the comparison of blank group, * * P < 0.01; With model control group comparison,
▲ ▲p < 0.01.
Conclusion: the present invention and positive drug group all cause ectillotic rat to have extremely significant anti-avulsion effect to injection testosterone propionate injection, and the clinical use of prompting the present invention is hair growth effectively.
clinical trial
The curative effect of the anti-alopecia of the present invention is carried out to clinical observation, by contrast take medicine the alopecia situation of Patients Before And After, the effect of alopecia areata areal analysis hair growth accelerating of the present invention.
1 diagnosis basis
1.1 age of onset:
While being 1. born or infantile period generation alopecia person, mostly be heritability or congenital factor causes.If grow again after alopecia, can be physiological;
2. childhood period, play patient, common tinea capitis, trichotillomania etc.;
3. teenager and adolescence are sent out patient, and common mechanicalness alopecia, alopecia areata, bifurcated are sent out, cast hair, hair erosion, pinniform or trichoclasia etc.;
4. the woman in lactation period person of appearance, mostly is puerperal alopecia, and also there is similar alopecia climacteric; 5. middle-aged and elderly people is sent out patient, common hair dyeing dermatitis, seborrheic alopecia etc.
1.2 onset processes:
1. sudden onset person mostly is alopecia areata, trichotillomania etc.;
2. slowly play that patient is common male pattern alopecia, a senile alopecia etc.;
3. some patients first have other physical disease, and alopecia or alopecia are one of symptom of these diseases, or these diseases telogen effluvim of sudden fast rush after being ill;
4. contact antitumor drug or some as containing chemical agents such as thallium, lead, easily occurred growing period alopecia.
5. patient's hair is originally normal, and scalp occurs after some disease, and the hair coming off is always not long, may belong to cicatricial alopecia.
1.3 bald (taking off) are sent out scope:
1. alopecia generalisata be more common in that puerperal alopecia, abnormal thyroid function, hypopituitarism, lupus are sent out, sjogren syndrome, anemia, hepatopathy, malnutrition etc., and febrile disease as ileotyphus, pneumonia, meningitis, influenza etc. after being ill.
2. the alopecia of forehead both sides temples portion, head, mostly is hair style alopecia or male pattern alopecia.
3. occipitalia alopecia belongs to physical property alopecia more, is mainly to be caused by the local and coarse curtain frottages such as medicated pillow of scalp.
4. the alopecia at women's scalp edge, belongs to hair style alopecia or traction alopecia more, and hair follicle occurs that inflammation is comparatively common.
5. hair speckle flaking, can be thought of as alopecia areata, trichotillomania.
6. alopecia totalis or alopecia universalis should be specifically noted that the probability of congenital alopecia, alopecia areata.
1.4 alopecia quantity:
1. the hair number coming off every day is less than 100, and majority belongs to physiologic alopecia.
2. a large amount of alopecias in the short time, form acute, multiple alopecia areata, and even alopecia totalis, mostly is growing period alopecia;
3. still morbidity in 1-6 months after birth, hair all comes off and no longer grows, and should consider congenital total alopecia or some heredopathia syndromes;
4. generally progress is comparatively slow for telogen effluvim, and the hair coming off is no more than 50%.
1.5 hair forms:
1. many trichopathies have special hair form, as bifurcated is sent out, cystose is sent out, monilethrix, cast hair, hair erosion, hair subulate fracture, pinniform trichorrhexis, trichoclasia, trichorrhexis invaginata, trichothiodystrophy etc.
2. the growing period alopecia disease such as alopecia areata, the hair near-end ball top atrophy that it comes off attenuate be exclamation mark (! ) sample.
3. telogen effluvim disease, the hair near-end that it comes off is bar-shaped or pestle shape.Observe hair form major part and can recognize with magnifier also have part need to use optical microscope, ultramicroscope just can be made a definite diagnosis even.
2 auxiliary examinations
2.1 Endocrinological inspections: check estrogen level, thyroid function etc.
2.2 other: the disease examinations such as Analysis of Nutritive Status, systemic lupus erythematosus (sle), acquired immune deficiency syndrome (AIDS), syphilis.
3 alopecia degree diagnostic criterias:
3.1 alopecia area scorings: 0 is divided into without alopecia alopecia phenomenon (recovering > 80%); 1 is divided into alopecia area <6cm2(recovers > 60%); 2 are divided into alopecia area 6-15cm
2(recovering > 30%); 3 are divided into alopecia area >15cm
2(recovering < 30%).
3.2 hair growth promoting situations scorings: 0 is divided into and substantially there is no new growth; 1 be divided into grow less new; 2 are divided into and grow the new hair of part; 3 are divided into and grow more new hair, before treatment, have larger improvement.
2 case selections
20～60 years old age, be ready to accept 8 weeks therapists, signature enters clinical research Informed Consent Form person.
3 medicines
Experimental group: embodiment 1
Matched group: cystine
4 curative effect determinate standards
Basic healing: hair recovers area > 80%, alopecia phenomenon disappears, and hair is obviously grown;
Effective: hair recovers area > 60%, and alopecia phenomenon obviously disappears, hair starts growth;
Take a turn for the better: hair recovers area > 30%, and alopecia phenomenon disappears substantially, and hair is slowly grown;
Invalid: hair recovers area < 30%, and alopecia phenomenon still exists.
5 clinical grouping and Therapeutic Method
Enter to organize the routine patient of case 386, male 266 examples, female's 120 examples; Average approximately 39 years old; All patients all fill in self-questionnaire survey, and are diagnosed as hair loss patient through inspections such as head hair features, and get rid of the alopecia causing because of diseases such as systemic lupus erythematosus (sle), acquired immune deficiency syndrome (AIDS) and syphilis.Case is divided into two groups at random, and experimenter is carried out to double-blind, own control research before and after treatment.
Therapeutic Method:
Experimental group: the embodiment of the present invention 1, the skin place of painting alopecia, every day 3-4 time.
Matched group: each 50 milligrams of oral cystine, every day 3 times.
6 results
In experimental example group case, most of patient takes after the embodiment of the present invention 1, and alopecia phenomenon reduces or disappears, and before randomized controlled treatment, alopecia situation is found on inspection, and after treatment, hair growth is good.
Table 4: alopeciaing therapeutic effect
| Group | Number of cases | Be almost recovered | Effective | Take a turn for the better | Invalid | Total effective rate (%) |
| Experimental group | 193 | 97 | 39 | 41 | 16 | 91.7* |
| Matched group | 193 | 22 | 51 | 44 | 76 | 39.4 |
Note: experimental group and matched group comparison, *
p< 0.01.
As seen from the above table, the present invention and Western medicine group to the treatment situation of patient's alopecia have utmost point significant difference (
p< 0.01).Between the present invention 10 years, the patient of clinical treatment grows black coarse wool and sends out and follow up a case by regular visits to 2 years above 97 examples that have without recurrence, and therapeutic process is not found allergy, the phenomenon such as abnormal, shows that the present invention has good hair growth accelerating effect.
Model case:
1, Wang, man, 40 years old.Alopecia 9 months, and a readme oxygen, check and see impractical micro-the swelling of its scalp light, hair is sparse denumerable, and residual silk one touches to fall, tired.Through suggestion, adopt the embodiment of the present invention 1 to treat.Medicine for external application 12 days, readme alopecia reduces, head pruritus gradually stops, and hair is obviously tough and tensile, not like before one touch de-; , 18 of about every days of readme alopecia (genus physiologic alopecia), there is not again head pruritus in medication 28 days, check see its scalp sparse grow new; With the present invention, after 6 weeks, this patient's hair significantly increases, and alopecia district has born new, and hair is pliable and tough; After treatment finishes, each symptom of this patient has recovered normal.
2, what certain, female, 46 years old.Alopecia 5 months, readme is susceptible to lose temper due to restlessness over the past half year, and alopecia is many, can reach hundred every day, checks and sees that its hair is sparse, and hair is sallow, touches.Through suggestion, adopt the embodiment of the present invention 2 to treat.Affected part of exterior coating 9 days,, alopecia reduces; Medication 21 days, patient's readme alopecia obviously reduces (40-60 root approximately comes off every day), checks that to see that its hair presents soft bright, withered like before treatment.With the present invention, after 6 weeks, this patient's hair is day by day in great numbers, and hair jade-like stone is bright; After treatment finishes, the abnormal obscission of this patient's hair disappears, and spirit is straightforward.
3, bright, male, 42 years old, head alopecia areata 3 positions of old x, existing 2 years, once used ZHANGGUANG 101 regenerate clear 3 months invalid, also invalid with crossing Han Yong 9+9 4 months, with the outer painting of the embodiment of the present invention 3, within 7 days, just start afterwards to have grown fine, soft fur, within 20 days, become thick black wool, within 30 days, just overgrow with the dark hair of tubbiness.
4, land x pine, man 46 years old, head 1-5cm big or small alopecia areata 5 places such as not, used that ZHANGGUANG 101 regeneration is clear, 9+9 and many in brand is total with 3 invalid every year, by the embodiment of the present invention 4, treats, the normal dark hair that started long fine, soft fur, 40 days total lengths for 9 days.
5, Bears x its, man, 46 years old, to send out sparse glossy the alopecia of seborrhea surname, the crown once with cubic metre of earth, secret recipe treatment, invalid with ZHANGGUANG 101 treatment 4 months, after Korea Spro is invalid with 9+9 hair growth promoter 2 months, with the embodiment of the present invention 5 treatments, after 20 days, start to grow delicate hair.
Claims (8)
1. a Chinese medicine composition for hair growth accelerating, is characterized in that it is to be prepared from by the raw material that comprises following weight portion: Radix Aerio Fici Microcarpae 50-150 part, willow palpus 50-150 part, Herba Ecliptae 10-60 part, Cacumen Platycladi 10-60 part, Fructus Psoraleae 3-18 part.
2. the Chinese medicine composition of hair growth accelerating as claimed in claim 1, is characterized in that it is to be prepared from by the raw material that comprises following weight portion: Radix Aerio Fici Microcarpae 80-120 part, willow palpus 80-120 part, Herba Ecliptae 20-50 part, Cacumen Platycladi 20-50 part, Fructus Psoraleae 5-15 part.
3. the Chinese medicine composition of hair growth accelerating as claimed in claim 2, is characterized in that it is to be prepared from by the raw material that comprises following weight portion: 100 parts of Radix Aerio Fici Microcarpae, 100 parts of willow palpuses, 30 parts of Herba Ecliptaes, 30 parts of Cacumen Platycladis, 10 parts of Fructus Psoraleaes.
4. the Chinese medicine composition of the hair growth accelerating as described in one of claim 1-3, the active component that it is characterized in that it is to adopt the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume to be prepared from.
5. the Chinese medicine composition of hair growth accelerating as claimed in claim 4, is characterized in that its active component is prepared from by the following method:
Get whole raw medicinal materials, be ground into coarse powder, adding concentration expressed in percentage by volume is the soak with ethanol 20-60 days of 50-80%, ethanol consumption is crude drug gross weight 60-100 times, and soak filters, and filtrate recycling ethanol is 40-60% to containing amount of alcohol, standing 20-30 days, filters, and obtains described active component.
6. the Chinese medicine composition of hair growth accelerating as claimed in claim 5, is characterized in that its active component is prepared from by the following method:
Get whole raw medicinal materials, be ground into coarse powder, adding concentration expressed in percentage by volume is 60% soak with ethanol 30 days, ethanol consumption is 80 times of crude drug gross weights, and soak filters, and filtrate recycling ethanol is 40% to containing amount of alcohol, standing 30 days, filter, obtain described active component.
7. the Chinese medicine composition of hair growth accelerating as claimed in claim 4, is characterized in that its active component is prepared from by the following method:
Get whole raw medicinal materials, be ground into coarse powder, use 40-80% alcohol reflux 2-3 time, doubly, extraction time is 2-4 hour to the 8-10 that each ethanol consumption is medical material total amount, and merge extractive liquid,, filters, and filtrate is condensed into fluid extract, obtains active component.
8. the Chinese medicine composition of hair growth accelerating as claimed in claim 4, is characterized in that its active component is prepared from by the following method:
Get whole raw medicinal materials, be ground into coarse powder, extracting in water, water extraction liquid precipitate with ethanol, reclaims ethanol, and extracting solution merges distillate, mixes, and obtains active component.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104208187A (en) * | 2014-07-27 | 2014-12-17 | 杨通神 | Preparation method of hair-growing solution |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102727595A (en) * | 2012-07-04 | 2012-10-17 | 重庆港轶生物科技有限公司 | Chinese compound hair growth promoting composition and preparation method thereof |
| CN103202790A (en) * | 2013-05-03 | 2013-07-17 | 郭宏刚 | Purely natural shampoo |
| CN103223158A (en) * | 2013-05-21 | 2013-07-31 | 辛舒畅 | External medicine for treating alopecia |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102727595A (en) * | 2012-07-04 | 2012-10-17 | 重庆港轶生物科技有限公司 | Chinese compound hair growth promoting composition and preparation method thereof |
| CN103202790A (en) * | 2013-05-03 | 2013-07-17 | 郭宏刚 | Purely natural shampoo |
| CN103223158A (en) * | 2013-05-21 | 2013-07-31 | 辛舒畅 | External medicine for treating alopecia |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104208187A (en) * | 2014-07-27 | 2014-12-17 | 杨通神 | Preparation method of hair-growing solution |
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