CN103610454B - Blood pressure measurement method and system - Google Patents
Blood pressure measurement method and system Download PDFInfo
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- CN103610454B CN103610454B CN201310651502.6A CN201310651502A CN103610454B CN 103610454 B CN103610454 B CN 103610454B CN 201310651502 A CN201310651502 A CN 201310651502A CN 103610454 B CN103610454 B CN 103610454B
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Abstract
The invention discloses a blood pressure measurement method and system. The method comprises the following steps that a blood pressure measurement expression with correction factors is set according to the relationship between shear stress and the blood flow velocity V; characteristic parameters of the blood flow velocity V of a measured object are obtained, meanwhile the blood pressure reference value of the measured object is directly collected through a pressure gauge, and inverse calculation is conducted on the blood pressure measurement expression to obtain a correction factor value; when the practical blood pressure measurement is conducted, the correction factor value of the corresponding measured object is read from a database, and the blood pressure measuring result is calculated on the basis of the blood pressure measurement expression and the characteristic parameters, collected in real time, of the blood flow velocity. The blood pressure measurement method and system are simple, safe, convenient in test, and can achieve remote real-time monitoring of the blood pressure of the user, are good in real-time detection performance, can cope with various accidents of sudden illness of a blood-pressure-disease patient timely, eliminate the damage to the human body by a traditional direct measurement method, store the correction factors and characteristic constant values of the different measured objects for blood pressure calculation, and are high in measurement accuracy.
Description
Technical field
The present invention relates to a kind of blood pressure measuring method and system.
Background technology
Systemic arterial blood pressure is called for short blood pressure (blood pressure, BP).Blood pressure be blood when intravascular flow, make
For the pressure of blood vessel wall, it is to promote blood at the power of intravascular flow.Ventricular systole, blood flows into tremulous pulse from ventricle,
Now blood is the highest to the pressure of tremulous pulse, is referred to as shrinking pressure (systolic blood pressure, SBP).Ventricular diastole, dynamic
Arteries and veins blood vessel elasticity bounces back, and blood the most slowly continues flow forward, but blood pressure drops, pressure now is referred to as diastolic pressure
(diastolic blood pressure, DBP).
Along with increasing of Hypertension incidence, sphygomanometer has come into the life of people, becomes the family that a lot of people is indispensable
One of front yard apparatus, offers convenience for early discovery hypertension and monitoring therapeuticing effect.Measure blood pressure method have direct method and
Connection.The direct method of measurement is again invasive measurement method, namely by puncturing the blood pressure recorded after Ink vessel transfusing places conduit, such as
The invasive blood pressure of patient will be monitored when doing Cardiac interventional diagnosis and treatment.Blood pressure is directly measured, because being surveyed by invasive method
Position is different, and method is different, can not reflect the blood pressure of human body completely.The indirect method of measurement is again non-invasive measurement method, the most not
By puncturing after Ink vessel transfusing places conduit but by the blood pressure indirectly recorded.The indirect method of measurement is the side that people commonly use at ordinary times
Method, the main arteriotony measuring upper arm, operation conveniently, safely, is the side measuring blood pressure conventional in Hospitals at Present and family
Method, is divided into auscultation and oscillographic method.Auscultation is again Korotkoff's Sound method, is also classified into artificial Korotkoff's Sound method and electronics Korotkoff's Sound method.With
The blood pressure that auscultation records also can only be an approximation, and its levels of precision and measurement technology have certain relation.Oscillographic method is also named and shakes
Swing method, be a kind of more advanced electronic measuring method grown up the nineties.Such method of testing develops into nowadays develop
Product for various sphygomanometers.
Traditional blood pressure is in respect of electric sphygmomanometer, mercurial sphygmomanometer (piezometer), spring meter type blood pressure meter (piezometer).Electricity
Sub-blood pressure in respect of arm-type, wrist point；Its technology experienced by the first generation (the most original arm-type and wrist) of " having gaseous core ", " nothing
Gaseous core " the second filial generation (arm-type use) and the development of the third generation (wrist use).Mercurial sphygmomanometer (piezometer) and spring tabular form
Sphygomanometer (piezometer) measures blood pressure based on auscultation, it is necessary to coordinate stethoscope, doctor or nurse judge, draw contraction pressure,
The reading of diastolic pressure.Wherein, China will be completely forbidden in 2013 and use hydrargyrum, mercurial sphygmomanometer city to be gradually backed out
?.On market, existing spring sphygomanometer and electric sphygmomanometer are all to utilize inflating pressures such as cuff, air bag or tracheas, arrive
Certain pressure (general than shrink pressure exceed 30～50mmHg) stops pressurization afterwards, starts to exit, when air pressure to a certain extent, blood flow
Just can pass through blood vessel, and have certain wave of oscillation, the wave of oscillation travels to pressure transducer by trachea, and pressure sensing can be examined in real time
Measure the pressure in surveyed cuff and fluctuation.Gradually exitting, the wave of oscillation is increasing.Exit again contacting due to cuff and arm
The most loose, pressure and fluctuation that therefore pressure transducer is detected are more and more less.The moment selecting fluctuation maximum is reference point, with this
Based on Dian, searching is the fluctuation point of peak value 0.45 forward, and this point is for shrinking pressure, and searching is the fluctuation of peak value 0.75 backward
Point, the pressure corresponding to this point is diastolic pressure, and the highest pressure corresponding to point that fluctuates is mean pressure.This method of testing
The pressure value degree of accuracy recorded is higher, but blood vessel can cause extruding injury；And tested every time and carried out inflation/deflation, it is difficult to
Frequently measure or measure continuously；Inflation/deflation is that general recommendations is immovable, also requires that gauger keeps certain posture, as measured
The back of the hand or wrist then require that sphygomanometer and heart are maintained on sustained height horizontal line, therefore can not monitor the blood pressure of human body in real time
Situation.
Summary of the invention
In order to overcome the weak point of the prior art of above-mentioned indication, the present invention provides a kind of blood pressure measuring method and is
System, to realize monitoring safely, conveniently, accurately, in real time the blood pressure of user.
The present invention is achieved by the following technical solutions:
A kind of blood pressure measuring method, comprises the following steps:
S1, according to shearing stress τwAnd the relation between velocity of blood flow VRe is Reynolds number, and ρ is blood
Density, sets the expression formula of blood pressure measurement as shrinking pressureDiastolic pressure
AS、ADFor correction factor；
S2, the velocity of blood flow characteristic parameter of acquisition measurement object, utilize piezometer directly to gather this measurement object simultaneously
After blood pressure reference value the expression formula to blood pressure measurement are inversely calculated correction factor value, correction factor value is stored in
It is subordinated in the data base of this measurement object；
S3, when carrying out actual blood pressure and measuring, from data base, read the corresponding correction factor value measuring object, based on blood
The expression formula of pressure measurement and the velocity of blood flow calculation of characteristic parameters blood pressure measurement of Real-time Collection.
In step S1, described reynolds number Re uses experience constant, or utilizesCalculating gained, η is right for measuring
The blood viscosity coefficient of elephant, d is blood vessel diameter.
In step s 2, available light Power Capacity pulse tracing obtains the velocity of blood flow characteristic parameter measuring object, bag
Include:
S21, measure and record photoplethysmographic signal, the waveform obtained is obtained after AD conversion reflection blood stream
Real-time AD value Q of amountAD；
S22, the quadratic equation setting up velocity of blood flow V are QAD=α V2+ β V+ γ, α, β, γ are correction factor, determine blood
Flow velocity
In this embodiment, described step S21 uses bounce technique or transmission measurement photoplethysmographic signal.
Or, in step s 2, obtain measure object velocity of blood flow characteristic parameter be use ultrasonic Detection Method or
Laser detection method or pressure sensing detection method gather velocity of blood flow V.
In described step S2, directly gather measurement by electric sphygmomanometer or mercurial sphygmomanometer or spring meter type blood pressure meter right
The contraction pressure τ of elephantwSWith diastolic pressure τwD, recycling shrinks pressure τwSWith diastolic pressure τwDExpression formula be inversely calculated measurement
After the correction factor value of object, this correction factor value is stored in data base.
The present invention blood pressure measuring method also include: pre-build the data base measuring object, gather and measure object
Density of blood ρ, blood viscosity coefficient η, blood vessel diameter d are also stored in data base as feature constant.
The invention also discloses a kind of blood pressure measuring system, including:
Expression formula derivation module, for according to shearing stress τwAnd the relation between velocity of blood flow VRe
For Reynolds number, ρ is density of blood, sets the expression formula of blood pressure measurement as shrinking pressureDiastolic pressureAS、ADFor correction factor；
Data acquisition module, for obtaining the velocity of blood flow characteristic parameter measuring object, utilizes piezometer directly to adopt simultaneously
After collection is measured the blood pressure reference value of object and the expression formula of blood pressure measurement is inversely calculated correction factor value, will revise
Coefficient value is stored in the data base being subordinated to this measurement object；
Result computing module, for when carrying out actual blood pressure and measuring, reads repairing of corresponding measurement object from data base
Positive coefficient value, the velocity of blood flow calculation of characteristic parameters blood pressure measurement of expression formula based on blood pressure measurement and Real-time Collection.
It is to use photoplethysmographic to retouch that described data acquisition module obtains the velocity of blood flow characteristic parameter of measurement object
Any one in notation, ultrasonic Detection Method, laser detection method and pressure sensing detection method.
The blood pressure measuring system of the present invention also includes data base's creation module, for pre-building the data measuring object
Storehouse, gathers and measures the density of blood ρ of object, blood viscosity coefficient η, blood vessel diameter d and be stored in data base as feature constant
In.
Compared with prior art, the present invention have test simply, safely and conveniently feature, by using the light of portable
The monitoring devices such as Power Capacity pulse wave, ultrasound wave can realize the blood pressure of remote real time monitoring user；Owing to detection property in real time is strong, subtract
The various accidents of little blood pressure diseases patient's sudden illness；Eliminate the injury to human body of traditional direct measuring method simultaneously；Store difference
Measure the correction factor of object and feature constant calculates blood pressure, there is specific aim, certainty of measurement is high.
Accompanying drawing explanation
Accompanying drawing 1 be the blood pressure measuring method of an embodiment of the present invention realize schematic flow sheet；
Accompanying drawing 2 be the blood pressure measuring method of another kind embodiment of the present invention realize schematic flow sheet；
Accompanying drawing 3 is the principle schematic that in the present invention, ultrasonic Detection Method measures velocity of blood flow；
Accompanying drawing 4 is the composition schematic diagram of the blood pressure measuring system of an embodiment of the present invention；
Accompanying drawing 5 is the composition block diagram of the Intelligent worn device of the application present invention.
Detailed description of the invention
For the ease of the understanding of those skilled in the art, with embodiment, the present invention is further retouched below in conjunction with the accompanying drawings
State.
A kind of blood pressure measuring method, comprises the following steps:
S1, according to shearing stress τwAnd the relation between velocity of blood flow VRe is Reynolds number, and ρ is blood
Density, sets the expression formula of blood pressure measurement as shrinking pressureDiastolic pressureAS、
ADFor correction factor；
S2, the velocity of blood flow characteristic parameter of acquisition measurement object, utilize piezometer directly to gather this measurement object simultaneously
After blood pressure reference value the expression formula to blood pressure measurement are inversely calculated correction factor value, correction factor value is stored in
It is subordinated in the data base of this measurement object；
S3, when carrying out actual blood pressure and measuring, from data base, read the corresponding correction factor value measuring object, based on blood
The expression formula of pressure measurement and the velocity of blood flow calculation of characteristic parameters blood pressure measurement of Real-time Collection.
According to bernoulli equation in hydrodynamics, equation can be obtained 1.: P+ ρ gz+ (1/2) * ρ v2=C；In formula, P, ρ, v divide
Wei the pressure of fluid, density and speed；Z is vertical height, and g is acceleration of gravity, and that show tube wall pressure in formula is exactly P.
Tube wall pressure can be specified by Bernoulli equation and fluid exists certain physical relation, i.e. blood pressure and deposits with blood and flowing etc. thereof
In physical relation.
For blood vessel, it is believed that be a cylindrical pipeline.2. shearing stress at pipe wall is expressed as equation:There is again equation 3.:4. above-mentioned two formulas of simultaneous obtain equation:Wherein λ
For pipe flow loss factor, ρ is fluid density, and V is the mean flow rate on tube section.
For pipe laminar flow, λ is the most relevant to reynolds number Re, is expressed as equation 5.:
For turbulent flow, substantial amounts of experimentation and theoretical research show, the loss factor λ of Turbulent Pipe Flow is and Reynolds
Number Re and tube wall relative roughness are correlated with, and are i.e. expressed as equation 6.:
Reynolds number (Reynolds number) is a kind of dimensionless number that can be used to characterize fluid mobility status, with Re table
Show, be expressed as equation 7.:Wherein V, ρ, η are respectively the flow velocity of fluid, density and viscosity coefficient, and d is a spy
Levy length.Such as fluid flows through circular pipe, then d is pipe diameter.The flowing utilizing Reynolds number can distinguish fluid be laminar flow or
Turbulent flow, it is possible to be used for determining that object flows suffered resistance in a fluid.
For the present invention, fluid is blood, and fluid density ρ is the density of blood, η and μ i.e. refers to the stickiness system of blood
The thickness of the blood vessel that number (or claiming dynamic viscosity), d value and L-value can near-sighted be thought or caliber, the V i.e. mean flow rate of blood.When
During Re≤2000, it is believed that the flowing in pipe is laminar flow；When Re >=2000, it is believed that the flowing in pipe is turbulent flow；Substantial amounts of experiment
Research and theoretical research show, the Reynolds number representative value of the blood flow in aorta is about Re=1000, i.e. think the flowing of blood
For laminar flow.Therefore, equation 4. 5. draw with equation
In the present invention, described reynolds number Re can use experience constant, or utilizesCalculating gained, η is for surveying
The blood viscosity coefficient of amount object, d is blood vessel diameter.Described density of blood ρ, blood viscosity coefficient η can and be not limited by
The chemical examination of clinical laboratory's routine blood test or other blood pressures obtains, and the thickness of blood vessel i.e. blood vessel diameter d and can be not limited by B ultrasonic and obtains
Take.
In step s 2, the velocity of blood flow characteristic parameter measuring object can use multiple method directly or indirectly to measure
Arrive, survey velocity of blood flow, infrared photography, pressure sensing inspection including ultrasonic doppler detection, laser-Doppler detection, distance between two points
Survey method etc..In an embodiment of the present invention, photoplethysmographic tracing is used to obtain the velocity of blood flow measuring object
Characteristic parameter, photoplethysmographic tracing is to utilize photoelectric effect to test out blood mobility status, according to light emission and light
The position difference receiving device can be divided into transmission beam method and bounce technique two kinds, uses the light of a kind of wave frequency to measure, it is possible to
Utilize the light of multi-frequency with the use of measurement.The monitoring position of transmission beam method is the human body limb thickness such as ear lobe or finger
Little, vascular blood flow is the most local, places the photoelectric receiving arrangement of light-emitting device and respective frequencies respectively in limbs both sides,
As placed light emitting devices above fingernail, below finger, at fingerprint, place optical pickup apparatus.When light-wave irradiation human body limb
Time, the photon of a part, by transmission limbs, is received by photoelectric receiving arrangement, and the photon of another part will be reflected and disappear
Consume, or by limb tissue absorption etc., do not received by photoelectric receiving arrangement.The monitoring position of bounce technique is human body limb
Any one vascular blood flow is the most local, such as position at finger, wrist joint etc., places in the same side of limbs and sends out
Electro-optical device and the photoelectric receiving arrangement of respective frequencies, as placed light emitting devices and optical pickup apparatus side by side at finger print.
When light-wave irradiation human body limb, the photon of a part will be reflected by limbs and blood, be received by photoelectric receiving arrangement,
The photon of another part will be transmitted or scatter and consume, or by limb tissue absorption etc., the most not by photoelectric receiving arrangement institute
Receive.In two kinds of methods, method of testing is different, and it is the most all to receive, by photoelectric receiving arrangement, the photon of returning, and passes through
Circuit conversion is photoelectric current and gets simulation electronic waveform after the processing of circuit such as amplification, filtering, two kinds of method acquisitions
Waveform is morphologically almost consistent.This waveform can reflect the flow condition of blood of human body, and medically the method obtains
Simulation electronic waveform is referred to as pulse wave.
Pulse wave is through circuit design or the method such as is wirelessly transferred, and can be input to the chip of operation processing function
In, such as Micro-processor MCV, the parameter such as flow velocity that can calculate blood in MCU through certain algorithm.Pulse wave is test department
The reflection of position blood mobility status, the change of pulse wave is then caused by ventricular systole and diastole.Work as ventricular systole, blood
Flowing into tremulous pulse from ventricle, now blood is the highest to the pressure of tremulous pulse, is referred to as shrinking pressure；Working as ventricular diastole, arteries elasticity is returned
Contracting, blood the most slowly continues flow forward, but blood pressure drops, pressure now is referred to as diastolic pressure.In wave tops somewhere, it it is the heart
The reflection penetrating blood is shunk in room；Somewhere bottom waveform, is diastolic reflection.Circuit design is utilized to be processed by the photon obtained
After, waveform is processed by the AD conversion mouth of the Waveform Input drawn to microprocessor.At wave tops, microprocessor gets
AD value maximum, the velocity of blood flow this moment flowing through tested place blood vessel is maximum；Bottom waveform, the AD value that microprocessor gets
Minimum, the velocity of blood flow this moment flowing through tested place blood vessel is minimum.When the AD value of wave tops and bottom is i.e. illustrated same
Between in length the flow of blood different, microprocessor obtains the reflection that AD value is i.e. blood flow.
In step s 2, photoplethysmographic tracing is used to obtain the velocity of blood flow characteristic parameter measuring object, bag
Include:
S21, measure and record photoplethysmographic signal, the waveform obtained is obtained after AD conversion reflection blood stream
Real-time AD value Q of amountAD；
S22, the quadratic equation setting up velocity of blood flow V are QAD=α V2+ β V+ γ, α, β, γ are correction factor, determine blood
Flow velocity
In step S22, set up AD value Q that microprocessor obtainsADFollowing relation with velocity of blood flow V: QAD=α V2+βV+
γ.Work as β2-4α(γ-QAD) ＜ 0 time,Obviously, QADIt is the reflection of flow velocity, QADCertainly exist relation with V, give up
This formula.Work as β2=4 α (γ-QADDuring) >=0, drawTwo solutions do not meet containing one
Actual value, gives up it.
In this embodiment, with real-time AD value QADAs the velocity of blood flow characteristic parameter of measurement object, described velocity of blood flow V
Expression formula with real-time AD value QADFor variable and comprise correction factor, the velocity of blood flow V drawn through step S22 is updated to formulaIn, can show that the shearing stress expression formula of correspondence is:
τ is pressed with shrinking based on shearing stresswS, diastolic pressure τwDRelation, determine contraction pressure τwSWith diastolic pressure τwDExpression formula divide
It is not:
In another embodiment of the invention, described step S2 obtains the velocity of blood flow characteristic parameter of measurement object is to adopt
Velocity of blood flow V is gathered, using velocity of blood flow V as the velocity of blood flow characteristic parameter measuring object by ultrasonic Detection Method.Utilize super
The method of acoustic measurement velocity of blood flow includes time difference method and frequency-difference method, no matter uses which kind of method, the flow velocity of the blood obtained
It is consistent that waveform describes.Application laser detection method in another kind embodiment of the present invention measures the principle of velocity of blood flow with ultrasonic
Ripple detection method is similar.
As shown in Figure 3, a pair operating frequency is that ultrasonic transducer P1 and P2 of f is arranged on the both sides of blood vessel (in reality
In the application of border, ultrasonic transducer may be installed the both sides, position such as arm), if distance is L, it is θ with blood vessel angle, ultrasound wave exists
Speed in blood is c, and the flow velocity of blood is V.When P1 send ultrasonic pulse along L propagate to P2 receive time, when recording its following current
Between t12；Now along acoustic speed of propagation c of L1=c+V cos θ (formula a1), wherein(formula a2)；Equally, send ultrasonic as P2
Pulse along L propagate to P1 receive time, record its adverse current time t21；Now along acoustic speed of propagation c of L2=c-V cos θ (formula b1),
Wherein(formula b2).
Can be obtained by formula a1, formula a2, formula b1, formula b2(formula c)；Or, utilizeObtain(formula d)；
Formula c, formula d all can be as the expression formulas of velocity of blood flow, although the mode of expression is different, but the final waveform obtained
Form is consistent.In actual applications, control in real time to send ultrasonic pulse by processor or microprocessor, and obtain in real time
Take the time of ultrasonic pulse, all can obtain real-time velocity of blood flow V by formula c or formula d.
In described step S2, directly gather measurement by electric sphygmomanometer or mercurial sphygmomanometer or spring meter type blood pressure meter right
The contraction pressure τ of elephantwSWith diastolic pressure τwD, recycling shrinks pressure τwSWith diastolic pressure τwDExpression formula be inversely calculated measurement
After the correction factor value of object, this correction factor value is stored in data base.Either normal person or hypertensive patient,
Blood pressure is all in obvious undulatory property.In daily life, along with sleeping and clear-headed, day and night, the replacement had a rest and move,
Blood pressure also has the fluctuation of rhythmicity.The pressure value of people was change curve in the middle of one day, such as various forms such as double peaks types.Blood pressure
The change curve of normal crowd and hyperpietic is not quite similar.Within the regular hour, blood vessel thickness and the blood of human body is close
The parameter of degree is regarded as invariable, utilizes traditional electric sphygmomanometer or mercurial sphygmomanometer can record same person not
With many groups of time point contraction pressures and diastolic pressure, using the data that record as reference, substitute into above-mentioned contraction pressure τwSWith diastolic pressure τwD
Expression formula in, in conjunction with microprocessor obtain real-time AD value QADOr velocity of blood flow V i.e. can determine that each correction factor etc., thus
Complete the calibration of individual's constant.For different individuals, different correction factors will be had to correspond, need to be by traditional electricity
Sub-sphygomanometer or additive method obtain how group statistical data, as foundation, draws the correction factor of different individual.
The present invention blood pressure measuring method also include: pre-build the data base measuring object, gather and measure object
Density of blood ρ, blood viscosity coefficient η, blood vessel diameter d are also stored in data base as feature constant.Blood due to human body
Density and blood vessel thickness not constancy, re-scale after needing a period of time, each group of constant and correction factor can only
Correspondence user targetedly, can preserve the data of the different client of many groups, need to change constant when measuring every time in same equipment.
For the acquisition process of described blood pressure, when practical operation, can increase other feature constants as reference frame and/
Or for corrected Calculation pressure value.Other feature constants described refer to except comprise the density of described blood, the thickness of blood vessel or
Caliber, the sticky coefficient of blood, blood flow velocity outside, other related physiological parameters of human body one or more all at described model
In enclosing, such as content of hemoglobin, the degree of roughness of skin, heart rate and change thereof in platelet content, blood in body temperature, blood
HbO2 Oxyhemoglobin ratio, blood sugar content etc. in change situation, blood.
Feature constant of the present invention is not necessarily obtained by photoelectric effect, can obtain by other means, as
The thickness of blood vessel or caliber can be obtained by laser or X-ray, and body temperature can be obtained by the sensor of semiconductor principle.Described
Other feature constants are not intended to mainly calculate, and refer to can be not only used for auxiliary and calculate and obtain pressure value, it is also possible to as reference and/
Or the various parameter values used time during corrected Calculation.
As shown in Figure 1, present invention also offers the blood pressure measurement side based on photoplethysmographic of a kind of embodiment
Method, comprises the following steps:
S101, setting up the data base measuring object, this data base includes measuring the density of blood ρ of object, blood stickiness system
Number feature constant and the correction factor value such as η, blood vessel diameter d；
S102, measure and record photoplethysmographic signal；
S103, the waveform obtained is obtained after AD conversion reflection blood flow real-time AD value QAD；
S104, the correction factor value reading measurement object from data base and feature constant；
S105, real-time AD value, correction factor value and feature constant are substituted into respectively the expression formula of blood pressure measurement；
S106, calculating blood pressure measurement also show.
As shown in Figure 2, present invention also offers the blood pressure measurement tested the speed based on ultrasonic blood of another kind of embodiment
Method, comprises the following steps:
S201, setting up the data base measuring object, this data base includes measuring the density of blood ρ of object, blood stickiness system
Number feature constant and the correction factor value such as η, blood vessel diameter d；
S202, the ultrasonic transducer of the palm both sides being arranged on measurement object receive ultrasonic pulse；
S203, calculate real-time blood flow rate V according to reception time difference of two ultrasonic transducers；
S204, the correction factor value reading measurement object from data base and feature constant；
S205, real-time blood flow rate V, correction factor value and feature constant are substituted into respectively the expression formula of blood pressure measurement；
S206, calculating blood pressure measurement also show.
The invention also discloses a kind of blood pressure measuring system, as shown in Figure 4, including:
Expression formula derivation module 41, for according to shearing stress τwAnd the relation between velocity of blood flow VRe
For Reynolds number, ρ is density of blood, sets the expression formula of blood pressure measurement as shrinking pressureDiastolic pressureAS、ADFor correction factor；
Data acquisition module 42, for obtaining the velocity of blood flow characteristic parameter measuring object, utilizes piezometer direct simultaneously
Gather after measuring the blood pressure reference value of object and the expression formula of blood pressure measurement being inversely calculated correction factor value, will repair
Positive coefficient value is stored in the data base being subordinated to this measurement object；
Result computing module 43, for when carrying out actual blood pressure and measuring, reads corresponding measurement object from data base
Correction factor value, the velocity of blood flow calculation of characteristic parameters blood pressure measurement of expression formula based on blood pressure measurement and Real-time Collection.
The described reynolds number Re of the present invention uses experience constant, or utilizesCalculating gained, η is right for measuring
The blood viscosity coefficient of elephant, d is blood vessel diameter.
Described data acquisition module 32 measure the velocity of blood flow characteristic parameter of object can use multiple method directly or
Connect measurement to obtain, survey velocity of blood flow, infrared photography, pressure including ultrasonic doppler detection, laser-Doppler detection, distance between two points
Power sensing detection method etc..In an embodiment of the present invention, described data acquisition module 32 is retouched by photoplethysmographic
Notation obtains the velocity of blood flow characteristic parameter measuring object, including: it is used for measuring and recording photoplethysmographic signal, will
The waveform arrived obtains real-time AD value Q of reflection blood flow after AD conversionAD；For setting up the quadratic equation of velocity of blood flow V it is
QAD=α V2+ β V+ γ, α, β, γ are correction factor, determine velocity of blood flow
In this embodiment, bounce technique or transmission measurement photoplethysmographic signal are used.By velocity of blood flow V generation
Enter in the expression formula of blood pressure measurement, obtain shrinking pressure τwSWith diastolic pressure τwDExpression formula be respectively as follows:
In another embodiment of the invention, described data acquisition module 42 obtains the velocity of blood flow feature measuring object
Parameter is to use ultrasonic Detection Method to gather velocity of blood flow V.
Described data acquisition module 42 is directly gathered by electric sphygmomanometer or mercurial sphygmomanometer or spring meter type blood pressure meter
Measure the contraction pressure τ of objectwSWith diastolic pressure τwD, recycling shrinks pressure τwSWith diastolic pressure τwDExpression formula inversely calculate
After the correction factor value of measurement object, this correction factor value is stored in data base.
The blood pressure measuring system of the present invention also includes data base's creation module 44, for pre-building the number measuring object
According to storehouse, gather and measure the density of blood ρ of object, blood viscosity coefficient η, blood vessel diameter d and be stored in data as feature constant
In storehouse.
In a preferred embodiment of reality of the present invention application, blood pressure measuring system based on photoplethysmographic loads
In an Intelligent worn device, in especially one wristband type universal serial or watch style Intelligent worn device.Described Intelligent worn device is integrated
Photoelectricity blood pressure detecting function, use green-light source, use bounce technique test, as shown in Figure 5, including MCU (refer to microprocessor,
The most any one or more chips with disposal ability, including single-chip microcomputer, ARM, CPU, DSP etc.), power supply, pulse wave monitoring
Partly, other parameter detecting parts, wireless communication apparatus and display device.As a example by intelligent watch, can be bottom watch core
Place light-emitting device and the photoelectric receiving arrangement of pulse wave monitoring part, obtain the pulse wave of human body by controlling luminous intensity
Shape, combines feature constant through MCU process and calculates the flow velocity of blood.On the other hand, the density of the blood of testee, blood
Sticky coefficient can be obtained by the chemical examination of clinical laboratory's routine blood test or other blood.The thickness of blood vessel i.e. caliber can pass through B
Super acquisition.Intelligent watch has the feature constants such as the thickness of correction factor and the density of blood, the sticky coefficient of blood, blood vessel to set
Putting, testee can real-time update relevant parameter.The process of pulse wave can be obtained by the flow velocity of blood by microprocessor,
The change in flow curve of blood flowing can be got by algorithm, and then combine fluctuation point and relevant parameter, by micro-process
Device can be calculated pressure value.The pressure value drawn can show or by being wirelessly transmitted to background system, and pressure value is used
Doctor in specialty is analyzed.
In another preferred embodiment of reality of the present invention application, integrated pulse ripple monitoring function on intelligent watch (or energy
Calculate the flow velocity of blood) and other parameter detecting parts, numerical value detection obtained by communicating portion mails to backstage
Surveillance center.Surveillance center has the correction factor of measurand and various feature constant, as the density of blood, blood sticky
Coefficient, the thickness i.e. caliber etc. of blood vessel.Pulse wave that Surveillance center is obtained by intelligent watch or the flow velocity of blood and other
Auxiliary physiological parameter, in conjunction with the existing correction factor of Surveillance center and feature constant, then by processor calculate measured ought
Front blood pressure situation.
Above content is to combine concrete optimal way further description made for the present invention, should not assert this
Bright be embodied as being confined to described above.For those skilled in the art, without departing from present inventive concept
On the premise of, it is also possible to making some simple deduction or replace, the claim being regarded as being submitted to by the present invention determines
Within protection domain.
Claims (2)
1. a blood pressure measuring system, it is characterised in that described blood pressure measuring system is based on photoplethysmographic, and it loads
In Intelligent worn device, described Intelligent worn device includes MCU and pulse wave monitoring part, described blood pressure measuring system bag
Include:
Expression formula derivation module, for according to shearing stress τwAnd the relation between velocity of blood flow VRe is Reynolds
Number, ρ is density of blood, set the expression formula of blood pressure measurement as
AS、ADFor correction factor；
Data acquisition module, for obtaining the velocity of blood flow characteristic parameter measuring object, utilizes piezometer directly to gather survey simultaneously
The blood pressure reference value of amount object after the expression formula of blood pressure measurement is inversely calculated correction factor value, by correction factor
Value is stored in the data base being subordinated to this measurement object；
Result computing module, for when carrying out actual blood pressure and measuring, reads the corresponding correction system measuring object from data base
Numerical value, the velocity of blood flow calculation of characteristic parameters blood pressure measurement of expression formula based on blood pressure measurement and Real-time Collection；Wherein, blood
Pressure value is calculated by MCU；
Wherein, described data acquisition module directly gathers survey by electric sphygmomanometer or mercurial sphygmomanometer or spring meter type blood pressure meter
The contraction pressure τ of amount objectwSWith diastolic pressure τwD, recycling shrinks pressure τwSWith diastolic pressure τwDExpression formula be inversely calculated
After measuring the correction factor value of object, this correction factor value is stored in data base；
Described pulse wave monitoring part includes light-emitting device and photoelectric receiving arrangement, obtains the arteries and veins of human body by controlling luminous intensity
Fight waveform, combine feature constant through MCU process and calculate velocity of blood flow.
Blood pressure measuring system the most according to claim 1, it is characterised in that: also include data base's creation module, be used for
Pre-build the data base measuring object, gather and measure the density of blood ρ of object, blood viscosity coefficient η, blood vessel diameter d and make
It is characterized constant to be stored in data base.
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| CN106618540B (en) * | 2015-11-03 | 2020-01-17 | 深圳市维亿魄科技有限公司 | Non-invasive blood pressure detection method and non-invasive blood pressure detection device |
| CN106419883B (en) | 2016-10-20 | 2018-06-12 | 京东方科技集团股份有限公司 | A kind of measuring method and sphygmomanometer of detection time point |
| JP2018201823A (en) * | 2017-06-02 | 2018-12-27 | 株式会社ジェイ・エム・エス | Ultrasound measurement apparatus and extracorporeal circulation apparatus |
| CN110448279A (en) * | 2019-09-18 | 2019-11-15 | 东莞市好康电子科技有限公司 | A kind of heart frequency spectrum sphygmomanometer and heart frequency spectrum detection system |
| CN110477888A (en) * | 2019-09-25 | 2019-11-22 | 江苏启润科技有限公司 | Vehicle-mounted human multi-parameter monitors terminal |
| CN111904404B (en) * | 2020-08-06 | 2021-06-18 | 苏州国科医工科技发展(集团)有限公司 | Blood pressure regulation and control equipment containing closed-loop monitoring and based on ear vagus nerve stimulation |
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