CN103543539B - A kind of method that cornea reducing contact lens wearer pollutes - Google Patents
A kind of method that cornea reducing contact lens wearer pollutes Download PDFInfo
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- CN103543539B CN103543539B CN201310484548.3A CN201310484548A CN103543539B CN 103543539 B CN103543539 B CN 103543539B CN 201310484548 A CN201310484548 A CN 201310484548A CN 103543539 B CN103543539 B CN 103543539B
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Abstract
The present invention provides the lens that a kind of surge pressure below lens wearer eyelid reduces.The present invention provides a kind of lens design, and this lens design can be reduced or eliminated the mechanical friction of the cornea in the lens even made of high modulus material.
Description
The application be Application No. 200480044387.5 (international application no is PCT/US2004/037836),
Filing date on November 12nd, 2004, invention entitled " a kind of cornea reducing contact lens wearer is dirty
The method of dye " the divisional application of application for a patent for invention.
Technical field
The present invention relates to contact lens.Particularly, the present invention provides a kind of cornea dirt making lens wearer
The lens occurring to reduce of dye (corneal staining).
Background technology
Employing contact lens corrects visual sensitivity or is well-known for cosmetic purpose.Soft contact is saturating
Mirror is known, and generally, the making material of this lens includes but not limited to hydrogel and siloxanes aquogel.
In the eyes of the normal lens wearer used, a part for soft-contact lens covers wearer's
On cornea.The keratocyte damage polluted by cornea or observe after anterior corneal surface instils diagnosis dyestuff can be sent out
It is born in soft-contact lens wearer.Particularly noteworthy is that lens mechanical friction on cornea causes polluting.
This pollution is considered as a kind of indication of cornea tissue division.Lathe cutting lens are being worn in this damage,
The lens made of material that Young's modulus is 40psi (pound/square inch) or bigger, have single after
The lens of surface curvature, and center thickness, perimeter thicknesses section, or tranverse sectional thickness or both thickness are all
All observe more than in the wearer of the lens of 0.1mm.
Additionally, keratocyte damage is wearing front surface or rear surface has the pendant of lens of geometry in particular
Wearer observes.The geometry gone wrong especially is those districts on lens front surface or rear surface
Connection between territory causes the middle outer region at lens to occur that surface is discontinuous.
Summary of the invention
The purpose of the present invention, because middle outer region is it in the light school district of lens geometric center and rims of the lens
Outer non-optical regions, when lens are worn on eyes, this region is covering on cornea.Typically, this district
Territory has the radius of about 3.5 to 6.5mm from lens geometric center.Finally, it is not normal for having thickness distribution
The lens in the region of number can cause keratocyte to damage.
The cornea pollution caused due to mechanical friction most commonly occurs at cornea upper area, or above pupil
Pupil region, and Trans-corneal inferior region, or the region below pupil.Therefore, cell injury most probable occurs
Pupil region below upper eyelid or palpebra inferior.Occur the probability that cornea pollutes with the material of lens and design
Change, but can reach the 50% of lens wearer.Accordingly, there exist one makes cornea pollute incidence rate reduction
Or the demand of the lens design disappeared.
Accompanying drawing explanation
Fig. 1 is the lens sectional view that the present invention amplifies.
Fig. 2 is the plan view of the lens front surface amplification of Fig. 1.
Detailed description of the invention
The present invention provides a kind of method of cornea pollution probability for reducing lens wearer and uses the method
The lens made.It is believed that the cornea that mechanical friction causes pollutes most frequently by the surge pressure on cornea
(peakpressure) producing, the meaning subjects this lens relative to the close region pupil region of cornea exactly
The bigger pressure in region.Modal, these surge pressure regions occur under lens wearer eyelid
Face.Lens thickness is distributed, or tranverse sectional thickness, in material modulus, and the connection of lens surface areas
Individual or multiple result in described surge pressure.
In one embodiment, the present invention provides a kind of contact lens to include, substantially includes, or include to
A few surface with surge pressure reduction design.
A kind of lens design of the present invention provides an equal thickness vertical section.Wherein " equal thickness is vertically cutd open
Face " the meaning be to measure periphery in the middle of lens between lens front surface and rear surface and along rear surface orthogonal direction
The radial thickness in region is in any meridian side along 45 degree of vertical lens meridian direction (90-270 degree axle)
To being uniformly distributed.Equal thickness vertical section makes in the region around vertical lens meridian direction in the middle of lens
The sectional thickness of outer region is constant.
Fig. 1 shows the lens 10 embodying this design.Middle outer region 11 shows above lens
(top) part and lower section (end) part, employ equal thickness vertical section in the portion.Fig. 2 illustrates
Show the plan view of the lens in the most open and the most flat region 11.
Equal thickness vertical section can by biases upper surface periphery and lower surface periphery formed desired by cut open
Face.This section can be obtained by any method for designing, includes but not limited to, in conjunction with tilting curved surface off axis
Or use multiple perimeter region.Additionally, the method for designing of United States Patent (USP) 6,595,640 can also use, this patent
Content all quote at this.
In another interchangeable embodiment of the present invention, zones of different on one or two surface of lens
Between coupling part be smoothed process, discontinuous to eliminate inclined-plane on rear surface.More particularly, exist
In this embodiment, on rear surface, the first derivative of coupling part between sweep is consistent, i.e.
The bending slope of coupling part is consistent.Any method for obtaining part in smoothing junction includes but does not limits
Two continuous print regions are merged in application conventional mathematical techniques.
The lens of the present invention preferably stablize to keep their orientation towards eyeball rotatably.Suitably rotation
Turning and stably include that prism is stable, prism stably includes, but not limited to the front surface making lens relative to rear table
Face is eccentric, and the balance of prism adds thick prism lower limb, supports lens in lower eyelid, is leaving 90 degree of sons
The lens surface in noon direction forms concave surface or convex surface, and truncate rims of the lens.Alternatively, or combine prism
Stable, lens can be dynamic stability.Dynamic stability includes reducing on two symmetrical regions outside lens
The thickness of perimeter surface, increases the thickness in two regions on horizontal middle spindle, and thinning, or the top of layer stripping lens
District of portion and bottom zone.Typically, stable region is positioned at lens periphery, i.e. around the non-light of lens of light school district
The department of the Chinese Academy of Sciences divides, but does not include rims of the lens and the part relative to geometric center lens ragged edge.
The present invention can be used for designing single vision, multifocal and toric lens.It addition, the present invention can be used for setting
Count the lens made of any applicable contact lens material.While it is true, the improvement of present invention maximum is to pass through
Use the region of different-thickness make lens spin stabilization and/or be about 40psi with yang type modulus in lens periphery
(pound/square inch), preferably about 60psi (pound/square inch), or the material system of higher high-modulus
Make lens.
Exemplary high-modulus lens material includes, but are not limited to hydrogel, and hydrogel includes, but not limited to
etafilconA.Preferably, the present invention is for the lens made by siloxanes aquogel, and siloxanes is such one
Plant material: include one or more component containing siloxanes and one or more hydrophilic component, such as
galyfilcon。
One or more components containing siloxanes and one or more hydrophilic component can be that any use is existing
Have in technology and make part known to siloxanes aquogel.Term " containing the component of siloxanes " and " hydrophilic component "
It is the most mutually exclusive, because the component containing siloxanes can have hydrophilic somewhat and hydrophilic component to wrap
Containing some siloxanes.
Component containing siloxanes includes at least one in monomer, macromonomer, or prepolymer
[-Si-O-Si-] group.Preferably, there are the O of the Si in the component containing siloxanes and connection at content
On exceed 20 weight % of total molecular wt of the component containing siloxanes, or more preferably beyond 30 weight
%.The useful component containing siloxanes preferably comprises polymerisable functional group, such as acrylate, methyl
Acrylate, acrylamide, Methacrylamide, N-vinyl lactam, N-ethernamine, and benzene second
Alkenyl-functional groups.The example of the most useful component containing siloxanes can be in U.S. Patent No.
3,808,178;4,120,570;4,136,250;4,153,641;4,740,533;5,034,461 and 5,070,215
Obtain with in patent EP080539.All above-mentioned patents here quoted are incorporated by reference at this.
The further example of the monomer containing siloxanes being suitable for is polysiloxanylalkyl (methyl) propylene
Acid monomers includes, but is not restricted to, methacryloxypropyl three (trimethylsiloxy) silane,
Pentamethyl dimethylamino silane epoxide methylmethacylate, and methyl two (trimethylsiloxy) methyl
Acryloyloxymethyl silane.
Component preferred class containing siloxanes is poly (organosiloxane) prepolymer, such as α, ω-two
Methacryloxypropyl polydimethylsiloxane.Another preferred example is mPDMS (monomethyl third
Alkene acryloxypropylethoxysilane end list-normal-butyl end polydimethylsiloxane).Useful another kind of of component containing siloxanes
Including vinylcarbonates or the vinyl carbamate monomer of silicone-containing, including, but be not restricted to,
1,3-bis-[4-(ethyleneoxy carboxyl) butyl-1-base] tetramethyl-siloxanes 3-(ethylene oxy carbonyl sulfur generation) third
Base-[three (trimethylsiloxy silanes];3-[three-(trimethylsiloxy) silicyls] propyl group alkene
Propyl carbamate;3-[three (trimethylsiloxy) wilyl] propyl vinyl carbamate;Three
Methyl silicane base ethyl vinyl carbonic ester;With trimethylsilylmethyl vinyl base carbonic ester.
Hydrophilic component includes that those can provide relative to finished lens extremely when combining with rest activity part
The part of the water content of few about 20% preferably at least about 25%.The hydrophilic component being suitable for is relative on content
Weight in all active parts can account for about 10 to about 60 weight %.About 15 to about 50 weights
Amount % or preferred percentage by weight about 20 to about 40 weight %.Can be used for preparing the poly-of the present invention
The hydrophilic monomer of compound has at least one polymerisable double bond and at least one hydrophilic functional groups.Polymerizable double bond
Example includes acrylic, methacrylic acid group, acrylamido, methacryl amido, anti-butylene two
Acyl group, maleoyl, styryl, isopropenyl phenyl, O-vinylcarbonates, O-vinyl
Carbamate, pi-allyl, O-vinylacetyl and N-vinyl lactam and N-vinyl acyl ammonia double bond.
Described hydrophilic monomer itself can serve as cross-linking agent." acrylic-type " or " containing acrylic acid " monomer is that those comprise
The monomer of acryloyl group (CR H=CRCOX).
Wherein R is H or methyl, and R is H, alkyl or carbonyl, and X is O or N, this be known very
Easily it is polymerized, such as N,N-DMAA (DMA), 2-hydroxy ethyl methacrylate, methyl-prop
Olefin(e) acid glyceride, 2-hydroxyethyl methacrylamide, polyethylene glycol monomethacrylate, methacrylic acid,
Acrylic acid and mixture thereof.
The hydrophilic vinyl-containing monomers of hydrogel that can be incorporated herein includes following monomer such as N-vinyl
Lactams (such as NVP (NVP)), N-vinyl-N-methylacetaniide, N-ethylene
Base-N-ethyl acetamide, N-vinyl-N-ethyl formamide, N-vinyl formamide, N-2-hydroxyethyl vinyl
Aminocarbamic acid ester, N-carboxyl β-alanine N-vinyl esters, NVP is preferred.
Other can be answered hydrophilic monomer used in this invention to include with the functional group comprising polymerizable double bond and substitute
The polyoxyethylene polyols of one or more terminal hydroxyls.Example includes with the functional group containing polymerizable double bond
Substitute the Polyethylene Glycol of one or more terminal hydroxyl.Example includes Polyethylene Glycol and one or more moles of ends
End group equivalent reaction generate have one or more by coupling part such as carbamate or ester group
Make one or more terminal polymerizable olefinic group bonding Polyethylene Glycol to Polyethylene Glycol, this END CAPPED GROUP
Roll into a ball and include such as isocyanatoethyl ethyl ester (" IEM "), methacrylic anhydride, methacrylic chloride,
Vinylbenzoyl chloride, etc..
Further example is the hydrophilic vinylic carbonic ester disclosed in United States Patent (USP) 5,070,215 or vinyl
Carbamate monomer and hydrophilic disclosed in United States Patent (USP) 4,190,277Oxazolone monomers.Other is suitable for
Hydrophilic monomer it will be apparent to those skilled in the art that.The preferred polymer introducing the present invention
Hydrophilic monomer includes such as N,N-DMAA (DMA), acrylic acid 2-hydroxyl ethyl ester, metering system
Acid glyceride, 2-hydroxyethyl methacrylamide, NVP (NVP), and polyethyleneglycol
Methacrylate.Most preferably hydrophilic monomer includes DMA, NVP and its mixture.
The solidification of lens material can be carried out by any traditional method.Such as, material can use mould
Deposit and by heat, radiate, chemistry, electromagnetic radiation curable etc. and combinations thereof.Preferably, ultraviolet light is used
Or use the full spectrum of visible ray to carry out molding.More specifically, be suitable for the accurate bar of cured lens material
Part depends on the lens of material and the wanted molding selected.United States Patent (USP) 4,495,313,4,680,336,
4,889,664,5,039,459 and 5,540,410 disclose applicable technique, are herein incorporated by reference in their entirety.
The contact lens of the present invention can be made by any convenient method.One described method uses car
Bed makes mold insert.Mold insert is used for the most again forming mould.Therefore, a kind of applicable
Lens material is placed between mould the lens being formed the present invention subsequently by compression and solidification resin.This area
Those of ordinary skill could be aware that other any known method that can be used to make lens of the present invention.
Claims (11)
1. a contact lens, has surge pressure including at least one and reduces the surface of design,
It is characterized in that described lens by using the region of different-thickness in periphery and spin stabilization, described spin stabilization is by forming the prism stabilization that concave surface realizes at the lens surface leaving 90 degree of meridian directions,
Lens periphery refers to the lens non-optic portion around light school district, but does not include rims of the lens or the part relative to geometric center lens ragged edge.
2. lens as claimed in claim 1, farther include at least one equal thickness vertical section in outer region in the middle of described lens.
3. lens as claimed in claim 1, farther include following surface: this surface has at least two and has the curve that the slope of coupling part is different therebetween, are wherein consistent at connecting portion office slope of a curve.
4. lens as claimed in claim 1, the Young's modulus of wherein said lens is 40 psi or bigger.
5. lens as claimed in claim 2, the Young's modulus of wherein said lens is 40 psi or bigger.
6. lens as claimed in claim 3, the Young's modulus of wherein said lens is 40 psi or bigger.
7. lens as claimed in claim 1, wherein in lens periphery, spin stabilization includes two symmetrical regions that wherein lens thickness reduces compared with the remaining area of lens periphery.
8. lens as claimed in claim 7, wherein said lens are toric lenses.
9. the method designing contact lens, including providing at least one step on surface that wherein surge pressure reduces,
It is characterized in that described method farther includes by using the region of different-thickness to provide the step of spin stabilization in lens periphery, described spin stabilization is by forming, at the lens surface leaving 90 degree of meridian directions, the prism stabilization that concave surface realizes,
Lens periphery refers to the lens non-optic portion around light school district, but does not include rims of the lens or the part relative to geometric center lens ragged edge.
10. method as claimed in claim 9, farther includes to provide the step of at least one equal thickness vertical section in outer region in the middle of described lens.
11. methods as claimed in claim 9, farther include to provide the step on following surface: this surface has at least two and has the curve that the slope of coupling part is different therebetween, are wherein consistent at connecting portion office slope of a curve.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201310484548.3A CN103543539B (en) | 2004-11-12 | 2004-11-12 | A kind of method that cornea reducing contact lens wearer pollutes |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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CN201310484548.3A CN103543539B (en) | 2004-11-12 | 2004-11-12 | A kind of method that cornea reducing contact lens wearer pollutes |
CN2004800443875A CN101151569B (en) | 2004-11-12 | 2004-11-12 | Methods for reducing corneal staining in contact lens wearers |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN2004800443875A Division CN101151569B (en) | 2004-11-12 | 2004-11-12 | Methods for reducing corneal staining in contact lens wearers |
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CN103543539A CN103543539A (en) | 2014-01-29 |
CN103543539B true CN103543539B (en) | 2016-08-10 |
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CN201310484548.3A Active CN103543539B (en) | 2004-11-12 | 2004-11-12 | A kind of method that cornea reducing contact lens wearer pollutes |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4555372A (en) * | 1981-03-23 | 1985-11-26 | Bausch & Lomb Incorporated | Rotational molding of contact lenses |
US5020898A (en) * | 1990-01-29 | 1991-06-04 | Schering Corporation | Contact lens for correction of astigmatism |
EP0742462A2 (en) * | 1995-05-04 | 1996-11-13 | JOHNSON & JOHNSON VISION PRODUCTS, INC. | Programmable smooth junctions on lenses |
JP2002182167A (en) * | 2000-12-11 | 2002-06-26 | Toray Ind Inc | Plastic molding and contact lens consisting of it |
WO2004097502A1 (en) * | 2003-05-02 | 2004-11-11 | Vision Crc Limited | Design and calculation of post-lens pressure profile for conatact lens |
-
2004
- 2004-11-12 CN CN201310484548.3A patent/CN103543539B/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4555372A (en) * | 1981-03-23 | 1985-11-26 | Bausch & Lomb Incorporated | Rotational molding of contact lenses |
US5020898A (en) * | 1990-01-29 | 1991-06-04 | Schering Corporation | Contact lens for correction of astigmatism |
EP0742462A2 (en) * | 1995-05-04 | 1996-11-13 | JOHNSON & JOHNSON VISION PRODUCTS, INC. | Programmable smooth junctions on lenses |
JP2002182167A (en) * | 2000-12-11 | 2002-06-26 | Toray Ind Inc | Plastic molding and contact lens consisting of it |
WO2004097502A1 (en) * | 2003-05-02 | 2004-11-11 | Vision Crc Limited | Design and calculation of post-lens pressure profile for conatact lens |
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CN103543539A (en) | 2014-01-29 |
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