CN103494940B - A kind of medicine for external use for the treatment of rosacea and preparation method thereof - Google Patents
A kind of medicine for external use for the treatment of rosacea and preparation method thereof Download PDFInfo
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- 238000002360 preparation method Methods 0.000 title abstract description 6
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- 241000628997 Flos Species 0.000 claims abstract description 8
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 8
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- IECPWNUMDGFDKC-MZJAQBGESA-N fusidic acid Chemical compound O[C@@H]([C@@H]12)C[C@H]3\C(=C(/CCC=C(C)C)C(O)=O)[C@@H](OC(C)=O)C[C@]3(C)[C@@]2(C)CC[C@@H]2[C@]1(C)CC[C@@H](O)[C@H]2C IECPWNUMDGFDKC-MZJAQBGESA-N 0.000 description 2
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- OJMMVQQUTAEWLP-KIDUDLJLSA-N lincomycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@@H](C)O)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 OJMMVQQUTAEWLP-KIDUDLJLSA-N 0.000 description 2
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Abstract
The invention discloses a kind of medicine for external use for the treatment of rosacea and preparation method thereof, component takes by weight: Lithargyrum 50-60 gram, Radix Scrophulariae 20-30 gram, sulfur 20-30 gram, Calomelas 20-25 gram, Radix Paeoniae Rubra 6-10 gram, Radix Angelicae Dahuricae 6-10 gram, Radix Angelicae Sinensis 6-10 gram, Flos Carthami 6-10 gram, Radix Glycyrrhizae 6-10 gram, Rhizoma Chuanxiong 4-6 gram; Above-mentioned raw materials is ground into end, is blended into Mel in medicamental pulverata and is modulated into paste; During use, paste is applied in affected part, every day each 1 time sooner or later, within 1 month, be a course for the treatment of, treatments period, prohibits against alcoholic drinks and coordinates light diet.The present invention adopts common pure Chinese medicine to make, and makes simple, with low cost, effectively can treat rosacea; Confirm through Clinical practice, treatment rosacea total effective rate reaches more than 90%, does not recur.
Description
Technical field
The present invention relates to a kind of medicine for external use for the treatment of rosacea and preparation method thereof.
Background technology
Rosacea is common with middle age, is apt to occur in the middle part of face, and characteristic of damage is erubescence, papulopustule and telangiectasis appear in injustice, follicular orifice.Its course of disease is slow, is usually divided into for three phases, does not have obvious boundary between each phase: 1. the erythema telangiectasis phase: show as the erythema based on Middle face, also can add up buccal, forehead and lower chin.Show as erythema at first, can pungent stimulation food, temperature cataclysm and spiritual nervous excitation time be obvious on the feed, of a specified duration becomes erythema perstans, and engenders telangiectasis, in dendroid, is mainly distributed in nose and the wing of nose.Often increase with corse sweat pore and sebum secretion.The sustainable several months, to the several years, transfers the papulopustule phase to afterwards.2. papulopustule phase: in erythema and telangiectatic basis, the repeatedly pityriasis rubra pimple of acne sample, pustule, but formed without acne.Skin lesion sometimes can show as deeply struvite tuberosity or cyst.3. the pachydermatosis phase: due to long-term hyperemia, repeated infection, nose connective tissue propagation, sebaceous gland are abnormal to be increased, and forms the protuberance tuberosity differed in size, and cause nose portion outward appearance loose, deformity is as vegetation.The visible sebaceous gland mouth obviously expanded in pachydermatosis surface, has strip thick white seborrhea during extruding.
The definite cause of disease of rosacea it be unclear that up till now, many factors all likely brings out or aggravates disease, comprise local vascular to relax contracting nervous disorder, demodex folliculorum and local repeated infection, use maror, drink, caloric stimulation, psychentonia, excited, endocrine dysfunction etc.
The current treatment means for rosacea is mainly divided two classes, and medicine for external use controls portion and interior application treatment; The anti-inflammation and sterilization medicines such as medicine for external use many employings lincomycin, Fusidic Acid Cream, Metrogel, the oral medicines such as the many employing tinidazoles of innerlich anwenden, tetracycline, but said medicine is not only containing antibiotic composition and some other harmful chemicals composition, should not use numerous crowd, and because treatment primary disease is medication in genus etiology unknown situation, greatly exploratory, often cause treatment cycle long, even increase the weight of the state of an illness to patient, cause more misery.
Summary of the invention
Sent out and overcome above-mentioned defect, the object of the present invention is to provide a kind of good effect, do not recur, not containing any chemicals, the medicine for external use that pure Chinese herbal medicine without any side effects is made, effectively can treat rosacea.
The present invention treats the medicine for external use of rosacea, is made up of the raw material of following weight component:
Lithargyrum 50-60 gram, Radix Scrophulariae 20-30 gram, sulfur 20-30 gram, Calomelas 20-25 gram, Radix Paeoniae Rubra 6-10 gram, Radix Angelicae Dahuricae 6-10 gram, Radix Angelicae Sinensis 6-10 gram, Flos Carthami 6-10 gram, Radix Glycyrrhizae 6-10 gram, Rhizoma Chuanxiong 4-6 gram.
Treat a medicine for external use for rosacea, it is characterized in that its preparation method comprises the following steps:
(1), component takes above-mentioned raw materials and grinds into end by weight;
(2), be blended into Mel in medicamental pulverata and be modulated into paste.
Treat a medicine for external use for rosacea, its Therapeutic Method is as follows:
Paste is applied in affected part, and every day each 1 time sooner or later, within 1 month, be a course for the treatment of, treatments period, prohibits against alcoholic drinks and coordinates light diet.
The present invention's medicine main pharmacological used effect: Lithargyrum: dampness, parasite killing, sore; Radix Scrophulariae: clearing away heat and cooling blood, eliminating fire and detoxication, YIN nourishing; Sulfur: disinfection, dampness removing to stop itchin; Calomelas: control that sputum is stagnant, edema tympanites, skin infection; Radix Paeoniae Rubra: clots absorbing, pain relieving, removing heat from blood, detumescence; The Radix Angelicae Dahuricae: expelling wind and cold, understand things pain-stopping, detumescence and apocenosis, dampness leukorrhagia stopping; Radix Angelicae Sinensis: enrich blood invigorate blood circulation, menstruction regulating and pain relieving, ulcer sores; Flos Carthami: promoting blood circulation to restore menstrual flow; Radix Glycyrrhizae: heat-clearing and toxic substances removing; Rhizoma Chuanxiong: blood circulation promoting and blood stasis dispelling, activating QI to alleviate the depression, wind-expelling pain-stopping; Said herbal medicine is comprehensively risen in rebellion and is had effect of heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, detoxicating and killing parasites, to rosacea disease treating both the principal and secondary aspects of a disease, has no side effect.
Effect of the present invention: the present invention adopts common pure Chinese medicine to make, and makes simple, with low cost, effectively can treat rosacea; Confirm through Clinical practice, treatment rosacea total effective rate reaches more than 90%, does not recur.
Detailed description of the invention
Preparation and use:
Embodiment 1: component takes by weight: Lithargyrum 50-60 gram, Radix Scrophulariae 20-30 gram, sulfur 20-30 gram, Calomelas 20-25 gram, Radix Paeoniae Rubra 6-10 gram, Radix Angelicae Dahuricae 6-10 gram, Radix Angelicae Sinensis 6-10 gram, Flos Carthami 6-10 gram, Radix Glycyrrhizae 6-10 gram, Rhizoma Chuanxiong 4-6 gram; Above-mentioned raw materials is ground into end, is blended into Mel in medicamental pulverata and is modulated into paste; During use, paste is applied in affected part, every day each 1 time sooner or later, within 1 month, be a course for the treatment of, treatments period, prohibits against alcoholic drinks and coordinates light diet.
Embodiment 2: component takes by weight: Lithargyrum 50 grams, Radix Scrophulariae 20 grams, sulfur 20 grams, Calomelas 20 grams, Radix Paeoniae Rubra 6 grams, the Radix Angelicae Dahuricae 6 grams, Radix Angelicae Sinensis 6 grams, 6 grams, Flos Carthami, 6 grams, Radix Glycyrrhizae, Rhizoma Chuanxiong 4 grams; Above-mentioned raw materials is ground into end, is blended into Mel in medicamental pulverata and is modulated into paste; During use, paste is applied in affected part, every day each 1 time sooner or later, within 1 month, be a course for the treatment of, treatments period, prohibits against alcoholic drinks and coordinates light diet.
Embodiment 3: component takes by weight: Lithargyrum 60 grams, Radix Scrophulariae 30 grams, sulfur 30 grams, Calomelas 25 grams, Radix Paeoniae Rubra 10 grams, the Radix Angelicae Dahuricae 10 grams, Radix Angelicae Sinensis 10 grams, 10 grams, Flos Carthami, 10 grams, Radix Glycyrrhizae, Rhizoma Chuanxiong 6 grams; Above-mentioned raw materials is ground into end, is blended into Mel in medicamental pulverata and is modulated into paste; During use, paste is applied in affected part, every day each 1 time sooner or later, within 1 month, be a course for the treatment of, treatments period, prohibits against alcoholic drinks and coordinates light diet.
Embodiment 4: component takes by weight: Lithargyrum 55 grams, Radix Scrophulariae 25 grams, sulfur 25 grams, Calomelas 22 grams, Radix Paeoniae Rubra 8 grams, the Radix Angelicae Dahuricae 8 grams, Radix Angelicae Sinensis 8 grams, 8 grams, Flos Carthami, 8 grams, Radix Glycyrrhizae, 5 grams, river; Above-mentioned raw materials is ground into end, is blended into Mel in medicamental pulverata and is modulated into paste; During use, paste is applied in affected part, every day each 1 time sooner or later, within 1 month, be a course for the treatment of, treatments period, prohibits against alcoholic drinks and coordinates light diet.
Clinical practice and analysis of cases:
1, clinical data: random selecting 2007-2012 clinic case 46 example, wherein male 21 example, women 25 example, is divided into treatment group 31 example at random, matched group 15 example.
2, clinical criteria: in three courses for the treatment of condition of illness completely without, be cure, in three courses for the treatment of, condition of illness is clearly better, and what need the follow-up 4-6 of being increased to course for the treatment of to cure be effective, treats after reaching 6 courses for the treatment of and still has condition of illness, and what entirely do not heal is invalid.
3, criterion of therapeutical effect judges: the local such as pustule and edema skin lesion characterizes:
Cure: in three courses for the treatment of pustule and edema completely without;
Effective: in three to six courses for the treatment of pustule and edema completely without;
Invalid: after six courses for the treatment of, still there are pustule and edema condition of illness or part condition of illness.
4, therapeutic outcome analysis: adopt Drug therapy hair loss patient result of the present invention as table 1, treatment group in totally 31 routine patients in three courses for the treatment of pustule and edema completely without have 27 examples; In three to six courses for the treatment of pustule and edema completely without have 3 examples; Cure rate is 84.78%, and total effective rate is 97.82%, and result in clinical application shows, does not go out incumbent side effect and untoward reaction after using medicine of the present invention.
Table 1 medicine of the present invention and treatment of control group result
| Group | Number of cases | Cure | Effectively | Invalid | Total effective rate % |
| Treatment group | 31 | 26 | 3 | 2 | 93.54 |
| Matched group | 15 | 8 | 4 | 3 | 80 |
The routine patient medication of matched group 15 adopts commercially available lincomycin to coordinate Fusidic Acid Cream, uses by specification method to carry out.
5, observation of curative effect and model case explanation
Model case 1
Patient Jiang, man, 43 years old, Suzhou City people from Sixian County, Anhui, came the court and uses medicine of the present invention and method treatment, the recovery from illness course for the treatment of.
Model case 2
The Qin, female, 47 years old, people from Xuzhou, 2010 low come medical time, its nose is congested for a long time to be infected, place's pachydermatosis phase, and come the court and use medicine of the present invention and method treatment, fully recover after two courses for the treatment of, the end of the year pays a return visit, and does not recur.
Model case 3
Hu, female, 45 years old, people from Wuhe County, Bengbu, came the court and uses medicine of the present invention and method treatment, fully recover after three courses for the treatment of.
Claims (1)
1. treat a medicine for external use for rosacea, it is characterized in that the weight portion of its constitutive material is: Lithargyrum 55 grams, Radix Scrophulariae 25 grams, sulfur 25 grams, Calomelas 22 grams, Radix Paeoniae Rubra 8 grams, the Radix Angelicae Dahuricae 8 grams, Radix Angelicae Sinensis 8 grams, 8 grams, Flos Carthami, 8 grams, Radix Glycyrrhizae, Rhizoma Chuanxiong 5 grams.
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| CN201310459069.6A CN103494940B (en) | 2013-10-07 | 2013-10-07 | A kind of medicine for external use for the treatment of rosacea and preparation method thereof |
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| CN103494940B true CN103494940B (en) | 2015-09-30 |
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| CN101147763A (en) * | 2006-09-18 | 2008-03-26 | 张爱平 | Orally-administered medicine for treating chloasma |
| CN101181524A (en) * | 2007-11-20 | 2008-05-21 | 孙远贵 | Chinese medicine medical ointment for curing exogenous injury taint and pyogenic infection as well as preparation method thereof |
| CN102342985A (en) * | 2010-07-28 | 2012-02-08 | 陈登 | Chinese medicinal prescription for treating chloasma |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR201911199T4 (en) * | 2009-03-27 | 2019-08-21 | Moleac Pte Ltd | Treatment to increase cell growth. |
| AU2012286671B2 (en) * | 2011-07-28 | 2017-07-20 | Santalis Pharmaceuticals Inc. | Sandalwood oil and its uses related to skin disorders |
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2013
- 2013-10-07 CN CN201310459069.6A patent/CN103494940B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1169311A (en) * | 1996-06-24 | 1998-01-07 | 张宝力 | Preparation for diminishing freckle and use method thereof |
| CN101147763A (en) * | 2006-09-18 | 2008-03-26 | 张爱平 | Orally-administered medicine for treating chloasma |
| CN101181524A (en) * | 2007-11-20 | 2008-05-21 | 孙远贵 | Chinese medicine medical ointment for curing exogenous injury taint and pyogenic infection as well as preparation method thereof |
| CN102342985A (en) * | 2010-07-28 | 2012-02-08 | 陈登 | Chinese medicinal prescription for treating chloasma |
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| Title |
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| 密陀僧在外治法中的应用;聂永丽;《中医外治杂志》;19961231(第1期);第26-27页，尤其第26页第2.2节 * |
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Effective date of registration: 20181105 Address after: 537200 Xishan Town, Guiping City, Guigang, the Guangxi Zhuang Autonomous Region, No. 122 Cheng Bei Road. Patentee after: GUIPING PRODUCTIVITY PROMOTION CENTER Address before: 542800 high tech Development Zone, Hezhou, the Guangxi Zhuang Autonomous Region, No. 1 Patentee before: HEZHOU SITONG INFORMATION TECHNOLOGY Co.,Ltd. |