CN103190887A - Scattered chaotic light tomography method - Google Patents
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- CN103190887A CN103190887A CN2013101068628A CN201310106862A CN103190887A CN 103190887 A CN103190887 A CN 103190887A CN 2013101068628 A CN2013101068628 A CN 2013101068628A CN 201310106862 A CN201310106862 A CN 201310106862A CN 103190887 A CN103190887 A CN 103190887A
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Abstract
A scattered chaotic light tomography method includes achieving 1mum ytterbium-doped chaotic fiber laser signals; transmitting reference light of chaotic light signals; transmitting scattered light of chaotic light signals; achieving correlation of two ways of chaotic light signals; obtaining point spread functions; obtaining the organizer optical information amount; and reconstructing organizer parameters and graphs. By means of the method, the chaotic light signals are applied to scattered light tomography, the problems of low accuracy, spatial resolution, quantization performance and the like of pseudo-random signals are solved, and detection of parameter characteristics of biological tissues is achieved, so that research work of chaotic laser in related disciplines such as biomedical imaging and biological tissue health detection in scientific research originality can be promoted.
Description
Technical field
The present invention relates to a kind of chromatography imaging method, particularly a kind of chaotic signal is applied in the optical tomography system, to realize biomedical imaging and biological tissue's health detection.
Background technology
Existing diffuse optical tomography technology utilizes the relative penetration depth of scattered light in tissue to realize the clinical diagnosis of 5-10cm organ level, use near infrared light to determine the distributed in three dimensions of optical parametric in the biological tissue to provide the noinvasive Function detection pattern based on the important biochemical component of organizer in the non-intruding mode.Because but it has advantages such as harmless, radiationless continuous monitoring, playing a significant role in clinical diagnose becomes the research focus of medical imaging mode.
For the scattered light tomography monitor at present comparatively mature technique be utilize the light scattering imaging system of ultrasonic guidance and at home and abroad be used for clinical trial (Xu Zhenhua, Wu Chen, Mao Ling, cypress advances, Huang Xuandong.Ultrasonic light scattering imaging system examination breast carcinoma of early stage, Chinese tumor, 20(12): 932-936,2011).Along with the continuous development of scattered light chromatography imaging technique, the new scattering imaging technique that is applied to biological tissue is also constantly studied and is occurred.The Sergio Fantini seminar of Tufts Univ USA proposes light-scattering chromatography (the Fridrik Larusson based on the ultraphotic spectrum, Sergio Fantini and Eric L. Miller.Parametric level set reconstruction methods for hyperspectral diffuse optical tomography. Biomed Optics Express, 3 (5): 1006 – 1024. 2012.).Canada thank the Yves B é rub é of Brock University-Lauziere seminar propose the fluorescence light-scattering chromatography (Yves B é rub é-Lauziere and Eric Lapointe. A time-domain non-contact fluorescence diffuse optical tomography scanner for small animal imaging. OSA Biomed. BTuD76 .2010.).In the peak of University Of Tianjin seminar time-resolved fluorescence light scattering imaging (Feng Gao is proposed, Limin Zhang, Huiyuan He et al. A self-normalized, full time-resolved scheme for fluorescence diffuse optical tomography .Proc. of SPIE Vol. 6850,68500N, 1-12,2008.).But these light scattering techniques based on different principle are to utilize ultrashort pulse as probe source.
Along with the development of biomedical imaging, the scattered light tomography is also constantly developed.But based on the scattered light chromatography of near-infrared ultrashort pulse, because the existence of ultra-short pulse source causes it aspect the measurement that utilizes point spread function and imaging, complex structure.Because the pulse width of ultrashort pulse is usually at ps(10
-12Second) magnitude, and present photodetection and oscillographic bandwidth can't satisfy the needs of impulse response, make to use to be very restricted.
The near-infrared continuous light realizes that as light source the scattered light chromatographic technique provides the approach of dealing with problems for solving the scattered light chromatographic technique.J. J. A. Marota adopted the continuous light source of 32 different wave lengths to realize the light-scattering chromatography imaging in 1999, and the hemoglobin of successful detection of biological tissue and deoxyhemoglobin concentration (A. M. Siegel J. J. A. Marota and D. A. BoasDesign and evaluation of a continuous-wave diffuse optical tomography system .Optics Express.4(8): 287-298,1999.), studied widely based on the scattered light chromatography of continuous light since then.2003, Hamid Dehghani adopts multi wave length illuminating source to be used for light-scattering chromatography commercial measurement result and common ultrasound detection compares (Hamid Dehghani, Brian W. Pogue, Steven P. Poplack, and Keith D. Paulsen. Multiwavelength three-dimensional near-infrared tomography of the breast:initial simulation, phantom, and clinical results.Applied Optics, 42(1): 135-145,2003.), J. P. Culver utilizes continuous light to realize three-dimensional light-scattering chromatography (J. P. Culver, R. Choe, M. J. Holboke, L. Zubkov, T. Durduran, and A. Slemp V. Ntziachristos, B. Chance A. G. Yodh Three-dimensional diffuse optical tomography in the parallel plane transmission geometry:Evaluation of a hybrid frequency domain continuous wave clinical system for breast imaging. Medical. Physics. 30 (2): 235-246,2003.).But adopt the light scattering imaging of continuous wavelength low with respect to the light-scattering chromatography imaging signal to noise ratio based on ultrashort pulse, image quality is poor, and accuracy of detection is restricted.
Biological tissue is imaged in the medical treatment ﹠ health detection and plays a greater and greater role, survey the hemoglobin oxidation level of organizer by near infrared light, be used for human body under harmless, radiationless, safe situation, the imaging technique that presses for fine definition is realized health monitorings such as human body infantile tumour.
Yet traditional measuring method exists certainty of measurement to use with measurement and has the principle defective, and it is measured definition and has contradiction with the pulse width that adopts light source: improve certainty of measurement, just need to adopt ultrashort pulse.The pulse of ultrashort pulse is more narrow, and accuracy of detection is more high, and system is more complicated.If adopt ultrashort pulse to improve precision, then the Detection Techniques of ultrashort pulse generating technique and faint optical signal will increase the complexity of system greatly, and operation easier and cost are difficult to practicability and miniaturization.
The pseudo noise code method of correlation can solve the problem that continuous light is scattering into certainty of measurement and detecting limitation in the picture.Nan Guang Chen seminar exported pseudorandom pulse train by the acousto-optic modulation semiconductor laser that adopts pseudo noise code in 2003, and be used for the research of scattered light chromatography, realized that point spread function is resolution (the 9. Nan Guang Chen and Quing Zhu Time-resolved diffusive optical imaging using of 0.6ns
Pseudo-random bit sequences. Optics Express. 11 (25); 3445-3544,2003.), effort by seminar, adopted the modulation of 10GHz pseudo noise code to realize resolution (the 10. Qiang Zhang and Nan Guang Chen.Pseudo-random single photon counting:the principle of 200ps in 2009, simulation, and experimental results .Proc. of SPIE Vol. 7170 71700L-1,2009.).Weirong Mo proposed improved scattered light chromatography based on pseudo noise code (11. Weirong Mo on this basis in 2010, and Nanguang Chen. Design of an Advanced Time-Domain Diffuse Optical Tomography System.IEEE Journal of Selected Topics In Quantum Electronics, 16(3): 581-587,2010.).The corresponding patent of having delivered has DIFFUSE OPTICAL TOMOGRAPHY (US20080528146), SCATTER ATTENUATION TOMOGRAPHY (WO2007US76497), IMAGE RECONSTRUCTION METHOD FOR DIFFUSE OPTICAL TOMOGRAPHY, DIFFUSE OPTICAL TOMOGRAPHY SYSTEM, AND COMPUTER PROGEAM (US20100755965), DIFFUSE OPTICAL TOMOGRAPHY SYSTEM AND METHOD FOR USE (US20080050733), DETECTION OF STROKE EVENTS USING DIFFUSE OPTICAL TOMOGRAPHY (US2000491595).But at present mainly there is following several problem in the research based on the scattered light tomography of pseudo-random signal:
(1) fail to adopt effective validation criteria that the accuracy of constructed forward model based on radiation in the pseudo-random signal and transmission equation is verified;
(2) in the two-dimensional radiation transmission equation processing of photon scattering having been run counter to the physics law of photon spread;
(3) fail to solve and find the solution that used ideal boundary condition and actual physics situation difference cause the inaccurate problem of forward model in the radiation transfer equation;
(4) algorithm of inverse problem is verified that the data that adopt are the data that forward model own generates,
Namely to be solved to " the deceitful problem " of inverse problem.
And can pass through to increase the resolution that code length improves measuring system for the pseudo-random pulse sequence, but the generation of pseudorandom light pulse sequence need be by electric random code modulated laser.Be subjected to the restriction of electronic device bandwidth bottleneck, make that spatial resolution based on the scattered light tomographic system of pseudo-random signal is low and quantize the low phenomenon of performance not be improved significantly.
Summary of the invention
The concrete technical problem that the present invention will solve is based on the accuracy problem that exists in the radiation of pseudo-random signal and the transmission equation, realizes the research of the scattering tomography chromatography imaging method of high accuracy, high spatial resolution.Deficiency at above-mentioned prior art exists the invention provides a kind of scattering chaos photosphere and analyses formation method, and its concrete technical scheme is as follows:
Realize that 1 μ m mixes ytterbium chaos optical fiber laser signal;
Realize the transmission of the reference light of chaos optical signal;
Realize the transmission of the scattered light of chaos optical signal;
Realize the relevant of two paths chaos optical signals;
Realize obtaining of point spread function;
Realize obtaining of organizer optical information amount;
Realize the reconstruction of organizer parameter and the reconstruction of figure.
In technique scheme, further, additional technical feature is:
Described reference light is that 1 μ m is mixed ytterbium chaos optical fiber laser generation signal successively by variable delay device, photodetector and correlator and after scattered light is relevant, enters imaging system.
Described scattered light is that 1 μ m mixes ytterbium chaos optical fiber laser and produces signal and penetrate measurand successively by photodetector, amplifier and correlator and after reference light is relevant, enters imaging system.
It is successively by wavelength division multiplexer, Yb dosed optical fiber, highly nonlinear optical fiber, optoisolator, fiber grating, Polarization Controller and output coupler output chaos optical signal with the 980nm pumping source that described 1 μ m mixes ytterbium chaos optical fiber laser.
The device of described tomography is 1 μ m to be mixed the chaos optical signal that ytterbium chaos optical fiber laser produces be divided into two-way, one the tunnel as reference light, its reference light be 1 μ m mix chaos optical signal that ytterbium chaos optical fiber laser produces by variable delay device, photodetector and correlator with after scattered light is relevant, import data acquisition unit and imaging system; Another road is as scattered light, its scattered light be 1 μ m mix chaos optical signal that ytterbium chaos optical fiber laser produces by intensity modulator, sample module, photodetector, amplifier and correlator with after reference light is relevant, import data acquisition unit and imaging system.
The a kind of of the above-mentioned proposition of the present invention mixes the 1 μ m chaos optical signal that ytterbium chaos optical fiber laser produces, and this chaos optical signal is applied to scattered light tomography scheme.This scheme adopts fiber grating, utilizes fiber nonlinear effect, realizes that in erbium doped fiber laser wavelength is the near-infrared wavelength broadband chaos fiber optic laser source of 1 μ m.Utilize optical fiber to have good beam quality, and can be divided into different measurement passages as required, 1 μ m chaos optical signal as surveying light, is input in biological tissue's body, realize the detection to the parameter attribute of biological tissue.
For the detection of scattered light chromatography, adopt the relevant characteristic with the pulse of good δ type of chaotic signal.Its feature is relevant with the bandwidth of chaos, bandwidth is more wide, the pulse of δ type is more narrow, the shape of its shape and ultrashort pulse is similar, see through each position optical information amount in the point spread function curve of organizer by measuring δ type correlation function, the parameter characteristic that can draw biological tissue's body distributes, and realizes the detection to the hemoglobin oxidation level of organizer, thereby judges the health status of biological tissue.The present invention utilizes the characteristic of chaos δ type correlation function, and the time that solved is gone up the contradiction of ultrashort pulse detection of complex and certainty of measurement existence, realizes the scattered light chromatography of high measurement accuracy by the good dependency of broadband chaos.
The present invention is above-mentioned provide a kind of the chaos optical signal is applied to device and the chromatography imaging method thereof of scattered light tomography, compare with technology formerly, the advantage and the good effect that have are:
The present invention proposes in a kind of device that the chaos optical signal is applied to the scattered light tomography, solved problems such as pseudo-random signal low precision, low spatial resolution and quantification performance, realized monitoring scheme and the detection method of scattered light chromatography.
The present invention utilizes the chaos optical signal that good δ type pulse correlation characteristic is arranged, and has realized the obtaining of point spread function of little error, and especially obtaining of the little error of point spread function full width at half maximum and ideal point spread function full width at half maximum improved certainty of measurement.
To the randomness of high sensitivity and the chaos optical signal of boundary condition, realized the collection of the optical information amount of diverse location low error rate when the present invention utilizes the chaos optical signal to rebuild, thereby realized high measurement accuracy and quantized the image reconstruction of performance.
The present invention adopts the chaos method of correlation with the detection of chaos optical signal for the scattered light laminated imaging device, can be obtained from optical information parameter abundant in the correlation function.The enforcement of the technical program will promote chaotic laser light aspect the biomedical imaging and related discipline such as biological tissue's health detection original research work in scientific research.
Description of drawings
Fig. 1 is chromatography imaging method block diagram of the present invention.
Fig. 2 is chaotic signal generator structural representation of the present invention.
Fig. 3 is the structural representation that the present invention is used for Fig. 1 laminated imaging device.
Among the figure: 1:1 μ m mixes ytterbium chaos optical fiber laser; 2: variable delay device; 3: photodetector; 4: amplifier: 5: correlator; 6: imaging system.
Among the figure: the 7:980nm pumping source; 8: wavelength division multiplexer; 9: Yb dosed optical fiber; 10: highly nonlinear optical fiber; 11: optoisolator; 12: fiber grating; 13: Polarization Controller; 14: output coupler.
Among the figure: 1:1 μ m mixes ytterbium chaos optical fiber laser; 15: intensity modulator; 2: variable delay device; 5: correlator; 3: photodetector; 16: the sample module; 4: amplifier; 17: data acquisition unit; 6: imaging system.
The specific embodiment
Below the specific embodiment of the present invention is made further instruction.
As described in Figure 1, implement a kind of scattering chaos photosphere provided by the present invention and analyse imaging device, this device is that the generator that the chaos optical signal is applied to chaos optical signal in the scattered light tomography is comprised 980nm pumping source 7, wavelength division multiplexer 8, Yb dosed optical fiber 9, highly nonlinear optical fiber 10, optoisolator 11, fiber grating 12, Polarization Controller 13 and output coupler 14.
The described chaos optical signal of the technical scheme of the above-mentioned method for generation of the present invention is to utilize the nonlinear effect of optical fiber to realize.980nm laser is as the pumping source of Yb dosed optical fiber, and highly nonlinear optical fiber is used for by the generation of the nonlinear effect realization broadband chaos of optical fiber, and optoisolator guarantees the unidirectional running of fiber optic loop, and fiber grating is used for realizing the adjusting of wavelength and stablizing.Polarization Controller, optoisolator and Transmission Fibers are formed annular chamber, and employing 980nm/1000nm wavelength division multiplexer is pumped in the ytterbium-doping optical fiber laser 980nm's, by the adjusting of Polarization Controller and pumping current, realize the chaotic laser light output of Yb dosed optical fiber.
The present invention relates to the chaos optical signal is applied to the scattered light laminated imaging device, comprise that 1 μ m mixes ytterbium chaos optical fiber laser, intensity modulator, variable delay device, correlator, photodetector, organizes module, data acquisition unit and imaging system.
The described optical-fiber laser chaos source that the chaos optical signal is applied to the scattered light laminated imaging device of the technical scheme of the above-mentioned method for generation of the present invention is to satisfy therapeutic treatment window 600nm-1300nm wave band to realize that the degree of depth penetrates detection.Described intensity modulator is modulated into chaotic signal intensity controlled.Described sample module is that the parameters that meets human skin tissue and tumor is simulated, and generally can use lipomul and plastic absorber.Described detectable signal is the chaos optical signal by the sample module.Described photodetector is realized the conversion of photosignal, is used for the measurement of knub position.Described correlator is realized the cross-correlation of reference signal and detectable signal, is obtained from the optical information of correlation function and each position, thereby rebuilds knub position.
The application of chaos optical signal is in scattered light tomography checkout gear and method thereof, its formation is that 1 μ m mixes ytterbium chaos optical fiber laser 1 generation chaos optical signals intensity modulator 15 and modulates controlled, enter sample module 16 and realize optical detection, optical signal after the decay that detects carries out opto-electronic conversion and preserves image data at photodetector 3, after amplifying by amplifier 4, the detectable signal that collects in correlator 5, carries out cross-correlation with the chaos optical signal by the reference signal that variable delay device 2 realizations postpone, the point spread function curve is collected and be superimposed as to coherent signal by data acquisition unit 17, each position data input imaging system 6 realizes the inverting of inverse problem algorithm on the spread function curve of collection point, realize obtaining of organizer module reconstruction absorptance distribution, thus simulation knub position image.
This experiment measuring principle: the mathematical model that a kind of simulated light is propagated is set up in this experiment in organizer, thereby obtains the estimated value of surface measurement amount, i.e. forward model; Then, the measuring amount that obtains according to forward model and actual measuring system is carried out match to the optical parametric of organizer inside, thereby obtains the topological diagram picture of internal optics parameter, i.e. inverse problem.This experiment is based on the diffusion equation in the radiation transfer theory, utilizes Element BEM to set up corresponding forward mathematical model, and realizes the algorithm to diffuse optical tomography.1 μ m mixes the chaotic signal that ytterbium chaos optical fiber laser 1 produces and is divided into the transmission of two paths, and one the tunnel as the reference signal, by variable delay device 2 transmission, supposes that its output satisfies functional relation h (t); Another road by sample module 16, utilizes photodetector 3 to convert signal of telecommunication transmission to as detectable signal, supposes that it is f (t) that functional relation is satisfied in its output.Its cross-correlation function then
Based on this principle, collect the different period cross-correlated signal that postpone by data acquisition unit 17 and be superimposed as point spread function.The discrete vertical mark method of employings such as Klose and finite difference method are found the solution radiation transfer equation, and under equilibrium mode, adopt gradient method that image is rebuild, Jing Meng etc. adopts the method for gradient tree that image is rebuild on this basis, Kui Ren etc. has adopted Finite Element Method to find the solution to radiation transfer equation under frequency mode, and adopts the Gauss-Newton method to carry out image reconstruction.Employing minimum variance Finite Element Methods such as O.Balima have been found the solution the frequency domain radiation transfer equation.Hyun Keol Kim has developed and adopts the gradient method that need not to carry out linear search to carry out the algorithm of image reconstruction under the frequency domain pattern.Tanja Tarvainen etc. has set up the forward model of associating radiation transfer equation and diffusion equation.E.D.Aydin adopts the humorous wave method of finite element-ball to find the solution radiation transfer equation.Thus, under diffusion equation and boundary condition situation, utilize the MATLAB program, can realize the detection of female mammary gland knub position.
Claims (5)
1. a scattering chaos photosphere is analysed formation method, comprises the chaos method of correlation; The implementation method of its described tomography is as follows:
Realize that 1 μ m mixes ytterbium chaos optical fiber laser signal;
Realize the transmission of the reference light of chaos optical signal;
Realize the transmission of the scattered light of chaos optical signal;
Realize the relevant of two paths chaos optical signals;
Realize obtaining of point spread function;
Realize obtaining of organizer optical information amount;
Realize the reconstruction of organizer parameter and the reconstruction of figure.
2. scattering chaos photosphere as claimed in claim 1 is analysed formation method, its described reference light is that 1 μ m is mixed ytterbium chaos optical fiber laser (1) generation signal successively by variable delay device (2), photodetector (3) and correlator (5) and after scattered light is relevant, enters imaging system (6).
3. scattering chaos photosphere as claimed in claim 1 is analysed formation method, its described scattered light is that 1 μ m mixes ytterbium chaos optical fiber laser (1) and produces signal and penetrate measurand (16) successively by photodetector (3), amplifier (4) and correlator (5) and after reference light is relevant, enters imaging system (6).
4. scattering chaos photosphere as claimed in claim 1 is analysed formation method, and it is successively by wavelength division multiplexer (8), Yb dosed optical fiber (9), highly nonlinear optical fiber (10), optoisolator (11), fiber grating (12), Polarization Controller (13) and output coupler (14) output chaos optical signal with 980nm pumping source (7) that its described 1 μ m mixes ytterbium chaos optical fiber laser (1).
5. scattering chaos photosphere as claimed in claim 1 is analysed formation method, the device of its described tomography is 1 μ m to be mixed the chaos optical signal that ytterbium chaos optical fiber laser (1) produces be divided into two-way, one the tunnel as reference light, its reference light is that 1 μ m mixes chaos optical signal that ytterbium chaos optical fiber laser (1) produces by variable delay device (2), photodetector (3) and correlator (5) and after scattered light is relevant, imports data acquisition unit (17) and imaging system (6); Another road is as scattered light, its scattered light is that 1 μ m mixes chaos optical signal that ytterbium chaos optical fiber laser (1) produces by intensity modulator (15), sample module (16), photodetector (3), amplifier (4) and correlator (5) and after reference light is relevant, imports data acquisition unit (17) and imaging system (6).
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| CN113258420A (en) * | 2021-05-06 | 2021-08-13 | 太原理工大学 | Chaotic laser device and method based on ytterbium-doped fiber laser |
| CN113484281A (en) * | 2021-05-28 | 2021-10-08 | 太原理工大学 | Optical encryption device and method based on unique light scattering characteristics of biological tissues |
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Application publication date: 20130710 |