CN103163268A - Medical breath testing device and testing method thereof - Google Patents
Medical breath testing device and testing method thereof Download PDFInfo
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- CN103163268A CN103163268A CN2013100923197A CN201310092319A CN103163268A CN 103163268 A CN103163268 A CN 103163268A CN 2013100923197 A CN2013100923197 A CN 2013100923197A CN 201310092319 A CN201310092319 A CN 201310092319A CN 103163268 A CN103163268 A CN 103163268A
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Abstract
The invention discloses a medical breath testing device which has the advantages of low testing cost, simple process, short time, accurate result and wide application. The device comprises a sample introduction port, a sampling pump, a six-way valve, a gas carrying cylinder, an adsorption tube, a chromatographic column, a surface acoustic wave detector and a data process system, wherein the six-way valve is respectively connected with the sample introduction port, the gas carrying cylinder, a first end of the adsorption tube, a second end of the adsorption tube, the sampling pump and one end of the chromatographic column; the other end of the chromatographic column is connected with the surface acoustic wave detector, the output end of which accesses into the data process system. The invention further discloses a testing method utilizing the device.
Description
Technical field
The invention belongs to the technical field of medicine equipment, relate in particular to a kind of medical breath detection device, also relate to the detection method of using this medical breath detection device.
Background technology
The uncommon ripple of ancient Greek undercuts the epoch, and doctors come the auxiliary diagnosis disease with regard to knowing the smell by detecting patient exhales.In the France in 18th century, the pioneer of Antoine Lavoisier-modern chemical analysis, he is that first analyzes expiration, proves that it contains carbon dioxide.Modern breath tester starts from 1971, and Nobel chemistry Prize winner Linus ripple woods finds that the normal concentration that comprises many different volatile organic compounds of exhaling of the mankind is very low.But, these technology are just used by indivedual experts at present, also be not widely applied in medical practice, this is because the organism kinds in detect exhaling and the variation of quantity can only manually be completed by experienced expert, so just makes that this expiration testing cost is high, process is complicated, the time is very long, out of true as a result.
Summary of the invention
The technical problem to be solved in the present invention is to provide that a kind of testing cost is lower, process is simple, the time is short, result is accurate, widely used medical breath detection device.
The technical scheme that addresses the above problem is: this medical breath detection device, it comprises injection port, sampling pump, six-way valve, carrier gas bottle, adsorption tube, chromatographic column, surface acoustic wave detecting device, data handling system, six-way valve connects respectively the second end, the sampling pump of first end, the adsorption tube of injection port, carrier gas bottle, adsorption tube, an end of chromatographic column, the other end connecting surface sound wave detector of chromatographic column, the output terminal access data disposal system of surface acoustic wave detecting device.
A kind of detection method of using this medical breath detection device also is provided, has comprised the following steps:
(1) sample phase: six-way valve switches to sample states, injection port connects the first end of adsorption tube, adopts pump to connect the second end of adsorption tube, and carrier gas bottle connects chromatographic column, the expiration sample is inhaled into injection port by sampling pump, enters adsorption tube and is adsorbed at this via six-way valve;
(2) analysis phase: six-way valve switches to analysis state, injection port connects sampling pump, and carrier gas bottle connects the first end of adsorption tube, and the second end of adsorption tube connects chromatographic column, the adsorption tube heating, the sample desorption is brought into chromatographic column and separates by the carrier gas in carrier gas bottle, and after separating, different materials can flow out from chromatographic column successively, then arrive the surface acoustic wave detecting device, the surface acoustic wave detecting device detects frequency change, records these variations, obtains chromatogram after data-switching;
(3) data the processing stage: utilize data handling system that chromatogram is processed, and the significant compound in chromatogram is carried out pattern recognition process, thereby obtain comparing result.
When adopting this medical breath detection device and detection method thereof, just need not artificial judgment, so testing cost is lower, process is simple, the time is short, result is accurate, be widely used.
Description of drawings
Structural representation when Fig. 1 is preferred embodiment sampling of medical breath detection device of the present invention;
Fig. 2 is the structural representation of preferred embodiment of medical breath detection device of the present invention when analyzing;
Fig. 3 a, 3b are respectively the normal person's that obtains of detection method of the present invention testing result and its finger-prints;
Fig. 4 a, 4b are respectively the normal person's that obtains of detection method of the present invention testing result and its finger-prints;
Fig. 5 is the process flow diagram of a preferred embodiment of detection method of the present invention.
Embodiment
We know now, and sample normal person's expiration usually comprises and surpasses 200 different volatile organic compounds, and wherein great majority are in picomole (Pico molar) concentration.The kind of these compounds and content, metabolic closely bound up with in body.When in body, the appearance of part organ is abnormal (pathology), the variation that will produce novel compound or existing compound generating capacity in body.Detect these organism kinds in exhaling and the variation of amount, according to the way of artificial neural network isotype identification, we can make diagnosis to disease (such as rejecting in lung cancer, pulmonary tuberculosis, breast cancer, organ transplant body etc.).
Take lung cancer as example.
Lung cancer is one of modal malignant tumour in the world at present, accounts for 16% of whole malignant tumours, 28% of mortality of malignant tumors.At present, only 14.1%, 60% patient is dead in rear 1 year of diagnosis for 5 years survival rates of patient diagnosed.The means such as the triage techniques of tradition lung cancer such as x-ray, phlegm inspection, Bronchofiberscope can not reduce screened crowd's lung cancer mortality.Testing process is comparatively loaded down with trivial details, and the time is longer, dynamic monitoring in early days and being restricted.The advanced technologies such as new technology such as spiral CT, positron emission imaging, molecule damage check technology be applied to the lung cancer early diagnosis and by stages, dynamic monitoring state of an illness aspect obtains certain progress.But because of its somewhat expensive, methodology complexity, technical requirement is high, is difficult at present as conventional lung cancer early diagnosis and dynamic monitoring means.
As shown in Fig. 1-2, applicant's this medical breath detection device, it comprises injection port 1, sampling pump 5, six-way valve 2, carrier gas bottle 3, adsorption tube 4, chromatographic column 6, surface acoustic wave detecting device 7, data handling system 8, six-way valve connects respectively the second end, the sampling pump of first end, the adsorption tube of injection port, carrier gas bottle, adsorption tube, an end of chromatographic column, the other end connecting surface sound wave detector of chromatographic column, the output terminal access data disposal system of surface acoustic wave detecting device.
Preferably, described carrier gas bottle 3 is inert gas carrier gas bottles, such as helium tank, nitrogen cylinder, argon bottle etc.
Preferably, described surface acoustic wave detecting device 7 comprises mode of resonance surface acoustic wave component, piezoelectric crystal plate, semiconductor temperature assembly.
Preferably, described data handling system 8 is computing machines.
Preferably, this pick-up unit also comprises attemperating unit (not shown in Fig. 1-2), and attemperating unit connects respectively injection port, six-way valve, adsorption tube, chromatographic column, surface acoustic wave detecting device, in order to control respectively the temperature of these parts.
A kind of detection method of using this medical breath detection device also is provided, has comprised the following steps:
(1) sample phase: six-way valve switches to sample states (as Fig. 1), injection port connects the first end of adsorption tube, adopts pump to connect the second end of adsorption tube, and carrier gas bottle connects chromatographic column, the expiration sample is inhaled into injection port by sampling pump, enters adsorption tube and is adsorbed at this via six-way valve;
(2) analysis phase: six-way valve switches to analysis state (as Fig. 2), injection port connects sampling pump, and carrier gas bottle connects the first end of adsorption tube, and the second end of adsorption tube connects chromatographic column, the adsorption tube heating, the sample desorption is brought into chromatographic column and separates by the carrier gas in carrier gas bottle, and after separating, different materials can flow out from chromatographic column successively, then arrive the surface acoustic wave detecting device, the surface acoustic wave detecting device detects frequency change, records these variations, obtains chromatogram after data-switching;
(3) data the processing stage: utilize data handling system that chromatogram is processed, and the significant compound in chromatogram carried out pattern recognition process, thereby obtain comparing result (Fig. 3 a, 3b, 4a, 4b have provided the example of the comparing result of a normal person and lung cancer).
Take lung cancer detection as example
Treat examination personnel's expiration with the airbag collection, utilize the application's device to carry out sampling and analyzing, treat the examination personnel and make diagnosis.
In Fig. 3, one is normal personnel's breath tester analysis, and another is the breath tester analysis of patients with lung cancer.There is larger difference in two experimental results, and its finger-print can obviously be distinguished, thereby can make diagnosis to normal person person and patients with lung cancer.
Preferably, pattern recognition process adopts Artificial Neural Network.Can also carry out fingerprint map analyzing.
Certainly, detection method of the present invention also can be carried out according to the flow process of Fig. 5.
When adopting this medical breath detection device and detection method thereof, just need not artificial judgment, so testing cost is lower, process is simple, the time is short, result is accurate, be widely used.
The above; it is only preferred embodiment of the present invention; be not that the present invention is done any pro forma restriction, every foundation technical spirit of the present invention all still belongs to the protection domain of technical solution of the present invention to any simple modification, equivalent variations and modification that above embodiment does.
Claims (7)
1. medical breath detection device, it is characterized in that: it comprises injection port (1), sampling pump (5), six-way valve (2), carrier gas bottle (3), adsorption tube (4), chromatographic column (6), surface acoustic wave detecting device (7), data handling system (8), six-way valve (2) connects respectively injection port (1), carrier gas bottle (3), the first end of adsorption tube (4), the second end of adsorption tube (4), sampling pump (5), one end of chromatographic column (6), the other end connecting surface sound wave detector (7) of chromatographic column (6), the output terminal access data disposal system (8) of surface acoustic wave detecting device.
2. medical breath detection device according to claim 1, it is characterized in that: described carrier gas bottle (3) is the inert gas carrier gas bottle.
3. medical breath detection device according to claim 1 and 2, it is characterized in that: described surface acoustic wave detecting device (7) comprises mode of resonance surface acoustic wave component, piezoelectric crystal plate, semiconductor temperature assembly.
4. medical breath detection device according to claim 3, it is characterized in that: described data handling system (8) is computing machine.
5. medical breath detection device according to claim 1, it is characterized in that: this pick-up unit also comprises attemperating unit, attemperating unit connects respectively injection port, six-way valve, adsorption tube, chromatographic column, surface acoustic wave detecting device, in order to control respectively the temperature of these parts.
6. detection method of using medical breath detection device according to claim 1 is characterized in that: comprise the following steps:
(1) sample phase: six-way valve switches to sample states, injection port connects the first end of adsorption tube, adopts pump to connect the second end of adsorption tube, and carrier gas bottle connects chromatographic column, the expiration sample is inhaled into injection port by sampling pump, enters adsorption tube and is adsorbed at this via six-way valve;
(2) analysis phase: six-way valve switches to analysis state, injection port connects sampling pump, and carrier gas bottle connects the first end of adsorption tube, and the second end of adsorption tube connects chromatographic column, the adsorption tube heating, the sample desorption is brought into chromatographic column and separates by the carrier gas in carrier gas bottle, and after separating, different materials can flow out from chromatographic column successively, then arrive the surface acoustic wave detecting device, the surface acoustic wave detecting device detects frequency change, records these variations, obtains chromatogram after data-switching;
(3) data the processing stage: utilize data handling system that chromatogram is processed, and the significant compound in chromatogram is carried out pattern recognition process, thereby obtain comparing result.
7. detection method according to claim 6, is characterized in that: pattern recognition process employing Artificial Neural Network.
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| CN106770811A (en) * | 2016-11-10 | 2017-05-31 | 中国科学院声学研究所 | A kind of method and apparatus for detecting drugs content in expiration |
| CN107041751A (en) * | 2017-04-01 | 2017-08-15 | 浙江大学 | A kind of surface acoustic wave sensor of breathing state detecting system and wireless and passive |
| CN108845054A (en) * | 2018-07-12 | 2018-11-20 | 同方威视技术股份有限公司 | Item detection systems and method, electronic equipment, storage medium |
| CN114509527A (en) * | 2022-02-15 | 2022-05-17 | 西安交通大学 | Separation detection method, system and application of human body respiration sign VOCs gas |
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Application publication date: 20130619 |