CN103110420A - Magnetic resonance angiography method and magnetic resonance angiography system - Google Patents
Magnetic resonance angiography method and magnetic resonance angiography system Download PDFInfo
- Publication number
- CN103110420A CN103110420A CN2013100387664A CN201310038766A CN103110420A CN 103110420 A CN103110420 A CN 103110420A CN 2013100387664 A CN2013100387664 A CN 2013100387664A CN 201310038766 A CN201310038766 A CN 201310038766A CN 103110420 A CN103110420 A CN 103110420A
- Authority
- CN
- China
- Prior art keywords
- phase
- blood
- gradient
- magnetic field
- loose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Magnetic Resonance Imaging Apparatus (AREA)
Abstract
The invention discloses a magnetic resonance angiography method. The magnetic resonance angiography method includes applying a flowing sensitive dispersed phase gradient magnetic field in the readout direction and/or the phase encoding direction and/or the layer selection direction in a vasoconstriction period and then applying a residual magnetic moment removing gradient magnetic field after the flowing sensitive dispersed phase gradient magnetic field is applied; collecting blood flow images in the vasoconstriction period; collecting blood flow images in a vasodilatation period; and carrying out subtraction on the blood flow images in the vasoconstriction period and the blood flow images in the vasodilatation period to obtain blood flow images. The invention further discloses a magnetic resonance angiography system. According to the magnetic resonance angiography method and the magnetic resonance angiography system, in the specific implementation method, the flowing sensitive dispersed phase is used in the vasoconstriction period imaging process, so that intra-arterial self-spin dispersed phase can significantly lower arterial blood signals, and therefore the influence on imaging due to the velocity and the direction of blood flow can be reduced, high-quality peripheral arterial images can be obtained, and clinical practicability of the non-enhanced magnetic resonance angiography technology is improved.
Description
Technical field
The application relates to medical imaging, relates in particular to a kind of Magnetic Resonance Angiography method and system.
Background technology
Magnetic resonance angiography (Magnetic Resonance Angiography, MRA) is one of Main Means of present clinical diagnosis vascular lesion, and it generally includes Enhanced MRA and two kinds of methods of non-Enhanced MRA.
Enhanced MRA refers to inject contrast agent (containing the gadolinium paramagnetic contrast agent) in blood vessel after, then carry out the method for blood vessel imaging.Think that in the past the side effect that contains gadolinium class paramagnetic contrast agent is very little, human body is not constituted a threat to.But in the recent period a large amount of research datas shows, this class contrast agent has potential infringement to renal function, and especially the patient of renal insufficiency can cause a kind of fatal complication, is called kidney source property system fiber.In addition, Enhanced MRA is at peripheral blood vessel, especially the tremulous pulse of hand and foot, clinical application effect is unsatisfactory, and main cause is that the endarterial blood flow of periphery end is slower, easily is subjected to " pollution " of vein image during development, in addition, contrast agent is very short in the time of intra-arterial first passage, has limited the spatial resolution of image acquisition, and the tiny tremulous pulse that shows hand and foot is had certain difficulty.But not Enhanced MRA is to utilize special mr imaging technique, in the situation that do not need contrast agent to show the method for blood vessel.Not only can avoid the severe complication that causes because of contrast agent, and can extend sweep time, increase spatial resolution.Yet existing method is very easy to be subjected to the impact of blood flow rate and direction, to showing that traveling is tortuous, hand and Foot arteries that caliber is tiny have very large difficulty.
Summary of the invention
The technical problem that the application will solve is for the deficiencies in the prior art, and a kind of Magnetic Resonance Angiography method that can overcome blood flow rate and aspect effect is provided.
Another technical problem that the application will solve is to provide a kind of Magnetic Resonance Angiography system.
The technical problem that the application will solve is solved by the following technical programs:
A kind of Magnetic Resonance Angiography method comprises:
Within the vasoconstriction phase, apply the loose phase gradient of Flow sensitive magnetic field reading direction and/or phase-encoding direction and/or a choosing layer direction, at the gradient magnetic of the loose remaining magnetic moment of the after-applied removing in phase gradient magnetic field of described Flow sensitive;
Gather the blood-stream image in the vasoconstriction phase;
Gather the blood-stream image in the vasodilation phase;
Blood-stream image in described systole and the blood-stream image in relaxing period are subtracted shadow acquisition blood-stream image.
Described within the vasoconstriction phase, apply the loose phase gradient of Flow sensitive magnetic field reading direction and/or phase-encoding direction and/or a choosing layer direction, the gradient magnetic at the loose remaining magnetic moment of the after-applied removing in phase gradient magnetic field of described Flow sensitive comprises:
In the paradoxical expansion that ecg-gating triggers, reading direction and/or phase-encoding direction and/or selecting a layer direction to apply 90 °
x-180 °
y-90 °
-xRf pulse sequence and asymmetrical load are at 180 °
yThe loose phase gradient of the Flow sensitive on pulse both sides magnetic field applies in described pulse train back the gradient magnetic of removing remaining magnetic moment.
The first moment m in the loose phase gradient of described Flow sensitive magnetic field
1Satisfy
Minimum, wherein φ is the resultant spin phase place, γ is the gyromagnetic ratio constant,
It is the flowing velocity of i spin.
Blood-stream image in the described collection vasoconstriction phase comprises:
Balance steady state free precession technology gathers the blood-stream image in the vasoconstriction phase.
Blood-stream image in the described collection vasodilation phase comprises:
In the diastole that ecg-gating triggers, apply 90 °
x-180 °
y-90 °
-xRf pulse sequence;
Balance steady state free precession technology gathers the blood-stream image in the vasodilation phase.
A kind of Magnetic Resonance Angiography system comprises systole image capture module, relaxing period image capture module and subtracts the shadow module,
Described systole image capture module was used within the vasoconstriction phase, apply the loose phase gradient of Flow sensitive magnetic field reading direction and/or phase-encoding direction and/or a choosing layer direction, at the gradient magnetic of the loose remaining magnetic moment of the after-applied removing in phase gradient magnetic field of described Flow sensitive, gather the blood-stream image in the vasoconstriction phase;
Described relaxing period image capture module is used for gathering the blood-stream image in the vasodilation phase;
The described shadow module that subtracts is used for the blood-stream image in described systole and the blood-stream image in relaxing period are subtracted shadow acquisition blood-stream image.
Described systole image capture module comprises the FSD preparatory unit, is used in the paradoxical expansion that ecg-gating triggers, and is reading direction and/or phase-encoding direction and/or is selecting a layer direction to apply 90 °
x-180 °
y-90 °
-xRf pulse sequence and asymmetrical load are at 180 °
yThe loose phase gradient of the Flow sensitive on pulse both sides magnetic field applies in described pulse train back the gradient magnetic of removing remaining magnetic moment.
The first moment m in the loose phase gradient of described Flow sensitive magnetic field
1Satisfy
Minimum, wherein φ is the resultant spin phase place, γ is the gyromagnetic ratio constant,
It is the flowing velocity of i spin.
Described systole image capture module also is used for balance steady state free precession technology and gathers interior blood-stream image of vasoconstriction phase.
Described relaxing period image capture module also is used for applying 90 ° in the diastole that ecg-gating triggers
x-180 °
y-90 °
-xRf pulse sequence; Balance steady state free precession technology gathers the blood-stream image in the vasodilation phase.
Owing to having adopted above technical scheme, the beneficial effect that the present invention possesses is:
⑴ in the application's the specific embodiment, owing to adopting the loose phase of Flow sensitive in the systole imaging, make the loose phase of intra-arterial spin and cause arterial blood signal decrease, thereby can reduce blood flow rate and direction to the impact of imaging, obtain high-quality peripheral arterial image, improved the Clinical practicability of non-Contrast-enhanced MR angiography technology.
⑵ in the application's the specific embodiment, owing to applying the loose phase gradient of Flow sensitive magnetic field reading direction and/or phase-encoding direction and/or a choosing layer direction, can carry out one dimension, two dimension or the three-dimensional loose phase of Flow sensitive according to actual needs, further improve the adaptability that uses.
⑶ in the application's the specific embodiment, after applying the loose phase gradient of Flow sensitive magnetic field, apply again and remove remaining magnetic moment magnetic field gradient, the blood flow spin that has guaranteed the loose phase of last direction can be by the loose phase of gathering partially or completely mutually of a rear direction, thereby guaranteed that all directions press down the independence of blood effect, have further improved the effect of loose phase.
⑷ in the blood flow imaging of systole and relaxing period, adopt balance steady state free precession technology to carry out imaging in the application's the specific embodiment, and image taking speed is fast, signal to noise ratio is high, visual field reaches greatly and is not subjected to blood flow rate and aspect effect.
⑸ in the application's the specific embodiment, adopt the loose phase of Flow sensitive and balance steady state free precession technology, because its image taking speed is very fast, can be in same cardiac cycle, complete the blood flow imaging of systole and relaxing period, can reduce vessel position and change the registration mistake that causes, thereby improve picture quality.
Description of drawings
Fig. 1 is the flow chart of an embodiment of the application's Magnetic Resonance Angiography method;
Fig. 2 is the schematic diagram of another embodiment of the application's Magnetic Resonance Angiography method;
Fig. 3 is the flow chart of another embodiment of the application's Magnetic Resonance Angiography method;
Fig. 4 is the schematic diagram of another embodiment radio frequency sequence of the application's Magnetic Resonance Angiography method;
Fig. 5 is the schematic diagram that another embodiment of the application's Magnetic Resonance Angiography method gathers " black arterial blood " image radio frequency sequence;
Fig. 6 is the schematic diagram that another embodiment of the application's Magnetic Resonance Angiography method gathers " bright arterial blood " image radio frequency sequence;
Fig. 7 is the structural representation of an embodiment of the application's Magnetic Resonance Angiography system.
The specific embodiment
By reference to the accompanying drawings the present invention is described in further detail below by the specific embodiment.
In present non-Enhanced MRA technology, Fresh blood imaging technology (fresh blood imaging, FBI) basic sequence that adopts is the 3-dimensional fast spin echo of half fourier transform, under electrocardiograms, gathers respectively artery of lower extremity at diastole and Syst image.Tremulous pulse at relaxing period because blood flow rate presents high signal (the bright blood image of tremulous pulse) slowly, because blood flow rate presents low signal (tremulous pulse is deceived the blood image) soon, and vein slowly all shows as the high signal of strength similarity at relaxing period and systole because of blood flow rate at systole.Relaxing period and Syst image are subtracted shadow, namely obtain only having the blood-vessel image of artery of lower extremity.The advantage of the method is the entrance effect that blood flow signal does not rely on blood, thereby can be used for the long artery of lower extremity of stroke.Its shortcoming is that the tremulous pulse caliber is larger at relaxing period and Syst variation, may cause because of the registration mistake edge blurry of tremulous pulse image when subtracting shadow.Secondly, the loss of signal easily occurs when too fast or blood flow direction is disorderly in blood flow rate in spin echo, causes over-evaluating the angiostenosis degree.In addition, long imaging time has also limited the method application clinically.
The basic sequence that adopts based on the non-Enhanced MRA method of NATIVE-SPACE sequence is also spin echo, but it adopts the variable flip angle technology, before be enhanced on scanning speed and spatial resolution, at present the method does not have the imaging effect in the patient of remarkable pathological changes ideal at healthy volunteer or lower limb vascular, but artery of lower extremity there are the patient of Serious Stenosis and the tremulous pulse of hand and foot, its picture quality is still limited, and core reasons are that NATIVE-SPACE is more responsive to blood flow rate and direction ratio.
The radiography Enhanced MRA is not suitable for the patient of renal insufficiency, and produces easily that vein pollutes and image spatial resolution is low.And the non-Enhanced MRA technology of existing FBI and Native-SPACE all is based on spin echo, and is more responsive to blood flow rate and direction ratio, and dropout in the time of can causing the too fast or blood flow rate of blood flow rate disorderly causes over-evaluating the angiostenosis degree.The application proposes based on steady state free precession (steady-state free precession based on this defective, SSFP) with loose (the Flow-Sensitive Dephasing mutually of Flow sensitive, FSD) the non-Enhanced MRA method of technology, to obtain high-quality peripheral arterial image, improve the Clinical practicability of non-Enhanced MRA technology.
Fig. 1 illustrates the flow chart according to an embodiment of the application's Magnetic Resonance Angiography method, comprising:
Step 102: within the vasoconstriction phase, apply the loose phase gradient of Flow sensitive magnetic field reading direction and/or phase-encoding direction and/or a choosing layer direction, at the gradient magnetic of the loose remaining magnetic moment of the after-applied removing in phase gradient magnetic field of Flow sensitive;
Step 104: gather the blood-stream image in the vasoconstriction phase;
Step 106: gather the blood-stream image in the vasodilation phase;
Step 108: the blood-stream image in described systole and the blood-stream image in relaxing period are subtracted shadow acquisition blood-stream image.
A kind of embodiment, step 102 specifically comprises: in the paradoxical expansion that ecg-gating triggers, reading direction and/or phase-encoding direction and/or selecting a layer direction to apply 90 °
x-180 °
y-90 °
-xRf pulse sequence and asymmetrical load are at 180 °
yThe loose phase gradient of the Flow sensitive on pulse both sides magnetic field applies in the pulse train back gradient magnetic of removing remaining magnetic moment.
A kind of embodiment, the first moment m in the loose phase gradient of Flow sensitive magnetic field
1Satisfy
Minimum, wherein φ is the resultant spin phase place, γ is the gyromagnetic ratio constant,
It is the flowing velocity of i spin.
A kind of embodiment, step 104 specifically comprises:
Steps A 01: use spectral selection fat saturation technique to carry out fat suppression;
Steps A 02: use the linear preparation radio-frequency pulse that increases of 10 flip angles;
Steps A 03: balance steady state free precession technology gathers the blood-stream image in the vasoconstriction phase.
A kind of embodiment, step 106 specifically comprises:
Step B01: in the diastole that ecg-gating triggers, apply 90 °
x-180 °
y-90 °
-xRf pulse sequence;
Step B02: use spectral selection fat saturation technique to carry out fat suppression;
Step B03: use the linear preparation radio-frequency pulse that increases of 10 flip angles;
Step B04: balance steady state free precession technology gathers the blood-stream image in the vasodilation phase.
Fig. 2 is the schematic diagram according to another embodiment of the application's Magnetic Resonance Angiography method, and wherein vertical coordinate is signal intensity, and 1 is tremulous pulse, 2 is vein, A1 is diastole " bright arterial blood " collection, and A2 is that " the black arterial blood " of paradoxical expansion gathers, and S is for subtracting shadow.
Two groups of data by ecg-gating triggering collection paradoxical expansion and relaxing period.In systole, the flow velocity of artery blood flow is significantly higher than venous blood flow, uses the FSD technology to make the intra-arterial spin mutually loose and cause arterial blood signal decrease, adopt image be called " black arterial blood " image; Here, spin is loose refers to that mutually each spin in a voxel has different phase values, and when such phase difference reached enough large degree, the overall signal of this voxel (vector integration) will trend towards zero.The spin of artery blood flow is loose to be caused by the responsive gradient magnetic of blood flow (being the FSD gradient magnetic) mutually, the first moment of this gradient magnetic (first-order gradient moment[m
1]) be to weigh it to the sensitivity of blood flow or to the inhibition ability of blood flow signal.In relaxing period, arteriovenous blood flow velocity difference not quite and comparatively slow, two vascular flows all keep highlighted signal, adopt image be called " bright arterial blood " image.The image amplitude of carrying out of this twice collection is subtracted shadow namely obtains clean background, arterial blood is the blood-vessel image of highlighted signal.The non-Enhanced MRA technology of the present embodiment is due to the entrance effect that does not rely on fresh blood and can carry out the Coronal collection and be more suitable for the slow and larger peripheral arterial imaging of scope of blood flow.
In A1, tremulous pulse and vein are all highlighted signals, in A2, the FSD technology makes the loose phase of intra-arterial spin and causes arterial blood signal decrease, the venous blood signal is slow and slightly reduced due to blood flow, therefore is retained and the venous blood signal almost completely disappears at final S subtraction image arterial blood signal.
Fig. 3 is according to the flow chart of another embodiment of the application's Magnetic Resonance Angiography method, comprising:
Step 302: ecg-gating triggers in paradoxical expansion;
Step 304:FSD prepares.FSD is used for suppressing the technology of blood flow signal in the imaging of MRI blood vessel wall, it is based on the responsive gradient of blood flow, and the phase place of moving spin in discrete fluid makes the blood flow loss signal.The remarkable characteristic of FSD is, it depends on magnetic field gradient first moment and blood flow rate to the inhibition ability of blood flow signal, as long as set the suitable m1 value of, just can utilize the difference of arteriovenous blood flow rate, when at utmost suppressing the artery blood flow signal, keep most the venous blood flow signal.FSD prepares one by 90 °
x-180 °
y-90 °
-xRf pulse sequence and asymmetrical load are at 180 °
yThe FSD gradient magnetic on pulse both sides and the gradient magnetic that is carried in the remaining magnetic moment of removing of pulse train back form, and as shown in Figure 4, wherein P represents radio-frequency pulse, G1 represents readout gradient, G2 represents phase encoding gradient, and G3 represents slice selective gradient, and S represents to remove the gradient magnetic of remaining magnetic moment.The spin of blood flow is loose to be caused by the FSD gradient magnetic mutually.At FSD gradient magnetic (vector)
Effect under, the phase place of a mobile spin, φ is determined by following formula:
Here γ is the gyromagnetic ratio constant,
It is the flowing velocity of this spin.For one with
Vertical blood flow, the phase place of each spin is 0, therefore do not have spin-spin phase difference, also just can not occur by the loose signal suppressing that causes mutually of spin, the blood flow spin is loose to be required mutually the blood flow that is applied along FSD gradient magnetic direction or has in the direction component at least.For aforementioned selected suitable m
1Value should be able to satisfy
Minimum, wherein φ is the resultant spin phase place, γ is the gyromagnetic ratio constant,
It is the flowing velocity of i spin.FSD magnetic field can be applied on 1 (for the one dimension blood flow) or 2 (for two-dimentional blood flow) or 3 (for three-dimensional blood flow) directions.People's blood vessel is different trends, the one dimension here refers to blood flow facing one direction, two dimension refers to the blood flow towards both direction, such as the blood flow that has on foot from the heel to the direction of toe of last, also has the blood flow from instep to the sole direction, three-dimensional refer to blood flow towards three directions, FSD magnetic field can tandem compound, and the FSD preparation module of each series connection is called the FSD submodule.In the present embodiment, the FSD gradient magnetic only is loaded in first submodule and reads direction, is loaded in phase-encoding direction in second submodule, be loaded in the 3rd submodule on choosing layer direction, and the submodule order can be changed.It should be appreciated by those skilled in the art that these three directions are exemplary, can be carried according to actual needs on three directions of any quadrature.Every submodule only suppresses the blood flow component signal on one of them orthogonal direction.The remaining magnetic moment magnetic field gradient of removing between submodule has guaranteed can not gathered partially or completely phase by the submodule of back by the blood flow spin of the loose phase of last submodule, thereby has guaranteed that each submodule presses down the independence of blood effect.After all submodule moved, the blood flow signal of all directions all can be effectively suppressed.
Step 306: fat suppression, use spectral selection fat saturation technique to carry out fat suppression, because the signal of fat is very high, do not suppress to disturb the contrast of blood vessel signal.
Step 308: apply the preparation radio-frequency pulse, use the linear preparation radio-frequency pulse that increases of 10 flip angles, make signal reach stable state.
Step 310: use bSSFP(balance Steady-State Free Precession: the balance steady state free precession) carry out " black arterial blood " blood-stream image collection.The SSFP sequence by propositions such as Oppelt, but due to the restriction of technical conditions at that time, can not be eliminated banding artifact as far back as 1986 effectively, and its application is restricted.In recent years, along with the gradient coil switching rate improves constantly, the application of SSFP aspect blood vessel imaging increases gradually, and because SSFP has extraordinary signal to noise ratio to blood, therefore, SSFP mainly is used in the cardiovascular imaging.Compare with traditional blood vessel imaging method (time leap, phase-contrast etc.), SSFP has that image taking speed is fast, signal to noise ratio is high, visual field is subjected to greatly and not the characteristics such as blood flow rate and aspect effect, thereby has been subject to the favor of numerous researcheres.At present, domestic and international SSFP mainly concentrates on the applied research of coronary artery and enlargement or puffiness of the chest and abdomen blood vessel imaging.As shown in Figure 5, wherein FS is fat suppression, and RF is radio frequency, and G1 is readout gradient.
Step 312: ecg-gating triggers in diastole;
Step 314:T2 prepares.T2 prepares to comprise by 90 ° of x-180 ° of rf pulse sequences that y-90 °-x forms, and the persistent period is identical with the rf pulse sequence of step 304, to guarantee having identical T2 weighted signal in vein and the stationary of systole and relaxing period collection.
Step 316: fat suppression, use spectral selection fat saturation technique to carry out fat suppression, because the signal of fat is very high, do not suppress to disturb the contrast of blood vessel signal.
Step 318: apply the preparation radio-frequency pulse, use the linear preparation radio-frequency pulse that increases of 10 flip angles, make signal reach stable state.
Step 320: use bSSFP to carry out " bright arterial blood " blood-stream image collection.As shown in Figure 6, wherein T2P is that T2 prepares, and FS is fat suppression, and RF is radio frequency, and G1 is readout gradient.
Step 322: subtract shadow and obtain final tremulous pulse image." bright blood " image and " black blood " image take FSD as preparation pulse generation of utilizing SSFP to produce both subtract each other the tremulous pulse image that just can obtain high-contrast.Because the image taking speed of SSFP and FSD is very fast, by ecg-gating, they can be placed in same cardiac cycle, reduced so to a great extent the registration mistake that causes because of the vessel position variation.In addition, SSFP is insensitive to blood flow rate, is applicable to the blood vessel imaging of the tortuous and slow blood flow of hand and foot traveling.
Fig. 7 illustrates the structural representation according to an embodiment of the application's Magnetic Resonance Angiography system, comprises systole image capture module, relaxing period image capture module and subtracts the shadow module.The systole image capture module was used within the vasoconstriction phase, apply the loose phase gradient of Flow sensitive magnetic field reading direction and/or phase-encoding direction and/or a choosing layer direction, at the gradient magnetic of the loose remaining magnetic moment of the after-applied removing in phase gradient magnetic field of Flow sensitive, gather the blood-stream image in the vasoconstriction phase.The relaxing period image capture module is used for gathering the blood-stream image in the vasodilation phase.Subtracting the shadow module is used for the blood-stream image in described systole and the blood-stream image in relaxing period are subtracted shadow acquisition blood-stream image.
A kind of embodiment, the systole image capture module comprises the FSD preparatory unit, is used in the paradoxical expansion that ecg-gating triggers, and is reading direction and/or phase-encoding direction and/or is selecting a layer direction to apply 90 °
x-180 °
y-90 °
-xRf pulse sequence and asymmetrical load are at 180 °
yThe loose phase gradient of the Flow sensitive on pulse both sides magnetic field applies in the pulse train back gradient magnetic of removing remaining magnetic moment.
A kind of embodiment, the first moment m in the loose phase gradient of Flow sensitive magnetic field
1Satisfy
Minimum, wherein φ is the resultant spin phase place, γ is the gyromagnetic ratio constant,
It is the flowing velocity of i spin.
A kind of embodiment, systole image capture module also are used for using spectral selection fat saturation technique to carry out fat suppression; Use the linear preparation radio-frequency pulse that increases of 10 flip angles; Balance steady state free precession technology gathers the blood-stream image in the vasoconstriction phase.
A kind of embodiment, relaxing period image capture module also are used for applying 90 ° in the diastole that ecg-gating triggers
x-180 °
y-90 °
-xRf pulse sequence; Use spectral selection fat saturation technique to carry out fat suppression; Use the linear preparation radio-frequency pulse that increases of 10 flip angles; Balance steady state free precession technology gathers the blood-stream image in the vasodilation phase.
Above content is the further description of the application being done in conjunction with concrete embodiment, can not assert that the application's concrete enforcement is confined to these explanations.For the application person of an ordinary skill in the technical field, under the prerequisite that does not break away from the application's design, can also make some simple deduction or replace.
Claims (10)
1. a Magnetic Resonance Angiography method, is characterized in that, comprising:
Within the vasoconstriction phase, apply the loose phase gradient of Flow sensitive magnetic field reading direction and/or phase-encoding direction and/or a choosing layer direction, at the gradient magnetic of the loose remaining magnetic moment of the after-applied removing in phase gradient magnetic field of described Flow sensitive;
Gather the blood-stream image in the vasoconstriction phase;
Gather the blood-stream image in the vasodilation phase;
Blood-stream image in described systole and the blood-stream image in relaxing period are subtracted shadow acquisition blood-stream image.
2. the method for claim 1, it is characterized in that, described within the vasoconstriction phase, apply the loose phase gradient of Flow sensitive magnetic field reading direction and/or phase-encoding direction and/or a choosing layer direction, gradient magnetic at the loose remaining magnetic moment of the after-applied removing in phase gradient magnetic field of described Flow sensitive comprises:
In the paradoxical expansion that ecg-gating triggers, reading direction and/or phase-encoding direction and/or selecting a layer direction to apply 90 °
x-180 °
y-90 °
-xRf pulse sequence and asymmetrical load are at 180 °
yThe loose phase gradient of the Flow sensitive on pulse both sides magnetic field applies in described pulse train back the gradient magnetic of removing remaining magnetic moment.
3. method as claimed in claim 2, is characterized in that, the first moment m in the loose phase gradient of described Flow sensitive magnetic field
1Satisfy
Minimum, wherein φ is the resultant spin phase place, γ is the gyromagnetic ratio constant,
It is the flowing velocity of i spin.
4. the method for claim 1, is characterized in that, the blood-stream image in the described collection vasoconstriction phase comprises:
Balance steady state free precession technology gathers the blood-stream image in the vasoconstriction phase.
5. the method for claim 1, is characterized in that, the blood-stream image in the described collection vasodilation phase comprises:
In the diastole that ecg-gating triggers, apply 90 °
x-180 °
y-90 °
-xRf pulse sequence;
Balance steady state free precession technology gathers the blood-stream image in the vasodilation phase.
6. a Magnetic Resonance Angiography system, is characterized in that, comprise systole image capture module, relaxing period image capture module and subtract the shadow module,
Described systole image capture module was used within the vasoconstriction phase, apply the loose phase gradient of Flow sensitive magnetic field reading direction and/or phase-encoding direction and/or a choosing layer direction, at the gradient magnetic of the loose remaining magnetic moment of the after-applied removing in phase gradient magnetic field of described Flow sensitive, gather the blood-stream image in the vasoconstriction phase;
Described relaxing period image capture module is used for gathering the blood-stream image in the vasodilation phase;
The described shadow module that subtracts is used for the blood-stream image in described systole and the blood-stream image in relaxing period are subtracted shadow acquisition blood-stream image.
7. system as claimed in claim 6, is characterized in that, described systole image capture module comprises the FSD preparatory unit, is used in the paradoxical expansion that ecg-gating triggers, and reading direction and/or phase-encoding direction and/or selecting a layer direction to apply 90 °
x-180 °
y-90 °
-xRf pulse sequence and asymmetrical load are at 180 °
yThe loose phase gradient of the Flow sensitive on pulse both sides magnetic field applies in described pulse train back the gradient magnetic of removing remaining magnetic moment.
8. system as claimed in claim 7, is characterized in that, the first moment m in the loose phase gradient of described Flow sensitive magnetic field
1Satisfy
Minimum, wherein φ is the resultant spin phase place, γ is the gyromagnetic ratio constant,
It is the flowing velocity of i spin.
9. system as claimed in claim 6, is characterized in that, described systole image capture module also is used for balance steady state free precession technology and gathers interior blood-stream image of vasoconstriction phase.
10. system as claimed in claim 6, is characterized in that, described relaxing period image capture module also is used for applying 90 ° in the diastole that ecg-gating triggers
x-180 °
y-90 °
-xRf pulse sequence; Balance steady state free precession technology gathers the blood-stream image in the vasodilation phase.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013100387664A CN103110420A (en) | 2013-01-31 | 2013-01-31 | Magnetic resonance angiography method and magnetic resonance angiography system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013100387664A CN103110420A (en) | 2013-01-31 | 2013-01-31 | Magnetic resonance angiography method and magnetic resonance angiography system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103110420A true CN103110420A (en) | 2013-05-22 |
Family
ID=48408819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2013100387664A Pending CN103110420A (en) | 2013-01-31 | 2013-01-31 | Magnetic resonance angiography method and magnetic resonance angiography system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103110420A (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103645453A (en) * | 2013-12-23 | 2014-03-19 | 厦门大学 | Method for obtaining single voxel one-dimensional localization spectra capable of eliminating scalar coupling modulation |
| CN103976735A (en) * | 2014-05-04 | 2014-08-13 | 清华大学 | Black blood film imaging method based on magnetic resonance |
| CN104545918A (en) * | 2014-12-29 | 2015-04-29 | 中国科学院深圳先进技术研究院 | Non-contract enhanced magnetic resonance venography imaging method |
| CN104644172A (en) * | 2013-11-25 | 2015-05-27 | 深圳先进技术研究院 | Method and system for controlling black blood in time-reversal steady state free precession quick imaging sequence |
| CN108567422A (en) * | 2018-03-02 | 2018-09-25 | 上海东软医疗科技有限公司 | A kind of blood vessel imaging method and apparatus |
| CN108652624A (en) * | 2017-03-31 | 2018-10-16 | 西门子(深圳)磁共振有限公司 | A kind of perspective electrocardio triggering method and device |
| WO2019169671A1 (en) * | 2018-03-05 | 2019-09-12 | 奥泰医疗系统有限责任公司 | Fat-suppressed black-blood magnetic resonance imaging method |
| CN110786842A (en) * | 2019-11-04 | 2020-02-14 | 苏州润迈德医疗科技有限公司 | Method, device, system and storage medium for measuring diastolic blood flow velocity |
| CN112986878A (en) * | 2019-12-18 | 2021-06-18 | 上海联影医疗科技股份有限公司 | Coronary artery imaging method and magnetic resonance imaging system |
| CN113900056A (en) * | 2021-10-18 | 2022-01-07 | 国家纳米科学中心 | Flow velocity measuring method, flow velocity measuring device and storage medium |
| WO2022105647A1 (en) * | 2020-11-23 | 2022-05-27 | 西安科锐盛创新科技有限公司 | Method for establishing enhanced three-dimensional model of intracranial angiography |
| WO2023122919A1 (en) * | 2021-12-27 | 2023-07-06 | 中国科学院深圳先进技术研究院 | Cardiac magnetic resonance diffusion tensor imaging method, apparatus and device, and storage medium |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8030919B2 (en) * | 2008-04-18 | 2011-10-04 | Case Western Reserve University | Dark blood balanced steady state free precession imaging |
| CN102551721A (en) * | 2011-12-12 | 2012-07-11 | 中国科学院深圳先进技术研究院 | Blood vessel imaging method and system |
-
2013
- 2013-01-31 CN CN2013100387664A patent/CN103110420A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8030919B2 (en) * | 2008-04-18 | 2011-10-04 | Case Western Reserve University | Dark blood balanced steady state free precession imaging |
| CN102551721A (en) * | 2011-12-12 | 2012-07-11 | 中国科学院深圳先进技术研究院 | Blood vessel imaging method and system |
Non-Patent Citations (1)
| Title |
|---|
| JOHN J.SHEEHAN等: "Nonenhanced MR angiography of the hand with flow-sensitive dephasing-prepared balanced ssfp sequence:initial experience with systemic sclerosis", 《RADIOLOGY》, 30 April 2011 (2011-04-30), pages 248 - 256 * |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104644172B (en) * | 2013-11-25 | 2017-11-03 | 深圳先进技术研究院 | The control method and system of black blood in time reversal stable state precession fast imaging sequences |
| CN104644172A (en) * | 2013-11-25 | 2015-05-27 | 深圳先进技术研究院 | Method and system for controlling black blood in time-reversal steady state free precession quick imaging sequence |
| CN103645453A (en) * | 2013-12-23 | 2014-03-19 | 厦门大学 | Method for obtaining single voxel one-dimensional localization spectra capable of eliminating scalar coupling modulation |
| CN103645453B (en) * | 2013-12-23 | 2016-03-09 | 厦门大学 | A kind of method obtaining the monomer element one dimension localization spectrum eliminating scalar coupling modulation |
| CN103976735B (en) * | 2014-05-04 | 2016-03-23 | 清华大学 | Based on the black blood film formation method of magnetic resonance |
| CN103976735A (en) * | 2014-05-04 | 2014-08-13 | 清华大学 | Black blood film imaging method based on magnetic resonance |
| CN104545918A (en) * | 2014-12-29 | 2015-04-29 | 中国科学院深圳先进技术研究院 | Non-contract enhanced magnetic resonance venography imaging method |
| CN108652624A (en) * | 2017-03-31 | 2018-10-16 | 西门子(深圳)磁共振有限公司 | A kind of perspective electrocardio triggering method and device |
| CN108567422A (en) * | 2018-03-02 | 2018-09-25 | 上海东软医疗科技有限公司 | A kind of blood vessel imaging method and apparatus |
| WO2019169671A1 (en) * | 2018-03-05 | 2019-09-12 | 奥泰医疗系统有限责任公司 | Fat-suppressed black-blood magnetic resonance imaging method |
| CN110786842A (en) * | 2019-11-04 | 2020-02-14 | 苏州润迈德医疗科技有限公司 | Method, device, system and storage medium for measuring diastolic blood flow velocity |
| CN112986878A (en) * | 2019-12-18 | 2021-06-18 | 上海联影医疗科技股份有限公司 | Coronary artery imaging method and magnetic resonance imaging system |
| WO2022105647A1 (en) * | 2020-11-23 | 2022-05-27 | 西安科锐盛创新科技有限公司 | Method for establishing enhanced three-dimensional model of intracranial angiography |
| CN113900056A (en) * | 2021-10-18 | 2022-01-07 | 国家纳米科学中心 | Flow velocity measuring method, flow velocity measuring device and storage medium |
| WO2023122919A1 (en) * | 2021-12-27 | 2023-07-06 | 中国科学院深圳先进技术研究院 | Cardiac magnetic resonance diffusion tensor imaging method, apparatus and device, and storage medium |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103110420A (en) | Magnetic resonance angiography method and magnetic resonance angiography system | |
| Fan et al. | 3D noncontrast MR angiography of the distal lower extremities using flow‐sensitive dephasing (FSD)‐prepared balanced SSFP | |
| Miyazaki et al. | Non-contrast-enhanced MR angiography of the abdomen | |
| US8332010B2 (en) | Method for non-contrast enhanced magnetic resonance angiography | |
| JP6656826B2 (en) | Magnetic resonance imaging equipment | |
| Cavallo et al. | Noncontrast magnetic resonance angiography for the diagnosis of peripheral vascular disease | |
| IL130991A (en) | Contrast-enhanced 3d mr angiography | |
| US9176212B2 (en) | Method for non-contrast enhanced magnetic resonance angiography | |
| WO2014085288A1 (en) | Noninvasive 4-d time-resolved dynamic magnetic resonance angiography | |
| Priest et al. | Non‐contrast‐enhanced vascular magnetic resonance imaging using flow‐dependent preparation with subtraction | |
| CN102551721B (en) | Blood vessel imaging method and system | |
| CN104814737B (en) | MR imaging apparatus and MR imaging method | |
| Javed et al. | Self‐gated 3D stack‐of‐spirals UTE pulmonary imaging at 0.55 T | |
| US8154287B2 (en) | System and method for ghost magnetic resonance imaging | |
| Edelman et al. | Quiescent‐inflow single‐shot magnetic resonance angiography using a highly undersampled radial k‐space trajectory | |
| US9720064B2 (en) | Variable TR (vTR) function in fresh blood imaging (FBI) | |
| Cho et al. | NMR angiography of coronary vessels with 2‐D planar image scanning | |
| Morelli et al. | Technical considerations in MR angiography: an image‐based guide | |
| Xiang et al. | Evaluation of regional variability and measurement reproducibility of Intravoxel incoherent motion diffusion weighted imaging using a cardiac stationary phase based ECG trigger method | |
| Laub | Principles of contrast-enhanced MR angiography: basic and clinical applications | |
| Fan et al. | Determination of the optimal first‐order gradient moment for flow‐sensitive dephasing magnetization‐prepared 3D noncontrast MR angiography | |
| Ivancevic et al. | Technical principles of MR angiography methods | |
| US9737222B2 (en) | Method for non-contrast enhanced magnetic resonance angiography | |
| US9414765B2 (en) | Fresh blood imaging (FBI) with independently controlled MRI data acquisition parameters for diastolic and systolic MRI acquisition sub-sequences | |
| Mihai et al. | Noncontrast MRA for the diagnosis of vascular diseases |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent of invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Liu Xin Inventor after: Fan Zhaoyang Inventor after: Zhang Na Inventor after: Chen Hanwei Inventor after: Zhong Yaozu Inventor after: Zheng Hairong Inventor after: Li Debiao Inventor before: Liu Xin Inventor before: Fan Zhaoyang Inventor before: Zhang Na Inventor before: Zhong Yaozu Inventor before: Zheng Hairong Inventor before: Li Debiao |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: LIU XIN FAN ZHAOYANG ZHANG NA ZHONG YAOZU ZHENG HAIRONG LI DEBIAO TO: LIU XIN FAN ZHAOYANG ZHANG NA CHEN HANWEI ZHONG YAOZU ZHENG HAIRONG LI DEBIAO |
|
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20130522 |