CN103099703A - Medicated composite silicon rubber assembly for intrauterine device - Google Patents
Medicated composite silicon rubber assembly for intrauterine device Download PDFInfo
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- CN103099703A CN103099703A CN2013100721265A CN201310072126A CN103099703A CN 103099703 A CN103099703 A CN 103099703A CN 2013100721265 A CN2013100721265 A CN 2013100721265A CN 201310072126 A CN201310072126 A CN 201310072126A CN 103099703 A CN103099703 A CN 103099703A
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- pastille
- silicone rubber
- rubber tube
- intrauterine device
- medicated
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Abstract
The invention relates to a medicated composite silicon rubber assembly for an intrauterine device. The medicated composite silicon rubber assembly comprises a non-medicated silicon rubber tube, wherein the middle of the silicon rubber tube is provided with at least one through hole through which a bracket passes; and the non-medicated outer layer of the silicon rubber tube is a medicated silicon rubber layer for releasing medicine.
Description
Technical field
The present invention relates to a kind of women assembly of intra-uterine contraceptive apparatus, particularly a kind of pastille composite silicone rubber assembly for intrauterine device.
Background technology
Intrauterine device (being called for short " birth control apparatus ") is the contraceptive device that is placed in women's cavity of uterus, is a kind of reversible, long-acting contraceptive device, is the widely used contraceptive devices of present China women of child-bearing age.
The medicated intrauterine devices that uses at present mainly contains two kinds, and is a kind of for the copper intrauterine devices increase contains indomethacin silicone rubber, another kind of for containing the intrauterine device of progestogen.
The form that contains indomethacin silicone rubber is the assemblies such as pipe, rod, piece or bar, or direct pressing is to birth control apparatus; The intrauterine device that contains progestogen adopts medicine and silicone rubber to extrude and makes tubular assembly.
Occupy-place in silicone rubber causes mechanical performance relatively poor to pastille silicone rubber assembly due to medicine, make the pastille assembly usually be difficult to be designed into the position that intrauterine device is kept structure or is subject to uterine pressure, for example: palace shape intrauterine device with the pastille assembly make that the pastille silicon rubber bar is hidden in that the spiral spring is inner, fixed intrauterine device makes the pastille assembly that the pastille silicon rubber bar is hidden in copper pipe inside, the V-arrangement memory alloy intrauterine device is made pastille silicone rubber tube string on two oblique arms with the pastille assembly.It is also to sacrifice the intrauterine device service life and dose is that (content of medicine can reach 60% or more to cost in theory that individual product is designed into these positions, but broken in order to prevent the pastille assembly, the actual content of medicine that uses is generally lower), for example: γ type intrauterine device with pastille silicone rubber assembly mould be pressed onto the end and in be formed centrally piece, but the medicament contg of piece is at 25%-30%, and service life lacks half than the intrauterine device of other same materials.
Summary of the invention
The object of the invention is to provide a kind of pastille composite silicone rubber assembly for intrauterine device, to overcome defects.
For achieving the above object, the pastille composite silicone rubber assembly for intrauterine device provided by the invention, its structure is: a pastille silicone rubber tube not, the centre has at least one through hole that wears support; The pastille silicone rubber tube is not outer for discharging the pastille silastic-layer of medicine.
Described pastille composite silicone rubber assembly, wherein, through hole is two.
Described pastille composite silicone rubber assembly, wherein, pastille silastic-layer contained drug is PGSI.
Described pastille composite silicone rubber assembly wherein, adopts extruder to process in the mode that the mode of coextrusion is processed, the separate unit extruder is extruded with coating or the mode machine-shaping of mold pressing.
Effect of the present invention is:
Pastille silicone rubber tube better mechanical property not, the key position that can be placed on intrauterine device works the function of keeping form or structure, especially at the center of intrauterine device; Medicated layer can design De Genggao owing to there being the inner not structure of pastille silicone rubber tube to keep drugs with function content; Improvement of the present invention can make medicated intrauterine devices in the shape design, more selection be arranged.
in addition, the present invention also has following unexpected effect, not pastille silicone rubber tube mechanical performance height also mean the blockage effect of medicine good, mechanical performance usually adopts and use more reinforcing agent silicon dioxide in formula, increasing the thickness of pipe or the method that two alkyl that are connected with Si in rubber are replaced improves, this is consistent with improving silicone rubber tube to the method for drug molecule blockage effect, namely with respect to the pastille silastic-layer not the pastille silicone rubber tube drug molecule is had certain blockage effect, make medicine be substantially unidirectional release (with respect to simple pastille silicone rubber tube).Simultaneously due to the pastille silastic-layer outside, drug molecule is from the distance difference on surface less (with respect to pastille silicon rubber bar, piece or the bar of solid type), therefore discharge more stable, its release behavior is that initial penetration discharges (approximately 3-4 days), a high-releasing amount stage of stable development more than 10 days is arranged afterwards, then slow decreasing, until drug release is complete, deenergized period was greater than 100 days.
Description of drawings
Fig. 1 is the structural representation that the present invention is used for the single-pass hole pastille composite silicone rubber assembly of intrauterine device.
Fig. 2 is the structural representation that the present invention is used for the doubled via pastille composite silicone rubber assembly of intrauterine device.
The number in the figure explanation:
1 is the pastille silastic-layer, and 2 are pastille silicone rubber tube not, and 3 is through hole.
The specific embodiment
As depicted in figs. 1 and 2, pastille composite silicone rubber assembly for intrauterine device of the present invention, be to be coated with the pastille silastic-layer 1 that discharges medicine in the outside of pastille silicone rubber tube 2 not, in pastille silastic-layer 1, contained medicine is for example PGSI.The centre of pastille silicone rubber tube 2 is not the through hole 3 that passes for support, and this through hole 3 can be single-pass hole (as shown in Figure 1), can be also doubled via (as shown in Figure 2).
Pastille silicone rubber tube better mechanical property not, the key position that can be placed on intrauterine device works the function of keeping form or structure, especially at the center of intrauterine device; Medicated layer can design De Genggao owing to there being the inner not structure of pastille silicone rubber tube to keep drugs with function content; Improvement of the present invention can make medicated intrauterine devices in the shape design, more selection be arranged.
not pastille silicone rubber tube mechanical performance height also mean the blockage effect of medicine good, mechanical performance usually adopts and use more reinforcing agent silicon dioxide in formula, increasing the thickness of pipe or the method that two alkyl that are connected with Si in rubber are replaced improves, this is consistent with improving silicone rubber tube to the method for drug molecule blockage effect, namely with respect to the pastille silastic-layer not the pastille silicone rubber tube drug molecule is had certain blockage effect, drug main will be discharged to the medicated layer outer surface, namely be substantially unidirectional release (with respect to simple pastille silicone rubber tube).Simultaneously due to the pastille silastic-layer outside, drug molecule is from the distance difference on surface less (with respect to pastille silicon rubber bar, piece or the bar of solid type), therefore discharge more stable, its release behavior is that initial penetration discharges (approximately 3-4 days), a high-releasing amount stage of stable development more than 10 days is arranged afterwards, then slow decreasing, until drug release is complete, deenergized period was greater than 100 days.
Structure medicament release breakthrough release period of the present invention and the high-releasing amount stage of stable development more meet the clinical practice of PGSI in intrauterine device more than two weeks.
Pastille composite silicone rubber assembly of the present invention can adopt mode that extruder extrudes with coating with the mode of coextrusion, separate unit extruder or the mode machine-shaping of mold pressing.
Do below in conjunction with accompanying drawing and illustrate.
Embodiment 1
Pastille composite silicone rubber assembly is the coextrusion goods, internal layer is pastille silicone rubber tube 2 not, pastille silicone rubber tube 2 can not be single hole or diplopore, be used for passing for the support that the silk material is made, the skin of pastille silicone rubber tube 2 is not for containing indomethacin silastic-layer 1 (pastille silastic-layer 1 of the present invention is to adopt known technology to be prepared from).Support is the Y shaped bracket that tinsel is made, and the pastille silicone rubber tube is positioned at (known technology, not shown in the figures) on trailing arm.
Embodiment 2
Pastille composite silicone rubber assembly is the coextrusion goods, and internal layer is pastille silicone rubber tube 2 not, and the through hole 3 in the middle of pastille silicone rubber tube 2 is not for single hole or diplopore pass for support, and the skin of pastille silicone rubber tube 2 is not for containing indomethacin silastic-layer 1.Support is T shape support, and pastille composite silicone rubber pipe is positioned at (known technology, not shown in the figures) on T shape trailing arm.
Pastille composite silicone rubber assembly is the coextrusion goods, and internal layer is pastille silicone rubber tube 2 not, and the through holes 3 in the middle of pastille silicone rubber tube 2 can not be that single hole or diplopore pass for support, and the skin of pastille silicone rubber tube 2 is not for containing indomethacin silastic-layer 1.Support is Y shape, V-arrangement or T shape support, and pastille composite silicone rubber pipe is positioned on the oblique arm or transverse arm of Y shape, V-arrangement or T shape support (known technology, not shown in the figures).
Embodiment 4
Pastille composite silicone rubber assembly is pressing, and internal layer is pastille silicone rubber tube 2 not, and the through holes 3 in the middle of retardance silicone rubber tube 2 can be that single hole or diplopore pass for support, and the skin of pastille silicone rubber tube 2 is not for containing indomethacin silastic-layer 1.Support is the spiral spring γ shape support that tinsel is made, and pastille composite silicone rubber pipe is positioned at the top (known technology, not shown in the figures) of trailing arm.
Embodiment 5
Pastille composite silicone rubber assembly is the coextrusion goods, and internal layer is pastille silicone rubber tube 2 not, and the through holes 3 in the middle of pastille silicone rubber tube 2 can not be that single hole or diplopore pass for support, and the skin of pastille silicone rubber tube 2 is not for containing indomethacin silastic-layer 1.Adopt single surgical thread to pass through hole and copper pipe string together, be made into without bracket intrauterine device (known technology, not shown in the figures).
Claims (6)
1. be used for the pastille composite silicone rubber assembly of intrauterine device, its structure is:
One pastille silicone rubber tube not, the centre has at least one through hole that wears support;
The pastille silicone rubber tube is not outer for discharging the pastille silastic-layer of medicine.
2. pastille composite silicone rubber assembly according to claim 1, wherein, the through hole in the middle of the pastille silicone rubber tube is not two.
3. pastille composite silicone rubber assembly according to claim 1 and 2, wherein, pastille silastic-layer contained drug is PGSI.
4. pastille composite silicone rubber assembly according to claim 1 and 2, wherein, adopt extruder with the mode machine-shaping of coextrusion.
5. pastille composite silicone rubber assembly according to claim 1 and 2, wherein, the mode machine-shaping of adopting the separate unit extruder to extrude with coating.
6. pastille composite silicone rubber assembly according to claim 1 and 2, wherein, adopt the mode machine-shaping of mold pressing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013100721265A CN103099703A (en) | 2013-03-06 | 2013-03-06 | Medicated composite silicon rubber assembly for intrauterine device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013100721265A CN103099703A (en) | 2013-03-06 | 2013-03-06 | Medicated composite silicon rubber assembly for intrauterine device |
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| Publication Number | Publication Date |
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| CN103099703A true CN103099703A (en) | 2013-05-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2013100721265A Pending CN103099703A (en) | 2013-03-06 | 2013-03-06 | Medicated composite silicon rubber assembly for intrauterine device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106344970A (en) * | 2016-08-30 | 2017-01-25 | 烟台计生药械有限公司 | Burst release removing method of indometacin silicone elastomer medicament strips for intrauterine device |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1382500A (en) * | 2001-04-25 | 2002-12-04 | 上海市计划生育科学研究所 | Medicine for vaginal ring and its application |
| CN1463762A (en) * | 2002-06-07 | 2003-12-31 | 上海市计划生育科学研究所 | Novel pessary and method for preparing same |
| CN1548014A (en) * | 2003-05-08 | 2004-11-24 | 上海市计划生育科学研究所 | Making process of intrauterine medicine releasing device |
| CN201119944Y (en) * | 2007-05-25 | 2008-09-24 | 广东省计划生育科学技术研究所 | Silicon rubber intrauterine device |
| CN101278872A (en) * | 2007-04-05 | 2008-10-08 | 辽宁爱母医疗科技有限公司 | Nano memory alloy intrauterine device |
| CN202724077U (en) * | 2012-07-16 | 2013-02-13 | 烟台计生药械有限公司 | Intrauterine device with memory function |
-
2013
- 2013-03-06 CN CN2013100721265A patent/CN103099703A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1382500A (en) * | 2001-04-25 | 2002-12-04 | 上海市计划生育科学研究所 | Medicine for vaginal ring and its application |
| CN1463762A (en) * | 2002-06-07 | 2003-12-31 | 上海市计划生育科学研究所 | Novel pessary and method for preparing same |
| CN1548014A (en) * | 2003-05-08 | 2004-11-24 | 上海市计划生育科学研究所 | Making process of intrauterine medicine releasing device |
| CN101278872A (en) * | 2007-04-05 | 2008-10-08 | 辽宁爱母医疗科技有限公司 | Nano memory alloy intrauterine device |
| CN201119944Y (en) * | 2007-05-25 | 2008-09-24 | 广东省计划生育科学技术研究所 | Silicon rubber intrauterine device |
| CN202724077U (en) * | 2012-07-16 | 2013-02-13 | 烟台计生药械有限公司 | Intrauterine device with memory function |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106344970A (en) * | 2016-08-30 | 2017-01-25 | 烟台计生药械有限公司 | Burst release removing method of indometacin silicone elastomer medicament strips for intrauterine device |
| CN106344970B (en) * | 2016-08-30 | 2019-04-12 | 烟台计生药械有限公司 | A kind of intrauterine device Indomethacin silicon rubber medicinal strip goes burst release method |
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Application publication date: 20130515 |