CN103099610A - Ambulatory blood pressure measuring device and method based on pulse wave transmission time difference of left brachial artery and right brachial artery - Google Patents

Ambulatory blood pressure measuring device and method based on pulse wave transmission time difference of left brachial artery and right brachial artery Download PDF

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CN103099610A
CN103099610A CN2011103578626A CN201110357862A CN103099610A CN 103099610 A CN103099610 A CN 103099610A CN 2011103578626 A CN2011103578626 A CN 2011103578626A CN 201110357862 A CN201110357862 A CN 201110357862A CN 103099610 A CN103099610 A CN 103099610A
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张珣
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Zhejiang Morgan Intelligent Technology Co., Ltd.
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Hangzhou Electronic Science and Technology University
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Abstract

The invention discloses an ambulatory blood pressure measuring device and method based on pulse wave transmission time difference of a left brachial artery and a right brachial artery. The ambulatory blood pressure measuring device comprises a pulse wave acquiring probe, a data processing analog circuit unit and an ambulatory blood pressure meter main body portion. The pulse wave acquiring probe is electrically connected with the data processing analog circuit unit, the data processing analog circuit unit is electrically connected with the ambulatory blood pressure meter main body portion, the pulse wave acquiring probe acquires blood pressure data and transfers the blood pressure data to the data processing analog circuit unit, the data processing analog circuit unit preprocesses received data and sends the pre-processed data to the ambulatory blood pressure meter main body portion, and the ambulatory blood pressure meter main body portion processes pulse wave data and calculates a blood pressure numerical value. The ambulatory blood pressure measuring device and method can dynamically monitor blood pressure and reduce the requirement for gestures of measured persons, measurement can be performed in normal life, 24-hour blood pressure monitoring is conveniently achieved, and normal life of the measured persons is basically not influenced.

Description

Ambulatory blood pressure measuring device and method based on left and right brachial pulse ripple transmission time difference
[technical field]
The invention belongs to the blood pressure measurement technical field, relate to a kind of device and method of dynamic output blood pressure values, specifically a kind of device and method that utilizes pulse wave transmission speed method to carry out the non-intrusion type continuous BP measurement.
[background technology]
At present, blood pressure measuring device commonly used has mercurial sphygmomanometer, based on the electric sphygmomanometer of vibration measuring method etc., and these sphygomanometers all need the cuff that can inflate, it is surrounded on measured's arm measures.Announce about the patent of this type of blood pressure measuring device is existing, such as United States Patent (USP) 4625277,5215096 and 6602200 etc.All unload theoretical based on blood vessel based on the electric sphygmomanometer of vibration measuring method and Ke's formula sound method of mercurial sphygmomanometer employing.Counting example based on the electronic blood pressure of vibration measuring method, during greater than systolic pressure, tremulous pulse is closed when static pressure in cuff, the impact of cuff endogenous cause of ill near-end pulse and by a small margin the wave of oscillation occurs; During less than systolic pressure, wave amplitude increases gradually when static pressure; When static pressure equaled mean arterial pressure, ductus arteriosus wall was in load condition, and it is maximum that wave amplitude reaches.Static pressure during less than mean arterial pressure wave amplitude reduce gradually, after venous pressure was less than diastolic pressure, ductus arteriosus wall was in fully expansion of relaxing period, wave amplitude maintains less level.So just can obtain easypro arteriotony by the automatic measurement of pressure transducer.
The cuff type blood pressure measuring method is widely used clinically, but there is following shortcoming in the cuff type sphygomanometer: the first, inflation/deflation needs a process, this has just determined to measure a blood pressure need to spend the long time, blood pressure signal between twice blood pressure measurement process can't be monitored, and fluctuation has probably occured in blood pressure during this period of time, blood pressure signal will be missed like this, and obviously the timing blood pressure measurement in past can't satisfy the demands.The second, cuff is surrounded on and carries out inflation/deflation on arm, can cause measured's sense of discomfort, especially in the situation that frequent the measurement when serious, even can measured's the tissues such as skin be caused damage.Therefore, need a kind of novel non-cuff type dynamic hemomanometer of development.
The continuous non-invasive blood pressure measurement is to complete the measurement of blood pressure in each cardiac cycle.Some noinvasive continuous blood pressure monitoring methods occurred at present, wherein a kind of method utilizes the pulse wave transmission speed to come calculating blood pressure exactly.The intermittence of heart is shunk diastole and is penetrated blood and will produce from arterial root section, along the pulse wave of arterial rete propagation.Pulse wave transmission speed (Pulse wave velocity, PWV) refers to that pulse refers to namely that along the speed of tremulous pulse conduction pulse wave is transmitted to the speed of another point from a specified point of tremulous pulse along tube wall.Correlational study proves, the pulse wave transmission speed is relevant to blood pressure, United States Patent (USP) 5649543,5865543 and 6599251 and some other patent documentation openly utilize pulse wave transmission time or pulse wave transmission speed to come the method for pre-measuring blood pressure.
At present, the acquisition methods of pulse wave transmission speed mainly comprises following a few class: pulse wave transmission speed method is calculated in the single armed sampling of (1) sampling wrist radial artery and arm brachial artery place pulse wave; (2) sampling wrist radial artery calculates the pulse wave velocity method in conjunction with the electrocardiosignal characteristic point; (3) utilize the pulse wave velocity computational methods of photoelectricity volume descriptive method sampling fingertip pulse wave signal.
Above-mentioned (2) plants the sampling pulse wave, is to realize dynamic monitoring according to the advantage of pulse wave transmission speed Measure blood pressure, farthest obtains blood pressure information, the omission of critical data can not occur; And this method does not need cuff, the body injury of so just having avoided long-time repeated measure to cause.But the existing method of utilizing pulse wave transmission speed Measure blood pressure also has the deficiency of himself, mainly contain following some:
The first, pulse wave will be calibrated for different user, namely sets up the relation of pulse wave transmission speed and measured's blood pressure, even and same user also need regularly to calibrate, to improve the blood pressure measurement precision.But collimation technique existing problems, pulse wave by the tremulous pulse point-to-point transmission calculates the pulse wave transmission speed, the pressure value that recorded by cuff sphygmomanometer is at that time calibrated, and in using afterwards, the position of sampled point might be offset, so just having a length of vessel is the error of pulse wave transmission range, and it will directly cause the increase of final blood pressure output error.If overcome this error, need to calibrate when each the use, but be obviously pretty troublesome.
The second, sampling deficient in stability, because the method for sampling is generally selected the wrist radial artery or passed through photoelectricity volume descriptive method sampling fingertip pulse wave, these Comparison of Gardening Activities for human body are responsive, therefore require the measured to keep static during measuring, this is unfavorable for realizing the dynamic monitoring of 24 hours.
[summary of the invention]
The above-mentioned technical problem that exists for solving prior art the invention discloses a kind of ambulatory blood pressure measuring device and method based on left and right brachial pulse ripple transmission time difference.
the present invention takes following technical scheme: based on the ambulatory blood pressure measuring device of left and right brachial pulse ripple transmission time difference, comprise the pulse wave acquisition probe, the simulation of data processing circuit unit, the dynamic hemomanometer main part, the pulse wave acquisition probe is electrically connected to the simulation of data processing circuit unit, the simulation of data processing circuit unit is electrically connected to the dynamic hemomanometer main part, the pulse wave acquisition probe gathers blood pressure data and is transferred to the simulation of data processing circuit unit, the simulation of data processing circuit unit carries out pretreatment with the data that receive, and preprocessed data is sent to the dynamic hemomanometer main part, the dynamic hemomanometer main part is carried out the processing of pulse wave data and the calculating of blood pressure values.
Described ambulatory blood pressure measuring device, the dynamic hemomanometer main part comprises data acquisition unit, data processing unit, data output unit and control unit, data acquisition unit is connected and communication with the simulation of data processing circuit unit, data acquisition unit is connected with data processing unit, data processing unit is connected with data output unit, control unit again, and described data acquisition unit becomes the manageable digital signal of data processing unit with the analog signal conversion of simulation of data processing circuit unit collection; Data processing unit is processed the pulse wave signal of data acquisition unit output, calculates blood pressure values, to the output of data output unit, has simultaneously the function that sends instruction to control unit; Control unit offers data processing unit with measurement result, is used for calibration; The data output unit is with final pressure value and the pulse waveform output of data processing unit transmission.
Described ambulatory blood pressure measuring device, data acquisition unit adopts AD converter.
Described ambulatory blood pressure measuring device, the data output unit adopts the LCD liquid crystal display screen.
Described ambulatory blood pressure measuring device, the pulse wave acquisition probe adopts pulse wave sensor, is output as ultra-weak electronic signal.
Described ambulatory blood pressure measuring device, pulse wave sensor adopts the difference pulse wave sensor of two collection points.
Described ambulatory blood pressure measuring device, data processing unit directly are plugged on described ambulatory blood pressure machine main part.
The present invention is based on the ambulatory blood pressure measuring method of left and right brachial pulse ripple transmission time difference, it carries out as follows:
At first, the pulse wave wave sensor is attached at left and right arms brachial artery place, sampling left and right arms brachial pulse ripple signal converts numerical signal to through A/D;
Then, judge whether it is to use for the first time, if begin calibration process: utilize blood pressure measuring to take blood pressure, record successively first feature blood pressure, second feature blood pressure, then enter and wait for and read the A/D transformation result; If not, wait for and read the A/D transformation result;
After waiting for and read the A/D transformation result, carry out successively data filtering, calculate phase contrast, calculating blood pressure, system filter;
Then, judge whether the protocols having request, if, request data output, then enter pulse wave, blood pressure, pulse frequency output and show; If not, enter pulse wave, blood pressure, pulse frequency output and demonstration;
At last, be back to and wait for and read the A/D transformation result.
Theoretical basis of the present invention is: because most human hearts are taken back, this has just determined to arrive from heart the distance difference of left and right arm brachial artery, and this segment distance is poor relatively fixing with regard to each is individual, and pulse wave arrival left and right arms brachial artery collection point has just had a stable transmission range poor like this.Thereby, recording corresponding pulse wave transmission time after the recovery, initialize demarcation in conjunction with electric sphygmomanometer, just can set up the relation of pulse wave transmission speed and blood pressure.
Ambulatory blood pressure measurement of the present invention overcome traditional cuff type sphygomanometer can't dynamic monitoring and the inflation/deflation operation may be to the shortcoming of measured's when injected organism tissue injury; also realized the monitoring of blood pressure in the normal activity situation and reduced the ambulatory blood pressure monitoring calibration frequency; it can realize that whole day continues to monitor blood pressure; and because measured's non-strenuous exercise is less to the fluctuation that this device blood pressure output valve causes, so this blood pressure measuring device is less on the impact of measured's daily routines.
Ambulatory blood pressure of the present invention is measured Monitoring of blood pressure dynamically, and reduction can measure in orthobiosis the requirement of gauger's attitude, conveniently realizes 24 hours whole-day blood pressure monitorings and does not substantially affect measured's orthobiosis.In addition, the range difference that arrives heart due to each individual left and right arms brachial artery is a constant basis, has so just avoided the common measurement error that causes due to two point measurement variable in distance in the blood pressure measuring device based on pulse wave transmission speed method.
[description of drawings]
Fig. 1 is the structural representation of ambulatory blood pressure measuring device of the present invention.
Fig. 2 is the structured flowchart of dynamic hemomanometer main part of the present invention.
Fig. 3 is left and right arms brachial pulse ripple transmission time difference schematic diagram.
Fig. 4 is pulse wave acquisition probe structural design drawing.
Fig. 5 is the upward view of pulse wave acquisition probe.
Fig. 6 is the left view of pulse wave acquisition probe.
Fig. 7 is the circuit diagram of simulation of data processing circuit unit of the present invention.
Fig. 8 is the flow chart of ambulatory blood pressure measuring method of the present invention.
[specific embodiment]
Below in conjunction with the drawings and specific embodiments, this patent is described further.
With reference to Fig. 1, the ambulatory blood pressure measuring device comprises pulse wave acquisition probe 101, simulation of data processing circuit unit 102, dynamic hemomanometer main part 103.Pulse wave acquisition probe 101 is electrically connected to by custom interface with simulation of data processing circuit unit 102, and simulation of data processing circuit unit 102 is electrically connected to dynamic hemomanometer main part 103.Wherein, pulse wave acquisition probe 101 can adopt the flexible material making such as pvdf membrane, can be also the pulse wave sensor that the encapsulation such as photodiode, piezoelectric ceramic piece form, and is output as ultra-weak electronic signal.The present embodiment adopts the difference pulse wave sensor, as shown in Fig. 4-6, and the preferred design of adopting two collection points, it can carry out difference processing to signal, compares the collection pulse wave signal that existing pulse wave sensor can be more stable.The two arm brachial artery places that pulse wave acquisition probe 101 is attached at respectively the measured (make the arteries length difference of measuring the pulse wave transmission time difference keep constant, avoided being offset because of sampled point the measurement error that causes), be responsible for gathering blood pressure data and also be transferred to simulation of data processing circuit unit 102.Pulse wave sensor can be attached at arm brachial artery place and not need cuff, can not damage human body (gluing getting final product, adopt medical rubberized fabric adhere also can).Simulation of data processing circuit unit 102 can directly be plugged on main part 103, also can be connected with main part 103 by wire.Simulation of data processing circuit unit 102 carries out pretreatment with left and right brachial artery signal, comprises the processing such as amplification, filtering (comprising difference), and preprocessed data is sent to dynamic hemomanometer main part 103.The circuit theory of simulation of data processing circuit unit 102 sees Fig. 7 for details.Main part 103 is carried out the processing of pulse wave data and calculating and the output of blood pressure values.
With reference to Fig. 2, dynamic hemomanometer main part 103 comprises data acquisition unit 201, data processing unit 202, data output unit 203 and nominal data input block, data acquisition unit 201 is connected and communication with simulation of data processing circuit unit 102, data acquisition unit 201 is connected with data processing unit 202 electricity, and data processing unit 202 is connected with data output unit 203, nominal data input block 204 electricity again.The prior art that can adopt above-mentioned data acquisition unit 201, data processing unit 202, data output unit 203 and nominal data input block 204 realizes that they are made on the same circuit board usually.For example, data acquisition unit 201 can adopt various AD converters, and the analog signal conversion that it is responsible for simulation of data processing circuit unit 102 is gathered is to the manageable digital signal of data processing unit 202.Data processing unit 202 can adopt take various microprocessors as core and build, be responsible for the pulse wave signal of data acquisition unit 201 outputs is processed, calculate blood pressure values, to data output unit 203 output, have simultaneously and accept nominal data that nominal data input block 204 transmits and be used for pressure value and calculate.Nominal data input block 204 is responsible for input nominal data, the preferred keyboard in nominal data unit usually when using first.Data output unit 203 can adopt various Digital output instruments, as the LCD liquid crystal display screen, is responsible for final pressure value and pulse waveform output with data processing unit 202 transmission.
Concrete measuring process: at first, with the parallel arm brachial artery place be fixed in of two pulse wave acquisition probe 101, so just can guarantee that the range difference of two tremulous pulse sampled points arrival hearts remains unchanged, avoid pulse wave transmission range error.Because when the left and right sampled point is symmetrical, sampled point arrives the heart range difference by the position degree decision of heart off-center, and heart off-center degree is a definite value with regard to individual, and this has just determined that also the pulse wave transmission time difference is a definite value, as shown in Figure 3.Then, with main part 103, simulation of data processing circuit unit 102 by the fabrics such as belt fixing with measured's health on, can begin to carry out the measurement of blood pressure.
The pulse wave wave sensor is attached at left and right arms brachial artery place, and sampling left and right arms brachial pulse ripple transmission time difference has improved pulse wave transmission time difference sampling precision.Utilize sphygomanometer to calibrate, this need to use first and later use in regularly be generally per month once, utilize sphygomanometer numerical value and pulse wave transmission time opening relationships equation, and record equation coefficient (blood pressure that vide infra calculating).At first use traditional sphygomanometer to record two feature pressure value P0 and P1, be input to data processing unit 202 by nominal data input block 204, at this moment the program of data processing unit 202 can be in the demarcation subprogram, data processing unit 202 can gather front end pulse ripple calculated signals and measure the pulse wave transmission time difference, set up the relation equation of pulse wave transmission time and blood pressure, and equation coefficient is stored in internal memory goes.So just completed primary calibration.In most cases, obtain blood pressure and pulse wave transmission time relation equation coefficient, do not needed sphygomanometer to calibrate.
The pulse wave data acquisition:
1, two pulse wave acquisition probe 101 are attached at arm brachial artery place, left and right and obtain faint pulse wave signal;
2,201 pairs of front end signals of data acquisition unit carry out the analog circuit date processing, comprise filter circuit, amplifying circuit etc.;
3, analog to digital conversion circuit becomes digital signal with the analog signal conversion of data acquisition unit 201 outputs, and this paper analog-digital converter is included in data processing unit 202.
Through these three steps, the pulse wave digital signal has gathered and has completed.
The data handling procedure of pulse wave comprises:
1, digital filtering comprises medium filtering etc., and these digital filter programs are very ripe, more common, no longer describes in detail.
2, the calculating of cycle T: computation of Period is calculated by judgement pulse wave digital signal peak value, calculates adjacent peaks sampled point time difference and is pulse wave cycle T.
3, phase contrast
Figure BDA0000107675370000061
Calculating, calculate the phase contrast of two-way pulse wave data, owing to the two-way pulse wave signal being converted to for digital signal, be assumed to be Y[n], X[n].So just can adopt the method for Digital Signal Processing to calculate by data processing unit 202, preferred scheme be to utilize DFT to calculate phase contrast, also can adopt crest to detect, and namely monitors the method for two paths of signals crest sampled point time difference.The scheme of DFT calculating blood pressure is: two-way pulse wave digital signal is respectively DFT calculates, directly calculate the first phase of first-harmonic, then do the poor phase contrast of obtaining.Computational process is as follows:
X ( m ) = Σ n = 0 N - 1 x ( n ) e ( - j 2 πnm / N ) - - - ( 1 )
= Σ n = 0 N - 1 x ( n ) [ cos ( 2 πnm / N ) - j sin ( 2 πnm / N ) ]
Wherein n is sampling number, and m is overtone order, gets 1 here.
The real part that makes X (m) is Re[X (m)], imaginary part is Im[X (m)], can calculate the signal first phase:
Figure BDA0000107675370000064
In like manner can calculate other one road signal initial phase:
Figure BDA0000107675370000066
(4)
(4) formula is the phase contrast result of calculating.
4, phase contrast is converted to time difference, supposes that transmission time difference is t,
The calculating of blood pressure: existing document and patent has been proved the blood pressure amount and the Pulse transit time variable quantity is directly proportional.So also just can estimate according to the variable quantity in pulse wave transmission time the variable quantity of blood pressure.Suppose that blood pressure is P, the transmission time is t, can get following formula:
ΔP=aΔt P-P 0=a(t-t 0) (5)
P=at-(at 0+P 0) (6)
Formula (6) can be reduced to P=at-b (7)
So just can find out that blood pressure and transmission time are roughly once linear relationships, and the parameters such as blood vessel wall thickness of human body can be thought and can not change in the short time, so just can by once or traditional blood pressure measurement repeatedly to a that gets parms, b, then calculate the ambulatory blood pressure value by formula (7).
Electric sphygmomanometer is now very ripe, utilizes traditional sphygomanometer to measure a blood pressure values, substitution formula (7), and the phase contrast in conjunction with (4) formula is calculated can calculate parameter a, b.Like this, data processing unit 202 just can be exported blood pressure values in real time.
Compare with existing sphygomanometer, blood pressure parameter measuring device provided by the invention has advantages of can be realized comfortable measurement and reduce the calibration number of times, and it can be worn on measured's body easily, and can measured's daily life not impacted.
Referring to Fig. 8, the present invention is based on the method for the ambulatory blood pressure measurement of left and right brachial pulse ripple transmission time difference, step is as follows:
At first, the pulse wave wave sensor is attached at left and right arms brachial artery place, sampling left and right arms brachial pulse ripple signal converts numerical signal to through A/D;
Then, judge whether it is to use for the first time, need to calibrate if use first, beginning calibration process: utilize blood pressure measuring to take blood pressure, record successively first feature blood pressure, second feature blood pressure, then enter and wait for and read the A/D transformation result; If not, wait for and read the A/D transformation result;
After waiting for and read the A/D transformation result, carry out successively data filtering, calculate phase contrast, calculating blood pressure, system filter;
Then, judge whether the protocols having request, if, request data output, then enter pulse wave, blood pressure, pulse frequency output and show; If not, enter pulse wave, blood pressure, pulse frequency output and demonstration;
At last, be back to and wait for and read the A/D transformation result.
In aforementioned process:
Calculate phase contrast
Figure BDA0000107675370000071
Calculate the phase contrast of two-way pulse wave data, owing to the two-way pulse wave signal being converted to for digital signal, be assumed to be Y[n], X[n].So just can adopt the method for Digital Signal Processing to calculate by data processing unit 202, preferred scheme be to utilize DFT to calculate phase contrast, also can adopt crest to detect, and namely monitors the method for two paths of signals crest sampled point time difference.The scheme of DFT calculating blood pressure is: two-way pulse wave digital signal is respectively DFT calculates, directly calculate the first phase of first-harmonic, then do the poor phase contrast of obtaining.Computational process is as follows:
X ( m ) = Σ n = 0 N - 1 x ( n ) e ( - j 2 πnm / N ) - - - ( 1 )
= Σ n = 0 N - 1 x ( n ) [ cos ( 2 πnm / N ) - j sin ( 2 πnm / N ) ]
Wherein n is sampling number, and m is overtone order, gets 1 here.
The real part that makes X (m) is Re[X (m)], imaginary part is Im[X (m)], can calculate the signal first phase:
Figure BDA0000107675370000081
In like manner can calculate other one road signal initial phase:
Figure BDA0000107675370000082
Figure BDA0000107675370000083
(4)
Figure BDA0000107675370000084
(4) formula is the phase contrast result of calculating.
Phase contrast is converted to time difference, supposes that transmission time difference is t,
Figure BDA0000107675370000085
Calculating blood pressure: existing document and patent has been proved the blood pressure amount and the Pulse transit time variable quantity is directly proportional.So also just can estimate according to the variable quantity in pulse wave transmission time the variable quantity of blood pressure.Suppose that blood pressure is P, the transmission time is t, can get following formula:
ΔP=aΔt P-P 0=a(t-t 0) (5)
P=at-(at 0+P 0) (6)
Formula (6) can be reduced to P=at-b (7)
So just can find out that blood pressure and transmission time are roughly once linear relationships, and the parameters such as blood vessel wall thickness of human body can be thought and can not change in the short time, so just can by once or traditional blood pressure measurement repeatedly to a that gets parms, b, then calculate the ambulatory blood pressure value by formula (7).
System filter and data filtering are simple data filtering, remove High-frequency Interference and make digital signal more stable, and this is current techique, no longer describes in detail.
The method that ambulatory blood pressure of the present invention is measured can be carried out based on ambulatory blood pressure measuring device of the present invention, also can independently carry out.
The specific preferred embodiment of above combination has at length been set forth the present invention.Yet the description that these are detailed and concrete example are only a kind of explanation but not limitation of the invention, and for those of ordinary skills, the explanation detailed according to these obviously can be made various modification and distortion within the scope of the present invention.

Claims (8)

1. based on the ambulatory blood pressure measuring device of left and right brachial pulse ripple transmission time difference, it is characterized in that comprising the pulse wave acquisition probe, the simulation of data processing circuit unit, the dynamic hemomanometer main part, the pulse wave acquisition probe is electrically connected to the simulation of data processing circuit unit, the simulation of data processing circuit unit is electrically connected to the dynamic hemomanometer main part, the pulse wave acquisition probe gathers blood pressure data and is transferred to the simulation of data processing circuit unit, the simulation of data processing circuit unit carries out pretreatment with the data that receive, and preprocessed data is sent to the dynamic hemomanometer main part, the dynamic hemomanometer main part is carried out the processing of pulse wave data and the calculating of blood pressure values.
2. ambulatory blood pressure measuring device as claimed in claim 1, it is characterized in that: described dynamic hemomanometer main part comprises data acquisition unit, data processing unit, data output unit and control unit, data acquisition unit is connected and communication with the simulation of data processing circuit unit, data acquisition unit is connected with data processing unit, data processing unit is connected with data output unit, control unit again, and described data acquisition unit becomes the manageable digital signal of data processing unit with the analog signal conversion of simulation of data processing circuit unit collection; Data processing unit is processed the pulse wave signal of data acquisition unit output, calculates blood pressure values, to the output of data output unit, has simultaneously the function that sends instruction to control unit; Control unit offers data processing unit with measurement result, is used for calibration; The data output unit is with final pressure value and the pulse waveform output of data processing unit transmission.
3. ambulatory blood pressure measuring device as claimed in claim 2, is characterized in that: described data acquisition unit employing AD converter.
4. ambulatory blood pressure measuring device as claimed in claim 2, is characterized in that: described data output unit employing LCD liquid crystal display screen.
5. ambulatory blood pressure measuring device as claimed in claim 1 is characterized in that: described pulse wave acquisition probe adopts pulse wave sensor, is output as ultra-weak electronic signal.
6. ambulatory blood pressure measuring device as claimed in claim 5 is characterized in that: described pulse wave sensor adopts the difference pulse wave sensor of two collection points.
7. ambulatory blood pressure measuring device as claimed in claim 1, it is characterized in that: described data processing unit directly is plugged on described ambulatory blood pressure machine main part.
8. based on the ambulatory blood pressure measuring method of left and right brachial pulse ripple transmission time difference, it is characterized in that carrying out as follows:
At first, the pulse wave wave sensor is attached at left and right arms brachial artery place, sampling left and right arms brachial pulse ripple signal converts numerical signal to through A/D;
Then, judge whether it is to use for the first time, if begin calibration process: utilize blood pressure measuring to take blood pressure, record successively first feature blood pressure, second feature blood pressure, then enter and wait for and read the A/D transformation result; If not, wait for and read the A/D transformation result;
After waiting for and read the A/D transformation result, carry out successively data filtering, calculate phase contrast, calculating blood pressure, system filter;
Then, judge whether the protocols having request, if, request data output, then enter pulse wave, blood pressure, pulse frequency output and show; If not, enter pulse wave, blood pressure, pulse frequency output and demonstration;
At last, be back to and wait for and read the A/D transformation result.
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CN107184194A (en) * 2017-07-06 2017-09-22 中国科学院合肥物质科学研究院 Based on numerically controlled blood pressure self-operated measuring unit and method
CN109549639A (en) * 2017-09-26 2019-04-02 郑昕 A kind of pulse wave pressure and blood pressure measurement device and measurement method
CN109872820A (en) * 2019-03-29 2019-06-11 广州视源电子科技股份有限公司 A kind of no cuff blood pressure measuring method, device, equipment and storage medium
CN109893110A (en) * 2019-03-06 2019-06-18 深圳市理邦精密仪器股份有限公司 A kind of method and device for calibrating ambulatory blood pressure
CN110367959A (en) * 2019-07-18 2019-10-25 上海海事大学 A kind of blood pressure measuring device based on pulse wave phase difference and pulse wave characteristic parameters
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