CN103083490A - Traditional Chinese medicine for treating post-traumatic brain syndrome - Google Patents
Traditional Chinese medicine for treating post-traumatic brain syndrome Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine for treating post-traumatic brain syndrome. The traditional Chinese medicine is prepared from 8-18 parts of rehmannia glutinosa, 3-6 parts of deer-horn glue, 8-18 parts of angelica sinensis, 5-15 parts of dried body of ground beetle, 6-10 parts of arisaema cum bile, 6-15 parts of peach kernel, 6-15 parts of flowers carthami, 5-10 parts of ligusticum wallichii, 6-12 parts of root of common peony, 6-12 parts of radix bupleuri, 5-10 parts of platycodon grandiflorum, 6-15 parts of radix achyranthis bidentatae, 5-10 parts of fructus aurantii, and 6-12 parts of thyme. The traditional Chinese medicine has the characteristics of scientific collocation according to the traditional medicine theory in traditional Chinese medical science, supplements with each other, strengthens the brain, and promotes blood circulation to remove blood stasis.
Description
Technical field
The invention belongs to technical field of Chinese medicines, especially relate to a kind of Chinese medicine for the treatment of cerebral trauma sequela.
Background technology
Cerebral trauma sequela is again postcerebral injury syndrome (post-traumatic brain syndrome), refers to patient with brain trauma after convalescent period, long-standing one group of autonomic nervous function imbalance or spirituality symptom.Comprise the symptoms such as hemiplegia, headache, nervousness, irritability, the concentrated obstacle of attention, memory disorder, dizziness, insomnia, fatigue.And neurologic check there is no extremely, and the neuroradiology inspection is also found without positive.The feature main manifestations of postcerebral injury syndrome has four kinds: hemiplegia, headache, giddy and nervous system function obstacle three aspects:.The most common is hemiplegia, and a side limb activity is dumb.Next is headache, the head distending pain is often arranged, isolate sense or the sensation of jumping pain, and duration of seizure is indefinite, can be because of insomnia, tired, mind is not good enough, the smooth or not extraneous clamour of work is aggravated; Be dizzy again, patient often feels that head is muddy, thinking is clear not, or the dimmed sensation of a kind of confusion; In addition, patient also often is in a bad mood, and unstable, easily tired, insomnia, attention are laxed, hypomnesis, even being happy and angry uncertainly, emotional.Between or during autonomic nervous dysfunction, the symptoms such as tinnitus, cardiopalmus, fluctuation of blood pressure, hyperhidrosis, sexual disorder or menoxenia can appear in patient.At present postcerebral injury syndrome is without the specific treatment method, and mainly with acupuncture, Chinese medicine, and Western medicine symptomatic treatment, therapeutic effect is also undesirable.
Summary of the invention
The object of the invention is to improve the deficiency of prior art and provide a kind of according to the medication of traditional Chinese medical science tradition is theoretical, science is arranged in pairs or groups, complement each other, the Chinese medicine of the treatment cerebral trauma sequela of beneficial first brain-strengthening, blood circulation promoting and blood stasis dispelling.
The object of the present invention is achieved like this, a kind of Chinese medicine for the treatment of cerebral trauma sequela is comprised of the Radix Rehmanniae Preparata of weight portion 8-18 part, the Colla cornus cervi of 3-6 part, the Radix Angelicae Sinensis of 8-18 part, the eupolyphaga of 5-15 part, the Arisaema Cum Bile of 6-10 part, the Semen Persicae of 6-15 part, the Flos Carthami of 6-15 part, the Rhizoma Chuanxiong of 5-10 part, the Radix Paeoniae Rubra of 6-12 part, the Radix Bupleuri of 6-12 part, the Radix Platycodonis of 5-10, the Radix Achyranthis Bidentatae of 6-15 part, the Fructus Aurantii of 5-10 part, the Herba thymi vulgaris of 6-12 part.
The pharmacology that the present invention treats cerebral trauma sequela be basic theories take Chinese Chinese Traditional Medicine as the basis, the first flourish brain of benefit, life essence-filling, marrow-benefitting, blood circulation promoting and blood stasis dispelling is had one's ideas straightened out and is promoted blood circulation, remedying defects and rectifying errors complements each other.
Radix Rehmanniae Preparata: sweet in the mouth, warm in nature; Return liver, kidney channel.Has the yin nourishing of enriching blood, the effect of life essence-filling, marrow-benefitting.
Colla cornus cervi: sweet-salty, warm in nature; Return liver, kidney channel.Have enrich blood, the benefit essence effect.
Radix Angelicae Sinensis: sweet in the mouth, suffering, property is flat; Return liver, the heart, spleen channel.Having enriches blood invigorates blood circulation, the effect of menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Eupolyphaga: salty in the mouth, cold in nature; Return Liver Channel.Effect with removing blood stasis, reunion of fractured tendons and bones.
Arisaema Cum Bile: bitter in the mouth, little suffering, cold; Return lung, liver, spleen channel.Have removing heat-phlegm, the effect of the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc.
Semen Persicae: bitter in the mouth, sweet, property is flat; GUIXIN, liver, large intestine channel.Effect with blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, relieving cough and asthma.
Flos Carthami: acrid in the mouth, warm in nature; GUIXIN, Liver Channel.Effect with promoting blood circulation to restore menstrual flow, stasis-dispelling and pain-killing.
Rhizoma Chuanxiong: acrid in the mouth, warm in nature; Return liver, gallbladder, pericardium channel.Effect with blood-activating and qi-promoting, wind-expelling pain-stopping.
Radix Paeoniae Rubra: bitter in the mouth, cold nature; Return Liver Channel.Merit with clearing away heat and cooling blood, eliminating stasis to stop pain, clearing away liver-fire.
Radix Bupleuri: bitter in the mouth, suffering, cold nature; Return liver, gallbladder meridian.Merit with reducing fever by reconciliation, dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang.
Radix Platycodonis: acrid in the mouth, hardship, property is flat; Return lung meridian.Have the lung qi dispersing sore-throat relieving, the merit of the evacuation of pus of eliminating the phlegm.
Radix Achyranthis Bidentatae: bitter in the mouth, acid, property is flat; Return liver, kidney channel.Merit with promoting blood circulation to restore menstrual flow, relieving stranguria by diuresis, conducting blood to flow downwards, invigorating the liver and kidney, bone and muscle strengthening.
Fructus Aurantii: bitter in the mouth, suffering, acid, warm in nature; Return spleen, stomach, large intestine channel.Merit with regulating the flow of QI to ease the stomach, the stagnant relieving distension of row.
Herba thymi vulgaris: acrid in the mouth, warm in nature, slightly poisonous; Return lung, spleen channel.Has warming spleen and stomach for dispelling cold, the merit of wind-expelling pain-stopping.
Its prescription pharmacology is: the Radix Rehmanniae Preparata yin nourishing of enriching blood, and life essence-filling, marrow-benefitting, Colla cornus cervi is salty sweet and warm, and large complement is cloudy, and two medicines and Radix Angelicae Sinensis be 5 beneficial first flourish brains mutually, life essence-filling, marrow-benefitting; The Herba thymi vulgaris causing resuscitation with aromatic drugs, the Arisaema Cum Bile waking up the patient from unconsciousness by dissipating phlegm, two medicines phases 5 are played the merit of refreshment Fructus Alpiniae Oxyphyllae altogether; Decoction for removing blood stasis (Semen Persicae, Flos Carthami, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Radix Paeoniae Rubra, Radix Bupleuri, Radix Platycodonis, Radix Achyranthis Bidentatae, Fructus Aurantii) tonify deficiency blood stasis dispelling is promoted blood circulation with eupolyphaga phase 5 blood circulation promoting and blood stasis dispelling; All medicines share, and have the effect of " benefit first flourish brain, blood circulation and removing stasis, eliminate phlegm for resuscitation "; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription must be supported brains, and brain is full, and meridians are unobstructed, and the expectorant stagnation resolvation is loose, and all disease knowing are removed.
The present invention is made by the traditional Chinese herbal medicine of China, and the pathological characteristic according to cerebral trauma sequela develops.The basic reason of cerebral trauma sequela is that the damage of brain causes the movable abnormal and paralysis such as spirit, consciousness, thinking, language, vision " shrewdnesses ".Its feature main manifestations has four kinds: paralysis, headache, giddy and nervous system function obstacle four aspects.
Prescription of the present invention is to tackle the problem at its root to the effect of this disease, the benefit first flourish brain, blood circulation and removing stasis, eliminate phlegm for resuscitation.Benefit unit is that marrow is given birth in replenishing essence, and essence is filled out marrow and given birth to brain and filled and moisten, and astute activity is recovered, and the expectorant stagnation resolvation is loose, and the unobstructed limbs of meridians reactivate.Three months is a course for the treatment of, and take effect a general course for the treatment of, and three courses for the treatment of are visible obviously improves, six the course for the treatment of function substantially recover or fully recover.
The present invention is oral medicine, have no side effect, medication for many years, the patient is without any untoward reaction, follow the tracks of blood test normal, and curative effect do not rebound.
The animal toxicology experiment summary of Chinese medicine of the present invention: purpose is for observing the acute and long term toxicity effect of rat this prescription for oral administration.Method: it is study subject that the SD rat is arranged, take 4 dosage (40,20,10,5ml/kg), gave decoction 540 days for oral administration continuously, observe the growth promoter, blood, blood biochemical of administration rat in the time of 90-540 days, and after drug withdrawal 30-180 days, rat body weight, food ration, activity, peripheral hemogram, important organ coefficient are all normal.The biochemical analysis index: each administration group is with the contrast of blank group, and albumin reduces (P＞0.05), and total protein and creatinine raise (P＞0.05), alkali phosphatase (ALP) rising (P＞0.05).The conclusions chronic toxicological experiment represents: in this prescription medication process for oral administration, the observation of indices reaction has no obvious toxic-side effects.Analysis-by-synthesis is thought: this prescription is under prescribed dose, and application is safe and reliable.
Prescription of the present invention, no matter multiple patient, medication obviously took effect in three months.Headache, dizzy person can cure substantially, and side limbs are paralysed fully recovers a part of joint motion, and limb activity is inflexible freely movable.Realize re-set target general 3～6 courses for the treatment of.
Adopt Chinese medicine clinical practice of the present invention treatment 100 routine patients, treatment group 100 examples use that this prescription is dialectical to be treated, every day potion, decocting 200-250ml is divided into 2 minutes, each portion is oral sooner or later.Matched group 100 examples adopt the intramuscular injection of citicoline sodium injection, every day 1 time, and each 200mg～250mg, Cerebrolysin Vial 40-80mg intravenous drip, once a day.No matter total effective rate and obvious effective rate, treatment group is compared with matched group, significant difference.Learn by statistics unity and coherence in writing and process P＜0.05; The total effective rate treatment group is 98%, and matched group is 81%; The obvious effective rate treatment group is 81%, and matched group is 60%.Following table is the therapeutic evaluation after treatment group and treatment of control group:
_________________
The dead total effective rate of group number of cases produce effects enabledisable
_________________
Treatment group 100 81 17 30 98%
Matched group 100 60 21 19 0 81%
_________________
P＜0.05。
Specific embodiments
Below in conjunction with embodiment, the present invention is described in further detail.
Embodiment 1, a kind of Chinese medicine for the treatment of cerebral trauma sequela is comprised of Radix Rehmanniae Preparata 12 grams, Colla cornus cervi 6 grams, Radix Angelicae Sinensis 12 grams, eupolyphaga 15 grams, Arisaema Cum Bile 10 grams, Semen Persicae 10 grams, Flos Carthami 10 grams, Rhizoma Chuanxiong 10 grams, Radix Paeoniae Rubra 12 grams, Radix Bupleuri 12 grams, Radix Platycodonis 10 grams, Radix Achyranthis Bidentatae 15 grams, Fructus Aurantii 10 grams, Herba thymi vulgaris 12 grams.
Embodiment 2, a kind of Chinese medicine for the treatment of cerebral trauma sequela is comprised of Radix Rehmanniae Preparata 15 grams, Colla cornus cervi 9 grams, Radix Angelicae Sinensis 10 grams, eupolyphaga 15 grams, Arisaema Cum Bile 10 grams, Semen Persicae 10 grams, Flos Carthami 10 grams, Rhizoma Chuanxiong 10 grams, Radix Paeoniae Rubra 12 grams, Radix Bupleuri 12 grams, Radix Platycodonis 10 grams, Radix Achyranthis Bidentatae 20 grams, Fructus Aurantii 10 grams, Herba thymi vulgaris 15 grams.
Embodiment 3, a kind of Chinese medicine for the treatment of cerebral trauma sequela is comprised of Radix Rehmanniae Preparata 15 grams, Colla cornus cervi 9 grams, Radix Angelicae Sinensis 20 grams, eupolyphaga 20 grams, Arisaema Cum Bile 10 grams, Semen Persicae 12 grams, Flos Carthami 12 grams, Rhizoma Chuanxiong 12 grams, Radix Paeoniae Rubra 12 grams, Radix Bupleuri 12 grams, Radix Platycodonis 10 grams, Radix Achyranthis Bidentatae 30 grams, Fructus Aurantii 10 grams, Herba thymi vulgaris 12 grams.
Embodiment 4, a kind of Chinese medicine for the treatment of cerebral trauma sequela is comprised of Radix Rehmanniae Preparata 10 grams, Colla cornus cervi 6 grams, Radix Angelicae Sinensis 10 grams, eupolyphaga 10 grams, Arisaema Cum Bile 12 grams, Semen Persicae 10 grams, Flos Carthami 10 grams, Rhizoma Chuanxiong 12 grams, Radix Paeoniae Rubra 15 grams, Radix Bupleuri 12 grams, Radix Platycodonis 10 grams, Radix Achyranthis Bidentatae 30 grams, Fructus Aurantii 10 grams, Herba thymi vulgaris 15 grams.
Embodiment 5, a kind of Chinese medicine for the treatment of cerebral trauma sequela is comprised of Radix Rehmanniae Preparata 30 grams, Colla cornus cervi 12 grams, Radix Angelicae Sinensis 15 grams, eupolyphaga 15 grams, Arisaema Cum Bile 10 grams, Semen Persicae 12 grams, Flos Carthami 12 grams, Rhizoma Chuanxiong 15 grams, Radix Paeoniae Rubra 20 grams, Radix Bupleuri 12 grams, Radix Platycodonis 10 grams, Radix Achyranthis Bidentatae 30 grams, Fructus Aurantii 10 grams, Herba thymi vulgaris 12 grams.
Concrete case:
Liu so-and-so, the man, 24 years old, mouth people from village, pavilion, cities and towns sent out in Haiyang county.The patient by the car head of wounding, caused the right side limb activity malfunctioning before 3 years, dysphonia, and thinking is discontinuous, gives an irrelevant answer.Check as seen: absentminded, the language question and answer is discontinuous, the damaged depression of the visible approximately 6*7*7 of right side of head temporal bone centimetre, facial hemiparalysis, right side upper and lower extremities muscular strength is the III level approximately, muscular hypertonia, biceps brachii m. tendon hyperreflexia, the walking of can not leaving the bed.Give beneficial first Huoxue Decoction 3 courses for the treatment of, spirit, mind, thinking, language are walked as usual all as ordinary person, and memory is front the raising, and headache, dizziness are known and removed.
Lee so-and-so, female, 17 years old, Laiyang City cave, Shandong Province mill people from town.By the automobile head of wounding, caused the right side limb activity ineffective before 2 years, facial hemiparalysis, the time send out severe headache.Check as seen: lassitude, pale complexion, the right side limb activity is ineffective, and right side upper and lower extremities muscular strength is the III level approximately, muscular hypertonia, knee jerk is hyperfunction, and language still can.Give beneficial first blood activating decoction, every day potion, twice sub-service.During to the 4th course for the treatment of, patient can walk with descending, still keeps the former method treatment of former side, to the 5th course for the treatment of, recovers as usual, headache recovery from illness during the 6th course for the treatment of.
Claims (1)
1. a Chinese medicine for the treatment of cerebral trauma sequela, is characterized in that being comprised of the Radix Rehmanniae Preparata of weight portion 8-18 part, the Colla cornus cervi of 3-6 part, the Radix Angelicae Sinensis of 8-18 part, the eupolyphaga of 5-15 part, the Arisaema Cum Bile of 6-10 part, the Semen Persicae of 6-15 part, the Flos Carthami of 6-15 part, the Rhizoma Chuanxiong of 5-10 part, the Radix Paeoniae Rubra of 6-12 part, the Radix Bupleuri of 6-12 part, the Radix Platycodonis of 5-10, the Radix Achyranthis Bidentatae of 6-15 part, the Fructus Aurantii of 5-10 part, the Herba thymi vulgaris of 6-12 part.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770501A (en) * | 2016-05-18 | 2016-07-20 | 高福源 | Traditional Chinese medicine capsule for treating post-traumatic brain syndrome and preparation method of traditional Chinese medicine capsule |
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| CN105770501A (en) * | 2016-05-18 | 2016-07-20 | 高福源 | Traditional Chinese medicine capsule for treating post-traumatic brain syndrome and preparation method of traditional Chinese medicine capsule |
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Application publication date: 20130508 |