CN103071150B - Chinese patent medicine for treating Alzheimer's disease - Google Patents

Abstract

According to the traditional Chinese medical science, spleen and kidney deficiency, dull expression, slow motion, immobility with few words all day, silly crying and giggling, eating and living inability, and empty brain are the basic pathological changes of the Alzheimer's disease, kidney essence deficiency is the basic pathogenesis, and phlegm coagulation and blood stasis promote the development of the Alzheimer's disease. The Chinese patent medicine treats the Alzheimer's disease through kidney tonifying, essence replenishing, phlegm reducing and blood circulation invigorating, and mainly comprises 30% of Manyprickle Acathopanax Root, 16% of Cistanche deserticola, 10% of Chinese magnoliavine, 8% of Polygonatum sibiricum, 8% of epimedium, 8% of Crocus sativus, 3% of salidroside, 3% of total saponins of panax notoginseseng, 2% of polygalic acid, 2% of lycopene, 2% of total saponins of ginseng, 2% of saponins of Radix Astragali, 2% of hirudin, 1.5% of idebenone, 1.5% of vitamin B12, and 1% of ferulic acid. The above sixteen medicines undergo ultrafine crushing according to proportions, and are uniformly stirred to prepare an electuary, and 2g of the electuary is continuously taken three times a day after meals for 9-12 weeks.

Description

A kind of Chinese patent medicine for the treatment of alzheimer's disease

One, technical field:

The invention belongs to medical technical field, relate to a kind of compound granules, refer to more specifically a kind of compound granules of preventing and treating alzheimer's disease.

Two, background technology:

Alzheimer's disease is common senile chronic disease, and current commercially available relevant medicine is poor effect all, or is difficult to fundamentally prevent and treat alzheimer's disease, and the present invention adopts Traditional Chinese medical theory monarch, the mutually auxiliary theoretical control alzheimer's disease of negative and positive.

Three, summary of the invention:

Alzheimer's disease is common senile chronic disease, differential diagnosis in tcm, and spleen deficiency of the kidney is damaged, witless expression, is slow in action, even keeping silence all day with no speaking, stupidly cry and laugh foolishly, daily life diet all needs people to look after, and brains inanition is that the basic pathology of alzheimer's disease changes, deficiency of kidney-essence is basic pathogenesis, the expectorant blood coagulation stasis of blood has promoted the development of alzheimer's disease, and the present invention controls from void opinion, kidney tonifying, essence replenishing, reduce phlegm and invigorate blood circulation as starting point treatment alzheimer's disease, main component and proportioning are as follows:

Radix Et Caulis Acanthopanacis Senticosi: another name Cortex Acanthopancis, thorn bent stick (Northeast China), Araliaceae Acanthopanax, the main component of Radix Et Caulis Acanthopanacis Senticosi is Radix Et Caulis Acanthopanacis Senticosi glucoside, the molecular formula C of Radix Et Caulis Acanthopanacis Senticosi glucoside ₁₇h ₂₄o ₉, Radix Et Caulis Acanthopanacis Senticosi glucoside has blood vessel dilating, reduces blood pressure, anti-platelet aggregation, improve hemorheological characteristics and improve microcirculation; It can stimulate mind & body vigor, and it has antifatigue effect, strengthens endurance and ability, increases alertness and learning capacity; There is to excited and inhibition two-ways regulation in function of nervous system; There is calmness, suppress spontaneous activity, hypnosis, convulsion; Cure of depression, cerebral thrombosis.Replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization; The Senile disease such as, inappetence weak for deficiency of spleen-YANG and kidneyYANG, body void, soreness of waist and knee joint, insomnia and dreamful sleep.This medicine is monarch drug of the present invention.

Herba Cistanches: another name Herba Cistanches, the fleshy stem of Orobanchaceae plant; Herba Cistanches is containing number of chemical composition, and Herba Cistanches contains the compositions such as abundant alkaloid, crystalline neutral substance, aminoacid, trace element, vitamin.Energy kidney-replenishing, benefiting essence-blood, can suppress the appearance of " yang deficiency " symptom, prevents from losing weight.Herba Cistanches is improving immunocompetence also.Herba Cistanches polysaccharides has significant impact to the formation of human lymphocyte and activity, and it can increase lymphocytic breeder reaction, thus the immunologic function of enhancing body.Herba Cistanches is scalable blood circulation also, has protection ischemic myocardium, blood fat reducing, and atherosclerosis, antithrombotic form; Reduce peripheral vascular resistance, expansion peripheral blood vessel, reduces blood pressure; The liver protecting, anti-fatty liver.The bright alcohol sugar of benzene contained in Herba Cistanches is the unexistent composition of other drug, and it is the most effective composition of slow down aging.Herba Cistanches all has obvious retarding action to the positions such as hypophysis cerebri, gonad, thymus under human body aging.

Fructus Schisandrae Chinensis: Magnoliaceae, Schizandra.< < herbal classic > >: main QI invigorating, cough with dyspnea, the thin degree of impairment caused by overstrain, tonifying for the deficiency, reinforcing YIN-essence.Main chemical compositions schizandrin (schizandrin).Fructus Schisandrae Chinensis contains abundant organic acid, vitamin, flavonoid, phytosterol and has the lignan of potent reactivation, it is also one of minority medical material having concurrently essence, gas, god's three large tonifications, the strong liver of energy QI invigorating, the efficiency of promoting cells exclude refuse, supply more oxygen, construction and uses energy, raising memory and property endurance.In ancient times, Russian hunter must take Fructus Schisandrae Chinensis to keep fit QI invigorating before going on a long journey at every turn and hunting.Fructus Schisandrae Chinensis can activate nervous system, promote respond, concentrate power and coordinative role, and it is clear to strengthen thinking.Although it has the effect of activation, there is no caffeine side effect restless.This slight berry, is also used to treat melancholia sometimes, and helps improvement agitation and forgetful problem.Strengthen device endurance research report and show, Fructus Schisandrae Chinensis is often used as the tonic of aging resistance and QI invigorating, and recent result of study has more been illustrated this principle.Research discovery, the contained lignan of Fructus Schisandrae Chinensis can strengthen the energy production of adenosine triphyosphate (ATP) or mitochondrion (cellular energy storehouse), and the line body of protection is simultaneously avoided oxidative pressure and is encroached on.Why these effects are enough to illustrate that Fructus Schisandrae Chinensis can slow down ageing process and delay to occur ageing-related disease, as heart failure, Alzheimer disease and Parkinson's disease.Above-mentioned two taste medicines are ministerial drug of the present invention.

Rhizoma Polygonati: have another name called Rhizoma Polygonati Cirrhifolii, Caput Gallus domesticus ginseng.Boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying, Rhizoma Polygonati has blood pressure lowering, blood sugar lowering, blood fat reducing, atherosclerosis, slow down aging and the effect such as antibacterial, polygonatum polysaccharide has Immunestimulatory effect.For lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, and the chronic cough chronic cough of YIN-deficiency of the lung and kidney etc.For weakness of the spleen and stomach.Both tonifying spleen-yin, strengthening the spleen gas again, for deficiency of kidney essence, soreness of the waist and knees, has important auxiliary therapeutic action to alzheimer's disease.

Herba Epimedii: mainly containing flavone compound, lignanoid, alkaloid, volatilization wet goods. in the plants such as Herba Epimedii, contain ceryl alcohol (Ceryl alcohol), 1 alkane (Hentriacontane), plant sterol (Phytosterol), Palmic acid (Palmitic acid), stearic acid (Stearic acid), oleic acid (Oleic acid), linoleic acid (Linoleic acid), linolenic acid (Linolenic acid), ginnol (Bilobanol), magnoline (Magnoflorin), glucose (Glucose), fructose (Fructose), vitamin E etc.Can improve body's immunity; Can expand all blood vessels, improve microcirculation, increase blood flow, increase coronary flow; Have antitussive, eliminate the phlegm, anti-hypoxia, calmness, anticonvulsant action, for insufficiency of kidney-YANG, sexual impotence frequent micturition; Rheumatic arthralgia, numb limbs and tense tendons contracture, muscles and bones flaccidity is soft, walks with difficulty; Insufficiency of kidney-YANG, breathes with cough and loses heart.

Stigma Croci, main component is picrocrocin (C ₁6H ₂6O ₇).Coloring material is crocin (C ₄₄h6 ₄o ₂6H ₂o).Chemical composition is containing crocin-1,2,3,4 (crocin-1～4), picrocrocin (picrocrocin), bayer acid dimethyl ester (crocetindimethyl ester), α-bayer acid (a-crocetin) safranal (safranal), volatilization wet goods.Have, immunoregulation effect, Stigma Croci is used for the treatment of the multiple chronic disease of human body clinically, by the effect of its blood circulation promoting and blood stasis dispelling, anti-inflammation, enhancing body endurance, strengthens lymphproliferation response, with this, improves Cellular Immunity and humoral immunization, play human functional activity of vital energy operation, the effect of balance yin-Yang adjusted.

Rhodioside: molecular formula C ₁₄h ₂oO ₇there is enhancing immunity, eliminate melancholy sense, protection cardiovascular.

Radix Notoginseng total arasaponins: molecular formula C ₄₇h8oO ₁₇cure mainly blood circulation promoting and blood stasis dispelling, promote blood circulation active.There is the effect of anticoagulant and increase cerebral blood flow, for cerebrovascular sequelae, central retinal vein occlusion etc.Above-mentioned five kinds of Chinese medicine is adjuvant drug of the present invention.

Polygalacic acid: molecular formula C ₃oH ₄8O6 has stronger phlegm-dispelling functions; The dead drunk enzyme of cyclic adenosine monophosphate di(2-ethylhexyl)phosphate is had to inhibitory action; Energy physical strength reinforcing and intelligence; There is stronger haemolysis, aldehyde ketone reductase is had to inhibitory action.In addition also have the effects such as mutation, anticancer, calm, convulsion, edema and diuresis.

Lycopene: its molecular formula is C ₄oH ₅6 can prevent and suppress cancer, protection cardiovascular, and slow down aging, enhancing immunity: lycopene can be removed the free radical in human body most effectively, keep cell homergy, anti-aging in advance.Lycopene is absorbed and is entered blood and lymph by gastrointestinal mucosal in vivo, be distributed to testis, adrenal gland, prostate, pancreas, breast, ovary, liver, lung, colon, skin and various mucosal tissue, promote glandular secretion hormone, thereby make human body keep vigorous energy; Remove the free radical in these Organ and tissues, protect them to escape injury, enhancing human body immunity power.

Radix Ginseng total glycosides: Araliaceae, the extract of Radix Ginseng, be rich in 18 kinds of Saponins, can obviously suppress cylinder super-oxidation lipid and form, increase the content of Superoxide dismutase and peroxidase simultaneously, there is antioxidation, reduce interior free yl content, increase human body cell vigor, suppress old and feeble, reduce blood glucose.

Radix Astragali saponin: leguminous plant, the extract of the root of the Radix Astragali, containing flavones ingredient, calycosin, 3-hydroxy-9,10-dimethoxy pterocarpane, Radix Astragali saponin I, V, III, energy tonifying Qi and lifting yang, benefit is defended consolidating superficial resistance, regulates human body metabolism, and enhancing immunity improves antioxidant ability of organism.

Hirudin: be mainly that separating-purifying out, has anticoagulant from the saliva of Hirudo, the peptide material of antithrombotic effect, the clinical treatment that is usually used in multiple thrombotic disease, can eliminate angiemphraxis, makes hemocyte depolymerization, thrombosis dissipates, and promotes blood capillary logical again, improves microcirculating state.At present, be usually used in regulating blood fat, eliminate fatty liver, directly dissolve thrombosis, eliminate atherosclerosis, prevent apoplexy and apoplexy again, the thrombolytic function of human activin self, avoids again producing thrombolytic etc., to treating alzheimer's disease, also has effect.

Idebenone: molecular formula C ₁₉h ₃oO ₅this medicine is that brain metabolism, mental symptom are improved medicine, can activate brain mitochondria respiratory activity, improves the brain energy metabolism of cerebral ischemia, improves glucose utilization rate in brain, makes ATP in brain produce increase.Idebenone is that the specific drug of novel anti-alzheimer's disease and brain function metabolism and mental symptom are improved medicine.The patients such as clinical, emotionally disturbed low for disordered brain function, consciousness, aphasis, dementia.

Ferulic acid: the chemical name of ferulic acid (Ferulic Acid) is 4 hydroxyl 3 methoxy cinnamic acids is one of derivants of cinnamic acid (claiming again cinnamic acid, 3 phenyl 2 acrylic acid).Ferulic acid has sedation, and ferulic acid has spasmolytic effect to smooth muscle, can increase cerebral blood flow.

Vitamin B12: molecular formula C6 ₃h88CoN ₁₄o ₁₄p eliminates dysphoria, focuses one's attention on, and hypermnesis and equilibrium sense are that nervous function perfects indispensable vitamin, participates in the formation of a kind of lipoprotein in nervous tissue, safeguards metabolism and the function of neural myelin.B is deficient in vitamin ₁₂time, neurological disorder, spinal cord degeneration can be caused, and serious mental symptom can be caused.Vitamin B ₁₂shortage can cause peripheral neuritis.B is deficient in vitamin ₁₂early manifestation be mood disorders, have a dull expression on one's face, bradykinesia.

Vitamin B in old people colony ₁₂the phenomenon of level deficiency is very general, should note supplementing in time, otherwise can reduce cognitive competence, accelerates the development of senile dementia.

Above-mentioned 16 kinds of medicines, by proportioning superfine grinding, uniform stirring is made electuary, each serving with 2 grams, every day three times, uses after meal warm boiled water, serve on 9～12 weeks.

Four, the specific embodiment:

The present invention uses more than 20 routine alzheimer's diseases, and each oral 2 grams of early stage patient, every day three times, serve on 9～12 weeks with warm boiled water after meal, and hands limb chatter symptom takes a turn for the better, and linguistic competence strengthens, and memory is recovered, and quality of life obviously improves.

Claims (1)

1. treat a Chinese patent medicine for alzheimer's disease, the one-tenth that it is characterized in that it be grouped into and proportioning as follows:

Above-mentioned 16 kinds of medicines, by proportioning superfine grinding, uniform stirring is made electuary, each serving with 2 grams, every day three times, uses after meal warm boiled water, serve on 9～12 weeks.