CN103065054A - Method for processing radiotherapy precision data on basis of probability safety analysis - Google Patents
Method for processing radiotherapy precision data on basis of probability safety analysis Download PDFInfo
- Publication number
- CN103065054A CN103065054A CN2013100135536A CN201310013553A CN103065054A CN 103065054 A CN103065054 A CN 103065054A CN 2013100135536 A CN2013100135536 A CN 2013100135536A CN 201310013553 A CN201310013553 A CN 201310013553A CN 103065054 A CN103065054 A CN 103065054A
- Authority
- CN
- China
- Prior art keywords
- event
- probability
- data
- accuracy
- radiotherapy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Radiation-Therapy Devices (AREA)
Abstract
The invention relates to a method for processing radiotherapy precision data on the basis of probability safety analysis. The method is used for implementing a probability safety analysis process in a precision radiotherapy system. The method is characterized in that causal connection among various parameters with key influence to the precision of precision radiotherapy is analyzed by a process for analyzing the data in the probability safety analysis, the probability of precision failure is analyzed by modeling for processing the data, influence of various systems and human factors to the precision is evaluated, key problems are found out, key deviation is corrected, and accordingly the quality of precision radiotherapy is improved.
Description
Technical field
The present invention relates to the technical field of probabilistic safety analysis, be specifically related to a kind of radiotherapy accuracy data analysing method of Based on Probability safety analysis, it is applied to analysis of complex system in the accurate radiotherapy with the data analysing method in the probabilistic safety analysis, utilize the accident sequence of the modeling pattern analysis accuracy failure of fault tree, the data that generate can be applied to the radiotherapy planning system, are used for assessment and analysis to put accurately penetrating property for the treatment of.
Background technology
Development along with medical physics and computer science, the radiation therapy accuracy requires more and more higher, but always there are some factors restricting the accuracy of the suitable shape of dosage or target area, such as target area location, treatment pendulum position, the different strong technology of accent and different operator etc., this has just caused radiocurable uncertainty, and namely accuracy may failure.Only limit to analysis to single factor for the as a result research of accuracy now, the different percentage errors that single factor is caused compare, thereby analyze and preferentially utilize.Yet radiation therapy process is multifactorial comprehensive, and the lower degree of accuracy size of a plurality of factor synergies there is no adaptable appraisal procedure.Having at present human probabilistic safety analysis method to analyze the accident that the dosage mistake occurs in the high dose rate afterloading radiotherapy, only is an event about mechanical safety in the internal-radiation therapy, is not suitable for external exposure, more can not reflect the radiotherapy accuracy.
At present there is for many years the probabilistic safety analysis method of operating experience to offer reference for above-mentioned multifactor collaborative evaluation at nuclear power station, the possibility indirect correlation connection that utilizes the analysis ratiocination method that is similar to fault tree that each step and last accident are occured.Be the corresponding relation that to set up cause and effect in the radiation therapy, and utilize the data of long-term accumulation, carry out the basis for analysis and prepare.The probabilistic safety assessment system that nuclear power station is generally used can not directly apply to the analysis of radiation therapy accuracy, and radiation therapy must be set up the data analysis pattern of oneself.This patent applied probability safety analytical method is analyzed the event occurrence rate of running counter to accuracy among the accurate radiotherapy result, and under this probability in the Patients During Radiotherapy each system to the contribution of accident, it is the analysis for accurate radiotherapy system irradiated region conformal degree and absorbed dose accuracy, be the result of each combined factors effect, can be used as accurate radiotherapy system comprehensive evaluation index.
Summary of the invention
This research method has been widened the range of application of probabilistic safety analysis method, and the systematic analysis approach of radiation therapy accuracy research is provided, and it is perspective as follows:
1, the probabilistic safety analysis method is mainly used at present nuclear power station, space industry etc. and relates to great safe event analysis as a kind of System Assessment Method of maturation.For the coefficient result of complication system, not necessarily relevant with safety, as long as conform with this kind method analysis principle and can the Realization analysis path, just can analyze by the applied probability safety analytical method, this patent has been demonstrated specific implementation process, the feasibility path is provided, has widened the range of application of this data analysing method of probabilistic safety analysis, will play a role in more areas.
2, the data and the treatment planning systems that generate is integrated, can reflect in real time degree of accuracy and afterwards evaluation, provide quantitative criteria for estimating degree of accuracy and radiotherapy scheme quality.Data can be used for separately estimating, also can unite with radiotherapy treatment planning system, with probabilistic safety analysis software and empirical design data as one of radiotherapy treatment planning system complementary subsystem, can automatically identify the primary event of current operation, the importance size that each essential planning design procedure is shown experience probability and this system can Real-Time Monitoring and checking radiation therapy implementation process accuracy.
The technical solution used in the present invention is: a kind of radiotherapy accuracy data processing method of Based on Probability safety analysis, with the event generating process of each step of radiation therapy process corresponding to complication system, set up fault tree models, utilize probabilistic safety analysis software to process probability data, thereby draw probability and each step importance size of accuracy failure, its step is as follows:
Step (1), utilize existing radiation therapy technology to collect primary data, the source data as in the probabilistic safety analysis method comprises: the error information of elementary event probability and probability, people are because of the relevant data of slipping up, data because being correlated with altogether;
Step (2), the radiation therapy accuracy is failed as top event, radiation therapy process is carried out the fault tree modeling, there are factors of crucial impact to be divided into dosage mistake, pendulum bit-errors, target area on radiation therapy all and delineate mistake, output error 4 large classes, each class is launched respectively, analyze all factors that directly cause its generation, until primary event; Top event, intermediate result, primary event are referred to as event, to occur separately just to cause the event of last layer event to use or the door connection, unite and occur just to cause the event of last layer event to be used with door and be connected, thereby all event chains can be connected into a fault tree;
Step (3), with each primary event probability data in the fault tree models and other source data input probability analysis software, system automatically calculates minimal cut set and carries out quantitative test, the result is used for assessment accuracy of electronic and importance analysis.
The present invention has very high directive significance and using value in radiotherapy degree of accuracy field, and its concrete using value is as follows:
1., the present invention can estimate different design alternative schemes;
2., the present invention can identify the shortcoming in the design;
3., the present invention can and improve and set up overall equilbrium between the degree of accuracy in the error prevention;
4., the present invention can be from probabilistic safety analysis angle recognition therapeutic process certain step importance;
5., the present invention can find out some relevant problems of human error.
Description of drawings
Fig. 1 is implementation process flow diagram of the present invention;
Fig. 2 is the modeling example.
Embodiment
As shown in Figure 1, a kind of radiotherapy accuracy data analysing method of Based on Probability safety analysis, implementation step is as follows:
(1) utilizes existing radiation therapy empirical data, perhaps simulated experiment data are collected primary data, source data as in the probabilistic safety analysis method comprises: the error information of elementary event probability and probability, people are because of the relevant data of slipping up, altogether because of relevant data;
(2) the radiation therapy accuracy is failed as top event, radiation therapy process is carried out the fault tree modeling, there are factors of crucial impact to be divided into dosage mistake, pendulum bit-errors, target area on radiation therapy all and delineate mistake, output error 4 large classes, each class is launched respectively, analyze all factors that directly cause its generation, until primary event, thereby all event chains can be connected into a fault tree;
(3) with each primary event probability data in the fault tree models and other source data input probability analysis software, system automatically calculates minimal cut set and carries out quantitative test, and the result is used for assessment accuracy of electronic and importance analysis.
Computation process is realized by probabilistic safety analysis software, asks top event probability of happening computing formula as follows:
In the formula: the sequence number of r, s, k-minimal cut set, r＜s＜k;
The built-up sequence of r, two cut sets of s in 1≤r＜s≤k-k minimal cut set;
x
i∈ E
r-belong to i elementary event of r minimal cut set;
x
i∈ E
r∪ E
s-belong to i elementary event of r or s minimal cut set;
The sequence number of i-elementary event;
q
iThe probability of happening of-elementary event.
Top event is defined as the accuracy failure, be final conformal degree or absorbed dose error rate〉± 5% for having lost accurate meaning, the fault tree trunk is main coarse factor that causes, track the primary event of whole radiotherapy system, for the primary event that certainly exists error, with error rate＞± 5% expression mistake, be correct in＜± 5% scope, and the logical relation between the use logic gate expression event, finally finish modeling.
The part that the present invention does not elaborate belongs to techniques well known.
Although the above is described the illustrative embodiment of the present invention; so that the technician of present technique neck understands the present invention; but should be clear; the invention is not restricted to the scope of embodiment; to those skilled in the art; as long as various variations appended claim limit and the spirit and scope of the present invention determined in, these variations are apparent, all utilize innovation and creation that the present invention conceives all at the row of protection.
Claims (2)
1. the radiotherapy accuracy data processing method of a Based on Probability safety analysis, it is characterized in that the event generating process of each step of radiation therapy process corresponding to complication system, set up fault tree models, utilize accuracy and each step importance size of probabilistic safety analysis software analysis radiotherapy in the treatment technology, its step is as follows:
Step (1), utilize existing radiation therapy technology to collect primary data, the source data as in the probabilistic safety analysis method comprises: the error information of elementary event probability and probability, people are because of the relevant data of slipping up, data because being correlated with altogether;
Step (2), the radiation therapy accuracy is failed as top event, radiation therapy process is carried out the fault tree modeling, there are factors of crucial impact to be divided into dosage mistake, pendulum bit-errors, target area on radiation therapy all and delineate mistake, output error 4 large classes, each class is launched respectively, analyze all factors that directly cause its generation, until primary event; Top event, intermediate result, primary event are referred to as event, to occur separately just to cause the event of last layer event to use or the door connection, unite and occur just to cause the event of last layer event to be used with door and be connected, thereby all event chains can be connected into a fault tree;
Step (3), with each primary event probability data in the fault tree models and other source data input probability analysis software, system automatically calculates minimal cut set and carries out quantitative test, the result is used for assessment accuracy of electronic and importance analysis.
2. the radiotherapy accuracy data processing method of a kind of Based on Probability safety analysis according to claim 1, it is characterized in that described radiation therapy process being carried out the fault tree modeling, top event is defined as the accuracy failure, be final conformal degree or absorbed dose error rate〉± 5% for having lost accurate meaning, the fault tree trunk is main coarse factor that causes, track the primary event of whole radiotherapy system, for the primary event that has error, just use error rate〉± 5% expression mistake, be correct less than this error, and the logical relation between the use logic gate expression event, finally finish modeling.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013100135536A CN103065054A (en) | 2013-01-14 | 2013-01-14 | Method for processing radiotherapy precision data on basis of probability safety analysis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2013100135536A CN103065054A (en) | 2013-01-14 | 2013-01-14 | Method for processing radiotherapy precision data on basis of probability safety analysis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103065054A true CN103065054A (en) | 2013-04-24 |
Family
ID=48107682
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2013100135536A Pending CN103065054A (en) | 2013-01-14 | 2013-01-14 | Method for processing radiotherapy precision data on basis of probability safety analysis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103065054A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108139724A (en) * | 2015-10-09 | 2018-06-08 | 费希尔-罗斯蒙特系统公司 | For creating the system and method for monitoring block and result set of blocks from causality matrix |
| CN110070269A (en) * | 2019-03-28 | 2019-07-30 | 中国辐射防护研究院 | A kind of management optimization method of equipment in the reprocessing facility of risk-informed |
| CN110175359A (en) * | 2019-04-23 | 2019-08-27 | 中国电子产品可靠性与环境试验研究所（（工业和信息化部电子第五研究所）（中国赛宝实验室）） | Complication system Safety Modeling Methods and device based on operation flow |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101185078A (en) * | 2005-05-20 | 2008-05-21 | 米哈伊尔伊夫金耶维奇·斐多索夫斯基 | Deterministic probabilistic safety analysis and evaluation method and system |
| KR20120105752A (en) * | 2011-03-16 | 2012-09-26 | 한국원자력연구원 | Psa model modification script of nuclear power plant and psa model mapping algorithm using thereof |
-
2013
- 2013-01-14 CN CN2013100135536A patent/CN103065054A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101185078A (en) * | 2005-05-20 | 2008-05-21 | 米哈伊尔伊夫金耶维奇·斐多索夫斯基 | Deterministic probabilistic safety analysis and evaluation method and system |
| KR20120105752A (en) * | 2011-03-16 | 2012-09-26 | 한국원자력연구원 | Psa model modification script of nuclear power plant and psa model mapping algorithm using thereof |
Non-Patent Citations (4)
| Title |
|---|
| 任春玲: "计算机辅助概率安全分析软件的设计与实现", 《中国优秀博硕士学位论文全文数据库(硕士)信息科技辑》 * |
| 安晶刚: "概率安全评价的方法及当前进展", 《中华放射医学与防护杂志》 * |
| 宋颖: "PET概率安全评价模式的建立以及风险控制措施的研究", 《中国优秀硕士学位论文全文数据库医药卫生科技辑》 * |
| 邓君: "后装治疗机概率安全评估模式的建立以及风险控制措施的研究", 《中国优秀硕士学位论文全文数据库医药卫生科技辑》 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108139724A (en) * | 2015-10-09 | 2018-06-08 | 费希尔-罗斯蒙特系统公司 | For creating the system and method for monitoring block and result set of blocks from causality matrix |
| US11073812B2 (en) | 2015-10-09 | 2021-07-27 | Fisher-Rosemount Systems, Inc. | System and method for creating a set of monitor and effect blocks from a cause and effect matrix |
| US11709472B2 (en) | 2015-10-09 | 2023-07-25 | Fisher-Rosemount Systems, Inc. | System and method for providing interlinked user interfaces corresponding to safety logic of a process control system |
| US11886159B2 (en) | 2015-10-09 | 2024-01-30 | Fisher-Rosemount Systems, Inc. | System and method for creating a set of monitor and effect blocks from a cause and effect matrix |
| CN110070269A (en) * | 2019-03-28 | 2019-07-30 | 中国辐射防护研究院 | A kind of management optimization method of equipment in the reprocessing facility of risk-informed |
| CN110070269B (en) * | 2019-03-28 | 2022-12-09 | 中国辐射防护研究院 | Management optimization method for equipment in post-processing facility based on risk guidance |
| CN110175359A (en) * | 2019-04-23 | 2019-08-27 | 中国电子产品可靠性与环境试验研究所（（工业和信息化部电子第五研究所）（中国赛宝实验室）） | Complication system Safety Modeling Methods and device based on operation flow |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Wang et al. | Seismic fragility analysis with artificial neural networks: Application to nuclear power plant equipment | |
| Bojechko et al. | A quantification of the effectiveness of EPID dosimetry and software‐based plan verification systems in detecting incidents in radiotherapy | |
| Glenn et al. | Treatment plan complexity does not predict IROC Houston anthropomorphic head and neck phantom performance | |
| Handsfield et al. | Phantomless patient‐specific TomoTherapy QA via delivery performance monitoring and a secondary Monte Carlo dose calculation | |
| Calvo‐Ortega et al. | A Varian DynaLog file‐based procedure for patient dose‐volume histogram‐based IMRT QA | |
| CN110841205B (en) | Accurate dose verification device for tumor patients | |
| Pennazio et al. | Carbon ions beam therapy monitoring with the INSIDE in-beam PET | |
| Matter et al. | Alternatives to patient specific verification measurements in proton therapy: a comparative experimental study with intentional errors | |
| Castiglia et al. | THERP and HEART integrated methodology for human error assessment | |
| US11975217B2 (en) | Computer-implemented method of evaluating a protocol for radiation therapy including a pre-treatment physics chart review (TPCR) | |
| Palaniswaamy et al. | A statistical approach to IMRT patient‐specific QA | |
| Hunt et al. | The impact of new technologies on radiation oncology events and trends in the past decade: an institutional experience | |
| CN110302475A (en) | A kind of cloud Monte Carlo dose verifying analysis method, equipment and storage medium | |
| CN103065054A (en) | Method for processing radiotherapy precision data on basis of probability safety analysis | |
| Lizar et al. | Patient-specific IMRT QA verification using machine learning and gamma radiomics | |
| Martins et al. | Optimization of Phase Space files from clinical linear accelerators | |
| Zhu et al. | Patient‐specific quality assurance prediction models based on machine learning for novel dual‐layered MLC linac | |
| Bowen et al. | Formal methods and software safety | |
| Yeh et al. | Monte Carlo evaluation of Acuros XB dose calculation Algorithm for intensity modulated radiation therapy of nasopharyngeal carcinoma | |
| Mihaylov et al. | Quantification of the impact of MLC modeling and tissue heterogeneities on dynamic IMRT dose calculations | |
| Chakarova et al. | An automated Monte Carlo QC system for volumetric modulated arc therapy: possibilities and challenges | |
| Noel et al. | Quality assurance with plan veto: Reincarnation of a record and verify system and its potential value | |
| Sands et al. | The utilisation of probabilistic risk assessment in radiation oncology | |
| Stevens et al. | IPEM topical report: guidance for the clinical implementation of online treatment monitoring solutions for IMRT/VMAT | |
| CN116808454A (en) | Radiotherapy equipment treatment evaluation system based on NLP |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20130424 |