The specific embodiment
Although used particular term in for the sake of clarity describing hereinafter, these terms only relate to the ad hoc structure for the selected embodiment of explanation accompanying drawing, not should be understood to for limiting or limiting the scope of the invention.At accompanying drawing with in hereinafter describing, be appreciated that same Reference numeral refers to same functional unit.
The modifier that is combined with quantity " approximately " comprises listed numerical value and has implication (for example, it comprises the degree of error relevant with the measurement of specific quantity at least) by the context appointment.
[definition of Essential Terms]
In order conveniently to understand the present invention, at first following term is provided and explains or definition:
Natural lens: refer to the natural lens in mankind's (or extensively referring to mammal) eyes.The natural lens outside is surrounded by the elastic membrane vesicle of one deck, also claims pouch.Mention among the present invention on the natural lens surface, refer on the membrane vesicle of natural lens front surface.Natural lens is transparent and can regulate focusing power, and it can make closely the object of (or far) distance drop on imaging on the retina.Since 40 years old, this adjusting focusing power of most people fell into a decline, and began to completely lose this adjusting focusing power to about 50 years old, Here it is our said presbyopia.
The said intraocular lens of the present invention also claims intra ocular diopter lens, dioptric lens, refers to that there are and work simultaneously to correct the optical glass of vision refractive error simultaneously in human (or the general reference mammal) ophthalmic of implantation and natural lens.Intraocular lens is comprised of an optical body and supporter.
Optical body: referring to the center ingredient of intra ocular diopter lens, can be biconvex mirror, biconcave mirror, concave mirror behind front recessed rear convex lens or the lordosis.Optical body is used for making incident beam to gather on the retina, and its diopter D commonly used represents.As ,-1D is exactly myopia 100 degree of often saying, and+1D is exactly hypermetropia 100 degree of often saying.
Supporter: also claim " button loop section ", it directly is connected with optical body, and the function that it does not provide dioptric to adjust, but regional for bearing optical is used for support of optical body desired center position in eye.Implant the intraocular lens of back room, after its optical zone is positioned at pupil, and supporter is positioned at the iris rear surface.
Cornea: the curved face type tissue of eyes transparent front.
Iris: the annular pigmented film of facies posterior corneae, central authorities are pupil.
Ciliary zonule: or be called for short small band, refer to be bonded at ciliary zonule around the natural lens equator.Also claim corpus ciliare.
Pupil (pupil): be the round defect of iris central part, can fall apart large and dwindle, enter what of eyeball with light regulating.
Camera oculi anterior: the locus between cornea and iris.
Camera oculi posterior: general reference is positioned at the locus of facies posterior iridis.In description of the present invention, often refer to be located at the locus of facies posterior iridis and natural lens front.Iris neither belongs to the anterior chamber, does not belong to again back room, but as the boundary of distinguishing forward and backward room.
Pocket knife otch: cataract operation surgeon Essential Terms.Refer generally on cornea or the about otch of 3 millimeters long of edge slit, one approximately the intraocular lens of 6 mm dias after folding, can implant this otch.This operation does not need suture in the ordinary course of things, and wound can spontaneous recovery.
Below, further describing with reference to the accompanying drawings technical scheme of the present invention, it is to consist of in order to help to understand the disclosed device of this paper that accompanying drawing is provided, more completely to understand the present invention.It only is for convenience of description that accompanying drawing is provided, and accompanying drawing is all indicative icon, therefore, is not intended the scope of relative size and size and/or restriction or the restriction embodiment of indicating device or its building block.
The explanation of describing about direction: the horizontal direction of mentioning in the literary composition or left and right directions, refer to the left and right directions of eyes or human eye, the above-below direction of mentioning in the literary composition refers to the above-below direction of eyes or human eye.
For conveniently understanding the present invention, provide accompanying drawing 10 at this, it illustrates typical eyeball sectional drawing.
10 introduce about normal aqueous humor circulating system with reference to the accompanying drawings.
The eye-chamber comprises anterior chamber 100, back room 110 and vitreous chamber 121 (wherein holding vitreous body 120).
Anterior chamber (anterior chamber) 100, be positioned at after the cornea 130, before the lesser ring of Merkel of iris 140 and crystalline lens 150, its periphery is called angle of anterior chamber 280 by the angle that limbus of corneae 160, corpus ciliare 170 and iris root form jointly, is the key position of aqueous humor circulation.
Back room (posterior chamber) 110 is positioned at after iris 140 and the pupil 180, the gap before crystalline lens 150 and Suspensory ligament and the ciliary processes.The prezone of back room is the pigment epithelium of facies posterior iridis; The circle, front side is iris and capsulociliary connecting portion; Side circle be have ciliary processes and prominent between recessed ciliary crown; Real rear boundary is limitans before the vitreous body.The volume of back room is narrow and small, and out-of-shape is by aqueous humor is filled.The size in back room gap is subjected to the impact of Accommodation (accommodation) factor, and when eye used adjusting, crystalline lens 150 is projection forward, and back room 110 namely narrows down; Regulating under the static state, crystalline lens 150 recovers original shape, and back room 110 broadens again.
Between intrinsic (proper part of posterior chamber), iris root and ciliary processes of back room 110, a shallow ridges is arranged, be called ciliary groove (ciliary sulcus).The diameter of this ditch is close with the diameter of cornea.Ciliary groove has great importance clinically in the anatomy location on sclera 190 surfaces.
In addition, also show some primary structures of eye among Figure 10, comprising: choroid 200, retina 210, Cloquct pipe 220, depending on nipple 230, optic nerve 240, cribriform plate of sclera 250, macula lutea fovea centralis 260, ora serrata 270, optical axis C, optical axis B, how much equator X1, and dissect equator X2.
The room, front and back is full of aqueous humor.Aqueous humor is produced by the ciliary processes epithelium, at first enters back room, flows into the anterior chamber through pupil, and then trabecular reticulum and the Schlemm bank of tubes through the anterior chamber goes out outside the eye to enter blood circulation.A small amount of aqueous humor can be absorbed or enter the lymph circulation around the optic nerve etc.Under normal circumstances, the generation of aqueous humor keeps dynamic equilibrium with discharge.
Aqueous humor (aqueous humor) is water white liquid, and its capacity is 0.25~0.30 milliliter, approximately 0.18 milliliter of anterior chamber, approximately 0.06 milliliter in back room.Aqueous humor is from blood plasma, and chemical composition is similar to blood plasma, and main component is water, and the content of protein obviously reduces than blood plasma, but vitamin C, Na
+, Cl
-Equal size is higher than blood plasma.The physiological function of aqueous humor is nutrition to be provided and to keep normal intraocular tension for cornea, crystalline lens and leading portion vitreous body.
Because the intraocular lens is the implantation of intraocular lens, the intraocular lens who particularly implants back room easily produces extra resistance in aqueous humor discharge system.For example, when the intraocular lens places the pupil rear, may cause the contact surface of iris and plane of crystal to increase, be adjacent to, so that aqueous humor is flowed to anterior chamber's resistance increment by back room, even cause that the aqueous humor flow direction changes into from anterior chamber to the back room.If can not effectively eliminate the resistance of aqueous humor being discharged system, then can bring adverse consequences clinically, such as intraocular pressure rising or glaucoma etc.
The object of the invention is to improve the structure of existing intraocular lens itself, more specifically, change front surface structure or the structure of intraocular lens.Be specifically related to implant the camera oculi posterior intraocular lens, the natural lens of this intraocular lens and eyes exists jointly, can be in order to the corrective ophthalmic refractive error.
See also accompanying drawing 1-3 and Fig. 7-9, embodiments of the invention are shown.The intraocular lens 10 that the present invention relates to comprises the optical body 30 that is arranged in intraocular lens 10 middle parts and is arranged in the supporter 20 that optical body 30 is used for bearing optical body 30 on every side.
No matter owing to being that anterior chamber 100 or back room 110 all are full of aqueous humour in the eyeball, after intraocular lens 10 was implanted, its rear surface was attached to the front surface of natural lens 150 basically.Because the aqueous humour of ophthalmic is to flow to anterior chamber 100 from back room 110 by pupil 180, this hydatoid flowing so that be clipped in thin water layer between intraocular lens 10 and the natural lens 150 and constantly replenished and replace renewal.
Key of the present invention is to change the structure of the front surface of intraocular lens 10, is specially the front surface structure that changes supporter 20 parts, arranges a plurality of protruding 40 at supporter 20 places near described optical body edge.These projections 40 have mound shape shape, and its bottom is arranged at the body of lens supports body 20, by the front surface protrusion of supporter 20.These projections are integrally formed with lens itself, and corresponding recess is set when making lens die, can by the acquisition lens such as injection molded with and on mound shape body structure.
After intraocular lens 10 being placed camera oculi posterior 110 location, projection 40 can contact with the rear surface of iris 140, that is, iris 140 is provided support, thereby form suitable gap to consist of additional flow of aqueous humor circulation passage around projection 40.Preferably, protruding 40 smooth surfaces are preferably smooth curved surface.More preferably, projection is from the outstanding hemispherical of described intraocular lens front surface.The design of projection 40 surface configurations, based on the consideration of iris 140 interactions.Projection 40 smooth surface can reduce the mechanical stimulus to iris as far as possible, and further, along with the amplification of pupil (pupil) with dwindle, iris 140 can " be creeped " on the surface of projection 40.Therefore, the smooth surface of projection 40 can avoid hindering or disturbing the motion of pupil.
In preferred embodiment, projection is set to hemispherical.The projection of semi-spherical shape is fit to the support that provides smooth, simultaneously, all can reduce for iris 140 interference of " creeping " from all directions.
The size setting of projection further, is described as an example of hemispherical projections example.The diameter of hemispheric projection is set to about 0.3mm to 0.5mm, highly is hemispheric radius.Certainly, according to the consideration of the flexible or concrete application of material, can suitably adjust concrete size.
The present invention is not particularly limited the quantity of projection.For example, 40,6 projections 40 of 40,4 projections of 3 projections etc. can be set.Projection 40 quantity arranges the stability that main consideration provides support, and, intraocular lens is being implanted the iris rear, projection 40 contacts the situation that the gap is provided afterwards between iris 140 and lens 10 main bodys with iris 140.
A plurality of projections are providing the mode of stable support arranged apart around optical body as intraocular lens, and intention makes these a plurality of projections jointly provide stable plane formula to support to intraocular lens, and provides the gap of expectation logical for flow of aqueous humor.
The present invention does not wish specifically to limit the material of intraocular lens, and the camera oculi posterior lens that existing multiple different materials is made all can improve according to the present invention.Be more preferably the material that has elasticity and shape-memory properties, in the serviceability temperature scope, is elastic stage in this class material, include but is not limited to soft polypropylene esters of gallic acid, silicone rubber kinds, gel-like and other macromolecule soft materials.
The example that can be used for producing the polymer of intraocular lens of the present invention also can know from following patent documentation, and described patent documentation is: August calendar year 2001 the people such as disclosed Liao on the 7th United States Patent (USP) 6,271,281; August in 2002 people such as disclosed Nanushyan on the 13rd United States Patent (USP) 6,432,137; August in 2004 people such as disclosed Liao on the 24th United States Patent (USP) 6,780,899; January in 2004 people such as disclosed Zhou on the 20th United States Patent (USP) 6,679,605; And August nineteen ninety-five the people such as disclosed Zhou on the 22nd United States Patent (USP) 5,444,106, all these patent documentations all are incorporated herein by reference.These examples all are obtained from the polymer of organic silica gel class and acrylic compounds.The example of the hydrophobic polymer that other is available comprises polyolefin, for example has SB and the styrene-isoprene copolymer of flexible elastomeric polymer networks.
Therefore the front surface structure that will be intended to improve existing intraocular lens of the present invention, can propose improved plan based on existing intraocular lens according to the present invention.
Embodiment
Below, with reference to the architecture advances of embodiment specific descriptions according to intraocular lens of the present invention.
The first embodiment
See also accompanying drawing 1-3, the embodiment that illustrates is a kind of intraocular lens that the crystal eye is arranged of implanting the camera oculi posterior position.Fig. 1 is schematic cross sectional views, illustrates according to the intraocular lens that the crystal eye is arranged of first embodiment of the invention and implants the camera oculi posterior position; Fig. 2 is the schematic plan of the present embodiment intraocular lens; Fig. 3 is the schematic cross sectional views of the present embodiment intraocular lens of getting along A-A line among Fig. 2.
As 2 and shown in Figure 3, intraocular lens 10 comprises the optical body 30 that is arranged in the middle part, and supporter 20 is used for bearing optical body 30 around being arranged in optical body 30.Optical body 30 is circular in the present embodiment, and diameter is about 5mm, and its center of circle illustrates with O.Supporter 20 overall width W are about 6mm, and total length L is about 10.8mm-11.3mm.
As shown in Fig. 2 and Fig. 3,6 projections 40 are set in the present embodiment altogether, projection 40 is hemispherical, it is solid construction, is formed in one with the intraocular lens.The front surface that projection 40 is arranged on supporter 20, be arranged in optical body 30 around, and be smoothly connected with the intraocular lens.The diameter of hemispherical projections be approximately 0.3mm to about 0.5mm.6 projections 40 are arranged apart around optical body 30, about optical body symmetry and left-right symmetric about in the of 30, so that intraocular lens 10 stable support are at the back side of iris 140.
As shown in Figure 1, the present invention is by the structure of the front surface of change intraocular lens 10, be located at the back side that projection 40 on supporter 20 front surfaces can be supported in the front surface of intraocular lens 10 iris 140, form gap 50 around the projection 40, effectively alleviate aqueous humor and flowed to anterior chamber's resistance by back room, so improved the aqueous humor circulation.
Embodiment 1 adopts flexible material, from PC-PRL (the crystal camera oculi posterior dioptric crystal is arranged) material of Hangzhou Baikang Medical Technology Co., Ltd.'s production.Proportion with this material is consistent with aqueous humor proportion, and the intraocular lens of making can be realized the centering that suspends within the eye, that is, be " 0 " weight within the eye, and " 0 " mechanical friction is kept its within the eye stable thereby can not rely on to support.
Comparative example
See also the intraocular lens comparative example shown in accompanying drawing 4, Fig. 5 and Fig. 6, illustrate a kind of intraocular lens 10 of routine '.
Be with the difference of embodiment 1, shown in Fig. 4-6, this intraocular lens 10 ' supporter 20 ' front surface around optical body 30 ' around arrange as of the present invention protruding 40.
As shown in Figure 4, these lens 10 ' be used for implanting camera oculi posterior 110, and be arranged in the front surface of natural lens 150.Because intraocular lens 10 ' the contact portion of front surface and the rear surface of iris 140 be tending towards increase, thereby intraocular lens 10 ' front surface be tending towards being adjacent to the rear surface of iris 140, therefore, aqueous humor is flowed to anterior chamber's resistance increment by back room.
The second embodiment
The second embodiment of the present invention and above-mentioned the first embodiment have similar structures, therefore, similar feature are refused repeat specification.See also accompanying drawing 7, it illustrates the schematic top plan view of the present embodiment intraocular lens.In the present embodiment, 4 hemispherical projections 40 are arranged on the front surface of supporter 20, be arranged in circular optical body 30 around, about optical body up and down symmetry and left-right symmetric, so that the intraocular lens stable support is at the iris back side.
The 3rd embodiment
The third embodiment of the present invention and above-described embodiment have similar structures, therefore, similar feature are refused repeat specification.
The present invention is applicable to the intraocular lens of the optical body structure of other kinds.What adopt in the present embodiment is oval optics body 30, is different from common circular optical body.The center of circle O of oval optics body 30 is shown in the drawings, and it is the long axis direction diameter of oval optics body and the intersection point of short-axis direction diameter.
See also accompanying drawing 8, it illustrates the schematic top plan view of third embodiment of the invention intraocular lens.In the present embodiment, 4 hemispherical projections 40 are arranged on the front surface of supporter 20, be arranged in oval optics body 30 around, about optical body up and down symmetry and left-right symmetric, so that the intraocular lens stable support is at the iris back side.
The 4th embodiment
The fourth embodiment of the present invention and above-described embodiment have similar structures, therefore, similar feature are refused repeat specification.See also accompanying drawing 9, it illustrates the schematic top plan view of fourth embodiment of the invention intraocular lens.In the present embodiment, 6 hemispherical projections 40 are arranged on the front surface of supporter 20, be arranged in oval optics body 30 around, about optical body up and down symmetry and left-right symmetric, so that the intraocular lens stable support is at the iris back side.
After understanding the present invention, those skilled in the art easily carry out multiple change to the embodiment of the invention.For example, change the structure of supporter 40 and shape and the structure of optical body.For example, at supporter 40 suitable aperture is set, aperture can be circular but be not limited to circle, and the effect of this aperture is to be convenient to doctor's operation when operation on the one hand, catch on aperture can mobile lens to correct position.On the other hand, aperture also can reduce the contact surface area of lens and natural lens.In addition, because the ophthalmic aqueous humour is constantly to flow to the anterior chamber by back room by pupil at any time, the existence of aperture also is conducive to further guarantee the patency of the front stream of aqueous humour.
What therefore, more than enumerate only is specific embodiments of the invention.Obviously, the invention is not restricted to above embodiment, many variations example can also be arranged, for other possible variation examples not in this detailed description.All distortion that those of ordinary skill in the art can directly derive or associate from content disclosed by the invention all should be thought protection scope of the present invention.The present invention is defined by the following claims.