CN102861290B - Traditional Chinese medicinal preparation having brain-invigorating and intelligent-benefiting functions - Google Patents
Traditional Chinese medicinal preparation having brain-invigorating and intelligent-benefiting functions Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal preparation having brain-invigorating and intelligent-benefiting functions. The Chinese medicinal preparation comprises the following bulk pharmaceuticals in parts by weight: 1 part of sharpleaf galangal fruit and 0.2-3 parts of turmeric. The Chinese medicinal preparation disclosed by the invention comprises Chinese medicines including sharpleaf galangal fruit, turmeric and the like. The sharpleaf galangal fruit and the turmeric can be used for prompting the medicament effect in a synergetic way, and a Chinese medicine method for regulating blood, reinforcing qi, reinforcing the kidney and increasing marrow is adopted, so that brain supply is improved, the brain function is strengthened, and reduction in the memory capability, thought capability and behavior capability caused by myelinopathy is improved remarkably. The invention provides a Chinese medicinal preparation which has a simple formula and a remarkable curative effect and is appropriate in cost for patients suffering from brain source dementia and disability.
Description
Technical field
The invention belongs to pharmaceutical technology, relate to a kind of Chinese medicine preparation with brain-tonifying effect, the improvement that this Chinese medicine preparation declines for degeneration, strain property intelligence.
Background technology
Degeneration and strain property cerebral lesion are the two large main causes that intelligence declines, along with the arrival of social senilization and the quickening of social life rhythm, the physical stress of brain increases increasingly, the risk that causes alba degeneration or the degeneration of strain property significantly rises, make in crowd brain source property in mid-aged population particularly lose intelligence, anergy patient is on the increase, and brings white elephant to society and patient family.
At present doctor trained in Western medicine is to because cerebral lesion is to the treatment of losing intelligence, anergy patient, mainly in methods such as blood fat-reducing blood pressure-decreasing, blood vessel dilating, improvement circulation, promotion metabolism and the inductions of the neurokyme factor, set about, but curative effect is totally not good enough, in treatment means, there is comparatively significantly limitation.For this reason, Chinese medicine researcher has proposed numerous Therapeutic Method according to theory of Chinese medical science, and many Chinese medicine preparation have been developed, but these preparations are mostly the large prescription compages of cocktail type multi-flavor number, in determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, targeting disappearance is comparatively obvious, the side's of entering Chinese medicine synergistic mechanism is unclear, and quality control and the increasing of cost control difficulty.Therefore, lead and look for that formula is simple, determined curative effect, the suitable Chinese prescription of cost, be the target that relevant Chinese medicine researcher is pursued always.
The research that relevant cerebral function is degenerated, researcher has proposed numerous argumentations, wherein oxidative stress is said because of continuous studied experiment and is verified and obtain most researcher approval, this argumentation has pointed out that the degradation mechanism of cerebral function and the Antioxidation Mechanism of body self have dependency closely, it has not only disclosed degeneration damage and the strain property interlinking that damage has in mechanism to degenerative of brain, more with molecules aspect can be experimental, for the observation window with excess syndrome meaning has been opened in the developmental research of related drugs.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine preparation with brain-tonifying effect.
For addressing the above problem, the technical solution used in the present invention is:
A Chinese medicine preparation with brain-tonifying effect, its crude drug is: Fructus Alpiniae Oxyphyllae 1 weight portion, Rhizoma Curcumae Longae 0.2～3 weight portion.
Preferably, in the crude drug of this Chinese medicine preparation, also added at least one in temperature compensation Chinese crude drug, Pericarpium Citri Reticulatae, Radix Glycyrrhizae.
Preferably, temperature compensation Chinese crude drug is at least one in Radix Ginseng, the Radix Astragali.
Preferably, the weight proportion of Fructus Alpiniae Oxyphyllae, Radix Ginseng is 1:0.2～3, and/or the weight proportion of Fructus Alpiniae Oxyphyllae, the Radix Astragali is: 1:2.1～4.Further be preferably, the weight proportion of Fructus Alpiniae Oxyphyllae, Radix Ginseng is 1:0.5～2, and/or the weight proportion of Fructus Alpiniae Oxyphyllae, the Radix Astragali is: 1:2.5～3.5.
Preferably, the weight proportion of Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae is 1:0.1～1, and/or the weight proportion of Fructus Alpiniae Oxyphyllae, Radix Glycyrrhizae is 1:0.1～1.Further be preferably, the weight proportion of Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae is 1:0.4～0.6, and/or the weight proportion of Fructus Alpiniae Oxyphyllae, Radix Glycyrrhizae is 1:0.4～0.6.
Preferably, the weight proportion of Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae is 1:0.5～2.
Preferably, the effective ingredient of Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae is respectively the water extract of gained medicinal residues after the alcohol steep thing of its medical material and alcohol steep.
Preferably, the water extract of gained medicinal residues after the alcohol steep thing that the effective ingredient of Pericarpium Citri Reticulatae is its medical material and alcohol steep, the water extract that the effective ingredient of Radix Glycyrrhizae is its medical material.
Preferably, the effective ingredient of Radix Ginseng is the water extract of gained medicinal residues after its alcohol steep thing and alcohol steep, the water extract that the effective ingredient of the Radix Astragali is its medical material.
Preferably, the weight portion proportioning of the crude drug of this Chinese medicine preparation is: 1 part of Fructus Alpiniae Oxyphyllae, 0.5～2 part, Rhizoma Curcumae Longae, 0.5～2 part of Radix Ginseng, 2.5～3.5 parts of the Radixs Astragali, 0.4～0.6 part of Pericarpium Citri Reticulatae, 0.4～0.6 part, Radix Glycyrrhizae.Further be preferably, the weight portion proportioning of the crude drug of this Chinese medicine preparation is: 1 part of Fructus Alpiniae Oxyphyllae, 1.5 parts, Rhizoma Curcumae Longae, 1.5 parts of Radix Ginsengs, 3 parts of the Radixs Astragali, 0.5 part of Pericarpium Citri Reticulatae, 0.5 part, Radix Glycyrrhizae.
The invention has the beneficial effects as follows:
Chinese medicine preparation of the present invention comprises the Chinese medicines such as Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae, utilize Fructus Alpiniae Oxyphyllae and the Rhizoma Curcumae Longae collaborative facilitation in drug effect, by treating blood disorders QI invigorating, reinforce the kidney and be full of the tcm methods of marrow, improving brain supports, strengthening cerebral function, declines and improves significantly the memory ability causing because of myelinopathy, ability of thinking and behavioral competence.Specifically, its endurance hypoxia-bearing capability to body has remarkable booster action, behavior cognitive competence to dysmnesia model mice is significantly improved, and dysmnesia model mouse brain antioxidant is had to obvious repair, can also obviously improve the body constitution of suffering from a deficiency of the kidney.The present invention is for brain originality is lost intelligence, anergy patient provides a kind of Chinese medicine preparation simple, curative effect is obvious, cost is suitable of filling a prescription.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is further illustrated, but do not limit to so.
In embodiment, if no special instructions, described part is weight portion.
embodiment 1
Take 1 part of raw material of Chinese medicine Fructus Alpiniae Oxyphyllae, 1 part, Rhizoma Curcumae Longae, pulverize, add 5 times of weight 75%(v/v) alcohol steep 12h, isolated by filtration medicinal residues, negative pressure reclaims ethanol, it is 1.05～1.10(70 ℃ that filtrate is concentrated into relative density) magma standby; The slag of getting it filled adds 5 times of weight decoctings to boil secondary, each 1.5h, filtration, merging filtrate and to be concentrated into relative density be 1.05～1.10(70 ℃) magma; Merge alcohol extraction, water extraction magma, and to be concentrated into relative density be 1.20～1.25(70 ℃) concentrated extract, cooling, adds starch to granulate, and cold drying (70 ℃ are following), enters dress and makes capsule.
embodiment 2
Take 1 part of raw material of Chinese medicine Fructus Alpiniae Oxyphyllae, 1.5 parts, Rhizoma Curcumae Longae, 2.5 parts of Radix Ginsengs, pulverize, add 3 times of weight 80%(v/v) alcohol steep 12h, isolated by filtration medicinal residues, negative pressure reclaims ethanol, and it is 1.05～1.10(70 ℃ that filtrate is concentrated into relative density) magma standby; The slag of getting it filled adds 4 times of weight decoctings to boil secondary, and each 1.5h filters, merging filtrate, and to be concentrated into relative density be 1.05～1.10(70 ℃) magma; Merge alcohol extraction, water extraction magma, and to be concentrated into relative density be 1.20～1.25(70 ℃) concentrated extract, cooling, adds starch, dextrin to granulate, tablet is made in cold drying (70 ℃ following), then add magnesium stearate tabletting.
embodiment 3
Take 1 part of raw material of Chinese medicine Fructus Alpiniae Oxyphyllae, 1.5 parts, Rhizoma Curcumae Longae, 2.5 parts of the Radixs Astragali, pulverize; In Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae, add 8 times of weight 85%(v/v) alcohol steep 12h, isolated by filtration medicinal residues, negative pressure reclaims ethanol, it is 1.05～1.10(70 ℃ that filtrate is concentrated into relative density) magma standby; Medicinal residues, the Radix Astragali are mixed, add 5 times of weight decoctings to boil secondary, each 1.5h, filters, merging filtrate, and to be concentrated into relative density be 1.05～1.10(70 ℃) magma; Merge alcohol extraction, water extraction magma, and to be concentrated into relative density be 1.20～1.25(70 ℃) concentrated extract, cooling, adds starch, dextrin to granulate, tablet is made in cold drying (70 ℃ following), then add magnesium stearate tabletting.
embodiment 4
Take 1 part of raw material of Chinese medicine Fructus Alpiniae Oxyphyllae, 1 part, Rhizoma Curcumae Longae, 1 part of Radix Ginseng, 3 parts of the Radixs Astragali, pulverize; In Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae, Radix Ginseng, add 6 times of weight 80%(v/v) alcohol steep 12h, isolated by filtration medicinal residues, negative pressure reclaims ethanol, it is 1.05～1.10(70 ℃ that filtrate is concentrated into relative density) magma standby; The slag of getting it filled merges the Radix Astragali, add 6 times of weight decoctings to boil secondary, each 1.5h, filtration, merging filtrate, and to be concentrated into relative density be 1.05～1.10(70 ℃) magma, merge alcohol extraction, water extraction magma, and to be concentrated into relative density be 1.20～1.25(70 ℃) concentrated extract, cooling, add starch, dextrin to granulate, cold drying (70 ℃ are following), then add magnesium stearate tabletting, make tablet.
embodiment 5
Take 3 parts of 1 part of raw material of Chinese medicine Fructus Alpiniae Oxyphyllae, 1 part, Rhizoma Curcumae Longae, 1.5 parts of Radix Ginsengs, Pericarpium Citri Reticulatae 0.5, the Radix Astragali, pulverize; In Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae, Radix Ginseng, Pericarpium Citri Reticulatae, add 7 times of weight 75%(v/v) alcohol steep 12h, isolated by filtration medicinal residues, negative pressure reclaims ethanol, it is 1.05～1.10(70 ℃ that filtrate is concentrated into relative density) magma standby; The slag of getting it filled merges the Radix Astragali, adds 4 times of weight decoctings to boil secondary, each 1.5h, filtration, merging filtrate and to be concentrated into relative density be 1.05～1.10(70 ℃) magma; Merge alcohol extraction, water extraction magma, and to be concentrated into relative density be 1.20～1.25(70 ℃) concentrated extract, cooling, adds amylodextrin and flavoring agent to granulate, cold drying (70 ℃ are following), granulation agent.
embodiment 6
Take 1 part of raw material of Chinese medicine Fructus Alpiniae Oxyphyllae, 1.5 parts, Rhizoma Curcumae Longae, 1.5 parts of Radix Ginsengs, 2.5 parts of the Radixs Astragali, 0.5 part, Radix Glycyrrhizae, pulverize; In Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae, Radix Ginseng, add 4 times of weight 95%(v/v) alcohol steep 12h, isolated by filtration medicinal residues, negative pressure reclaims ethanol, it is 1.05-1.10(70 ℃ that filtrate is concentrated into relative density) magma standby; In medicinal residues, the Radix Astragali, Radix Glycyrrhizae, add 6 times of weight decoctings to boil secondary, each 1.5h, filtration, merging filtrate and to be concentrated into relative density be 1.05～1.10(70 ℃) magma; Merge alcohol extraction, water extraction magma, and to be concentrated into relative density be 1.20～1.25(70 ℃) concentrated extract, cooling, adds amylodextrin and flavoring agent to granulate, cold drying (70 ℃ are following), granulation agent.
embodiment 7
Take 1 part of raw material of Chinese medicine Fructus Alpiniae Oxyphyllae, 1.5 parts, Rhizoma Curcumae Longae, 1.5 parts of Radix Ginsengs, Pericarpium Citri Reticulatae 0.5,3.0 parts of the Radixs Astragali, 0.5 part, Radix Glycyrrhizae, pulverize; In Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae, Radix Ginseng, Pericarpium Citri Reticulatae, add 5 times of weight 85%(v/v) alcohol steep 12h, isolated by filtration medicinal residues, negative pressure reclaims ethanol, it is 1.05～1.10(70 ℃ that filtrate is concentrated into relative density) magma standby; The slag of getting it filled merges the Radix Astragali, Radix Glycyrrhizae, add 5 times of weight decoctings to boil secondary, each 1.5h, filtration, merging filtrate and to be concentrated into relative density be 1.05～1.10(70 ℃) magma, merge alcohol extraction, water extraction magma, and to be concentrated into relative density be 1.20～1.25(70 ℃) concentrated extract, cooling, add amylodextrin and flavoring agent to granulate, cold drying (70 ℃ following), granulation agent.
embodiment 8
A Chinese medicine preparation with brain-tonifying effect, its crude drug is comprised of 0.5 part of 1 part of Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae.Its preparation method is with embodiment 1, lower same.
embodiment 9
A Chinese medicine preparation with brain-tonifying effect, its crude drug is comprised of 2 parts of 1 part of Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae.
embodiment 10
A Chinese medicine preparation with brain-tonifying effect, its crude drug is comprised of 0.2 part of 1 part of Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae.
embodiment 11
A Chinese medicine preparation with brain-tonifying effect, its crude drug is comprised of 3 parts of 1 part of Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae.
embodiment 12
A Chinese medicine preparation with brain-tonifying effect, its crude drug is comprised of 0.4 part of 1 part of Fructus Alpiniae Oxyphyllae, 2 parts, Rhizoma Curcumae Longae, 0.5 part of Radix Ginseng, 3.5 parts of the Radixs Astragali, 0.6 part of Pericarpium Citri Reticulatae, Radix Glycyrrhizae.
embodiment 13
A Chinese medicine preparation with brain-tonifying effect, its crude drug is comprised of 0.6 part of 1 part of Fructus Alpiniae Oxyphyllae, 0.5 part, Rhizoma Curcumae Longae, 2 parts of Radix Ginsengs, 2.5 parts of the Radixs Astragali, 0.4 part of Pericarpium Citri Reticulatae, Radix Glycyrrhizae.
embodiment 14
A Chinese medicine preparation with brain-tonifying effect, its crude drug is comprised of 0.6 part of 1 part of Fructus Alpiniae Oxyphyllae, 0.5 part, Rhizoma Curcumae Longae, 2 parts of Radix Ginsengs, 2.5 parts of the Radixs Astragali, 0.4 part of Pericarpium Citri Reticulatae, Radix Glycyrrhizae.
embodiment 15
A Chinese medicine preparation with brain-tonifying effect, its crude drug is comprised of 1 part of 1 part of Fructus Alpiniae Oxyphyllae, 1.5 parts, Rhizoma Curcumae Longae, 3 parts of Radix Ginsengs, 2.1 parts of the Radixs Astragali, 0.1 part of Pericarpium Citri Reticulatae, Radix Glycyrrhizae.
embodiment 16
A Chinese medicine preparation with brain-tonifying effect, its crude drug is comprised of 0.1 part of 1 part of Fructus Alpiniae Oxyphyllae, 3 parts, Rhizoma Curcumae Longae, 0.2 part of Radix Ginseng, 4 parts of the Radixs Astragali, 1 part of Pericarpium Citri Reticulatae, Radix Glycyrrhizae.
Chinese medicine preparation of the present invention has been followed traditional tcm theory in prescription compatibility and processing technology, and by modern pharmacodynamics method, its safety and effectiveness is made to checking.
the acute toxicity test of Chinese medicine preparation of the present invention is observed:
By adding water by the concentrated extract (4.0g crude drug/1g extractum) of embodiment 7 preparations, be made into 0.7g/ml suspension, press 80ml/kg gastric infusion to the kunming mice (body weight 22 ± 2g) of hungry 16h, in 20 minutes, gradation completes, after administration, in 30 minutes, observe the movable minimizing of mice, movable recovery normally after 1h, administration in continuous 7 days occurs without death, because being limited to administration volume and liquor strength, test fails to measure the LD50 value of said preparation, but experiment shows that the maximum tolerated dose of said preparation is greater than 56g extractum/kg(and is equivalent to 224g crude drug/kg), for 800 times of Clinical design dosage (maximum tolerated doses * per capita body weight ÷ Clinical design dosage).Result shows, the safety of said preparation clinical practice tool.
The long term toxicity test of Chinese medicine preparation of the present invention is observed:
Concentrated extract 2.8g(by maximum dosis tolerata 1/20 is equivalent to 11.2g crude drug/kg), it to body weight, is SD rat gastric infusion every day 1 time of 180 ± 20g, male and female half and half, successive administration 90 days, observe administration on rat diet, excretion, body weight change and active situation without impact, routine blood test, liver function test are without extremely, viscera organ pathology cuts into slices without abnormal, and result shows, the safety of said preparation long-term taking tool.
the endurance hypoxia endurance test of Chinese medicine preparation of the present invention is observed:
Animal: 70 of kunming mices, male and female half and half, body weight 22 ± 2g, following test mice requires all identical.
Tested mice is divided into blank group, Chinese medicine preparation high dose group of the present invention, Chinese medicine preparation low dose group of the present invention, model control group, except blank group, all the other each groups are established as Mouse Kidney virtual model for 28 days by the administration of 0.2mg/10gd dexamethasone subcutaneous injection, dexamethasone was administered to after the 14th day, from the 15th day, use embodiment 1 simultaneously, the concentrated extract of embodiment 7 preparations is respectively to administration group gastric infusion, the high dose group of dosage: embodiment 1 group is pressed 60mg/kgd, low dose group is pressed the dosage of 40mg/kgd, the high dose group of embodiment 7 groups is pressed 80mg/kgd, low dose group is pressed the dosage of 50mg/kgd, gastric infusion is 14 days continuously, within after last administration 1 hour, start test.
1. time test is adhered in swimming:
It is that 12cm, water temperature are the glass cistern of 25 ℃ that tested mice is put into the depth of water, with respiratory arrest, is as the criterion, and records the death time of mice, the results are shown in Table 1.
2. closed chamber is adhered to time test:
Tested mice is put into the airtight wide mouthed bottle of little volume that fills 15g sodica calx, with respiratory arrest, be as the criterion, record the death time of mice, the results are shown in Table 2.
From table 1 and table 2, taking the mice endurance of Chinese medicine preparation of the present invention, the time of anoxia enduring obviously increases, and is positive-effect with dosage, and this Chinese medicine preparation improves significantly to the physical condition of the mice of suffering from a deficiency of the kidney as seen.And the formula of selecting temperature compensation Chinese crude drug compatibility (embodiment 7) in herbal pharmaceutical agent of the present invention to tested mice fatigue resistance to improve effect more obvious.
chinese medicine preparation of the present invention is to improving amnemonic experimental observation:
Animal: 96 of kunming mices, male and female half and half, body weight 22 ± 2g.Following test mice requires all identical.
Tested mice is divided into blank group, Chinese medicine preparation high dose group of the present invention, Chinese medicine preparation low dose group of the present invention, model control group, except blank group, model control group not, the concentrated extract of all the other two embodiment 1 for administration group, embodiment 7 preparations is gastric infusion respectively, the high dose group of dosage: embodiment 1 group is pressed 60mg/kg. d, low dose group by the dosage of 40mg/kg. d, the high dose group of embodiment 7 groups is pressed 80mg/kg. d, low dose group by the dosage of 50mg/kg. d, and gastric infusion is 14 days continuously.After last administration, after 1 hour, test.
1. the observation on the impact of mouse memory acquired disturbance model:
After last administration after 1 hour, by model control group and the tested mice of two administration groups are established as to mouse memory acquired disturbance model group by the dosage lumbar injection scopolamine 5mg/kg of 10ml/KG, after administration 30min, together with blank, organize tested mice, put on the electricity irritation test reflective box valve rubber of 12 * 12 * 18cm, connect 50v alternating current, carry out electricity irritation reflection step down test training 5min, after 24 hours, test mice first and jump off the incubation period of valve rubber and the errors number in 5min.Test data carries out statistical disposition with statistical package PEMS data base.The results are shown in Table 3.
As shown in Table 3, Chinese medicine preparation of the present invention has obvious repair to tested mouse memory acquired disturbance, and is positive-effect with dosage.
2. mouse memory being reproduced to Disorder Model impact observes:
After last administration after 1 hour, as front method is carried out step down test training 5min to tested mice, after 24 hours, as front method, carrying out electricity irritation test reflective box tests, 30min before test, by giving 30% medical ethanol to model control group and two administration group mices by the dosage gavage of 10ml/KG, be established as mouse memory and reproduce Disorder Model group, after together with blank, organize tested mice, put into electricity irritation test reflective box and test, test mice first jumps off the incubation period of valve rubber and the errors number in 5min.The same method of test data statistical processing methods.The results are shown in Table 4,
As shown in Table 4, Chinese medicine preparation of the present invention reproduces obstacle to tested mouse memory obvious repair, and is positive-effect with dosage.
chinese medicine preparation of the present invention and single raw material pharmacodynamics contrast test are observed:
Animal: 40 of kunming mices, male and female half and half, body weight 22 ± 2g, following test mice requires all identical.
Medicine: preparation method is all prepared the method for concentrated extract by embodiment 1, embodiment 1 concentrated extract is made by 1 part of Fructus Alpiniae Oxyphyllae, 1 portion of Rhizoma Curcumae Longae; Fructus Alpiniae Oxyphyllae concentrated extract is made by 2 parts of Fructus Alpiniae Oxyphyllae; 2 portions of Rhizoma Curcumae Longaes of Rhizoma Curcumae Longae concentrated extract make.Concentrated extract active ingredient is the suitable 4.0g crude drug of 1g extractum.
Tested mice is divided into blank group, 1 group of embodiment, Fructus Alpiniae Oxyphyllae group, Rhizoma Curcumae Longae group, model control group, except blank group, all the other each groups are established as degeneration dysmnesia model for 42 days by the administration of D-galactose 50mg/Kgd subcutaneous injection, wherein 1 group of embodiment, Fructus Alpiniae Oxyphyllae group, Rhizoma Curcumae Longae group were from D-galactose administration the 1st day, with each, organize corresponding concentrated extract gastric infusion simultaneously, dosage is all by 60mg/kgd, be administered to the 42nd day, within after last administration 1 hour, start behavior test.
1. on mice degeneration dysmnesia model, impact is observed:
Together with blank, organize tested mice and put into electricity irritation test reflective box and test, process is the same.The results are shown in Table 5.
As shown in Table 5, the present invention adds after Fructus Alpiniae Oxyphyllae and Rhizoma Curcumae Longae combination simultaneously, the improvement effect of the behavior cognitive competence of degeneration dysmnesia model mice is greater than to the effect of independent interpolation Fructus Alpiniae Oxyphyllae or Rhizoma Curcumae Longae, visible, in Chinese medicine preparation of the present invention, Fructus Alpiniae Oxyphyllae and Rhizoma Curcumae Longae have collaborative facilitation, can significantly improve the amnemonic repair of mice degeneration.
2. pair mice degeneration dysmnesia model brain biochemical is observed:
After above-mentioned behavior off-test, the tested mice of sacrificed by decapitation immediately, sharp separation bilateral hippocampus under low temperature, accurately weigh, and add by weight normal saline to make 10% brain tissue homogenate, after centrifugal, get supernatant and carry out biochemical test, test mouse brain SOD vigor and MDA content, method of testing is undertaken by SOD, MDA test kit description, and test data carries out statistical disposition with statistical package PEMS data base.The results are shown in Table 6.
From table 6 also, the present invention adds after Fructus Alpiniae Oxyphyllae and Rhizoma Curcumae Longae combination simultaneously, the effect of the reduction of the raising of degeneration dysmnesia model mouse brain SOD vigor and MDA content is greater than to the effect of independent interpolation Fructus Alpiniae Oxyphyllae or Rhizoma Curcumae Longae, and add the level (blank group) that Fructus Alpiniae Oxyphyllae and the rear effect of Rhizoma Curcumae Longae combination almost approach normal mouse simultaneously, visible, in Chinese medicine preparation of the present invention, Fructus Alpiniae Oxyphyllae and Rhizoma Curcumae Longae have collaborative facilitation, can significantly promote the raising of degeneration dysmnesia model mouse brain SOD vigor and the reduction of MDA content.
Above-mentioned results of pharmacodynamic test demonstration, Chinese medicine preparation of the present invention improves significantly to the physical condition of the mice of suffering from a deficiency of the kidney; Tested mice endurance, hypoxia-bearing capability all there are is obvious booster action and be positive-effect with dosage; Tested mouse memory acquired disturbance and memory represents obstacle are all had to obvious repair, and be positive-effect with dosage.Result also shows, the compatibility raw material of the Chinese medicine preparation of the present invention being comprised of Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae has drug effect to work in coordination with facilitation, the behavior cognitive competence of degeneration dysmnesia model mice and brain antioxidant are all improved significantly, result of the test comprehensively shows, Chinese medicine preparation of the present invention has strengthening cerebral function, improves the effect of memory ability, ability of thinking and behavioral competence.
Claims (10)
1. a Chinese medicine preparation with brain-tonifying effect, its crude drug is: Fructus Alpiniae Oxyphyllae 1 weight portion, Rhizoma Curcumae Longae 0.2～3 weight portion.
2. Chinese medicine preparation according to claim 1, is characterized in that: in crude drug, also added at least one in temperature compensation Chinese crude drug, Pericarpium Citri Reticulatae, Radix Glycyrrhizae.
3. Chinese medicine preparation according to claim 2, is characterized in that: temperature compensation Chinese crude drug is at least one in Radix Ginseng, the Radix Astragali.
4. Chinese medicine preparation according to claim 3, is characterized in that: the weight proportion of Fructus Alpiniae Oxyphyllae, Radix Ginseng is 1:0.2～3, and/or the weight proportion of Fructus Alpiniae Oxyphyllae, the Radix Astragali is: 1:2.1～4.
5. Chinese medicine preparation according to claim 2, is characterized in that: the weight proportion of Fructus Alpiniae Oxyphyllae, Pericarpium Citri Reticulatae is 1:0.1～1, and/or the weight proportion of Fructus Alpiniae Oxyphyllae, Radix Glycyrrhizae is 1:0.1～1.
6. according to the Chinese medicine preparation described in claim 1～5 any one, it is characterized in that: the weight proportion of Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae is 1:0.5～2.
7. according to the Chinese medicine preparation described in claim 1～5 any one, it is characterized in that: the effective ingredient of Fructus Alpiniae Oxyphyllae, Rhizoma Curcumae Longae is respectively the water extract of gained medicinal residues after the alcohol steep thing of its medical material and alcohol steep.
8. according to the Chinese medicine preparation described in claim 2～5 any one, it is characterized in that: the water extract of gained medicinal residues after the alcohol steep thing that the effective ingredient of Pericarpium Citri Reticulatae is its medical material and alcohol steep, the water extract that the effective ingredient of Radix Glycyrrhizae is its medical material.
9. according to the Chinese medicine preparation described in claim 3 or 4, it is characterized in that: the effective ingredient of Radix Ginseng is the water extract of gained medicinal residues after its alcohol steep thing and alcohol steep, the water extract that the effective ingredient of the Radix Astragali is its medical material.
10. Chinese medicine preparation according to claim 6, is characterized in that: the weight portion proportioning of the crude drug of this Chinese medicine preparation is: 1 part of Fructus Alpiniae Oxyphyllae, 0.5～2 part, Rhizoma Curcumae Longae, 0.5～2 part of Radix Ginseng, 2.5～3.5 parts of the Radixs Astragali, 0.4～0.6 part of Pericarpium Citri Reticulatae, 0.4～0.6 part, Radix Glycyrrhizae.
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| CN201210331789.XA CN102861290B (en) | 2012-09-10 | 2012-09-10 | Traditional Chinese medicinal preparation having brain-invigorating and intelligent-benefiting functions |
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| CN104041813A (en) * | 2014-06-17 | 2014-09-17 | 史克勇 | Formula of health food capable of improving memory |
| CN106039172B (en) * | 2016-07-06 | 2019-10-01 | 南方医科大学 | There is the Chinese medicine composition for improving memory function and its application containing centella |
| CN110694035A (en) * | 2019-11-23 | 2020-01-17 | 卢逊 | Oral Chinese medicinal composition and its preparation method |
| CN112402554B (en) * | 2020-10-26 | 2022-03-01 | 中国中医科学院广安门医院 | Traditional Chinese medicine composition for treating leukoencephalopathy and application thereof |
| CN114098085B (en) * | 2021-12-06 | 2023-05-12 | 中国医科大学 | Functional food composition with auxiliary memory improving function and application thereof |
| CN115886258A (en) * | 2022-12-30 | 2023-04-04 | 上海交大昂立股份有限公司 | Composite probiotic composition for improving physiological memory attenuation |
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