CN102854142A - Optical resolution type photoacoustic microscope based on optical beam scanning - Google Patents
Optical resolution type photoacoustic microscope based on optical beam scanning Download PDFInfo
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- CN102854142A CN102854142A CN2012103086931A CN201210308693A CN102854142A CN 102854142 A CN102854142 A CN 102854142A CN 2012103086931 A CN2012103086931 A CN 2012103086931A CN 201210308693 A CN201210308693 A CN 201210308693A CN 102854142 A CN102854142 A CN 102854142A
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Abstract
The invention provides an optical resolution type photoacoustic microscope based on optical beam scanning. The photoacoustic microscope comprises a laser diode, a collimating lens, a multidimensional laser galvanometer, a focusing lens, a rectangular prism, a coupling liquid box, an ultrasonic coupling liquid, a film, a shell, a lifting platform, an ultrasonic sensor, a signal processing circuit, a data acquisition circuit, a computer, a galvanometer driving circuit, a clock circuit and a driving power circuit. According to the invention, miniature, inexpensive and easily maintained laser diode is applied to the field of optical resolution forward photoacoustic microscopy excitation, and the laser galvanometer is used to realize substitution of mechanical scanning by beam scanning to achieve fast imaging. The photoacoustic microscope has the advantages of portable volume, high resolution and fast imaging, and can be widely applied to photoacoustic microimaging in the fields of material detection, industrial inspection and medical image.
Description
Technical field
The present invention relates to a kind of opto-acoustic microscopic imaging technology, particularly relate to a kind of optical resolution formula photoacoustic microscope based on beam flying.
Background technology
Photoacoustic imaging is to utilize short-pulse laser as excitaton source, survey different tissues to the inhomogeneous different ultrasonic signal that produces of light absorption by using ultrasonic transducer, have resolution height, contrast height, not damaged, without characteristics such as ionisation effects, also have the darker and high-resolution advantage of ultrasonic imaging investigation depth.
Wherein, optical resolution formula opto-acoustic microscopic imaging is the image technology that a kind of newly-developed gets up, can realize that the hundreds of micron is to the high resolving power detection image of tens Nano grades, and have the advantages such as high optical contrast, "dead" damage, use safe and convenient, its lateral resolution depends mainly on the focusing focal spot size of incident laser, and it is irrelevant with the reception dominant frequency of sensor, the less then resolution of focus diameter is higher, can learn diffraction limit (or restriction point) close to dipped beam in theory, and its imaging depth is determined by the optical scattering coefficient of sample mainly.And the acoustics that is developed is at first differentiated the dominant frequency that the lateral resolution of formula opto-acoustic microscopic imaging depends mainly on focused ultrasonic sensor, and the higher then resolution of frequency is higher, generally between the hundreds of micron is to several microns.But because the ultrasonic attenuation of ultrahigh frequency composition is faster, so its imaging depth is by serious restriction.
Hajireza in 2011 etc. have reported and have adopted the dorsad optical resolution formula photoacoustic microscope of receiving mode (P. Hajireza of two-dimensional laser vibration mirror scanning, W. Shi, and R. J. Zemp, " Label-free in vivo fiber-based optical-resolution photoacoustic microscopy; " Opt. Lett. 36 (20), 4107-4109,2011); Yuan in 2012 etc. have reported optical resolution formula forward light sonomicroscope (the Y. Yuan that adopts the two-dimensional laser vibration mirror scanning, Si Yang and D. Xing, " Optical-resolution photoacoustic microscopy based on two-dimensional scanning galvanometer; " Appl. Phys. Lett. 100,023702,2012).More than report has all adopted the laser galvanometer to realize that beam flying replaces the mode of mechanical scanning to reach fast imaging, but all adopt the solid state laser of relatively high power as the photo-acoustic excitation source, and such laser instrument has usually numerous shortcomings such as volume is large, price is high, Maintenance Difficulty, and obviously there are sizable limitation in actual applications in the miniaturization and the portable design that are difficult to the system that realizes.
Summary of the invention
For the problems referred to above, the technical problem to be solved in the present invention provides a kind of portable light sonomicroscope based on beam flying, it combines multi-dimension laser galvanometer small-sized, quick, easy care with laser diode, can realize portable quick optoacoustic micro imaging system.
For achieving the above object, the present invention adopts following technical scheme:
A kind of optical resolution formula photoacoustic microscope based on beam flying, it comprises laser diode, collimation lens, multi-dimension laser galvanometer, condenser lens, right-angle prism, coupling liquid box, ultrasonic coupling liquid, film, shell, lifting table, sonac, signal pre-processing circuit, data acquisition circuit, computing machine, galvanometer driving circuit, clock circuit, driving power circuit; Described laser diode is launched pulsed or the continous way laser after modulation, through behind collimation lens and the multi-dimension laser galvanometer again by the condenser lens of high-NA be focused into diameter tens microns to the focus tens nanometers, then pass and focus on focus behind right-angle prism, coupling liquid box, the film and be radiated at and inspire photoacoustic signal on the sample; Described galvanometer driving circuit drives the deflection of multi-dimension laser galvanometer makes laser spot do laser scanning at sample, has namely obtained multidimensional optoacoustic field; After photoacoustic signal passes film, by ultrasonic coupling liquid coupling and reflex to sonac by the hypotenuse of right-angle prism and be received, then successively through being imported into computing machine behind signal pre-processing circuit, the data acquisition circuit, can realize the opto-acoustic microscopic imaging of multidimensional by image reconstruction, the lateral resolution of its micro-imaging only is decided by the focus diameter of Laser Focusing again.
Described laser diode, driving power circuit, clock circuit successively wire connect; Described clock circuit is connected with the computing machine wire; Described sonac, signal pre-processing circuit, data acquisition circuit, computing machine successively wire connect; Described multi-dimension laser galvanometer, galvanometer driving circuit, computing machine successively wire connect; The hypotenuse of described right-angle prism has the coupling liquid of ultrasonic coupling liquid box to be close to inner being full of; Described coupling liquid box and sonac are close to; Described coupling liquid box overlaps with the lower ending opening of shell, and sealed together by film; Described film is close to sample contained on the lifting table; Described laser diode, collimation lens, multi-dimension laser galvanometer, condenser lens, right-angle prism, coupling liquid box, sonac are placed in the shell.
According to the Abbe diffraction theory, the theoretical lateral resolution R of described photoacoustic microscope is 0.51 λ/NA, i.e. the large full duration diameter of the half-shadow of Laser Focusing focus, and wherein λ is the wavelength of laser, NA is the numerical aperture of condenser lens.
Described sonac is unit probe or polynary linear array, arc battle array, ring battle array or face battle array probe.
The radiation wavelength of described laser diode one or more wavelength that are ultraviolet to the infra-red range.
The laser galvanometer system that described multi-dimension laser galvanometer is two dimension or 3-D scanning.
Described collimation lens and condenser lens can be formed by one or more lens combination respectively.
Described coupling liquid box is made by light transmissive material.
The invention has the beneficial effects as follows:
(1) the present invention adopts laser diode as the photo-acoustic excitation source, has the advantages such as volume is little, price is low, easy care, high stability, the portable construction design of feasible system.
(2) focus on by the laser beam that laser diode is produced, realized optical resolution formula opto-acoustic microscopic imaging, differentiate the formula opto-acoustic microscopic imaging with respect to acoustics and have the advantages such as resolution height, imaging depth is large, the signal post-processing circuit is simple.
(3) owing to adopt two dimension or three-dimensional laser galvanometer, it is that 300 * 300 analyzing spots only need 30 seconds that common sweep velocity is not less than 3KHz(), sweep velocity is done circumference and linear mechanical scanning far above traditional sensor by step motor control, effectively raises scanning accuracy, real-time and the practicality of system.
(4) because laser diode and sonac are mode configuration dorsad, exciting with sensing of optoacoustic realized integrated design, Effective Raise system compact, stability and practicality, can be widely used in the fields such as material tests, industrial flaw detection, medical image.
Description of drawings
Fig. 1 is the structural representation of embodiment 1.
Embodiment
Below in conjunction with accompanying drawing embodiments of the invention are specified:
The structure of embodiment 1 present embodiment as shown in Figure 1, the name of each element is called: 1. laser diode, 2. collimation lens, 3. multi-dimension laser galvanometer, 4. condenser lens, 5. right-angle prism, 6. coupling liquid box, 7. ultrasonic coupling liquid, 8. film, 9. shell, 10. lifting table, 11. sonacs, 12. signal pre-processing circuits, 13. data acquisition circuits, 14. computing machines, 15. galvanometer driving circuits, 16. clock circuits, 17. driving power circuits.
Wherein laser diode 1 is selected the semiconductor laser diode (PFAS1S12, PerkinElmer) of pulse, and operation wavelength is 850nm, and single pulse energy is about 3.9uJ; Sonac 11 is 256 array element face array probes (5M16*16-1.0*1.0, Guangzhou Doppler Electronics Technology Co., Ltd.) of hollow structure, and its centre frequency is 5.0MHz, and the effective aperture is 16mm, and the shell model is B16; Condenser lens 4 adopts numerical apertures up to 0.62 non-spherical lens, and its effective focusing length EFL is 6.75mm, and operating distance D is 4.27mm.
This example comprises laser diode, collimation lens, multi-dimension laser galvanometer, condenser lens, right-angle prism, coupling liquid box, ultrasonic coupling liquid, film, shell, lifting table, sonac, signal pre-processing circuit, data acquisition circuit, computing machine, galvanometer driving circuit, clock circuit, driving power circuit; Described laser diode is launched pulsed or the continous way laser after modulation, through behind collimation lens and the multi-dimension laser galvanometer again by the condenser lens of high-NA be focused into diameter tens microns to the focus tens nanometers, then pass and focus on focus behind right-angle prism, coupling liquid box, the film and be radiated at and inspire photoacoustic signal on the sample; Described galvanometer driving circuit drives the deflection of multi-dimension laser galvanometer makes laser spot do laser scanning at sample, has namely obtained multidimensional optoacoustic field; After photoacoustic signal passes film, by ultrasonic coupling liquid coupling and reflex to sonac by the hypotenuse of right-angle prism and be received, then successively through being imported into computing machine behind signal pre-processing circuit, the data acquisition circuit, can realize the opto-acoustic microscopic imaging of multidimensional by image reconstruction, the lateral resolution of its micro-imaging only is decided by the focus diameter of Laser Focusing again.
Described laser diode, driving power circuit, clock circuit successively wire connect; Described clock circuit is connected with the computing machine wire; Described sonac, signal pre-processing circuit, data acquisition circuit, computing machine successively wire connect; Described multi-dimension laser galvanometer, galvanometer driving circuit, computing machine successively wire connect; The hypotenuse of described right-angle prism has the coupling liquid of ultrasonic coupling liquid box to be close to inner being full of; Described coupling liquid box and sonac are close to; Described coupling liquid box overlaps with the lower ending opening of shell, and sealed together by film; Described film is close to sample contained on the lifting table; Described laser diode, collimation lens, multi-dimension laser galvanometer, condenser lens, right-angle prism, coupling liquid box, sonac are placed in the shell.
According to the Abbe diffraction theory, the theoretical lateral resolution R of described photoacoustic microscope is 0.51 λ/NA, i.e. the large full duration diameter of the half-shadow of Laser Focusing focus, and wherein λ is the wavelength of laser, NA is the numerical aperture of condenser lens.
Described sonac is unit probe or polynary linear array, arc battle array, ring battle array or face battle array probe.
The radiation wavelength of described laser diode one or more wavelength that are ultraviolet to the infra-red range.
The laser galvanometer system that described multi-dimension laser galvanometer is two dimension or 3-D scanning.
Described collimation lens and condenser lens can be formed by one or more lens combination respectively.
Described coupling liquid box is made by light transmissive material.
The present embodiment concrete operation step is:
1) after the pulse laser of semiconductor laser diode emission is collimated by collimation lens, focus on again the focus of hundreds of nanometer diameter through multi-dimension laser galvanometer and condenser lens, pass to be radiated at behind right-angle prism, coupling liquid box, the film and be inspired photoacoustic signal on the sample;
2) after photoacoustic signal passes film, by ultrasonic coupling liquid coupling and reflex to sonac by the hypotenuse of right-angle prism and be received, behind signal pre-processing circuit, be transported to computing machine by data acquisition circuit and do subsequent treatment;
3) computing machine makes laser spot do laser scanning at sample by the deflection of galvanometer driving circuit driving multi-dimension laser galvanometer, has namely obtained multidimensional optoacoustic field, and repeating step 2 receives the photoacoustic signal of each scanning simultaneously;
4) photoacoustic signal that collects by the image reconstruction routine processes can be realized the opto-acoustic microscopic imaging of multidimensional.Because the unit of shaking of ultrasound array sensor can receive altogether 256 photoacoustic signals in each scanning, rebuild multidimensional photoacoustic image (such as the photoacoustic signal of conditions such as can selecting that amplitude is maximum, the transit time is the shortest or ringing effect is minimum) so can preferably satisfy the photoacoustic signal of certain condition, to realize best image quality.
2 one kinds of optical resolution formula photoacoustic microscopes based on beam flying of embodiment, with embodiment 1 structural similarity, difference is: and the unit angle probe of the hollow structure that sonac 11 employing Guangzhou Doppler Electronics Technology Co., Ltd. produce (5.0P9 * 9K1), its centre frequency is 5.0MHz, be of a size of 9 mm * 9 mm, external tapping adopts Q9(BNC) interface.
Claims (6)
1. the optical resolution formula photoacoustic microscope based on beam flying is characterized in that comprising laser diode (1), collimation lens (2), multi-dimension laser galvanometer (3), condenser lens (4), right-angle prism (5), coupling liquid box (6), ultrasonic coupling liquid (7), film (8), shell (9), lifting table (10), sonac (11), signal pre-processing circuit (12), data acquisition circuit (13), computing machine (14), galvanometer driving circuit (15), clock circuit (16), driving power circuit (17); Described laser diode (1), driving power circuit (17), clock circuit (16) successively wire connect; Described clock circuit (16) is connected with computing machine (14) wire; Described sonac (11), signal pre-processing circuit (12), data acquisition circuit (13), computing machine (14) successively wire connect; Described multi-dimension laser galvanometer (3), galvanometer driving circuit (15), computing machine (14) successively wire connect; The hypotenuse of described right-angle prism (5) and inside are full of has the coupling liquid box of ultrasonic coupling liquid (7) (6) to be close to; Described coupling liquid box (6) is close to sonac (11); Described coupling liquid box (6) overlaps with the lower ending opening of shell (9), and sealed together by film (8); Described film (8) is close to the upper contained sample of lifting table (10); Described laser diode (1), collimation lens (2), multi-dimension laser galvanometer (3), condenser lens (4), right-angle prism (5), coupling liquid box (6), sonac (11) are placed in the shell (9); Described laser diode (1) is launched pulsed or the continous way laser after modulation, behind collimation lens (2) and multi-dimension laser galvanometer (3) again by the condenser lens (4) of high-NA be focused into diameter tens microns to the focus tens nanometers, then pass and focus on focus behind right-angle prism (5), coupling liquid box (6), the film (8) and be radiated at and inspire photoacoustic signal on the sample; Described galvanometer driving circuit (15) drives multi-dimension laser galvanometer (3) deflection makes laser spot do laser scanning at sample, has namely obtained multidimensional optoacoustic field; After photoacoustic signal passes film (8), by ultrasonic coupling liquid (7) coupling and reflex to sonac (11) by the hypotenuse of right-angle prism (5) and be received, then be imported into computing machine (14) after passing through successively signal pre-processing circuit (12), data acquisition circuit (13), can realize the opto-acoustic microscopic imaging of multidimensional by image reconstruction, the lateral resolution of its micro-imaging only is decided by the focus diameter of Laser Focusing again.
2. the optical resolution formula photoacoustic microscope based on beam flying according to claim 1, it is characterized in that: according to the Abbe diffraction theory, the theoretical lateral resolution R of described photoacoustic microscope is 0.51 λ/NA, it is the large full duration diameter of half-shadow of Laser Focusing focus, wherein λ is the wavelength of laser, and NA is the numerical aperture of condenser lens (4).
3. the optical resolution formula photoacoustic microscope based on beam flying according to claim 1 is characterized in that: described sonac (11) is unit probe or polynary linear array, arc battle array, ring battle array or face battle array probe.
4. the optical resolution formula photoacoustic microscope based on beam flying according to claim 1 is characterized in that: the radiation wavelength of described laser diode (1) one or more wavelength that are ultraviolet to the infra-red range
Optical resolution formula photoacoustic microscope based on beam flying according to claim 1 is characterized in that: described multi-dimension laser galvanometer (3) is the laser galvanometer system of two dimension or 3-D scanning.
5. the optical resolution formula photoacoustic microscope based on beam flying according to claim 1, it is characterized in that: described collimation lens (2) and condenser lens (4) can be formed by one or more lens combination respectively.
6. the optical resolution formula photoacoustic microscope based on beam flying according to claim 1, it is characterized in that: described coupling liquid box (6) is made by light transmissive material.
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| CN103054558A (en) * | 2013-01-29 | 2013-04-24 | 广州佰奥廷电子科技有限公司 | Integrated handheld opto-acoustic microscope imaging probe |
| CN103149152A (en) * | 2013-01-29 | 2013-06-12 | 广州佰奥廷电子科技有限公司 | Varifocal scanning optoacoustic microimaging device and method thereof |
| CN104614349A (en) * | 2015-03-03 | 2015-05-13 | 北京理工大学 | Reflection type spectral pupil confocal-photoacoustic microimaging device and method |
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| CN103054558A (en) * | 2013-01-29 | 2013-04-24 | 广州佰奥廷电子科技有限公司 | Integrated handheld opto-acoustic microscope imaging probe |
| CN103149152A (en) * | 2013-01-29 | 2013-06-12 | 广州佰奥廷电子科技有限公司 | Varifocal scanning optoacoustic microimaging device and method thereof |
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| CN104614349A (en) * | 2015-03-03 | 2015-05-13 | 北京理工大学 | Reflection type spectral pupil confocal-photoacoustic microimaging device and method |
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| CN107837069A (en) * | 2016-09-18 | 2018-03-27 | 哈尔滨工业大学（威海） | A kind of opto-acoustic microscopic imaging system and method |
| CN107049242A (en) * | 2017-01-24 | 2017-08-18 | 青岛大学 | Scan-type human microvascular ultra microstructure 3-D imaging system |
| CN107049242B (en) * | 2017-01-24 | 2023-08-29 | 青岛大学 | Scanning type human body microvascular ultrastructural three-dimensional imaging system |
| CN107831589A (en) * | 2017-12-04 | 2018-03-23 | 中国计量大学 | A kind of controllable super-resolution microscope equipment of focusing based on spherical micro-nano liquid lens |
| CN107831589B (en) * | 2017-12-04 | 2024-02-02 | 中国计量大学 | Focusing controllable super-resolution microscopic device based on spherical micro-nano liquid drop lens |
| CN109864716A (en) * | 2019-05-06 | 2019-06-11 | 南昌洋深电子科技有限公司 | A kind of miniature opto-acoustic microscopic imaging system and method for low-frequency range |
| CN110537898A (en) * | 2019-09-06 | 2019-12-06 | 上海交通大学 | Manufacturing method of focus-adjustable photoacoustic endoscopic microscope |
| CN110558943A (en) * | 2019-09-06 | 2019-12-13 | 中国科学院深圳先进技术研究院 | optical imaging method, related device and system |
| CN110558943B (en) * | 2019-09-06 | 2022-03-04 | 中国科学院深圳先进技术研究院 | Optical imaging method, related device and system |
| ES2916219A1 (en) * | 2022-04-01 | 2022-06-29 | Univ Valencia Politecnica | Optical device, system and procedure of obtaining photoacoustic images through the use of homogenized beams from pressed luminous sources (Machine-translation by Google Translate, not legally binding) |
| WO2023187238A1 (en) * | 2022-04-01 | 2023-10-05 | Universitat Politècnica De València | Optical device, system and method for producing photoacoustic images using homogenised beams from pulsed light sources |
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