CN102755640A - Plant chinese herbal medicine essence complex disinfectant - Google Patents

Abstract

The invention relates to a plant Chinese herbal medicine essence complex disinfectant which is widely used in washing and disinfecting in daily lives, and is suitable for various fields in people's daily lives. The product provided by the invention is extracted from pure Chinese herbal medicine essences, and is strictly screened and formulated. According to the invention, golden thread and largehead atractylodes rhizome are adopted as main medicines, and Chinese herbal medicines such as amur corktree bark, officinal magnolia bark, Baikal skullcap root, and honeysuckle flower are adopted as auxiliary medicines. The main medicines and the auxiliary medicines provide a synergetic effect and an adducting effect. The complex disinfectant is advantaged in high-efficiency bactericidal effect, no side effect, no damage to human skins, no volatile irritating odor, no corrosion to disinfected object, and long-lasting effect. The invention leads a novel direction of the disinfection field.

Description

The composite disinfectant solution of vegetable Chinese herbal medicine essence

Technical field the present invention relates to the composite disinfectant solution of a kind of vegetable Chinese herbal medicine essence, it is characterized in that the Chinese herbal medicine composition of selected reasonable compatibility.The active ingredient of prescription is a Rhizoma Coptidis, the Rhizoma Atractylodis Macrocephalae, and Cortex Phellodendri, Cortex Magnoliae Officinalis, Radix Scutellariae, Flos Lonicerae, Fructus Gardeniae, Spica Prunellae forms through the special process configuration.The growth in the living standard of Along with people's; Disinfectant is undertaken the heavy burden of sanitation and hygiene in the daily life gradually; After particularly having experienced large-scale epidemic situation as the SARS; People's the health consciousness and the consumption of hygienic article begin to improve gradually, and its sterile products is also answered wine and given birth to, like early stage chemosterilant 84 chlorine-containing disinfectants, trichlorine effervescent, bromine chlorine chlordantoin etc.; The kind of exploitation also has the disinfectant of chloride type, aldehydes, biological enzyme, iodine class disinfectant, quaternary ammonium salt immediately; Its invention and application make the sterilization field constantly enlarge, and as disinfectant solution, the natural product washing disinfecting product of skin and hands, all kinds of detergent with sterilizing becomes an indispensable part in people's daily life gradually.For researching and developing a kind of new type of disinfectant, can reach high-efficiency antimicrobial, long-acting, nontoxic production theory, be applicable to the every field in people's daily life, people begin to have given more concern and understanding to the Chinese herbal medicine disinfectant solution.This Products Development is just in order to solve the deficiency that existing disinfectant exists.This product is the composite disinfectant solution of vegetable Chinese herbal medicine essence, and pure Chinese herbal medicine essence extracts, and through the experiment screening compatibility, not only can reach the efficient sterilizing effect, and without any side effects; To the human body skin not damaged, there is not the volatilization penetrating odor; It does not have corrosion to being sterilized object; And has the long acting antibiotic effect.This invention will be guided brand-new direction to the sterilization field.

Background technology is present, and along with the raising of living standards of the people, health consciousness and conducting vigorous propaganda of the hygiene department and the social parties concerned, people's self health care and sterilizing prevent disease consciousness are strengthened gradually, and a large amount of disinfectant that directly acts on human body is answered wine and given birth to.In at present numerous disinfectant that can directly act on human body skin, mucosa, Chinese herbal disinfectant is wherein comparatively special one type.Because its Disinfection Effect is good, character is relatively gentleer, more is prone to accept for people.The disinfectant of using both at home and abroad generally all is a chemosterilant, boils stifling air disinfection method like peracetic acid, spray disinfectant air methods such as lactic acid, hydrogen peroxide, formaldehyde, but all have certain defective.Penetrating odor is arranged, and corrosivity is strong, and respiratory tract is had stimulation, and furniture, electrical equipment, metal are had infringement.For researching and developing a kind of high-effective disinfecting that reaches simultaneously; To the both harmless Chinese herbal disinfectant that does not also act on sterilizing objects of human body; The present invention is with reference to GB, disinfection technology standard and pertinent literature; The test bactericidal effect of Chinese herbal disinfectant in experiment, choose Chinese herbal medicine such as Radix Et Rhizoma Rhei, Folium Artemisiae Argyi in prepared in laboratory the compound Chinese herb disinfectant, and it has been carried out researchs such as quantitative disinfecting test, clinical on-site disinfection test.The result shows, with the Chinese herbal disinfectant of herbal prescriptions such as Radix Et Rhizoma Rhei, Folium Artemisiae Argyi staphylococcus aureus acted on 10min, and killing rate reaches 99.9%, and effect 30min can reach 100%; More than escherichia coli effect 10min, killing rate reaches 100%; The above killing rate of bacillus subtilis effect 15min is reached 99.9%; The on-the-spot sterilization in surface reaches 99.96% to bacterial inactivation rate; After placing 14d in 54 ℃ of incubators, bactericidal effect is constant basically; Organic existence has certain influence to Disinfection Effect.Theoretical and extracorporeal disinfecting result of the test is formed a compound preparation by the Chinese herbal medicine of good bactericidal effect outside the selective body escherichia coli and Salmonella enteritidis is made inactivation test and ground on-site disinfection test according to Chinese veterinarian's determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs.The result shows that the compound preparation killing colon bacillus minimal effective dose that selected Chinese herbal medicine is formed is 1: 64, is 1: 32 to Salmonella enteritidis.Said preparation uses at the scene can kill 99,90% antibacterial in 90 minutes, more than two laboratory reports show that Chinese herbal disinfectants are good disinfectant.The present invention transfers principle according to the major-minor assistant of Chinese medicine on the basis of above-mentioned research, carrying out reasonable compatibility provides a kind of novel compound disinfectant solution, and it can overcome the sterilization of disinfection technology existence in the past and deficiency that safely can not be synchronous.

Summary of the invention main points of the present invention are to adopt multiple pure natural Chinese herbal medicine essence to refine and form, and through combination principle, through grinding, soak into; Head fries in shallow oil, and fries in shallow oil again, filters; Centrifugal, blend, stir; Technologies such as decolouring are processed, and have greatly improved the pharmacological action of Chinese herbal medicine, finally process the composite disinfectant solution of a kind of vegetable Chinese herbal medicine essence.

The prescription that the present invention selects is (component and percentage by weight % thereof) as follows: Rhizoma Coptidis 4.0-6.0; Rhizoma Atractylodis Macrocephalae 1.0-3.0; Cortex Phellodendri 1.5-3.0; Cortex Magnoliae Officinalis 2.0-3.0; Radix Scutellariae 3.0-6.0; Flos Lonicerae leaf 2.0-3.0; Fructus Gardeniae 5.0-8.0; Summer millet straw 10.0-16.0; Polyhaxemethylenguanidine Hydrochloride 2.0-4.0; Lysozyme 3.0-5.0; Water to 100.0.

The Rhizoma Coptidis low concentration is antibacterial, the high concentration antibacterial, and its antibacterial action principle is: 1. destroy bacterial structure.2. suppress the antibacterial carbohydrate metabolism, Rhizoma Coptidis can suppress the oxidative deamination process of yeast and the glycometabolic intermediate link acetone acid of antibacterial.3. suppress nucleic acid, protein synthesis.Rhizoma Coptidis has broad-spectrum antibacterial action, various bacteria, tubercule bacillus and fungus etc. is had suppress or killing action.Experiment in vitro shows, Rhizoma Coptidis to staphylococcus aureus, Hemolytic streptococcus, escherichia coli, bacillus pyocyaneus, dysentery bacterium, Bacillus typhi and bacillus cloacae totally 7 kind of 16 strain pathogenic bacterium inhibitory action is all arranged.Rhizoma Coptidis and SANHUANG ZHUSHEYE (equivalent Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri are formed) also have antifungic action, and the Rhizoma Coptidis decocting liquid all has certain anti-ameba effect in external and body, multiple influenza virus and new castle disease virus are all had inhibitory action.

Rhizoma Atractylodis Macrocephalae rhizome contains volatile oil, and infusion has inhibitory action to acrothesium floccosum, star nocardia in vitro.Its decoct also has inhibitory action to meningococcus, and Bacillus typhi, paratyphoid bacillus A, shigella flexneri, escherichia coli, bacillus pyocyaneus etc. are all had bacteriostasis in various degree.

The principle of drug action of Cortex Phellodendri is that its antibiotic effective ingredient is a berberine, through influencing the synthetic of bacterial respiratory and RNA, reaches the effect of strong inhibition.Cortex Phellodendri decoct or pure preserved material in vitro tests all have inhibitory action to staphylococcus aureus, Staphylococcus albus, Staphylococcus citreus, Diplococcus pneumoniae, meningococcus, Streptococcus viridans, vibrio cholera, diphtheria corynebacterium, dysentery bacterium, bacillus pyocyaneus etc.The in vitro tests Cortex Phellodendri also has inhibitory action to tubercule bacillus, and also effective to the mycobacterium tuberculosis strain of anti-streptomycin, aminosalicylic acid, isoniazid.

The Cortex Magnoliae Officinalis decoct has broad-spectrum antibacterial action, and external all have inhibitory action to staphylococcus aureus, Hemolytic streptococcus, diphtheria corynebacterium, bacillus subtilis, dysentery bacterium, Canis familiaris L. budlet spore tinea bacterium, homocentricity trichophyton, trichophyton, trichophyton etc.; Certain anti-anthrax bacillus effect is arranged in the Cavia porcellus body.In addition, Cortex Magnoliae Officinalis is regulated effects such as smooth muscle, antiulcer, maincenter inhibition, blood pressure lowering, resisting pathogenic microbes, antitumor in addition.

But the principle of drug action of baicalin is suppressor T cell and a HIV when it is lower than cell toxicant concentration, at the beginning of HIV-1 is by cell absorption, can stop it to duplicate; The main effect link of baicalin is to disturb HIV-1 to attack target cell; Baicalin also has inhibitory action to the pathomycete of skin and fingernail.

The pharmacological action of Flos Lonicerae is that its main component that includes is flavonoid, chlorogenic acid compound dissolution Peptidoglycan; Cell wall, the cell membrane of staphylococcus aureus can be destroyed, various pathogens can be suppressed effectively: certain inhibitory action is all arranged like Hemolytic streptococcus, escherichia coli, dysentery bacterium, bacillus pyocyaneus, Bacillus typhi, Salmonella paratyphi, vibrio cholera, Diplococcus pneumoniae, meningococcus, bordetella pertussis etc.

The Fructus Gardeniae infusion can suppress various dermatophytess external; Decocting liquid then can kill leptospira and schistosomicide external, and has the effect of anti-echovirus.In that rabbit cornea implementation inoculation staphylococcus aureus is duplicated in the model experiment of keratitis, show that the curative effect and the Chibroxin of Fructus Gardeniae eye drop do not have notable difference, but on healing time, Fructus Gardeniae obviously is superior to norfloxacin.In disease popularity season or zone,,, also can play preventive effect preferably to its short treating period instant effect of acute catarrhal conjunctivitis with Fructus Gardeniae bubble drink.

Spica Prunellae has broad spectrum antibiotic activity.Water-soluble part in the ethanol extract is to the equal antibacterial and bacteriostasis of staphylococcus aureus, escherichia coli, Pseudomonas aeruginosa, bacillus subtilis, penicillium sp and aspergillus niger.Carried out the sensitivity tests to the drug resistance staphylococcus aureus through Guan Diefa, the result shows, Spica Prunellae to the antibacterial ring of drug resistance staphylococcus aureus greater than Lyphocin (Fujisawa).Employings such as the Gui Shi Tong Shi of Soviet Union culture medium discovers that the Spica Prunellae water decoction has the effect of Tuberculosis in vitro nuclear bacillus.Bai Shi etc. discover; Though the Spica Prunellae water extract has the effect of certain inhibition mycobacterium tuberculosis growth; But its ethanol extraction shows more obviously bacteriostatic activity; Show not only to exist water miscible tuberculosis composition in the Spica Prunellae that also the little composition of some polarity has the collaborative effect that suppresses tubercule bacillus in addition.

The pharmacological action of Polyhaxemethylenguanidine Hydrochloride is that guanidine radicals has very high activity; Make polymerization constitute electropositive; Be easy to be usually electronegative various antibacterial, viral adsorbed, suppressed the splitting function of bacterial virus, make antibacterial, virus forfeiture reproductive performance; Add that the thin film of polymer formation has stopped up the respiratory tract of microorganism, is choked to death microorganism rapidly.Its security performance is better, belongs to high molecular polymer, is difficult for being absorbed by animal body inner tissue, greatly reduces its toxicity, makes its cell to higher organism not have influence basically; Various materials there are not aggressivity effect, non-corrosiveness, degradable, environmentally safe.

The action principle of lysozyme is the alkaline enzyme as mucopolysaccharide in a kind of ability hydrolysis pathogenic bacterium.Mainly, make the insoluble mucopolysaccharide of cell wall resolve into the solubility glycopeptide, cause the effusion of cell wall rupture content and make bacterolysis through-acetylmuramic acid in the destruction cell wall and β-1,4 glycosidic bond between the N-n acetylglucosamine n.Lysozyme also can directly combine with electronegative virus protein, forms double salt with DNA, RNA, apoprotein, makes virally inactivated.Therefore, this enzyme has effects such as antibiotic, antiinflammatory, antiviral.

The method for preparing of product of the present invention is:

1) Rhizoma Coptidis, the Rhizoma Atractylodis Macrocephalae, Cortex Phellodendri, Cortex Magnoliae Officinalis, Radix Scutellariae, Flos Lonicerae, Fructus Gardeniae, Spica Prunellae soaked one hour through grinding;

2) slow fire is heated to after the boiling, after boiling 60 minutes, leaches the head liquid of boiling medicine;

3) add clear water again, continue slow fire and decoct, repeat 2) step 2～3 time; Leach the liquid of boiling medicine again;

4) Chinese herbal medicine fluid that leaches is mixed, 2000 rev/mins are carried out centrifugally, extract the medicinal liquid of supernatant;

5) with Polyhaxemethylenguanidine Hydrochloride, lysozyme proportional mixing be added to extract supernatant medicinal liquid in agitated reactor, mix;

6) activated carbon adsorption is discolored;

7) cool off, take the dish out of the pot, packing, warehouse-in is up to the standards;

The present invention has the following advantages:

(1) refine pure natural plant vegetable Chinese herbal medicine composition, nontoxic;

(2) antibacterial, the germ-resistant Chinese herbal medicine of the multiple epistasis of screening carries out compatibility, and the germ-resistant effect of high-efficiency broad spectrum is arranged;

(3) its abnormal smells from the patient is gentle, and is non-stimulated to human body; Body surface there is not corrosion;

(5) stable, antibiotic long-acting through experiment showed, active ingredient, long shelf-life.

The specific embodiment: the present invention is done further detailed description below in conjunction with embodiment:

Be configured according to following table institute column data (percentage by weight %) and said step thereof:

Prescription one:

Prescription two:

Prescription three:

Claims (2)

1. the present invention relates to the composite disinfectant solution of a kind of vegetable Chinese herbal medicine essence, it is characterized in that having following prescription (component and percentage by weight % thereof): Rhizoma Coptidis 4.0-6.0; Rhizoma Atractylodis Macrocephalae 1.0-3.0; Cortex Phellodendri 1.5-3.0; Cortex Magnoliae Officinalis 2.0-3.0; Radix Scutellariae 3.0-6.0; Flos Lonicerae leaf 2.0-3.0; Fructus Gardeniae 5.0-8.0; Summer millet straw 10.0-16.0; Polyhaxemethylenguanidine Hydrochloride 2.0-4.0; Lysozyme 3.0-5.0; Water to 100.0.

2. the method for preparing of the composite disinfectant solution of the said vegetable Chinese herbal medicine essence of claim 1 is characterized in that having following step:

1) Rhizoma Coptidis, the Rhizoma Atractylodis Macrocephalae, Cortex Phellodendri, Cortex Magnoliae Officinalis, Radix Scutellariae, Flos Lonicerae, Fructus Gardeniae, Spica Prunellae decocted one hour through grinding;

2) slow fire is heated to after the boiling, after boiling 60 minutes, leaches the head liquid of boiling medicine;

3) add clear water again, continue slow fire and decoct, repeat 2) step 2～3 time; Leach the liquid of boiling medicine again;

4) Chinese herbal medicine fluid that leaches is mixed, 2000 rev/mins are carried out centrifugally, extract the medicinal liquid of supernatant;

5) with Polyhaxemethylenguanidine Hydrochloride, lysozyme proportional mixing be added to extract supernatant medicinal liquid in agitated reactor, mix;

6) activated carbon adsorption is discolored;

7) cool off, take the dish out of the pot, packing, warehouse-in is up to the standards;