CN102743508B - Compound propolis composition for treating avian infectious laryngotracheitis and preparation method thereof - Google Patents
Compound propolis composition for treating avian infectious laryngotracheitis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a compound propolis composition for treating avian infectious laryngotracheitis and a preparation method thereof. The compound propolis composition is prepared by mixing 15 to 35 parts by weight of propolis, 25 to 55 parts by weight of gypsum, 15 to 35 parts by weight of folium isatidis, 10 to 35 parts by weight of isatis root, 15 to 35 parts by weight of honeysuckle, 10 to 35 parts by weight of baical skullcap root, 10 to 35 parts by weight of orange fruit, 15 to 35 parts by weight of liquorice, 15 to 35 parts by weight of tatarian aster root, and 10 to 30 parts by weight of borneol. The compound propolis composition has a reasonable formula, can be prepared by simple processes, has no toxic or side effects, does not produce pollution and drug residues, does not cause drug resistance, is crushed into superfine powder, and has high bioavailability and obvious treatment effects. In clinical, the compound propolis composition has special effects of treatment on avian infectious laryngotracheitis.
Description
Technical field
The present invention relates to bronchitic compound bee-glue composition for the treatment of chicken infectivity throat and preparation method thereof, belong to field of animal, particularly one is specifically designed to bronchitic compound bee-glue composition for the treatment of chicken infectivity throat and preparation method thereof.
Background technology
Chicken infectivity throat bronchitis is that the one caused by chicken infectivity throat bronchitis virus is acute, the contact upper respiratory infectious disease.The chicken of various age and kind all can infect, and it is characterized in that dyspnea, cough and expectoration contain the exudate of blood sample.Visible throat when cuing open inspection, tunica mucosa tracheae swelling, hemorrhage and rotten to the corn.Primary disease is propagated fast, and mortality rate is generally between 10%-30%.This disease all can occur throughout the year, and cold season autumn and winter is multiple, is one of principal disease of harm poultry husbandry.
The pathogen of primary disease is herpesvirus, and virus can be survived more than 1 year in dry environments.Under cryogenic, the time-to-live is long.This disease is all poultry countries of throughout world almost, are widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antiviral Western medicine, Chinese medicine is because its prescription is unreasonable or just simply pulverize, and particle diameter is excessive, and drug release is comparatively slow, and cause its bioavailability lower, clinical effectiveness is not fine; And various antiviral drugs such as the Ministry of Agriculture such as ribavirin, amantadine prohibits the use.
Therefore research and develop and a kind ofly treat the bronchitic drug residue free of chicken infectivity throat, the generation that has no drug resistance, the significant specific medicament of clinical effectiveness are one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe is provided, preparation is simple, micronizing, bioavailability are high, successful, to have no drug resistance and the bronchitic compound bee-glue composition of effective treatment chicken infectivity throat and preparation method thereof of drug residue.
For achieving the above object, implementation of the present invention is as follows: one treats the bronchitic compound bee-glue composition of chicken infectivity throat, by following component by weight mixed preparing form: propolis 15-35 part, Gypsum Fibrosum 25-55 part, Folium Isatidis 15-35 part, Radix Isatidis 10-35 part, Flos Lonicerae 15-35 part, Radix Scutellariae 10-35 part, Fructus Aurantii 10-35 part, Radix Glycyrrhizae 15-35 part, Radix Asteris 15-35 part, Borneolum Syntheticum 10-30 part.
Described various component optimum ratio amount is: propolis 25 parts, 50 parts, Gypsum Fibrosum, Folium Isatidis 25 parts, Radix Isatidis 25 parts, Flos Lonicerae 25 parts, Radix Scutellariae 25 parts, Fructus Aurantii 20 parts, 25 parts, Radix Glycyrrhizae, Radix Asteris 25 parts, Borneolum Syntheticum 20 parts.
Treat a preparation method for the bronchitic compound bee-glue composition of chicken infectivity throat, carry out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 15-35 part, Gypsum Fibrosum 25-55 part, Folium Isatidis 15-35 part, Radix Isatidis 10-35 part, Flos Lonicerae 15-35 part by weight, mix 5-10 minute to even;
(3) take Radix Scutellariae 10-35 part, Fructus Aurantii 10-35 part, Radix Glycyrrhizae 15-35 part, Radix Asteris 15-35 part, Borneolum Syntheticum 10-30 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, returns spleen, stomach warp, has anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, improves immunity, antiallergic is oxidized, the function of the gastrointestinal mucosa that stops blooding, protects.
Gypsum Fibrosum: sweet, pungent, cold, attaches to the lung and stomach meridians, and has the function of clearing away heat-fire, promoting the production of body fluid to quench thirst; Cure mainly fever caused by exogenous pathogenic factors, lung-heat dyspnea with rapid and short breath, the greedy drink of gastric heat, high fever coma, manic uneasiness etc.
Folium Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Cure mainly calentura and send out speckle, laryngopharynx swelling and pain, hematodiarrhoea, jaundice, carbuncle, erysipelas etc.
Flos Lonicerae: sweet, cold, returns lung, the heart, stomach warp, has the function of heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Cure mainly epidemic febrile disease heating, anemopyretic cold, cough due to lung-heat, laryngopharynx swelling and pain, toxic-heat and blood stasis, carbuncle sore tumefacting virus etc.
Radix Scutellariae: bitter, cold, returns lung, gallbladder, spleen, large intestine, small intestine meridian, has heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive function; Cure mainly that cough due to lung-heat, gastrointestinal are damp and hot, dysentery, jaundice, high heat greedyly drunk, have blood in stool, epistaxis, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus, frequent fetal movement etc.
Fructus Aurantii: bitter, pungent, sour, warm, returns stomach, spleen channel, the function have promoting the circulation of QI to alleviate the stagnation in middle-JIAO, reduce phlegm, helping digestion; Cure mainly that dyspepsia does not disappear, tripe is swollen, feces is dry, hang down de-disease, the stagnant vapour lock of expectorant etc.
Radix Glycyrrhizae: sweet, flat, returns lung, the heart, spleen channel, has invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
Radix Asteris: bitter, pungent, warm, returns lung meridian, has the function of nourishing the lung to keep the adverse QI downward, stopping coughing and removing phlegm; Cure mainly cough, abundant expectoration dyspnea with rapid respiration etc.
Radix Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Cure mainly anemopyretic cold, laryngopharynx swelling and pain, aphtha of the mouth and tongue, skin ulcer general edema with yellowish skin poison etc.
Borneolum Syntheticum: pungent, bitter, cold, GUIXIN, spleen, lung meridian, have the function of sensible refreshment, heat-clearing and fire-dispersing, reducing swelling and alleviating pain; Cure mainly coma convulsions, laryngopharynx swelling and pain, heat in the heart tongue boil, cataract, sore swollen toxin etc.
All taste Chinese medicine is according to Chinese medical theory compatible combination above, for the bronchitic pathogenic microorganism of chicken infectivity throat and clinical symptoms and pathological change, plays the effect for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and draw materials wide, micronizing, bioavailability are high, can also can drink water by spice, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this Ten Herbs, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, specially good effect is had to treatment chicken infectivity throat bronchitis, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively ensure that people's is healthy.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
One treats bronchitic compound bee-glue composition of chicken infectivity throat and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 150 parts, 250 parts, Gypsum Fibrosum, Folium Isatidis 250 parts, Radix Isatidis 100 parts, Flos Lonicerae 150 parts by weight, mix 5-10 minute to even;
(3) take Radix Scutellariae 100 parts, Fructus Aurantii 100 parts, 150 parts, Radix Glycyrrhizae, Radix Asteris 150 parts, Borneolum Syntheticum 100 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 2
One treats bronchitic compound bee-glue composition of chicken infectivity throat and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 250 parts, 400 parts, Gypsum Fibrosum, Folium Isatidis 250 parts, Radix Isatidis 150 parts, Flos Lonicerae 250 parts by weight, mix 5-10 minute to even;
(3) take Radix Scutellariae 150 parts, Fructus Aurantii 150 parts, 250 parts, Radix Glycyrrhizae, Radix Asteris 250 parts, Borneolum Syntheticum 200 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 3
One treats bronchitic compound bee-glue composition of chicken infectivity throat and preparation method thereof: carry out as follows: (every part by 10g)
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 350 parts, 550 parts, Gypsum Fibrosum, Folium Isatidis 350 parts, Radix Isatidis 350 parts, Flos Lonicerae 350 parts by weight, mix 5-10 minute to even;
(3) take Radix Scutellariae 350 parts, Fructus Aurantii 350 parts, 350 parts, Radix Glycyrrhizae, Radix Asteris 350 parts, Borneolum Syntheticum 300 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 22 ages in days, body weight at 1.0kg-1.5kg, and Laboratory Diagnosed is the bronchitic ill broiler of chicken infectivity throat.Ill chicken isolation raised separately, complete feed of feeding, and be divided into 3 groups at random, often organize 60,3 groups of feeding environments are identical, and experimental period carries out 5 days altogether; Blank group is left intact, and drug control group institute's control drug uses treatment by its description; Chinese medicine composition group of the present invention by the ill poultry of product feeding of the present invention etc., day dose be: by the every 100g of the present invention, spice 250kg feeds or the 450kg that drinks water, every day 2-3 time, is used in conjunction 3-5 day; Reached the object of disease therapy by gastrointestinal absorption after oral.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Following table is the result (testing the 5th day) at the end of experiment.
Table the present invention and other medicines are treated the bronchitic situation of chicken infectivity throat and are contrasted:
| Numbering | Group | Mortality rate % | Cure rate % | At the end of have symptom rate % |
| I | Blank group | 25.0 | 35.0 | 40.0 |
| II | HOUYANJING SAN group | 8.3 | 76.7 | 15.0 |
| III | Chinese medicine composition group of the present invention | 6.7 | 86.6 | 6.7 |
This clinical trial results statistical analysis, present composition treatment group and HOUYANJING SAN group in cure rate compared with difference extremely significantly (P < 0.01).
Safety testing:
Choose 20 age in days healthy AA broiler 60, according to the made Chinese medicine composition recommended dose of the embodiment of the present invention 1 10 times of spices or drinking-water 5 days, during medication, healthy chicken is without any bad or Deviant Behavior performance, drinking-water of searching for food is normal, and it is not remarkable that body weight increase and blank group (i.e. health not administration group) compare difference.
Above-mentioned detailed description of bronchitic compound bee-glue composition of this treatment chicken infectivity throat and preparation method thereof being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (2)
1. the bronchitic compound bee-glue composition for the treatment of chicken infectivity throat, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Gypsum Fibrosum 25-55 part, Folium Isatidis 15-35 part, Radix Isatidis 10-35 part, Flos Lonicerae 15-35 part, Radix Scutellariae 10-35 part, Fructus Aurantii 10-35 part, Radix Glycyrrhizae 15-35 part, Radix Asteris 15-35 part, Borneolum Syntheticum 10-30 part
Concrete preparation method is carried out as follows:
(1) 700 mesh sieves are crossed by after the various compositions in prescription respectively micronizing;
(2) take propolis 15-35 part, Gypsum Fibrosum 25-55 part, Folium Isatidis 15-35 part, Radix Isatidis 10-35 part, Flos Lonicerae 15-35 part by weight, mix 5-10 minute to even;
(3) take Radix Scutellariae 10-35 part, Fructus Aurantii 10-35 part, Radix Glycyrrhizae 15-35 part, Radix Asteris 15-35 part, Borneolum Syntheticum 10-30 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
2. the bronchitic compound bee-glue composition for the treatment of chicken infectivity throat according to claim 1, it is characterized in that by following component by weight mixed preparing form: propolis 25 parts, 50 parts, Gypsum Fibrosum, Folium Isatidis 25 parts, Radix Isatidis 25 parts, Flos Lonicerae 25 parts, Radix Scutellariae 25 parts, Fructus Aurantii 20 parts, 25 parts, Radix Glycyrrhizae, Radix Asteris 25 parts, Borneolum Syntheticum 20 parts.
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| CN102973668A (en) * | 2012-11-22 | 2013-03-20 | 青岛绿曼生物工程有限公司 | Compound pure traditional Chinese medicine composition for treating avian infectious laryngotracheitis and preparation method thereof |
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| CN1096206C (en) * | 1997-05-28 | 2002-12-11 | 日本电气株式会社 | Low traffic handoff method for CDMA cellular network using different frequencies among base stations |
| CN101884721A (en) * | 2010-06-28 | 2010-11-17 | 河南天纳图生物科技有限公司 | Traditional Chinese medicine for preventing and controlling respiratory diseases of animals |
| CN102357154A (en) * | 2011-11-01 | 2012-02-22 | 天津生机集团股份有限公司 | Traditional Chinese medicine composition for preventing and treating avian infectious bronchitis and preparation method thereof |
| CN102579779B (en) * | 2012-03-22 | 2014-05-28 | 郭耀亭 | Chinese medicinal composition, Chinese medicinal preparation and feed for treating and/or preventing respiratory system diseases of livestock |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096206A (en) * | 1993-06-10 | 1994-12-14 | 寿光县岔河乡畜牧兽医工作站 | Pestilence-curing medicine (Kewenning) |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1096206C (en) * | 1997-05-28 | 2002-12-11 | 日本电气株式会社 | Low traffic handoff method for CDMA cellular network using different frequencies among base stations |
| CN101884721A (en) * | 2010-06-28 | 2010-11-17 | 河南天纳图生物科技有限公司 | Traditional Chinese medicine for preventing and controlling respiratory diseases of animals |
| CN102357154A (en) * | 2011-11-01 | 2012-02-22 | 天津生机集团股份有限公司 | Traditional Chinese medicine composition for preventing and treating avian infectious bronchitis and preparation method thereof |
| CN102579779B (en) * | 2012-03-22 | 2014-05-28 | 郭耀亭 | Chinese medicinal composition, Chinese medicinal preparation and feed for treating and/or preventing respiratory system diseases of livestock |
Non-Patent Citations (1)
| Title |
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| 中药防治鸡传染性喉气管炎及支气管炎现状;岳治权;《动物医学进展》;19971231;第18卷(第4期);12-14 * |
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Effective date of registration: 20190109 Address after: 471000 No. 58 Dig Ding Road, Koudian Village, Koudian Town, Yibin District, Luoyang City, Henan Province Patentee after: Luoyang Tianmeng Biotechnology Co., Ltd. Address before: 266000 No. 66, Nan Wang Industrial Park, Licang District, Qingdao, Shandong. Patentee before: Qingdao Lvman Biological Engineering Co., Ltd. |