CN102579392A - Slow-release preparation containing tamsulosin hydrochloride and preparation method thereof - Google Patents
Slow-release preparation containing tamsulosin hydrochloride and preparation method thereof Download PDFInfo
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- CN102579392A CN102579392A CN2012100901028A CN201210090102A CN102579392A CN 102579392 A CN102579392 A CN 102579392A CN 2012100901028 A CN2012100901028 A CN 2012100901028A CN 201210090102 A CN201210090102 A CN 201210090102A CN 102579392 A CN102579392 A CN 102579392A
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Abstract
The invention discloses a slow-release preparation containing tamsulosin hydrochloride. The slow-release preparation is a combination comprising a coating and a plain film coated in the coating. The invention further provides a method for preparing the slow-release preparation containing the tamsulosin hydrochloride according to a formula. In the method, the preparation of the slow-release preparation can be completed by adopting a novel medicament formula and the conventional equipment. The tamsulosin hydrochloride slow-release preparation prepared with the method can be used for effectively controlling the in-vivo release of a medicament, the medicament is only required to be taken once every day, the medicament taking times are reduced, and the in-vivo blood concentration is stable, so that the in-vivo blood concentration of a patient in a medicament taking period is stable and effective, and the safety and effectiveness of the medicament are improved fundamentally.
Description
Technical field
The invention belongs to field of pharmaceutical preparations, particularly a kind of slow releasing preparation that contains tamsulosin hydrochloride and preparation method thereof.
Background technology
Tamsulosin hydrochloride has another name called tamsulosin hydrochloride or hydrochloric acid Tamsulosin or tamsulosin hydrochloride, chemical name 5-[(2R)-2-[2-(2-ethoxybenzene phenoxy group) ethyl ］ amino ］ propyl group ］-2-methoxybenzenesulphoismide hydrochlorate.These article are used to treat hyperplasia of prostate, belong to the blocker of epinephrine α 1 receptor subtype α 1A, and it to the affinity of α 1 receptor than the strong 5400-24000 of α 2 receptors doubly.Because α 1 receptor that urethra, bladder neck and prostate exist is mainly α 1A receptor, so these article just have the high selectivity blocking effect to urethra, neck of bladder and prostate smooth muscle, becomes clinical choice drug.
The slow releasing preparation of tamsulosin hydrochloride is released has that medicine speed is steady, little to the gastrointestinal side effect, the characteristics of long half time.The slow releasing tablet (agent) that multiple formulations and prepared tamsulosin hydrochloride are arranged in the prior art; These methods have pluses and minuses separately; Like the controlled release preparation of the disclosed hydrochloric Tamsulosin of CN101128190A, all can be in the preparation that to a certain degree solves slow releasing agent.
Summary of the invention
The purpose of this invention is to provide a kind of slow releasing preparation prescription that contains tamsulosin hydrochloride, can effectively control tamsulosin hydrochloride release in vivo.
Another object of the present invention provides a kind of method for preparing that contains the slow releasing preparation of tamsulosin hydrochloride, and this method adopts the novel drugs prescription, adopts existing equipment, can accomplish the preparation of slow releasing agent.
For realizing that the technical scheme that the object of the invention adopts is such, a kind of slow releasing preparation that contains tamsulosin hydrochloride is to comprise coating and the compositions that is wrapped in the plain sheet in the coating, and said compositions is by by weight percentage following material:
Tamsulosin hydrochloride 1～20%, slow-release material 5～60%, filmogen 0.5～10%, lubricant 0.1～5%,
Surfactant 0～10%, filler 0～55%, binding agent 0～20%, coloring agent 0～5%, wetting agent 0～45%;
Said slow-release material is selected from: hydroxypropyl methylcellulose, Sulisi aqueous dispersion, ethyl cellulose, methylcellulose, Hydroxypropyl Methylcellulose Phathalate, cellulose acetate-phthalate, hydroxypropyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, hydroxyethyl-cellulose, cellulose acetate, cellulose diacetate, Triafol T, hexadecanol, glyceryl monostearate, Brazil wax and/or hydroxy methocel;
Said filmogen is selected from: ethyl cellulose, starch, Aquacoat, methylcellulose, cellulose acetate, acrylic resin, Opadry and/or Sulisi;
Said wetting agent is selected from: water, methanol, ethanol, dehydrated alcohol, starch slurry, chloroform, acetone, polyvidone, crospolyvinylpyrrolidone and/or hydroxypropyl methylcellulose.
A kind of method for preparing that contains the slow releasing preparation of tamsulosin hydrochloride comprises A～C step:
A) plain sheet preparation:
A) get the stirring of tamsulosin hydrochloride guiding humid medium and make its dissolving, in solution, add binding agent again, fully stir, obtain principal agent solution; Said wetting agent is selected from: water, methanol, ethanol, dehydrated alcohol, starch slurry, chloroform, acetone, polyvidone, crospolyvinylpyrrolidone and/or hydroxypropyl methylcellulose, and said binding agent is selected from: water, ethanol, dehydrated alcohol, starch slurry, polyvidone, crospolyvinylpyrrolidone and/or hydroxypropyl methylcellulose;
B) filler and framework material stirring are made mix homogeneously, add the prepared principal agent solution of step a) behind the mixing, obtain mixture with wetting agent eluant container wall; Said mixture is added in the granulator, continues to stir and make into granule, take out said granule with the 12 mesh sieves granulate that wets, again with said granule after aeration-drying below 60 ℃ with 12 mesh sieve granulate;
C) with b) prepared granule and mix lubricant evenly after, with the stamping of 9mm scrobicula, Hardness Control is in 3～15KG scope;
B) coating solution preparation: filmogen is added in the water, stirred 45 minutes after adding water, make said filmogen all dissolve dispersion;
C) coating: with A) prepared plain sheet places high-efficiency coating machine, and EAT is heated to about 50 ℃～80 ℃, at the uniform velocity sprays into B) prepared coating solution carries out coating, and the sheet bed tempertaure remains on 35～45 ℃.
The disclosed tamsulosin hydrochloride of the present invention processes the slow releasing preparation prescription and technology has following advantage:
1), the slow releasing preparation rate of releasing drug is steady, near the zero level rate process, can overcome " peak valley " phenomenon that is produced behind the ordinary preparation multiple dose administration.
2), can make in the body effective blood drug concentration length of holding time, and steadily, utilization ratio of drug can reach 80～90%, and the utilization rate of conventional medicine is merely 40～60%;
3), can reduce medicine to the gastrointestinal side effect.Conventional formulation is owing to the disintegrate stripping rapidly in intestinal of oral back, and big to GI irritation, controlled release preparation of the present invention can reduce this side effect;
4), the medicine constant release time is obviously prolonged, therefore reduced medicining times, improve patient compliance, abirritate and untoward reaction.
The specific embodiment
Below in conjunction with embodiment the present invention is described further, only limits to following embodiment but should not be construed the above-mentioned subject area of the present invention.Under the situation that does not break away from the above-mentioned technological thought of the present invention, according to ordinary skill knowledge and customary means, make various replacements and change, all should comprise within the scope of the present invention.
Particularly, a kind of slow releasing preparation that contains tamsulosin hydrochloride is to comprise coating and the compositions that is wrapped in the plain sheet in the coating; Said compositions is by by weight percentage following material: tamsulosin hydrochloride 1～20%, slow-release material 5～60%, filmogen 0.5～10%; Lubricant 0.1～5%, surfactant 0～10%, filler 0～55%; Binding agent 0～20%, coloring agent 0～5%, wetting agent 0～45%; Said slow-release material is selected from: hydroxypropyl methylcellulose, Sulisi aqueous dispersion, ethyl cellulose, methylcellulose, Hydroxypropyl Methylcellulose Phathalate, cellulose acetate-phthalate, hydroxypropyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, hydroxyethyl-cellulose, cellulose acetate, cellulose diacetate, Triafol T, hexadecanol, glyceryl monostearate, Brazil wax and/or hydroxy methocel; Said filmogen is selected from: ethyl cellulose, starch, Aquacoat, methylcellulose, cellulose acetate, acrylic resin, Opadry and/or Sulisi; Said wetting agent is selected from: water, methanol, ethanol, dehydrated alcohol, starch slurry, chloroform, acetone, polyvidone, crospolyvinylpyrrolidone and/or hydroxypropyl methylcellulose.
In the embodiments of the invention, said surfactant is selected from: sodium lauryl sulphate, Stepanol MG, poloxamer and/or tween.Said filler is selected from: polyvinyl alcohol; Gather the phthalic acid vinyl acetate; Polystyrene; Carbopol; Polrvinyl chloride; Octadecanol; Diethyl phthalate; Dioctyl phthalate; Polyethylene Glycol; Sodium alginate; Chitosan; Gelatin; Lac; Pectin; Guar gum; Sucrose; Lactose; Starch; Dextrin; Icing Sugar; Low-substituted hydroxypropyl cellulose; Cross linked polyvinyl pyrrolidone; Cross-linking sodium carboxymethyl cellulose; Mannitol; Microcrystalline Cellulose; Pregelatinized Starch and/or titanium dioxide.Said binding agent is selected from: water, ethanol, dehydrated alcohol, starch slurry, polyvidone, crospolyvinylpyrrolidone and/or hydroxypropyl methylcellulose.Said coloring agent is selected from: iron oxide red, iron oxide red, amaranth, carmine, erythrosine, newly red, the lemon yellow of red, the red pigment of cowberry of red, beet red, lac, capsanthin, red rice, sunset yellow, indigo Huang and/or light blue.Said lubricant is selected from: magnesium stearate, stearic acid, micropowder silica gel, Pulvis Talci, hydrogenated vegetable oil, polyethylene glycols and/or magnesium laurylsulfate.
Embodiment also provides a kind of method for preparing that contains the slow releasing preparation of tamsulosin hydrochloride, comprises A～C step:
A) plain sheet preparation:
A) get the stirring of tamsulosin hydrochloride guiding humid medium and make its dissolving, in solution, add binding agent again, fully stir, obtain principal agent solution; Said wetting agent is selected from: water, methanol, ethanol, dehydrated alcohol, starch slurry, chloroform, acetone, polyvidone, crospolyvinylpyrrolidone and/or hydroxypropyl methylcellulose, said binding agent is selected from: water, ethanol, dehydrated alcohol, starch slurry, polyvidone, crospolyvinylpyrrolidone and/or hydroxypropyl methylcellulose.B) filler and framework material stirring are made mix homogeneously, add the prepared principal agent solution of step a) behind the mixing, obtain mixture with wetting agent eluant container wall; Said mixture is added in the granulator, continues to stir and make into granule, take out said granule with the 12 mesh sieves granulate that wets, again with said granule after aeration-drying below 60 ℃ with 12 mesh sieve granulate.C) with b) prepared granule and mix lubricant evenly after, with the stamping of 9mm scrobicula, Hardness Control is in 3～15KG scope.
B) coating solution preparation: filmogen is added in the water, stirred 45 minutes after adding water, make said filmogen all dissolve dispersion.
C) coating: with A) prepared plain sheet places high-efficiency coating machine, and EAT is heated to about 50 ℃～80 ℃, at the uniform velocity sprays into B) prepared coating solution carries out coating, and the sheet bed tempertaure remains on 35～45 ℃.
Below enumerated through embodiment 1～4 and to adopt prescription of the present invention and method to prepare slow releasing tablet, adopt drug release determination method detection in the national drug quality standard, the result shows:
Embodiment 1:
Prescription:
| Tamsulosin hydrochloride | 10g |
| Copolyvidone | 20g |
| Microcrystalline Cellulose | 40 |
| Sucrose | 80g |
| Hypromellose | 50g |
| Magnesium stearate | 2g |
| Methanol | In right amount |
| Opadry | 10 g |
| Water | In right amount |
| Process | 1000 |
Preparation process:
1 plain sheet preparation technology
1.1 preparation contains the principal agent binding agent
Get tamsulosin hydrochloride 10g and add methanol 60g and stir and to make dissolving, add the 20g copolyvidone again and stir and make dissolving, lucifuge is placed subsequent use.
1.2 granulate
Sucrose is pulverized, crossed 80 mesh sieves, together pack in the wet mixing pelletizer with microcrystalline Cellulose, hypromellose again; Stirring makes mix homogeneously, adds the binding agent that contains principal agent behind the mixing and granulates, with an amount of washed with methanol chamber wall; And in the adding granulator, continue to stir and to make into granule, take out granule with the 12 mesh sieves granulate that wets; Granule after aeration-drying below 50 ℃ with 12 mesh sieve granulate, subsequent use.
1.3 tabletting
With the magnesium stearate of granule that makes and formula ratio, behind the mix homogeneously, detection level confirms that sheet is heavy, and with the stamping of 9mm scrobicula, Hardness Control is in 5～10KG scope.
2 art for coating
2.1 the preparation of coating solution
The formula ratio Opadry is added in the water, and it is an amount of to add water, stirred 45 minutes, whole dissolvings are disperseed, be mixed with Opadry concentration and be 15% homogeneous aqueous dispersion, subsequent use.
2.2 coating
The plain sheet that makes is put in the high-efficiency coating machine, and EAT is heated to about 60 ℃～90 ℃, at the uniform velocity sprays into the coating solution coating, and the sheet bed tempertaure remains on 30～45 ℃, and it is about 5% that coating increases weight, and promptly gets.
Embodiment 2:
Prescription:
| Tamsulosin hydrochloride | 15g |
| Polyvidone | 20g |
| Microcrystalline Cellulose | 40g |
| Sucrose | 40g |
| Ethyl cellulose | 40g |
| Starch | 40g |
| Pulvis Talci | 2g |
| Ethanol | In right amount |
| Opadry | 5 g |
| Water | In right amount |
| Process | 1000 |
Preparation process:
1 plain sheet preparation technology
1.1 preparation contains the principal agent binding agent
Get tamsulosin hydrochloride 15g and add ethanol 70g and stir and to make dissolving, add the 20g polyvidone again and stir and make dissolving, lucifuge is placed subsequent use.
1.2 granulate
Sucrose is pulverized, crossed 80 mesh sieves, together pack in the wet mixing pelletizer with microcrystalline Cellulose, ethyl cellulose, starch again; Stirring makes mix homogeneously, adds the binding agent that contains principal agent behind the mixing and granulates, with an amount of alcohol flushing chamber wall; And in the adding granulator; Continue to stir and to make into granule, take out granule with the 12 mesh sieves granulate that wets, granule is in aeration-drying below 60 ℃.Dried particles is carried out moisture content detect, detect qualified (granule moisture content is less than 3%) back with 12 mesh sieve granulate, subsequent use.
1.3 tabletting
With the Pulvis Talci of granule that makes and formula ratio, behind the mix homogeneously, detection level confirms that sheet is heavy, and with the stamping of 9mm scrobicula, Hardness Control is in 6～14KG scope.
2 art for coating
2.1 the preparation of coating solution
The formula ratio Opadry is added in the water, and it is an amount of to add water, stirred 60 minutes, whole dissolvings are disperseed, be mixed with Opadry concentration and be 20% homogeneous aqueous dispersion, subsequent use.
2.2 coating
The plain sheet that makes is put in the high-efficiency coating machine, and EAT is heated to about 60 ℃～80 ℃, at the uniform velocity sprays into the coating solution coating, and the sheet bed tempertaure remains on 30～45 ℃, and it is about 2.5% that coating increases weight, and promptly gets.
Embodiment 3:
Prescription:
| Tamsulosin hydrochloride | 10g |
| Copolyvidone | 20g |
| Polyethylene Glycol | 40g |
| Sucrose | 52g |
| Sodium alginate | 75g |
| Stearic acid | 2g |
| Chloroform | In right amount |
| Sulisi | 6 g |
| Water | In right amount |
| Process | 1000 |
Preparation process:
1 plain sheet preparation technology
1.1 preparation contains the principal agent binding agent
Get tamsulosin hydrochloride 10g and add chloroform 53g and stir and to make dissolving, add the 20g copolyvidone again and stir and make dissolving, lucifuge is placed subsequent use.
1.2 granulate
Sucrose is pulverized, and it is subsequent use to cross 80 mesh sieves.Get the cane sugar powder and the Polyethylene Glycol of formula ratio and cross 40 mesh sieve premixs, together pack in the wet mixing pelletizer with the shallow lake sodium alginate again, stir and make mix homogeneously; Add the binding agent that contains principal agent behind the mixing and granulate,, and add in the granulator with an amount of chloroform eluant container wall; Continue to stir and make into granule; Take out granule with the 12 mesh sieves granulate that wets, granule after aeration-drying below 50 ℃ with 12 mesh sieve granulate, subsequent use.
1.3 tabletting
With the stearic acid of granule that makes and formula ratio, behind the mix homogeneously, detection level confirms that sheet is heavy, and with the stamping of 9mm scrobicula, Hardness Control is in 3～7KG scope.
2 art for coating
2.1 the preparation of coating solution
The formula ratio Sulisi is added in the water, and it is an amount of to add water, stirred 45 minutes, whole dissolvings are disperseed, be mixed with Sulisi concentration and be 5% homogeneous aqueous dispersion, subsequent use.
2.2 coating
The plain sheet that makes is put in the high-efficiency coating machine, and EAT is heated to about 50 ℃～80 ℃, at the uniform velocity sprays into the coating solution coating, and the sheet bed tempertaure remains on 35～45 ℃, and it is about 3% that coating increases weight, and promptly gets.
Embodiment 4
Prescription:
| Plain slice prescription: | ? |
| Tamsulosin hydrochloride | 5g |
| Polyvidone | 20g |
| Sucrose | 110g |
| Hydroxypropyl cellulose | 65g |
| Methylcellulose | 5g |
| Polyethylene glycol 6000 | 0.5g |
| The moon is hung pure magnesium sulfate | 2g |
| Ferrum oxide | 0.5g |
| Dehydrated alcohol | In right amount |
| Process | 1000 |
Preparation technology:
Get the formula ratio tamsulosin hydrochloride and pulverize ultrasonic dissolution in the adding 90ml dehydrated alcohol, add the formula ratio polyvidone, subsequent use after the stirring and dissolving.Formula ratio sucrose is pulverized back and hydroxypropyl cellulose drop into the wet-mixed comminutor and do and mix 2min, add tamsulosin hydrochloride polyvidone ethanol solution and process granule, 60 ℃ of oven dry are sneaked into behind the granulate and month are hung 9mm stamping behind the pure magnesium sulfate mixing.Get methylcellulose 5g, polyethylene glycol 6000 0.5g is dissolved in the 100ml dehydrated alcohol, and it is subsequent use to sneak into ferrum oxide 0.5g.When the coating pan temperature reaches 40 ℃, begin to spray into coating solution, cooperate hot blast drying, packing promptly gets behind the coating.
Claims (3)
1. slow releasing preparation that contains tamsulosin hydrochloride is to comprise coating and the compositions that is wrapped in the plain sheet in the coating, it is characterized in that: said compositions is by by weight percentage following material:
Tamsulosin hydrochloride 1～20%, slow-release material 5～60%, filmogen 0.5～10%, lubricant 0.1～5%,
Surfactant 0～10%, filler 0～55%, binding agent 0～20%, coloring agent 0～5%, wetting agent 0～45%;
Said slow-release material is selected from: hydroxypropyl methylcellulose, Sulisi aqueous dispersion, ethyl cellulose, methylcellulose, Hydroxypropyl Methylcellulose Phathalate, cellulose acetate-phthalate, hydroxypropyl cellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, hydroxyethyl-cellulose, cellulose acetate, cellulose diacetate, Triafol T, hexadecanol, glyceryl monostearate, Brazil wax and/or hydroxy methocel;
Said filmogen is selected from: ethyl cellulose, starch, Aquacoat, methylcellulose, cellulose acetate, acrylic resin, Opadry and/or Sulisi;
Said wetting agent is selected from: water, methanol, ethanol, dehydrated alcohol, starch slurry, chloroform, acetone, polyvidone, crospolyvinylpyrrolidone and/or hydroxypropyl methylcellulose.
2. a kind of slow releasing preparation that contains tamsulosin hydrochloride according to claim 1 is characterized in that:
Said surfactant is selected from: sodium lauryl sulphate, Stepanol MG, poloxamer and/or tween,
Said filler is selected from: polyvinyl alcohol; Gather the phthalic acid vinyl acetate; Polystyrene; Carbopol; Polrvinyl chloride; Octadecanol; Diethyl phthalate; Dioctyl phthalate; Polyethylene Glycol; Sodium alginate; Chitosan; Gelatin; Lac; Pectin; Guar gum; Sucrose; Lactose; Starch; Dextrin; Icing Sugar; Low-substituted hydroxypropyl cellulose; Cross linked polyvinyl pyrrolidone; Cross-linking sodium carboxymethyl cellulose; Mannitol; Microcrystalline Cellulose; Pregelatinized Starch and/or titanium dioxide
Said binding agent is selected from: water, ethanol, dehydrated alcohol, starch slurry, polyvidone, crospolyvinylpyrrolidone and/or hydroxypropyl methylcellulose,
Said coloring agent is selected from: iron oxide red, iron oxide red, amaranth, carmine, erythrosine, newly red, the lemon yellow of red, the red pigment of cowberry of red, beet red, lac, capsanthin, red rice, sunset yellow, indigo Huang and/or light blue,
Said lubricant is selected from: magnesium stearate, stearic acid, micropowder silica gel, Pulvis Talci, hydrogenated vegetable oil, polyethylene glycols and/or magnesium laurylsulfate.
3. method for preparing that contains the slow releasing preparation of tamsulosin hydrochloride comprises A～C step:
A) plain sheet preparation:
A) get the stirring of tamsulosin hydrochloride guiding humid medium and make its dissolving, in solution, add binding agent again, fully stir, obtain principal agent solution; Said wetting agent is selected from: water, methanol, ethanol, dehydrated alcohol, starch slurry, chloroform, acetone, polyvidone, crospolyvinylpyrrolidone and/or hydroxypropyl methylcellulose, and said binding agent is selected from: water, ethanol, dehydrated alcohol, starch slurry, polyvidone, crospolyvinylpyrrolidone and/or hydroxypropyl methylcellulose;
B) the filler stirring is made mix homogeneously, add the prepared principal agent solution of step a) behind the mixing, obtain mixture with wetting agent eluant container wall; Said mixture is added in the granulator, continues to stir and make into granule, take out said granule with the 12 mesh sieves granulate that wets, again with said granule after aeration-drying below 60 ℃ with 12 mesh sieve granulate;
C) with b) prepared granule and mix lubricant evenly after, with the stamping of 9mm scrobicula, Hardness Control is in 3～15KG scope;
B) coating solution preparation: filmogen is added in the water, stirred 45 minutes after adding water, make said filmogen all dissolve dispersion;
C) coating: with A) prepared plain sheet places high-efficiency coating machine, and EAT is heated to about 50 ℃～80 ℃, at the uniform velocity sprays into B) prepared coating solution carries out coating, and the sheet bed tempertaure remains on 35～45 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100901028A CN102579392A (en) | 2012-03-30 | 2012-03-30 | Slow-release preparation containing tamsulosin hydrochloride and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100901028A CN102579392A (en) | 2012-03-30 | 2012-03-30 | Slow-release preparation containing tamsulosin hydrochloride and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102579392A true CN102579392A (en) | 2012-07-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012100901028A Pending CN102579392A (en) | 2012-03-30 | 2012-03-30 | Slow-release preparation containing tamsulosin hydrochloride and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106619481A (en) * | 2015-10-30 | 2017-05-10 | 四川科瑞德制药股份有限公司 | Long-acting 5-HT1A receptor stimulant and preparation method thereof |
| CN108065408A (en) * | 2017-10-25 | 2018-05-25 | 北京康力基生物科技有限公司 | A kind of composition containing collagen and preparation method thereof |
| CN115518043A (en) * | 2022-10-12 | 2022-12-27 | 江苏集萃新型药物制剂技术研究所有限公司 | Controlled release composition, granules, tablets and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1589139A (en) * | 2001-11-07 | 2005-03-02 | 斯索恩有限公司 | Modified release tamsulosin tablets |
| CN101596171A (en) * | 2009-06-25 | 2009-12-09 | 昆明积大制药有限公司 | A kind of tamsulosin sustained release tablet and preparation method thereof |
| WO2010136193A1 (en) * | 2009-05-28 | 2010-12-02 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Pharmaceutical composition comprising tamsulosin |
-
2012
- 2012-03-30 CN CN2012100901028A patent/CN102579392A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1589139A (en) * | 2001-11-07 | 2005-03-02 | 斯索恩有限公司 | Modified release tamsulosin tablets |
| CN1652760A (en) * | 2001-11-07 | 2005-08-10 | 斯索恩有限公司 | Tamsulosin tablets |
| WO2010136193A1 (en) * | 2009-05-28 | 2010-12-02 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Pharmaceutical composition comprising tamsulosin |
| CN101596171A (en) * | 2009-06-25 | 2009-12-09 | 昆明积大制药有限公司 | A kind of tamsulosin sustained release tablet and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106619481A (en) * | 2015-10-30 | 2017-05-10 | 四川科瑞德制药股份有限公司 | Long-acting 5-HT1A receptor stimulant and preparation method thereof |
| CN106619481B (en) * | 2015-10-30 | 2021-07-13 | 四川科瑞德制药股份有限公司 | Long-acting 5-HT1A receptor agonist and preparation method thereof |
| CN108065408A (en) * | 2017-10-25 | 2018-05-25 | 北京康力基生物科技有限公司 | A kind of composition containing collagen and preparation method thereof |
| CN115518043A (en) * | 2022-10-12 | 2022-12-27 | 江苏集萃新型药物制剂技术研究所有限公司 | Controlled release composition, granules, tablets and preparation method thereof |
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Application publication date: 20120718 |