CN102565436B - Self-calibration multi-measurement module of portable detecting instrument, and using method thereof - Google Patents
Self-calibration multi-measurement module of portable detecting instrument, and using method thereof Download PDFInfo
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- CN102565436B CN102565436B CN 201210017394 CN201210017394A CN102565436B CN 102565436 B CN102565436 B CN 102565436B CN 201210017394 CN201210017394 CN 201210017394 CN 201210017394 A CN201210017394 A CN 201210017394A CN 102565436 B CN102565436 B CN 102565436B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48785—Electrical and electronic details of measuring devices for physical analysis of liquid biological material not specific to a particular test method, e.g. user interface or power supply
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
- G01N35/00594—Quality control, including calibration or testing of components of the analyser
- G01N35/00693—Calibration
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/02—Adapting objects or devices to another
- B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0621—Control of the sequence of chambers filled or emptied
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0633—Valves, specific forms thereof with moving parts
- B01L2400/065—Valves, specific forms thereof with moving parts sliding valves
Abstract
The invention discloses a self-calibration multi-measurement module of a portable detecting instrument, and a using method of the module. The self-calibration multi-measurement module comprises a base, a movable detection module, a fixed module, a calibration solution pool and a waste liquid pool. The using method of the module comprises the following steps of: a) calibrating calibration solution; and b) detecting liquid to be detected. The invention provides the method and the multi-measurement module which are simple and effective; after being arranged in the portable detecting instrument, one measurement module can be used for measuring samples for hundreds of times; the whole complexity of the module is far lower than that of the existing modular instrument; and the module not only has simplicity and miniaturization of a dry chip instrument, but also has the high reliability and a multi-measurement characteristic of the modular instrument.
Description
Technical field
The present invention relates to the liquid detecting technical field, relate in particular a kind of self calibration for portable instrumentation repeatedly measurement module and using method thereof.
Background technology
The fields such as current medical diagnosis, commercial production, environmental protection all need to measure rapidly and accurately at the scene; all be very important to first aid, diagnosis, accident treatment, process monitoring etc.; many times or even of vital importance; therefore, field quick detection also is the present domestic field of giving priority to analysis and detecting instrument in the world.
In this technical field, mainly be divided into two classes, one class is with instrument miniaturization, integrated, the outside attached device that connects of cancellation traditional instrument such as reagent bottle, calibration solution, injector, detecting device, these parts completely are designed to module, and be integrated into a less instrument internal, form the integral body that can move easily (for example patent No.: US 5750881,5580790,5637275 United States Patent (USP)).Particularly to (or number of times) limited parts in serviceable life wherein, such as sensor, pack etc., adopt detachable mounted consumptive material pack mode, provide in the mode of consumptive material, can change at any time, do not need the complicated calibration operation of safeguarding.Its operation is very easy, the consumptive material bag can provide repeatedly continuous coverage, shortcoming is to stablize the indoor environment use, must use AC power, the reusable version sensor of its configuration generally can not provide the facility of plug and play, needs startup and the stabilization time of long period, the more important thing is, its volume is relatively large, and is even a people can move, very inconvenient but it carries, transports.End is got up, it mainly is that the development and application of modern technologies has been arrived in system and the miniaturization, with traditional large-scale instrument miniaturization, integrated, thereby the field of employment has been pushed ahead the occasion of operating room and ward one class from central laboratory, thereby can be in the on-the-spot directly measurement of sample collection.
Equations of The Second Kind is that instrument itself and measuring unit are separated, instrument itself is carried out repeatedly and is measured, but need to finish the necessary reagent of one-time detection, calibration solution and detecting device and focus on a less unit, form disposable chip, each measurement need to couple together a chip and instrument, after finishing chip is discarded (for example patent No. US 5096669,6750053,7419821 United States Patent (USP)).The characteristics of this method are that instrument part is only carried out the electronic signal translation function, do not relate to chemical reagent and liquid handling, so instrument itself can make very littlely, reach hand-held size, more convenient scene even open-air the use.This system is because its chip contains and all finishes the required element of one-shot measurement, not needing provides reagent in addition, so be called again " dry type " chip, its most outstanding advantage is plug and play, do not need any maintenance and special operational, convert the instrument use procedure to deprofessionalization fully.Any medical personnel all can use whenever and wherever possible, use in any place.Its shortcoming mainly is that each measurement chip can only use once, has obvious inferior position at average single measurement cost, especially the situation that needs continuous several times to measure, the inferior position of its cost is more obvious, operation also seems very loaded down with trivial details, need to change frequently chip, so it is to tend to the frequent user who does not still need to be equipped with again front a kind of instrument of access times.
These two kinds of classic methods that method compares, main advantage all provides convenience, actual increasing on the single use cost, and the waste of material that produces and also to some extent increase of discarded object.
And at present in this technical field, there is no and can be repeatedly used, and possess conveniently, low-cost, need not safeguard the high benefit of characteristics, the hand-held chip type analytical instrument of hi-tech.
Summary of the invention
The purpose of this invention is to provide a kind of self calibration for portable instrumentation repeatedly measurement module and using method thereof, its needs are installed in the portable instrumentation, just can realize reaching hundreds of times sample measurements, operate very simple, the single measurement cost is low, measuring accuracy is high.
Another object of the present invention provides a kind of portable instrumentation, and it is simple to operate, has both comprised the simple and easy and microminiaturized of dry type chip type instrument, has comprised again the high reliability of modular instrument and measurement characteristics repeatedly.
In order to solve the problems of the technologies described above, technical scheme of the present invention is as follows: the self calibration of portable instrumentation is measurement module repeatedly,
Comprise a base;
One is arranged on the stuck-module on the described base;
The one mobile detection module with detecting sensor for detection of calibration solution and detected liquid;
The one calibration liquid pool that can deposit the calibration solution of enough volumes and be communicated with and when described mobile detection module is positioned at the precalculated position, can be communicated with described mobile detection module with described stuck-module;
One is used for depositing calibration solution after the detection and the waste liquid pool of detected liquid.
As preferably, described mobile detection module comprises movable block, be provided with measuring cell in the described movable block, detecting sensor for detection of liquid in the measuring cell is arranged in the described measuring cell, and described movable block is provided with the detected liquid that is communicated with described measuring cell and waste liquid capillary mozzle, calibration solution capillary mozzle.
As preferably, described stuck-module is positioned at the place ahead of described mobile detection module, it comprises two detected liquid line enclosed elastic modules, when described detected liquid and waste liquid capillary mozzle free open end are in one of them when inner, described detected liquid and waste liquid capillary mozzle are closed; Described stuck-module also comprises a detected liquid connector that can be connected with described detected liquid and waste liquid capillary mozzle and a calibration solution passage that is communicated with described calibration liquid pool; Between described two detected liquid line enclosed elastic modules the fluid passage that is communicated with described waste liquid pool is arranged; Described detected liquid connector is arranged in the place ahead of forward that of described two detected liquid line enclosed elastic modules; The place ahead of described calibration solution passage is provided with calibration tube enclosed elastic module, and when described calibration solution capillary mozzle free open end was in wherein, described calibration solution capillary mozzle was closed.
As preferably, described detected liquid line enclosed elastic module comprises two the first elastomer block of being made by resilient material, two adjacent sides of described two the first elastomer block fit, form the seam of fitting, described detected liquid and waste liquid capillary mozzle are aimed in the centre position of described applying seam.
As preferably, the fit rear end of seam of described two the first elastomer block is provided with the first pre-small post-large guiding structure.
As preferably, described stuck-module also comprises two O type circles that can be passed by described detected liquid and waste liquid capillary mozzle, the internal diameter of described two O type circles is less than the external diameter of described detected liquid and waste liquid capillary mozzle, the internal diameter of described two O type circles is less than the external diameter of described detected liquid and waste liquid capillary mozzle, and described one or two O type circle is separately positioned on the rear of described two detected liquid line enclosed elastic modules and fits with it.
As preferably, the internal diameter of a described O type circle be described detected liquid and waste liquid capillary mozzle external diameter 0.75-0.95 doubly.
As preferably, described the first elastomer block is made by elastic caoutchouc or elastoplast or polyurethane.
As preferably, described calibration tube enclosed elastic module comprises two elastic bodys of being made by resilient material, two adjacent sides of described two elastic bodys fit, form the seam of fitting, described calibration solution capillary mozzle is aimed in the centre position of described applying seam, be provided with an O RunddichtringO that can be passed by described calibration solution capillary mozzle in the described calibration solution passage, the opening that is communicated with described calibration liquid pool of described calibration solution passage is between described O RunddichtringO and described two elastic bodys.
As preferably, be provided with the front O RunddichtringO of fitting with it and can be passed by described calibration solution capillary mozzle in described two elastomeric rear ends; The internal diameter of described front O RunddichtringO is 0.75-0.95 times of described calibration solution capillary mozzle external diameter.
As preferably, be provided with pre-small post-large guiding structure in the rear end of described two elastic bodys applying seam.
As preferably, the internal diameter of described O RunddichtringO be described calibration solution capillary mozzle external diameter 0.75-0.95 doubly.
As preferably, described elastic body is made by elastic caoutchouc or elastoplast or polyurethane.
As preferably, described detected liquid and waste liquid capillary mozzle, calibration solution capillary mozzle are made by stainless steel or plastics.
As preferably, described mobile detection module comprises movable block, be provided with measuring cell in the described movable block, described detecting sensor for detection of liquid in the described measuring cell is arranged in the described measuring cell, and described movable block is provided with calibration solution and the detected liquid capillary mozzle that is communicated with described measuring cell.
As preferably, described stuck-module is positioned at the place ahead of described mobile detection module, it comprises two enclosed elastic modules, and when the free open end of described calibration solution and detected liquid capillary mozzle was in one of them inside, described calibration solution and detected liquid capillary mozzle were closed; Described stuck-module also comprises detected liquid connector and a passage that is communicated with described calibration liquid pool that can be connected with described calibration solution and detected liquid capillary mozzle, described passage is between described two enclosed elastic modules, and described detected liquid connector is arranged in the place ahead of forward that of described two enclosed elastic modules.
As preferably, described enclosed elastic module comprises two the second elastomer block of being made by resilient material, two adjacent sides of described two the second elastomer block fit, and form the seam of fitting, and described calibration solution and detected liquid capillary mozzle are aimed in the centre position of described applying seam.
As preferably, the fit rear end of seam of described two the second elastomer block is provided with the second pre-small post-large guiding structure.
As preferably, described stuck-module also comprises two O type circles that can be passed by described calibration solution and detected liquid capillary mozzle, described two O type circles are separately positioned on the rear of described two enclosed elastic modules and fit with it, and described two O type circle internal diameters are less than the external diameter of described calibration solution and detected liquid capillary mozzle.
As preferably, the internal diameter of described O type circle be described calibration solution and detected liquid capillary mozzle external diameter 0.75-0.95 doubly.
As preferably, described the second elastomer block is made by elastic caoutchouc or elastoplast or polyurethane.
As preferably, described calibration solution and detected liquid capillary mozzle are made by stainless steel or plastics.
As preferably, described calibration liquid pool and described waste liquid pool are to be arranged on two cavity volumes of base bottom or to be arranged on two containers on the base.
As preferably, described base is provided with a case.
A kind of portable instrumentation, described portable instrumentation comprise repeatedly measurement module of above-mentioned self calibration.
A kind of self calibration of portable instrumentation is the using method of measurement module repeatedly, comprises following steps:
A) calibration solution calibration; Described mobile detection module arrives the precalculated position and is communicated with the calibration liquid pool, the suction calibration solution enters mobile detection module in the liquid pool from calibrating, then calibration solution is entered waste liquid pool, be discharged in the process of waste liquid pool at calibration solution, calibration solution detects through detecting sensor, and the result that detecting sensor will detect issues the signal processing unit of portable instrumentation with the form of electric signal;
B) detected liquid detecting; Described mobile detection module arrives precalculated position and detected fluid connection, suck detected liquid and enter mobile detection module, after the detecting sensor detection, the result that detecting sensor will detect issues the signal processing unit of portable instrumentation with the form of electric signal, the detected liquid after then will detecting enters waste liquid pool.
As preferably, also comprise flushing and the secondary calibration of step c); The described precalculated position that described mobile detection module arrives in the described step a) is communicated with the calibration liquid pool, the suction calibration solution enters mobile detection module in the liquid pool from calibrating, then the calibration solution after will detecting enters waste liquid pool, realizes to the flushing of mobile detection module with to the secondary calibration of detecting sensor.
A kind of self calibration of portable instrumentation is the using method of measurement module repeatedly, comprises following steps:
A) calibration solution calibration; Described mobile detection module arrives the precalculated position and is communicated with the calibration liquid pool, the suction calibration solution enters mobile detection module in the liquid pool from calibrating, after the detecting sensor detection, the result that detecting sensor will detect issues the signal processing unit of portable instrumentation with the form of electric signal, the calibration solution after then will detecting enters waste liquid pool;
B) detected liquid detecting; Described mobile detection module arrives precalculated position and detected fluid connection, suck detected liquid and enter mobile detection module, after the detecting sensor detection, the result that detecting sensor will detect issues the signal processing unit of portable instrumentation with the form of electric signal, the detected liquid after then will detecting enters waste liquid pool.
As preferably, also comprise flushing and the secondary calibration of step c); Described mobile detection module arrives the precalculated position described in the described step a) and is communicated with the calibration liquid pool, the suction calibration solution enters mobile detection module in the liquid pool from calibrating, then the calibration solution after will detecting enters waste liquid pool, realizes to the flushing of mobile detection module with to the secondary calibration of detecting sensor.
Beneficial effect of the present invention is: the invention provides a kind of simple, effective method and measurement module, a measurement module is packed into behind the portable instrumentation, can finish and reach hundreds of times sample measurement, its overall complexity is well below the instrument of present modularity, both comprised the simple and easy and microminiaturized of dry type chip type instrument, comprised again the high reliability of modular instrument and measurement characteristics repeatedly, the single testing cost is very low.
Description of drawings
The present invention is described further below in conjunction with accompanying drawing:
Fig. 1 is profile schematic diagram of the present invention;
Fig. 2 is the structural representation of the embodiment of the invention 1; Detected liquid and waste liquid capillary mozzle are in the state of being closed among the figure;
Fig. 3 is that mobile detection module advances that rear calibration solution capillary mozzle is closed in the embodiment of the invention 1, detected liquid and waste liquid capillary mozzle be in the view that is communicated with waste liquid pool;
Fig. 4 is that mobile detection module advances that rear calibration solution capillary mozzle is closed in the embodiment of the invention 1, detected liquid and waste liquid capillary mozzle be in the view that is communicated with detected liquid connector;
Fig. 5 is the structural representation of the second embodiment of the present invention, and figure alignment liquid and detected liquid capillary mozzle are communicated with the calibration liquid pool;
Fig. 6 is that calibration solution and the detected liquid capillary mozzle of the second embodiment of the present invention is communicated with schematic diagram with detected liquid connector;
Among the figure:
The 1-base;
2-moves detection module;
The 201-movable block, 202-measuring cell, the detected liquid of 203-and waste liquid capillary mozzle, 204-the first flexible pipe, 205-calibration solution capillary mozzle, 206-calibration solution and detected liquid capillary mozzle, 207-the second flexible pipe;
The 3-linear conveying device;
The 4-stuck-module; 401-is detected liquid line enclosed elastic module, 401a-the first elastomer block, 401b-the first guiding structure, 402-is detected liquid connector, 403-calibration solution passage, 404-fluid passage, 405-calibration tube enclosed elastic module, 405a-elastic body, 405b-guiding structure, 406-the one O type circle, 407-O RunddichtringO, 408-enclosed elastic module, 408a-the second elastomer block, 408b-the second guiding structure, 409-passage, O RunddichtringO before the 410-O type circle, 411-;
5-calibrates liquid pool;
The 6-micropump; The 601-cavity, 602-pump case, 603-import, 604-piston, 605-straight line conveyer structure;
The 7-waste liquid pool;
The 8-detecting sensor;
The 9-case.
Embodiment
The following stated is preferred embodiment of the present invention only, is not that scope of the present invention is limited.
Embodiment 1, see accompanying drawing 1,2,3,4, accompanying drawing 2 is the structural representation of measurement module in the present embodiment, wait in use, it is installed in the portable instrumentation with regard to the portable instrumentation of complete, can have used, it comprises a base 1 measurement module, one case 9 is installed on the base 1, and each components and parts that are mainly used to be installed on the base 1 protect; Comprise that also one is arranged on the stuck-module 4 on the base 1, base 1 have one can deposit enough volume calibration solutions for detection of calibration solution and the mobile detection module 2 with detecting sensor 8 and of detected liquid and the calibration liquid pool 5, that is communicated with described stuck-module 4 and when described mobile detection module 2 is positioned at the precalculated position, can be communicated with described detection module 2 after being used for depositing detection calibration liquid and the waste liquid pool 7 of detected liquid.Also be provided with in addition micropump 6 for delivery of calibration liquid and detected liquid in the portable instrumentation so that mobile detection module 2 can be done at described base 1 linear conveying device 3 of straight reciprocating motion, use matches with measurement module.In the present embodiment, calibration liquid pool 5 is two cavity volumes that are arranged on base 1 bottom with waste liquid pool 7, two containers can certainly be set to be served as, these two containers can be fixed, and also can be dismountable, wherein, the solvent of waste liquid pool 7 is greater than calibration liquid pool 5, calibration liquid pool 5 interior number of times and each amounts of using according to using arrange enough calibration solutions, and general amount is that enough detections are advisable for about 500 times.
Mobile detection module 2 is driven by linear conveying device 3, do straight reciprocating motion at base 1, linear conveying device is linear electric motors, minitype cylinder, miniature electromotive handspike, also can be that other known can realize the device of straight reciprocating motion or components and parts etc., it is arranged in the portable instrumentation, what generally adopt is linear electric motors, mobile detection module 2 comprises movable block 201, movable block 201 is fixedly connected with linear electric motors, drive the realization straight reciprocating motion by linear electric motors, be provided with measuring cell 202 in the movable block 201, detecting sensor 8 for detection of measuring cell 202 interior liquid is arranged in the measuring cell 202, measuring cell 202 is the places for Measurement and calibration liquid and detected liquid, detecting sensor 8 is connected with the signal processing unit of portable instrumentation simultaneously, the result who detects can be issued the signal processing unit of portable instrumentation with the form of electric signal, compared by signal processing unit, movable block 201 is provided with detected liquid and waste liquid capillary mozzle 203 and the calibration solution capillary mozzle 205 that is communicated with measuring cell 202, detected liquid and waste liquid capillary mozzle 203, calibration solution capillary mozzle 205 is fixed on the place ahead of movable block 201, and micropump 6 imports 603 also are communicated with measuring cell 202, and calibration solution capillary mozzle 205 is parallel to each other with detected liquid and waste liquid capillary mozzle 203.In the present embodiment, measuring cell 202 has two openings, one is communicated with detected liquid and waste liquid capillary mozzle 203, another is communicated with micropump 6 imports 603, calibration solution capillary mozzle 205, detecting sensor 8 is then between these two openings, detected liquid and waste liquid capillary mozzle 203, calibration solution capillary mozzle 205 all are hard capillary mozzles, are made by stainless steel or plastics.Because mobile detection module 2 moves, so, be communicated with by the second flexible pipe 207 between mobile detection module 2 and micropump 6 imports 603.
In the present embodiment, the micropump 6 that is arranged in the portable instrument is ram pump, it comprises the pump case 602 with cavity 601, pump case is cylindric, import 603 is arranged on the pump case 602, and communicate with cavity 601, one piston 604 is arranged in the cavity 601, be connected with one on the piston 604 and drive piston 604 is done linear reciprocating motion in described cavity 601 straight line conveyer structure 605, straight line conveyer structure 605 is linear electric motors or cylinder or electric pushrod, is generally linear electric motors, and movable in the cavity of pump case 602 for the ease of piston 604, can lubricant grease be set at piston 604, can also increase sealing like this, piston 604 is drawn back, so that cavity 601 produces vacuum, liquid adsorption can be come in, certainly can also be other can be with in the liquid suction pump and then the pump of discharging.
Stuck-module 4 is positioned at the place ahead of mobile detection module 2, when mobile detection module 2 moves forward, can insert its inside with calibration solution capillary mozzle 205 with being detected liquid and waste liquid capillary mozzle 203, stuck-module 4 comprises two detected liquid line enclosed elastic modules 401, a detected liquid connector 402 that can be connected with detected liquid and waste liquid capillary mozzle 203 and a calibration solution passage 403 that is communicated with described calibration liquid pool 5, when the free open end of detected liquid and waste liquid capillary mozzle 203 is in two detected liquid line enclosed elastic modules 401 in one of them the time, it is closed, two detected liquid line enclosed elastic modules 401 one in front and one in back arrange, wherein, before that is away from detected liquid and waste liquid capillary mozzle 203, between two detected liquid line enclosed elastic modules 401 fluid passage 404 that is communicated with waste liquid pool 7 is arranged, because in the present embodiment, calibration liquid pool 5, waste liquid pool 7 is two cavity volumes that are arranged in the base, so calibration liquid pool 5, waste liquid pool 7 can pass through fabrication hole or pipeline and calibration solution passage, fluid passage is communicated with, and detected liquid connector 402 is arranged in the place ahead of forward that of two detected liquid line enclosed elastic modules 401; So that be connected with the container of the detected liquid in outside, the front end of calibration solution passage 403 is provided with the calibration tube enclosed elastic module 405 that is closed when calibration solution capillary mozzle 205 is in wherein.And detected liquid line enclosed elastic module 401 comprises two the first elastomer block 401a that made by resilient material, and resilient material can be elastic caoutchouc or elastoplast or polyurethane.Two adjacent sides of described two the first elastomer block 401a fit, form the seam of fitting, described detected liquid and waste liquid capillary mozzle 203 are aimed in the centre position of described applying seam, the bearing of trend of applying seam is identical with waste liquid capillary mozzle 203 working direction with detected liquid, when described detected liquid and waste liquid capillary mozzle 203 inserts between described two the first elastomer block 401a, the contraction that is squeezed of two adjacent applying sides of described two the first elastomer block 401a and described detected liquid and waste liquid capillary mozzle 203 contacted parts.Because the first elastomer block 401a is that resilient material is made, two the first elastomer block 401a are fixed simultaneously, so when detected liquid and waste liquid capillary mozzle 203 inserts between two the first elastomer block 401a, the side extruding of two the first elastomer block 401a can be made it to shrink, simultaneously not with two the first elastomer block 401a between the time lateral parts that contact continue applying, so that be in sealed state between two the first elastomer block 401a the time, to be detected liquid and waste liquid capillary mozzle 203 seals up, in order to obtain better sealing effectiveness, can Seal Oil or seal grease be set in the side that two the first elastomer block 401a fit, to strengthen sealing effectiveness, and fluid passage 404 two ends that are communicated with waste liquid pool 7 are all sealed up by two the first elastomer block 401a, so that in detected liquid and 203 insertions of waste liquid capillary mozzle, it just is communicated with waste liquid pool 7.Simultaneously, also comprise two O type circles 406 that can be passed by described detected liquid and waste liquid capillary mozzle 203, the internal diameter of two O type circles 406 is less than the external diameter of detected liquid and waste liquid capillary mozzle 203, two O type circles 406 are separately positioned on the rear of two detected liquid line enclosed elastic modules 401 and fit with it, one of them O type circle 406 is positioned at fluid passage 404, and fit to increase sealing to fluid passage with the trailing flank of two the first elastomer block 401a that consist of detected liquid line enclosed elastic module 401, these two O type circles 406 can also be wiped the residual liquid that is detected liquid and waste liquid capillary mozzle 203 outer walls in addition, avoid cross pollution, general, the internal diameter of an O type circle 406 is described detected liquid and waste liquid capillary mozzle 203 external diameters 0.75-0.95 times.Calibration tube enclosed elastic module 405 comprises the elastic body 405a that is made by two resilient materials, resilient material is generally elastic caoutchouc or elastoplast or polyurethane, elastic body 405a is fixed and can not moves, two adjacent sides of two elastic body 405a fit, form the seam of fitting, the bearing of trend of applying seam is identical with calibration solution capillary mozzle 205 working direction, described calibration solution capillary mozzle 205 is aimed in the centre position of described applying seam, when described calibration solution capillary mozzle 205 inserts between described two elastic body 405a, the contraction that is squeezed of two adjacent applying sides of described two elastic body 405a and described calibration solution capillary mozzle 205 contacted parts, this part contraction is the contraction of resilient material itself, the part of contact does not continue to fit, calibration solution capillary mozzle 205 is sealed up, be provided with one in the described calibration solution passage 403 and can be calibrated the O RunddichtringO 407 that liquid capillary mozzle passes, the opening that is communicated with described calibration liquid pool 5 of described calibration solution passage 403 is between described O RunddichtringO 407 and two elastic body 405a, general, the internal diameter of O RunddichtringO 407 is 0.75-0.95 times of described calibration solution capillary mozzle external diameter, like this when calibration solution capillary mozzle 205 passes O RunddichtringO 407 and enters calibration solution passage 403, whole calibration solution passage 403 is sealed, be not communicated with the outside, only be communicated with calibration liquid pool 5, be convenient to calibration solution capillary mozzle 205 and draw calibration solution, O RunddichtringO 407 can also be wiped the liquid of calibration solution capillary mozzle 205 outer walls simultaneously, avoids cross pollution.
For those two elastic body 405a of increasing in the place ahead and the sealing between the calibration solution passage 403, the rear end of described two elastic body 405a is provided with the front O RunddichtringO 411 of fitting with it and can be passed by described calibration solution capillary mozzle 205; The internal diameter of described front O RunddichtringO 411 is 0.75-0.95 times of described calibration solution capillary mozzle 205 external diameters, and simultaneously, front O RunddichtringO 411 can also be wiped the liquid of calibration solution capillary mozzle 205 outer walls, avoids cross pollution.
Insert the applying seam of two elastic body 405a for the ease of calibration solution capillary mozzle, the rear end of the applying seam of two elastic body 405a is provided with pre-small post-large guiding structure 405b, in the present embodiment, the opening that guiding structure 405b narrows down forward gradually for the rear end from the seam of fitting.Same, insert for the ease of detected liquid and waste liquid capillary mozzle 203; Rear end at described two elastomer block 401a applying seam is provided with pre-small post-large guiding structure 401b, the opening that guiding structure 401b narrows down forward gradually for the rear end from the seam of fitting.
The detection method of measurement module repeatedly comprises following steps:
A) calibration solution calibration; Utilize the linear conveying device 3 in the portable instrumentation to move forward at described base 1 with described mobile detection module 2, so that arriving the precalculated position, described mobile detection module 2 is communicated with calibration liquid pool 5, the calibration solution that utilizes micropump 6 to draw in the calibration liquid pool 5 enters mobile detection module 2, in entering micropump 6, and then with the discharge of the calibration solution in the micropump 6, enter waste liquid pool 7, in the calibration solution discharge process, the calibration solution of discharging from micropump 6 is full of whole measuring cell 202 and fluid passage 404, after detecting sensor 8 detections, the result that detecting sensor 8 will detect issues the signal processing unit of portable instrumentation with the form of electric signal; In the present embodiment, the precalculated position that mobile detection module arrives is exactly the calibration solution passage 403 that is communicated with calibration liquid pool 5, the free open end of the calibration solution capillary mozzle 205 of mobile detection module enters in the calibration solution passage 403, is communicated with calibration liquid pool 5 by calibration solution passage 403; At this moment, detected liquid and waste liquid capillary mozzle 203 are positioned at detected liquid line enclosed elastic module 401, be sealed, because the micropump 6 that adopts is piston pump, so will calibrate first in the calibration solution sucker pump in the liquid pool 5 by piston pump, then linear electric motors continue to move forward with the movable block 201 of described mobile detection module, so that detected liquid and waste liquid capillary mozzle 203 are communicated with by fluid passage 404 with waste liquid pool 7, at this moment, calibration solution capillary mozzle 205 detected liquid line enclosed elastic modules 405 seal up, liquid can not be from this capillary mozzle out, then piston pump is started working, and calibration solution is discharged in the pump enter waste liquid pool 7 measuring cell 5 is full of calibration solution;
B) detected liquid detecting; After finishing the calibration liquid detecting, linear conveying device 3 continues with mobile detection module 2 front movements, so that described mobile detection module 2 arrives precalculated position and detected fluid connection, in this process, calibration solution capillary mozzle 205 always detected liquid line enclosed elastic module 405 seals up, this locates described precalculated position, it is exactly the position that detected liquid and waste liquid capillary mozzle 203 are communicated with detected liquid connector 402, piston pump on the mobile detection module 2 is started working at this moment, extract the measuring cell 5 that detected liquid enters mobile detection module 2, after detecting sensor 8 detections, the result that detecting sensor 8 will detect issues the signal processing unit of portable instrumentation with the form of electric signal, then, linear conveying device 3 is with mobile detection module 2 rear movements, so that detected liquid and waste liquid capillary mozzle 203 are positioned at fluid passage 404, is communicated with waste liquid pool 7, piston pump enters waste liquid pool 7 with the liquid after being detected in the pump.General, completing steps a) with step b) after, also comprise step c); Flushing and secondary calibration; Described mobile detection module 2 is under the drive of linear conveying device, arriving the precalculated position described in the described step a) is communicated with calibration liquid pool 5, at this moment, detected liquid and waste liquid capillary mozzle 203 are closed, the free open end of calibration solution capillary mozzle 205 enters in the calibration solution passage 403, is communicated with calibration liquid pool 5 by calibration solution passage 403; Calibrate from calibration liquid pool 5 interior sucking-off calibration solutions, then the calibration solution after will detecting enters waste liquid pool 7, realization is to the flushing of mobile detection module 2 with to the secondary calibration of detecting sensor 8, micropump enters mobile detection module 2 from calibration liquid pool 5 interior suction calibration solutions, then micropump is discharged calibration solution again, through measuring cell, and it is full of, twice action so that calibration solution can wash measuring cell, for measurement next time is prepared, simultaneously, detecting sensor 8 also can be measured calibration solution, obtains calibrating signal.
In above-mentioned measuring process, the measurement possibility interval of twice detected liquid for a long time, the during this time sensitivity of the detecting sensor in the measuring cell may be drifted about, so can be set in regular time, the operation of execution primary calibration, calibration solution in measuring cell and the passage is upgraded once, keep the accuracy of detecting sensor.
It is about V1/V2=4 that the suction calibration solution of step a) and two steps of step b) and the volume ratio of detected liquid close, namely the amount of the detected liquid of sampling be the filling liquid passage the calibration solution total amount about 1/4th.This relation has the clean enough calibration solution that whole passage is cleaned to state to be measured after satisfying each the measurement, and is ready for measure next time, exceeds again waste reagent simultaneously; In step a, can be as required, the detection that repeats calibration solution repeatedly, to wash away in the measuring cell and the detected liquid residue in detected liquid and the waste liquid capillary mozzle, guarantee the accuracy of measurement result, the process that this repeated detection is calibrated can by program arrange realize, can avoid interference, obtain the most accurately calibration result.Portable instrumentation compares two testing results in step a) and the step b), and then the detected liquid characteristic index of judgement, so-called characteristic index refers to detect the result who obtains after the contrast, this result can be the result of Data Comparison, also can be the result of curve comparison, if detection blood sugar, after then the detection numerical value that obtains of step a) and step b) compares, just know that blood sugar is high or low, if what detect is whether a kind of liquid is contaminated by heavy metals, after the detection numerical value/curve that obtains after then the detection of step a) and step b) is finished compares, just know heavy metal such as iron in the liquid, whether chromium etc. have surpassed national examination criteria, if what detect is the turbidity of tap water, after the testing result that obtains after then the detection of step a) and step b) is finished compares, can know all whether the turbidity of tap water has exceeded standard.
In the present embodiment, mobile detection module 2 comprises movable block 201, movable block is connected with linear conveying device 3, be provided with measuring cell 202 in the described movable block 201, described detecting sensor 8 for detection of described measuring cell 202 interior liquid is arranged in the described measuring cell 202, described movable block 201 is provided with calibration solution and the detected liquid capillary mozzle 206 that is communicated with described measuring cell 202, calibration solution and detected liquid capillary mozzle 206 are hard capillary mozzle, are made by stainless steel or plastics.
And waste liquid pool 7 is communicated with the outlet of micropump 6, and the import of micropump then is communicated with measuring cell 202.Micropump is ram pump or vane pump or other known pumps with import and outlet such as centrifugal pump or peristaltic pump, what present embodiment adopted is peristaltic pump, the peristaltic pump import is communicated with by the first flexible pipe 204 with measuring cell 202, outlet is passed through soft pipe connection with waste liquid pool, and peristaltic pump is arranged in the portable instrumentation.In the present embodiment, only have a calibration solution and detected liquid capillary mozzle 206, rather than two, calibration liquid and detected liquid all are to enter measuring cell 5 by this calibration solution and detected liquid capillary mozzle 206, are detected by detecting sensor 8.
In the present embodiment, described stuck-module 4 is positioned at the place ahead of described mobile detection module 2, it comprises two enclosed elastic modules 408, when the free open end of described calibration solution and detected liquid capillary mozzle 206 was in one of them inside, calibration solution and detected liquid capillary mozzle 206 were closed; Stuck-module 4 also comprises detected liquid connector 402 and a passage 409 that is communicated with described calibration liquid pool 5 that can be connected with described calibration solution and detected liquid capillary mozzle 206, passage 409 is between described two enclosed elastic modules 408, sealed up by two enclosed elastic modules 408, only communicate with calibration liquid pool 5, detected liquid connector 402 is arranged in the place ahead of forward that of described two enclosed elastic modules 408.Described enclosed elastic module 408 comprises two the second elastomer block 408a that made by resilient material, general employing elastic caoutchouc or elastoplast or polyurethane, two adjacent sides of described two the second elastomer block 408a fit, form the seam of fitting, the bearing of trend of applying seam is identical with detected liquid capillary mozzle 206 working direction with calibration solution, described calibration solution and detected liquid capillary mozzle 206 are aimed in the centre position of described applying seam, be convenient to calibration solution and 206 insertions of detected liquid capillary mozzle, when described calibration solution and detected liquid capillary mozzle 206 inserts between described two the second elastomer block 408a, the contraction that is squeezed of two adjacent applying sides of described two the second elastomer block 408a and described calibration solution and detected liquid capillary mozzle 206 contacted parts, this part contraction is the contraction of resilient material itself, the part of contact does not continue to fit, calibration solution and detected liquid capillary mozzle 206 are sealed up, stuck-module 4 also comprises two O type circles 410 that can be passed by described calibration solution and detected liquid capillary mozzle 206, described two O type circles 410 are separately positioned on the rear of described two enclosed elastic modules 408 and fit with it, match with two enclosed elastic modules 408, can better seal passage, these two O type circles can also be wiped the liquid of calibration solution and detected liquid capillary mozzle 206 outer walls simultaneously, avoid cross pollution, described two O type circle 410 internal diameters are less than the external diameter of described calibration solution and detected liquid capillary mozzle 206.General, the internal diameter of described O type circle 410 is described calibration solution and detected liquid capillary mozzle 206 external diameters 0.75-0.95 times.
The insertion for be more convenient for calibration solution and detected liquid capillary mozzle 206 equally, the rear end of described two the second elastomer block 408a applying seam is provided with pre-small post-large guiding structure 408b, the opening that guiding structure 408b narrows down forward gradually for the rear end from the seam of fitting.
Can find out from said structure, than embodiment 1, the structure of present embodiment is simpler, is easy to make, and volume is less, is more convenient for carrying and installing, and the parts of employing also tail off, and cost is lower.Below, according to the structure of present embodiment measurement module, lower its using method of summary,
A) calibration solution calibration; Linear conveying device 3 moves forward at described base 1 with described mobile detection module 2, so that arriving the precalculated position, described mobile detection module 2 is communicated with calibration liquid pool 5, the calibration solution that utilizes micropump 6 to draw in the calibration liquid pool 5 enters mobile detection module 2, after detecting sensor 8 detections, the result that detecting sensor 8 will detect issues the signal processing unit of portable instrumentation with the form of electric signal, the calibration solution after the detection enters waste liquid pool 7; In the present embodiment, the precalculated position that mobile detection module 2 arrives is exactly the passage 409 that is communicated with calibration liquid pool 5, and the free open end of the calibration solution of mobile detection module 2 and detected liquid capillary mozzle 206 is communicated with calibration liquid pool 5 by passage 409; Because the micropump that present embodiment adopts is peristaltic pump, the wriggling delivery side of pump is communicated with waste liquid pool 7, when the movable block 201 of linear electric motors with mobile detection module 2 moves forward, so that calibration solution and detected liquid capillary mozzle 206 free open ends are when being positioned at passage 409, peristaltic pump rotates, with the calibration solution in the calibration liquid pool 5 by in calibration solution and detected liquid capillary mozzle 206 suction pumps, in the process in entering pump, calibration solution is through measuring cell 202, detect by the detecting sensor 8 in the measuring cell 202, obtain testing result, then the calibration solution after being detected enters waste liquid pool 7 by the wriggling delivery side of pump, and whole detection action is very simple, fast; After detection is finished calibration solution and is finished calibration; Begin to detect detected liquid;
B) detected liquid detecting; Linear conveying device 3 continues to move forward with described mobile detection module 2, so that described mobile detection module 2 arrives precalculated position and detected fluid connection, micropump 6 is started working and is drawn detected liquid and enter mobile detection module 2, after detecting sensor 8 detections, the result that detecting sensor 8 will detect issues the signal processing unit of portable instrumentation with the form of electric signal, the detected liquid after the detection enters waste liquid pool 7; This locates described precalculated position, it is exactly the position that calibration solution and detected liquid capillary mozzle 206 are communicated with detected liquid connector 402, this moment, peristaltic pump was started working, draw the measuring cell 202 that detected liquid enters mobile detection module 2, after detecting sensor 8 detections, the result that detecting sensor 8 will detect issues the signal processing unit of portable instrumentation with the form of electric signal, simultaneously, detected liquid enters waste liquid pool 7 by the wriggling delivery side of pump, finishes the action of discharging waste liquid.
General, completing steps a) with step b) after, also comprise step c); Flushing and secondary calibration; Described mobile detection module 2 is under the drive of linear conveying device, arriving the precalculated position described in the described step a) is communicated with calibration liquid pool 5, at this moment, in the free open end admission passage 409 of calibration solution and detected liquid capillary mozzle 206, be communicated with calibration liquid pool 5 by passage 409; Enter in the measuring cell 202 of mobile detection module 2 from calibration liquid pool 5 interior suction calibration solutions, measuring cell 202 is washed, remove residual detected liquid, 8 pairs of calibration solutions of detecting sensor detect simultaneously, realization is to the flushing of mobile detection module 2 with to the secondary calibration of detecting sensor 8, for measurement next time is prepared.
In above-mentioned measuring process, the measurement possibility interval of twice detected liquid for a long time, the during this time sensitivity of the detecting sensor 8 in the measuring cell 202 may be drifted about, so can be set in regular time, the operation of execution primary calibration, calibration solution in measuring cell 202 and the passage 409 is upgraded once, keep the accuracy of detecting sensor.
Portable instrumentation compares two testing results in step a) and the step b), and then judges detected liquid characteristic index; So-called characteristic index refers to detect the result who obtains after the contrast, this result can be the result of Data Comparison, also can be the result of curve comparison, if detection blood sugar, after then the detection numerical value that obtains of step a) and step b) compares, just know that blood sugar is high or low, if what detect is whether a kind of liquid is contaminated by heavy metals, after the detection numerical value/curve that obtains after then the detection of step a) and step b) is finished compares, just know heavy metal such as iron in the liquid, whether chromium etc. have surpassed national examination criteria, if what detect is the turbidity of tap water, after the testing result that obtains after then the detection of step a) and step b) is finished compares, can know all whether the turbidity of tap water has exceeded standard.
Can find out from above-mentioned testing process, the detection method of present embodiment, very rapid, the action in the testing process is also few, quicker.
Claims (30)
1. the self calibration of portable instrumentation measurement module repeatedly is characterized in that:
Comprise a base (1);
One is arranged on the stuck-module (4) on the described base (1);
The one mobile detection module (2) with detecting sensor (8) for detection of calibration solution and detected liquid;
The one calibration liquid pool (5) that can deposit the calibration solution of enough volumes and be communicated with described stuck-module (4) and can be communicated with described mobile detection module (2) when being positioned at the precalculated position at described mobile detection module (2);
One is used for depositing calibration solution after the detection and the waste liquid pool (7) of detected liquid;
Described mobile detection module (2) comprises movable block (201), be provided with measuring cell (202) in the described movable block (201), detecting sensor (8) for detection of the interior liquid of measuring cell (202) is arranged in the described measuring cell (202), and described movable block (201) is provided with the detected liquid that is communicated with described measuring cell (202) and waste liquid capillary mozzle (203), calibration solution capillary mozzle (205).
2. the self calibration of portable instrumentation according to claim 1 measurement module repeatedly, it is characterized in that: described stuck-module (4) is positioned at the place ahead of described mobile detection module (2), it comprises two detected liquid line enclosed elastic modules (401), when described detected liquid and waste liquid capillary mozzle (203) free open end are in one of them when inner, described detected liquid and waste liquid capillary mozzle (203) are closed; Described stuck-module (4) also comprises a detected liquid connector (402) that can be connected with described detected liquid and waste liquid capillary mozzle (203) and a calibration solution passage (403) that is communicated with described calibration liquid pool (5); The fluid passage (404) that is communicated with described waste liquid pool (7) is arranged between described two detected liquid line enclosed elastic modules (401); Described detected liquid connector (402) is arranged in the place ahead of forward that of described two detected liquid line enclosed elastic modules (401); The place ahead of described calibration solution passage (403) is provided with calibration tube enclosed elastic module (405), and when described calibration solution capillary mozzle (205) free open end was in wherein, described calibration solution capillary mozzle (205) was closed.
3. the self calibration of portable instrumentation according to claim 2 measurement module repeatedly, it is characterized in that: described detected liquid line enclosed elastic module (401) comprises two the first elastomer block (401a) of being made by resilient material, two adjacent sides of described two the first elastomer block (401a) fit, form the seam of fitting, described detected liquid and waste liquid capillary mozzle (203) are aimed in the centre position of described applying seam.
4. the self calibration of portable instrumentation according to claim 3 measurement module repeatedly is characterized in that: the fit rear end of seam of described two the first elastomer block (401a) is provided with pre-small post-large the first guiding structure (401b).
5. the self calibration of portable instrumentation according to claim 3 measurement module repeatedly, it is characterized in that: described stuck-module (4) also comprises two O type circles (406) that can be passed by described detected liquid and waste liquid capillary mozzle (203), the internal diameter of described two O type circles (406) is less than the external diameter of described detected liquid and waste liquid capillary mozzle (203), the internal diameter of described two O type circles (406) is less than the external diameter of described detected liquid and waste liquid capillary mozzle (203), and described two O type circles (406) are separately positioned on the rear of described two detected liquid line enclosed elastic modules (401) and fit with it.
6. the self calibration of portable instrumentation according to claim 5 measurement module repeatedly is characterized in that: the internal diameter of a described O type circle (406) be described detected liquid and waste liquid capillary mozzle (203) external diameter 0.75-0.95 doubly.
7. the self calibration of portable instrumentation according to claim 3 measurement module repeatedly is characterized in that: described the first elastomer block (401a) is made by elastic caoutchouc or elastoplast or polyurethane.
8. according to claim 2 or the self calibration of 4 or 5 or 6 or 7 described portable instrumentations measurement module repeatedly, it is characterized in that: described calibration tube enclosed elastic module (405) comprises two elastic bodys of being made by resilient material (405a), two adjacent sides of described two elastic bodys (405a) fit, form the seam of fitting, described calibration solution capillary mozzle (205) is aimed in the centre position of described applying seam, be provided with an O RunddichtringO (407) that can be passed by described calibration solution capillary mozzle (205) in the described calibration solution passage (403), the opening that is communicated with described calibration liquid pool (5) of described calibration solution passage (403) is positioned between described O RunddichtringO (407) and described two elastic bodys (405a).
9. the self calibration of portable instrumentation according to claim 8 measurement module repeatedly is characterized in that: be provided with the front O RunddichtringO (411) of fitting with it and can be passed by described calibration solution capillary mozzle (205) in the rear end of described two elastic bodys (405a); The internal diameter of described front O RunddichtringO (411) is 0.75-0.95 times of described calibration solution capillary mozzle (205) external diameter.
10. the self calibration of portable instrumentation according to claim 8 measurement module repeatedly is characterized in that: be provided with pre-small post-large guiding structure (405b) in the fit rear end of seam of described two elastic bodys (405a).
11. the self calibration of portable instrumentation according to claim 8 is measurement module repeatedly, it is characterized in that: the internal diameter of described O RunddichtringO (407) is 0.75-0.95 times of described calibration solution capillary mozzle (205) external diameter.
12. the self calibration of portable instrumentation according to claim 8 is measurement module repeatedly, it is characterized in that: described elastic body (405a) is made by elastic caoutchouc or elastoplast or polyurethane.
13. the self calibration of portable instrumentation according to claim 2 is measurement module repeatedly, it is characterized in that: described detected liquid and waste liquid capillary mozzle (203), calibration solution capillary mozzle (205) are made by stainless steel or plastics.
14. the self calibration of portable instrumentation according to claim 1 is measurement module repeatedly, it is characterized in that: described calibration liquid pool (5) and described waste liquid pool (7) are for being arranged on two cavity volumes bottom the base (1) or being arranged on two containers on the base.
15. the self calibration of portable instrumentation according to claim 1 is measurement module repeatedly, it is characterized in that: described base (1) is provided with a case (9).
16. the self calibration of portable instrumentation is measurement module repeatedly, it is characterized in that:
Comprise a base (1);
One is arranged on the stuck-module (4) on the described base (1);
The one mobile detection module (2) with detecting sensor (8) for detection of calibration solution and detected liquid;
The one calibration liquid pool (5) that can deposit the calibration solution of enough volumes and be communicated with described stuck-module (4) and can be communicated with described mobile detection module (2) when being positioned at the precalculated position at described mobile detection module (2);
One is used for depositing calibration solution after the detection and the waste liquid pool (7) of detected liquid;
Described mobile detection module (2) comprises movable block (201), be provided with measuring cell (202) in the described movable block (201), described detecting sensor (8) for detection of the interior liquid of described measuring cell (202) is arranged in the described measuring cell (202), and described movable block (201) is provided with calibration solution and the detected liquid capillary mozzle (206) that is communicated with described measuring cell (202).
17. the self calibration of portable instrumentation according to claim 16 is measurement module repeatedly, it is characterized in that: described stuck-module (4) is positioned at the place ahead of described mobile detection module (2), it comprises two enclosed elastic modules (408), when the free open end of described calibration solution and detected liquid capillary mozzle (206) was in one of them inside, described calibration solution and detected liquid capillary mozzle (206) were closed; Described stuck-module (4) also comprises a detected liquid connector (402) that can be connected with described calibration solution and detected liquid capillary mozzle (206) and a passage (409) that is communicated with described calibration liquid pool (5), described passage (409) is positioned between described two enclosed elastic modules (408), and described detected liquid connector (402) is arranged in the place ahead of forward that of described two enclosed elastic modules (408).
18. the self calibration of portable instrumentation according to claim 17 is measurement module repeatedly, it is characterized in that: described enclosed elastic module (408) comprises two the second elastomer block (408a) of being made by resilient material, two adjacent sides of described two the second elastomer block (408a) fit, form the seam of fitting, described calibration solution and detected liquid capillary mozzle (206) are aimed in the centre position of described applying seam.
19. the self calibration of portable instrumentation according to claim 18 is measurement module repeatedly, it is characterized in that: the rear end of described two the second elastomer block (408a) applying seam is provided with pre-small post-large the second guiding structure (408b).
20. according to claim 17 or the self calibration of 18 or 19 described portable instrumentations measurement module repeatedly, it is characterized in that: described stuck-module (4) also comprises two O type circles (410) that can be passed by described calibration solution and detected liquid capillary mozzle (206), described two O type circles (410) are separately positioned on the rear of described two enclosed elastic modules (408) and fit with it, and described two O type circles (410) internal diameter is less than the external diameter of described calibration solution and detected liquid capillary mozzle (206).
21. the self calibration of portable instrumentation according to claim 20 is measurement module repeatedly, it is characterized in that: the internal diameter of described O type circle (410) is described calibration solution and detected liquid capillary mozzle (206) external diameter 0.75-0.95 times.
22. the self calibration of portable instrumentation according to claim 18 is measurement module repeatedly, it is characterized in that: described the second elastomer block (408a) is made by elastic caoutchouc or elastoplast or polyurethane.
23. the self calibration of portable instrumentation according to claim 16 is measurement module repeatedly, it is characterized in that: described calibration solution and detected liquid capillary mozzle (206) are made by stainless steel or plastics.
24. the self calibration of portable instrumentation according to claim 16 is measurement module repeatedly, it is characterized in that: described calibration liquid pool (5) and described waste liquid pool (7) are for being arranged on two cavity volumes bottom the base (1) or being arranged on two containers on the base.
25. the self calibration of portable instrumentation according to claim 16 is measurement module repeatedly, it is characterized in that: described base (1) is provided with a case (9).
26. a portable instrumentation is characterized in that: described portable instrumentation comprises repeatedly measurement module of the described self calibration of claim 1-25 any one.
27. the self calibration of a portable instrumentation as claimed in claim 1 is the using method of measurement module repeatedly, it is characterized in that comprising following steps:
A) calibration solution calibration; Described mobile detection module (2) arrives the precalculated position and is communicated with calibration liquid pool (5), the suction calibration solution enters mobile detection module (2) in the liquid pool from calibrating, then calibration solution is entered waste liquid pool (7), be discharged in the process of waste liquid pool (7) at calibration solution, calibration solution detects through detecting sensor (8), and the result that detecting sensor (8) will detect issues the signal processing unit of portable instrumentation with the form of electric signal;
B) detected liquid detecting; Described mobile detection module (2) arrives precalculated position and detected fluid connection, suck detected liquid and enter mobile detection module (2), after detecting sensor (8) detection, the result that detecting sensor (8) will detect issues the signal processing unit of portable instrumentation with the form of electric signal, the detected liquid after then will detecting enters waste liquid pool (7).
28. the self calibration of a kind of portable instrumentation according to claim 27 is the using method of measurement module repeatedly, it is characterized in that: the flushing and the secondary calibration that also comprise step c); The described precalculated position that described mobile detection module (2) arrives in the described step a) is communicated with calibration liquid pool (5), the suction calibration solution enters mobile detection module (2) in the liquid pool from calibrating, then the calibration solution after will detecting enters waste liquid pool (7), realizes to the flushing of mobile detection module (2) with to the secondary calibration of detecting sensor (8).
29. the self calibration of a portable instrumentation as claimed in claim 16 is the using method of measurement module repeatedly, it is characterized in that comprising following steps:
A) calibration solution calibration; Described mobile detection module (2) arrives the precalculated position and is communicated with calibration liquid pool (5), the suction calibration solution enters mobile detection module (2) in the liquid pool from calibrating, after detecting sensor (8) detection, the result that detecting sensor (8) will detect issues the signal processing unit of portable instrumentation with the form of electric signal, the calibration solution after then will detecting enters waste liquid pool (7);
B) detected liquid detecting; Described mobile detection module (2) arrives precalculated position and detected fluid connection, suck detected liquid and enter mobile detection module (2), after detecting sensor (8) detection, the result that detecting sensor (8) will detect issues the signal processing unit of portable instrumentation with the form of electric signal, the detected liquid after then will detecting enters waste liquid pool (7).
30. the self calibration of a kind of portable instrumentation according to claim 29 is the using method of measurement module repeatedly, it is characterized in that: the flushing and the secondary calibration that also comprise step c); Described mobile detection module (2) arrives the precalculated position described in the described step a) and is communicated with calibration liquid pool (5), the suction calibration solution enters mobile detection module (2) in the liquid pool from calibrating, then the calibration solution after will detecting enters waste liquid pool (7), realizes to the flushing of mobile detection module (2) with to the secondary calibration of detecting sensor (8).
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| CN 201210017394 CN102565436B (en) | 2012-01-19 | 2012-01-19 | Self-calibration multi-measurement module of portable detecting instrument, and using method thereof |
| PCT/CN2012/084712 WO2013107207A1 (en) | 2012-01-19 | 2012-11-16 | Self-calibration multi-measurement module for portable detection instrument and use method therefor |
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| CN 201210017394 CN102565436B (en) | 2012-01-19 | 2012-01-19 | Self-calibration multi-measurement module of portable detecting instrument, and using method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102565436B (en) * | 2012-01-19 | 2013-09-18 | 湖州凯立特医疗器械有限公司 | Self-calibration multi-measurement module of portable detecting instrument, and using method thereof |
| CN103743917B (en) * | 2013-12-25 | 2015-09-16 | 浙江凯立特医疗器械有限公司 | Self-calibrating measuring device and portable instrumentation |
| DE202015101756U1 (en) * | 2015-04-10 | 2016-07-13 | Bürkert Werke GmbH | calibration System |
| CN108226458A (en) * | 2018-02-02 | 2018-06-29 | 董寿岳 | A kind of division of endocrinology's urine sugar detection device |
| CN115656188B (en) * | 2022-12-12 | 2023-04-11 | 北京国光领航科技有限公司 | Self-calibration laser therapeutic instrument |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1416529A (en) * | 2000-01-05 | 2003-05-07 | Abt先进生物分析技术有限责任公司 | Mobile hand-held unit comprising reusable biosensor |
| EP1333288A2 (en) * | 1995-07-13 | 2003-08-06 | Bayer Corporation | Method of verifying tip placement in an aspirate and dispense system |
| CN101349672A (en) * | 2008-09-12 | 2009-01-21 | 福州大学 | Microflow control chip electrochemical detection device capable of accurately controlling electrode distance |
| CN202494684U (en) * | 2012-01-19 | 2012-10-17 | 湖州凯立特医疗器械有限公司 | Self-calibration multiple measuring module of portable detecting device |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3960497A (en) * | 1975-08-19 | 1976-06-01 | Beckman Instruments, Inc. | Chemical analyzer with automatic calibration |
| DE102005034574A1 (en) * | 2005-01-07 | 2006-07-20 | Merck Patent Gmbh | Method and device for taking and analyzing samples |
| JP2010501842A (en) * | 2005-08-24 | 2010-01-21 | テレケミストリー オサケユキチュア | Liquid sample test method, test apparatus, and multiple test apparatus automation system |
| US8236257B2 (en) * | 2006-04-26 | 2012-08-07 | Nikkiso Co., Ltd. | Biological component-measuring device and method for calibrating the same |
| FR2901360A1 (en) * | 2006-05-16 | 2007-11-23 | Horiba Abx Sas Soc Par Actions | PACKAGING DEVICE FOR BIOLOGICAL ANALYSIS |
| WO2010044126A1 (en) * | 2008-10-16 | 2010-04-22 | 株式会社島津製作所 | Sample injection port, and auto-sampler having the port |
| DE102009029305A1 (en) * | 2009-09-09 | 2011-03-10 | Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG | Analyzer for the automated determination of a measured variable of a liquid sample |
| JP2011196790A (en) * | 2010-03-18 | 2011-10-06 | Sysmex Corp | Apparatus for analyzing biological component and calibration cartridge |
| CN202404052U (en) * | 2011-11-30 | 2012-08-29 | 湖州凯立特医疗器械有限公司 | Liquid detection chip |
| CN102435635B (en) * | 2011-11-30 | 2013-11-13 | 湖州凯立特医疗器械有限公司 | Liquid detection chip and liquid detection method |
| CN102565436B (en) * | 2012-01-19 | 2013-09-18 | 湖州凯立特医疗器械有限公司 | Self-calibration multi-measurement module of portable detecting instrument, and using method thereof |
-
2012
- 2012-01-19 CN CN 201210017394 patent/CN102565436B/en active Active
- 2012-11-16 WO PCT/CN2012/084712 patent/WO2013107207A1/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1333288A2 (en) * | 1995-07-13 | 2003-08-06 | Bayer Corporation | Method of verifying tip placement in an aspirate and dispense system |
| CN1416529A (en) * | 2000-01-05 | 2003-05-07 | Abt先进生物分析技术有限责任公司 | Mobile hand-held unit comprising reusable biosensor |
| CN101349672A (en) * | 2008-09-12 | 2009-01-21 | 福州大学 | Microflow control chip electrochemical detection device capable of accurately controlling electrode distance |
| CN202494684U (en) * | 2012-01-19 | 2012-10-17 | 湖州凯立特医疗器械有限公司 | Self-calibration multiple measuring module of portable detecting device |
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| CN102565436A (en) | 2012-07-11 |
| WO2013107207A1 (en) | 2013-07-25 |
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