CN102499634B - Living human eye retina dynamic imaging device with image stabilizing function and method - Google Patents
Living human eye retina dynamic imaging device with image stabilizing function and method Download PDFInfo
- Publication number
- CN102499634B CN102499634B CN201110328377.6A CN201110328377A CN102499634B CN 102499634 B CN102499634 B CN 102499634B CN 201110328377 A CN201110328377 A CN 201110328377A CN 102499634 B CN102499634 B CN 102499634B
- Authority
- CN
- China
- Prior art keywords
- unit
- human eye
- retina
- imaging
- line
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Landscapes
- Eye Examination Apparatus (AREA)
Abstract
The invention relates to a living human eye retina dynamic imaging device with the image stabilizing function and a method, wherein the imaging device comprises a living human eye retina dynamic imaging unit, a linear confocal unit, a correction unit, a light splitting unit, a signal conversion unit and a processor. The linear confocal unit scans fundus retina in a one-dimensional way to obtain a high frame frequency image, the processor operates the image to obtain the retina jittering volume and feeds back the control voltage of the correction unit for correcting the retina jittering to the correction unit, so the connection unit can real-timely correct the retina jittering of the living human eye retina dynamic imaging unit. The invention can simultaneously obtain the high frame frequency image of the fundus retina after the linear confocal one-dimensional scanning and a jittering-free high resolution fundus retina image which is obtained via the living human eye retina dynamic imaging unit, and has the advantages of accurate retina jittering measurement, high jittering correction precision, simple system structure, good real-time performance, good stability and the like.
Description
Technical field
The invention belongs to the bio-imaging technical field of Application Optics, for a kind of retina of the living human eye with steady picture function dynamic imaging device and method, can be widely used in biomedical ophthalmologic examination.
Background technology
At present, for the technology of living human eye retina image-forming, fundus camera, laser cofocus scanning eye-checking instrument, optical coherent chromatographic imaging etc. are arranged, they have all obtained good imaging resolution.But, due to the amphiblestroid physiological property of living human eye, retina vision sensitive cells is always in irregular dither state, this shake comprises the multi-frequency composition, greatly about the 10-100Hz left and right, current living human eye retina image-forming technology imaging frame frequency is mostly in the 30Hz left and right, imaging results not only has the interframe shake, also there is serious shake in frame, if can't proofread and correct the retina shake, can't carry out Quantitative Study to retina image-forming, greatly limit applying of these imaging techniques.
The people such as the Zhang Yudong of Photoelectric Technology Inst., Chinese Academy of Sciences have successfully developed dynamic imager of living human eye retina (patent publication No.: CN 101926640 A), this system successfully is applied to the surface imaging field by adaptive optical technique, adaptive optics energy real-time detection human eye aberration also passes through wave-front corrector real time correction aberration, eliminate the picture element disperse that human eye aberration causes, obtained the high-resolution imaging result.Its system schematic as shown in Figure 1, illuminator provides light radiation, and this light radiation is incided on retina along the first light path, thereby and be reflected and form imaging, this imaging spreads into imaging system along the second light path, and imaging system is carried out imaging to retina certain depth zone.System also comprises control device, control device produces modulation signal and synchronizing signal is controlled illuminator and imaging system, make illuminator send pulsed light according to modulation signal, and imaging system coordinates this pulsed light synchronously continuous imaging to be carried out in the experimenter optical fundus according to synchronizing signal, directly to gather, obtain living human eye retina real-time video or image sequence.This dynamic imager of living human eye retina, imaging effect is good, but still there is defect in himself: due to the mode of employing face illumination dough-making powder detection, non-jitter in frame, but because data volume is large, the image acquisition limited speed, the frame frequency speed of imaging is little, the interframe shake can't be eliminated, and this defect has inevitably limited its application, has particularly hindered it and has been directly used in the inspection of ophthalmic diseases.
Be directed to the retina interframe jitter problem that the surface imaging low frame rate causes, the people such as the Shi Guohua of Photoelectric Technology Inst., Chinese Academy of Sciences have proposed confocal system and the method (number of patent application: 201010595574.X and 201010595587.7) based on line sweep.The device schematic diagram that patent is announced as shown in Figures 2 and 3, the outgoing beam warp optical beam transformation device of LASER Light Source is transformed to the one dimension Line beam, by scanning galvanometer scanning illumination human eye optical fundus, the imaging line light beam Yan Yuan road gone out from fundus reflex is returned and is entered image-generating unit, and synchronously obtains the real time imaging on human eye optical fundus through data acquisition and signal.This line sweep confocal system adopts the one dimension line sweep to the optical fundus retina image-forming, compare and the confocal laser ophthalmoscope that adopts spot scan, only use a scanning galvanometer scanning line beam lighting optical fundus, imaging frame frequency is large, in the retina frame, shake greatly reduces, can extract the interframe shake by imaging results being carried out to computing, make the shake of correction retina become possibility.
Summary of the invention
Technology of the present invention is dealt with problems: overcome above-mentioned the deficiencies in the prior art part, a kind of retina of the living human eye with steady picture function dynamic imaging device and method are provided, can obtain the amphiblestroid high frame frequency in the confocal optical fundus of line, large view field imaging and the amphiblestroid small field of view in dynamic imager of living human eye retina optical fundus, non-jitter, high-resolution imaging simultaneously, the present invention have the retina jitter measurement accurately, the advantages such as the jitter correction precision is high, system structure is simple, real-time performance is good, good stability.
Technical scheme of the present invention: a kind of retina of the living human eye with steady picture function dynamic imaging device comprises: correcting unit, spectrophotometric unit, dynamic imager of living human eye retina unit, the confocal unit of line, signal conversion unit and datatron;
Correcting unit is connected with signal conversion unit, dynamic imager of living human eye retina unit and spectrophotometric unit, correcting unit consists of tilting mirror and 4f battery of lens, the control Control of Voltage tilting mirror that signal conversion unit is exported is modulated and is proofreaied and correct the retina shake the imaging beam of dynamic imager of living human eye retina unit output, and light splitting cell illumination human eye optical fundus is crossed in the imaging beam direct transmission after the 4f battery of lens be tilted after mirror is modulated;
Spectrophotometric unit is connected with correcting unit, the confocal unit of line and human eye, spectrophotometric unit is dichroic light splitting plain film or dichroic Amici prism, for the dynamic imager of living human eye retina illuminating bundle of correcting unit outgoing directly is transmitted to intelligent's eye, from the direct transmission of the dynamic imager of living human eye retina imaging beam of human eye retina's outgoing, arrive correcting unit; With will arrive human eye from the Line beam deflecting reflection of line confocal unit outgoing, arrive the confocal unit of line from the Line beam deflecting reflection of human eye retina's outgoing;
The dynamic imager of living human eye retina unit is connected with correcting unit, the dynamic imager of living human eye retina unit is dynamic imager of living human eye retina, for human eye retina's imaging, comprise illuminator, imaging system, control device and ADAPTIVE OPTICS SYSTEMS, transmit after the calibrated cells modulate of the outgoing beam of dynamic imager of living human eye retina unit;
The confocal unit of line is connected with spectrophotometric unit, datatron, the confocal unit of line is the confocal ophthalmoscope system of a kind of line sweep or a kind of confocal ophthalmoscope system of line sweep based on laser diffraction, for surveying human eye retina's shake, the confocal unit of line comprises Line beam generation module, spectral module, scan module, image-forming module and output module.The emergent ray light beam of the confocal unit of line arrives the human eye optical fundus through the spectrophotometric unit deflecting reflection, and the imaging line light beam gone out from fundus reflex is through the confocal unit of spectrophotometric unit deflecting reflection loop line detection imaging, and imaging results is exported to datatron for calculating the retina shake;
Datatron is connected with the confocal unit of line, signal conversion unit, the imaging results of the confocal unit of line is exported to datatron, datatron adopts algorithm to extract the retina shake from imaging results, and solution is counted as the discrete control voltage of proofreading and correct the retina shake, exports to signal conversion unit;
Signal conversion unit is connected with datatron, correcting unit, signal conversion unit consists of D/A switch device and high-voltage amplifier, the discrete control voltage that datatron resolves the correction retina shake obtained is converted into analog quantity through the D/A switch device, and analog quantity is controlled voltage and be transferred to correcting unit after high-voltage amplifier is amplified;
Described tilting mirror is for reflecting at a high speed tilting mirror;
Described datatron is analog control circuit or digital computer.
The living human eye retina dynamic imaging method of the steady picture of band function is characterized in that performing step is as follows:
Step 1, the emergent ray light beam of the confocal unit of line reaches the human eye retina through the spectrophotometric unit deflecting reflection, the imaging line light beam reflected from human eye is through the confocal unit of spectrophotometric unit deflecting reflection loop line, the confocal unit of line carries out detection imaging to the imaging line light beam, obtains human eye retina's high frame frequency imaging results;
Described step 1 comprises:
Step 13, the confocal unit of line is surveyed the imaging line light beam, obtains human eye retina's high frame frequency imaging results.
Described step 2 comprises:
Described step 24 comprises:
Step 241, proofread and correct the control voltage of retina shake through the conversion of D/A switch device, by digital quantity, is converted to analog quantity;
Step 242, the control voltage of analog quantity, after high-voltage amplifier amplifies, transfers to correcting unit.
Described step 3 comprises:
Step 31, the outgoing beam of the dynamic imager of living human eye retina unit in real time modulation of calibrated unit and spectrophotometric unit successively directly is transmitted to intelligent's eyes retina;
Step 32, the imaging beam reflected from the human eye retina, after the direct transmission of spectrophotometric unit, goes back to the dynamic imager of living human eye retina unit through the correcting unit synchronous reflection;
Step 33, the dynamic imager of living human eye retina unit is surveyed the imaging beam of proofreading and correct through correcting unit, obtains the retina high-resolution imaging result of non-jitter.
Described step 31 comprises:
Step 311, after the modulation in real time of the calibrated unit of the outgoing beam of dynamic imager of living human eye retina unit, outgoing arrives spectrophotometric unit;
Step 312, the dynamic imager of living human eye retina unit direct transmission of outgoing beam of modulation in real time of calibrated unit is crossed spectrophotometric unit and is arrived the human eye retina.
Described step 32 comprises:
Step 321, the direct transmission of the imaging beam reflected from the human eye retina is crossed spectrophotometric unit and is arrived correcting unit;
Step 322, the calibrated units synchronization of the imaging beam directly transmitted from spectrophotometric unit is reflected back the dynamic imager of living human eye retina unit.
The present invention compares with existing living human eye retina image-forming technology, and following advantage is arranged:
(1) band of the present invention surely looks like living human eye retina dynamic imaging device and the method for function, and the confocal unit of line can access the amphiblestroid high frame frequency imaging in optical fundus.
(2) band of the present invention surely looks like living human eye retina dynamic imaging device and the method for function, extracts the retina shake from the line confocal imaging result of high frame frequency by algorithm, and the retina jitter measurement is accurate.
(3) band of the present invention surely looks like living human eye retina dynamic imaging device and the method for function, and retina jitter correction element adopts and reflects at a high speed the mirror that inclines, and correction accuracy is high, and real-time performance is good.
(4) band of the present invention surely looks like living human eye retina dynamic imaging device and the method for function, the dynamic imager of living human eye retina scanning element is by the shake of the confocal unit real-time detection of line retina, simultaneously by the shake of correcting unit real time correction retina, forming real-time closed-loop controls, the retina shake be can proofread and correct well, the amphiblestroid non-jitter in optical fundus, high-resolution imaging obtained.
(5) band of the present invention surely looks like living human eye retina dynamic imaging device and the method for function, only use a high speed to reflect tilting mirror and a 4f battery of lens formation correcting unit, have simple in structure, manufacture the advantage such as easy, good stability, be suitable for manufacturing and extensively promoting the use of in a large number.
The accompanying drawing explanation
Fig. 1 is the dynamic imager of living human eye retina schematic diagram;
Fig. 2 is the confocal Oph system and method structure chart of a kind of line sweep;
Fig. 3 is the confocal Oph system and method light path schematic diagram of a kind of line sweep;
Fig. 4 is the confocal ophthalmoscope system and method for a kind of line sweep based on laser diffraction structure chart;
Fig. 5 is the confocal ophthalmoscope system and method for a kind of line sweep based on laser diffraction light path schematic diagram;
Fig. 6 is living human eye retina dynamic imaging device and the method that band of the present invention surely looks like function;
Fig. 7 is living human eye retina dynamic imaging device and the method light path schematic diagram that band of the present invention surely looks like function;
In Fig. 1, 1. lighting source, 2. filter lens, 3. photoswitch, 4. light beam modulation module, 5. beacon light source, 6. Wavefront sensor, 7. wave-front corrector, 8. imaging camera, 9. translation stage, 10. tested human eye, 11. collimating lens, 12. expand the light group, 13. contracting bundle light group, 14. beam size coupling light group, 15. imaging len, 16～18. reflecting mirrors, 19～21. spectroscopes, 22. circuit system, 23.PC machine, 24. by 5, 6, 7 ADAPTIVE OPTICS SYSTEMS that form, 25. by 1, 2, 3, 4 illuminators that form, 26. by 8, 9, 15 imaging systems that form, 27. by 22, 23 control system that form.
In Fig. 7,2. spectrophotometric unit, 3. human eye, 5. tilting mirror, the 6.4f battery of lens, other labels are as shown in the figure Chinese word.
The specific embodiment
As shown in Figure 6, for band of the present invention surely looks like living human eye retina dynamic imaging device and the method structural representation of function, band of the present invention surely looks like the living human eye retina dynamic imaging device of function, comprises the confocal unit I of line, spectrophotometric unit II, dynamic imager of living human eye retina unit IV, correcting unit V, datatron VI and signal conversion unit VII.
The confocal unit I of line is connected with spectrophotometric unit II, datatron VI, the confocal unit I of line is Chinese invention patent " the confocal Oph system and method for a kind of line sweep; application number: 201010595574.X " or Chinese invention patent " the confocal ophthalmoscope system and method for a kind of line sweep based on laser diffraction; application number: 201010595587.7 ", and the confocal unit I of line comprises Line beam generation module, spectral module, scan module, image-forming module and output module.
The confocal unit I of line can adopt the confocal Oph system and method for a kind of line sweep, and the confocal Oph system of a kind of line sweep, comprise Line beam generation module 1, spectral module 2, scan module 3, image-forming module 5 and output module 6, as shown in Figures 2 and 3.Line beam generation module 1 is connected with spectral module 2, Line beam generation module 1 consists of point source 100, collimator and extender device 110 and Line beam capture device 120, the divergent beams that point source 100 sends are by the rear output of collimator and extender device 110 collimation collimated light beam, and Line beam capture device 120 is sent into spectral module 2 by the collimated light beam intercepting of collimator and extender device 110 outputs for one dimension linear light bunch, spectral module 2 is light splitting plain film or Amici prism, and spectral module 2 arrives scanning element 3 for the direct transmission of an one dimension Line beam part that Line beam generation module 1 is produced, scan module 3 consists of scanning galvanometer 300 and illumination objective lens group 310, the Line beam of spectral module 2 direct outgoing passes through scanning galvanometer 300 and illumination objective lens group 310 successively, then from the I outgoing of the confocal unit of line, as shown in Figure 6, this Line beam enters human eye III optical fundus after spectrophotometric unit II deflecting reflection, the imaging line light beam returned from fundus reflex is in the confocal unit I of spectrophotometric unit II deflecting reflection loop line, pass through successively illumination objective lens group 310 and scanning galvanometer 300 synchronous reflections to spectral module 2, spectral module 2 reflexes to image-forming module 5 by the imaging line beam deflection, image-forming module 5 is by image-forming objective lens 500, cylindrical lens 510, confocal slit 520 and line detector 530 form, the imaging line light beam of spectral module 2 deflection outgoing passes through image-forming objective lens 500 successively, cylindrical lens 510 and confocal slit 520, arrive line detector 530 and convert the signal of telecommunication to by light intensity signal, and be transferred to output module 6, confocal slit 520 and human eye III retinal plane conjugation, the veiling glare that confocal slit 520 can be got rid of non-human eye III retinal plane enters line detector 530, thereby realize the high-resolution of confocal imaging principle, output module 6 consists of image pick-up card 600 and outut device 610, and image pick-up card 600 converts the signal of telecommunication of image-forming module 5 outputs to picture signal, and by outut device 610 outputs, outut device 610 is connected with datatron VI, the retina image-forming result that outut device 610 is obtained is exported to datatron VI, datatron VI calculates the retina shake by algorithm, and solution is counted as the discrete control voltage transmission of correction retina shake to signal conversion unit VII.
The confocal unit I of line also can adopt the confocal ophthalmoscope system of a kind of line sweep based on laser diffraction, the confocal ophthalmoscope system of a kind of line sweep based on laser diffraction comprises Line beam generation module 1, spectral module 2, scan module 3, image-forming module 5 and output module 6, as shown in Figure 4 and Figure 5, Line beam generation module 1 is connected with spectral module 2, Line beam generation module 1 is by point source 100, collimator apparatus 110 and Line beam converting means 120 form, the divergent beams of point source 100 are transformed to collimated light beam through collimator apparatus 110, this collimated light beam is transformed to the one dimension Line beam through Line beam converting means 120 and is transmitted to spectral module 2, spectral module 2 is light splitting plain film or Amici prism, for the direct transmission of an one dimension Line beam part that Line beam generation module 1 is produced, arrives scan module 3, scan module 3 consists of scanning galvanometer 300 and illumination objective lens 310, the Line beam of spectral module 2 direct outgoing passes through scanning galvanometer 300 and illumination objective lens 310 successively, then from the I outgoing of the confocal unit of line, as shown in Figure 6, this Line beam enters human eye III optical fundus after spectrophotometric unit II deflecting reflection, the imaging line light beam returned from fundus reflex is in the confocal unit I of spectrophotometric unit II deflecting reflection loop line, pass through successively illumination objective lens group 310 and scanning galvanometer 300 synchronous reflections to spectral module 2, spectral module 2 reflexes to image-forming module 5 by the imaging line beam deflection, image-forming module 5 consists of image-forming objective lens 500, cylindrical lens 510, confocal slit 520 and line detector 530, the imaging line light beam of spectral module 2 deflection outgoing passes through image-forming objective lens 500, cylindrical lens 510 and confocal slit 520 successively, arrive line detector 530 and convert the signal of telecommunication to by light intensity signal, and be transferred to output module 6, confocal slit 520 and human eye III retinal plane conjugation, the veiling glare that confocal slit 520 can be got rid of non-human eye III retinal plane enters line detector 530, thereby realizes the high-resolution of confocal imaging principle, output module 6 consists of image pick-up card 600 and outut device 610, and image pick-up card 600 converts the signal of telecommunication of image-forming module 5 outputs to picture signal, and by outut device 610 outputs, outut device 610 is connected with datatron VI, the retina image-forming result that outut device 610 is obtained is exported to datatron VI, datatron VI calculates the retina shake by algorithm, and solution is counted as the discrete control voltage transmission of correction retina shake to signal conversion unit VII.
Dynamic imager of living human eye retina unit IV is connected with correcting unit V, for Chinese invention patent " dynamic imager of living human eye retina, publication No.: CN 101926640 A ", as shown in Figure 1, comprise lighting source 1, filter lens 2, photoswitch 3, light beam modulation module 4, beacon light source 5, Wavefront sensor 6, wave-front corrector 7, imaging camera 8, translation stage 9, collimating lens 11, expand light group 12, contracting bundle light group 13, beam size coupling light group 14, imaging len 15, reflecting mirror 16～18, spectroscope 19～21, circuit system 22, PC 23, by 5, 6, 7 ADAPTIVE OPTICS SYSTEMS 24 that form, by 1, 2, 3, 4 illuminators 25 that form, by 8, 9, 15 imaging systems 26 that form, by 22, 23 control system 27 that form.Beacon light source 5 sends beacon beam, after collimating lens 11 collimations, enter correcting unit V of the present invention successively after spectroscope 19, spectroscope 20 reflections, as shown in Figure 6, the tilting mirror in correcting unit V is propagated and is entered human eye III through 4f battery of lens, the direct transmission of spectrophotometric unit II successively through the synchronous reflection continuation beacon beam.The beacon beam of human eye III retinal reflex is after human eye III outgoing, pass through successively spectrophotometric unit II, entering dynamic imager of living human eye retina of the present invention unit IV after 4f battery of lens in correcting unit V and tilting mirror propagates, as shown in Figure 1, particularly, the reflection beacon beam is in spectroscope 20 places transmission, then after expanding light group 12, by wave-front corrector 7, reflected, then be reflected mirror 17 reflections after contracting bundle light group 13, the secondary reflection again in spectroscope 21 places, mate light group 14 by beam size, finally enter Wavefront sensor 6 and carry out the detection of facula mass center side-play amount, detection data is sent into circuit system 22 processing and is obtained wavefront slope.PC 23 restores full refraction of eye system wave aberration according to the wavefront slope of gained on the one hand, 22 pairs of wavefront slope of circuit system are done further to calculate on the other hand, obtain the corresponding correction time required correction signal applied of wave aberration, and it is amplified to rear drive wavefront appliance 7 real-Time Compensation because of the Beam Wave-Front that human eye 10 aberrations distort, imaging system is remained approach the optimum state of resolution of diffraction.After the completion system aberration correction, circuit system 22 maintains Adaptable System 24 and works on and notify PC 23, and instrument starts imaging immediately.Circuit system 22 produces the modulation signal of photoswitch 3 and the synchronizing signal of coordinating photoswitch 3 and imaging camera 8.This modulation signal is loaded into photoswitch 3, photoswitch 3 transfers by initial closed condition the control signal work of following to, so, the continuous light that lighting source 1 sends is successively through filter lens 2, photoswitch 3 modulation become pulsed light, then this pulsed light is through reflecting mirror 16 reflections, through spectroscope 19, again through spectroscope 20 reflections, thereby enter correcting unit V of the present invention, as shown in Figure 6, tilting mirror in the jitter corrected signal modulation correcting unit V of signal conversion unit VII output, tilting mirror is modulated in real time and is proofreaied and correct the retina shake imaging beam, imaging beam continues to propagate the interior 4f battery of lens of calibrated unit V successively, the direct transmission of spectrophotometric unit II enters human eye III.The imaging beam of human eye III retinal reflex is after human eye III outgoing, pass through successively spectrophotometric unit II, 4f battery of lens in correcting unit V and tilting mirror synchronous reflection enter dynamic imager of living human eye retina of the present invention unit IV and propagate, as shown in Figure 1, particularly, the catoptric imaging light beam is in spectroscope 20 places transmission, then after expanding light group 12, by wave-front corrector 7, reflected, then be reflected mirror 17 reflections after contracting bundle light group 13, the secondary reflection again in spectroscope 21 places, until spectroscope 21 places transmission, then through reflecting mirror 18 reflections, finally by imaging len 15, focused on imaging camera 8 target surfaces.Imaging camera 8 coordinates the exposure of photoswitch synchronizing sequence according to the synchronizing signal of circuit system 22 generations, quick continuous acquisition multiframe optical fundus retina high-definition picture in a period of time, and send PC 23 to real-time video or dynamic image sequence demonstration.Therefore, the dynamic continuous imaging of the living human eye retina unit IV the inventive system comprises can directly gather and obtain living human eye retina high-resolution, non-jitter real-time video or image sequence demonstration.
Datatron VI is connected with the confocal unit I of line, signal conversion unit VII, the imaging results of the confocal unit I of line is exported to datatron VI, datatron VI extracts retina shake from imaging results, and solution is counted as the discrete control voltage of proofreading and correct the retina shake, exports to signal conversion unit VII;
Signal conversion unit VII is connected with datatron VI, correcting unit V, signal conversion unit VII consists of D/A switch device and high-voltage amplifier, the discrete control voltage that datatron VI resolves the correction retina shake obtained is converted into analog quantity through the D/A switch device, and analog quantity is controlled voltage and be transferred to correcting unit V after high-voltage amplifier is amplified.
Correcting unit V is connected with signal conversion unit VII, dynamic imager of living human eye retina unit IV and spectrophotometric unit II, correcting unit V consists of tilting mirror and 4f battery of lens, correcting unit V is subject to the control Control of Voltage of signal conversion unit VII output, be transmitted to spectrophotometric unit II after the imaging beam of dynamic imager of living human eye retina unit IV is modulated, realized the real time correction to the retina shake.
As shown in Figure 7, band of the present invention surely looks like the living human eye retina dynamic imaging method of function, comprises the following steps:
Step 1, the imaging line light beam of the confocal unit 1 of line reflexes to intelligent's eye 3 retinas through spectrophotometric unit 2;
Step 4, the imaging results that the confocal unit 1 of 7 pairs of lines of datatron obtains is carried out computing, obtains the measured value of retina shake;
Step 7, analog quantity is controlled voltage after high-voltage amplifier 9 amplifies, and transfers to tilting mirror 5;
Step 8, the imaging beam of dynamic imager of living human eye retina unit 4, after tilting mirror 5 modulation in real time, directly is transmitted to intelligent's eye 3 retinas successively after 4f battery of lens 6 and spectrophotometric unit 2;
Step 9, the imaging beam that human eye 3 retinal reflexs return successively after spectrophotometric unit 2 and 4f battery of lens 6, then goes back to dynamic imager of living human eye retina unit 4 through tilting mirror 5 synchronous reflections;
As shown in Figure 7, be light path schematic diagram of the present invention, the solid line between block diagram means the light path propagation path, dotted line is depicted as the propagation of electrical signals path, and light beam is all propagated along the system primary optical axis, and the signal of telecommunication is propagated by the associated wiring, be illustrative nature in figure, do not mean real optical design parameter.
The confocal unit 1 of line is Chinese invention patent " the confocal Oph system and method for a kind of line sweep; application number: 201010595574.X " or Chinese invention patent " the confocal ophthalmoscope system and method for a kind of line sweep based on laser diffraction, application number: 201010595587.7 ".
Dynamic imager of living human eye retina unit 4 is for being Chinese invention patent " dynamic imager of living human eye retina, publication No.: CN 101926640 A ".
Tilting mirror 5 is for reflecting at a high speed tilting mirror.
4f battery of lens 6 is comprised of the lens of two parfocals, and two gummed achromats that in the present embodiment, two focal lengths of employing are 50mm form.
Datatron 7 is analog control circuit or digital computer.
The present invention does not limit to and above-mentioned example, and persons skilled in the art can adopt numerous embodiments to realize the present invention according to content disclosed by the invention.
Non-elaborated part of the present invention belongs to techniques well known.
Claims (9)
1. the living human eye retina dynamic imaging device of the steady picture of a band function, is characterized in that: comprise correcting unit and spectrophotometric unit;
Correcting unit is connected with signal conversion unit, dynamic imager of living human eye retina unit and spectrophotometric unit, correcting unit consists of tilting mirror and 4f battery of lens, the control Control of Voltage tilting mirror that signal conversion unit is exported is modulated and is proofreaied and correct the retina shake the imaging beam of dynamic imager of living human eye retina unit output, and light splitting cell illumination human eye optical fundus is crossed in the imaging beam direct transmission after the 4f battery of lens be tilted after mirror is modulated;
Spectrophotometric unit is connected with correcting unit, the confocal unit of line and human eye, spectrophotometric unit is dichroic light splitting plain film or dichroic Amici prism, for the dynamic imager of living human eye retina illuminating bundle of correcting unit outgoing directly is transmitted to intelligent's eye, from the direct transmission of the dynamic imager of living human eye retina imaging beam of human eye retina's outgoing, arrive correcting unit; With will arrive human eye from the Line beam deflecting reflection of line confocal unit outgoing, arrive the confocal unit of line from the Line beam deflecting reflection of human eye retina's outgoing;
Also comprise dynamic imager of living human eye retina unit, the confocal unit of line, signal conversion unit and datatron;
The dynamic imager of living human eye retina unit is connected with correcting unit, the dynamic imager of living human eye retina unit is dynamic imager of living human eye retina, for human eye retina's imaging, comprise illuminator, imaging system, control device and ADAPTIVE OPTICS SYSTEMS, transmit after the calibrated cells modulate of the outgoing beam of dynamic imager of living human eye retina unit;
The confocal unit of line is connected with spectrophotometric unit, datatron, the confocal unit of line is for surveying human eye retina's shake, the confocal unit of line comprises Line beam generation module, spectral module, scan module, image-forming module and output module, the emergent ray light beam of the confocal unit of line arrives the human eye optical fundus through the spectrophotometric unit deflecting reflection, the imaging line light beam gone out from fundus reflex is through the confocal unit of spectrophotometric unit deflecting reflection loop line detection imaging, and imaging results is exported to datatron for calculating the retina shake;
Datatron is connected with the confocal unit of line, signal conversion unit, the imaging results of the confocal unit of line is exported to datatron, datatron adopts algorithm to extract the retina shake from imaging results, and solution is counted as the discrete control voltage of proofreading and correct the retina shake, exports to signal conversion unit;
Signal conversion unit is connected with datatron, correcting unit, signal conversion unit consists of D/A switch device and high-voltage amplifier, the discrete control voltage that datatron resolves the correction retina shake obtained is converted into analog quantity through the D/A switch device, and analog quantity is controlled voltage and be transferred to correcting unit after high-voltage amplifier is amplified.
2. band according to claim 1 surely looks like the living human eye retina dynamic imaging device of function, it is characterized in that: the confocal unit of described line is the confocal ophthalmoscope system of a kind of line sweep.
3. band according to claim 1 surely looks like the living human eye retina dynamic imaging device of function, it is characterized in that: the confocal unit of described line is the confocal ophthalmoscope system of a kind of line sweep based on laser diffraction.
4. band according to claim 1 surely looks like the living human eye retina dynamic imaging device of function, it is characterized in that: described tilting mirror is for reflecting at a high speed tilting mirror.
5. band according to claim 1 surely looks like the living human eye retina dynamic imaging device of function, it is characterized in that: described datatron is analog control circuit or digital computer.
6. a band, surely as the living human eye retina dynamic imaging method of function, is characterized in that performing step is as follows:
Step 1, the emergent ray light beam of the confocal unit of line reaches the human eye retina through the spectrophotometric unit deflecting reflection, the imaging line light beam reflected from human eye is through the confocal unit of spectrophotometric unit deflecting reflection loop line, the confocal unit of line carries out detection imaging to the imaging line light beam, obtains human eye retina's high frame frequency imaging results;
Step 2, the high frame frequency imaging results of the retina that the confocal unit of processor pair line obtains is carried out computing, obtains proofreading and correct the control voltage of retina shake, and is transferred to correcting unit through signal conversion unit;
Step 3, the calibrated unit of the outgoing beam of dynamic imager of living human eye retina unit modulation in real time directly shines intelligent's eyes retina by spectrophotometric unit, the imaging beam reflected from human eye is transmitted to correcting unit after the direct transmission of spectrophotometric unit, correcting unit returns the imaging beam synchronous reflection to dynamic imager of living human eye retina unit detection imaging, obtains amphiblestroid non-jitter high-resolution imaging;
Described step 1 comprises:
Step 11, the confocal unit of line emergent ray light beam arrives the human eye retina through the spectrophotometric unit deflecting reflection;
Step 12, the imaging line light beam reflected from the human eye retina is through the confocal unit of spectrophotometric unit deflecting reflection loop line;
Step 13, the confocal unit of line is surveyed the imaging line light beam, obtains human eye retina's high frame frequency imaging results;
Described step 2 comprises:
Step 21, the imaging results that the confocal unit of processor pair line obtains is carried out computing, obtains the measured value of retina shake;
Step 22, the measured value of processor pair retina shake is resolved, and obtains proofreading and correct the control voltage of retina shake;
Step 23, the control Voltage-output of the positive retina shake of datatron high-ranking officers is to signal conversion unit;
Step 24, control voltage and be transferred to correcting unit after the signal conversion unit conversion;
Described step 24 comprises:
Step 241, proofread and correct the control voltage of retina shake through the conversion of D/A switch device, by digital quantity, is converted to analog quantity;
Step 242, the control voltage of analog quantity, after high-voltage amplifier amplifies, transfers to correcting unit;
Described step 3 comprises:
Step 31, the outgoing beam of the dynamic imager of living human eye retina unit in real time modulation of calibrated unit and spectrophotometric unit successively directly is transmitted to intelligent's eyes retina;
Step 32, the imaging beam reflected from the human eye retina, after the direct transmission of spectrophotometric unit, goes back to the dynamic imager of living human eye retina unit through the correcting unit synchronous reflection;
Step 33, the dynamic imager of living human eye retina unit is surveyed the imaging beam of proofreading and correct through correcting unit, obtains the retina high-resolution imaging result of non-jitter;
Described step 31 comprises:
Step 311, after the modulation in real time of the calibrated unit of the outgoing beam of dynamic imager of living human eye retina unit, outgoing arrives spectrophotometric unit;
Step 312, the dynamic imager of living human eye retina unit direct transmission of outgoing beam of modulation in real time of calibrated unit is crossed spectrophotometric unit and is arrived the human eye retina;
Described step 32 comprises:
Step 321, the direct transmission of the imaging beam reflected from the human eye retina is crossed spectrophotometric unit and is arrived correcting unit;
Step 322, the calibrated units synchronization of the imaging beam directly transmitted from spectrophotometric unit is reflected back the dynamic imager of living human eye retina unit.
7. band according to claim 6 surely looks like the living human eye retina dynamic imaging method of function, it is characterized in that:
Described correcting unit consists of tilting mirror and 4f battery of lens, and tilting mirror is for reflecting at a high speed tilting mirror;
Described spectrophotometric unit is dichroic light splitting plain film or dichroic Amici prism;
Described datatron is analog control circuit or digital computer;
Described signal conversion unit is D/A switch device and high-voltage amplifier;
Described dynamic imager of living human eye retina unit is dynamic imager of living human eye retina, for human eye retina's imaging, comprises illuminator, imaging system, control device and ADAPTIVE OPTICS SYSTEMS;
The confocal unit of described line, for surveying human eye retina's shake, comprises Line beam generation module, spectral module, scan module, image-forming module and output module.
8. band according to claim 6 surely looks like the living human eye retina dynamic imaging method of function, it is characterized in that: the confocal unit of described line is the confocal Oph system of a kind of line sweep.
9. band according to claim 6 surely looks like the living human eye retina dynamic imaging method of function, it is characterized in that: the confocal unit of described line is the confocal ophthalmoscope system of a kind of line sweep based on laser diffraction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110328377.6A CN102499634B (en) | 2011-10-26 | 2011-10-26 | Living human eye retina dynamic imaging device with image stabilizing function and method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110328377.6A CN102499634B (en) | 2011-10-26 | 2011-10-26 | Living human eye retina dynamic imaging device with image stabilizing function and method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102499634A CN102499634A (en) | 2012-06-20 |
| CN102499634B true CN102499634B (en) | 2014-01-08 |
Family
ID=46211816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110328377.6A Expired - Fee Related CN102499634B (en) | 2011-10-26 | 2011-10-26 | Living human eye retina dynamic imaging device with image stabilizing function and method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102499634B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2509131B (en) * | 2012-12-21 | 2017-05-17 | Optos Plc | Improvements in and relating to ophthalmoscopes |
| CN103750814B (en) * | 2013-12-31 | 2018-07-17 | 苏州微清医疗器械有限公司 | A kind of eyeground scanned imagery device |
| CN106371577B (en) * | 2015-12-16 | 2019-02-19 | 北京智谷睿拓技术服务有限公司 | Nearly eye display control method and device |
| CN106371578B (en) * | 2015-12-16 | 2019-04-16 | 北京智谷睿拓技术服务有限公司 | Nearly eye display control method and device |
| CN109924943A (en) * | 2019-04-25 | 2019-06-25 | 南京博视医疗科技有限公司 | A kind of digital image stabilization method and system based on improved Line-scanning Image Acquisition System |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1427328B1 (en) * | 2001-08-30 | 2014-07-02 | University Of Rochester | Adaptive optics in a scanning lase ophtalmoscope |
| EP1387340A1 (en) * | 2002-07-30 | 2004-02-04 | Deutsche Thomson-Brandt Gmbh | Method and device for processing video data for a display |
| US7758189B2 (en) * | 2006-04-24 | 2010-07-20 | Physical Sciences, Inc. | Stabilized retinal imaging with adaptive optics |
| CN101316368B (en) * | 2008-07-18 | 2010-04-07 | 西安电子科技大学 | Full view stabilizing method based on global characteristic point iteration |
| CN201266295Y (en) * | 2008-08-29 | 2009-07-01 | 富士能株式会社 | Reparation unit for image dithering, reparation device for image dithering, photographic device and carrying equipment |
| CN101926640B (en) * | 2009-06-22 | 2012-05-09 | 中国科学院光电技术研究所 | Dynamic imager of living human eye retina |
| CN101742122B (en) * | 2009-12-21 | 2012-06-06 | 汉王科技股份有限公司 | Method and system for removing video jitter |
| CN102068236B (en) * | 2010-12-17 | 2012-05-23 | 中国科学院光电技术研究所 | Line-scanning confocal ophthalmoscope system based on laser diffraction and method |
| CN102008288B (en) * | 2010-12-17 | 2012-02-01 | 中国科学院光电技术研究所 | System and method for line scan confocal ophthalmoscope |
-
2011
- 2011-10-26 CN CN201110328377.6A patent/CN102499634B/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN102499634A (en) | 2012-06-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10070782B2 (en) | Adaptive optical retina imaging device and method | |
| CN102008288B (en) | System and method for line scan confocal ophthalmoscope | |
| CN102429638B (en) | Retina shaking correcting device and method on basis of image correlation | |
| CN102038487B (en) | Adaptive optics apparatus that corrects aberration of examination object and image taking apparatus | |
| KR100888867B1 (en) | Method and device for synchronous mapping | |
| CN102068236B (en) | Line-scanning confocal ophthalmoscope system based on laser diffraction and method | |
| CN103070665B (en) | Self-adapted sweep frequency optical coherence tomography imaging system based on double wave-front correctors | |
| CN102499634B (en) | Living human eye retina dynamic imaging device with image stabilizing function and method | |
| CN101862178A (en) | Reflection-type confocal scanning retina imaging system based on adaptive optics | |
| US20120133888A1 (en) | scanning ophthalmoscopes | |
| CN102860815B (en) | Line scanning confocal imaging image guidance-based self-adaption confocal scanning retina imaging method and device | |
| CN100589780C (en) | Reflection type artificial crystal optical aberration hartmann measuring apparatus | |
| CN103054550B (en) | Line scanning confocal ophthalmoscope system on basis of adaptive optics | |
| CN100586406C (en) | Transmission type artificial crystal optical aberration hartmann measuring apparatus | |
| CN101248981A (en) | Visual optics analysis system based on wave-front abberration | |
| CN102860817A (en) | Laser scanning confocal ophthalmoscope device based on two wave-front correctors | |
| CN101884524A (en) | Wide field of view optical coherence tomographic instrument based on adaptive optical technology | |
| CN102973241B (en) | Laser diffracted ray scanning confocal ophthalmoscope system based on adaptive optics | |
| CN102008289A (en) | Aberration compensation fundus microscope based on automatic optimization algorithm | |
| CN102860816B (en) | Retina three-dimensional imaging device based on double wavefront correctors for human eyes | |
| CN102499628B (en) | Three-dimensional imaging device and method with image stabilizing function for retina of human eye of living body | |
| US8009280B1 (en) | Wavefront characterization and correction | |
| CN102188231B (en) | Zoom multi-channel microscopic imaging system of eye retina | |
| CN203953620U (en) | A kind of multispectral retina confocal scanning imaging system based on adaptive optics | |
| CN102389290B (en) | Frequency-domain optical coherence tomography system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140108 Termination date: 20211026 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |