CN102269667B - Automatic storing and taking control system for biomedical sample refrigeration - Google Patents
Automatic storing and taking control system for biomedical sample refrigeration Download PDFInfo
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- CN102269667B CN102269667B CN 201110167022 CN201110167022A CN102269667B CN 102269667 B CN102269667 B CN 102269667B CN 201110167022 CN201110167022 CN 201110167022 CN 201110167022 A CN201110167022 A CN 201110167022A CN 102269667 B CN102269667 B CN 102269667B
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Abstract
The invention provides an automatic storing and taking control system for biomedical sample refrigeration. The system comprises a refrigerating chamber, an automatic storing and taking gate, a sample database, an automatic sample conveying mechanism, a bar-code scanner, a programmable logic controller and a host computer. Specifically, the refrigerating chamber is an obturator, the automatic storing and taking gate unit is disposed between the external environment and the refrigerating chamber environment, and the sample database and the automatic sample conveying mechanism are both arranged inside the refrigerating chamber; the bar-code scanner is mounted on a sample conveying path; sensors and dynamic components in the automatic storing and taking gate, the sample database and the automatic sample conveying mechanism are all connected to the programmable logic controller; the bar-code scanner and the programmable controller are both in connection with the host computer. Characterized by simple structure and high capacity for sample storage, the system of the invention realizes automatic sample storing and taking and intelligent data management. Installed with two gates, the system of the invention effectively isolates the internal and external environments and avoids refrigeration environment fluctuation caused by door opening, thus guaranteeing stable refrigeration environment and sample quality and safety and being easy to realize remote monitoring.
Description
Technical field
The present invention relates to a kind of automatically depositing in when storing under cold storage environment for the biological medicine sample in the system that takes out, belong to the sample storage technical field.
Background technology
Sample size in the laboratory of biomedicine field is many, batch more than, most of research institutions do not have special sample management system, the written management of management and using long-term implementation of sample, cause that the sample utilization factor is low, information delay, can't the real-time follow-up achievement in research etc. problem.Add that flow of personnel is large, achievement in research can not be shared, and the experimental work handover procedure is loaded down with trivial details, and reagent and the handing-over of compound equal samples are not had unified standard, has brought larger difficulty for preservation, use and the management work of sample.
Improvement along with HIGH POWER PROTON ACCELERATOR, the biology laboratory sample size increases gradually, simple unordered sample managing pattern in the past can not adapt to present need of work, the management in laboratory remains further to be improved, how more efficiently, easily the scientific management of managing laboratory sample and be biological products and chemicals in key subjects, the especially laboratory of being badly in need of at present solving just seems especially important for fast development and the orderly function in whole laboratory.At present in the urgent need to a kind of efficiently, the sample access system satisfies in the Development of Laboratories process the accurate needs of management of sample easily.
At present, the bottleneck of restriction China biological medicine research is instrument and equipment, and relevant high-end instrument and equipment is import mostly, and can not give full play to their function, the more important thing is to can't buy state-of-the-art instrument and equipment.Domestic many research institutions do not have special sample management system, the written management of management and using long-term implementation of sample, cause that the sample utilization factor is low, information delay, can't the real-time follow-up achievement in research etc. problem.Sample Storehouse both domestic and external, from preserving on the container, the main traditional refrigerator (cabinet) that adopts is preserved, and part has adopted the liquid nitrogen container preservation, the fraction pilot has also been arranged very mechanical arm automated sample storehouse.From data management, major part also rests on the simple data storehouse epoch, only has the part Sample Storehouse to develop private database, and has done interface with large database.
The biological medicine sample need to store under freezing or cold storage environment, also can take out from freezing or cold storage environment simultaneously, no matter be the sort of situation, the chamber door of cold storage environment (such as refrigerator, refrigerator-freezer) need to be opened in the capital, sometimes opening is frequently, this just causes the convection current of inner air and outer air, certainly will cause like this cold storage environment (temperature, humidity etc.) to change, and affects the stable of storage condition.Studies show that, pharmaceutical preparation, medicine performance, biological specimen (blood plasma, serum, whole blood, lymph, saliva, various tissue, hair, urine, bile, tear, spinal fluid, sweat, milk, amniotic fluid etc.), vaccine store and the storage condition (temperature, humidity etc.) of vegetables meat all has a significant impact its performance, quality.
Existing refrigerating equipment (such as refrigerator, refrigerator-freezer) all is to deposit or take out article by a larger chamber door is set.Article are when storing and take out, the chamber door of cold storage environment (such as refrigerator, refrigerator-freezer) need to be opened in the capital, sometimes opening is frequently, and this just causes the convection current of inner air and outer air, certainly will cause like this cold storage environment (temperature, humidity etc.) to change, affect the stable of storage condition, particularly storage condition is required harsh article, small storage condition changes all can affect its quality, also can make freezing or refrigerating equipment frequent starting simultaneously, increase power consumption, improve storage cost.
The quantity of sample is on the increase, and needs the quantity of information of record also increasing, and in the face of so many information, traditional way to manage seems awkward.At present, there is not to satisfy the product of this demand on the market, and this product is to storage, the management and using particular importance of sample, free from loaded down with trivial details sample management for the storage quality that improves sample with the researchist, must research and develop a kind of automatic sampling, the metering that can under cold storage environment, finish sample according to the research process requirements, novel sample automatic access and the intelligent management system that can carry out to the sample operating position again registration management.
No matter domestic or external, the unit of research data base is many, provides the enterprise of freezing equipment also very well-known, and still, the successful case that sample technique of refrigeration, sample automatic access technology and sample data library management are combined does not also have.
Summary of the invention
The present invention is directed to the deficiency that existing biological medicine sample storage technology exists, the biological medicine sample refrigeration access automatic control system that a kind of memory capacity is large, can realize efficient, safety, automatic access and management is provided.
Biological medicine sample refrigeration access automatic control system of the present invention adopts following technical solution:
This biological medicine sample refrigeration access automatic control system comprises reefer, automatic access sluice gate, Sample Storehouse, sample automatic delivering mechanism, barcode scanner, Programmable Logic Controller (PLC) and host computer; Reefer is an obturator, and the automatic access sluice gate is arranged on the reefer sidewall, and Sample Storehouse and sample automatic delivering mechanism all are arranged in the reefer; Barcode scanner is installed in sample and carries on the path of process; Sensor in automatic access sluice gate, Sample Storehouse and the sample automatic delivering mechanism and execution unit all are connected with Programmable Logic Controller; Barcode scanner and Programmable Logic Controller all are connected with host computer;
The automatic access sluice gate, it is the transition passage that is used for the access sample that reefer and space outerpace contact, be provided with flood tide gate between this transition passage and the external environment condition, and be provided with interior automatically-controlled door between the cold storage environment, be provided with a zone of transition between flood tide gate and the interior automatically-controlled door, be provided with in the zone of transition with the outside gas access that is communicated with of reefer and exhausr port, with cryogenic gas entrance and the protective gas entrance of reefer internal communication, on these mouths valve is installed all; Be provided with pressure transducer and Temperature Humidity Sensor in the zone of transition; The sample pallet of a movement is set in the inboard that interior automatically-controlled door is in reefer, and the inboard of sample pallet is provided with a delivery device;
Sample Storehouse comprises central shaft, sample storage disk and disk driving mechanism; The central shaft bottom is installed on the pedestal, each sample storage disk is installed in parallel on the central shaft, be provided with sealing gasket between the adjacent sample storage disk, be distributed with sample nest and sample transmission channel on the sample storage disk, corresponding to all sample storage disks one cover disk driving mechanism is set at least, the disk driving mechanism is installed on the support that is fixed in pedestal, the sample nest adopts many form of annular rings to be arranged on the sample storage disk, the sample nest is circular distribution, number of rings is at least two rings, all annulus are with one heart, and a sample transmission channel is set on each annulus at least;
The sample automatic delivering mechanism, comprise lifting apparatus and absorption conveying device, lifting apparatus is arranged on the below of bottom sample storage disk, comprise and lift air jet pipe and jet operation valve, arrange one corresponding to each the sample transmission channel on the bottom sample storage disk and lift air jet pipe, lift and be connected with jet operation valve on the air jet pipe, lift air jet pipe and be connected with source of the gas; The absorption conveying device is arranged on the top of top layer sample storage disk, comprise the air-breathing seat of combination, air intake duct, suction control valve, delivery pipe, pipage control valve and vacuum storehouse, corresponding to each the sample transmission channel on the top layer sample storage disk air intake duct is set, be connected with suction control valve on the air intake duct, each air intake duct all is connected with the vacuum storehouse, delivery pipe one end is connected with the vacuum storehouse, and an end is connected to the sample pallet, is connected with the pipage control valve on the delivery pipe.
Described disk driving mechanism comprises servomotor and gear train, and servomotor is connected with the input end of gear train, and the output terminal of gear train is connected on the rotating circular disk.Gear train can adopt with the various mechanisms that disk is rotated such as transmission, toothed belt transmission, gear drive, rack-and-pinion transmission.
The present invention has changed the opening/shutting mode of traditional cold storage environment, can realize the automatic access of sample, has characteristics simple in structure, that the sample storing capacity is large; Have temperature, humidity coupling control function, have inert gas protection device, reduce the fluctuation of cold storage environment as far as possible, avoided the variation of cold storage environment, guaranteed the stable of cold storage environment, ensured sample quality and safety; Can get up the storage of sample and sample data information association, allow the researchist from loaded down with trivial details sample management, free.
Description of drawings
Fig. 1 is structured flowchart of the present invention.
Fig. 2 is the structural representation of automatic access sluice gate among the present invention.
Fig. 3 is the structure vertical view of Sample Storehouse and sample automatic delivering mechanism among the present invention.
Fig. 4 is the structural front view of Sample Storehouse and sample automatic delivering mechanism among the present invention.
Fig. 5 is that specimen bottle deposits process flow diagram in.
Wherein: 1. reefer, 2. automatic access sluice gate, 3. Sample Storehouse, 4. sample automatic delivering mechanism, 5. barcode scanner, 6. Programmable Logic Controller, 7. host computer; 201. flood tide gate, 202. interior automatically-controlled door, 203. zone of transition, 204. sample pallets, 205. reefer is inner, 206. reefer is outside, 2031. extraneous gas entrances, 2032. protective gas entrances, 2033. cryogenic gas entrance, 2034. exhausr port, 2035. temperature and humidity controllers, 2036. pressure controllers; 301. the sample storage disk, 302. sample nests, 303. sample transmission channels, 304. sealing gaskets, 305. specimen bottles, 306. pedestals, 307. central shafts; 401. make up air-breathing seat, 402. suction control valves, 403. air intake ducts, 404. vacuum pumps, 405. vacuum control valves, 406. vacuum storehouses, 407. lift air jet pipe, 408. jet operation valves, 409. air compressor, 410. delivery pipes, 411. pipage control valves.
Embodiment
As shown in Figure 1, biological medicine sample refrigeration access automatic control system of the present invention comprises reefer 1, automatic access sluice gate 2, Sample Storehouse 3, sample automatic delivering mechanism 4, barcode scanner 5 and Programmable Logic Controller 6 and host computer 7.Reefer 1 is an obturator, and is substantially the same with the structure of existing refrigerator-freezer, just seals all around, only is provided with an automatic access sluice gate 2 at sidewall., and at this automatic access sluice gate 2 is set.Sample Storehouse 3 all is arranged in the reefer 1 with sample automatic delivering mechanism 4.
Below the structure of automatic access sluice gate 2, Sample Storehouse 3 and sample automatic delivering mechanism 4 is elaborated.
The structure of automatic access sluice gate 2 is a transition passage that is arranged on reefer 1 sidewall as shown in Figure 2, is between external environment condition and the reefer environment.Be provided with flood tide gate 201 between this transition passage and the reefer outside 206, and be provided with interior automatically-controlled door 202 between the reefer inside 205, be provided with a zone of transition 203 between flood tide gate 201 and the interior automatically-controlled door 202.Interior automatically-controlled door 202 can adopt the automatically-controlled door of light-operated automatically-controlled door or alternate manner control.Flood tide gate 201 can adopt manually operated door, also can adopt automatically-controlled door.A side setting of zone of transition 203 is communicated with reefer inner 205 cryogenic gas entrance 2033 and with reefer outside 206 exhausr ports that are communicated with 2034; opposite side arranges and the reefer outside 206 extraneous gas entrances 2031 that are communicated with and the protective gas entrance 2032 that is communicated with the outer protection gas source; on these mouthfuls valve is installed all, in order to open or close.Extraneous gas entrance 2031 is communicated with external environment condition, and cryogenic gas entrance 2033 is communicated with cold storage environment, and protective gas entrance 2032 is communicated with the outer protection gas source, and protective gas is all kinds of gases that are applicable to article protection, such as various inert gases.At zone of transition 203 interior installation temperature and humidity controller 2035 and pressure controllers 2036, so that regulation and control zone of transition 203 environment.Interior automatically-controlled door 202 inboards arrange a transportable sample pallet 204, the inboard of sample pallet 204 is provided with a delivery device (not drawing among Fig. 2), this delivery device can be cylinder, hydraulic cylinder, electric pushrod or a mechanical arm, also can be other mechanism that can make the specimen bottle on the sample pallet 204 push zone of transition 203 or take out zone of transition 203.The sample pallet enters zone of transition from the cold storage environment chamber be to advance by delivery device, and the delivery device action is carried out synchronously with interior automatically-controlled door action, by PLC control, enters zone of transition from external environment, by manual propelling.
The course of work of automatic access sluice gate 2 is as follows:
One. take out sample from reefer inner 205
1. first according to the preservation characteristics that will take out sample; build a transitional environment in zone of transition 203; pass into extraneous gas to improve temperature or the humidity in the zone of transition 203 by extraneous gas entrance 203 1, pass into protective gas by protective gas entrance 2032.By temperature and humidity controller 2035 detect and control zone of transition 203 in humiture, according to sample humiture is changed requirement, determine the unlatching of extraneous gas entrance 2031 or close.Also to according to its requirement, by the pressure that pressure controller 2036 detects in the zone of transition 203, control the protective gas intake to some samples with specific (special) requirements.
2. sample automatic delivering mechanism 4 is placed into the specimen bottle 305 (referring to Fig. 4) that deposits in the Sample Storehouse 3 on the sample pallet 204 of interior automatically-controlled door 202 inboards automatically.
When needs sample pallet 204 by reefer when interior automatically-controlled door 202 is transported to zone of transition 203, interior automatically-controlled door 202 according to PLC instruction automatically open, by the delivery device in the cold storage environment zone specimen bottle 405 on the sample pallet 204 is delivered to zone of transition 203, delivery device is return.
4. sample stays for some time in zone of transition 203, and adapt to gradually external environment condition, to avoid since the rapid variation of environment sample is impacted, shift when requiring when specimen bottle 305 meets sample in humiture, pressure and the retention time of zone of transition 203, open flood tide gate 201 specimen bottle 305 is taken away.
Two. by outside 206 stored samples of reefer
1. be the same with the 1st step of taking out sample from reefer inner 205.
2. open flood tide gate 201 sample pallet 204 is put into zone of transition 3, sample stays for some time in zone of transition 203, make first gradually cooling of sample, adapt to gradually cold storage environment, to avoid since the rapid variation of environment sample is impacted, then interior automatically-controlled door 202 is according to PLC instruction unpack (beginning timing) when opening flood tide gate 201, and delivery device stretches out brings sample pallet 204 into, by sample automatic delivering mechanism 4 specimen bottle 305 is deposited in the Sample Storehouse 3 again.
The structure of Sample Storehouse 3 comprises central shaft 307, sample storage disk 301 and disk driving mechanism as shown in Figure 3 and Figure 4, and central shaft 307 bottoms are installed on the pedestal 306.Plural sample storage disk 301 is installed on the central shaft 307, and sample storage disk 301 is installed in up and down on the central shaft 307 abreast by bearing, is provided with sealing gasket 304 between the adjacent sample storage disk 301.Be distributed with sample nest 302 and sample transmission channel 303 (referring to Fig. 1) on the sample storage disk 301.Sample nest 302 on the sample storage disk 301, sample nest 302 adopts many loop types to be arranged on the sample storage disk 301, and sample nest 302 is circular distribution, and number of rings is at least two rings, all annulus are with one heart, and a sample transmission channel 303 is set on each annulus at least.Can be symmetrical arranged two sample transmission channels (namely the angle of two sample transmission channels equals 180 degree) at each annulus, the center of the sample transmission channel on all annulus is on the diameter, when the access sample, driving mechanism only need to allow disc rotary≤90 degree just can find suitable sample transmission channel like this.Corresponding to all sample storage disks one cover disk driving mechanism (disk driving mechanism not shown in FIG.) is set at least, can be that each disk arranges a cover driving mechanism, also can be that several disks or all disks share a cover driving mechanism, if several disks or all disks share a cover driving mechanism, this driving mechanism can slide up and down by elevating mechanisms such as screw pairs, just this driving mechanism is moved to this disk place when needing to rotate some disks, be connected with this disk, certainly this driving mechanism must be the gear train that can move, such as gear drive.Each overlaps the disk driving mechanism and is installed on the support, and this support is fixed on the pedestal 306.The disk driving mechanism comprises servomotor and gear train, servomotor is installed on the described support, gear train can adopt the band transmission, and (driving wheel is installed on the servomotor, sample storage disk 301 is made engaged wheel), (driving gear is installed on the servomotor in gear drive, sample storage disk 301 is made follower gear), the various mechanisms that sample storage disk 301 is rotated such as rack-and-pinion transmission (setting-up eccentricity wheel band carry-over bar moves back and forth on the servomotor, and sample storage disk 301 is made follower gear).
The structure of sample automatic delivering mechanism comprises lifting apparatus and absorption conveying device as shown in Figure 3 and Figure 4.Lifting apparatus is arranged on the below of bottom sample storage disk, comprise and lift air jet pipe 407 and jet operation valve 408, arrange one corresponding to each the sample transmission channel 303 on the sample storage disk 301 and lift air jet pipe 407 (only drawing among Fig. 2), lift and be connected with jet operation valve 408 on the air jet pipe 407, jet operation valve 408 adopts autocontrol valve (solenoid valve etc.), lift air jet pipe 407 and be connected with source of the gas, source of the gas adopts air compressor 409.Lifting air jet pipe 407 can be fixed on the support that the disk driving mechanism is installed.By opening jet operation valve 408, make pressure gas enter sample transmission channel 303 and sample nest 302 by lifting air jet pipe 407, the specimen bottle 305 in the sample nest 302 is upwards lifted.The absorption conveying device is arranged on the top of a sample storage disk of the superiors, comprise air intake duct 403, suction control valve 402, delivery pipe 410, delivery pipe operation valve 411 and vacuum storehouse 406, corresponding to each the sample transmission channel 303 on the sample storage disk 301 air intake duct 403 is set, is connected with suction control valve 402 on the air intake duct 403.For being convenient to install and operation, also each air intake duct 403 can be connected on the air-breathing seat 401 of combination, make up and be provided with the air entry corresponding with each sample transmission channel 303 for air-breathing 401.Each air intake duct 403 or make up air-breathing seat 401 and can be fixed on the support that the disk driving mechanism is installed.Each air intake duct 403 all is connected with vacuum storehouse 406.Delivery pipe 410 1 ends are connected with vacuum storehouse 406, are connected with delivery pipe operation valve 411, one ends on the delivery pipe 410 and are connected to sample pallet 204.Suction control valve 402 and delivery pipe operation valve 411 adopt autocontrol valve (solenoid valve etc.).Vacuum storehouse 406 is connected with vacuum pump 404, connecting line is provided with vacuum control valve 405, can vacuum meter be installed in vacuum storehouse 406, make vacuum storehouse 406 interior generation negative pressure by vacuum pump 404, open suction control valve 402,403 pairs of sample transmission channels 303 of air intake duct and 302 suctions of sample nest are with specimen bottle 305 sucking-offs in the sample nest 302.Lifting the lifting under the swabbing action with air intake duct 403 of air jet pipe 407, specimen bottle 305 is removed sample storage disk 301, on delivery pipe 410 is transported to sample pallet 204 in the automatic access sluice gate 2.If specimen bottle 305 is put into the sample nest of sample storage disk 301, also take corresponding step, allow the sample nest align with the sample transmission channel, to be placed on the 305 inhale pipes 403 of the specimen bottle on the sample pallet 204 in the automatic access sluice gate 2 by delivery pipe 410, in air intake duct 403 drops into the sample nest of appointment.For guaranteeing that specimen bottle steadily falls into the sample nest, prevent the specimen bottle freely falling body, can lift specimen bottle by lifting air jet pipe 407, allow specimen bottle slow down, lifting the power size will be coupled with specimen bottle weight and position three, should guarantee that specimen bottle enters nest fast, again steady " landing ", this just needs control to lift power with the alternately variation of specimen bottle present position.By the opening degree of Programmable Logic Controller 6 control suction control valves 402 and jet operation valve 408, with this control and suck power with lift power.
Above-mentioned Sample Storehouse 3 is by vertical central shaft, sample storage disk 301 is assembled up layer by layer, the disk driving mechanism makes the original state of disk remain on sample transmission channel up/down perforation state all the time, when needs store certain sample to appointment sample nest, the rotation of driving mechanism driver plate allows this sample nest seek nearest sample transmission channel.Just do not need " exposure " in the environment beyond the storage condition at other sample on the same disk like this, kept well the temperature of sample storage environment.Leave between layers appropriate gap, accomplish the sealing and do not interfere.This structure has solved the sample problem and the sample storage that store as much as possible well in limited space flexible.
If getting the 3rd layer (arranges from bottom to top, the number of plies is greater than 3 layers), certain specimen bottle 11 on the 2nd ring (from inside to outside arranging), then to rotate the sample transmission channel that corresponds to the 2nd ring under the driving of driving mechanism (be unimpeded from the 4th layer to the bottom for the 3rd layer of sample storage disk, first, two layers also is unimpeded, because the sample transmission channel that is every layer is all alignd in virgin state), by lifting the suction with air intake duct 403 of lifting of air jet pipe 407, the sample storage disk 301 that specimen bottle 305 is removed is transported to sample pallet 204 through delivery pipe 310.Then this sample storage disk comes back to original state under the driving of driving mechanism, and namely the sample transmission channel of this layer is alignd with the sample transmission channel of other layer.
Sensor in above-mentioned automatic access sluice gate 2, Sample Storehouse 3, the sample automatic delivering mechanism 4 (Temperature Humidity Sensor, pressure transducer), electric executing part (servomotor, operation valve etc.) all are connected with Programmable Logic Controller 6, move according to condition and order according to the program of Programmable Logic Controller 6 interior establishments.
Fig. 5 has provided the process flow diagram that deposits in of specimen bottle 305, posts in advance the label with bar code on the specimen bottle 305, and a kind of bar code information represents a kind of sample, and each sample nest 302 is corresponding bar code information also, so just forms one-to-one relationship.
First with specimen bottle 305 process automatic access sluice gates 2, enter reefer, barcode scanner 5 carries out bar-code identification, and the bar code information of scanning passed to host computer 7, host computer 7 stores and provides this specimen bottle 305 according to record and deposits position (polar coordinates radius and the polar angle of the number of plies of sample storage disk and sample nest position) at Sample Storehouse 3; Sample Storehouse 3 and sample automatic delivering mechanism start, and the respective sample storage disk in the Sample Storehouse 3 is rotated, and the sample transmission channel of the sample nest above and below that specimen bottle will deposit in is all alignd; Specimen bottle is delivered to air intake duct 403 through delivery pipe 410 simultaneously, enters the sample transmission channel by air intake duct 403.The opening degree of the jet operation valve 408 of Programmable Logic Controller 6 controls, the size of holder for regulating lifting force steadily arrives fast specimen bottle and specifies the sample nest.
The process that specimen bottle 305 takes out is:
Claims (3)
1. a biological medicine sample refrigeration access automatic control system comprises reefer, automatic access sluice gate, Sample Storehouse, sample automatic delivering mechanism, barcode scanner, Programmable Logic Controller and host computer; It is characterized in that: reefer is an obturator, and the automatic access sluice gate is arranged on the reefer sidewall, and Sample Storehouse and sample automatic delivering mechanism all are arranged in the reefer; Barcode scanner is installed in sample and carries on the path of process; Sensor in the automatic access sluice gate is connected execution unit in the Sample Storehouse and the execution unit in the sample automatic delivering mechanism and all is connected with Programmable Logic Controller with execution unit; Barcode scanner and Programmable Logic Controller all are connected with host computer;
The automatic access sluice gate, it is the transition passage that is used for the access sample that reefer and space outerpace contact, be provided with flood tide gate between this transition passage and the external environment condition, and be provided with interior automatically-controlled door between the cold storage environment, be provided with a zone of transition between flood tide gate and the interior automatically-controlled door, be provided with in the zone of transition with the outside gas access that is communicated with of reefer and exhausr port, with cryogenic gas entrance and the protective gas entrance of reefer internal communication, on these mouths valve is installed all; Be provided with pressure transducer and Temperature Humidity Sensor in the zone of transition; The sample pallet of a movement is set in the inboard that interior automatically-controlled door is in reefer, and the inboard of sample pallet is provided with a delivery device;
Sample Storehouse comprises central shaft, sample storage disk and disk driving mechanism; The central shaft bottom is installed on the pedestal, each sample storage disk is installed in parallel on the central shaft, be provided with sealing gasket between the adjacent sample storage disk, be distributed with sample nest and sample transmission channel on the sample storage disk, corresponding to all sample storage disks one cover disk driving mechanism is set at least, the disk driving mechanism is installed on the support that is fixed in pedestal, the sample nest adopts many form of annular rings to be arranged on the sample storage disk, the sample nest is circular distribution, number of rings is at least two rings, all annulus are with one heart, and a sample transmission channel is set on each annulus at least;
The sample automatic delivering mechanism, comprise lifting apparatus and absorption conveying device, lifting apparatus is arranged on the below of bottom sample storage disk, comprise and lift air jet pipe and jet operation valve, arrange one corresponding to each the sample transmission channel on the bottom sample storage disk and lift air jet pipe, lift and be connected with jet operation valve on the air jet pipe, lift air jet pipe and be connected with source of the gas; The absorption conveying device is arranged on the top of top layer sample storage disk, comprise the air-breathing seat of combination, air intake duct, suction control valve, delivery pipe, pipage control valve and vacuum storehouse, corresponding to each the sample transmission channel on the top layer sample storage disk air intake duct is set, be connected with suction control valve on the air intake duct, each air intake duct all is connected with the vacuum storehouse, delivery pipe one end is connected with the vacuum storehouse, and an end is connected to the sample pallet, is connected with the pipage control valve on the delivery pipe.
2. biological medicine sample according to claim 1 refrigerates the access automatic control system, and it is characterized in that: described sample pallet is provided with LOAD CELLS.
3. biological medicine sample according to claim 1 refrigerates the access automatic control system, it is characterized in that: described disk driving mechanism comprises servomotor and gear train, servomotor is connected with the input end of gear train, and the output terminal of gear train is connected on the rotating circular disk.
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| CN 201110167022 CN102269667B (en) | 2011-06-21 | 2011-06-21 | Automatic storing and taking control system for biomedical sample refrigeration |
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| CN 201110167022 CN102269667B (en) | 2011-06-21 | 2011-06-21 | Automatic storing and taking control system for biomedical sample refrigeration |
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| CN106288632A (en) * | 2015-05-15 | 2017-01-04 | 青岛海信医疗设备股份有限公司 | The rendering method of sample in medical treatment refrigerator system |
| CN105737508B (en) * | 2016-01-27 | 2018-11-27 | 青岛海尔科技有限公司 | Medical refrigerator specimen discerning method and device |
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| CN113819699B (en) * | 2021-09-22 | 2022-09-06 | 基点生物科技(成都)有限公司 | Refrigerator for storing biological samples |
| CN113804496A (en) * | 2021-10-12 | 2021-12-17 | 中建西部建设建材科学研究院有限公司 | Intelligent powder sampling device and method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2001285215A1 (en) * | 2000-08-23 | 2002-03-04 | University Of Virginia Patent Foundation | Automated storage and retrieval apparatus for freezers and related method thereof |
| WO2007087546A2 (en) * | 2006-01-23 | 2007-08-02 | Nexus Biosystems, Inc. | Automated system for storing, retreiving and managing samples |
| JP5388282B2 (en) * | 2009-04-17 | 2014-01-15 | 株式会社 東京ウエルズ | Work conveying apparatus and work conveying method |
| CN202166655U (en) * | 2011-06-21 | 2012-03-14 | 山东大学 | Sample automatic access system with function of refrigerating |
-
2011
- 2011-06-21 CN CN 201110167022 patent/CN102269667B/en not_active Expired - Fee Related
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| CN102269667A (en) | 2011-12-07 |
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