CN102100592B - Alginate wound dress material and manufacturing method thereof - Google Patents
Alginate wound dress material and manufacturing method thereof Download PDFInfo
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- CN102100592B CN102100592B CN 200910265956 CN200910265956A CN102100592B CN 102100592 B CN102100592 B CN 102100592B CN 200910265956 CN200910265956 CN 200910265956 CN 200910265956 A CN200910265956 A CN 200910265956A CN 102100592 B CN102100592 B CN 102100592B
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Abstract
The invention discloses an alginate wound dress material, a manufacturing method and a manufacturing device thereof. The wound dress material contains a first fiber layer consisting of a plurality of mutually bonded first fibers and a second fiber layer consisting of a plurality of mutually bonded second fibers, wherein both the first and second fibers are made of alginate. The first fibers are parallel, and the extending direction of the first fibers is roughly parallel to a first direction. The second fibers are parallel, and the extending direction of the second fibers is roughly parallel to a second direction; and the first direction is not parallel to the second direction. The second fiber layer is stacked on the first fiber layer, and the second fibers are bonded with the first fibers. The lengths of the first fibers and the second fibers are proper so that the breaking strength of the wound dress material is more than about 1.5 kilograms force.
Description
Technical field
The relevant a kind of wound of the present invention is applied material, and particularly relevant a kind of alginate wound is applied material.
Background technology
When processing wound, it is generally acknowledged to keep the wound drying can provide wound healing better environment in the past, wound is more easily healed.Therefore in the traditional treatment mode, the soil of mainly avoiding wound to be subjected in external environment with gauze infects, and even keeps wound drying and cleaning.But, in this therapy, wound and wound dressing glutinous situation mutually often can occur, when causing removing wound dressing, be stained with the wound that bonds to firm healing and cause secondary injury to wound.
In recent years, scientist establishes and have the effect that promotes wound healing under moist environment.In the secreted liquid of wound, also find to exist most growth factors (growth factor) that promote wound healings.Therefore establish the scientific evidence that can promote wound healing under moist environment, set up simultaneously the concept of closed coated material.According to this concept, develop several wounds and apply material, wound as materials such as PU film, chitin (chitin)/spherical chitosan (chitosan, or title chitin), collagen protein (collagen) or alginates (alginate) is applied material.
The raw material of alginate is mainly from the Sargassum polysaccharide that extracts in natural seaweed.Alginate wound is in the market applied material and is mainly contained the forms such as adhesive-bonded fabric, film and spongy body (sponge).For example the Kaltostat commodity of Britain BritCair company are that the wound of adhesive-bonded fabric type is applied material.
Yet the alginate wound of above-mentioned adhesive-bonded fabric form is applied material and is existed shortcoming.For instance, when removing the deposited material of wound, the doctor need to carry out the wiping cleaning to wound residual gel and wound fluid with normal saline solution.The alginate wound of adhesive-bonded fabric form is applied material and easily produce the situation of fracture when being cleaned.On the other hand, on adhesive-bonded fabric, the alginate fiber of short fiber easily comes off, and is stained with to stick on wound and form short flannel, causes wound to be difficult for healing.
In view of this, need a kind of new alginate wound to apply material, it can be avoided the alginate wound to apply the material fracture when removal and form the problem such as short flannel on wound, to promote wound healing, the convenient use.
Summary of the invention
The wound that the objective of the invention is to propose a kind of new alginate is applied material, and the alginate wound that can solve traditional adhesive-bonded fabric type is applied the problems such as material short flannel and fracture.Traditional alginate wound is applied material from the wound during removal, can produce fracture or be stained with glutinous wound and form the reason of the problems such as short flannel, is mainly because traditional alginate wound is applied due to the undercapacity of material.
In view of this, the present invention proposes a kind of new wound and applies material, and it mainly comprises the formed long fibre of alginate.By the length of fiber and the arrangement mode of fiber, improve intensity, particularly fracture strength that wound is applied material.
According to an aspect of the present invention, wound is applied material and is comprised at least two fibre layers, the first fibrous layer by several cohere mutually first fibrous, the second fibrous layer is second fibrous by several mutual gluings, wherein the material of the first fiber and the second fiber is alginate.Alginate can be calcium alginate, barium alginate, copper alginate, alginic acid zinc, alginic acid silver or ferric alginate.
Wound is applied the arrangement mode of the first and second fibers of material, and the fracture strength that makes wound apply material improves.Specifically, the first fiber in the first fibrous layer side by side and extend and be roughly parallel to first direction.The second fiber in the second fibrous layer side by side and extend and be roughly parallel to second direction, wherein first direction is not parallel to second direction.In an optional embodiment, first direction and second direction are orthogonal.
The second fibrous layer is stacked on the first fibrous layer, and the second fiber coheres the first fiber.In an embodiment of the present invention, the first fiber and the second fiber only cohere and do not weave, and meaning i.e. the first fiber and the winding mutually of the second fiber.
The first fiber and the second fiber are long fine.Specifically, the length of the first fiber and the second fiber is suitable length, makes wound apply the fracture strength of material greater than 1.5 kgfs.According to optional embodiment, the fracture strength that wound is applied material is that 100 kgfs are to approximately between 109 kgfs.In embodiments of the present invention, above-mentioned suitable length refers to that the length of the first fiber and the second fiber is respectively approximately between 5 centimetres to 20 centimetres.
Hence one can see that, wound is applied material and is had long the first and second fine fibers, and by the arrangement mode of the first fiber and the second fiber, make wound apply the fracture strength of material all directions, especially the fracture strength along the bearing of trend of the first fiber and the second fiber is improved.
The manufacture method that the present invention provides a kind of wound to apply material on the other hand, the wound that has the alginate of high fracture strength in order to manufacturing is applied material.First step that wound is applied the manufacture method of material is to carry out a wet type spinning process, to form at least one alginate fiber.Then, be wound around alginate fiber in plate, to form several first fibers on a surface of plate.Lip-deep the first fiber at plate is arranged side by side mutually, and roughly extension is parallel to first direction.
Then, again be wound around alginate fiber on plate, to form several second fiber stack on the first fiber on plate.Wherein, the second fiber is arranged side by side mutually, and roughly extension is parallel to second direction, the not parallel first direction of second direction.
Between the step of twice winding alginate fiber, rotatable plate.By this, the front and back bearing of trend that is wound in the alginate fiber on plate for twice is not parallel to each other.Specifically, the anglec of rotation of plate is the angle of cut between first direction and second direction.
In an embodiment of the present invention, after carrying out the step that is wound around alginate fiber, after for example being wound around for the first time the step of alginate fiber or after being wound around once again the step of alginate fiber, can spray the surface of the alginate fiber of sodium ion aqueous solution after being wound around, make the surface of alginate fiber omit micro dissolution or softening.After its dry tack free, the alginate fiber of winding can cohere mutually.Thus, the first fiber that is wound on plate can cohere mutually, and the second fiber also can cohere mutually.Alternatively, the first fiber and the second fiber also can cohere mutually.
In a plurality of embodiment of the present invention, alginate is optionally calcium alginate, barium alginate, copper alginate, alginic acid zinc, alginic acid silver or ferric alginate.
In an embodiment of the present invention, the sodium ion aqueous solution is sodium-chloride water solution, and the concentration of its sodium chloride can be adjusted according to circumstances.In one embodiment of this invention, the concentration expressed in percentage by weight of the sodium chloride in the sodium ion aqueous solution is approximately 1% to arrive approximately between 15%.
According to optional embodiment, after the step of carrying out the wet type spinning process, can carry out drafting process, it is to use drawing rollers drawing-off alginate fiber, to adjust the thread breakage intensity of alginate fiber.
Another aspect of the invention provides a kind of wound to apply the material producing device, applies material in order to make the alginate wound.Wound is applied the material producing device and is comprised and batch device, and it is in order to batch fiber.Batching utensil has the rotating shaft of a connecting motor, and rotating shaft is arranged on pedestal.One plate locking is in rotating shaft.By the driving of motor, make plate rotate with respect to pedestal centered by rotating shaft, and then fiber roll is taken on plate.
Wound is applied the material producing device and is had a reciprocating apparatus, before it is arranged on and batches device, with so that fiber distribute onboard fifty-fifty.Reciprocating apparatus has a through wires hole and passes for fiber.The reciprocating apparatus pedestal that is slidably connected reciprocatingly slides in order to the axial path that is parallel to rotating shaft along.Thus, when fiber roll was got onboard, fiber was driven by reciprocating apparatus and moves along the direction of principal axis of rotating shaft, and then on average batches on plate.
Wound is applied the material producing device and is had a tension regulator, before it is arranged on and batches device.Tension regulator connects fiber, keeps stable in order to regulate and control the tension force of fiber in coiling process, to make the tension force that batches the fiber of locating at the surface of plate or the edge of plate etc.Be slidably connected pedestal and couple rotating shaft of tension regulator.When plate rotated, tension regulator slided because rotating shaft drives, and then changed the relative position between itself and plate.By changing the relative position between tension regulator and plate, with the tension force of the fiber between retaining plate and tension regulator.
In optional embodiment, the length of chute is less than the twice of rotating shaft to the distance at the edge of plate.
According to another optional embodiment, tension regulator couples rotating shaft, reciprocatingly slides along chute driven by rotating shaft.
The another kind of optional embodiment that wound is applied the producing device of material has also comprised at least one cam, is connected in the mentioned strain actuator.Another optional embodiment that wound is applied the producing device of material has also comprised at least one banded structure, is connected in rotating shaft.Another embodiment that wound is applied the producing device of material also comprises fixture, is connected in rotating shaft, in order to lock or to unclamp this plate
The embodiment that another kind of optional wound is applied the producing device of material also comprises reciprocating apparatus, and this pedestal that is slidably connected is in order to connect this fiber and to reciprocatingly slide along an axial path that is parallel to this rotating shaft.In one embodiment, above-mentioned reciprocating apparatus comprises hole, screw rod and actuator.Pedestal is run through in above-mentioned hole; Screw rod passes this hole; And actuator makes an end of this screw rod change to the spacing between this hole in order to promote this screw rod.In another optional embodiment, reciprocating apparatus also comprises through wires hole, is positioned on this screw rod, passes for this fiber.
Comprehensively above-mentioned, the present invention proposes a kind of wound of alginate and applies the deposited material producing device of material, its manufacture method and wound.Wound is applied material and is had formed the first and second fibers of alginate, and two fibers extend respectively different directions.By arrangement mode and the length of the first fiber and the second fiber, the fracture strength that makes wound apply material is improved.
Description of drawings
For above and other objects of the present invention, feature, advantage and embodiment can be become apparent, below in conjunction with accompanying drawing, preferred embodiment of the present invention is described, wherein:
Figure 1A illustrates the schematic diagram that applies material according to the wound of one embodiment of the invention.
Figure 1B is the photo that the wound of one embodiment of the invention is applied material.
Fig. 2 illustrates the flow chart that applies the manufacture method of material according to the wound of another embodiment of the present invention.
Fig. 3 A illustrates respectively the operation schematic diagram that applies material according to the wound of another embodiment of the present invention to Fig. 3 F.
Fig. 4 illustrates the front elevational schematic of applying the material producing device according to the wound of one embodiment of the invention.
Fig. 5 A and Fig. 5 B illustrate respectively the different operating states of the deposited material producing device of wound of Fig. 4.
Fig. 6 A to Fig. 6 C illustrates respectively the schematic rear view of the deposited material producing device of wound of different embodiments of the invention.
Fig. 7 is the part enlarged diagram that illustrates the deposited material producing device of wound of Fig. 4.
Fig. 8 A and Fig. 8 B are the profile along the hatching line 8 of Fig. 4, and it represents respectively the different operating states of reciprocating apparatus.
The specific embodiment
Please refer to Figure 1A and Figure 1B, Figure 1A illustrates the schematic diagram that applies material 100 according to the wound of one embodiment of the invention, and Figure 1B is the photo that the wound of one embodiment of the invention is applied material 100.
The wound that embodiments of the invention propose is applied material 100, it mainly comprises the formed fiber of alginate, by the length of fiber and the arrangement mode of fiber, improve wound and apply the fracture strength (breakingstrength) of material 100, apply material from the wound during removal with the alginate wound of avoiding traditional adhesive-bonded fabric type, institute produces to rupture or be stained with and sticks wound and form the problem such as short flannel.
Herein, when fracture strength refers to that wound is applied the material fracture, put on the power on the deposited material of wound, the unit that uses is kgf (kgf).In the following embodiments, utilize the standard A STM D3822-2007 of American Society Testing and Materials (Standard Test Method for Tensile Properties of Single Textile Fibers) to measure the fracture strength that wound is applied material 100.
Wound is applied material 100 and is comprised at least two fibre layers, and it is respectively the first fibrous layer 110 and the second fibrous layer 120.Fiber in two fibre layers is the long fiber of length.By length and the arrangement mode of fiber in the first fibrous layer 110 and the second fibrous layer 120, the fracture strength that makes wound apply material 100 improves.Deposited material 100 each assemblies of wound and characteristic thereof are described in detail as follows with that.
The first fibrous layer 110 is comprised of the first fiber 112 that several cohere mutually.The material of the first fiber 112 is alginate.The first fiber 112 is arranged side by side each other, and extends and to be roughly parallel to same direction, hereinafter referred to as first direction 130.
The second fibrous layer 120 is stacked on the first fibrous layer 110.The second fibrous layer 120 is comprised of the second fiber 122 of several mutual gluings.The material of the second fiber 122 is also alginate.The second fiber 122 is arranged side by side each other, and extends and to be roughly parallel to same direction, and hereinafter referred to as second direction 132, wherein first direction 130 is not parallel to second direction 132.
In an embodiment of the present invention, when the second fibrous layer 120 was stacked on the first fibrous layer 110, the second fiber 122 was to cohere on the first fiber 112 with smooth kenel.In other words, the first fiber 112 and the second fiber 122 only cohere and do not weave, and meaning i.e. the first fiber 112 and the winding mutually of the second fiber 122.
The first fiber 112 and the second fiber 122 are made by alginate, and its raw material is mainly from extracting in natural seaweed.The ancient sieve hyaluronic acid of two composition β in the alginic acid molecule-D-manna hyaluronic acid (β-D-mannuronic acid) and α-L-(α-L-guluronic acid) is distributed in its macromolecular chain with irregular putting in order, mainly with the β that replaces-D-manna hyaluronic acid and the ancient sieve hyaluronic acid of α-L-or poly alternately [the ancient sieve hyaluronic acid of β-D-manna hyaluronic acid and α-L-] n be connected.In an embodiment of the present invention, alginate can be calcium alginate, barium alginate, copper alginate, alginic acid zinc, alginic acid silver or ferric alginate.
In an embodiment of the present invention, the first fiber 112 and the second fiber 122 all cohere mutually, use to promote the fracture strength that wound is applied material 100.When making, can at the fiber of the in type alginate surface sprinkling sodium ion aqueous solution as the first fiber 112, make slightly micro dissolution or softening of its surface, and produce mucus, to bind wantonly two the first adjacent fibers 112.After the mucus drying, the first fiber 112 just can cohere mutually.The second fiber 122 also can cohere mutually by said method.Further, can be at the surface sprinkling sodium ion aqueous solution of the first fibrous layer 110, then the second fibrous layer 120 is stacked on the first fibrous layer 110.By this, the first fiber 112 just can cohere with the second fiber 122.
Sodium ion aqueous solution 320 can be the aqueous solution that comprises sodium chloride, and the concentration of the sodium chloride in aqueous solution can be adjusted according to circumstances.In one embodiment of this invention, the concentration expressed in percentage by weight of the sodium chloride in the sodium ion aqueous solution is approximately 1% to approximately between 15%, for example approximately 1,, 3,4,5,, 7,8,9,10,11,12,13,14 or 15%.In optional embodiment of the present invention, the concentration expressed in percentage by weight of sodium chloride is approximately 10%.For instance, in preparation hereinafter during the 1st described embodiment of form, just utilized concentration expressed in percentage by weight to be about 10% sodium-chloride water solution.
Utilize existing wet spinning to copy in conjunction with water fracture strength that the prepared sodium alginate wound of short fiber adhesive-bonded fabric technology applies material and be about 1.493kgf.This fracture strength often is not enough to prevaricate applied force when removing the deposited material of wound, thereby causes applying the problems such as material fracture and short flannel formation.Therefore, according to principle of the present invention and spirit, the length long enough of the first fiber 112 and the second fiber 122 is so that wound is applied the fracture strength of material 100 greater than 1.5 kgfs.
According to the embodiment of the present invention, the first fiber 112 and the second fiber 122 are long fine, and its length is all greater than approximately 1 centimetre.In this kind situation, wound is applied the fracture strength of material 100 greater than 1.5 kgfs.
Well known, in a suitable scope, the length of fiber is longer, and the line strength of fiber is also larger.Line strength described herein refers to the tension force of fiber.The line strength of the first fiber 112 and the second fiber 122 is larger, and the fracture strength that wound is applied material 100 is larger.
In an embodiment of the present invention, be to select three groups of wounds with length of different the first fibers 112 and the second fiber 122 to apply material 100, carry out the fracture strength test.Three form wound applies material 100 and all carries out fracture strength with SMI and identical draw speed and test.Acquired results is as shown in the 1st form.The length of the first fiber 112 and the second fiber 122 is enough to make wound to apply the fracture strength of material 100 between being about 107 kgfs to approximately between 109 kgfs.
| The length of the first fiber (unit: centimetre) | The length of the second fiber (unit: centimetre) | Fracture strength (unit: kgf) |
| 5 | 7 | 108.339 |
| 10 | 12 | 107.773 |
| 15 | 20 | 108.813 |
[0054]The 1st form
Therefore, according to a plurality of embodiment, the length long enough of the first fiber 112 and the second fiber 122 so that wound apply the fracture strength of material 100 be approximately 100 kgfs to approximately between 109 kgfs, about 100,101,102,103,104,105,106,107,108 or 109 kgfs for example.
By the listed embodiment of the 1st form as can be known, want to reach above-mentioned fracture strength, the length of the first fiber 112 and the second fiber 122 is respectively approximately 5 centimetres to approximately between 20 centimetres, for example approximately 5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 or 20 centimetres.
In addition, in the 1st described embodiment of form, the length of the first fiber 112 approximates or is slightly less than the width that wound is applied material 100, and the length of the second fiber 122 approximates or be slightly less than the length that wound is applied material 100.Certainly, in other embodiment of the present invention, also can use this kind configuration mode.
The bearing of trend of the first fiber 112 is parallel to 122 extensions of first direction 130, the second fiber and is parallel to second direction 132, two directions and is not parallel to each other.In other words, between first direction 130 and second direction 132, an angle is arranged, the angle angle between 0 the degree to 180 the degree between, for example approximately 5,10,15,20,25,30,35,40,45,50,55,60,65,70,75,80,85,90,95,100,105,110,115,120,125,130,135,140,145,150,155,160,165,170,175 or 180 the degree.According to optional embodiment of the present invention, first direction 130 is approximately perpendicular to second direction 132.For instance, in each embodiment described in the 1st form, first direction 130 is approximately perpendicular to second direction 132.
Hence one can see that, and wound is applied material 100 by length and the arrangement mode of its first fiber 112 and the second fiber 122, makes wound apply the fracture strength of material 100 all directions, and especially the fracture strength along first direction 130 and second direction 132 is improved.
Note that in an embodiment of the present invention, apply material 100 as an illustration though propose to have the wound of two fibre layers, however in fact wound apply the fibrolaminar number of plies that material 100 can have can be two-layer more than, for example 3,4,5 layers or more multi-layered.The bearing of trend of the fiber of the bearing of trend of the fiber in its each layer fibrous layer in can not parallel other fibrous layer.
Fig. 2 illustrates the flow chart that applies the manufacture method 200 of material 100 according to the wound of one embodiment of the invention.Fig. 3 A illustrates respectively the operation schematic diagram that applies material 100 according to the wound of one embodiment of the invention to Fig. 3 D.
Please refer to Fig. 2 and Fig. 3 A.First step 210 that wound is applied the manufacture method 200 of material 100 is the formation alginate fiber.It can form at least one alginate fiber 310 by carrying out a wet type spinning process.Specifically, the wet type spinning process is the sodium alginate salt compounds to be dissolved in make the spinning mucus in aqueous solution, again with the spinning mucus by spin mouth hole extrusion molding in the forming tank that contains divalent metal, form the alginate fiber 310 of solid-state insolubility.In an embodiment of the present invention, alginate can be calcium alginate, barium alginate, copper alginate, alginic acid zinc, alginic acid silver or ferric alginate.
Alternatively, after forming alginate fiber 310, then can extend alginate fiber 310 by drafting process, to adjust the thread breakage intensity of alginate fiber 310.Drafting process can be carried out by the drawing rollers group.The structure of drawing rollers and the method for drawn fiber are to have in the art knows that usually the knowledgeable knows, and no longer adds to give unnecessary details at this.
Step 220 is for being wound around alginate fiber 310 on a plate 300.After being wound around, alginate fiber 310 is understood a section ground and is listed on a surface of plate 300.At this, will be called the first fiber 112 at the lip-deep multistage alginate fiber 310 of plate 300.The length of the first fiber 112 approximates or is slightly less than the length of plate 300.In an embodiment of the present invention, the length of each first fiber 112 is respectively 5 centimetres to approximately between 20 centimetres, for example approximately 5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 or 20 centimetres.
Please also refer to Fig. 2 and Fig. 3 B.After being wound around alginate fiber 310, but execution in step 230, the surface of spraying the alginate fiber 310 of sodium ion aqueous solution 320 after being wound around.At the surface sprinkling sodium ion aqueous solution 320 of in type alginate fiber 310, can make the surface of alginate fiber 310 omit micro dissolution or softening, and produce mucus.After the mucus drying, adjacent alginate fiber 310 just can cohere mutually.
Sodium ion aqueous solution 320 can be the aqueous solution that comprises sodium chloride, and the concentration of the sodium chloride in aqueous solution can be adjusted according to circumstances.In one embodiment of this invention, the concentration expressed in percentage by weight of the sodium chloride in the sodium ion aqueous solution is 1% to approximately between 15%, for example approximately 1,, 3,4,5,, 7,8,9,10,11,12,13,14 or 15%.In an embodiment of the present invention, the concentration expressed in percentage by weight of sodium chloride is approximately 10%.
Please also refer to Fig. 2, Fig. 3 C and Fig. 3 D.After completing winding first, first with plate 300 rotations, as shown in Figure 3 C.Then, execution in step 240 is wound around alginate fiber 310 on plate 300, again as shown in Fig. 3 D.Alginate fiber 310 is understood a section ground and is listed on the surface of plate 300 after being wound around, and is referred to as the second fiber 122 at this.The length of the second fiber 112 approximates or is slightly less than the length of plate 300.In an embodiment of the present invention, the length of each second fiber 112 be 5 centimetres to approximately between 20 centimetres, for example approximately 5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 or 20 centimetres.
The second fiber 122 is stacked in the first fiber 112 that is positioned in winding working procedure last time on plate 300.Note that due between twice winding working procedure, can be with plate 300 rotation, make the bearing of trend of the first fiber 112 be not parallel to the bearing of trend of the second fiber 122.In other words, the anglec of rotation of plate 300 is the angle of cut between the bearing of trend of the bearing of trend of the first fiber 112 and the second fiber 122.As illustration and unrestricted, the anglec of rotation of plate 300 between 0 the degree to 180 the degree between, for example approximately 5,10,15,20,25,30,35,40,45,50,55,60,65,70,75,80,85,90,95,100,105,110,115,120,125,130,135,140,145,150,155,160,165,170,175 or 180 the degree.In an embodiment of the present invention, the anglec of rotation of plate 300 be approximately 90 the degree.
Please refer to Fig. 2, Fig. 3 E and Fig. 3 F.After winding is completed, cut wound along the edge of plate 300 and apply material 100, and wound is applied on material 100 slave plates 300 take off, as shown in Fig. 3 F.
Then, execution in step 250 is with dry alginate fiber.As previously mentioned, the surface sprinkling sodium ion aqueous solution 320 due in type alginate fiber 310 can produce mucus.After the mucus drying, adjacent alginate fiber 310 can be cohered mutually.
In an embodiment of the present invention, be to adopt the lyophilization operation to come dry alginate fiber 310.Cryodesiccated method has a variety of, and also visual actual operation situation and adjusting of its freezing temperature and pressure.In an embodiment of the present invention, cryodesiccated temperature is to adopt between-20 degree approximately Celsius are spent to approximately-55, and pressure is to set to be about 12 handkerchiefs.
Note that in an embodiment of the present invention, though each step is sequentially illustrated, in fact step order can change, and the number of times that step is carried out also can be repeatedly.For instance, spraying the step of sodium ion aqueous solution 320 and the step of winding alginate fiber 310 etc. can repeatedly carry out.
The step of in addition, spraying the sodium ion aqueous solution is not limited to the step (step 220) that is wound around first alginate fiber 310 and carries out afterwards.The step of in fact spraying the sodium ion aqueous solution can be when being wound around alginate fiber 310 (step 220) and carrying out first, be wound around alginate fiber 310 first after, wait each execution in the same time when again being wound around alginate fiber 310 (step 240) and carrying out or after again being wound around alginate fiber 310.
Please refer to Fig. 4, its illustrate according to one embodiment of the invention in order to make as the schematic diagram of the producing device 400 of the deposited material 100 of wound that Figure 1A illustrates.Producing device 400 has pedestal 410, batches device 420 and tension regulator 430.Batch device 420 in order to batch alginate fiber 310.Batch device 420 and comprise rotating shaft 422 and plate 300, wherein plate 300 is locked in rotating shaft 422.When rotating shaft 422 is driven and when rotating, during for example along direction 402 rotation, alginate fiber 310 can batch on plate 300.
The scroll bar that is different from the traditional round tubular due to the shape of plate 300, when batching, the change of the length of alginate fiber 310 excessively causes the tension change of alginate fiber 310 during batch, one tension regulator 430 was arranged, to keep the tension force of alginate fiber 310 before batching device 420.
Specifically, a chute 412 is arranged on pedestal 410, be positioned at rotating shaft 422 other.The centre position of rotating shaft 422 alignment chutes 412.Tension regulator 430 is arranged in chute 412, and slides along the bearing of trend of chute 412.
Thus, dwindle to the length variations of the alginate fiber 310 between the edge 302 or 304 of plate 300 between tension regulator 430, to keep the tension stability of alginate fiber 310.
Note that in an embodiment of the present invention, the length of chute 412 is without limiting.For instance, when the edge 302 or 304 of plate 300 forwarded highest point to, it can be higher or lower than an end higher on chute 412.When the edge 302 or 304 of plate 300 forwarded lowest part to, it can be higher or lower than an end lower on chute 412.In one embodiment of this invention, when the edge 304 of plate 300 forwards highest point to, the higher end centre of edge 304 and rotating shaft 422 of approximately aliging on chute 412.When the edge 304 of plate 300 forwards lowest part to, the lower end centre of edge 304 and rotating shaft 422 of approximately aliging on chute 412.In an embodiment of the present invention, the length of chute 412 can be less than rotating shaft 422 to the twice of the distance at the edge 304 of plate 300 or one times.
Alternatively, tension regulator 430 can couple rotating shaft 422, for example by gear, screw rod, belt, cam, trace or other mechanical component connection rotating shaft 422.Drive and reciprocatingly slide along chute 412 by rotating shaft 422.
For instance, please refer to Fig. 6 A, it illustrates the schematic rear view of the producing device 400 of one embodiment of the invention.Producing device 400 is provided with cam 431, bar 432 and banded structure 433 as belt.Banded structure 433 connection rotating shafts 422 and cam 431.One end of bar 432 connects tension regulator 430, other end butt cam 431.When rotating shaft 422 is driven and when rotating along direction 404, it rotates along direction 406 by banded structure 433 band moving cams 431.Due to the setting of cam 431 and bar 432, cam 431 meeting catch bars 432 and tension regulator 430 slide along chute 412.
The schematic rear view of the producing device 400 of Fig. 6 another embodiment of the present invention that B illustrates for example again.Rotating shaft 422 is to drive tension regulator 430 by trace 434.Specifically, producing device 400 is provided with trace 434 as crank 435 and rocking bar 436.Banded structure 433 is as belt connection rotating shaft 422 and crank 435.One end of rocking bar 436 connects tension regulator 430, other end pivot joint crank 435.When rotating shaft 422 was rotated along direction 404, it drove crank 435 along direction 406 rotations and then drives rocking bar 436 by banded structure 433 and swings, and makes tension regulator 430 reciprocatingly slide along chute 412.
The schematic rear view of the producing device 400 of Fig. 6 another embodiment of the present invention that C illustrates for example again.Rotating shaft 422 is to drive tension regulator 430 by trace 434.Specifically, producing device 400 is provided with trace 434 as wheel 437 and rocking bar 436.Wherein the two ends of rocking bar 436 difference pivot joint wheel 437 is near circumference place and tension regulators 430.Banded structure 433 is as belt connection rotating shaft 422 and wheel 437.When rotating shaft 422 was rotated along direction 404, it rotated along direction 406 by banded structure 433 driven wheels 437, and then drives rocking bar 436 swings, makes tension regulator 430 reciprocatingly slide along chute 412.
In the above-described embodiments, be to utilize banded structure 433 as connecting.Alternatively, banded structure 433 also can change gear train into, is used as the connection between rotating shaft 422 and tension regulator 430.
By the various embodiments described above as can be known, tension regulator 430 can be by as cam 431, trace 434 and various possible mechanical component connection rotating shaft 422, with the synchronizing moving along with the rotation of rotating shaft 422.
Alternatively, also can rotate to detect it by be electrically connected rotating shaft 422 as automatic control module, and be adjusted to the position of tension regulator 430 according to testing result.
A variety of in order to plate 300 locking is had at the fixture 424 of rotating shaft 422, such as elastic clip, C clamp or its combination etc.Please refer to Fig. 7, it illustrates the part enlarged diagram of the producing device 400 of one embodiment of the invention.In an embodiment of the present invention, fixture 424 has a holder 426 and a screw 428.Holder 426 is fixed in rotating shaft 422, can be placed in wherein for the part of plate 300.Screw 428 is locked in holder 426, so that plate 300 is locked in holder 426.During the wish dismounting, screw 428 can be unclamped, just plate 300 can be taken off in holder 426.
Be stained with glutinously for fear of alginate fiber 310 and plate 300, the material of plate 300 be the material of not reacting with alginate, and its smooth surface.In an embodiment of the present invention, the material of plate 300 can be acrylic resin (acrylicresin).It is required and change that the shape of plate 300 can be looked closely product, as square, rectangle, rhombus, polygon or circular etc.
Please refer to Fig. 4.In order to make in coiling process, alginate fiber 310 is distributed on plate 300 fifty-fifty, and producing device 400 can be provided with reciprocating apparatus 440 before batching device 420, is used for driving alginate fiber 310 and moves back and forth along the direction of principal axis that is parallel to rotating shaft 422.
Specifically, please also refer to Fig. 4, Fig. 8 A and Fig. 8 B, Fig. 8 A and Fig. 8 B are the profile of the hatching line 8 of Fig. 4, and it illustrates respectively the different operating state of reciprocating apparatus 440.
In one embodiment of this invention, on bar 442, screw thread is arranged, the screw thread on its mating holes 414.Actuator 444 can be used to dwang 442, and bar 442 is moved back and forth along its bearing of trend.Alternatively, actuator 444 can be linear-motion actuator, and directly catch bar 442 moves back and forth along its bearing of trend.
Note that to drive the reciprocating structure of alginate fiber 310 has a variety ofly, and propose an embodiment at this and only be used as explanation, be not to limit the scope of the invention.
In an embodiment of the present invention, producing device 400 can include a wet type spinning assembly 450, and it forms alginate fiber 310 in order to carry out a wet type spinning process.The detailed step of wet type spinning process has described in detail as above, does not repeat them here.
In order to strengthen the tension force of alginate fiber 310, producing device 400 can further be provided with drawing rollers assembly 460.Drawing rollers assembly 460 is in order to drawing-off alginate fiber 310, to adjust the thread breakage intensity of alginate fiber 310.
By above-mentioned each embodiment as can be known, the present invention's wound of proposing a kind of alginate apply material 100, its manufacture method with and producing device 400.As shown in Figure 1A, wound is applied material 100 and is had the structure of multi-layer fiber layer, and all fibres in each fibrous layer roughly extends same direction, and different fibrolaminar bearing of trends are not quite similar.Fiber in each fibrous layer is long fine.By length and the arrangement mode of fiber in each fibrous layer, the fracture strength that makes wound apply material 100 is improved, and then avoids wound to apply material 100 producing fracture during removal from the wound or be stained with the problem such as glutinous wound.
Although the present invention discloses as above with embodiment; yet it is not to limit the present invention; anyly be familiar with this operator; without departing from the spirit and scope of the present invention; when can make the various changes that are equal to or replacement, so protection scope of the present invention is when looking accompanying being as the criterion that the application's claim scope defines.
Claims (10)
1. a wound is applied material, comprises at least:
One first fibrous layer is that the material of these the first fibers is an alginate by a plurality of first fibrous, and these first fibers cohere mutually, and these first fibers side by side and extend and be roughly parallel to a first direction; And
One second fibrous layer is that the material of these the second fibers is an alginate by a plurality of second fibrous, the mutual gluing of these the second fibers, these second fibers side by side and extend and be roughly parallel to a second direction, wherein this first direction is not parallel to this second direction
Wherein this second fibrous layer is stacked on this first fibrous layer, and these second fibers cohere these the first fibers,
Wherein the length of these first fibers and these the second fibers makes this wound apply the fracture strength of material greater than 1.5 kgfs.
2. wound according to claim 1 is applied material, it is characterized in that, this alginate is calcium alginate, barium alginate, copper alginate, alginic acid zinc, alginic acid silver or ferric alginate.
3. wound according to claim 1 is applied material, it is characterized in that, the fracture strength that the length of these first fibers and these the second fibers makes this wound apply material is that 100 kgfs are between 109 kgfs.
4. wound according to claim 1 is applied material, it is characterized in that, the length of each this first fiber is between 5 centimetres to 20 centimetres, and the length of each this second fiber is between 5 centimetres to 20 centimetres.
5. wound according to claim 1 is applied material, it is characterized in that, this first direction is perpendicular to this second direction.
6. a wound is applied the manufacture method of material, comprises at least:
Carry out a wet type spinning process and form at least one alginate fiber;
Be wound around this alginate fiber in a plate, to form a plurality of the first fibers on a surface of this plate, wherein these first fibers side by side and roughly extend and are parallel to a first direction;
Spray the surface of this alginate fiber of a sodium ion aqueous solution after being wound around;
Again be wound around this alginate fiber on this plate, to form a plurality of the second fiber stack on these first fibers, wherein these second fibers side by side and roughly extend and are parallel to a second direction, not parallel this first direction of this second direction; And
Dry these first fibers and these second fibers make these first fibers and these second fibers cohere mutually.
7. wound according to claim 6 is applied the manufacture method of material, it is characterized in that, this sodium ion aqueous solution comprises sodium chloride, and the concentration expressed in percentage by weight of the sodium chloride in this sodium ion aqueous solution is between 1% to 15%.
8. wound according to claim 6 is applied the manufacture method of material, it is characterized in that, the composition of this alginate fiber is calcium alginate, barium alginate, copper alginate, alginic acid zinc, alginic acid silver or ferric alginate.
9. wound according to claim 6 is applied the manufacture method of material, it is characterized in that, also comprises before the step that again is wound around this alginate fiber:
Rotate this plate, wherein the anglec of rotation of this plate is the angle of cut between this first direction and this second direction.
10. wound according to claim 6 is applied the manufacture method of material, it is characterized in that, after the step of carrying out this wet type spinning process, also comprises:
By at least one this alginate fiber of drawing rollers drawing-off, to adjust the thread breakage intensity of this alginate fiber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910265956 CN102100592B (en) | 2009-12-21 | 2009-12-21 | Alginate wound dress material and manufacturing method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200910265956 CN102100592B (en) | 2009-12-21 | 2009-12-21 | Alginate wound dress material and manufacturing method thereof |
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| CN201310119490.2A Division CN103211681B (en) | 2009-12-21 | 2009-12-21 | Alginate wound dressing as well as manufacture method and manufacture device of alginate wound dressing |
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| CN102100592B true CN102100592B (en) | 2013-05-22 |
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| US7601525B2 (en) * | 2004-03-05 | 2009-10-13 | University Of Florida Research Foundation, Inc. | Alginate gel scaffold having a plurality of continuous parallel microtubular copper capillaries |
| US8591584B2 (en) * | 2007-11-19 | 2013-11-26 | Nuvasive, Inc. | Textile-based plate implant and related methods |
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