CN102085159B - Nursing type disinfecting liquid soap - Google Patents
Nursing type disinfecting liquid soap Download PDFInfo
- Publication number
- CN102085159B CN102085159B CN 201110025453 CN201110025453A CN102085159B CN 102085159 B CN102085159 B CN 102085159B CN 201110025453 CN201110025453 CN 201110025453 CN 201110025453 A CN201110025453 A CN 201110025453A CN 102085159 B CN102085159 B CN 102085159B
- Authority
- CN
- China
- Prior art keywords
- disinfection liquid
- handwashing disinfection
- nursing
- disinfectant
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to nursing type disinfecting liquid soap which is a water solution containing the following components in proportion by weight: 0.1-5.0% of disinfectant, 1.0-30.0% of surfactant, 0.5-40.0% of thickener, 0.1-25.0% of nursing agent, 0.05-2.0% of pH regulator for regulating the pH of the solution to be 5-7, and 0.0-30.0% of lipophilic solvent. The nursing type disinfecting liquid soap provided by the invention has a homogeneous formula and a very low content of alcohol components, and skin protecting factors are added, thus reducing skin dryness or cracking and irritant dermatitis caused by frequent hand washing, and achieving multiple effects of washing, disinfecting and protecting skin. Therefore, the nursing type disinfecting liquid soap is a novel mild hand washing disinfectant with an efficient disinfecting action.
Description
Technical field
The present invention relates to the sanitary washing sterile products.
Background technology
Antibacterial, virus, parasitic ovum and some nuisance mass-energy enlarge as intermediary with hands to be propagated, and washing one's hands is important measures of infection prevention, keeps the health of hands to be considered to a hands disinfectant part.The chance of the public contacts of modern society people increases; Also increasing through the catch an illness chance of bacterium of feel; Especially medical personnel, in to patient's diagnosis and treatment, nursing, health check-up and work such as change dressings, handle cause directly and the courses of infection of indirect occupy the first place.Therefore, holding this pass of washing one's hands and be guaranteeing healthy important means, also is the control disease effective method of propagating and protect from infection.
Hand-washing article belongs to a kind of of skin cleaner, goes over very long one period in China, and people use fertilizer (perfume (or spice)) soap to wash one's hands always.Fertile (perfume (or spice)) is prone to landing in use though soap has good dirt-removing power, and chance water and high temperature can soften and consume naturally; And be alkalescence, can make xerosis cutis, tarnish after washing; Especially be prone to be infected with on hand dirt and antibacterial, become the secondary pollution source.The transformation of mass consumption idea makes handwashing disinfection liquid become the succedaneum of traditional hand-washing article in recent years gradually.Handwashing disinfection liquid has performance gentleness, not chafe, hard water easy to use, anti-, easy cleaning, foam is abundant and wash characteristics such as back skin lubrication sense is good, and sanitation and hygiene, is easy to deposit.Especially adopt the bottle pump head squash type amount of getting, the cross infection when having avoided different crowd to use, thereby receive consumers in general's popular welcome.Also there has been higher expectation in consumer to handwashing disinfection liquid, and common handwashing disinfection liquid only has the basic function of cleaning hand dirt, can not satisfy consumer hope its have the requirement of more function property, as comprise sterilization, purposes such as antibacterial.Particularly 2003, after China's some areas outburst SARS virus, broad masses just called forwardly and develop disinfecting, antimicrobial handwashing disinfection liquid on the market as early as possible, can not only clean decontamination, can also antibiotic and sterilizing.
At present, in the functional handwashing disinfection liquid that China sells, the sterilization series products has become a type of sales volume maximum.Civilized, healthy modern way of life is recognized increasing consumer, and the use of handwashing disinfection liquid has become a requisite important component part in the healthy living.But the exploitation of China's handwashing disinfection liquid and production still are in the starting stage at present; The exploitation of handwashing disinfection liquid product need be used the scientific and technological achievement of a plurality of fields such as medical treatment, medicine, plant extract, biology and cosmetics, a plurality of subjects, and product development work awaits further to deepen.There is the market demand just to have development, develops and much more more be the basis, possess the handwashing disinfection liquid of various characteristics,, become the responsibility of vast sterilization field researcher to satisfy the growing consumption demand of broad masses of the people with new material, new technology.
The wash one's hands stability of product of sterilization class is to be difficult to the problem that solves, after in a single day the common handwashing disinfection liquid that has dirt-removing power on the market add disinfection composition, can occur going bad, wild effects such as deposition, layering.As with 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether is the preparation of the product of washing one's hands of main disinfection composition, just exists above problem, very difficult screening obtains stable technology preparation.
What therefore, contain in the market comprises 2,4; 4 '-three chloro-2 '-the dihydroxy diphenyl ether composition is generally the leave alcohol gel at interior hand sanitizing fluid; The current research data shows: 2,4,4 '-three chloro-2 '-the dihydroxy diphenyl ether alcohol gel is the leave hand sanitizing fluid; Dirt-removing power is poor, has only 45% medical worker to be satisfied with to using gel.
In addition, a research recently shows that also the gel that contains the alcohol in high concentration composition can let hands become dirtier.Because the easy defat of ethanol, vaporized alcohol can make skin become dry, cause trickle crackle and crack, and these crackles and crack can become the place of sheltering evil people and countenance evil practices.
Summary of the invention
The technical problem that the present invention will solve provides a kind of nursing type handwashing disinfection liquid.The disinfection composition can be well warm with the decontamination composition, and product is stable, can have decontamination concurrently, and the disinfectant function also can play the nursing multiple action to hand, is specially adapted to medical personnel and uses.
The technical scheme that the present invention addresses the above problem is:
A kind of nursing type handwashing disinfection liquid, described disinfectant solution is an aqueous solution, contains following weight ratio ingredient:
Disinfectant 0.1～5.0%
Surfactant 1.0～30.0%
Thickening agent 0.5～40.0%
Nursing agent 0.1～25.0%
PH regulator agent 0.05～2.0%, regulator solution pH5～7
Lipophilic solvent 0.0～30.0%.
The present invention also can add: essence 0.05～2.0%
Pigment 0.0001～0.002%.
The disinfectant of indication of the present invention can be Polyhaxemethylenguanidine Hydrochloride, o-phenyl phenol, parachlorometaxylenol, o-phenyl phenol sodium salt, wherein a kind of or mixture more than two kinds.
The disinfectant of indication of the present invention can be hibitane, povidone iodine, chlorhexidinium iodine, wherein a kind of or mixture more than two kinds.
The disinfectant of indication of the present invention better is a parachlorometaxylenol; 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ethers (triclosan) preferably.
Disinfectant consumption among the present invention better is 0.2～3.0%, preferably 0.5～2.0%.
The surfactant of indication of the present invention can be NPE, dodecylbenzene sodium sulfonate, sodium lauryl sulphate, trihydroxy ethylamine oleate soap, Oleum Cocois alkylolamides, trihydroxy ethylamine oleate soap etc., wherein a kind of or mixture more than two kinds; Can be polyoxyethylenated alcohol sodium sulfate (AES), a-sodium olefin sulfonate (AOS), wherein a kind of or mixture more than two kinds.
Preferably polyoxyethylenated alcohol sodium sulfate of the surfactant of indication of the present invention (AES), a-sodium olefin sulfonate (AOS), wherein a kind of or mixture more than two kinds.
Dosage of surfactant among the present invention better is 2.0～20%, preferably 3.0～10.0%.
The thickening agent of indication of the present invention can be carboxymethyl cellulose, polyvinylpyrrolidone, and wherein a kind of or mixture more than two kinds can be a Polyethylene Glycol.
The thickening agent of indication of the present invention is Polyethylene Glycol (comprising wherein a kind of or mixture more than two kinds of cetomacrogol 1000,4000,6000,8000,10000) preferably.
Thickening agent consumption among the present invention better is 0.5～35%, preferably 10～30.0%.
The nursing agent of indication of the present invention is the material that the adversary has nursing role, can be lanoline, vitamin E, olive oil, carbamide, glycerol, wherein a kind of or mixture more than two kinds.
The nursing agent of indication of the present invention is glycerol preferably.
Nursing agent consumption among the present invention better is 0.5～20.0%, preferably 5.0～15.0%.
The pH regulator agent of indication of the present invention can be ethylenediaminetetraacetic acid, sodium tetraborate, trisodium citrate, citric acid, wherein a kind of or mixture more than two kinds.
The pH regulator agent of indication of the present invention is citric acid preferably.
PH regulator agent consumption among the present invention better is 0.05～1.0%, preferably 0.1～0.5%.
The essence of indication of the present invention can be various natural essences such as jasmine flower essence, rose essence, Folium Artemisiae Argyi essence, wherein a kind of or mixture more than two kinds.
The essence of indication of the present invention is Folium Artemisiae Argyi essence preferably.
Essence consumption among the present invention better is 0.05～1.0%, preferably 0.1～0.5%.
The pigment of indication of the present invention can be various pigments such as pink, bright green, wherein a kind of or mixture more than two kinds.Can consider to add colour fixative in addition, fade to prevent pigment.
The pigment of indication of the present invention is sapphirine, amaranth preferably, wherein a kind of or two kinds of mixture.
Pigment consumption among the present invention better is 0.0001～0.001%, preferably 0.0001～0.0005%.
The lipophilic solvent of indication of the present invention can be propylene glycol, butanols, ethanol, isopropyl alcohol etc., wherein a kind of or mixture more than two kinds.
The lipophilic solvent of indication of the present invention is ethanol, isopropyl alcohol preferably, wherein a kind of or two kinds of mixture.
Lipophilic solvent consumption among the present invention better is 5.0～25.0%, preferably 10.0～20.0%.
Enforcement of the present invention can be carried out mutual any proportioning by above each component that provides and each constituent content scope.
The inventor on the basis of the above scheme that provides, according to compound mode provided by the present invention, several groups of preferred versions below the providing further.
The present invention more preferably one of scheme is: described disinfectant solution is an aqueous solution, comprises following weight ratio ingredient:
Disinfectant 0.2～3.0%
Surfactant 2.0～20.0%
Thickening agent 0.5～35.0%
Nursing agent 0.1～25.0%
PH regulator agent 0.05～2.0%, regulator solution pH5～7
Lipophilic solvent 0～30.0%.
Thickening agent can further be selected from 10～30.0% the scope in this preferred version.
Nursing agent can further be selected from 0.5～20.0% the scope in this preferred version.
Lipophilic solvent can further be selected from 5～25% the scope in this preferred version.
One of most preferred scheme of the present invention is: described disinfectant solution is an aqueous solution, comprises following weight ratio ingredient:
Disinfectant 0.5～2.0%
Surfactant 3.0～10.0%
Thickening agent 10～30.0%
Nursing agent 5～15.0%
PH regulator agent 0.05～2.0%, regulator solution pH5～7
Lipophilic solvent 10～20.0%.
In above-mentioned several groups of preferred versions, each composition preferably be: disinfectant can be parachlorometaxylenol or 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether (triclosan); Surfactant can be polyoxyethylenated alcohol sodium sulfate (AES), a-sodium olefin sulfonate (AOS); Thickening agent can be a Polyethylene Glycol; Nursing agent can be a glycerol; The pH regulator agent can be a citric acid; Lipophilic solvent can be a kind of or two kinds of mixture in ethanol, the isopropyl alcohol.
The method for preparing of handwashing disinfection liquid of the present invention is:
(1) dissolving: get surfactant, add suitable quantity of water, heating is constantly stirred and is made dissolving, gets solution A, adds thickening agent, and heating is constantly stirred and made dissolving, gets solution B, and is subsequent use; The cancellation toxic agent adds lipophilic solvent, stirs and makes dissolving, adds essence, stirs, and gets solution C, and is subsequent use;
(2) allotment: in the solution B, add nursing agent, pigment successively, stir; Add solution C, stir; Add the pH regulator agent, stirring promptly gets.
The method for using of product of the present invention:
Get this handwashing disinfection liquid 2ml in the palm of the hand, fully rub after 1 minute clear water and wash down and get final product.
Handwashing disinfection liquid of the present invention mainly has disinfective action except having washing, nursing role, can kill pathogenic entero becteria, pyococcus and pathogenic yeast.What play cleaning function in the prescription is surfactant, and what play nursing role is nursing agent, and the part thickening agent has nursing role in addition, and what play disinfective action is disinfectant, and lipophilic solvent, part essence have auxiliary disinfective action in addition.
In preferred version of the present invention, disinfectant is added surfactant for we and other complementary compositions form stable system, form contain 2,4,4 '-three chloro-2 '-the compound recipe handwashing disinfection liquid of compositions such as dihydroxy diphenyl ether, surfactant, the skin protection factor; Preferred through to formula for a product obviously improved 2,4; 4 '-three chloro-2 '-saturation solubility and the stability of dihydroxy diphenyl ether in aqueous solution, thus improve 2,4; 4 '-three chloro-2 '-bactericidal activity of dihydroxy diphenyl ether; Owing in the prescription surfactant is arranged, can effectively remove the dirt of skin surface, thereby Disinfection Effect is more remarkable.
Because related nursing type handwashing disinfection liquid of the present invention is a kind of homogeneous prescription; The alcohol type component content is very low; And added the skin protection factor, and can reduce owing to the chapped skin and the irritant dermatitis of frequently washing one's hands and causing, can reach the multiple effect of washing, sterilization and skin protection.Therefore, the present invention is the sterilized effect of a kind of both tools, and gentle novel handwashing disinfection agent.
Protective effect to the photoaging model mice skin of ultraviolet induction
1.1 test product and reagent
Test product: instance 1, instance 2, instance 3, instance 4
Reagent: SOD, GSH-Px, MDA, CAT and Hyp test kit (the biological engineering company limited is built up in Nanjing).
1.2 animal
Healthy Kunming mouse, female, body weight 18～22g, mice is divided into 6 groups at random: normal control group, model control group, 1 group of instance, 2 groups of instances, 3 groups of instances, 4 groups of instances.
1.3 method and result
With the depilation of 4% sodium sulfide, depilation is 1 time after later per two all end of radiation, until end of radiation before irradiation and administration first for mice.The normal control group is only lost hair or feathers, and does not shine, and does not give test product.The mice that will lose hair or feathers places (UVA+UVB, solar simulated) under the uviol lamp, shines weekly 3 times.The 1st all exposure doses are each 2Mj/cm
2, and with each 2mJ/cm weekly
2Dosage escalation, until each 8mJ/cm of the 4th week
2Later on by this dosage and 8 weeks of prolonged exposure to the.Record through UVA, UVB ultraviolet measurement appearance, total radiation dose UVA is 11.7J/cm
2, UVB is 156mJ/cm
2Each irradiation back is smeared test product respectively to the test product group, after wipe clean.Each organizes whole experimental session, observes back part of animal skin every day and has or not erythema, blister, erosion etc., if above-mentioned any situation stops to shine 2～3d immediately, proceeds irradiation again until transference cure.
Get the about 0.5g of back depilation skin histology, subcutaneous fat and other connective tissues are removed in the rinsing of pre-cooling normal saline, and filter paper is wiped away dried, weighs.Pour in the beaker of piece in a organized way, shred skin, add 9 times of weight pre-cooling normal saline, ice bath homogenate.Through 4 ℃, the centrifugal 15min of 8000r/min gets supernatant, measures SOD, GSH-Px, CAT activity and MDA, Hyp content respectively by the test kit explanation.
The result sees the following form
Each index change list (n=10) of skin histology
The result shows that each instance all can significantly increase in the mouse skin tissue total SOD, GSH-Px, CAT and Hyp content and significantly reduce MDA content (P＜0.01).Explain that this sterilized articles therefrom has the skin nursing effect.
In order to understand the present invention better, the technique effect that will have through evidence the present invention below.Laboratory sample adopts embodiment 2.
1. the staphylococcus aureus carrier is soaked and quantitatively kill test
The preparation of outstanding bacterium liquid
Staphylococcus aureus ATCC6538 (being provided by Military Medical Science Institute) bacteria suspension: the fresh slant culture that the 24h that learns from else's experience cultivates washes lawn with diluent earlier.The reuse nutrient broth is diluted to desired concn, gets 0.02ml on sterilizing cloth sheet carrier with dripping the method for dying, and makes the recovery bacterium reach 5 * 10
5～5 * 10
6The cfu/ sheet, it is subsequent use to put 37 ℃ of incubator inner dryings.
The nertralizer qualification test
Test is carried out in 20 ℃ ± 1 ℃ water-bath.Earlier handwashing disinfection liquid stock solution and other are treated that test solution puts preparatory temperature 5min in the water-bath, carry out the neutralization test determination by 6 groups again.The test microorganism is a staphylococcus aureus.It is the TSB of 1.0% glycine, 2.0% sodium thiosulfate, 3.0% tween 80,0.1% lecithin that plan is chosen mediating recipe, and the bactericidal action time is 0.5min, and the neutralization time is 10min.Sampling is counted with the tryptose soya agar culture medium ware that inclines.Test repetition 3 times.Temperature is 21 ℃～23 ℃, and humidity is 55%～60%.
Carrier soaks quantitative disinfecting test
Test is carried out in 20 ℃ ± 1 ℃ water-bath.Earlier handwashing disinfection liquid stock solution is added in the sterilization plate by every 5.0ml.Put preparatory temperature 5min～10min in the water-bath, add the microbiological contamination carrier, act on to the scheduled time, carrier is taken out to add contain in the 5.0ml nertralizer test tube, in 10min after, sampling is counted with the tryptose soya agar culture medium ware that inclines.The positive, negative control are established in test simultaneously.Test repetition 3 times.
Table 1 nertralizer qualification test result (the test microorganism is a staphylococcus aureus)
Experimental result shows that nertralizer is that the TSB of 1.0% glycine, 2.0% sodium thiosulfate, 3.0% tween 80,0.1% lecithin can neutralize residual this handwashing disinfection liquid stock solution to the killing action of staphylococcus aureus, and nertralizer and neutralized reaction product all have no adverse effects to growth and the culture medium of being tried bacterium.
Table 2 handwashing disinfection liquid is to the killing effect of staphylococcus aureus
Experimental result shows that handwashing disinfection liquid stock solution effect 0.5min kills each time of logarithm value all greater than 3.00 to staphylococcus aureus.
2. the Candida albicans carrier is soaked and quantitatively kill test
The preparation of outstanding bacterium liquid
Candida albicans ATCC10231 (being provided by Military Medical Science Institute) bacteria suspension: the fresh slant culture that the 24h that learns from else's experience cultivates washes lawn with diluent earlier.The reuse nutrient broth is diluted to desired concn, gets 0.02ml on sterilizing cloth sheet carrier with dripping the method for dying, and makes the recovery bacterium reach 5 * 10
5～5 * 10
6The cfu/ sheet, it is subsequent use to put 37 ℃ of incubator inner dryings.
The nertralizer qualification test
Test is carried out in 20 ℃ ± 1 ℃ water-bath.Earlier handwashing disinfection liquid stock solution and other are treated that test solution puts preparatory temperature 5min in the water-bath, carry out the neutralization test determination by 6 groups again.The test microorganism is white beads.It is the TSB of 1.0% glycine, 2.0% sodium thiosulfate, 3.0% tween 80,0.1% lecithin that plan is chosen mediating recipe, and the bactericidal action time is 0.5min, and the neutralization time is 10min.Sampling is counted with the husky Bao Shi agar culture medium ware that inclines.Test repetition 3 times.Temperature is 21 ℃～23 ℃, and humidity is 55%～60%.
Carrier soaks quantitative disinfecting test
Test is carried out in 20 ℃ ± 1 ℃ water-bath.Earlier handwashing disinfection liquid stock solution is added in the sterilization plate by every 5.0ml.Put preparatory temperature 5min～10min in the water-bath, add the microbiological contamination carrier, act on to the scheduled time, carrier is taken out to add contain in the 5.0ml nertralizer test tube, in 10min after, sampling is counted with the husky Bao Shi agar culture medium ware that inclines.The positive, negative control are established in test simultaneously.Test repetition 3 times.
Table 3 nertralizer qualification test result (the test microorganism is a Candida albicans)
Experimental result shows that nertralizer is that the TSB of 1.0% glycine, 2.0% sodium thiosulfate, 3.0% tween 80,0.1% lecithin can neutralize residual this handwashing disinfection liquid stock solution to the oidiomycetic killing action of white, and nertralizer and neutralized reaction product all have no adverse effects to growth and the culture medium of being tried bacterium.
Table 4 handwashing disinfection liquid is to the oidiomycetic killing effect of white
Experimental result shows that handwashing disinfection liquid stock solution effect 1.0min kills each time of logarithm value all greater than 3.00 to white is oidiomycetic.
3. escherichia coli vector is soaked and quantitatively kill test
The preparation of outstanding bacterium liquid
Escherichia coli 8099 (being provided by Military Medical Science Institute) bacteria suspension: the fresh slant culture that the 24h that learns from else's experience cultivates washes lawn with diluent earlier.The reuse nutrient broth is diluted to desired concn, gets 0.02ml on sterilizing cloth sheet carrier with dripping the method for dying, and makes the recovery bacterium reach 5 * 10
5～5 * 10
6The cfu/ sheet, it is subsequent use to put 37 ℃ of incubator inner dryings.
The nertralizer qualification test
Test is carried out in 20 ℃ ± 1 ℃ water-bath.Earlier handwashing disinfection liquid stock solution and other are treated that test solution puts preparatory temperature 5min in the water-bath, carry out the neutralization test determination by 6 groups again.The test microorganism is a staphylococcus aureus.It is the TSB of 1.0% glycine, 2.0% sodium thiosulfate, 3.0% tween 80,0.1% lecithin that plan is chosen mediating recipe, and the bactericidal action time is 0.5min, and the neutralization time is 10min.Sampling is counted with the tryptose soya agar culture medium ware that inclines.Test repetition 3 times.Temperature is 21 ℃～23 ℃, and humidity is 55%～60%.
Carrier soaks quantitative disinfecting test
Test is carried out in 20 ℃ ± 1 ℃ water-bath.Earlier handwashing disinfection liquid stock solution is added in the sterilization plate by every 5.0ml.Put preparatory temperature 5min～10min in the water-bath, add the microbiological contamination carrier, act on to the scheduled time, carrier is taken out to add contain in the 5.0ml nertralizer test tube, in 10min after, sampling is counted with the tryptose soya agar culture medium ware that inclines.The positive, negative control are established in test simultaneously.Test repetition 3 times.
Table 5 handwashing disinfection liquid is to colibacillary killing effect
Experimental result shows that handwashing disinfection liquid stock solution effect 0.5min kills each time of logarithm value all greater than 3.00 to colibacillary.
4. health hands sterilization field trial
(1) equipment
Disinfection nursing handwashing disinfection liquid;
Sample solution: the TSB that contains 1.0% glycine, 2.0% sodium thiosulfate, 3.0% tween 80,0.1% lecithin;
Diluent: 0.1% tween 80 PBS;
Sampling is with the cotton swab of sterilization;
Sterilization objects: hands;
Local 100 grades of air cleaning laboratorys.
(2) method
Test basis: " disinfection technology standard " 2002 editions 2.1.2.6;
Use decontaminant concentration and processing method: the right hand is carried out disinfection behind the 1.0min with disinfection nursing handwashing disinfection liquid; With the sample solution that contains nertralizer at the five fingers curved surface finger tip to referring to that root comes and goes twice of wiping; After the sampling; The cotton swab sampling end is cut in the sample solution test tube that contains nertralizer, and fully behind the mixing, sampling is counted with the tryptose soya agar culture medium ware that inclines.In kind left hand is sampled with sample solution, be positive control.Negative control is established in test simultaneously.
Action time: 1.0min.
Temperature and relative humidity: T:21～23 during test, RH:55～60%.
(3) result
Through 30 times to health hands sterilization field trial, this disinfection nursing handwashing disinfection liquid stock solution effect 1.0min, to health on hand the minimum logarithm value of killing of natural bacteria be 1.05.Be that handwashing disinfection liquid stock solution effect 1.0min kills logarithm value all greater than 1.00 to health natural bacteria on hand.
The specific embodiment
Instance 1
The composition of handwashing disinfection liquid of the present invention:
Parachlorometaxylenol 2.0%
Polyoxyethylenated alcohol sodium sulfate (AES) 0.5%
A-sodium olefin sulfonate (AOS) 3.0%
Polyethylene glycol 6000 30%
Glycerol 15%
Citric acid 0.1%
Essence 0.1%
Pigment 0.0005%
95% ethanol 20%
Water adds to 100%
The virus killing effect: stock solution effect 0.5min, kill logarithm value all＞3.00 to staphylococcus aureus and escherichia coli; Stock solution effect 1min kills logarithm value all＞3.00 to Candida albicans; Stock solution effect 1min, to health on hand natural bacteria kill logarithm value all＞1.00.
System stability: system is the liquid of single stable, and 37 ℃ ± 2 ℃ of temperature, 3 months test sample each items of condition held quality index of relative humidity 75% ± 5% does not have significant change.
Instance 2
The composition of handwashing disinfection liquid of the present invention:
2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether 1.0%
Polyoxyethylenated alcohol sodium sulfate (AES) 0.5%
A-sodium olefin sulfonate (AOS) 3.0%
Polyethylene glycol 6000 30%
Glycerol 15%
Citric acid 0.1%
Essence 0.1%
Pigment 0.0005%
95% ethanol 20%
Water adds to 100%
The virus killing effect: stock solution effect 0.5min, kill logarithm value all＞3.00 to staphylococcus aureus and escherichia coli; Stock solution effect 1min kills logarithm value all＞3.00 to Candida albicans; Stock solution effect 1min, to health on hand natural bacteria kill logarithm value all＞1.00.
System stability: system is the liquid of single stable, and 37 ℃ ± 2 ℃ of temperature, 3 months test sample each items of condition held quality index of relative humidity 75% ± 5% does not have significant change.
Instance 3
The composition of handwashing disinfection liquid of the present invention:
Chlorhexidinium iodine 1.0%
Polyoxyethylenated alcohol sodium sulfate (AES) 0.5%
Oleum Cocois alkylolamides 10.0%
Cetomacrogol 1000 20%
Glycerol 10%
Citric acid 0.1%
Essence 0.1%
Pigment 0.0005%
95% ethanol 20%
Water adds to 100%
The virus killing effect: stock solution effect 0.5min, kill logarithm value all＞3.00 to staphylococcus aureus and escherichia coli; Stock solution effect 1min kills logarithm value all＞3.00 to Candida albicans; Stock solution effect 1min, to health on hand natural bacteria kill logarithm value all＞1.00.
System stability: system is the liquid of single stable, and 37 ℃ ± 2 ℃ of temperature, 3 months test sample each items of condition held quality index of relative humidity 75% ± 5% does not have significant change.
Instance 4
The composition of handwashing disinfection liquid of the present invention:
2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether 1.0%
Polyoxyethylenated alcohol sodium sulfate (AES) 0.5%
A-sodium olefin sulfonate (AOS) 3.0%
Polyethylene Glycol 8,000 20%
Glycerol 15%
Citric acid 0.1%
Essence 0.1%
Pigment 0.0005%
95% ethanol 20%
Water adds to 100%
The virus killing effect: stock solution effect 0.5min, kill logarithm value all＞3.00 to staphylococcus aureus and escherichia coli; Stock solution effect 1min kills logarithm value all＞3.00 to Candida albicans; Stock solution effect 1min, to health on hand natural bacteria kill logarithm value all＞1.00.
System stability: system is the liquid of single stable, and 37 ℃ ± 2 ℃ of temperature, 3 months test sample each items of condition held quality index of relative humidity 75% ± 5% does not have significant change.
Instance 5
The composition of handwashing disinfection liquid of the present invention:
2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether 1.0%
Polyoxyethylenated alcohol sodium sulfate (AES) 0.5%
A-sodium olefin sulfonate (AOS) 3.0%
Cetomacrogol 1000 0 20%
Glycerol 15%
Citric acid 0.1%
Essence 0.1%
Pigment 0.0005%
95% ethanol 20%
Water adds to 100%
The virus killing effect: stock solution effect 0.5min, kill logarithm value all＞3.00 to staphylococcus aureus and escherichia coli; Stock solution effect 1min kills logarithm value all＞3.00 to Candida albicans; Stock solution effect 1min, to health on hand natural bacteria kill logarithm value all＞1.00.
System stability: system is the liquid of single stable, and 37 ℃ ± 2 ℃ of temperature, 3 months test sample each items of condition held quality index of relative humidity 75% ± 5% does not have significant change.
Instance 6
The composition of handwashing disinfection liquid of the present invention:
O-phenyl phenol 2.0%
Oleum Cocois alkylolamides 10.5%
A-sodium olefin sulfonate (AOS) 3.0%
Polyvinylpyrrolidone 1.0%
Glycerol 5%
Citric acid 0.1%
Essence 0.1%
Pigment 0.0005%
95% ethanol 5%
Water adds to 100%
The virus killing effect: stock solution effect 0.5min, kill logarithm value all＞3.00 to staphylococcus aureus and escherichia coli; Stock solution effect 1min kills logarithm value all＞3.00 to Candida albicans; Stock solution effect 1min, to health on hand natural bacteria kill logarithm value all＞1.00.
System stability: system is the liquid of single stable, and 37 ℃ ± 2 ℃ of temperature, 3 months test sample each items of condition held quality index of relative humidity 75% ± 5% does not have significant change.
Instance 7
The composition of handwashing disinfection liquid of the present invention:
Parachlorometaxylenol 2.0%
NPE 3.5%
Dodecylbenzene sodium sulfonate 5.0%
Polyethylene Glycol 8,000 20%
Glycerol 10%
Citric acid 0.1%
Essence 0.1%
Pigment 0.0005%
95% ethanol 20%
Water adds to 100%
The virus killing effect: stock solution effect 0.5min, kill logarithm value all＞3.00 to staphylococcus aureus and escherichia coli; Stock solution effect 1min kills logarithm value all＞3.00 to Candida albicans; Stock solution effect 1min, to health on hand natural bacteria kill logarithm value all＞1.00.
System stability: system is the liquid of single stable, and 37 ℃ ± 2 ℃ of temperature, 3 months test sample each items of condition held quality index of relative humidity 75% ± 5% does not have significant change.
Instance 8
The composition of handwashing disinfection liquid of the present invention:
Parachlorometaxylenol 3.0%
Polyoxyethylenated alcohol sodium sulfate (AES) 0.5%
A-sodium olefin sulfonate (AOS) 3.0%
Cetomacrogol 1000 0 15%
Glycerol 15%
Citric acid 0.1%
Essence 0.1%
Pigment 0.0005%
95% ethanol 20%
Water adds to 100%
The virus killing effect: stock solution effect 0.5min, kill logarithm value all＞3.00 to staphylococcus aureus and escherichia coli; Stock solution effect 1min kills logarithm value all＞3.00 to Candida albicans; Stock solution effect 1min, to health on hand natural bacteria kill logarithm value all＞1.00.
System stability: system is the liquid of single stable, and 37 ℃ ± 2 ℃ of temperature, 3 months test sample each items of condition held quality index of relative humidity 75% ± 5% does not have significant change.
Though, in the preceding text, with general explanation and concrete embodiment the present invention has been done detailed explanation, on basis of the present invention, can do some modifications or improvement, this will be apparent to those skilled in the art.Therefore, modification or the improvement on the basis of not departing from spirit of the present invention, made all belong to the scope that requirement of the present invention is protected.
Claims (9)
1. nursing type handwashing disinfection liquid, described disinfectant solution is an aqueous solution, contains following weight ratio ingredient:
Said lipophilic solvent is a wherein a kind of or mixture more than two kinds of propylene glycol, butanols, ethanol, isopropyl alcohol;
Said disinfectant is an a kind of or mixture more than two kinds in parachlorometaxylenol, o-phenyl phenol, the o-phenyl phenol sodium salt; Or 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether;
Surfactant is a kind of in NPE, dodecylbenzene sodium sulfonate, sodium lauryl sulphate, trihydroxy ethylamine oleate soap, the Oleum Cocois alkylolamides or mixture more than two kinds; Or a kind of in the polyoxyethylenated alcohol sodium sulfate, α-sodium olefin sulfonate or their mixture;
Described thickening agent is a Polyethylene Glycol; Or polyvinylpyrrolidone;
Described nursing agent is a glycerol;
The pH regulator agent is a citric acid.
2. a kind of nursing type handwashing disinfection liquid according to claim 1, the weight content of disinfectant in handwashing disinfection liquid is 0.2～3.0%.
3. a kind of nursing type handwashing disinfection liquid according to claim 1, the weight content of disinfectant in handwashing disinfection liquid is 0.5～2.0%.
4. a kind of nursing type handwashing disinfection liquid according to claim 1, the weight content of surfactant in handwashing disinfection liquid is 2.0～20%.
5. a kind of nursing type handwashing disinfection liquid according to claim 1, the weight content 0.5～35% of thickening agent in handwashing disinfection liquid,
6. a kind of nursing type handwashing disinfection liquid according to claim 5, the weight content of thickening agent in handwashing disinfection liquid is 10～30.0%.
7. a kind of nursing type handwashing disinfection liquid according to claim 1, the weight content of nursing agent in handwashing disinfection liquid is 0.5～20.0%.
8. a kind of nursing type handwashing disinfection liquid according to claim 1 comprises following weight ratio ingredient:
Each composition is: disinfectant is parachlorometaxylenol or 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether; Surfactant is polyoxyethylenated alcohol sodium sulfate, α-sodium olefin sulfonate; Thickening agent is a Polyethylene Glycol; Nursing agent is a glycerol; The pH regulator agent is a citric acid; Lipophilic solvent is a kind of or two kinds of mixture in ethanol, the isopropyl alcohol.
9. a kind of nursing type handwashing disinfection liquid according to claim 8 comprises following weight ratio ingredient:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110025453 CN102085159B (en) | 2011-01-24 | 2011-01-24 | Nursing type disinfecting liquid soap |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110025453 CN102085159B (en) | 2011-01-24 | 2011-01-24 | Nursing type disinfecting liquid soap |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102085159A CN102085159A (en) | 2011-06-08 |
| CN102085159B true CN102085159B (en) | 2012-12-05 |
Family
ID=44097324
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110025453 Active CN102085159B (en) | 2011-01-24 | 2011-01-24 | Nursing type disinfecting liquid soap |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102085159B (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103655227A (en) * | 2012-09-24 | 2014-03-26 | 天津博克尼科技发展有限公司 | Disinfection liquid soap |
| CN103768007A (en) * | 2012-10-26 | 2014-05-07 | 杭州元祺生物科技有限公司 | Medical disinfecting gel |
| CN102988335A (en) * | 2012-11-29 | 2013-03-27 | 王便草 | Antifungal composition |
| CN103893043A (en) * | 2012-12-28 | 2014-07-02 | 青岛锦涟鑫商贸有限公司 | Method for manufacturing disinfectant hand cleaner |
| CN104644493B (en) * | 2014-11-18 | 2017-09-12 | 安阳工学院 | A kind of hand cleanser containing natural bacteriostatic composition |
| CN104490936A (en) * | 2014-11-28 | 2015-04-08 | 成都顺发消洗科技有限公司 | Skin disinfectant |
| CN104473972A (en) * | 2014-11-28 | 2015-04-01 | 成都顺发消洗科技有限公司 | Method for preparing skin disinfectant |
| CN104606119A (en) * | 2015-02-13 | 2015-05-13 | 南通蛇类治疗研究所 | Sterilizing and disinfecting waterless hand cleaner |
| CN104840410B (en) * | 2015-05-28 | 2018-03-09 | 福建农林大学 | A kind of disposable hand disinfection liquid and its preparation and application |
| CN104940191B (en) * | 2015-06-01 | 2018-10-12 | 武汉胜达康生物科技有限公司 | A kind of fat-soluble nutgall catechin gallic acid palmitate disinfectant and preparation method |
| CN105997961A (en) * | 2016-07-21 | 2016-10-12 | 南通东华服装有限公司 | Multifunctional antibacterial hand-cleaning sanitizer |
| CN106236604A (en) * | 2016-10-12 | 2016-12-21 | 易洁(北京)科技有限公司 | A kind of handwashing liquid processing technology |
| CN106614781A (en) * | 2016-12-23 | 2017-05-10 | 叶宗瑞 | Household disinfectant and preparation method thereof |
| CN107669667A (en) * | 2017-09-27 | 2018-02-09 | 潍坊天辰生物技术有限公司 | Nursing type disinfecting liquid soap preparation |
| CN107496448A (en) * | 2017-09-30 | 2017-12-22 | 蚌埠科卫消毒药剂有限公司 | A kind of Povidone Iodine Disinfection Solution and preparation method thereof |
| CN107595881A (en) * | 2017-09-30 | 2018-01-19 | 蚌埠科卫消毒药剂有限公司 | A kind of skin mucosa disinfectant and preparation method thereof |
| CN109247343A (en) * | 2018-11-20 | 2019-01-22 | 娇时日化（杭州）股份有限公司 | A kind of thimerosal and preparation method thereof containing tea tree ethereal oil |
| CN110201530A (en) * | 2019-06-19 | 2019-09-06 | 山西云汇运通环保科技有限公司 | A kind of purification air active ingredient and preparation method thereof |
| CN110280126A (en) * | 2019-06-19 | 2019-09-27 | 山西云汇运通环保科技有限公司 | It is a kind of to purify air combined biologically active agents and preparation method thereof |
| CN111202088A (en) * | 2020-03-06 | 2020-05-29 | 吉林云飞医药有限公司 | Chlorhexidine acetate disinfectant and preparation method and application thereof |
| CN111329824A (en) * | 2020-04-02 | 2020-06-26 | 东元科技有限公司 | Hand sanitizer with strong sterilization capability |
| CN112336671A (en) * | 2020-11-20 | 2021-02-09 | 山东消博士消毒科技股份有限公司 | Skin-care disinfectant and preparation method thereof |
| CN112402293A (en) * | 2020-11-30 | 2021-02-26 | 孙彬彬 | Sustained-release water-based hand sanitizer containing polyvinylpyrrolidone |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1170036A (en) * | 1996-06-28 | 1998-01-14 | 徐彩荣 | Waterless detergent for dry cleaning |
| CN101684435A (en) * | 2008-09-28 | 2010-03-31 | 福建恒安集团有限公司 | Sterilization hand washing solution |
-
2011
- 2011-01-24 CN CN 201110025453 patent/CN102085159B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1170036A (en) * | 1996-06-28 | 1998-01-14 | 徐彩荣 | Waterless detergent for dry cleaning |
| CN101684435A (en) * | 2008-09-28 | 2010-03-31 | 福建恒安集团有限公司 | Sterilization hand washing solution |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102085159A (en) | 2011-06-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102085159B (en) | Nursing type disinfecting liquid soap | |
| AU2010242866B2 (en) | Cleanser compositions and methods for using the same | |
| CN100374099C (en) | Antimicrobial composition | |
| CN106793784A (en) | Vegetalitas antimicrobial compositions | |
| US6352702B1 (en) | Antimicrobial composition | |
| US20100120915A1 (en) | Antimicrobials and related methods | |
| JP6023756B2 (en) | Composition for skin care, fungus body, dried fungus body and collection tool | |
| CN100394909C (en) | Antiseptic hand cleaning liquid with out water cleaning and its preparation method | |
| US20060074029A1 (en) | Topical antimicrobial composition having improved moisturization properties | |
| CN103813799A (en) | Disinfecting formulations and uses thereof | |
| CN104274376A (en) | Environment-friendly decontaminating hand sanitizer and preparation method thereof | |
| CN101548983A (en) | Skin disinfectant and method of producing the same | |
| CN104490720B (en) | Antibacterial peptide hand sanitizer and preparation method thereof | |
| CN109512741A (en) | A kind of essential oil is washed one's hands condensation and preparation method thereof | |
| CN103251516A (en) | Preparation method of skin-care disinfecting and sterilizing hand sanitizer | |
| CN106726956A (en) | A kind of antibacterial skin moistening liquid soap and preparation method thereof | |
| RU2359704C2 (en) | Antiseptic and disinfectant | |
| CN104207970A (en) | Medical skin-care disinfection hand-cleaning liquid and preparation method thereof | |
| CN104207971B (en) | Medical skin-disinfection and -nursing hand-cleaning liquid and preparation method thereof | |
| CN103271841A (en) | Traditional Chinese medicine hand washing lotion | |
| Elfrida et al. | Effect of piper betle linn extract on the growth of Staphylococcus aureus atcc 25923 | |
| CN105997964A (en) | Efficacy type sterilization and disinfection liquid containing natural citral-bletilla striata polysaccharide polymer and preparation method thereof | |
| WO2021259211A1 (en) | Antiseptic compositions | |
| CN108653017A (en) | Children's type disinfecting liquid and preparation method thereof | |
| CN108653091A (en) | Disposable hand sanitizing fluid and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |