CN101947342A - Drug administrator, drug administration device and drug administration method for nasal cavity mucous membrane - Google Patents
Drug administrator, drug administration device and drug administration method for nasal cavity mucous membrane Download PDFInfo
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- CN101947342A CN101947342A CN 201010270626 CN201010270626A CN101947342A CN 101947342 A CN101947342 A CN 101947342A CN 201010270626 CN201010270626 CN 201010270626 CN 201010270626 A CN201010270626 A CN 201010270626A CN 101947342 A CN101947342 A CN 101947342A
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Abstract
The invention relates to a drug administrator and a drug administration method for a nasal cavity mucous membrane. The drug administrator for the nasal cavity mucous membrane comprises a port end, a spray end and a flexible connecting pipe for communicating the port end with the spray end, wherein a micropore for atomizing and spraying drug liquid under the pressure is arranged on the end head of the spray end; and a nasal tampon is sheathed on the spray end; and the end head is exposed out of the front end of the nasal tampon. The invention also provides a drug administration device for the nasal cavity mucous membrane with the drug administrator. The invention has the advantages of convenient drug administration, quick absorption and fast drug effect action.
Description
Technical field
The present invention relates to medical medicine and grant, particularly relate to a kind of nasal administration device, doser and medication.
Background technology
At present, in the medical industry, mostly traditional administering mode is oral administration and drug administration by injection (comprising intramuscular injection and intravenous injection).Though oral administration is convenient, but during oral administration, medicine is many to enter blood with diffusion way through gastrointestinal mucosa, along with arriving corresponding site, blood flow plays a role, medicine arrives diseased region not only needs a process, and be subjected to gastrointestinal tract plurality of enzymes and acid-base value influence easily, and little intestinal absorption is also incomplete, makes drug effect occur slow and reduction.So oral administration is difficult to reach effective therapeutic purposes sometimes.Drug administration by injection, medicine are slowly to enter blood from Musclar layer, and it is just fast more that the abundant more fraction medicine of blood vessel absorbs, and therefore absorb fast than oral administration.But the side effect of drug administration by injection is big than oral administration, and is rapid etc. such as causing tissue injury, local pain, potential complication, untoward reaction to occur easily, also can cause the fear of child patient.
Summary of the invention
Main purpose of the present invention is exactly the deficiency at oral administration and drug administration by injection, and simple and easy to do, rapidly effective nasal administration device, doser and medication are provided.
For achieving the above object, the present invention is by the following technical solutions:
A kind of nasal administration device, the flexible connection pipe that comprises described interface end of interface end, spraying end and connection and described spraying end, the termination of described spraying end has the micropore that atomizes and spray for medicinal liquid under pressure, be with nasal obstruction on the described spraying end, and expose from the front end of described nasal obstruction described termination.
Preferably, be provided with the female cone jack of the adaptive insertion in termination that supplies syringe in the described interface end.
Preferably, described flexible connection pipe has the two-chamber road, and wherein a tract is carried medicinal liquid, and another tract is placed with flexible strengthening core bar.
Preferably, described flexible strengthening core bar is a stainless steel silk.
Preferably, described nasal obstruction is coniform.
Preferably, described nasal obstruction is the silicone sponge material.
A kind of nasal administration device comprises medicinal liquid pushing equipment and aforesaid a kind of nasal administration device, and the transfusion end of described medicinal liquid pushing equipment connects the interface end of described nasal administration device.
Preferably, described medicinal liquid pushing equipment is a syringe.
A kind of nasal administration method may further comprise the steps:
A. the flexible connection pipe is sent into the person's nasal cavity that is subjected to the medicine, made the nasal obstruction on the spraying end strut the nostril, the termination of spraying end is in medicine-feeding part;
B. medicinal liquid is imported the flexible connection pipe from interface end, deliver to spraying end through described flexible connection pipe;
C. further medicinal liquid is bestowed pressure, make its micropore atomization ejection from described spraying end.
Preferably, described nasal obstruction is the silicone sponge material, and among the described step a, jam-pack nostril when described nasal obstruction struts the nostril is in case the medicinal liquid outflow.
Beneficial technical effects of the present invention is:
Nasal administration device of the present invention is the via intranasal application administration, and the process nasal mucosa absorbs and plays a role, and reaches the whole body therapeutic purpose.About 12 to 15 centimetres of people's nasal cavity length, about 15 milliliters of volume, the total surface area of nasal mucosa is about 150 square centimeters, and many big and porous blood capillaries and abundant lymph net are arranged under the nasal epithelial cells, the nose bronchia mucosal is relatively large in addition, and this just makes it become comparatively ideal mucosal drug delivery approach.Medicine directly enters the body circulation after nasal mucosa absorbs, can avoid medicine to degrade and liver first-pass effect in gastro-intestinal Fluid, the bioavailability height, and the small-molecule drug bioavailability is near quiet notes, and macromolecular drug is higher than oral.Compare with drug administration by injection, nasal administration is easy to use, medication voluntarily, and the slight or nothing to body injury, patient's compliance is good, and fibre-less toxicity and irritating pharmaceutical preparation are suitable for long term administration, and can reduce the propagation of infectious disease.Simultaneously, also be applicable to because a variety of causes and patient that can't oral administration.Use the present invention to nasal-cavity administration, drug absorption is rapid, and is rapid-action, and the nasal absorption speed of non-peptide medicament combines with its characteristics easy to use near quiet notes, is very suitable for first aid, saves oneself, the clinical practice of aspect such as calmness.
Description of drawings
Fig. 1 is the structural representation of embodiment of nasal administration device of the present invention with when nasal obstruction;
Fig. 2 is the cross sectional view of the connection tube of an embodiment of nasal administration device of the present invention;
Fig. 3 is the sketch map of the nasal obstruction of an embodiment of nasal administration device of the present invention;
Structural representation when Fig. 4 has a stuffy nose for embodiment band of nasal administration device of the present invention;
Fig. 5 is the structural representation of an embodiment of nasal administration device of the present invention.
The specific embodiment
In conjunction with the accompanying drawings the present invention is further described in detail by the following examples.
Please refer to Fig. 1 to Fig. 5, in one embodiment, the nasal administration device comprises interface end 1, connection tube 2, spraying end 3 and has a stuffy nose 5, and interface end 1, connection tube 2 and spraying end 3 are connected successively, and nasal obstruction 5 is enclosed within on the spraying end 3.Expose from 5 the front end of having a stuffy nose the termination 6 of spraying end 3, and a superfine little micropore A is arranged on the termination 6, can eject vaporific medicinal liquid D by this micropore.
As shown in Figure 1, the mid portion of nasal administration device is a connection tube 2, and it has flexible and flexible, and has certain length, can go deep into nasal cavity.As shown in Figure 2, preferably, described connection tube has the two-chamber road, and wherein a tract B carries medicinal liquid, and another tract C is placed with flexible strengthening core bar, and more preferably, the two-chamber road of flexible connection pipe be arranged in parallel.Flexible strengthening core bar can be a stainless steel silk.But flexible strengthening core bar has increased the rigidity and the shape stability of connection tube, self can also bend to difformity arbitrarily simultaneously, uses with convenient.
The two ends of connection tube 2 are respectively interface end 1 and spraying end 3.Interface end 1 can link to each other with the input medicinal liquid with the drug delivery device of a syringe or a similar effect.Preferably, be provided with a female cone jack 7 in interface end 1, the size and dimension of female cone jack can be designed to match with standard syringes, thus can with adaptive connection of transfusion termination of syringe.
Administrator after Fig. 3 and Fig. 4 have showed nasal obstruction respectively and put nasal obstruction.Nasal obstruction 5 is preferably coniform.The material of nasal obstruction preferably adopts silicone sponge.This nasal obstruction can strut and jam-pack patient nostril when spraying end inserts the patient nostril, makes the through nasal cavity depths of medicinal liquid of spraying end ejection and prevents that medicinal liquid from flowing out nasal cavity.Simultaneously, nasal obstruction soft or hard appropriateness and high resilience by make on the silicone rubber sea feel comfortably cool patient and take like a shot.
As shown in Figure 5, an embodiment of nasal administration device comprises syringe 4 and nasal administration device, and the transfusion termination of syringe 4 and the interface end 1 of nasal administration device are joined.
During use, syringe 4 interior suction medicinal liquids also insert in the female cone hole of interface end, touch the push rod of syringe 4 during administration, medicinal liquid enters spraying end 3 through interface end 1, connection tube 2, under the effect of push rod pressure, medicinal liquid is atomized ejection through the micropore of spraying end upper end part, enters patient's nasal cavity, reaches the purpose of administration.Can accurately control drug dose with the syringe administration.
Syringe is not essential, can adopt other device that can realize that liquid pushes to replace syringe yet.
On the other hand, the present invention also provides a kind of nasal administration method, and in one embodiment, this method may further comprise the steps:
A. the flexible connection pipe is sent into the person's nasal cavity that is subjected to the medicine, made the nasal obstruction on the spraying end strut the nostril, the termination of spraying end is in medicine-feeding part;
B. medicinal liquid is imported the flexible connection pipe from interface end, deliver to spraying end through described flexible connection pipe;
C. further medicinal liquid is bestowed pressure, make its micropore atomization ejection from described spraying end.
Preferably, nasal obstruction adopts the silicone sponge material, and among the described step a, jam-pack nostril when nasal obstruction struts the nostril is in case the medicinal liquid outflow.Preferably, have a stuffy nose to coniform.
The various embodiment of aforementioned nasal administration device can be used for the concrete enforcement of this medication equally, for example, can adopt syringe that medicinal liquid is pushed the incoming interface end, again for example, in the flexible connection pipe that this method adopted, can be provided with flexible strengthening core bar, this flexible strengthening core bar can be a stainless steel silk.
Above content be in conjunction with concrete preferred implementation to further describing that the present invention did, can not assert that concrete enforcement of the present invention is confined to these explanations.For the general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, can also make some simple deduction or replace, all should be considered as belonging to protection scope of the present invention.
Claims (10)
1. nasal administration device, it is characterized in that, the flexible connection pipe that comprises described interface end of interface end, spraying end and connection and described spraying end, the termination of described spraying end has the micropore that atomizes and spray for medicinal liquid under pressure, be with nasal obstruction on the described spraying end, expose from the front end of described nasal obstruction described termination.
2. nasal administration device as claimed in claim 1 is characterized in that, is provided with the female cone jack for the adaptive insertion in transfusion termination of syringe in the described interface end.
3. nasal administration device as claimed in claim 1 or 2 is characterized in that, described flexible connection pipe has the two-chamber road, and wherein a tract is carried medicinal liquid, and another tract is placed with flexible strengthening core bar.
4. nasal administration device as claimed in claim 3 is characterized in that, described flexible strengthening core bar is a stainless steel silk.
5. nasal administration device as claimed in claim 1 or 2 is characterized in that, described nasal obstruction is coniform.
6. nasal administration device as claimed in claim 1 or 2 is characterized in that, described nasal obstruction is the silicone sponge material.
7. a nasal administration device is characterized in that, comprises the medicinal liquid pushing equipment and according to aforementioned claim nasal administration device described in each, the transfusion end of described medicinal liquid pushing equipment connects the interface end of described nasal administration device.
8. nasal administration method as claimed in claim 7 is characterized in that, described medicinal liquid pushing equipment is a syringe.
9. a nasal administration method is characterized in that, may further comprise the steps:
A. the flexible connection pipe is sent into the person's nasal cavity that is subjected to the medicine, made the nasal obstruction on the spraying end strut the nostril, the termination of spraying end is in medicine-feeding part;
B. medicinal liquid is imported the flexible connection pipe from interface end, deliver to spraying end through described flexible connection pipe;
C. further medicinal liquid is bestowed pressure, make its micropore atomization ejection from described spraying end.
10. nasal administration method as claimed in claim 9 is characterized in that, described nasal obstruction is the silicone sponge material, and among the described step a, jam-pack nostril when described nasal obstruction struts the nostril is in case the medicinal liquid outflow.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010270626 CN101947342A (en) | 2010-09-02 | 2010-09-02 | Drug administrator, drug administration device and drug administration method for nasal cavity mucous membrane |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010270626 CN101947342A (en) | 2010-09-02 | 2010-09-02 | Drug administrator, drug administration device and drug administration method for nasal cavity mucous membrane |
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| CN101947342A true CN101947342A (en) | 2011-01-19 |
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| CN 201010270626 Pending CN101947342A (en) | 2010-09-02 | 2010-09-02 | Drug administrator, drug administration device and drug administration method for nasal cavity mucous membrane |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178997A (en) * | 2011-05-06 | 2011-09-14 | 吴成芳 | Earhole or nostril injector |
| CN104721941A (en) * | 2015-03-26 | 2015-06-24 | 江苏阳普医疗科技有限公司 | Adjustable stomach tube fixing device |
| CN109701128A (en) * | 2019-03-14 | 2019-05-03 | 邢朝阳 | It is adapted to the positive airway pressure air flue spray connector of finished product aerosol tubular nozzle |
| CN110314273A (en) * | 2019-07-09 | 2019-10-11 | 自贡市第四人民医院(自贡市急救中心) | A kind of supra-aural intranasal medicator and medication |
| CN110507896A (en) * | 2019-09-25 | 2019-11-29 | 中国人民解放军北部战区总医院 | A kind of two-chamber snuffing syringe |
| CN111888635A (en) * | 2020-08-03 | 2020-11-06 | 王慧 | Breathe clinical suction-type of internal medicine device of dosing |
| CN113925553A (en) * | 2021-09-29 | 2022-01-14 | 江苏旭原医疗科技有限公司 | Bronchus blocking device capable of reducing pain of patient |
| CN115300726A (en) * | 2022-01-14 | 2022-11-08 | 温州医科大学 | Special nasal delivery system and application method thereof |
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| US20020156420A1 (en) * | 2001-04-20 | 2002-10-24 | Anderson Mark L. | Fluid delivery cannula technology |
| CN1524001A (en) * | 2001-02-26 | 2004-08-25 | ���յ�ŵ˹��˾ | Nasal devices |
| US20090187098A1 (en) * | 2004-04-21 | 2009-07-23 | Acclarent, Inc. | Devices, Systems and Methods for Diagnosing and Treating Sinusitis and Other Disorders of the Ears, Nose, and/or Throat |
| CN201524345U (en) * | 2009-10-28 | 2010-07-14 | 武汉华纳联合药业有限公司 | Medicine feeder |
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2010
- 2010-09-02 CN CN 201010270626 patent/CN101947342A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1524001A (en) * | 2001-02-26 | 2004-08-25 | ���յ�ŵ˹��˾ | Nasal devices |
| US20020156420A1 (en) * | 2001-04-20 | 2002-10-24 | Anderson Mark L. | Fluid delivery cannula technology |
| US20090187098A1 (en) * | 2004-04-21 | 2009-07-23 | Acclarent, Inc. | Devices, Systems and Methods for Diagnosing and Treating Sinusitis and Other Disorders of the Ears, Nose, and/or Throat |
| CN201524345U (en) * | 2009-10-28 | 2010-07-14 | 武汉华纳联合药业有限公司 | Medicine feeder |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102178997A (en) * | 2011-05-06 | 2011-09-14 | 吴成芳 | Earhole or nostril injector |
| CN104721941A (en) * | 2015-03-26 | 2015-06-24 | 江苏阳普医疗科技有限公司 | Adjustable stomach tube fixing device |
| CN109701128A (en) * | 2019-03-14 | 2019-05-03 | 邢朝阳 | It is adapted to the positive airway pressure air flue spray connector of finished product aerosol tubular nozzle |
| CN110314273A (en) * | 2019-07-09 | 2019-10-11 | 自贡市第四人民医院(自贡市急救中心) | A kind of supra-aural intranasal medicator and medication |
| CN110507896A (en) * | 2019-09-25 | 2019-11-29 | 中国人民解放军北部战区总医院 | A kind of two-chamber snuffing syringe |
| CN111888635A (en) * | 2020-08-03 | 2020-11-06 | 王慧 | Breathe clinical suction-type of internal medicine device of dosing |
| CN111888635B (en) * | 2020-08-03 | 2022-12-23 | 王慧 | Breathe clinical suction-type of internal medicine device of dosing |
| CN113925553A (en) * | 2021-09-29 | 2022-01-14 | 江苏旭原医疗科技有限公司 | Bronchus blocking device capable of reducing pain of patient |
| CN113925553B (en) * | 2021-09-29 | 2023-11-17 | 江苏禾川医疗有限公司 | Bronchial blanking plug capable of reducing pain of patient |
| CN115300726A (en) * | 2022-01-14 | 2022-11-08 | 温州医科大学 | Special nasal delivery system and application method thereof |
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Application publication date: 20110119 |