CN101920072A - Intracavitary visible photodynamic therapeutic instrument - Google Patents
Intracavitary visible photodynamic therapeutic instrument Download PDFInfo
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- CN101920072A CN101920072A CN 201010275491 CN201010275491A CN101920072A CN 101920072 A CN101920072 A CN 101920072A CN 201010275491 CN201010275491 CN 201010275491 CN 201010275491 A CN201010275491 A CN 201010275491A CN 101920072 A CN101920072 A CN 101920072A
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- endoscope
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Abstract
The invention provides an intracavitary visible photodynamic therapeutic instrument. The instrument comprises an endoscope or inner endoscope, a laser light source and a laser conductive fiber, wherein one end of the laser conductive fiber is arranged in a cold light source channel of the endoscope, while the other end is connected with the laser light source; the endoscope or inner endoscope is one of a laparoscope, a joint endoscope, a thoracoscope or neuroendoscope, a gastroscope, a cystoscope and the like. The instrument realizes visible lighting in a body cavity by using the endoscope or inner endoscope, and introduces the laser light source to the lesion location in the body cavity so as to provide clear view for implementing gross resection surgeries, radiate by laser, and increase time for killing tumor cells. Furthermore, the instrument has small toxic or side effect, overcomes the defects of local cancer tissue invasion, lymph node metastasis, hematogenous metastasis, tumor cell detachment and implantation and the like which cannot be solved by chemotherapy, radiotherapy and other means. Based on application of photosensitizer, the actual range of a malignant lesions can be displayed, and 'target lesion' can be treated actively. The instrument has reasonable and simple structure, and can provide visible lighting in the body cavity to implement effective treatment on the 'target lesion'.
Description
Technical field
The invention discloses a kind of intracavity (abdominal cavity, thoracic cavity, articular cavity etc.) visible photodynamic therapeutic instrument, belong to technical field of medical instruments.
Background technology
Optical dynamic therapy is the method for the multiple malignant tumor of treatment (comprising various intracavitary neoplasms).The principle of photodynamic effect is a kind of by laser induced photochemical reaction.Photodynamic therapy is to utilize photosensitizer to be absorbed in a large number by cancerous tissue, and the very few characteristics that absorb of normal structure, the special laser irradiation cancerous protuberance of reuse, cancerous cell is destroyed and dead.Photosensitizer can selectivity accumulates, killing tumor cell specifically, and little to the health tissues infringement, toxicity is little, and favorable repeatability so optical dynamic therapy is very suitable for oldaged physically weak, can not performs the operation or the patient of intravenous chemotherapy, so more and more comes into one's own.
Because photodynamic therapy is a kind of topical therapeutic, the fragmentation effect of tumor is decided by to a great extent whether the illuminating dose of diseased region is abundant.Therefore, optical dynamic therapy must closely shine directly into patient part with the energy of laser, utilizes the combined effect of laser energy and photosensitizer, reaches the purpose of killing and wounding pathological tissues; Present photodynamic therapeutic instrument is mainly used in the position that patient part can observe directly, as diseases such as superficial tumor, dermatosis and infection.And for occurring in the body cavity, the sufferer as positions such as abdominal cavity, thoracic cavity, articular cavity, cranial cavities does not then possess the execution condition; This mainly is owing to the parcel of body wall (stomach wall, thoracic wall, joint capsule, skull etc.) stereome outside the chamber, makes the pathological changes of intracavity exist deeply, is in dark state; And existing photodynamic therapeutic instrument is because the defective that structural design exists, illumination and visual function can't be provided, therefore, even adopting the mode of Minimally Invasive Surgery delivers to the laser of photodynamic therapeutic instrument in the body cavity, also can't search out the accurate position of pathological tissues or organ, can't implement effectively treatment to pathological tissues or organ, even may cause damage normal structure or organ.
Along with industrial improvement of Manufacturing Technology, being fused to of related discipline carried out endoscope-assistant surgery and established solid foundation.The basic procedure of endoscope-assistant surgery is to use cold light source that illumination is provided, the image that utilization digital camera technology arrives lens shooting, conduct to signal processing system and be presented on the monitor in real time by optical fibers, the doctor carries out analytical judgment by shown image on the monitor screen to patient's state of an illness then, and the utilization special instrument undergos surgery.The chamber mirror that uses in the endoscope-assistant surgery can effectively provide endoceliac visual illumination, but the chamber mirror itself does not have the function of treatment or operation, must use special instrument to carry out treatment initiatively to target " target focus ".That is to say, must special instrument be delivered in " target focus " residing body cavity that could implement operative treatment, this can increase the wound to patient's body undoubtedly by other approach.
Summary of the invention
The objective of the invention is to overcome the deficiency of prior art and provide a kind of simple and reasonable, endoceliac real-time visual illumination both can be provided, can implement the effectively intracavitary visible photodynamic therapeutic instrument of treatment to " target focus " again.
Intracavitary visible photodynamic therapeutic instrument of the present invention is to adopt following proposal to realize: intracavitary visible photodynamic therapeutic instrument, comprise chamber mirror, LASER Light Source, laser conduction optical fiber, one end of described laser conduction optical fiber is arranged in the cold light source passage of described chamber mirror, and the other end links to each other with LASER Light Source.
Among the present invention, described chamber mirror is a kind of in peritoneoscope, articular cavity mirror, the thoracoscope.
The present invention is owing to adopt said structure, utilize the chamber mirror to realize to endoceliac visual illumination, simultaneously LASER Light Source is imported to diseased region in the body cavity, both can provide and implement the clear visual field of resection operation substantially, simultaneously, can carry out laser irradiation, increase the time of killing tumor cell, and toxic and side effects is little, has overcome by all indeterminable local cancerous tissue infiltration of means such as chemotherapy, radiotherapy, lymphatic metastasis, hematogenous metastasis, the tumor cell problems such as plantation that come off.
The present invention not only can be used for providing the visual field in abdominal cavity, pelvic cavity, thoracic cavity etc., also the light power light source that plays therapeutical effect can be imported abdominal cavity, pelvic cavity, thoracic cavity etc., meets clinical needs.The present invention enters in the body cavity light power light source by existing chamber lens head, when light power light source is provided, can also provide art open country clearly.
Use the present invention, utilize the characteristics of the special absorption photosensitizer of tumor tissues energy, adopt with the respective wavelength laser-induced fluorescence (LIF) of photosensitizer coupling and carry out medical diagnosis, can be used for diagnosing tumor, labelling in the auxiliary art, clear and definite excision extension.Therefore,, not only can reach purpose, can also demonstrate the true scope of pernicious focus, make the clinician purpose be arranged, targetedly carry out treatment initiatively at " target focus " except that the tumor irradiation based on using photosensitizer.
Light source of the present invention is by chamber lens head input body cavity.Unite two into one by light source and chamber mirror light-source system the light dynamical system, the patient can operation process in, Yi Bian carry out surgery operating removing tumor, Yi Bian carry out optical dynamic therapy.Use the present invention, make OPK light source import no longer difficulty, and illumination range only is confined to endoscope-assistant surgery zone (diseased region), side reaction is littler.The more important thing is that along with excision cardinal principle tumor, the OPK treatment degree of depth is also progressively deepened, tumor cell that come off, that may plant transfer is also killed by the light power mechanism in the art simultaneously, and the effect of operation is strengthened greatly, really reaches radical cure.
The present invention is based on the combination of chamber mirror surgery, photodynamic therapy, indication is wide, is suitable for the ancillary method as operative treatment, and what still play never only is assosting effect, might improve whole radical cure effect.
Description of drawings
Accompanying drawing 1 is structural representation of the present invention.
In the accompanying drawing: 1-chamber mirror, 2-LASER Light Source, 3-laser conduction optical fiber.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is described in further details.
Referring to accompanying drawing, intracavitary visible photodynamic therapeutic instrument of the present invention comprises chamber mirror 1, LASER Light Source 2, laser conduction optical fiber 3, is provided with lens 4, cold light source transmission line 5 in the described chamber mirror 1; One end of described laser conduction optical fiber 3 is arranged in the cold light source passage 4 of described chamber mirror 1, and the other end links to each other with LASER Light Source 2.
In the present embodiment, described chamber mirror 1 is a peritoneoscope.
When present embodiment uses, adopt Minimally Invasive Surgery on patient body, to cut out an aperture, then, present embodiment is inserted in the patient's body lumen by described aperture, connect the peritoneoscope cold light source, to throwing light in the body cavity, by the endoceliac situation of laparoscopic visualization, search out " target focus " after, restart LASER Light Source 2, laser carries out directly effectively active treatment by laser conduction optical fiber 3 to " target focus ", can cooperate other treatments such as operation simultaneously.
Claims (2)
1. intracavitary visible photodynamic therapeutic instrument comprises chamber mirror or scope, LASER Light Source, laser conduction optical fiber, and it is characterized in that: an end of described laser conduction optical fiber is arranged in the cold light source passage of described chamber mirror or scope, and the other end links to each other with LASER Light Source.
2. intracavitary visible photodynamic therapeutic instrument according to claim 1 is characterized in that: described chamber mirror or a kind of in peritoneoscope, articular cavity mirror, thoracoscope or nerve endoscope, gastroscope, the cystoscope.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010275491 CN101920072A (en) | 2010-09-08 | 2010-09-08 | Intracavitary visible photodynamic therapeutic instrument |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010275491 CN101920072A (en) | 2010-09-08 | 2010-09-08 | Intracavitary visible photodynamic therapeutic instrument |
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| CN101920072A true CN101920072A (en) | 2010-12-22 |
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| CN 201010275491 Pending CN101920072A (en) | 2010-09-08 | 2010-09-08 | Intracavitary visible photodynamic therapeutic instrument |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536355A (en) * | 2013-08-21 | 2014-01-29 | 熊力 | Tumor targeted non-destructive low-power laser multi-functional scalpel system |
| CN103829919A (en) * | 2014-03-11 | 2014-06-04 | 青岛市城阳区人民医院 | Portable cystoscope |
| CN109758674A (en) * | 2019-01-23 | 2019-05-17 | 武汉布润脑医学科技有限责任公司 | A kind of glioma diagnosing and treating apparatus |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1403062A (en) * | 2002-10-15 | 2003-03-19 | 中国人民解放军第二军医大学 | Laser ablation system to eliminate cancerous embolism inside blood vessel or bile duct |
| CN2834608Y (en) * | 2005-11-14 | 2006-11-08 | 王传金 | Radioactive particle implanter |
| CN101518674A (en) * | 2009-03-13 | 2009-09-02 | 深圳先进技术研究院 | Visualization photic stimulation system and visualization photic stimulation method |
| CN201799013U (en) * | 2010-09-08 | 2011-04-20 | 中南大学 | Intracavitary visible photodynamic therapeutic instrument |
-
2010
- 2010-09-08 CN CN 201010275491 patent/CN101920072A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1403062A (en) * | 2002-10-15 | 2003-03-19 | 中国人民解放军第二军医大学 | Laser ablation system to eliminate cancerous embolism inside blood vessel or bile duct |
| CN2834608Y (en) * | 2005-11-14 | 2006-11-08 | 王传金 | Radioactive particle implanter |
| CN101518674A (en) * | 2009-03-13 | 2009-09-02 | 深圳先进技术研究院 | Visualization photic stimulation system and visualization photic stimulation method |
| CN201799013U (en) * | 2010-09-08 | 2011-04-20 | 中南大学 | Intracavitary visible photodynamic therapeutic instrument |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536355A (en) * | 2013-08-21 | 2014-01-29 | 熊力 | Tumor targeted non-destructive low-power laser multi-functional scalpel system |
| CN103829919A (en) * | 2014-03-11 | 2014-06-04 | 青岛市城阳区人民医院 | Portable cystoscope |
| CN109758674A (en) * | 2019-01-23 | 2019-05-17 | 武汉布润脑医学科技有限责任公司 | A kind of glioma diagnosing and treating apparatus |
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Open date: 20101222 |