CN101769901B - Liquid phase chromatography data processing system based on FPGA - Google Patents
Liquid phase chromatography data processing system based on FPGA Download PDFInfo
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- CN101769901B CN101769901B CN2008101879608A CN200810187960A CN101769901B CN 101769901 B CN101769901 B CN 101769901B CN 2008101879608 A CN2008101879608 A CN 2008101879608A CN 200810187960 A CN200810187960 A CN 200810187960A CN 101769901 B CN101769901 B CN 101769901B
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Abstract
The invention discloses a liquid phase chromatography data processing system based on an FPGA, which comprises an A/D conversion module, an FPGA module, a signal protocol conversion module and a display module, wherein the A/D conversion module is used for receiving analog voltage signals output by a liquid phase chromatography instrument and converting the analog voltage signals into digital signals; the FPGA module preprocesses the received digital signals, generates digitalized finger print maps, then, carries out intelligentized operation on generated finger print map signals for obtaining assessing data of the medicine quality, and simultaneously outputs the operated and processed numerical value to the signal protocol conversion module in a mode of digital signals, the signal protocol conversion module correspondingly converts the digital signals transmitted by the FPGA module and transmits the converted signals into the display module, and the display module displays curves and quantity values of the received digital signals. Through using the FPGA module as the core of the system, the data preprocessing of the whole liquid phase chromatography finger print map and the Chinese medicine quality assessment process can be independently, smoothly and fast carried out on line.
Description
Technical field
The present invention relates to liquid phase chromatography data processing system, relate in particular to a kind of liquid phase chromatography data processing system based on FPGA.
Background technology
The effect of traditional Chinese medicine is the summary of Chinese nation's medical practice in several thousand.But for a long period; The curative effect of the homemade Chinese patent drug of part has received query in medical profession; Especially be main general hospital with the doctor trained in Western medicine, Chinese patent drug fails to obtain due trust, thereby its sale and use are affected; Influence the reputation of Chinese medicine to a certain extent, hindered the fast development of Chinese medicine industry.Tracing it to its cause, mainly is that stability, the homogeneity of Chinese medicine end product quality is not enough, causes curative effect unstable, inconsistent, indivedual medicines even can't confirm curative effect; And be to lack effective quality control method on the root to tcm product.The material base of herbal medicine efficacy is the chemical constitution of its contained complicacy; The traditional Chinese medicine fingerprint technology is the method that a kind of comprehensive evaluation embodies the contained material crowd of Chinese medicine of herbal medicine efficacy; Since the Chinese Pharmacopoeia council 2002 issue " traditional Chinese medicine chromatographic fingerprinting experimental study technical manual ", constantly the widening and go deep into of this area research, but we find that technological at present realization is merely the algorithm software bag; There is not the relevant hardware part; Need on the auxiliary work station of liquid chromatograph, move, be difficult in the on-the-spot use of Chinese medicine preparation, thereby any valuable comparison information can't be provided for important concocting process.
Summary of the invention
For solving above-mentioned middle problem and the defective that exists, the invention provides a kind of liquid phase chromatography data processing system based on FPGA.
The present invention realizes through following technical scheme:
A kind of liquid phase chromatography data processing system based on FPGA involved in the present invention comprises:
Mould/number conversion module, FPGA module, signaling protocol walk around module and display module, said
Mould/number conversion module receives the analog voltage signal that liquid chromatograph is exported, and converts its analog voltage signal into digital signal;
The FPGA module; Digital signal to receiving is carried out pre-service; And generate digitized finger-print; Then the finger-print signal that generates is carried out intelligent computing, obtain the assessment data of drug quality, simultaneously the numerical value after the calculation process is transferred to the signaling protocol modular converter with the form of digital signal;
The signaling protocol modular converter is changed the digital signal that the FPGA module is transmitted accordingly, and the signal after its conversion is transferred in the display module;
Display module carries out the digital signal that receives the demonstration of curve and value and stores mainframe memory simultaneously into.
Said system also comprises electric supply installation, and this electric supply installation presses outer Jie's electric main and convert 2 amperes into interior working direct current, and its electric current is flowed to total system.When said FPGA module is carried out the pre-service computing to digital signal, also comprise a filter processing and code device.It mainly is the serial mode according to signal that said FPGA module is carried out pre-service to digital signal; After taking time Recursive Filtering treating apparatus to realize the low-pass filtering treatment of signal; Get into code device and proofread and correct, eliminate the interference of outer bound pair signal according to the genetic algorithm realization standard diagram of hybrid coding and the retention time of collection of illustrative plates to be measured.Selection in the code device Genetic Algorithm with Hybrid Encoding, intersection and variation are changed into the algorithm of concurrent operation.It is 8～16 digital signal that mould/number conversion module converts voltage signal into resolution, follows the level conversion agreement of TTL to CMOS.Said signaling protocol modular converter converts Transistor-Transistor Logic level into the CMOS level, can be used for serial communication interface or parallel communication interface.
The beneficial effect of technical scheme provided by the invention is:
Because having adopted can oneself's control, the FPGA module of multidiameter delay operation and multichannel input, output pin is as the core of system, the data pre-service of whole medicine inspection and drug quality evaluation process can be independent, online, smooth and carry out apace.
Description of drawings
Fig. 1 is based on the liquid phase chromatography data processing system structural drawing of FPGA.
Embodiment
For making the object of the invention, technical scheme and advantage clearer, will combine accompanying drawing that embodiment of the present invention is done to describe in detail further below:
Present embodiment provides a kind of liquid phase chromatography data processing system structure based on FPGA.
Referring to Fig. 1; This system architecture mainly comprises electric supply installation 10, mould/number conversion module 20, FPGA module 30, signaling protocol modular converter 40 and display module 50, in the said electric supply installation 10, supplies power to total system through power supply; The power bracket of this power supply is 1～10 watt; External 220 volts of electric mains are pressed, and working current is in 2 amperes, and its amplitude of fluctuation is remained on ± 0.5% in.Said mould/number conversion module 20 is that to convert resolution to be 8～16 for 1～80 minute, the voltage signal of amplitude in 0～3 volt range with the duration scope; Signaling protocol is TTL (Time To Live; Life span)/digital signal of CMOS (ComplementaryMetal-Oxide Semiconductor, complementary metal oxide semiconductor (CMOS)); Receive the TTL/CMOS digital signal by FPGA module 30 then; And its signal is carried out pre-service generate digitized finger-print; Then the finger-print signal that generates is carried out intelligent computing; Obtain the assessment data of drug quality, simultaneously the numerical value after the calculation process is transported to signaling protocol modular converter 40 with the form of digital signal; When 30 pairs of digital signals of said FPGA module are carried out the pre-service computing; Said FPGA module 30 also comprises a filter processing 301 and code device 302 in the digital signal preprocessing process; It mainly is the serial mode according to signal that 30 pairs of digital signals of said FPGA module are carried out pre-service; After taking time Recursive Filtering treating apparatus 301 to realize the low-pass filtering treatment of signal; Get into code device 302 and proofread and correct, eliminate the interference of outer bound pair signal according to the genetic algorithm realization standard diagram of hybrid coding and the retention time of collection of illustrative plates to be measured.But selection, intersection and variation in said code device 302 Genetic Algorithm with Hybrid Encoding will change the algorithm of concurrent operation into.Said FPGA module 30 capacity be 400,000 more than, receive the TTL/CMOS digital signal, required supply voltage is 1～5 volt of direct current scope, power bracket is 0.3～5 watt.
The digital signal that said signaling protocol modular converter 40 is transmitted FPGA module 30 is changed accordingly, and the signal after its conversion is transferred in the display module 50 and is stored by PC storer 60 simultaneously; The said signaling protocol modular converter 40 main RS232 signaling protocol converters that adopt; Convert the TTL/CMOS protocol signal of upper level to the RS232 protocol signal by RS232 signaling protocol converter; And signal conveys shown through LCD display to the PC main frame; This display WV is 3～10 volts of direct currents, and shows the curve and the value of the digital signal that receives.
The above; Be merely the preferable embodiment of the present invention, but protection scope of the present invention is not limited thereto, any technician who is familiar with the present technique field is in the technical scope that the present invention discloses; The variation that can expect easily or replacement all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claim.
Claims (5)
1. based on the liquid phase chromatography data processing system of FPGA, it is characterized in that, comprise mould/number conversion module, FPGA module, signaling protocol walk around module and display module, said
Mould/number conversion module receives the analog voltage signal that liquid chromatograph is exported, and converts its analog voltage signal into digital signal;
The FPGA module; Digital signal to receiving is carried out pre-service; And generate digitized finger-print; Then the finger-print signal that generates is carried out intelligent computing, obtain the assessment data of drug quality, simultaneously the numerical value after the calculation process is transferred to the signaling protocol modular converter with the form of digital signal;
The signaling protocol modular converter is changed the digital signal that the FPGA module is transmitted accordingly, and the signal after its conversion is transferred in the display module;
Display module carries out the digital signal that receives the demonstration of curve and value and stores mainframe memory simultaneously into.
2. according to the said liquid phase chromatography data processing system of claim 1 based on FPGA; It is characterized in that; Said system also comprises electric supply installation, and this electric supply installation presses extraneous electric main and convert 2 amperes into interior working direct current, and its electric current is flowed to total system.
3. the liquid phase chromatography data processing system based on FPGA according to claim 1 is characterized in that, when said FPGA module is carried out the pre-service computing to digital signal, also comprises a filter processing and code device.
4. according to claim 1 or 3 said liquid phase chromatography data processing systems based on FPGA; It is characterized in that; It mainly is the serial mode according to signal that said FPGA module is carried out pre-service to digital signal; After taking time Recursive Filtering treating apparatus to realize the low-pass filtering treatment of signal, get into code device and proofread and correct according to the genetic algorithm realization standard diagram of hybrid coding and the retention time of collection of illustrative plates to be measured, eliminate the interference of outer bound pair signal.
5. the liquid phase chromatography data processing system based on FPGA according to claim 4 is characterized in that, the selection in the code device Genetic Algorithm with Hybrid Encoding, intersection and variation is changed into the algorithm of concurrent operation.
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| CN2008101879608A CN101769901B (en) | 2008-12-31 | 2008-12-31 | Liquid phase chromatography data processing system based on FPGA |
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| CN2008101879608A CN101769901B (en) | 2008-12-31 | 2008-12-31 | Liquid phase chromatography data processing system based on FPGA |
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| CN101769901B true CN101769901B (en) | 2012-07-04 |
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| CN109413066A (en) * | 2018-10-26 | 2019-03-01 | 雪普达分析仪器(天津)有限公司 | Communication protocol converter of analytical instrument |
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| CN101274234A (en) * | 2006-12-30 | 2008-10-01 | 亚申科技研发中心（上海）有限公司 | Substance processing equipment |
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Patent Citations (6)
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| WO2004068523A2 (en) * | 2003-01-24 | 2004-08-12 | Thermo Finnigan Llc | Controlling ion populations in a mass analyzer |
| WO2006002027A2 (en) * | 2004-06-15 | 2006-01-05 | Griffin Analytical Technologies, Inc. | Portable mass spectrometer configured to perform multidimensional mass analysis |
| CN1710422A (en) * | 2004-06-18 | 2005-12-21 | 安捷伦科技有限公司 | Electronically controlled back pressure regulator |
| WO2006116564A2 (en) * | 2005-04-25 | 2006-11-02 | Griffin Analytical Technologies, L.L.C. | Analytical instrumentation, appartuses, and methods |
| CN101210913A (en) * | 2006-12-30 | 2008-07-02 | 亚申科技研发中心（上海）有限公司 | Substance quantitative analysis method |
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