CN101711683A - Method for measuring flow velocity of arterial blood - Google Patents
Method for measuring flow velocity of arterial blood Download PDFInfo
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- CN101711683A CN101711683A CN 200910191276 CN200910191276A CN101711683A CN 101711683 A CN101711683 A CN 101711683A CN 200910191276 CN200910191276 CN 200910191276 CN 200910191276 A CN200910191276 A CN 200910191276A CN 101711683 A CN101711683 A CN 101711683A
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- 210000004369 blood Anatomy 0.000 title claims abstract description 26
- 239000008280 blood Substances 0.000 title claims abstract description 26
- 238000000034 method Methods 0.000 title claims abstract description 17
- 239000002872 contrast media Substances 0.000 claims abstract description 36
- 210000001367 artery Anatomy 0.000 claims abstract description 26
- 230000017531 blood circulation Effects 0.000 claims abstract description 19
- 210000003462 vein Anatomy 0.000 claims abstract description 10
- 238000005259 measurement Methods 0.000 claims abstract description 9
- 238000013170 computed tomography imaging Methods 0.000 claims abstract description 8
- 230000010412 perfusion Effects 0.000 claims description 4
- 230000006798 recombination Effects 0.000 claims description 4
- 238000005215 recombination Methods 0.000 claims description 4
- 238000004458 analytical method Methods 0.000 claims description 3
- 210000004204 blood vessel Anatomy 0.000 abstract description 13
- 238000003384 imaging method Methods 0.000 abstract description 6
- 238000005070 sampling Methods 0.000 abstract description 3
- 230000002792 vascular Effects 0.000 abstract description 2
- 210000001105 femoral artery Anatomy 0.000 description 7
- 238000002347 injection Methods 0.000 description 7
- 239000007924 injection Substances 0.000 description 7
- 238000002604 ultrasonography Methods 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 238000002591 computed tomography Methods 0.000 description 3
- 208000031481 Pathologic Constriction Diseases 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 206010060965 Arterial stenosis Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 206010037714 Quadriplegia Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 210000003677 hemocyte Anatomy 0.000 description 1
- 229940000351 hemocyte Drugs 0.000 description 1
- 210000004394 hip joint Anatomy 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 230000002969 morbid Effects 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 210000004417 patella Anatomy 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 230000036262 stenosis Effects 0.000 description 1
- 208000037804 stenosis Diseases 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- 210000001364 upper extremity Anatomy 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
- A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
- A61B6/507—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for determination of haemodynamic parameters, e.g. perfusion CT
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- High Energy & Nuclear Physics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dentistry (AREA)
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- Radiology & Medical Imaging (AREA)
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Abstract
The invention discloses a method for measuring the flow velocity of arterial blood, which is based on a spiral CT imaging system. The method comprises the steps of: injecting a proper amount of contrast agent into a vein first (the contrast agent reaches an artery through blood circulation), selecting a section of target blood vessel, scanning and tracking the contrast agent at the starting point and the end point respectively to acquire an image in which the contrast agent appears first at the starting point and another image in which the contrast agent appears first at the end point, and calculating the difference of two times, namely the flowing time of blood in the section of blood vessel according to the automatically recorded scanning times on the images; and then performing vascular imaging on the target blood vessel section of the artery, straightening the target blood vessel section of the artery by using software carried by a CT machine, and measuring the actual length of the section of blood vessel. The ratio of the actual length of the section of blood vessel to the flowing time of the blood of the section of blood vessel from the starting point to the end point is the flow velocity of the arterial blood. Compared with the measurement of the flow velocity of the blood by ultrasonic Doppler, the method for measuring the flow velocity of the arterial blood gets rid of the limitation on angle, sampling volume and the like, has broader applicable range, and ensures the accuracy.
Description
Technical field
The present invention relates to a kind of method of measuring flow velocity of arterial blood, especially a kind of method of measuring flow velocity of arterial blood based on the spiral CT imaging system.
Background technology
Velocity of blood flow is meant hemocyte and the liquid flowing velocity in blood vessel.Hyperlipidemia, flow velocity slows down, and lipid just is deposited on the inwall of blood vessel in the blood, causes luminal stenosis, blood supply insufficiency.As coronary stricture, cause myocardial ischemia or myocardial infarction, threat to life; Cerebral arterial stenosis causes cerebral infarction, quadriplegia that infarct area is arranged; Limb artery is narrow, causes narrow far-end limb function to weaken or muscular death.Human body is under kinestate, resting state or morbid state, and its arterial blood flowing velocity is inequality.By measuring the arterial blood flowing velocity, understand its Changing Pattern, grasp range of normal value, maximum and the minima of arterial blood flowing velocity, for the health status of our researching human body organ and the dependency of flow velocity of arterial blood, and prevent various cardiovascular disease that great importance is arranged.
The ultrasonic multispectral technology of reining in is to utilize ultrasound wave to survey velocity of blood flow, and after running into moving object (as cell), the phenomenon of skew takes place its supersonic frequency according to ultrasound wave, measures the vessel inner blood flow velocity.During continuous ultrasound Doppler measurement velocity of blood flow, its result is subjected to the influence of acoustic beam and direction of motion angle bigger, can't understand the generation position of abnormal blood flow; During pulse ultrasonic wave Doppler measurement velocity of blood flow, the size of its blood flow rate of surveying is the restriction that the Doppler frequency shift size is subjected to pulse recurrence frequency, when its frequency shift value surpasses Nyquist frequency, fast blood flow spike part can not normally show, the developing of frequency of occurrences perversion, accuracy of measurement can not guarantee.In addition, because the sampling volume scope is little, need move repeatedly on section, detection time is longer.So use ultrasound Doppler's method to measure the restriction that velocity of blood flow is subjected to head angle, sampling volume etc., the scope of application is little.
Summary of the invention
It is guaranteed and can be applicable to the measuring method of the flow velocity of arterial blood of different parts that the technical problem to be solved in the present invention provides a kind of accuracy.The technical solution adopted in the present invention is based on the spiral CT imaging system, may further comprise the steps:
(1) inject an amount of contrast medium for the first time in human vein, contrast medium arrives the arteries target phase by blood circulation;
(2) with CT the starting point of arteries target phase is carried out spotting scaming, obtain the image that contrast medium at first arrives starting point, promptly obtain first time point t
1, CT carries out perfusion scanning to terminal point automatically, obtains the image that contrast medium is at first reached home, and promptly obtains second time point t
2
(3) in human vein, inject contrast medium for the second time, when contrast medium when the arteries target phase reaches suitable concentration, with CT this arteries target phase is carried out helical scanning, realize the three-dimensional reconstruction of arteries target phase, the curved surface recombination function of the analysis to measure software that carries with CT is stretching and measure the length s of target phase with this target phase;
(4) two time point t
2With t
1Poor, be selected arteries target phase from the origin-to-destination blood flow time, s is the physical length of selected arteries target phase from origin-to-destination, goes out the blood mean flow rate v of arteries target phase by above-mentioned data computation, that is:
Comparatively concentrated for the contrast medium that makes injection, realize effect clearly during scanning, further limit in the above step when in human vein, injecting contrast medium twice, all adopt high pressure injector.The high pressure injector injection speed is fast, and control is convenient.
Those skilled in the art are not difficult to learn, inject an amount of contrast medium in the above step for the first time in human vein, generally inject about 10 milliliters, are applicable to the spotting scaming imaging and the perfusion scanning imaging of CT imaging.For the second time in human vein, inject contrast medium, generally inject about 80 milliliters, reach higher concentration, be applicable to the three-dimensional reconstruction technology of CT imaging.Starting point and terminal point in the target blood section are measured the time point that contrast medium arrives, and all can show on the CT picture.Two time points poor is exactly the flowing time of this section vessel inner blood, and the measurement of two time points is directly perceived, convenient.CT scan is transverse section scanning, and the distance between two imaging planes is only represented the vertical dimension between the starting point plane of scanning motion and the terminal point plane of scanning motion.Since the complexity of organization of human body, arteries traveling polytropy, and physical length generally can be greater than this vertical dimension.And when utilizing the present invention to measure flow velocity of arterial blood, the length of selected arteries target phase is not simply to represent with the distance between starting point and terminal point, but will carry out CT scan from this section blood vessel of origin-to-destination and carry out three-dimensional imaging, the curved surface recombination function that the analysis to measure software that application CT carries is provided, its length is measured in the stretching back of this section blood vessel, this length is only the physical length of selected arteries target phase, has guaranteed the accuracy of measuring.
According to the above data of surveying, calculate the physical length and the ratio of this section blood vessel of the arteries target phase of surveying from the origin-to-destination flowing time, be the average flow velocity of this arteries target phase inner blood.
This method based on spiral CT imaging system measurement flow velocity of arterial blood is compared the ultrasonic doppler measurements blood flow velocity, has broken away from restrictions such as angle, sample volume, and the scope of application is wider.This method can show desired data when calculating velocity of blood flow intuitively and easily based on modern imaging device, and accuracy is guaranteed.
The specific embodiment
To measure human body femoral artery velocity of blood flow is example, further explains the present invention.
CT scan is used SIEMENS SOMATOM Definition double source CT machine, the STELLANT type Binocular High-pressure Syringe that syringe uses U.S. MeoRao company to produce, and contrast medium uses iodine than happy nonionic, and concentration is 370mgI/ml.Its measuring process is as follows: at first, the measured is lain on the back on examinating couch, and both hands are lifted over the top of the head, places comfortablely, is ready to contrast medium, normal saline, connects high pressure injector, and mobile examinating couch carries out thigh location picture and scans to scanning position.Go up from anterior superior iliac spine, down to the tibia upper end, starting point is selected in plane on the hip joint, and terminal point is selected in the patella lower plane.Then, from upper limb ancon puncture vein, the injection speed of high pressure injector is 4ml/s, and contrast medium total amount 10ml is after contrast medium injection finishes, with the fast injecting normal saline 20ml (step 1) in the corresponding summary of the invention.Contrast medium arrives the arteries target phase needs the regular hour, in order to make the least possible radiation that is subjected to X ray in the CT imaging of patient, begin to clock from injection of contrast agent, postpone to begin the starting point spotting scaming in 12 seconds, starting point is with CT spotting scaming sequence, after obtaining contrast medium and at first arriving the image of starting point, the CT machine position of reaching home automatically, begin the terminal point perfusion scanning, observe scanogram, when contrast medium is reached home, stop scanning (step 2 in the corresponding summary of the invention).After stopping scanning, re-inject contrast medium, total amount 80ml, after contrast medium injection finishes, with fast injecting normal saline 50ml, pick up counting from injection, postpone 12 seconds spotting scamings, behind the arrival trigger value 130Hu, automatically perform the lower limb scanning sequence, from the omnidistance to terminal helical scanning of starting point, rebuild the bed thickness 1mm thin layer sequence image of 0.5mm at interval, row femoral artery three-dimensional reconstruction in the poster processing soft, use the curved surface recombination function, blood vessel is stretching, and measure its length, this length is exactly true length (the step 3) corresponding summary of the invention of femoral artery from origin-to-destination.
Two width of cloth images that contrast medium at first arrives starting point and at first reaches home, the scanning that all indicates image are constantly calculated two scannings blanking times constantly, are the blood flow time of femoral artery from origin-to-destination.At last, calculate measured femoral artery, promptly obtain the average blood flowing velocity (step 4) in the corresponding summary of the invention of femoral artery from the true length of origin-to-destination and measured femoral artery ratio from the blood flow time of origin-to-destination.
This is one embodiment of the present invention, under the situation that does not break away from technical solution of the present invention, can change details in the implementation process or implementation condition,, but not influence essence creativeness of the present invention such as the concentration of contrast medium, the method for injecting contrast medium, the vascular site of measurement etc.
Claims (2)
1. a method of measuring flow velocity of arterial blood is characterized in that, this method may further comprise the steps based on the spiral CT imaging system:
(1) inject an amount of contrast medium for the first time in human vein, contrast medium arrives the arteries target phase by blood circulation;
(2) with CT the starting point of arteries target phase is carried out spotting scaming, obtain the image that contrast medium at first arrives starting point, promptly obtain first time point t
1, CT carries out perfusion scanning to terminal point automatically, obtains the image that contrast medium is at first reached home, and promptly obtains second time point t
2
(3) in human vein, inject contrast medium for the second time, when contrast medium when the arteries target phase reaches suitable concentration, with CT this arteries target phase is carried out helical scanning, realize the three-dimensional reconstruction of arteries target phase, the curved surface recombination function of the analysis to measure software that carries with CT is stretching and measure the length s of target phase with this target phase;
(4) two time point t
2With t
1Poor, be selected arteries target phase from the origin-to-destination blood flow time, s is the physical length of selected arteries target phase from origin-to-destination, goes out the blood mean flow rate v of arteries target phase by above-mentioned data computation, that is:
2. the method for measurement flow velocity of arterial blood as claimed in claim 1 is characterized in that: all adopt high pressure injector when injecting contrast medium for the first time and for the second time in human vein in the described step.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200910191276 CN101711683A (en) | 2009-10-30 | 2009-10-30 | Method for measuring flow velocity of arterial blood |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200910191276 CN101711683A (en) | 2009-10-30 | 2009-10-30 | Method for measuring flow velocity of arterial blood |
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| CN101711683A true CN101711683A (en) | 2010-05-26 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106419890A (en) * | 2016-11-14 | 2017-02-22 | 佛山科学技术学院 | Blood speed measuring device and method based on space-time modulation |
| US9999401B2 (en) | 2015-02-27 | 2018-06-19 | Siemens Aktiengesellschaft | Determining the velocity of a fluid with the aid of an imaging method |
| CN109512450A (en) * | 2018-10-18 | 2019-03-26 | 深圳市孙逸仙心血管医院（深圳市心血管病研究所） | The method for measuring vascular flow speed |
| CN110772275A (en) * | 2019-11-05 | 2020-02-11 | 上海联影医疗科技有限公司 | CT scanning method, device and system based on ultrasound |
| CN112584770A (en) * | 2018-06-06 | 2021-03-30 | 开迪恩有限公司 | Method for determining a flow rate of a fluid flowing through an implantable vascular support system and implantable vascular support system |
| WO2023130197A1 (en) * | 2022-01-04 | 2023-07-13 | Shenzhen Xpectvision Technology Co., Ltd. | Flow speed measurements using imaging systems |
-
2009
- 2009-10-30 CN CN 200910191276 patent/CN101711683A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9999401B2 (en) | 2015-02-27 | 2018-06-19 | Siemens Aktiengesellschaft | Determining the velocity of a fluid with the aid of an imaging method |
| CN106419890A (en) * | 2016-11-14 | 2017-02-22 | 佛山科学技术学院 | Blood speed measuring device and method based on space-time modulation |
| CN106419890B (en) * | 2016-11-14 | 2024-04-30 | 佛山科学技术学院 | Blood flow velocity measuring device and method based on space-time modulation |
| CN112584770A (en) * | 2018-06-06 | 2021-03-30 | 开迪恩有限公司 | Method for determining a flow rate of a fluid flowing through an implantable vascular support system and implantable vascular support system |
| CN109512450A (en) * | 2018-10-18 | 2019-03-26 | 深圳市孙逸仙心血管医院（深圳市心血管病研究所） | The method for measuring vascular flow speed |
| CN110772275A (en) * | 2019-11-05 | 2020-02-11 | 上海联影医疗科技有限公司 | CT scanning method, device and system based on ultrasound |
| CN110772275B (en) * | 2019-11-05 | 2023-08-15 | 上海联影医疗科技股份有限公司 | CT scanning method, device and system based on ultrasound |
| WO2023130197A1 (en) * | 2022-01-04 | 2023-07-13 | Shenzhen Xpectvision Technology Co., Ltd. | Flow speed measurements using imaging systems |
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Application publication date: 20100526 |