CN101700349A - Liquid hard capsule of Anagex extract and preparation method thereof - Google Patents
Liquid hard capsule of Anagex extract and preparation method thereof Download PDFInfo
- Publication number
- CN101700349A CN101700349A CN200810147655A CN200810147655A CN101700349A CN 101700349 A CN101700349 A CN 101700349A CN 200810147655 A CN200810147655 A CN 200810147655A CN 200810147655 A CN200810147655 A CN 200810147655A CN 101700349 A CN101700349 A CN 101700349A
- Authority
- CN
- China
- Prior art keywords
- preparation
- hard capsule
- extracting solution
- anagex
- liquid hard
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention relates to the field of pharmacy, mainly relating to a preparation method of a liquid hard capsule of traditional Chinese materia medica preparation, in particular to the liquid hard capsule of Anagex extract and a preparation method thereof. In the invention, the content object filled in the capsule is a mixed liquid type object comprising the following materials in proportion, 10-80 percent of Anagex extract, 10-80 percent of edible oil, and 1-40 percent of a surface active agent.
Description
Technical field
The present invention relates to pharmaceutical field, relate generally to the liquid hard capsule preparation method of Chinese traditional patent formulation preparation, be specially liquid hard capsule of Anagex extract and preparation method thereof.
Background technology
Existing one-tenth side Maiwei-dihuang preparation mainly is Maiwei rehmannia-root oral liquid, MAIWEIDIHUANGPIAN, MAIWEIDIHUANGWAN etc. on the market, solid oral dosage forms such as the pill of this prescribed preparation of employing routine techniques preparation, tablet, granule, complex manufacturing, drug effect runs off serious, and oral solutions is taken problem such as inconvenience and usually occurred.
Summary of the invention
The present invention is directed to above-mentioned problem, invent and a kind ofly have the drug effect height, take liquid hard capsule of Anagex extract convenient, convenient for production, it possesses nourishing kidney and supports the lung effect, can be used for the treatment of hectic fever night sweat, dry pharynx, vertigo and tinnitus, soreness of the waist and knees.
The concrete technical scheme of the present invention is as follows:
Liquid hard capsule of Anagex extract and preparation method thereof, the content of this capsule fill is the mixing fraction that extracting solution, edible oil, the surfactant of Maiwei-dihuang formed, and its ratio is: extracting solution 10～80%, edible oil 10～80%, surfactant 1～40%.
Liquid hard capsule of Anagex extract and preparation method thereof may further comprise the steps:
The outfit of a, medical material: according to the recipe quantity ratio of Chinese traditional patent formulation preparation Maiwei-dihuang, take by weighing eight flavor Chinese crude drugs such as Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Rehmanniae Preparata, Fructus Corni (system), Cortex Moutan, Rhizoma Dioscoreae, membrane inside the rush stalk Siberian cocklebur, Rhizoma Alismatis, its ratio is: 45 parts of Radix Ophiopogonis, 30 parts of Fructus Schisandrae Chinensis, 120 parts of Radix Rehmanniae Preparata, 60 parts of Fructus Corni (system), 45 parts of Cortex Moutans, 60 parts of Rhizoma Dioscoreaes, 45 parts of membrane inside the rush stalk Siberian cockleburs, 45 parts of Rhizoma Alismatis;
The extraction of b, medicament: the medical material that a set by step is equipped with adopts traditional water decocting method to extract, and will above eight flavor Chinese crude drugs adds water boil and extracts twice, filters and merges the decoction extracting solution twice;
Concentrating of c, medicament: the extracting solution of b set by step further is condensed into thick paste, obtains the concentrated extracting solution that active substance of the present invention is a Maiwei-dihuang;
The emulsifying of d, medicine: concentrated extracting solution that step c is obtained and the edible oil that contains surfactant mix at a certain temperature and carry out emulsifying, can obtain a kind of water in oil emulsus mixed solution;
The fill of e, medicament: the water in oil emulsus mixed solution that steps d is obtained is filled to by the liquid capsule filling machine that the blended rubber bar seals in the hollow liquid hard capsule, prepares liquid hard capsule of Anagex extract of the present invention.
The extracting solution of Maiwei-dihuang can be the extracting solution of water as the solvent preparation, also can be the extracting solution of ethanol as the solvent preparation, and preferred water is as the extracting solution of solvent preparation.
Edible oil, preferred Oleum Gossypii semen or Oleum Cocois or Oleum Arachidis hypogaeae semen or hydrogenated groundnut or Petiolus Trachycarpi oil or hydrogenated palm oil or soybean oil.
Surfactant, preferred single caprylin or glyceryl monolaurate or propylene glycol stearate or glyceryl monostearate or Arlacel-80 or Arlacel-60.
The method for concentration of Maiwei-dihuang decoction liquor is concentrating under reduced pressure or membrance concentration, and vacuum distillation temperature will hang down more than 30 degree than air-distillation usually, and membrance concentration is that the mode that makes aqueous solution pass through film filter filtering moisture concentrates, and this process is operated at normal temperatures.
The advantage of the liquid hard capsule of Maiwei-dihuang has:
(1) the overall volume size is with common capsule and can directly swallow, and oral liquid is to need fill every dose of specification is big and also need or open bottle cap by means of suction pipe when drinking relatively in bottle, and liquid hard capsule is better than oral solutions on the convenience from taking;
(2) pill, tablet, the decoction liquor that solid oral dosage forms such as granule need to have extracted the medical material effective ingredient in the preparation heats dewatered process by high temperature and is dried to solid, thereby the high temperature heating unavoidably can cause the part loss of active ingredients to reduce drug effect in this solidification process, taking the back solids content need could be utilized by human body after the dissolving in human consumption liquid again, owing to can not reach complete stripping usually, also can lose the part drug effect, the liquid hard capsule content itself be liquid in the preparation without the solidification process kimonos time spent need be in human consumption liquid course of dissolution again, thereby avoided the drug effect loss in these two processes, liquid hard capsule is better than pill on the drug effect, tablet, solid oral dosage forms such as granule;
(3) in the fill production process, liquid hard capsule is liquid contents to be sealed at once by the commercially available Capsules of the direct injection of capsule filling machine finish, soft capsule is content to be injected the on-the-spot compacting of homemade gelatin skin by pellet press form, need before the soft capsule compacting by changing glue, colloidal sol, remove steam bubble, insulation, process in situ preparations such as rubber molding go out the gelatin skin, also need after the soft capsule compacting through the soft gelatin capsule typing, wash ball, dry, select the ball supervisor to handle together, the complicated cycle of soft capsule whole process of production control is long, and liquid hard capsule is better than soft capsule on the property convenient for production;
(4) the liquid oral hard capsule need dissolve in gastro-intestinal Fluid, capsule shells is with regard to the tool water solublity, it is water-insoluble liquid that content just necessarily requires, the commercially available prod is the liquid hard capsule of water-insoluble oils product, what leaching process all adopted in the side's of one-tenth Maiwei-dihuang method for making is that traditional water decocts, its extracting solution is that aqueous solution just can dissolve capsule shells, so can not directly be filled in the capsule, utilize water in oil emulsifying technology, the aqueous solution that extracts and edible oil emulsifying are together just obtained a kind of emulsion of edible oil package pickup aqueous solution, this emulsion surface has oily feature can not dissolve capsule shells, just can be filled in the capsule, thereby prepare the Maiwei-dihuang liquid hard.
The present invention compared with prior art has following characteristics:
The content active substance of the liquid hard capsule of Maiwei-dihuang of the present invention belongs to liquid solution for its extracting solution, kind of liquid when taking is because its effective ingredient is to be dissolved in the solution, have that human body easily absorbs, rapid-action, release fully waits characteristics, its drug effect is higher than solid dosage forms.The liquid hard capsule of Maiwei-dihuang is with respect to its oral solutions, is all liquid dosage form, with the high characteristics of tool drug effect, but use go up convenient.The liquid hard capsule overall volume size of Maiwei-dihuang is with common capsule and can directly swallow, and oral liquid is to need fill in bottle, every dose of specification is more portable and also need or open bottle cap by means of suction pipe when drinking relatively, and liquid hard capsule is better than oral solutions on the convenience from taking.
The liquid hard capsule of Maiwei-dihuang is with respect to solid oral dosage forms such as the pill of Maiwei-dihuang, tablet, granules, thereby the shortening of manufacture process has reduced loss of active ingredients in manufacture process, the CL attitude has been avoided dissolving the part medicine that not exclusively causes again and has not been utilized by human body when taking, have higher effective ingredient and human body availability.Pill, tablet, the decoction liquor that solid oral dosage forms such as granule need to have extracted the medical material effective ingredient in the preparation heats dewatered process by high temperature and is dried to solid, thereby the high temperature heating unavoidably can cause the part loss of active ingredients to reduce drug effect in this solidification process, taking the back solids content need could be utilized by human body after the dissolving in human consumption liquid again, owing to can not reach complete stripping usually, also can lose the part drug effect, the liquid hard capsule content itself be liquid in the preparation without the solidification process kimonos time spent need be in human consumption liquid course of dissolution again, thereby avoided the drug effect loss of these two middle processes, liquid hard capsule is better than pill on the drug effect, tablet, solid oral dosage forms such as granule.
The liquid hard capsule of Maiwei-dihuang is with respect to the soft capsule of Maiwei-dihuang, and pouring process only need pour into and seal, and process is simple, output is big, with short production cycle, is more suitable for large-scale industrial production.In the fill production process, liquid hard capsule is liquid contents to be sealed at once by the commercially available Capsules of the direct injection of capsule filling machine finish, soft capsule is content to be injected the on-the-spot compacting of homemade gelatin skin by pellet press form, need before the soft capsule compacting by changing glue, colloidal sol, remove steam bubble, insulation, process in situ preparations such as rubber molding go out the gelatin skin, also need after the soft capsule compacting through the soft gelatin capsule typing, wash ball, dry, select the ball supervisor to handle together, the complicated cycle of soft capsule whole process of production control is long, and liquid hard capsule is better than soft capsule on the property convenient for production.
Liquid hard capsule of Anagex extract is with respect to the liquid oral hard capsule of common in the market oils product, and its active content is an aqueous solution, has broken through the normally limitation of oils solution of liquid hard capsule content.The liquid oral hard capsule need dissolve in gastro-intestinal Fluid, capsule shells is with regard to the tool water solublity, it is water-insoluble liquid that content just necessarily requires, the commercially available prod is the liquid hard capsule of water-insoluble oils product, what leaching process all adopted in the side's of one-tenth Maiwei-dihuang method for making is that traditional water decocts, its extracting solution is that aqueous solution just can dissolve capsule shells, so can not directly be filled in the capsule, utilize water in oil emulsifying technology, the aqueous solution that extracts and edible oil emulsifying are together just obtained a kind of emulsion of edible oil package pickup aqueous solution, this emulsion surface has oily feature can not dissolve capsule shells, just can be filled in the capsule, thereby prepare the Maiwei-dihuang liquid hard.
The specific embodiment
Liquid hard capsule of Anagex extract and preparation method thereof, the content of this capsule fill is the mixing fraction that extracting solution, edible oil, the surfactant of Maiwei-dihuang formed, and its ratio is: extracting solution 10～80%, edible oil 10～80%, surfactant 1～40%.
Liquid hard capsule of Anagex extract and preparation method thereof may further comprise the steps:
The outfit of a, medical material: according to the recipe quantity ratio of Chinese traditional patent formulation preparation Maiwei-dihuang, take by weighing eight flavor Chinese crude drugs such as Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, membrane inside the rush stalk Siberian cocklebur, Rhizoma Alismatis, its ratio is: 45 parts of Radix Ophiopogonis, 30 parts of Fructus Schisandrae Chinensis, 120 parts of Radix Rehmanniae Preparata, 60 parts of Fructus Corni (system), 45 parts of Cortex Moutans, 60 parts of Rhizoma Dioscoreaes, 45 parts of membrane inside the rush stalk Siberian cockleburs, 45 parts of Rhizoma Alismatis;
The extraction of b, medicament: a set by step join by medical material adopt traditional water decocting method to extract, will above eight flavor Chinese crude drugs add water boil and extract twice, filter and merge the decoction extracting solution twice;
Concentrating of c, medicament: the extracting solution of b set by step further is condensed into thick paste, obtains the concentrated extracting solution that active substance of the present invention is a Maiwei-dihuang;
The emulsifying of d, medicine: concentrated extracting solution that step c is obtained and the edible oil that contains surfactant mix at a certain temperature and carry out emulsifying, can obtain a kind of water in oil emulsus mixed solution;
The fill of e, medicament: the water in oil emulsus mixed solution that steps d is obtained is filled to by the liquid capsule filling machine that the blended rubber bar seals in the hollow liquid hard capsule, prepares liquid hard capsule of Anagex extract of the present invention.
The extracting solution of Maiwei-dihuang can be the extracting solution of water as the solvent preparation, also can be the extracting solution of ethanol as the solvent preparation, and preferred water is as the extracting solution of solvent preparation.
Edible oil, preferred Oleum Gossypii semen or Oleum Cocois or Oleum Arachidis hypogaeae semen or hydrogenated groundnut or Petiolus Trachycarpi oil or hydrogenated palm oil or soybean oil.
Surfactant, preferred single caprylin or glyceryl monolaurate or propylene glycol stearate or glyceryl monostearate or Arlacel-80 or Arlacel-60.
The method for concentration of Maiwei-dihuang decoction liquor is concentrating under reduced pressure or membrance concentration, and vacuum distillation temperature will hang down more than 30 degree than air-distillation usually, and membrance concentration is that the mode that makes aqueous solution pass through film filter filtering moisture concentrates, and this process is operated at normal temperatures.
Claims (6)
1. liquid hard capsule of Anagex extract and preparation method thereof, it is characterized in that: the content of this capsule fill is the mixing fraction that extracting solution, edible oil, the surfactant of Maiwei-dihuang formed, and its ratio is: extracting solution 10～80%, edible oil 10～80%, surfactant 1～40%.
2. liquid hard capsule of Anagex extract according to claim 1 and preparation method thereof is characterized in that may further comprise the steps:
The outfit of a, medical material: according to the recipe quantity ratio of Chinese traditional patent formulation preparation Maiwei-dihuang, take by weighing eight flavor Chinese crude drugs such as Radix Ophiopogonis, Fructus Schisandrae Chinensis, Radix Rehmanniae Preparata, Fructus Corni, Cortex Moutan, Rhizoma Dioscoreae, membrane inside the rush stalk Siberian cocklebur, Rhizoma Alismatis, its ratio is: 45 parts of Radix Ophiopogonis, 30 parts of Fructus Schisandrae Chinensis, 120 parts of Radix Rehmanniae Preparata, 60 parts of Fructus Corni (system), 45 parts of Cortex Moutans, 60 parts of Rhizoma Dioscoreaes, 45 parts of membrane inside the rush stalk Siberian cockleburs, 45 parts of Rhizoma Alismatis;
The extraction of b, medicament: the medical material that a set by step is equipped with adopts traditional water decocting method to extract, and will above eight flavor Chinese crude drugs adds water boil and extracts twice, filters and merges the decoction extracting solution twice;
Concentrating of c, medicament: the extracting solution of b set by step further is condensed into thick paste, obtains the concentrated extracting solution that active substance of the present invention is a Maiwei-dihuang;
The emulsifying of d, medicine: concentrated extracting solution that step c is obtained and the edible oil that contains surfactant mix at a certain temperature and carry out emulsifying, can obtain a kind of water in oil emulsus mixed solution;
The fill of e, medicament: the water in oil emulsus mixed solution that steps d is obtained is filled to by the liquid capsule filling machine that the blended rubber bar seals in the hollow liquid hard capsule, prepares liquid hard capsule of Anagex extract of the present invention.
3. liquid hard capsule of Anagex extract according to claim 2 and preparation method thereof, the extracting solution that it is characterized in that described Maiwei-dihuang, can be the extracting solution of water as the solvent preparation, also can be the extracting solution of ethanol as the solvent preparation, and preferred water is as the extracting solution of solvent preparation.
4. liquid hard capsule of Anagex extract according to claim 2 and preparation method thereof is characterized in that described edible oil, preferred Oleum Gossypii semen or Oleum Cocois or Oleum Arachidis hypogaeae semen or hydrogenated groundnut or Petiolus Trachycarpi oil or hydrogenated palm oil or soybean oil.
5. liquid hard capsule of Anagex extract according to claim 2 and preparation method thereof, it is characterized in that described surfactant, preferred single caprylin or glyceryl monolaurate or propylene glycol stearate or glyceryl monostearate or Arlacel-80 or Arlacel-60.
6. liquid hard capsule of Anagex extract according to claim 2 and preparation method thereof, the method for concentration that it is characterized in that described Maiwei-dihuang decoction liquor is concentrating under reduced pressure or membrance concentration, vacuum distillation temperature will hang down more than 30 degree than air-distillation usually, membrance concentration is that the mode that makes aqueous solution pass through film filter filtering moisture concentrates, and this process is operated at normal temperatures.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101476556A CN101700349B (en) | 2008-11-24 | 2008-11-24 | Liquid hard capsule of Anagex extract and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008101476556A CN101700349B (en) | 2008-11-24 | 2008-11-24 | Liquid hard capsule of Anagex extract and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101700349A true CN101700349A (en) | 2010-05-05 |
| CN101700349B CN101700349B (en) | 2012-05-23 |
Family
ID=42155293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008101476556A Expired - Fee Related CN101700349B (en) | 2008-11-24 | 2008-11-24 | Liquid hard capsule of Anagex extract and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101700349B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225152A (en) * | 2011-06-23 | 2011-10-26 | 贵州弘康药业有限公司 | Preparation method of Maiwei rehmannia oral preparation |
| CN105497499A (en) * | 2015-12-29 | 2016-04-20 | 贵州弘康药业有限公司 | Preparing method of Mai Wei Di Huang preparation |
| CN105560809A (en) * | 2015-12-29 | 2016-05-11 | 贵州弘康药业有限公司 | Production process of preparation containing radix ophiopogonis, processed schisandra chinensis and prepared rehmannia root |
| CN106047485A (en) * | 2016-07-04 | 2016-10-26 | 云南芯韵科技开发有限公司 | Aqueous capsule for cigarette and preparation method of aqueous capsule |
| CN106942787A (en) * | 2017-03-22 | 2017-07-14 | 云南芯韵科技开发有限公司 | A kind of cigarette microemulsion capsule and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1775264A (en) * | 2005-11-18 | 2006-05-24 | 北京阜康仁生物制药科技有限公司 | Maiwei-dihuang preparation and new preparing method |
-
2008
- 2008-11-24 CN CN2008101476556A patent/CN101700349B/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225152A (en) * | 2011-06-23 | 2011-10-26 | 贵州弘康药业有限公司 | Preparation method of Maiwei rehmannia oral preparation |
| CN102225152B (en) * | 2011-06-23 | 2012-07-25 | 贵州弘康药业有限公司 | Preparation method of Maiwei rehmannia oral preparation |
| CN105497499A (en) * | 2015-12-29 | 2016-04-20 | 贵州弘康药业有限公司 | Preparing method of Mai Wei Di Huang preparation |
| CN105560809A (en) * | 2015-12-29 | 2016-05-11 | 贵州弘康药业有限公司 | Production process of preparation containing radix ophiopogonis, processed schisandra chinensis and prepared rehmannia root |
| CN105497499B (en) * | 2015-12-29 | 2019-05-24 | 贵州弘康药业有限公司 | A kind of production method of Maiwei-dihuang preparation |
| CN106047485A (en) * | 2016-07-04 | 2016-10-26 | 云南芯韵科技开发有限公司 | Aqueous capsule for cigarette and preparation method of aqueous capsule |
| CN106942787A (en) * | 2017-03-22 | 2017-07-14 | 云南芯韵科技开发有限公司 | A kind of cigarette microemulsion capsule and preparation method thereof |
| CN106942787B (en) * | 2017-03-22 | 2020-05-01 | 云南芯韵科技开发有限公司 | Microemulsion capsule for cigarettes and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101700349B (en) | 2012-05-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101700349B (en) | Liquid hard capsule of Anagex extract and preparation method thereof | |
| CN103933116A (en) | Preparation process of herba leonuri paste | |
| CN100425227C (en) | Chinese medicine for relieving exterior syndrome, regulating stomach and eliminatnig dampness and its production | |
| CN104013802A (en) | Traditional Chinese medicine with anti-fatigue function and preparation method thereof | |
| CN101966244A (en) | Preparation method of sugar-free type anti-cold and antidotal granule | |
| CN101480484A (en) | Method for preparing miraculous powder preparation of ledebouriella | |
| CN100434093C (en) | 'Kidney-Benefiting' glucose injection and its preparing process | |
| CN102085327A (en) | Ginseng, tuckahoe and largehead atractylodes rhizome capsules | |
| CN102178733B (en) | Chinese medicinal preparation for treating diabetes and preparation method thereof | |
| CN101485689A (en) | Method for producing Chinese medicine pills | |
| CN102178754A (en) | Formula for nerve-calming effervescent tablets and preparation method thereof | |
| CN101084931A (en) | System and method for compounding boiled-free traditional Chinese medicine decoction pieces | |
| CN101690775A (en) | Medicament having qi-supplementing, blood-nourishing, kidney-boosting, yang-reinforcing and anti-cancer effects | |
| CN101301330A (en) | Codonopsis pilosula pollen capsules and preparation thereof | |
| CN1985944A (en) | Chinese medicine composition for treating cutaneous pruritus, rubella and other diseases | |
| CN101199669A (en) | Chinese medicine compound agent for treating female sperm quality lowclass | |
| CN101700273A (en) | Liquid hard capsule used for dredging channels and preparation method thereof | |
| CN103536820B (en) | Ganoderma is refreshed oneself compositions, medicinal tea and preparation method thereof and purposes | |
| CN103550629B (en) | Glossy ganoderma for tranquilization compositions, medicinal tea and preparation method thereof and purposes | |
| CN102987195B (en) | Method for preparing chufa and honey cough relieving health-care extract and health-care extract prepared by same | |
| CN101518584A (en) | Traditional Chinese medicine for curing urinary system infection and preparation method thereof | |
| CN104873454A (en) | TCM cakes containing single Chinese herbs and powders of TCM set prescription | |
| CN101264315A (en) | Chinese medicinal composition for treating dizziness | |
| CN104189833A (en) | Process for preparing xiaoyao pills | |
| CN100998776B (en) | Traditional Chinese medicine effervescent tablets for inducing sweat, cleaning damp and harmonizing middle-jiao, and its preparing method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Liquid hard capsule of Anagex extract and preparation method thereof Effective date of registration: 20150814 Granted publication date: 20120523 Pledgee: Zigong commercial bank Limited by Share Ltd Pledgor: Sichuan Xuyang Pharmaceutical Co., Ltd. Registration number: 2015990000684 |
|
| PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120523 Termination date: 20201124 |