CN101686825B - Adjusting acquisition protocols for dynamic medical imaging using dynamic models - Google Patents
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Abstract
The invention relates to automatically adjusting an acquisition protocol for dynamic medical imaging, such as dynamic CT, MR1 or PET imaging. The protocols are adjusted based on anatomic and dynamic models (10, 12, 14) which are individualized or fitted to each patient based on a scout scan (6, 8). The adjustment can compensate for changes in the patient due to patient motion (e.g. breathing or heartbeat) or flow of contrast or tracing agent during the sequence. This ensures that changes in the reconstructed images are indicative of pathological changes in the patient and not caused by patient motion or changes in scanning parameters or timing. The dynamic model can be a motion model (12) used to predict the motion of anatomic/physiologic features, typically organs, during scanning, or a haemodynamic model (14) used to predict flow of the contrast agent allowing for precise timing of the scanning sequence.
Description
Technical field
The present invention relates to dynamic medical imaging, the collection of a plurality of images in promptly during a period of time.Concrete, the present invention relates to adjust the acquisition protocols that is used for dynamic medical imaging.
Background technology
Medical imaging is to develop into diversified day by day in form a kind of technology-only enumerate several kinds in recent decades: nuclear magnetic resonance (MRI), computer tomography (CT), nuclear medicine (NM) and PET (PET).Although the conflict idea of medical imaging comprises " static state " IMAQ in order to the anatomic image of the organ/area of catching health; But the use of more and more more advanced imaging techniques allows to carry out dynamic studies, and it provides the temporal a series of images that can characterize physiology or Pathophysiology information.
Dynamically medical imaging can comprise that using imaging or contrast agent to come optionally to increase contrast regional in the image perhaps follows the absorption in the zone or flow promptly so-called Bolus Tracking.For example, can inject a kind of mixture for patient, it has the affinity on biophysics, molecule, gene or cell for certain organs, disease, state or physiological process.Select this contrast agent and can come to provide the characteristic of enhanced information to reflect the behavior of this mixture in health through changing image-forming condition (usually through changing contrast) for certain given imaging form so that have.Thereby contrast agent dynamically can move or change its distribution during the medical imaging, and the best setting of IMAQ also can change for continuous acquisition.
In addition, dynamically medical imaging can require patient in imaging device, to spend considerable time images acquired sequence.At this time durations, because the natural body kinematics such as breathing, heart beating etc., patient may move.This moves the accuracy that can destroy resulting image.
And, must carry out dynamic tracing research to keep watch on the for example variation of condition of illness, so that can confirm its characteristic or its reaction accurately to treatment.These follow up studys can spend several days or a few week, and need independent patient location.In the change meeting of patient location that repeatedly takes place between the follow up study and situation the quality of resulting image is caused adverse influence.
WO 04/080309 has described a kind of equipment and method, is suitable in CT scan, using guiding scanning (pilot scan) and static patient model to come recording parameters.For relating to dynamic imaging, prior art provides the technology of after collection, moving and revising of being used for, and for example sees WO 00/57361.This technology is not provided for improving the method for the gatherer process of dynamic imaging, and only is used to revise the image of being gathered.
US 2002/010551 discloses use contrast agent propagation model, and imaging is optimized to contrast enhancement mode.This contrast agent propagation model is an adaptivity, and receives real-time CT measurement data and produce predictor, and this predictor transports system by the self adaptation table top and is used for following the trail of this contrast agent.
Summary of the invention
Therefore, the problem of existence is, because the arrangement of time (timing) of the mistake relevant with organ movement or contrast agent flow causes the image of being rebuild not use, and the dynamic imaging sequence of therefore usually need reforming.
Therefore; Be used at dynamic medical imaging process or can be favourable in the improvement project that dynamically between the medical imaging motion is compensated, particularly a kind of mode more effectively and/or more reliably of the acquisition protocols that is used to adjust dynamic medical imaging can be favourable.
Most of current imaging protocols stem from the old mode of the single IMAQ on the slow low-resolution scanning device.These acquisition protocols only provide rough presetting, and must manually be adjusted into the setting and the motion of individual patient.According to technical staff's experience and technical ability, this situation can cause the setting of non-the best, thereby has produced the picture quality of non-the best, i.e. the use or the too high x-ray bombardment amount of the ineffective dose under the situation of research of must reforming.
Therefore, the present invention preferably manages individually or alleviates, relaxes or eliminate one or more above-mentioned defectives with the mode of combination in any.Concrete, can be regarded as providing acquisition protocols through adjustment so that realize more standardized, better metering, that recyclability is stronger and dynamic medical imaging that more simplify the object of the invention.
In first scheme of the present invention, a kind of method is provided, be used to adjust the acquisition protocols of the dynamic medical imaging of patient body volume.Said method comprises:
-reconstructed image of said patient's body volume is provided;
-anatomical model of said body volume is provided, and use said reconstructed image that said Model Matching (fit) is arrived said body volume;
-be provided for the preliminary acquisition protocols of the dynamic medical imaging of said body volume;
-motion model is provided for the one or more dissections in the said anatomical model and/or the motion of physiological feature;
-use said motion model to adjust the preliminary acquisition protocols that is provided, to compensate in motion to one or more characteristics described in the dynamic medical image acquisition process of said body volume.
In alternative plan, the invention provides a kind of computer program, be used for adjusting according to Claim 8 the preliminary acquisition protocols of the dynamic medical imaging that is used for the patient body volume.
In third party's case; The invention provides a kind of computer program; Be used to upgrade medical imaging apparatus, so that when the preliminary acquisition protocols of the dynamic medical imaging that is used for the patient body volume is adjusted, use motion model, said product comprises the module that is used for the install software application program; Said software application when carrying out by processor, be used for based on expression anatomical model one or more characteristics motion motion model data and following content is provided:
Use said motion model to adjust the preliminary acquisition protocols that is provided, so that compensation is in the motion of one or more characteristics described in the dynamic medical image acquisition process of said body volume.
Said computer program for example can be the renewal through network download and installation.
In cubic case, the invention provides a kind of medical imaging apparatus, it comprises the unit of the acquisition protocols that is used to adjust the dynamic imaging sequence, said device also comprises:
Be used for the body volume that will form images is carried out the instruction of location scanning (scout scan);
The preliminary acquisition protocols that is used for the dynamic medical imaging of said body volume;
Wherein, the data and the data of representing the motion model of the motion of one or more characteristics in the said anatomical model of the anatomical model of the said body volume of expression can be visited in said unit, and wherein, said unit comprises:
Be used for according to the module that said anatomical model is matched said body volume from the reconstructed image data of said location scanning;
Be used on the basis of said anatomical model and said motion model, adjust said preliminary acquisition protocols, with the motion of compensation in one or more characteristics described in the dynamic medical image acquisition process of said body volume.
Hereinafter, will a plurality of preferred and/or optional characteristics and key element be described to a plurality of embodiment of the present invention.Characteristic or key element to an embodiment or scheme description can combine or be applied to other embodiment or scheme under situation applicatory.
Said acquisition protocols can be that the one group of parameter, the device that are used to carry out the dynamic imaging sequence are set and operational order.To its typical case be provided to detailed description of the present invention.Acquisition protocols can be relevant with predetermined clinical practice, and can possibly select dynamic model to be suitable for this predetermined clinical practice in the dynamic model at several kinds.Thereby the adjustment of acquisition protocols means parameter, device setting and the operational order that changes or might increase agreement.Preferably, on the basis of the previous acquisition protocols that uses of patient, the previous image of gathering or extra non-image sensor information, carry out adjustment.Thereby to have caused the most wide in range aspect of the present invention be not with the record of clinical image or explain relevant, but only relevant with the preparation process of carrying out the dynamic imaging sequence.In addition, the step of acquisition protocols being adjusted does not comprise the reciprocal action with patient body.
Said anatomical model is used to predict the mean place and the shape of interested dissection and/or physiological feature.Dissection and/or physiological feature be organ normally, but also can refer to any further feature, for example, and particular joint, muscle, blood vessel, or refer to interested condition of illness in the intravital position of patient.
Said motion model is used to predict during scanning sequence dissects and/or the motion of physiological feature, promptly predicts position and shape at certain of some place preset time.Similarly, haemodynamic model is used to predict that contrast agent is in the arrangement expeced time of interested dissection and/or physiological feature.Term dynamic is used to indicate motion model and/or haemodynamic model.The time variation of using dynamic model to compensate in dissection and/or the physiological feature means the change parameter, installs and set or operational order, so that the realization IMAQ is with respect to the concordance of moving.Example for example can be IMAQ with respect to the patient's breath pattern or with the arrangement of time of the diffusion of contrast agent in patient's blood vessel.
Make a plurality of models or acquisition protocols individuation for example mean size through the details in model or the agreement being changed into patient, position, breathing, heart beating, contrast agent injection situation etc., model is applicable to or adjusts agreement to be suitable for given patient.
The reconstructed image of the body volume that provides at first can come from the location scanning that combines imaging sequence to carry out, and perhaps comes from the previous scanning of patient.The image of the body volume that this provides at first is used to make a plurality of model individuations, and need not to have with from the image of scanning sequence identical resolution or quality.
If the image of the body volume that provides at first is to come to survey CT or x-ray scanning, the X-ray dosage that just preferably uses the log resolution that reduces and/or be lower than preliminary acquisition protocols regulation is carried out this location scanning.Its advantage is to make patient to be exposed to lower X-ray dosage, and the disposal ability that has increased patient, because can gather lower quality/resolution image more quickly usually.Similarly consideration also is applicable to the PET imaging.
Similarly, survey MRI scanning if the image of the body volume that provides at first for example comes from, then lower resolution requirement can allow quicker and easier IMAQ.The MRI image that provides at first that comes from location scanning or alternate manner can have lower spatial resolution, and this is equivalent to only scan the spatial mid portion of k-.
As replacement scheme,, the said image that provides at first is provided through obtain the reconstructed image of previously stored patient body volume from previous location scanning or previous scanning sequence.For this reason, said device can comprise the storage vault of the reconstructed image of the precedence record that is used to preserve patient.When for example during many tracers are studied, under the situation of not reorientating patient, carrying out several scanning sequence continuously, this is favourable.At this, when starting a sequence each time, need not to carry out new location scanning and be used to make a plurality of model individuations.Alternatively, can use and come from the previous location scanning or the reconstructed image of scanning sequence.
Said preliminary acquisition protocols can be the standardized acquisition protocol that is used for relevant clinical application, and perhaps it can be the acquisition protocols of the patient's that fetches from storage vault previous adjustment.For this reason, said device can comprise and is used for preserving the storage vault of previous acquisition protocols and is used for fetching preliminary acquisition protocols and patient's the acquisition protocols through adjustment being stored in the module of this storage vault from this storage vault.Therefore, according to the feedback that comes from the analysis of previous image in the sequence, can be to further adjusting in the imaging sequence process or between each sequence through the acquisition protocols of adjustment.
Of the present invention second with third party's case relate to a kind of computer program.This computer program is adapted such that computer system can control medical imaging apparatus or this type of unit embodiment of the present invention, and said computer system comprises at least one computer, and said at least one computer has coupled data memory module.These schemes of the present invention concrete but advantage of nonexcludability is that the present invention can be realized that this computer program makes computer system can carry out the operation of first scheme of the present invention by a kind of computer program.Therefore, it is contemplated that,, some known medical imaging apparatus or this type of unit changed into according to the present invention move through on the computer system of the said optional recording equipment of control, computer program being installed.Can this computer program be provided on the computer-readable medium of any kind, for example, based on magnetic or optical medium, perhaps through computer based network, for example the Internet.
The present invention has overcome the limitation of conventional dynamic medical imaging acquisition protocols.Speaking of that the medicament accurately that absorbs for contrast agent in tumor or Target organ is followed the tracks of or during imaging, need compare much accurate arrangement of time with the tradition imaging by the quick acquisition rate of latest generation scanning device support.In addition,, need on the target visual field, carry out more accurate motion compensation, promptly carry out more accurate gating/triggering according to breathing or heart movement in order to make full use of this better resolution.Imaging performance is accurate more, and is just high more to the requirement of the patient-specific optimization of acquisition protocols.The object of the invention is the device or unit and the computer program that a kind of automatic process are provided and realize this process, and its agreement that is used to adjust dynamic image acquisition is set, to make full use of performance current and dynamic medical imaging scanning device in the future.In addition, hope that a plurality of embodiment of the present invention provides at least one or a plurality of following advantage:
-adaptive protocol for error tolerance is provided, it has greatly simplified operation of scanner
-make the fault-tolerant ability of acquisition protocols can guarantee to realize imaging according to the diagnostic instruction standard
-make the high speed dynamic imaging not too responsive for the variation in the arrangement of time of acquisition protocols
-avoid repeating imaging from the economy reason
-acceleration is also simplified the preparation to gathering, so that realize higher patient handling ability and better patient comfort
Comparable and the reproducible image of-acquisition
-improved for the comparability of following the trail of scanning, so that the metamorphosis of physical impairment is had better sensitivity, thereby can monitor growth or the tumor in time of tumor for example to the reaction of treatment etc.
-more effectively use X-ray dosage, promptly the better pictures quality can be provided or identical picture quality can be provided for less X-ray dosage for identical X-ray dosage.
Basic concepts of the present invention are automatically to adjust acquisition protocols according to dynamic model; So that can consider because the patient's that motion or flow of tracer cause variation; Thereby make variation in the reconstructed image can represent patient's pathological change, rather than because the variation in patient's motion or sweep parameter or the arrangement of time is caused.
Embodiment through with reference to following description sets forth, and these and other scheme of the present invention can become obvious.
Description of drawings
With reference to accompanying drawing, only explain the present invention as an example, wherein:
Fig. 1 is according to the method for the embodiment of the invention or the flow chart of computer program.
Fig. 2 shows the unit that is used for adjusting according to embodiments of the invention acquisition protocols in the medical imaging apparatus.
The specific embodiment
With reference to the flow chart of figure 1 a plurality of embodiment of the present invention is described; These embodiment relate to method, computer program and the software upgrading bag that is used for adjustment acquisition protocols on the basis of automatic and dynamic model, and the use of the embodiment relevant with device or unit.This description is summarized to method, but is applicable to each step of carrying out by each operation of software executing or when operative installations or the unit too.
Before the dynamic medical imaging of beginning, confirmed the clinical practice of resulting image usually, for example inspection, affirmation, supervision treatment of diseases process or evolution to tentative diagnosis.Clinical practice is the purpose of this imaging in other words conj.or perhaps, has confirmed to be carried out to picture and will to use which kind of formation method which part body volume and which organ or anatomic/physiologic features.Embodiments of the invention are applicable to various clinical practices and formation method.
In square frame 2, the initial acquisition protocol that is used for location scanning is provided.Formerly under scanned patient's the situation, fetch the acquisition protocols of the previous scanning of patient from storage vault 4.Scanning under patient's the situation for the first time, be used for tradition " standard " acquisition protocols of relevant clinical application and formation method.
The scan protocols that scan repository 4 is collected and related patient has lived through, preferred, also comprise corresponding view data.The core of this device or unitary individuation or " study " ability is variation, disease or the operator's (normally radiologist or technical staff) that are adapted to patient a imaging requirements.
Gather the location scanning of body volumes by dynamic medical imaging scanning device 6, scanning device 6 normally but be not limited to MRI, CT or pet scanner.Location scanning view data 8 to body volume is rebuild.
The anatomical model 10 of body volume is provided; And to the view data 8 of rebuilding by this location scanning it is carried out individuation and handle, this individuation is handled normally through for example by means of proportional zoom or the mathematic(al) manipulation such as nonlinear elastic deformation this model being mated or registration to the view data 8 of being rebuild.Purpose is the physical size of adjustment anatomical model with respect to patient, so that anatomical model can be used for predicting position and the size in the visual field of body volume organ and anatomic/physiologic features.This information is useful for for example optimizing dose distribution and reconstruction parameter.
Although the static parameter with respect to differences in patient makes the anatomical model individuation, the present invention also goes for the dynamic model to the time variation of one or more characteristics in body volume or anatomical model.According to clinical practice and formation method, this model can be motion model 12 and/or haemodynamic model 14.Motion model 12 is constructed to aim at anatomical model.It is used to predict by with respect to the motor pattern that patient's motion produced of previous scanner uni the expection organ movement of scan period.This information is for adjusting such as acquisition parameters such as the speed of table, gating and triggering levels so that be necessary for patient and/or organ movement's the influence minimum.In formation method, used haemodynamic model 14, so that follow the trail of the contrast agent that injects more accurately.It is constructed to aim at anatomical model and constitute, and is provided for predicting that contrast agent flows into the information of the situation of Target organ.This information is necessary for the arrangement of time more accurately of dynamic studies, thereby can utilize the better resolution of advanced scanner and the picking rate of Geng Gao to come more accurately aiming and follow the trail of contrast agent.
In square frame 16, use and adjust acquisition protocols from the information of anatomical model and dynamic model.Again, if before scanned patient, just will be from the acquisition protocols of storage vault 4 basis as this adjustment, if before not scanned patient, the standard acquisition agreement that just will be used for relevant clinical application and formation method is used as the basis of this adjustment.
As by another optional step shown in the connector 19, estimate this final reconstructed image data collection 18 by the operator, and then adjust the next time IMAQ of acquisition protocols if necessary for use in current dynamic studies.
In addition, shown in connector 20, final reconstructed image data collection 18 with adding in the storage vault 4 through the agreement of confirming, is used for this patient's the better preliminary sweep agreement of inspection next time with definition.This characteristic helps said device or unitary individuation or " study " ability.
When being implemented as computer program, more than the square frame described with reference to figure 1 can be implemented as operation with step by one or more software applications execution.Be used to upgrade medical imaging apparatus and only comprise the software application that is used to carry out the operation that this device can not carry out with the computer program of using this method.Therefore, the scope of this update software can depend on concrete model and any previous installed software renewal of medical imaging apparatus.
Below, with describe according to the exemplary parameter in the acquisition protocols of the present invention and how the adjustment through agreement change these parameters.
Below will provide the example of typical acquisition protocol parameters, how in current scanning process, to confirm these parameters usually and how adjust these parameters in an embodiment of the present invention.
A parameter can be the total amount of the contrast agent of use during medicament is followed the trail of.It is normally confirmed by the patient body weight tables of data.As an example of adjustment, the distance between injection point and target area can be confirmed that the diffusion of medicament can be predicted by haemodynamic model by anatomical model.This can realize the dosage that contrast agent is more accurate, thereby better picture quality and less contrast agent (it is expensive and deleterious to patient) are provided.
Another parameter can be the arrangement of time that scanning sequence begins, for example the delay after contrast-medium injection or synchronous with patient's motion.This is normally based on operator's experience.As an example of adjustment, can use haemodynamic model to confirm sweep start arrangement of time, and can use motion model automatically to confirm arrangement of time with respect to breathing/heart beating based on the motion sensor input with respect to contrast-medium injection.
Therefore, from a viewpoint,, expand by anatomical model and dynamic model in order to the operator's experience of confirming acquisition protocol parameters and the principle that the operator need follow, thereby can realize Automatic Optimal acquisition protocols according to some embodiments of the present invention.
Below, provided the anatomical model of the present invention's use and some examples of dynamic model.It should be noted that these are existing examples of these models, and be active research field very.Therefore, can develop and in the future carry out similar functions but have multi-form model, its use is also thought to fall in the scope of the present invention.
Motion model 12 is used to predict patient's the organ or the motion of other anatomic/physiologic features, by the motion that causes below for example: respiratory movement; The variation of heart beating, wriggling, patient location; The packing ratio of bladder, harmonization of the stomach intestinal etc. etc.Motion model not only with the imaging sequence process in motion relevant (second-hour), but also relevant with the motion between follow-up imaging sequence (hour-day).Through comprising time parameter, can motion model be combined with above-mentioned different anatomic model.For surface and volume-based model, each surface or volume element can be associated with the motion vector that moves of describing this element-specific.Can use general motion vector field, it has described the standard movement of typical patient's anatomic entities, perhaps can carry out the individuation adjustment so that use the motion vector of deriving to given patient to motion model.For the parameter anatomical model, motion can combine extra parametric variable, i.e. the sensor signal of time or monitoring breath state or heart beating.These parameter models can be the sports grounds of being represented by mathematic(al) manipulation, for example, are represented as one of various ways of batten conversion.
In order motion model to be carried out the individuation adjustment, can keep watch on patient's motion, normally through using one of following situation:
Pick off: can breathe by estimating, estimate heart beating by ECG around the belt of chest, these data can the input motion model in so that it is carried out the individuation adjustment.
Scan self: in a period of time, carry out dynamic imaging scanning usually; During feeling suffocated or with respect to carrying out dynamic imaging scanning in the arrangement of time of breathing or ECG,, and its input model is used for adjustment subsequently so that can confirm motor pattern from scanning self.
By above conspicuous, for example,,, can make anatomical model 10 and motion model 12 be arranged in same computer representation perhaps through time or sensor parameters are included in the parameter model through with each surface of motion vector note or volume element.
The function of haemodynamic model 14 is where when the prediction contrast agent arrive in the blood system, so that IMAQ or scanning sequence can begin automatically, perhaps can confirm the intravenous arrangement of time with respect to contrast agent or other probe materials.Contrast agent or the tracer typical expected characteristic in zones of different is the comprising of radioisotope of change and nuclear medicine/PET of parameter characteristic of increase, the MRI of the X-ray decay of CT/X light.
Haemodynamic model 14 can be the anatomical model of time graph, equality or the label time of interested vascular system; When it has described contrast agent through a given vessel cross-sections, and what dosage to pass through this given vessel cross-sections as the function of time with.In one embodiment, the operator should import or select injection point and target area, thereby can predict that through the anatomical model 10 of individuation adjustment haemodynamic model 14 is carried out individuation adjusts required correlation distance.In one embodiment, come the time of implementation to arrange through for example keeping watch on large artery trunks, and when in large artery trunks, detecting contrast agent, labelling is set, and use through the haemodynamic model of individuation adjustment and predict the arrival target area.Haemodynamic model is a current very active research topic, and the following model of carrying out similar functions is also thought and fallen in the scope of the present invention.
Refer again to Fig. 1, can form whole execution or device or the unitary operational overview of method or software of the parameter of acquisition protocols and be being used on the basis of model 10,12 and 14 adjustment:
-with anatomical model 10 and size and shape alignment from the patient of location scanning view data 8;
-for example confirm organ movement's situation through pick off or dynamic scan, and be associated with predicted motion with motion model 10;
-keep watch on contrast-medium injection or mobile, use haemodynamic model 14 to confirm the arrangement of time of imaging sequence through Target organ according to contrast agent.
Below, to the bright details of the present invention of concrete clinical practice as an exampleBSEMGVR takeN-PSVSEMOBJ of contrast enhanced liver imaging.Liver is to change in size and shape, and its position receives respirometric influence, and the optimum contrast of tremulous pulse, portal vein and late stage depends on that the circulation of liver is connected.Therefore, the optimum contrast in each stage depends on that the amount, injection rate, inject time of contrast agent are arranged and different phase is carried out to the delayed sweep of picture.Current, need experienced operators under size, body weight and the body constitution and the interferential situation of any circulation of considering patient, confirm the optimal acquisition setting heuristicly.
Use hereto, with reference to figure 1, can with according to the method for the invention or the embodiment of software be embodied as as follows:
Storage vault 1 provides patient's arbitrarily previous scan protocols, and it is produced by previous inspection, and has comprised any previous adjustment to patient's individual state.
The motion model 12 of three-dimensional vector format of field is constructed to aim at anatomical model 10, and its expection displacement with liver was associated with the breathing cycle.This information provides parameter for the motion-compensated collection and the reconstruction technique of each stage diagram picture.
Haemodynamic model 14 is constructed to aim at anatomical model 10, and it is associated amount and the injection rate of the contrast agent of injection with the desired contrast in liver of process in time.The amount of the contrast agent that this has confirmed to inject, and defined and arrange and speed best inject time, and to the corresponding arrangement of time of the collection of different phase image.
After each stage, adjust the agreement of the collection that is used for the next stage according to the result of the situation of contrast research and previous stage.The Hounsfield value of prediction is used to readjust model and relevant acquisition parameter with any deviation of actual observed value.
The agreement that will be used for next phase acquisition is shown to that technical staff/radiologist approves or the interactivity corrigendum.
Storage vault 1 is expanded by the agreement of final execution, and circulation restarts, and all passes through collection up to whole required stages.
Can form images to any Dynamic CT and use the present invention, wherein, its advantage is: operation and the better support to diagnosing and treating simplified are provided.In addition, said device or unit can be used to adjust the acquisition protocols that is used for other the dynamic medical imaging technology such as MRI or PET scanning.Other possible application examples is as being quality and the comparability that improves the dynamic MR imaging; It comprises the management and the tracking of the visible contrast agent of MR such as perfusion or angiography research and PET research; So that characterize tumor physiology, thereby improved diagnosis and therapeutic response evaluation.
As previously mentioned, can realize the present invention, comprise hardware, software, the software kit that is used to upgrade, firmware or its combination in any with any suitable form.The present invention or some characteristic of the present invention can be implemented as the computer software that operates on one or more data processors and/or the digital signal processor.Can be physically, on the function or realize the element and the assembly of the embodiment of the invention in logic in any suitable manner.In fact, can be in individual unit, realize said function in a plurality of unit or as the part of other functional unit.Equally, the present invention can realize in individual unit, perhaps physically with on the function is being distributed in different units and the processor.
Fig. 2 shows the data processor 22 such as computer, and it has embodied the embodiment relevant with device or unit, and for example, it is used to carry out the computer program according to other embodiments of the invention.Should understand illustrating of Fig. 2 according to the flow chart of describing to Fig. 1.
In Fig. 2, data processor 22 receives the acquisition protocols that will adjust its parameter.If there is not previous adjusted agreement in patient hereto, then this agreement just can be a standard agreement 24, and perhaps this agreement can be the previous adjusted agreement 25 from the previous inspection of patient of storage in storage vault 4.After receiving agreement (24 or 26); Data processor 22 executive softwares or execution are from other software or operator's instruction; So that as it is described to be directed against Fig. 1, on the basis of anatomical model and dynamic model (10,12,14), carry out adjustment to the agreement that receives.Data processor 22 can through as directed with data performances be kept in the internal storage or through access on the memorizer externally they, come the various models of access.In addition, data processor 22 receives view data 8 from location scanning, is used for the individuation adjustment of model 10,12 and 14.
The acquisition protocols 28 of data processor 22 outputs through adjusting, the patient's who is used to be checked dynamic imaging, and can also be used at this acquisition protocols 28 through adjustment of storage vault 4 storages, as shown in arrow 20.
Data processor 22 can be configured for carrying out whole device of the present invention or unit or its part.Therefore, data processor 22 can be the part of the scanning device such as CT, MRI or pet scanner, thereby allows scanning device basic thought according to the present invention to operate.
Although combined specific embodiment to describe the present invention, it is not to be intended to be limited to the particular form that this paper proposes.On the contrary, scope of the present invention is only limited appended claims.In claims, word " comprises " existence of not getting rid of other element or step.In addition,, can advantageously make up them, be included in the different claim and do not mean that these combination of features are infeasible and/or do not have advantage although each characteristic can be included in the different claim.In addition, singular references is not got rid of plural form.Therefore, do not get rid of a plurality of to referring to of " (a, an) ", " first ", " second " etc.And the reference marker in claims should not be construed as the restriction to scope.
Claims (10)
1. one kind is used for method that the acquisition protocols of the dynamic medical imaging of patient body volume is adjusted, and said method comprises:
-reconstructed image (8) of said patient's body volume is provided;
-anatomical model (10) of said body volume is provided, and use said reconstructed image that said Model Matching is arrived said body volume;
-be provided for the preliminary acquisition protocols (24,26) of the dynamic medical imaging of said body volume;
-motion model (12) is provided for the one or more dissections in the said anatomical model and/or the motion of physiological feature;
-use said motion model to adjust the preliminary acquisition protocols that is provided, to compensate in said motion to one or more characteristics described in the dynamic medical image acquisition process of said body volume.
2. the method for claim 1, wherein pass through the location scanning (6) and the reconstructed image (8) of the said patient's of collection body volume, the said reconstructed image of said body volume is provided.
3. the method for claim 1, wherein reconstructed image of the body volume through fetching previously stored said patient provides the said reconstructed image of said body volume.
4. like aforementioned any described method of claim, also comprise: will present to the operator so that approve and/or further adjustment through the acquisition protocols (28) of adjustment.
5. the method for claim 1 also comprises: during the dynamic imaging sequence, according to from the feedback to the analysis of previous image in the said sequence, the acquisition protocols of warp adjustment is carried out further adjustment.
6. the method for claim 1 also comprises: will be stored in the storage vault (4) from the image (18) of the dynamic imaging sequence of being gathered, so that fetch the coupling that is used for carrying out said anatomical model as the reconstructed image that initially provides after a while.
7. the method for claim 1 also comprises:
In conjunction with said motion model, haemodynamic model (14) is provided, be used for predicting that contrast agent is in the said one or more dissections of said anatomical model and/or the arrangement of time at physiological feature place;
Use said motion model and said haemodynamic model to adjust the preliminary acquisition protocols that is provided, change in time one or more characteristics described in the dynamic medical image acquisition process of said body volume with compensation.
8. one kind is used for device that the acquisition protocols of the dynamic medical imaging of patient body volume is adjusted, comprising:
-be used to provide the module of reconstructed image (8) of said patient's body volume;
-be used to provide the anatomical model (10) of said body volume, and use said reconstructed image with the module of said Model Matching to said body volume;
-be used to be provided for the module of preliminary acquisition protocols (24,26) of the dynamic medical imaging of said body volume;
-the motion that is used to one or more dissections and/or physiological feature in the said anatomical model provides the module of motion model (12);
-use said motion model to adjust the preliminary acquisition protocols that is provided, with compensation in module to the said motion of one or more characteristics described in the dynamic medical image acquisition process of said body volume.
9. medical imaging apparatus comprises the unit of the acquisition protocols that is used to adjust the dynamic imaging sequence
(22), said device also comprises:
Be used for the body volume that will form images is carried out the instruction of location scanning (6);
The preliminary acquisition protocols (22,24) that is used for the dynamic medical imaging of said body volume;
Wherein, said cell access representes that data and the expression of the anatomical model (10) of said body volume are used for the data of motion model (12) of motion of one or more characteristics of said anatomical model, and wherein, said unit comprises:
Be used for according to the module that said anatomical model is matched said body volume from the reconstructed image data (8) of said location scanning;
Be used on the basis of said anatomical model and said motion model, adjust said preliminary acquisition protocols, with the module of compensation in the motion of one or more characteristics described in the dynamic medical image acquisition process of said body volume.
10. device as claimed in claim 9 also comprises:
Storage vault (4) is used to preserve acquisition protocols; And
Be used for fetching said preliminary acquisition protocols and being used for storing patient's acquisition protocols (28) module of said storage vault into through adjustment from said storage vault.
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| US8705819B2 (en) | 2014-04-22 |
| US20100183206A1 (en) | 2010-07-22 |
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| EP2160135B1 (en) | 2012-08-15 |
| WO2008155738A2 (en) | 2008-12-24 |
| CN101686825A (en) | 2010-03-31 |
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