CN101617661B - High-efficiency compound preservative for daily chemical products - Google Patents
High-efficiency compound preservative for daily chemical products Download PDFInfo
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- CN101617661B CN101617661B CN2008100291853A CN200810029185A CN101617661B CN 101617661 B CN101617661 B CN 101617661B CN 2008100291853 A CN2008100291853 A CN 2008100291853A CN 200810029185 A CN200810029185 A CN 200810029185A CN 101617661 B CN101617661 B CN 101617661B
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Abstract
The invention relates to a high-efficiency compound preservative for daily chemical products, which is characterized by consisting of the following components according to the mass fraction of 100 percent: 45 to 55 percent of 1,3-dihydroxymethyl-5,5-dimethylhydantoin, 5 to 10 percent of the 2-bromo-2-nitro-1,3-propanediol, 5 to 10 percent of 2,4,4'-trichloro-2'-hydroxy diphenyl ether and the balance of a solubilizer of polyethenoxy ether or polyoxypropylene ether. The compound preservative has less usage, strong bactericidal power and strong lasting effect, the sterilizing rate can reach 99.5 percent in 6 hours when the use concentration is 0.05 percent of the mass friction, the inhibiting and killing effect on living beings is obviously stronger compared with that of the independent use of each bactericide, and the sterilizing rate after 24 hours can reach 99.99 percent and can be still maintained in 240 hours, thus the high-efficiency compound preservative can be used as the preservative for the daily chemical products of detergents, shower gel, gel, skin care cream and the like.
Description
Technical field
The present invention relates to a kind of preservative, relate in particular to a kind of high-efficiency compound preservative that suppresses the daily chemical products microorganism that is used for killing.
Background technology
The use of daily chemical products has a long history, and the human early stage daily chemical products great majority that use all are natural mineral matters, itself antibacterial ability are just arranged, and do not have anticorrosion problem.But raising along with expanding economy and living standards of the people; People constantly increase the demand of daily chemical products; In order to satisfy the many-sided demand of people; Increasing biologically active raw material is applied in the daily chemical products, and some components in these raw materials such as lipid, alcohol, water-soluble high polymer, protein etc. just in time offer the growth of microorganism breeding with the rich nutrient substances and the energy.And because the daily chemical products production technology is comparatively simple; Generally must be as food and pharmaceutical production, and daily chemical products is a kind of commodity that are repeatedly used through sterilization or degerming technology, receive microbial contamination more easily and putrid and deteriorated; And lose commodity value; And rotten daily chemical products can produce phenomenons such as peculiar smell, layering, variable color and mildew, and the toxin that produces in the growth of microorganism reproductive process simultaneously can cause inflammation such as the user is allergic, is detrimental to health.And the desirable efficient sterilizing protective system that is applicable to daily chemical products should have following characteristic: 1. efficient, wide spectrum have antibacterial and double action sterilization; 2. compatibility is good, has fine solubility and dispersiveness, can not influence key property, color and luster and the smell of product; 3. the bigger pH value scope of application arranged, the activity that can in manufacture process and under the storage temperature condition, maintain a long-term stability; 4. addition is little, and is rapid-action, and sterilizing power is strong; 5. safe, non-stimulated to the human non-toxic evil, can not produce allergy, phototoxicity and variability; 6. easy to use, cheap; 7. be environment-friendly type " green product " etc.
From eighties of last century seventies; A lot of aseptic applications are just arranged in daily chemical products, wherein using maximum is chemical preservative, though the kind of chemical preservative is a lot; But great majority all have certain toxicity to human body, thereby also receive certain restriction on using.China's working concentration and scope to 66 kinds of daily chemical products preservatives in " daily chemical products sanitary standard " done restriction; The U.S. gets permission or the preservative of temporarily getting permission in daily chemical products, to use has 120 kinds; There is kind more than 70 in the European Economic Community, but commonly used have only one, 20 kind.The most frequently used daily chemical products preservative has parabens, imidazolidinyl urea, two imidazolidinyl urea, card pine, 1 both at home and abroad at present; 3-dihydroxymethyl-5; 5-dimethyl hydantoin (DMDM), 2-bromo-2-nitro-1.3-propane diols (cloth sieve bohr), 2; 4,4 '-three chloro-2 '-dihydroxy diphenyl ethers (triclosan DP300), dehydroacetic acid, sodium hydroxy methyl glycinate, iodo propinyl carbamate (IPBC), Phenoxyethanol, parachlorometaxylenol and formaldehyde etc.These preservatives in use ubiquity some problems: parabens preservative poorly water-soluble, have only the antifungi ability, and the antibacterium ability is lower, and is especially relatively poor to Gram-positive bacillus and lactic acid bacteria effect; Isothiazolinone (CMI/MI) preservative stability is relatively poor, and excitant is strong, can cause the irritated inflammation of skin irritatin; It is poor that imidazolidinyl urea preservative antifungi and yeast are renderd a service, and anticorrosion cost is high; Hydantoins preservative fungal resistance is relatively poor; IPBC preservative excitant is big, fungistatic effect than parabens more a little less than; Phenoxyethanol preservative antibacterial efficacy is low, and anticorrosion cost is high; Formaldehyde toxicity is big, and strong carcinogenesis is arranged, and therefore the use at industrial products is restricted as preservative, therefore also can predict its use in daily chemical products and also will be restricted.Control effect preferably owing to use single preservative all can't reach; Some enterprise in daily chemical products, adds multiple preservative or Compositional antiseptic agent strengthens antiseptic effect, adopts that multiple preservative is composite can be cooperated really effectively, learns from other's strong points to offset one's weaknesses; Reach and widen antimicrobial spectrum; Improve drug effect and safety, anti-secondary pollution, prevention pesticide resistance etc.But homemade Compositional antiseptic agent is of less types; Antiseptic effect is also barely satisfactory; Present antiseptic effect Compositional antiseptic agent preferably is imported product; Like the Germall series of ISP company, the Oxaban series of Angus chemical company, the Glydant plus liquid of Algroup Lonza company etc., but the cost of imported product is too high.In the face of the industrial chemicals that grows to even greater heights, it is low cost effective corrosion-resistant preservative again that daily use chemicals enterprise all hopes to obtain.
Summary of the invention
The objective of the invention is to develop a kind of promptly efficient cheap again daily chemical products compound preservative.
We pass through 2-bromo-2-nitro-1, ammediol, 2,4; 4 '-three chloro-2 '-dihydroxy diphenyl ether, 1,3-dihydroxymethyl-5 is after the 5-dimethyl hydantoin mixes in proportion; Add the dissolving of solubilizer APEO or polyethenoxy ether, the compound disinfectant that obtains demonstrates unique synergy, can suppress the breeding of microorganism in the daily chemical products effectively; And killing microorganisms, and with low cost, thus realized the object of the invention.
The compound preservative of daily chemical products of the present invention, it is characterized in that by mass fraction 100% by 45%～55% 1,3-dihydroxymethyl-5; The 5-dimethyl hydantoin; 5%～10% 2-bromo-2-nitro-1, ammediol, 5%～10% 2; The solubilizer APEO of 4,4 '-three chloro-2 '-dihydroxy diphenyl ethers and surplus or polyethenoxy ether are formed.
The preparation method of the compound preservative of daily chemical products of the present invention is with 2-bromo-2-nitro-1, ammediol; 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ethers and 3-dihydroxymethyl-5; After the 5-dimethyl hydantoin mixes in proportion, add the solubilizer dissolving, dispersed with stirring evenly obtains.
Though 1,3-dihydroxymethyl-5, the fungal resistance of 5-dimethyl hydantoin (DMDM hydantoins) is poor, and the ability that suppresses bacterium is stronger, and low to the excitant of human body skin, even can be used for articles for babies; 2-bromo-2-nitro-1; Ammediol (cloth sieve bohr) all has stronger inhibitory action to bacterium, mould and saccharomycete; And to compare mould and saccharomycete is strong to the inhibition ability of bacterium, Gram-negative bacteria (like Pseudomonas aeruginosa) is shown good inhibition effect, not receive the influence of compositions such as yin, yang ionic surface active agent or protein; Little to the human body excitant, environmentally safe; 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ethers (triclosan DP300) all have kill activity to Gram-negative bacteria and positive bacteria, have the advantages of good skin compatibility simultaneously, and with daily chemical products raw material excellent compatibility, can be decomposed by environment.
The present invention carries out above-mentioned three kinds of bactericide composite; Not only effectively widened the bactericidal spectrum; And because of act synergistically its to microorganism press down to kill effect than using strong tens of times to hundred times separately, when working concentration is mass fraction 0.05%, just can in 6 hours, make sterilizing rate reach 99.5%, working concentration is than using each bactericide minimizing more than 1/4 separately; Biology press down killed effect obviously than each bactericide of use is stronger separately; Sterilizing rate after 24 hours can reach 99.99%, and still can keep 99.99% to 240 hours sterilizing rate, just can make the bactericide sterilizing rate reach 99.99% and use each bactericide will arrive 72 hours at least separately.Therefore compound preservative of the present invention not only has good synergistic function, and usage amount is few, sterilizing power is strong, also has stronger lasting effect, can be used as the preservative of daily chemical products such as liquid detergent, shower cream, gel water, skin care face cream.
Embodiment
Following examples are to further specify of the present invention, are not limitations of the present invention.
Embodiment 1:
With cloth sieve bohr 0.5kg, after triclosan DP3001kg and DMDM hydantoins 4.5kg fully mix,, add solubilizer APEO 4kg dissolving; After evenly stirring, obtain compound preservative, contain mass fraction in the compound preservative and be 45% 1,3-dihydroxymethyl-5; 5-dimethyl hydantoin, mass fraction are 5% 2-bromo-2-nitro-1, ammediol, mass fraction be 10% 2; 4,4 '-three chloro-2 '-dihydroxy diphenyl ethers, all the other mass fractions 40% are solubilizer.
Embodiment 2:
With cloth sieve bohr 1kg, after new DP300 0.5kg of Yu Gu and DMDM hydantoins 5.0kg fully mix, add solubilizer polyethenoxy ether 3.5kg dissolving, after evenly stirring; Obtain compound preservative, contain mass fraction in the compound preservative and be 50% 1,3-dihydroxymethyl-5,5-dimethyl hydantoin; Mass fraction is 10% 2-bromo-2-nitro-1, ammediol, mass fraction be 5% 2; 4,4 '-three chloro-2 '-dihydroxy diphenyl ethers, all the other mass fractions 35% are solubilizer.
Embodiment 3:
With cloth sieve bohr 0.9kg, after triclosan DP300 0.9kg and DMDM hydantoins 5.5kg fully mix, add solubilizer APEO 2.7kg dissolving, after evenly stirring; Obtain compound preservative, contain mass fraction in the compound preservative and be 55% 1,3-dihydroxymethyl-5,5-dimethyl hydantoin; Mass fraction is 9% 2-bromo-2-nitro-1, ammediol, mass fraction be 9% 2; 4,4 '-three chloro-2 '-dihydroxy diphenyl ethers, all the other mass fractions 27% are solubilizer.
Embodiment 4:
With cloth sieve bohr 1.0kg, after triclosan DP300 1.0kg and DMDM hydantoins 5.5kg fully mix, add solubilizer polyethenoxy ether 2.5kg dissolving, after evenly stirring; Obtain compound preservative, contain mass fraction in the compound preservative and be 55% 1,3-dihydroxymethyl-5,5-dimethyl hydantoin; Mass fraction is 10% 2-bromo-2-nitro-1, ammediol, mass fraction be 10% 2; 4,4 '-three chloro-2 '-dihydroxy diphenyl ethers, all the other mass fractions 25% are solubilizer.
Embodiment 5:
The compound preservative that embodiment 1 is obtained is used for each microorganism fungus kind, measures its minimal inhibitory concentration, and with independent use DMDM hydantoin, cloth sieve bohr and triclosan DP300 contrast, and the result sees table 1.
Embodiment 6:
The compound preservative that embodiment 2 is obtained is diluted to different concentration (mass fraction); Act on mixed cell (forming) and mix mould (forming) by candida albicans, aspergillus niger, penicillium funiculosum, Trichoderma viride, chaetomium globosum by Escherichia coli, staphylococcus aureus, pseudomonas aeruginosa, Bacillus subtillis; Be respectively 30 minutes and 6 hours action time; Test its sterilizing rate, the result sees table 2.
Table 1 compound preservative of the present invention and the minimum inhibitory concentration contrast of using each bactericide to microorganism fungus kind separately
Table 2: compound preservative of the present invention is at the bactericidal effect of variable concentrations and action time
Embodiment 7:
Adopt the minimum working concentration of each bactericide; The DMDM hydantoins that in clear water, respectively adds mass fraction 0.2%; Cloth sieve bohr of mass fraction 0.1%; The compound preservative that the triclosan DP300 of mass fraction 0.1% and the embodiment 3 of mass fraction 0.05% obtain inserts the microorganism of equivalent amount respectively, observes the bactericidal effect of system.The result sees table 3, and wherein 0 o'clock bacterium number is the initial bacterium number after referring to an access microorganism, and "＜10 " represent that this does not detect bacterium.
Table 3 compound preservative of the present invention and the bactericidal effect contrast of using each bactericide to microorganism fungus kind separately
Embodiment 8:
In 1 ton of liquid detergent, add the compound preservative 0.75L (actual usage amount is 0.05%) that embodiment 1 obtains, sampling and testing bactericidal effect after the can.The result sees table 4.
In 2 tons of shower creams, add the compound preservative 1L (actual usage amount is 0.05%) that embodiment 2 obtains, sampling and testing bactericidal effect after the can.The result sees table 4.
In 1.2 tons in gel water, add the compound preservative 0.96L (actual usage amount is 0.08%) that embodiment 3 obtains, the test of microorganism preservation challenge is carried out in sampling after the can.The result sees table 4.
In 1 ton of skin care face cream, add the compound preservative 1.0L (actual usage amount is 0.1%) that embodiment 4 obtains, sampling and testing bactericidal effect after the can.The result sees table 4.
More than each experiment all by according to American Pharmacopeia USP23 < 51>microorganism preservative efficacy test and TTB (Determination ofmicrobiological product-stability by the challenge test) execution.Connect the bacterium amount and be the 1.0mL/100g sample, bacterium liquid concentration is 6.3 * 10
8Cfu/mL, mould liquid concentration is 8.8 * 10
6Cfu/mL.
Table 4: compound preservative of the present invention is to the sterilization and anticorrosion effect of various daily chemical products
Claims (1)
1. compound preservative that is used for daily chemical products, it is characterized in that by mass fraction 100% by 45%～55% 1,3-dihydroxymethyl-5; The 5-dimethyl hydantoin; 5%～10% 2-bromo-2-nitro-1, ammediol, 5%～10% 2; The solubilizer APEO of 4,4 '-three chloro-2 '-dihydroxy diphenyl ethers and surplus or polyethenoxy ether are formed.
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| CN2008100291853A CN101617661B (en) | 2008-07-03 | 2008-07-03 | High-efficiency compound preservative for daily chemical products |
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| CN2008100291853A CN101617661B (en) | 2008-07-03 | 2008-07-03 | High-efficiency compound preservative for daily chemical products |
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| CN101617661A CN101617661A (en) | 2010-01-06 |
| CN101617661B true CN101617661B (en) | 2012-11-21 |
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| CN111544310A (en) * | 2020-05-28 | 2020-08-18 | 安徽省天助纺织科技集团股份有限公司 | Non-irritant antibacterial disinfectant wet tissue and preparation method thereof |
| CN113549358A (en) * | 2021-07-28 | 2021-10-26 | 陕西省石油化工研究设计院 | Composite preservative for paint and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997024031A1 (en) * | 1995-12-29 | 1997-07-10 | Buckman Laboratories International, Inc. | Synergistic antimicrobial compositions containing 1-hydroxymethylpyrazole and a preservative |
| WO1999065316A1 (en) * | 1998-06-19 | 1999-12-23 | Lonza Inc. | Stabilized mixtures of an iodopropargyl compound and a formaldehyde donor |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997024031A1 (en) * | 1995-12-29 | 1997-07-10 | Buckman Laboratories International, Inc. | Synergistic antimicrobial compositions containing 1-hydroxymethylpyrazole and a preservative |
| WO1999065316A1 (en) * | 1998-06-19 | 1999-12-23 | Lonza Inc. | Stabilized mixtures of an iodopropargyl compound and a formaldehyde donor |
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