CN101554190B - Edible oil containing two types of essential fatty acid - Google Patents
Edible oil containing two types of essential fatty acid Download PDFInfo
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- CN101554190B CN101554190B CN200810103652.2A CN200810103652A CN101554190B CN 101554190 B CN101554190 B CN 101554190B CN 200810103652 A CN200810103652 A CN 200810103652A CN 101554190 B CN101554190 B CN 101554190B
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Abstract
The invention relates to an edible oil containing two types of essential fatty acid, which is a mixture prepared by Alpha-linolenic acid or metabolite thereof and linolenic acid or metabolite thereof according to the proportion of 1:1 to 10. The invention emphasizes that Omega-6 multi-carbon unsaturated fatty acid and Omega-3 multi-carbon unsaturated fatty acid are added simultaneously according to proportion. The invention also relates to compatibility of essential fatty acid and relevant universal Omega-3 edible oil, medicine, functional food, nutrient food and fortified food so as to ensuremaximum optimization of biological effect groups for metabolism in the body of two types of essential fatty acid, namely linolenic acid and Alpha-linolenic acid, provides nutrition for organisms andis used for treating and preventing cardiovascular and cerebrovascular diseases.
Description
Technical field
The present invention relates to a kind of edible oil, relate to a kind of edible oil containing ω-3 and ω-6 two kinds of essential fatty acids particularly.
Background technology
Blending edible oil concept is rooted in the hearts of the people, and guiding uses ready-mixed oil to be correct, but how to be in harmonious proportion, be then the problem that people extremely pay close attention to.In fact consume oil is exactly the absorption of human body to fat, closely related with fatty acid metabolism.
Lipid in human body, is divided into two parts, that is: fat and lipoid.Fat, also known as triglycerides (edible oil), is be combined into by a part glycerine and three molecules of fatty acids, and the fatty acid species of composition natural fat is a lot, also different to the effect of human body.Fat can be divided into energy fat and structural fatty generally.Energy fat is also known as saturated fat, primarily of saturated fatty acid composition, be stored between the subcutaneous connective tissue of people, omentum majus, mesenterium, flesh around connective tissue and some internal organs, these fat account for 98% of the total fat of whole body, owing to being identified, therefore also known as " visible fat ".The caloric value of energy fat is quite large, with regard to same weight, its caloric value be sugar, starch, 2 times of protein.Its main Physiological Function is supply energy, can be employed when body requirement, plays protection body, maintains normal body temperature, cushion mechanical shocks, fix and protect each internal organs and organize joint, promote the effects such as the absorption of liposoluble vitamin.Structural fatty, also known as " invisible fat ", primarily of many carbon unrighted acid composition, to form the form of partes corporis humani's point eucaryotic cell structure composition, is extensively present in the cell of brain, liver, lung, the heart, spleen, testis and musculature.Up to the present, people there is no method and see it, thus also known as " invisible fat ".Structural fatty main Physiological Function forms body, provides many carbon unrighted acid, neuroprotective tissue.Such as, to form the fatty material of brain important materials, be structural fatty but not the energy is fatty.Wherein 40% ~ 50% is many carbon unrighted acid (as DHA).Many carbon unrighted acid is the needs building the good brain of structure quality, is the needs that the structure quality of brain is taken a turn for the better.Many carbon unrighted acid mainly refers to linoleic acid (octadecadienoic acid), leukotrienes (octatecatrienoic acid), arachidonic acid (eicosatetraenoic acid), eicosapentaenoic acid and 22 carbon six diluted acids.Wherein leukotrienes is divided into a-leukotrienes and gamma-Linolenic acid due to position of double bond difference.In numerous unsaturated acids, linoleic acid and a-leukotrienes, must by food supplies because not synthesized by candy, protein and other nutrients in vivo, and be otherwise known as " essential fatty acid ".The most basic source of essential fatty acid is plant, animal tallow or synthesis.
Daily edible vegetable oil, no matter any, all contain visible fat acid (energy aliphatic acid) i.e. saturated fatty acid, play the effect that human body energy is provided.What people paid close attention to most is structural fatty acid and unrighted acid, and namely two kinds of essential fatty acids (linoleic acid and a-leukotrienes), are the health and the life-span that decide the mankind on a molecular scale, significant.
Essential fatty acid has its feature, one, and metabolic enzyme is identical, but metabolite is different, collaborative performance biological effect between metabolite.They are two years old, in chemical constitution, double bond number is different, position of double bond is also different, in order to distinguish and identify, people by terminal double bond on third from the bottom carbon be called ω-3 series, 6th carbon reciprocal is called ω-6 series, and linoleic acid and metabolite gamma-Linolenic acid thereof and arachidonic acid belong to ω-6 series, and a-leukotrienes and metabolite eicosapentaenoic acid thereof and 22 carbon six diluted acids belong to ω-3 series.
Various aliphatic acid is all beneficial to human body, but the absorption ratio of essential fatty acid and intake will guide the direction of human adipose's absorption.Linoleic acid and alpha-linolenic acid only have and enter body by a certain percentage at the same time, and metabolite could display biological yields group effect, otherwise will mutually restrict, and causes harmful effect to body.
At present, the edible vegetable oil produced in China is not the main linoleic acid containing ω-3 series is exactly the main alpha-linolenic acid containing ω-3 series, so it is necessary for carrying out being in harmonious proportion.But be in harmonious proportion and must have science, if be grouped into polyunsaturated fatty acid category unified for two kinds of essential fatty acids, there is no proportionate relationship, then do not meet the synchronous metabolic demand of body.In fact, take much count of the absorption problem of ω-3 type essential fatty acid both at home and abroad, Japan is law-making stipulation for a long time, must add ω-3 type many carbon unrighted acid, otherwise will not sell in multiclass food; Germany etc. country patent using alpha-linolenic acid as medicine and food additives; The World Health Organization and FAO (Food and Agriculture Organization of the United Nation), issue a statement to the world with regard to serious for 1993, and in view of the importance of ω-3 type many carbon unrighted acid and the situation of the general insufficiency of intake of the mankind, suggestion is wanted special and supplemented ω-3 type many carbon unrighted acid; China scientific research personnel, through the investigation of a large amount of nutrition, mensuration, has determined the half (WHO advise everyone edible at least 2 gram/day) of the amount of equal daily ingestion alpha-linolenic acid in population of China no more than world health organisation recommendations amount 1 gram.But all do not relate to the proportion compatibility of two kinds of essential fatty acids in certain specific edible product, do not emphasize that the two enters the importance of body simultaneously yet.
Linoleic acid and alpha-linolenic acid are the parent of ω-6 and ω-3 more than carbon unrighted acid (arachidonic acid AA, eicosapentaenoic acid EPA, 22 carbon six diluted acid DHA) in body respectively, both and carbochain thereof extend product and can not mutually transform, the effect of ω-3 and ω-6 aliphatic acid can not phase trans-substitution, only has compatibility could the real value embodying essential fatty acid.
Summary of the invention
The object of the present invention is to provide a kind of edible oil containing two kinds of essential fatty acids, or be called containing ω-6 and ω-3 edible oil, to meet the demand of human body to essential fatty acid.
For achieving the above object, the edible oil containing two kinds of essential fatty acids provided by the invention, for a-leukotrienes or its metabolite in 1: 1-10 the mixture that forms with linoleic acid or its metabolite of ratio.
Aforementioned proportion of the present invention has different proportion requirement according to actual needs, as popular ω-3 edible oil, a-leukotrienes: linoleic acid=1: 5-10, calculating according to taking in 25 grams of edible oils for each person every day, human body should be met and take in the linoleic acid of more than 10 grams and the a-leukotrienes standard of more than 2 grams every day.
Described edible oil, wherein, the linolenic metabolite of a-is eicosapentaenoic acid and DHA.
Described edible oil, wherein, linoleic metabolite is gamma-Linolenic acid and arachidonic acid.
Described edible oil, wherein, one or more in interpolation vitamin E, fat-soluble tea polyphenol, butylated hydroxy anisole (BHA), 2,6 BHTs (BHT) are as protective agent.
Described edible oil, wherein, one or more in interpolation vitamin C, Organic Selenium, organic germanium, lecithin are as protective agent.
Edible oil of the present invention can be applicable to the medicine preparation treating and prevent high fat of blood, hypertension and hyperglycaemia, can also be applied in the preparation of nutraceutical.
For ease of carrying and taking, edible oil of the present invention can be made into liquid-type, oral liquid formulation and capsule formulation.
Carbon more than two kinds of the present invention does not wrap with in aliphatic acid, linoleic acid (linoleic acid) formal name used at school 9,12-octadecadienoic acid, is all-cis formula octadecadienoic acid.Alpha-linolenic acid (α-linolenic acid is called for short leukotrienes) formal name used at school cis 9,12,15-oc-tadecatrienoic acid is all-cis formula octatecatrienoic acid.From:
1) plant, as safflower seed oil, flax (also referred to as flax) seed oil, perilla oil, walnut oil, sunflower oil, peanut oil, soybean oil, rape seed oil, sesame wet goods;
2) from animal if marine animal fish etc., terraria are as horse dog chicken and duck etc.;
3) from synthesis: as linoleate, linolenate etc.
Detailed description of the invention
The chemical constitution of two kinds of essential fatty acids (many carbon does not wrap and aliphatic acid) that the present invention adopts except double bond number different with position, other difference is less, due to the accurate identification of carburetting enzyme, the difference of metabolite both just having had, but have Close relation.
As medicine or functional food ingredients, ω-3 and ω-6 aliphatic acid all have the danger etc. of angiocardiopathy preventing, treatment hyperlipemia, slight senile dementia, reduction cholesterolemia, but, if the two ratio not to or single use excessive, all can cause the safety issue of many carbon unrighted acid.
There is autoxidation in atmosphere very soon because its active character makes it expose and go bad in many carbon unrighted acid (essential fatty acid) goods, even produces noxious material, thus lose its business and nutritive value.Although also do not propose omega-fatty acid safety issue specially, some are had to cause the report of rodent changes of liver function about the heavy dose of omega-fatty acid of absorption.Low-density lipoprotein (LDL) according to being rich in omega-fatty acid raises the sensitiveness of oxidation in vitro; antioxidant can be increased as safeguard measure; when utilizing many carbon unrighted acid to prepare functional food; vitamin E, fat-soluble tea polyphenol, butylated hydroxy anisole (BHA), 2; 6 BHTs (BHT), vitamin C, Organic Selenium, organic germanium and lecithin are all conventional antioxidant or anti-oxidant auxiliary agent; be again good physiological activator simultaneously, with essential fatty acid, there is cooperative effect.
Embodiment 1:
Mediation sunflower oil ratio (%)
Sunflower oil (containing linoleic acid more than 60%) 50
Siritch (containing a-leukotrienes more than 50%) 50
Embodiment 2:
ω-3 edible oil (mediation peanut oil) ratio (%)
Peanut oil (linoleic acid about 40%) 50
Siritch (containing a-leukotrienes more than 50%) 20
Safflower oil (linoleic acid more than 80%) 30
Embodiment 3:
ω-3 edible oil (mediation soybean oil) ratio (%)
Soybean oil (linoleic acid about 50%) 75
Siritch (containing a-leukotrienes more than 50%) 20
Safflower oil (linoleic acid more than 80%) 15
Embodiment 4:
ω-3 edible oil ratio (%)
Sunflower oil (containing linoleic acid more than 60%) 84
Siritch (containing a-leukotrienes more than 50%) 16
Embodiment 5: for the preparation of medicine
Linoleic acid is already as clinical blood lipid-lowering medicine, and have linoleic acid pill, linoleic acid compound ball (yishouning), linoleic acid compound ethyl ester ball (lipid level and Maitong), shortcoming is all the linoleic acid of single component.Quasi-drugs of the present invention all should compatibility a-leukotrienes, and such as selenizing safflower seed oil is exactly the safflower seed oil compound formulation with a-leukotrienes compatibility, raises the chief of safflower seed oil, keeps away the shortage of safflower seed oil.
Embodiment 6: be applied in nutraceutical
Essential fatty acid general not with other nutritional labeling generation chemical reaction and Ant agonism, as vitamins, amino acids, trace element etc.Therefore, all essential fatty acid can be added when formulation allows.As oral liquid formulation and capsule formulation.
Embodiment 7: be applied in condensed food
With body specific demand, be that the food of carrier is called condensed food with food, as strengthened the food, strengthening intelligence food, strengthening bone growth food etc. of children growth, when preparing these food, as long as formulation license all can add essential fatty acid.Selenizing safflower seed oil soft capsule is condensed food, in compatibility essential fatty acid, add micro-Organic Selenium, has both played the effect of compatibility essential fatty acid, has mended selenium again.
In order to verify effect of the present invention, the present invention obtains alpha-linolenic acid from siritch, be prepared into three assembly 5 safflower seed oils by different proportion, and carry out animal reducing blood lipid test by various dose, with deep sea fish oil (n-3 series many carbon unrighted acid) and linoleic acid product in contrast.Wherein:
Compatibility safflower seed oil A: safflower oil (containing linoleic acid 80%): alpha-linolenic acid linoleic acid mixed acid (containing alpha-linolenic acid 62%, linoleic acid 22%)=1: 4; Amount to linoleic acid: alpha-linolenic acid=1: 5;
Compatibility safflower seed oil B: safflower oil: alpha-linolenic acid linoleic acid mixed acid=2: 3; Amount to linoleic acid: alpha-linolenic acid=1.2: 1;
Compatibility safflower seed oil C: safflower oil: alpha-linolenic acid linoleic acid mixed acid=3: 2; Amount to linoleic acid: alpha-linolenic acid=2.5: 1.
According to rat mtd test determination animal experiment dosage, definition heavy dose is 150mg/100g; Middle dosage is 100mg/100g; Low dose is 50mg/100g.
Result shows, and linoleic acid and these two kinds of essential fatty acids of alpha-linolenic acid not only must use by compatibility, and dose-effect relationship is clear and definite, and wherein B prescription can reduce triglyceride levels, can reduce cholesterol levels again, is better than A and C formula.Result of the test is in table 1.
Table 1: compatibility safflower seed oil is on the impact of Serum Lipids in Experimental HypercholesterolemicRats
In table,
*p < 0.05 compared with high fat salt solution group,
*p < 0.01 compared with high fat salt solution group
Compared with hyperlipidemia model group, deep sea fish oil group only triglycerides (TG) reduces, and difference has statistical significance (p < 0.05); In compatibility essential fatty acid A, B, C tri-prescriptions, little, in, large three dosage groups all reduce TG, difference has statistical significance (p < 0.01), and effect is better than deep sea fish oil group.Heavy dose in B prescription can reduce cholesterol (CHOL), low-density lipoprotein (LDLC), and difference has statistical significance (p < 0.01).
Inventor's soft capsule of having selected optimization formula to prepare, and use among the people (selecting vegetable oil raw materials, without any ill-effect), wherein to 20 hypertriglyceridemia person's tracing observations, result is efficient reaches 100%.By with document comparative analysis, compatibility essential fatty acid lipid-lowering effect is better than safflower oil (containing linoleic acid more than 80%) about 15 times, describes the importance of compatibility.
Claims (1)
1. the application of the edible oil containing two kinds of essential fatty acids in preparation treatment and prevention high fat of blood medicine, is characterized in that this edible oil is: a-leukotrienes is by weight 1: 1-10 and linoleic mixture; Add vitamin E, fat-soluble tea polyphenol, butylated hydroxy anisole, 2, one or more in 6 BHTs, vitamin C, Organic Selenium, organic germanium, lecithin are as protective agent.
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101919457A (en) * | 2010-09-01 | 2010-12-22 | 吴桂荣 | Blended linseed oil and applications |
| CN102696787A (en) * | 2012-06-05 | 2012-10-03 | 通化长白山药谷集团有限公司 | Edible oil containing two essential fatty acids |
| CN103766909A (en) * | 2012-10-17 | 2014-05-07 | 曾晓飞 | Novel food rich in omega-3 compounded food supplement |
| CN106267212A (en) * | 2015-05-15 | 2017-01-04 | 何灌生 | A kind of lecithin health product |
| CN104983916B (en) * | 2015-07-23 | 2016-08-24 | 深圳市荣格保健品有限公司 | There are health product of enhancing immunity and slow down aging and preparation method and application |
| CN106360732A (en) * | 2016-08-31 | 2017-02-01 | 刘颖 | Linoleic and linolenic acid, preparation method thereof and linoleic and linolenic acid preparation |
| CN108117926A (en) * | 2018-02-27 | 2018-06-05 | 江苏金洲粮油食品有限公司 | A kind of fit-keeping flax seed oil extractant |
| CN108384635A (en) * | 2018-02-27 | 2018-08-10 | 江苏金洲粮油食品有限公司 | A kind of efficient linseed oil extractant |
| CN112655775A (en) * | 2020-12-03 | 2021-04-16 | 刘袭文 | Selenium-rich high linoleic acid safflower seed oil |
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| WO2007121273A2 (en) * | 2006-04-11 | 2007-10-25 | Martek Biosciences Corporation | Food products comprising long chain polyunsaturated fatty acids and methods for preparing the same |
| CN101088349A (en) * | 2006-06-13 | 2007-12-19 | 南海油脂工业(赤湾)有限公司 | Edible blend oil containing docosahexenoic acid |
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| CN101098629B (en) * | 2004-11-04 | 2010-10-13 | 孟山都技术公司 | High PUFA oil compositions |
| CN1943372A (en) * | 2006-11-02 | 2007-04-11 | 保靖县武陵山花椒科技开发有限公司 | Linolenic acid health edible oil and prickly ash seed dregs and its preparing method |
| CN101091504A (en) * | 2007-06-12 | 2007-12-26 | 上海地源食品有限公司 | Green tea oil, and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2007121273A2 (en) * | 2006-04-11 | 2007-10-25 | Martek Biosciences Corporation | Food products comprising long chain polyunsaturated fatty acids and methods for preparing the same |
| CN101088349A (en) * | 2006-06-13 | 2007-12-19 | 南海油脂工业(赤湾)有限公司 | Edible blend oil containing docosahexenoic acid |
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