CN101530317B - Lacrimal river detection device and data treatment device - Google Patents
Lacrimal river detection device and data treatment device Download PDFInfo
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Abstract
The invention discloses a lacrimal river detection method and device thereof, a data treatment device, wherein the lacrimal river detection device comprises a coherent light fault scanner for detecting lacrimal river to obtain the lacrimal river section profile of preset mode; a data treatment device connected with the coherent light fault scanner, using the preset lacrimal river section profile feature result to match with the obtained lacrimal river section profile and the matching result is obtained to identify the dividing line between the lacrimal film outer surface and the air and the intersection point of the cornea and lower eyelid and the dividing line and the length between the dividing line and the connection point of the cornea and the lower eyelid is the lacrimal river heightand the distance between the intersection point of the cornea and the lower eyelid and the midpoint of the dividing line is the lacrimal river depth, the lacrimal river height and depth are respectively identified whether in the normal lacrimal river depth and the height reference range or not and the identification result is output. The lacrimal river detection method and device thereof is a validated standardization detection method, device, which can accurately and conveniently obtain the lacrimal river detection result.
Description
Technical field
The present invention relates to medical domain, particularly relate to the lacrimal river checkout equipment.
Background technology
Lacrimal river is a tear band that accumulates between anterior ocular segment lower eyelid and angle conjunctiva, often need detect lacrimal river on clinical ophthalmology, whether has condition of illness such as xerophthalmia with affirmation.Traditional lacrimal river detection method is to utilize equipment such as slit lamp to check, but this method often has invasive and repeatable bad, the accuracy that influence is checked.
Characteristics such as OCT (OCT) is a kind of equipment that a kind of common being used to scans optical fundus and anterior ocular segment tissue, has Noninvasive, and imaging is accurate.Therefore, in 2006, external one piece of magazine (Savini G, Barboni P, Zanini M.Tear meniscusevaluation by optical coherence tomography.Ophthalmic SurgLasers Imaging.2006,37:112-118.) report utilizes through the OCT of ordering parameter equipment (as the Stratus OCT3 of Ka Er Zeiss), can be used for preocular lacrimal river place and scan, thereby draw the faultage image of lacrimal river.The faultage image that utilization measures can obtain the lacrimal river height and the degree of depth, and then helps researching and analysing of xerophthalmia.
The above-mentioned OCT of utilization carries out in the technology of lacrimal river detection, after the lacrimal river image that OCT scanned need being derived, call in outside large-scale image software (PHOTOSHOP) again, after handling through image convergent-divergent, rotation etc., measures again.Because need the processing operations such as convergent-divergent through image, method is more loaded down with trivial details, might produce certain influence to the precision of measuring; Simultaneously, the technology that above-mentioned existing employing OCT carries out the lacrimal river detection is not made assessment to the reliability and the accuracy of this method, does not do standardization yet, and is not suitable for clinical; In addition, the parameter that above-mentioned prior art is measured only comprises height value and depth value, and is unfavorable for further utilization in clinical and scientific research practical operation.
Summary of the invention
Utilize the method for OCT detection lacrimal river to be difficult to obtain technological deficiency accurate, reliable detection result for solving prior art, the invention provides a kind of Noninvasive, utilize existing OCT equipment to carry out lacrimal river reliably, accurately to detect its equipment, data processing equipment, can be conveniently clinical, scientific research uses.
One aspect of the present invention provides a kind of lacrimal river checkout equipment, comprising: the coherent light tomoscanner that is used for lacrimal river is detected and obtains the lacrimal river profiled outline; Data processing equipment comprises: matching unit, connect described coherent light tomoscanner, and be used to adopt default lacrimal river profiled outline characteristic information to mate the lacrimal river profiled outline that described detection obtains, and obtain matching result; Recognition unit is used to analyze the matching result of described matching unit output, and identifies tear film outer surface and air demarcation line, cornea and the lower eyelid intersection point of the lacrimal river in the lacrimal river profiled outline that described detection obtains; Computing unit, be used for height, the degree of depth according to the described lacrimal river of described recognition unit computes, comprise: get described demarcation line respectively and the length between the junction point of cornea, lower eyelid be the lacrimal river height, tear film outer surface that obtains in described detection and air demarcation line only some the time, prolong the cornea at described demarcation line to its two ends and lower eyelid, resulting whole marginal length is the lacrimal river height, get cornea and lower eyelid intersection point, and described demarcation line mid point between the distance of line be the lacrimal river degree of depth; Comparing unit is used for contrasting respectively lacrimal river height, the degree of depth that described computing unit obtains and whether falls into normal lacrimal river height, degree of depth term of reference, and the output comparing result.
Wherein, described data processing equipment further comprises first scaling unit, be used for according to the proportionate relationship formula of the sweep length value of setting with the sweep length that is actually used in anterior ocular segment scanning, the described lacrimal river height that described computing unit is obtained, depth value be the sweep length value position of the setting in the described proportionate relationship formula of substitution respectively, obtain actual lacrimal river height, depth value, and import described comparing unit.
Wherein, described data processing equipment further comprises second scaling unit, is used for when described normal lacrimal river height, degree of depth term of reference are the measured value that obtains of slit lamp, utilizes convert contrast both sides' numerical value of following formula:
The lacrimal river height of obtaining, the degree of depth=[1.029 * (slit lamp height, depth measurement)]-0.172mm, and import described comparing unit.
Another aspect of the present invention is that a kind of data processing equipment that lacrimal river detects that is applied to also is provided, be embedded in the coherent light tomoscanner, it is characterized in that, comprise: matching unit, import described coherent light tomoscanner and detect the lacrimal river profiled outline that obtains under the preset mode, be used to adopt default lacrimal river profiled outline characteristic information to mate the lacrimal river profiled outline that described detection obtains, and obtain matching result; Recognition unit is used to analyze the matching result of described matching unit output, and identifies tear film outer surface and air demarcation line, cornea and the lower eyelid intersection point of the lacrimal river in the lacrimal river profiled outline that described detection obtains; Computing unit, be used for height, the degree of depth according to the described lacrimal river of described recognition unit computes, comprise: get described demarcation line respectively and the length between the junction point of cornea, lower eyelid be the lacrimal river height, tear film outer surface that obtains in described detection and air demarcation line only some the time, prolong the cornea at described demarcation line to its two ends and lower eyelid, resulting whole marginal length is the lacrimal river height, get cornea and lower eyelid intersection point, and described demarcation line mid point between the distance of line be the lacrimal river degree of depth; Comparing unit is used for contrasting respectively lacrimal river height, the degree of depth that described computing unit obtains and whether falls into normal lacrimal river height, degree of depth term of reference, and the output comparing result.
The invention has the beneficial effects as follows: be different from prior art and utilize the method for OCT detection lacrimal river to be difficult to obtain accurately, reliable detection result's technological deficiency, the invention provides a kind of Noninvasive, reliably, utilize existing OCT equipment to carry out the lacrimal river checkout equipment accurately, data processing equipment, can mate OCT by default lacrimal river profiled outline characteristic information and detect the lacrimal river profiled outline that obtains, thereby obtain the tear film outer surface and the air demarcation line of the lacrimal river in the lacrimal river profiled outline automatically, cornea and lower eyelid intersection point, after obtaining these information, can accurately obtain the lacrimal river height, data such as the degree of depth, draw comparing result by comparison and detection result and normal data at last, avoid process image convergent-divergent or manually-operated and cause testing result inaccurate, problem such as unreliable, the inventive method is also by lot of experiment validation and analysis, the proof reliability, accuracy is higher, can carry out clinical, scientific research is used.
Description of drawings
Fig. 1 is the flow chart of lacrimal river detection method of the present invention;
Fig. 2 is the sketch map that carries out the lacrimal river volume estimation among the present invention according to the lacrimal river sectional area;
Fig. 3 is the theory diagram of lacrimal river checkout equipment first embodiment of the present invention;
Fig. 4 is the theory diagram of lacrimal river checkout equipment second embodiment of the present invention;
Fig. 5 is the theory diagram of lacrimal river checkout equipment the 3rd embodiment of the present invention;
The theory diagram of Fig. 6 data processing equipment of the present invention;
Fig. 7 detects the sketch map that the lacrimal river profiled outline that obtains is determined the lacrimal river height according to the present invention;
Fig. 8 detects the sketch map that the lacrimal river profiled outline that obtains is determined the lacrimal river degree of depth according to the present invention.
The specific embodiment
The present invention is further described below in conjunction with drawings and embodiments.
Please refer to Fig. 1, is the flow chart of lacrimal river detection method of the present invention.Described method comprises step:
101: adopt the coherent light tomoscanner that lacrimal river is detected, obtain the lacrimal river profiled outline of preset mode; Described preset mode is meant the eyes pattern in special angle, specific direction, particular state, such as the cross section of eyes part vertical direction, and the state that eyes are opened.
102: adopt default lacrimal river profiled outline characteristic information to mate the lacrimal river profiled outline that described detection obtains, identify tear film outer surface and air demarcation line, cornea and the lower eyelid intersection point of the lacrimal river in the lacrimal river profiled outline that described detection obtains; Described default lacrimal river profiled outline characteristic information can be that these features should be unique, diacritic through information such as the shape that has feature in the standard lacrimal river profiled outline that experiment draws in a large number, lines, darknesses.
103: get described demarcation line respectively and the length between the junction point of cornea, lower eyelid be the lacrimal river height, tear film outer surface that obtains in described detection and air demarcation line only some the time, prolong the cornea at described demarcation line to its two ends and lower eyelid, resulting whole marginal length is the lacrimal river height, get cornea and lower eyelid intersection point, and described demarcation line mid point between the distance of line be the lacrimal river degree of depth;
104: contrast the described lacrimal river height of obtaining respectively, whether the degree of depth falls into normal lacrimal river height, degree of depth term of reference, and the output comparing result.
More than, the invention provides a kind of Noninvasive, reliably, utilize existing OCT equipment to carry out method and the equipment thereof that lacrimal river detects accurately, data processing equipment, do not need to adopt eye is carried out the invasive processing, OCT detects the lacrimal river profiled outline that obtains but can be mated by default lacrimal river profiled outline characteristic information, thereby obtain the tear film outer surface and the air demarcation line of the lacrimal river in the lacrimal river profiled outline automatically, cornea and lower eyelid intersection point, after obtaining these information, can accurately obtain the lacrimal river height, data such as the degree of depth, draw comparing result by comparison and detection result and normal data at last, the data that directly Equipment Inspection obtains to OCT are carried out direct analysis, the error of avoiding data conversion process to cause, also avoid process image convergent-divergent or manually-operated and cause testing result inaccurate, problem such as unreliable, the inventive method is also by lot of experiment validation and analysis, the proof reliability, accuracy is higher, can carry out clinical, scientific research is used.
In other embodiments, can after measuring lacrimal river height, the degree of depth, further comprise step:
Adopt the method on fitted figure border to obtain directly obtaining the sectional area of described lacrimal river the lacrimal river profiled outline image, and contrast sectional area and normal lacrimal river sectional area that described detection obtains, output comparing result from described detection.This step is on the basis of contrast lacrimal river height, depth step, further further confirms comparing result according to the lacrimal river sectional area, further improves the accuracy of comparing result; Perhaps
Consult Fig. 2, the method that adopts the fitted figure border obtains directly obtaining the lacrimal river profiled outline image sectional area of described lacrimal river from described detection, in the empirical equation that the substitution of described lacrimal river sectional area is predetermined, draw the lacrimal river volume of estimation, and contrast the lacrimal river volume and normal lacrimal river volume that described estimation obtains, export comparing result.Among Fig. 2, demonstration be the schematic three dimensional views of lacrimal river volume estimation, dotted line target class triangle is the lacrimal river cross-sectional image that OCT adopts, and utilizes this image and corresponding prediction equation, the lacrimal river bulking value that can obtain estimating.
More than, comprehensively lacrimal river height, the degree of depth, sectional area, each parameter of volume significantly improve precision and accuracy that lacrimal river detects, make to utilize the present invention to carry out the technique effect that lacrimal river detects the erroneous judgement of realization nothing basically.
And, after obtaining described lacrimal river height, depth value, can further include step:
According to the proportionate relationship formula of the sweep length value of setting with the sweep length that is actually used in anterior ocular segment scanning, sweep length value position with the setting in the described described lacrimal river height of obtaining, the described proportionate relationship formula of depth value difference substitution obtains actual lacrimal river height, depth value.This step is special characteristic at OCT equipment, and there are the certain proportion relation in the data and the real data that obtain according to the OCT device measuring, thereby revise detection according to this proportionate relationship.
For the situation of the value that adopts slit lamp to measure in the method as normal lacrimal river height, degree of depth term of reference, can contrast the step whether described lacrimal river height of obtaining, the degree of depth fall into normal lacrimal river height, degree of depth term of reference respectively, utilize convert contrast both sides' numerical value of following formula:
The lacrimal river height of obtaining, the degree of depth=[1.029 * (slit lamp height, depth measurement)]-0.172mm.
Consult Fig. 3, the present invention also provides a kind of lacrimal river checkout equipment, comprising:
Be used for lacrimal river is detected and obtains the coherent light tomoscanner of lacrimal river profiled outline;
Data processing equipment comprises:
Matching unit connects described coherent light tomoscanner, is used to adopt default lacrimal river profiled outline characteristic information to mate the lacrimal river profiled outline that described detection obtains, and obtains matching result;
Recognition unit is used to analyze the matching result of described matching unit output, and identifies tear film outer surface and air demarcation line, cornea and the lower eyelid intersection point of the lacrimal river in the lacrimal river profiled outline that described detection obtains;
Computing unit, be used for height, the degree of depth according to the described lacrimal river of described recognition unit computes, comprise: get described demarcation line respectively and the length between the junction point of cornea, lower eyelid be the lacrimal river height, tear film outer surface that obtains in described detection and air demarcation line only some the time, prolong the cornea at described demarcation line to its two ends and lower eyelid, resulting whole marginal length is the lacrimal river height, get cornea and lower eyelid intersection point, and described demarcation line mid point between the distance of line be the lacrimal river degree of depth;
Comparing unit is used for contrasting respectively lacrimal river height, the degree of depth that described computing unit obtains and whether falls into normal lacrimal river height, degree of depth term of reference, and the output comparing result.
Above-mentioned lacrimal river checkout equipment is that the data that directly Equipment Inspection obtains to OCT are carried out direct analysis, avoid error that data conversion process causes, also avoid causing problems such as testing result is inaccurate, unreliable through image convergent-divergent or manually-operated, the inventive method is also by lot of experiment validation and analysis, proof reliability, accuracy is higher, can carry out clinical, scientific research and use.
And, adopt recognition unit, computing unit, comparing unit can reach automatization, the intelligent effect that detects, avoid eye-observation and the error that may occur, simplify testing process, shorten detection time.
Described recognition unit can connect a data base, described data base can comprise various lacrimal river types of profiles data, utilize described data base to identify tear film outer surface and air demarcation line, cornea and the lower eyelid intersection point of the lacrimal river in the lacrimal river profiled outline that described detection obtains, to improve recognition accuracy and success rate.
Consult Fig. 4, characteristic at OCT equipment, there are the certain proportion relation in the data and the real data that obtain according to the OCT device measuring, thereby can revise detection according to this proportionate relationship, therefore described data processing equipment may further include first scaling unit, be used for according to the proportionate relationship formula of the sweep length value of setting with the sweep length that is actually used in anterior ocular segment scanning, the described lacrimal river height that described computing unit is obtained, the sweep length value position of the setting in the described proportionate relationship formula of depth value difference substitution, obtain actual lacrimal river height, depth value, and import described comparing unit.
Consult Fig. 5, for tackling the normal lacrimal river height of value conduct that adopts slit lamp to measure, the situation of degree of depth term of reference, described data processing equipment may further include second scaling unit, be used for when described normal lacrimal river height, degree of depth term of reference are the measured value that obtains of slit lamp, utilize convert contrast both sides' numerical value of following formula:
The lacrimal river height of obtaining, the degree of depth=[1.029 * (slit lamp height, depth measurement)]-0.172mm,
And import described comparing unit.
In addition, consult Fig. 6, the present invention also provides a kind of data processing equipment that lacrimal river detects that is applied to, and is embedded in the coherent light tomoscanner, comprising:
Matching unit is imported described coherent light tomoscanner and is detected the lacrimal river profiled outline that obtains under the preset mode, is used to adopt default lacrimal river profiled outline characteristic information to mate the lacrimal river profiled outline that described detection obtains, and obtains matching result;
Recognition unit is used to analyze the matching result of described matching unit output, and identifies tear film outer surface and air demarcation line, cornea and the lower eyelid intersection point of the lacrimal river in the lacrimal river profiled outline that described detection obtains;
Computing unit, be used for height, the degree of depth according to the described lacrimal river of described recognition unit computes, comprise: get described demarcation line respectively and the length between the junction point of cornea, lower eyelid be the lacrimal river height, tear film outer surface that obtains in described detection and air demarcation line only some the time, prolong the cornea at described demarcation line to its two ends and lower eyelid, resulting whole marginal length is the lacrimal river height, get cornea and lower eyelid intersection point, and described demarcation line mid point between the distance of line be the lacrimal river degree of depth;
Comparing unit is used for contrasting respectively lacrimal river height, the degree of depth that described computing unit obtains and whether falls into normal lacrimal river height, degree of depth term of reference, and the output comparing result.
Describing in detail more below adopts the inventive method to realize the details that lacrimal river detects:
The first step adopts the CT examination method to obtain lacrimal river
(1) scan method: use OCT3 (Stratus OCT, 4.0.0.1 version software, Germany, Carl Zeiss Inc.) to check.OCT measurement lacrimal river is arranged in first and can checks, to reduce the influence of other test items to lacrimal river.The checking process of OCT be arranged in 1 temperature control, control wet (temperature is 26 ℃ ± 3 ℃, and humidity is in 53% ± 5RH%) room.Before test, close air-conditioning and door and window earlier, advise the patient to look squarely, and blink naturally to dead ahead; Afterwards OCT is focused on the eye table, use the long vertical scanning of 4mm, be centered close to the lacrimal river liquid bottom surface of cornea 6 o ' clock positions, promptly can scan lacrimal river profiled outline (Fig. 6) from lower eyelid to the angle conjunctival surface.
(2) measuring method:, therefore need to use data processing equipment provided by the invention to measure because OCT does not have and carries suitable survey tool.Wherein, the height of lacrimal river is just got the length A C (Fig. 6) between a upper and lower extremely corresponding A, the C of lacrimal river; If the lacrimal river profile has only the latter half to show, survey the height of lacrimal river and just get its lacrimal river lower edge to the distance (Fig. 7) between its extended line and the angle conjunctival surface intersection point.The degree of depth of lacrimal river get cornea and lower eyelid intersection points B to line between the tear film outer surface mid point D apart from BD (Fig. 8), utilize lacrimal river measurement pattern and sectional area pattern in the data processing equipment of the present invention to carry out the measurement of lacrimal river height, the degree of depth and sectional area during actual measurement.
(3) can prove the repeatability of OCT lacrimal river image measurement below: from the OCT information bank, utilize the OCT image document of table of random number method picked at random 52 width of cloth lacrimal rivers to carry out the measurement of lacrimal river height.1. the concordance between the gauger: by 3 gaugers 52 width of cloth images of choosing are measured respectively.The time that gauger's first is engaged in the OCT testing is half a year, and gauger's second, third is at first unified measurement standard through interim training 30min before the measurement.3 people's measurement is carried out at different time respectively, does not disturb mutually.2. the concordance in the gauger: in a few days 52 width of cloth images of choosing are measured repeated measure 3 times by gauger's first in difference.
(4) OCT measures the repeatability of lacrimal river: select 14 (28 eyes) volunteers (8 of male, 6 of women, 35 years old mean age) not scan respectively at not carrying out the OCT lacrimal river by gauger's first on the same day, and measure the lacrimal river height; Twice review time is at interval greater than 2 weeks.
Statistical analysis method of the present invention is through SPSS 13.0 software processes, and two groups of person under inspections' lacrimal river height, degree of depth result relatively use completely random t check, and the lacrimal river height is relevant with the correlation analysis employing Pearson of the degree of depth; The correlation analysis of OCT result and symptom, fluorescent staining, BUT, Schirmer result of the test adopts Spearman rank correlation; OCT lacrimal river relevant parameter is described with area under experimenter's performance curve (Receive Operating Characteristic curve, ROC curve) xerophthalmia diagnosis efficiency (diagnostic power); Interclass correlation coefficient analysis during the repeatability analysis employing reliability that OCT measures is analyzed (intraclass correlation coefficient, ICC).As difference statistical significance is arranged with P＜0.05.
For testing result, the meansigma methods of normal group lacrimal river height, the lacrimal river degree of depth, lacrimal river sectional area is respectively 0.25 ± 0.08mm, 0.23 ± 0.05mm, 0.0283 ± 0.0197mm2, and the meansigma methods of xerophthalmia group lacrimal river height, the lacrimal river degree of depth, lacrimal river sectional area is respectively 0.13 ± 0.05mm, 0.13 ± 0.06mm, 0.0103 ± 0.0062mm2.The lacrimal river height of matched group and xerophthalmia group, the degree of depth and sectional area value are through checking the laggard capable completely random t of number conversion, and difference all has statistical significance (lacrimal river height: t=-5.70, P＜0.001; The lacrimal river degree of depth: t=-5.17, P＜0.001; Lacrimal river sectional area: t=-4.33, P＜0.001).There is certain limit overlapping in the lacrimal river profile size of normal group and xerophthalmia group, and (lacrimal river high superposed scope is 0.12-0.24mm; The overlapping scope of the lacrimal river degree of depth is 0.10-0.31mm; The overlapping scope of lacrimal river sectional area is 0.0084-0.0320mm2).
Normal group symptom score meansigma methods is 0.54 ± 0.96, and the fluorescent staining meansigma methods is 0.91 ± 1.66, and the BUT meansigma methods is 11.53 ± 6.14 seconds, and Schirmer I meansigma methods is 20.85 ± 7.17mm; Xerophthalmia group symptom score meansigma methods is 1.81 ± 1.07, the fluorescent staining meansigma methods is 2.22 ± 2.42, the BUT meansigma methods is that 3.31 ± 2.35 seconds, Schirmer I meansigma methods are 6.10 ± 2.95mm.
Two groups the lacrimal river height and the degree of depth are carried out the Pearson correlation analysis, and the result is high-positive correlation (r=0.92, P＜0.001).Spearman correlation analysis with two groups of lacrimal river height values and depth value and symptom, fluorescent staining, BUT, Schirmer result of the test.Lacrimal river height, the degree of depth all are negative correlation (lacrimal river height r=-0.54, P＜0.001 with symptom; Lacrimal river degree of depth r=-0.56, P＜0.001); All uncorrelated (lacrimal river height: r=-0.22, P=0.07 with fluorescent staining; The lacrimal river degree of depth: r=-0.17, P=0.17); (lacrimal river height: r=0.47, P＜0.001 all are proportionate with BUT; The lacrimal river degree of depth: r=0.45, P＜0.001); Test be proportionate (lacrimal river height: r=0.61, P＜0.001 with Schi rmer; The lacrimal river degree of depth: r=0.59, P＜0.001).
OCT lacrimal river image relevant parameter represents with the ROC area under curve that to the xerophthalmia diagnosis efficiency wherein the ROC area under curve of lacrimal river height, the degree of depth and sectional area is respectively 0.921,0.884 and 0.895.When setting was xerophthalmia positive index with lacrimal river height (OCT3 lacrimal river original image)≤0.18mm, sensitivity was 89%, and specificity is 74%.
More than studying and can drawing OCT lacrimal river of the present invention measurement is to possess repeatability:
(1) concordance between the gauger: interclass correlation coefficient (ICC) is 0.993 (95%CI:0.990-0.996).
(2) concordance in the gauger: interclass correlation coefficient (ICC) is 0.994 (95%CI:0.990-0.996).
Wherein, twice not the interclass correlation coefficient ICC on the same day the gauger be 0.85 (95%CI0.69-0.92).
The contrast prior art, xerophthalmia inspection commonly used all has certain invasive.When carrying out Schirmer test, BUT inspection, conjunctival sac put into by reagent paper or the light direct irradiation is gone into ophthalmic, and discomfort has been told by patient regular meeting, simultaneously because the stimulation of test produces certain influence [9] [10] to the result.Inspections such as fluorescein sodium dyeing, video lacrimal river measuring instrument also usually need splash into a little fluorescein sodium toward conjunctival sac in, to the composition of tear with measure certain influence is arranged, cause the deviation [9] [10] [11] of check result.And OCT is when checking lacrimal river, and only very weak light enters ophthalmic, usually sweep time very short, do not add any reagent simultaneously toward ophthalmic, it is comfortable that the patient feels.
Identifying disease ability ROC area under curve commonly used is assessed.The ROC area under curve of OCT lacrimal river image relevant parameter is all higher, and wherein the ROC area under curve of lacrimal river height is 0.921; This experimental result (sensitivity 89%, specificity 74%) is compared [6] with traditional Schirmer I (sensitivity 75%, specificity 76%) and BUT test (sensitivity 84%, specificity 45%), has the diagnosis efficiency of higher diagnosis xerophthalmia.
The inventor discovers, same gauger does not carry out the slit lamp that with the naked eye carries out that repeatability (ICC=0.85) that the OCT lacrimal river measures is higher than Nichols research report on the same day and measures the repeatability [12] that lacrimal river height (ICC=0.29), Schirmer I test (ICC=0.44) and BUT test (ICC=0.65).In addition, this experiment has also been calculated between the gauger of existing OCT lacrimal river image and the repeatability in the gauger, and the result shows that the lacrimal river image of OCT3 has measurement reproducibility preferably.
In addition,, there is the people once to compare of the influence of multiple distinct methods such as OCT1, optics thickness measuring method, found that the measurement result of OCT1 is on the low side the lacrimal river height measurement results for the correction of testing result.Its reason may be relevant with the details that the pixelation and the pseudo color image of OCT generation can not react the lacrimal river afterbody, when carrying out the optics thickness measuring with the method that adds fluorescein sodium simultaneously, the Fluress amount of increase and the factor such as reflexive lacrimal secretion that promotes indirectly can bring also that the thickness measuring result's is higher.In the experiment of the lacrimal river model that the inventor did, also confirmed for same lacrimal river, the OCT measured value can be lower than the slit lamp measured value, and the measured value of two kinds of methods is height correlation (linear regression equation: OCT measured value=1.029 * slit lamp measured value-0.172mm, F=1243.8P＜0.001), utilize the lacrimal river height value after the conversion of regression equation estimation close with the slit lamp measurement result.
Compare with traditional slit lamp lacrimal river measuring method, the present invention adopts OCT to measure lacrimal river does not need to add fluorescein sodium, and having avoided the Fluress amount that increases and having reached reflexive stimulates the influence of lacrimal secretion to measurement result.It has measurement reproducibility preferably simultaneously, and the lacrimal river degree of depth can be provided, and the lacrimal river parameter that traditional methods such as sectional area can not provide also provides possibility for no invasive estimation lacrimal river volume.
In sum, the OCT that the present invention adopts checks that lacrimal river does not have invasive, can reflect that the lacrimal river faultage image carries out the measurement of lacrimal river parameter, can become a reference standard of clinical xerophthalmia diagnosis.
Measuring process of the present invention provides following two details:
1. when original OCT system is used for prosthomere scanning, have the proportional error of a length, promptly the sweep length value of She Dinging is also inconsistent with the sweep length that is actually used in anterior ocular segment scanning, need carry out the correction of ratio.Correction parameter can utilize methods such as scale ruler scanning to draw.For example, when the scanning of general setting 4mm length was used for anterior ocular segment because of focusing, the original image total length that draws was about the 5.5mm of actual object.According to practical situation, measured value is converted according to this ratio, promptly can draw actual object and measure length.
2. the inventor finds because OCT system and traditional slit lamp measuring method may exist different for the image-forming mechanism of lacrimal river, the lacrimal river measured value of OCT system can not be directly and the lacrimal river parameter measured of traditional method such as slit lamp directly compare, still need the conversion of carrying out.Therefore the performance model method has drawn an empirical equation and can be used for this conversion, i.e. " OCT measured value=1.029 * slit lamp measured value-0.172mm ".
Data processing equipment provided by the invention can be realized general accurate measurement function, and does not influence original analysis software.Think consistent with the original software measurement result of OCT with its measurement result of this software through paired t-test, its result's the coefficient of variation is less, and interclass correlation coefficient is bigger, has repeatable preferably.Conclusion: the software of universal image measurement, the measurement function of expansion can be provided for other image analysis system, have precision preferably, for the expanded application of original analytical equipment provides a kind of convenience practical tool.
More than to a kind of being described in detail provided by the present invention, used specific case herein principle of the present invention and embodiment set forth, the explanation of above embodiment just is used for help understanding method of the present invention and thought thereof; Simultaneously, for one of ordinary skill in the art, according to thought of the present invention, the part that all can change in specific embodiments and applications, in sum, this description should not be construed as limitation of the present invention.
Claims (4)
1. a lacrimal river checkout equipment is characterized in that, comprising:
Be used for lacrimal river is detected and obtains the coherent light tomoscanner of lacrimal river profiled outline;
Data processing equipment comprises:
Matching unit connects described coherent light tomoscanner, is used to adopt default lacrimal river profiled outline characteristic information to mate the lacrimal river profiled outline that described detection obtains, and obtains matching result;
Recognition unit is used to analyze the matching result of described matching unit output, and identifies tear film outer surface and air demarcation line, cornea and the lower eyelid intersection point of the lacrimal river in the lacrimal river profiled outline that described detection obtains;
Computing unit, be used for height, the degree of depth according to the described lacrimal river of described recognition unit computes, comprise: get described demarcation line respectively and the length between the junction point of cornea, lower eyelid be the lacrimal river height, tear film outer surface that obtains in described detection and air demarcation line only some the time, prolong the cornea at described demarcation line to its two ends and lower eyelid, resulting whole marginal length is the lacrimal river height, get cornea and lower eyelid intersection point, and described demarcation line mid point between the distance of line be the lacrimal river degree of depth;
Comparing unit is used for contrasting respectively lacrimal river height, the degree of depth that described computing unit obtains and whether falls into normal lacrimal river height, degree of depth term of reference, and the output comparing result.
2. lacrimal river checkout equipment according to claim 1 is characterized in that:
Described data processing equipment further comprises first scaling unit, be used for according to the proportionate relationship formula of the sweep length value of setting with the sweep length that is actually used in anterior ocular segment scanning, the described lacrimal river height that described computing unit is obtained, depth value be the sweep length value position of the setting in the described proportionate relationship formula of substitution respectively, obtain actual lacrimal river height, depth value, and import described comparing unit.
3. lacrimal river checkout equipment according to claim 1 is characterized in that:
Described data processing equipment further comprises second scaling unit, is used for when described normal lacrimal river height, degree of depth term of reference are the measured value that obtains of slit lamp, utilizes convert contrast both sides' numerical value of following formula:
The lacrimal river height of obtaining, the degree of depth=[1.029 * (slit lamp height, depth measurement)]-0.172mm, and import described comparing unit.
4. one kind is applied to the data processing equipment that lacrimal river detects, and is embedded in the coherent light tomoscanner, it is characterized in that, comprising:
Matching unit is imported described coherent light tomoscanner and is detected the lacrimal river profiled outline that obtains under the preset mode, is used to adopt default lacrimal river profiled outline characteristic information to mate the lacrimal river profiled outline that described detection obtains, and obtains matching result;
Recognition unit is used to analyze the matching result of described matching unit output, and identifies tear film outer surface and air demarcation line, cornea and the lower eyelid intersection point of the lacrimal river in the lacrimal river profiled outline that described detection obtains;
Computing unit, be used for height, the degree of depth according to the described lacrimal river of described recognition unit computes, comprise: get described demarcation line respectively and the length between the junction point of cornea, lower eyelid be the lacrimal river height, tear film outer surface that obtains in described detection and air demarcation line only some the time, prolong the cornea at described demarcation line to its two ends and lower eyelid, resulting whole marginal length is the lacrimal river height, get cornea and lower eyelid intersection point, and described demarcation line mid point between the distance of line be the lacrimal river degree of depth;
Comparing unit is used for contrasting respectively lacrimal river height, the degree of depth that described computing unit obtains and whether falls into normal lacrimal river height, degree of depth term of reference, and the output comparing result.
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